Beginning of HMDB00001
# Accession_No:
HMDB00001

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 12:02:26

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
1-Methylhistidine

# Description:
One-methylhistidine (1-MHis) is derived mainly from the anserine of dietary flesh sources, especially poultry. The enzyme, carnosinase, splits anserine into b-alanine and 1-MHis. High levels of 1-MHis tend to inhibit the enzyme carnosinase and increase anserine levels. Conversely, genetic variants with deficient carnosinase activity in plasma show increased 1-MHis excretions when they consume a high meat diet. Reduced serum carnosinase activity is also found in patients with Parkinson's disease and multiple sclerosis and patients following a cerebrovascular accident. Vitamin E deficiency can lead to 1-methylhistidinuria from increased oxidative effects in skeletal muscle.

# Synonyms:
1 methylhistidine; 1-methyl histidine; 1-MHis; 1-Methyl-Histidine; 1-Methyl-L-histidine; 1-N-Methyl-L-histidine; L-1-Methylhistidine; N1-Methyl-L-histidine; pi-methylhistidine

# Chemical_IUPAC_Name:
(2S)-2-amino-3-(1-methylimidazol-4-yl)propanoic acid

# Chemical_Formula:
C7H11N3O2

# Chemical_Structure:
tbl_chemical:::HMDB00001_ZOOM.png:::119283121747288589

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00001_THUMB.png:::119283121537336922

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alpha-aminoacid; aromatic compound; carboxylic acid; heterocyclic compound; primary aliphatic amine (alkylamine); primary amine

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
169.08511

# Molecular_Weight_Avg:
169.18114

# Smiles_String_isomeric:
CN1C=NC(C[C@H](N)C(O)=O)=C1

# Smiles_String_canonical:
CN1C=NC(CC(N)C(O)=O)=C1

# KEGG_Compound_ID:
C01152

# BioCyc_ID:
CPD-1823

# PubChem_CID:
92105

# PubChem_SID:
10225185; 14772557; 15171160; 206908; 4381; 668946; 8189415

# OMIM_ID:
212200

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
3741

# Ref_ID:
10362454; 7762816; 11052553; 2593832; 1819935; 2912013; 14156296; 7061274; 9478024; 15899597; 9029312; 1484110

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
332-80-9

# InChI:
InChI=1/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1

# Synthesis_Reference:
Greenstein, J.P. et al., Chemistry of the Amino Acids, Wiley, N.Y., 1961, 3, 2763; Barlos, K. et al., Annalen, 1989, 387; Jain, R. et al., Tetrahedron, 1996, 52, 5363-5370

# Melting_Point:
246-248 oC

# Melting_Point_predicted:
92.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
6.93 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.8 [Predicted by PubChem via XLOGP]; -2.94 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1166125930.mol:::164198335751476

# SDF_File_[Text]:
tbl_chemical:::HMDB00001.sdf:::119283121196395808

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00001.pdb:::119283121396864392

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_presat.png:::114617840545472471

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_presat.zip:::114617840545868826

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041031_P00_04_IS_1DP_Assigned.png:::115627307937961123

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Not Available

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674.png:::114789597381635980

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674.zip:::114789597383999424

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041031_P00_04_IS_2DHSQC_674_Assigned.png:::114989116860249523

# Predicted_H_NMR_Spectrum:
tbl_chemical:::1-Methyl-Histidine.gif:::1132732097468759823

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00001_peaks.txt:::1155589605667826750

# Predicted_C_NMR_Spectrum:
tbl_chemical:::1-Methyl-Histidine_C.gif:::1132737652730893393

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00001_peaks.txt:::1155590384782746583

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00001_L.png:::119127187766612754; Medium Energy:tbl_ms:::HMDB00001_M.png:::119127187683633793>>>; High Energy:tbl_ms:::HMDB00001_H.png:::119127187849628912>>>

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Muscle; Skeletal Muscle;

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Saliva; Urine

# Concentration_[Normal]:
Urine	4.6 +/- 2.7	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	2.3 +/- 5.1	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	46.1 +/- 53.5	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	15.9 +/- 19.5	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Urine	28.1 +/- 31.8	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	1.3 +/- 2.76	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	45.5 +/- 41.6	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	11052553
Urine	33.6 +/- 36.4	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	11052553
Blood	19.5 (0-39)	uM	Adult:>18_yrs_old	Both	Normal	7762816
Blood	19.44 +/- 14.93	uM	Adult:>18_yrs_old	Both	Normal	7061274 
Blood	9.1 +/- 7.2	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Blood	4.0 +/- 8.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 85-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	4.0 +/- 1.74	uM	Adult:>18_yrs_old	Both	Normal	17031479
Saliva	26.34	uM	Adult:>18_yrs_old	Both	Normal	1819935
Cellular_Cytoplasm	2 - 156	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15899597


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	2.6 +/- 1.13	uM	Adult:>18_yrs_old	Both	Alzheimer's Disease	17031479


# Associated_Disorders:
Alzheimer's Disease; Cachexia

# Pathway_Names:
Histidine Metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00340

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5713

# Metabolic_Enzyme_1_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_1_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_1_Gene_Name:
CNDP1

# Metabolic_Enzyme_1_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_1_Number_of_Residues:
507

# Metabolic_Enzyme_1_Molecular_Weight:
56693

# Metabolic_Enzyme_1_Theoretical_pI:
4.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_1_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_1_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CNDP1

# Metabolic_Enzyme_1_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_1_Locus:
18q22.3

# Metabolic_Enzyme_1_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_1_General_References:
12975309

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00001

Beginning of HMDB00002
# Accession_No:
HMDB00002

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-04-23 14:46:09

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
1,3-Diaminopropane

# Description:
A stable, flammable and highly hydroscopic fluid.  It is a polyamine that is normally quite toxic if swallowed, inhaled or absorbed through the skin.  It is a catabolic byproduct of spermidine.  It is also a precursor in the enzymatic synthesis of beta-alanine.  1, 3-Diaminopropane is involved in the arginine/proline metabolic pathways and the beta-alanine metabolic pathway

# Synonyms:
1,3-Diamino-n-propane; 1,3-Propylenediamine; 1,3-Trimethylenediamine; 1,3-propanediamine; 3-Aminopropylamine; Propane-1,3-diamine; TMEDA; Trimethylenediamine; a,w-Propanediamine

# Chemical_IUPAC_Name:
propane-1,3-diamine

# Chemical_Formula:
C3H10N2

# Chemical_Structure:
tbl_chemical:::HMDB00002_ZOOM.png:::119283122643436833

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00002_THUMB.png:::119283122460553014

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Alkyl Amines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine)

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
74.08440

# Molecular_Weight_Avg:
74.12490

# Smiles_String_isomeric:
NCCCN

# Smiles_String_canonical:
NCCCN

# KEGG_Compound_ID:
C00986

# BioCyc_ID:
CPD-313

# PubChem_CID:
428

# PubChem_SID:
11369168; 3132683; 73856; 11366606; 2377; 10318372; 3753359; 3754956; 11361872; 11493717; 589747; 3736672; 7646949; 11341689; 11375626; 8145139; 10324013; 3754109; 151124; 11487274; 559277; 10503763; 4233; 7853333; 8150629; 11364044; 11494964; 11377330

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
36543

# Wikipedia_ID:
TMEDA

# METLIN_ID:
5081

# Ref_ID:
3757213; 9226558; 5096953; 1150841; 6324613; 293750; 8624793; 3308180; 6713628; 9464484

# ChEBI_ID:
15725

# CAS_Registry_Number:
109-76-2

# InChI:
InChI=1/C3H10N2/c4-2-1-3-5/h1-5H2

# Synthesis_Reference:
Putochin, N., Ber., 1926, 59, 625; Ing, H.R. et al., J.C.S., 1926, 2348; Aspinall, S.R., J.A.C.S., 1941, 63, 2843; Whitmore, F.C. et al., J.A.C.S., 1944, 66, 725-728

# Melting_Point:
-12 oC

# Melting_Point_predicted:
21.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 437.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
2

# State:
Liquid

# LogP:
-1.43 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.40 [Predicted by ALOGPS]; -1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1,3-Diaminopropane.pdf:::1132562188382464025

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1,3-Diaminopropane.mol:::1132723680375540830

# SDF_File_[Text]:
tbl_chemical:::HMDB00002.sdf:::119283122141260173

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00002.pdb:::119283122287998934

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_noesy.png:::116890067225652158278

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_Presat.zip:::115514332651733031

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041107_P00_03_HW_1DP_Assigned.png:::115626695340649215

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744.png:::114789539537567341

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744.zip:::11478953954366596

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041107_P00_03_HW_2DHSQC_744_Assigned.png:::114989044946645182

# Predicted_H_NMR_Spectrum:
tbl_chemical:::1,3-Diaminopropane.gif:::1132732097734706016

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00002_peaks.txt:::1156309477880638625

# Predicted_C_NMR_Spectrum:
tbl_chemical:::1,3-Diaminopropane_C.gif:::113273765359215007

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00002_peaks.txt:::1156310670053882620

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00002L.png:::117555261802699271; Medium Energy:tbl_ms:::HMDB00002M.png:::117555266916363312; High Energy:tbl_ms:::HMDB00002H.png:::117555270802418922

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000001.png:::116890821476580881

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000001.txt:::116890821476521034

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000001.png:::116890821435959382

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000001.txt:::11689082147654173

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	2.55 (0.18-5.85)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9464484


# Concentration_[Abnormal]:
Urine	0.96 (0.12-2.11)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Cancer	9464484


# Associated_Disorders:
Cancer

# Pathway_Names:
Urea cycle and metabolism of amino groups

# Pathway_Images:
Urea_Cycle.jpg

# KEGG_Images:
map00220

# Pathway_Graphs:
Urea_Cycle_Graph.jpg

# Pathway_SBMLs:
Urea_Cycle.xml

# Metabolic_Enzyme_1_ID:
5451

# Metabolic_Enzyme_1_Name:
Deoxyhypusine synthase

# Metabolic_Enzyme_1_Synonyms:
DHS

# Metabolic_Enzyme_1_Gene_Name:
DHPS

# Metabolic_Enzyme_1_Protein_Sequence:
>Deoxyhypusine synthase
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
AFMHEKNED

# Metabolic_Enzyme_1_Number_of_Residues:
369

# Metabolic_Enzyme_1_Molecular_Weight:
40971

# Metabolic_Enzyme_1_Theoretical_pI:
5.02

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptidyl-amino acid modification
Process:  peptidyl-lysine modification
Process:  hypusine biosynthesis from peptidyl-lysine
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01916:DS

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.5.1.46

# Metabolic_Enzyme_1_GenBank_ID_Protein:
994715

# Metabolic_Enzyme_1_SwissProt_ID:
DHYS_HUMAN (P49366)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DHPS

# Metabolic_Enzyme_1_Geneatlas_id:
DHPS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2869

# Metabolic_Enzyme_1_PDB_ID:
1RQD

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1110 bp
ATGGAAGGTTCCCTGGAACGGGAGGCGCCAGCGGGGGCGCTGGCCGCCGTGCTAAAGCAC
AGCTCGACGTTGCCGCCCGAAAGCACCCAGGTCCGGGGCTACGACTTCAACCGCGGTGTG
AATTACCGCGCACTGCTGGAGGCCTTCGGCACCACCGGCTTCCAAGCAACCAACTTCGGG
CGCGCTGTACAGCAAGTCAATGCCATGATCGAGAAGAAGCTGGAACCACTGTCACAGGAT
GAAGACCAGCACGCGGACCTGACCCAGAGCCGCCGCCCACTTACCAGCTGCACCATTTTC
CTGGGATATACATCCAACCTCATCAGTTCAGGCATCCGTGAGACCATTCGCTACCTTGTG
CAGCACAACATGGTGGACGTATTGGTGACCACAGCTGGCGGCGTGGAGGAAGACCTCATC
AAGTGCCTGGCGCCCACATACTTGGGCGAGTTTAGCCTCAGGGGGAAGGAGCTCCGGGAG
AACGGGATCAATAGGATCGGAAACCTGCTGGTGCCCAATGAGAATTACTGCAAGTTTGAG
GACTGGCTGATGCCCATTCTGGACCAGATGGTGATGGAGCAGAACACAGAGGGTGTAAAG
TGGACGCCTTCTAAGATGATCGCCCGGCTGGGCAAGGAGATCAACAACCCAGAGTCCGTG
TATTACTGGGCCCAGAAGAACCACATCCCTGTGTTTAGTCCCGCACTTACAGACGGCTCG
CTGGGCGACATGATCTTCTTCCATTCCTACAAGAACCCGGGCCTGGTCCTGGACATCGTT
GAGGACCTGAGGCTCATCAACACACAGGCCATCTTTGCCAAGTGCACTGGGATGATCATT
CTGGGCGGGGGCGTGGTCAAGCACCACATTGCCAATGCCAACCTCATGCGGAACGGGGCC
GACTACGCTGTTTACATCAACACAGCCCAGGAGTTTGATGGCTCTGACTCAGGTGCCCGA
CCAGACGAGGCTGTCTCCTGGGGCAAGATCCGGGTGGATGCACAGCCCGTCAAGGTCTAT
GCTGACGCCTCCCTGGTCTTCCCCCTGCTTGTGGCTGAAACCTTTGCCCAGAAGATGGAT
GCCTTCATGCATGAGAAGAACGAGGACTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L39068

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_1_Locus:
19p13.2-p13.1

# Metabolic_Enzyme_1_SNPs:
rs10425108; rs34700558; rs35129924; rs10414020; rs11879732; rs8110996; rs8109945; rs8111830; rs11882854; rs34610671; rs1050609; rs9517; rs11541390; rs3177932; rs1050613; rs1050610; rs36111604; rs1050615; rs1050612; rs34635891; rs34824552; rs28472346; rs28758673; rs12461822; rs10420931; rs10426729; rs28666561; rs1002339; rs10410027; rs10414810; rs10417588; rs1053292; rs1053805; rs1054367; rs12609451; rs12976109; rs1376645; rs14343; rs3178210; rs3209404; rs34203441; rs34373915; rs35092999; rs7250744; rs7254207; rs7255750; rs7256839; rs7258212

# Metabolic_Enzyme_1_General_References:
7673224; 8549832; 8615810; 9666110; 9110174; 7750572; 9493264

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5631

# Metabolic_Enzyme_2_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_2_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_2_Gene_Name:
AOC2

# Metabolic_Enzyme_2_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_2_Number_of_Residues:
756

# Metabolic_Enzyme_2_Molecular_Weight:
83674

# Metabolic_Enzyme_2_Theoretical_pI:
7.03

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_2_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_2_Signals:
1-32

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_2_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AOC2

# Metabolic_Enzyme_2_Geneatlas_id:
AOC2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:549

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane

# Metabolic_Enzyme_2_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
9119395; 9722954

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5630

# Metabolic_Enzyme_3_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_3_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_3_Gene_Name:
AOC3

# Metabolic_Enzyme_3_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_3_Number_of_Residues:
763

# Metabolic_Enzyme_3_Molecular_Weight:
84623

# Metabolic_Enzyme_3_Theoretical_pI:
6.51

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_3_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_3_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_3_Signals:
1-19

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_3_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AOC3

# Metabolic_Enzyme_3_Geneatlas_id:
AOC3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:550

# Metabolic_Enzyme_3_PDB_ID:
1PU4

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
8972912; 9653080

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5627

# Metabolic_Enzyme_4_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_4_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_4_Gene_Name:
ABP1

# Metabolic_Enzyme_4_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_4_Number_of_Residues:
751

# Metabolic_Enzyme_4_Molecular_Weight:
85342

# Metabolic_Enzyme_4_Theoretical_pI:
7.01

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_4_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_4_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_4_Signals:
1-19

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_4_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_4_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ABP1

# Metabolic_Enzyme_4_Geneatlas_id:
ABP1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:80

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_4_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_4_Locus:
7q34-q36

# Metabolic_Enzyme_4_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_4_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
6322

# Metabolic_Enzyme_5_Name:
Ornithine decarboxylase

# Metabolic_Enzyme_5_Synonyms:
ODC

# Metabolic_Enzyme_5_Gene_Name:
ODC1

# Metabolic_Enzyme_5_Protein_Sequence:
>Ornithine decarboxylase
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL
LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF
QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

# Metabolic_Enzyme_5_Number_of_Residues:
461

# Metabolic_Enzyme_5_Molecular_Weight:
51149

# Metabolic_Enzyme_5_Theoretical_pI:
4.88

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  polyamine metabolism
Process:  polyamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-ornithine = putrescine + CO(2)

# Metabolic_Enzyme_5_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_5_Reaction:
L-ornithine = putrescine + CO2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02784:Orn_Arg_deC_N;
PF00278:Orn_DAP_Arg_deC

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 4.1.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
29893806

# Metabolic_Enzyme_5_SwissProt_ID:
DCOR_HUMAN (P11926)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ODC1

# Metabolic_Enzyme_5_Geneatlas_id:
ODC1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8109

# Metabolic_Enzyme_5_PDB_ID:
1D7K

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1386 bp
ATGAACAACTTTGGTAATGAAGAGTTTGACTGCCACTTCCTCGATGAAGGTTTTACTGCC
AAGGACATTCTGGACCAGAAAATTAATGAAGTTTCTTCTTCTGATGATAAGGATGCCTTC
TATGTGGCAGACCTGGGAGACATTCTAAAGAAACATCTGAGGTGGTTAAAAGCTCTCCCT
CGTGTCACCCCCTTTTATGCAGTCAAATGTAATGATAGCAAAGCCATCGTGAAGACCCTT
GCTGCTACCGGGACAGGATTTGACTGTGCTAGCAAGACTGAAATACAGTTGGTGCAGAGT
CTGGGGGTGCCTCCAGAGAGGATTATCTATGCAAATCCTTGTAAACAAGTATCTCAAATT
AAGTATGCTGCTAATAATGGAGTCCAGATGATGACTTTTGATAGTGAAGTTGAGTTGATG
AAAGTTGCCAGAGCACATCCCAAAGCAAAGTTGGTTTTGCGGATTGCCACTGATGATTCC
AAAGCAGTCTGTCGTCTCAGTGTGAAATTCGGTGCCACGCTCAGAACCAGCAGGCTCCTT
TTGGAACGGGCGAAAGAGCTAAATATCGATGTTGTTGGTGTCAGCTTCCATGTAGGAAGC
GGCTGTACCGATCCTGAGACCTTCGTGCAGGCAATCTCTGATGCCCGCTGTGTTTTTGAC
ATGGGGGCTGAGGTTGGTTTCAGCATGTATCTGCTTGATATTGGCGGTGGCTTTCCTGGA
TCTGAGGATGTGAAACTTAAATTTGAAGAGATCACCGGCGTAATCAACCCAGCGTTGGAC
AAATACTTTCCGTCAGACTCTGGAGTGAGAATCATAGCTGAGCCCGGCAGATACTATGTT
GCATCAGCTTTCACGCTTGCAGTTAATATCATTGCCAAGAAAATTGTATTAAAGGAACAG
ACGGGCTCTGATGACGAAGATGAGTCGAGTGAGCAGACCTTTATGTATTATGTGAATGAT
GGCGTCTATGGATCATTTAATTGCATACTCTATGACCACGCACATGTAAAGCCCCTTCTG
CAAAAGAGACCTAAACCAGATGAGAAGTATTATTCATCCAGCATATGGGGACCAACATGT
GATGGCCTCGATCGGATTGTTGAGCGCTGTGACCTGCCTGAAATGCATGTGGGTGATTGG
ATGCTCTTTGAAAACATGGGCGCTTACACTGTTGCTGCTGCCTCTACGTTCAATGGCTTC
CAGAGGCCGACGATCTACTATGTGATGTCAGGGCCTGCGTGGCAACTCATGCAGCAATTC
CAGAACCCCGACTTCCCACCCGAAGTAGAGGAACAGGATGCCAGCACCCTGCCTGTGTCT
TGTGCCTGGGAGAGTGGGATGAAACGCCACAGAGCAGCCTGTGCTTCGGCTAGTATTAAT
GTGTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M16650

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p25

# Metabolic_Enzyme_5_SNPs:
rs1804032; rs1049500; rs28362407; rs7558559; rs6738288; rs2302616; rs12616336; rs10490728; rs7608353; rs2302615; rs2430422; rs28362392; rs3771117; rs6753098; rs2302613; rs28362393; rs28364601; rs11538365; rs28362383; rs28362418; rs10490729; rs28362390; rs2302614; rs28362376; rs28362380; rs28362391; rs28362379; rs28362389; rs1405948; rs3752661; rs3832141; rs7559979; rs28362402; rs2357550; rs28362416; rs28362405; rs28362400; rs28362396; rs28362395; rs7599144; rs13396481; rs6708087; rs28362406; rs2009741; rs16856239; rs7609174; rs818162; rs28362433; rs28742580; rs28362424; rs28362432; rs28362425; rs28362431; rs28362434; rs28362422; rs28362429; rs28362370; rs28362423; rs28362428; rs11538369; rs11538368; rs28362411; rs11538363; rs28362397; rs28362381; rs34562944; rs7558222; rs28362374; rs28362417; rs28362385; rs34211053; rs28362372; rs3036408; rs28362386; rs34885558; rs34608521; rs14589; rs28362384; rs28362378; rs5829265; rs34007534; rs28362388; rs28362387; rs35128000; rs11538367; rs34145750; rs13401475; rs28362377; rs35616112; rs28362408; rs28362398; rs28362399; rs28362404; rs28362413; rs28362415; rs28362409; rs28362401; rs28362414; rs5829264; rs28362410; rs28362421; rs35725745; rs35284817; rs35628737; rs3134584; rs28362419; rs28362427; rs28362371; rs28362426; rs3095520; rs35759307; rs35221658; rs28362369; rs28362420; rs28362430; rs10929670; rs11694911; rs12465035; rs12692407; rs12692408; rs13000916; rs2357551; rs2430419; rs2430420; rs2463463; rs28498672; rs2884211; rs4233880; rs6432097; rs6731439; rs860169; rs885815

# Metabolic_Enzyme_5_General_References:
3595418; 2693021; 2587220; 2227439; 2318872; 1598217; 2317811; 3308908; 10623504

# Metabolic_Enzyme_5_References:
10657958; 14707; 3994674; 497223

# Metabolic_Enzyme_6_ID:
5449

# Metabolic_Enzyme_6_Name:
Spermine synthase

# Metabolic_Enzyme_6_Synonyms:
Spermidine aminopropyltransferase; SPMSY

# Metabolic_Enzyme_6_Gene_Name:
SMS

# Metabolic_Enzyme_6_Protein_Sequence:
>Spermine synthase
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP

# Metabolic_Enzyme_6_Number_of_Residues:
366

# Metabolic_Enzyme_6_Molecular_Weight:
41269

# Metabolic_Enzyme_6_Theoretical_pI:
4.62

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
S-adenosylmethioninamine + spermidine = 5'- methylthioadenosine + spermine

# Metabolic_Enzyme_6_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00330  Arginine and proline metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_6_Reaction:
S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01564:Spermine_synth

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.5.1.22

# Metabolic_Enzyme_6_GenBank_ID_Protein:
791051

# Metabolic_Enzyme_6_SwissProt_ID:
SPSY_HUMAN (P52788)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SMS

# Metabolic_Enzyme_6_Geneatlas_id:
SMS

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11123

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1107 bp
ATGCCTGGGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGAT
GGTGAGACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCG
GTGCACACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGCTTT
GCCAATTTGAGAATTTACCCACATGGATTGGTGTTGCTGGACCTTCAGAGTTATGATGGT
GATGCGCAAGGCAAAGAAGAGATCGACAGTATTTTGAACAAAGTAGAGGAAAGAATGAAA
GAATTGAGTCAGGACAGTACTGGGCGGGTGAAACGATTACCACCCATAGTGCGAGGAGGA
GCCATCGACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAATATGACATAGATGAA
GTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTACACTCGAAGCAGTTT
GGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGTGATTTGGCATATACC
CGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGATGTACTCATTCTGGGA
GGTGGAGACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCAAAGATGGTCACTATG
GTAGAGATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATGCGAAAAACGTGTGGC
GATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATAGAAGACTGTATCCCG
GTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTGATTAATGATTTGACA
GCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAGTTTCTCAGACTGATT
CTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTTACACAGGGGAACTGT
GTCAATCTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGGCGCCTGTATTGTCCT
GTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAATTGTGGGTATTTTAC
ACTGTTTGGAAGAAAGCTAAACCCTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
Z49099

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_6_Locus:
Xp22.1

# Metabolic_Enzyme_6_SNPs:
rs2238964; rs2283723; rs2238962; rs3747276; rs7891381; rs3891326; rs5951490; rs6528074; rs2238966; rs12013805; rs732946; rs5904497; rs2238958; rs5951678; rs4824217; rs2040357; rs4824171; rs732945; rs7051872; rs2238960; rs2238963; rs2238957; rs12688591; rs762702; rs5951672; rs7059727; rs5904598; rs6528077; rs1007321; rs1009643; rs16981696; rs2238961; rs2013191; rs5951676; rs7887293; rs5904600; rs7055676; rs6418750; rs768114; rs4824216; rs6633493; rs2238959; rs12012974; rs12558003; rs10521911; rs12862601; rs2239674; rs6629442; rs3747277; rs5904597; rs5904599; rs12690067; rs7883330; rs6629441; rs4824214; rs762703; rs2238967; rs12839771; rs6629443; rs5951491; rs6633490; rs4824213; rs11795630; rs6633492; rs6633500; rs2071136; rs6629444; rs6633491; rs6633496; rs2238965; rs7888401; rs5951670; rs7062138; rs5951487; rs16997426; rs7066893; rs1803034; rs4574966; rs4598383; rs4542061; rs4557827; rs3216777; rs4585875; rs34507903; rs3831664; rs41332250; rs9779369; rs7062457; rs28728153; rs7877597; rs36202602; rs6629445; rs5951677; rs41388452; rs12845823; rs3216386; rs1018768; rs11347193; rs6633497; rs11333369; rs10218267; rs12841614; rs3841770; rs4824215; rs35328914; rs5904596; rs3216385; rs10634009; rs12844253; rs12844382; rs5904498; rs6633502; rs7061670; rs12832046; rs7050034; rs35431500; rs12841626; rs12846025; rs11286374; rs12840980; rs34124534; rs5951674; rs12842132; rs12690070; rs6633494; rs34602887; rs6633495; rs34920205; rs11430711; rs35902649; rs6653656; rs12842231; rs7052122; rs35808743; rs6528076; rs5951671; rs43137; rs10702450; rs10606065; rs11373560; rs43138; rs34303071; rs12844555; rs28687310; rs12841708; rs5901691; rs11369551; rs36011591; rs5951675; rs34169359; rs12393765; rs12844043; rs10707194; rs35358672; rs35632927; rs35018744; rs35618002; rs10691989; rs13440719; rs7061351; rs43139; rs11447531; rs12844242; rs6633498; rs5951489; rs34048020; rs35831937; rs34834909; rs5901692; rs35888946; rs35705813; rs7888000; rs5951673; rs10604712; rs5951492; rs12844814; rs28403321; rs11797596; rs35504508; rs12389947; rs12832230; rs35398802; rs4394534; rs5904499; rs5904601; rs5951666; rs5951668; rs5951669; rs6528078; rs6654098; rs6654100; rs7066303

# Metabolic_Enzyme_6_General_References:
7546290; 9299240; 12665801

# Metabolic_Enzyme_6_References:
2917558; 6438490

End of HMDB00002

Beginning of HMDB00008
# Accession_No:
HMDB00008

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 12:08:47

# biospider_lastupdate:
2007-07-12 10:46:56

# Common_Name:
2-Hydroxybutyric acid

# Description:
An organic acid that is involved in propanoate metabolism.  It is found in urine of patients suffering from lactic acidosis and ketoacidosis.  2-Hydroxybutyric acid generally appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic acidemia. It was concluded from studies done in the mid 1970's that an increased NADH2/NAD ratio was the most important factor for the production of 2-hydorxybutyric acid (PMID: 168632)

# Synonyms:
(RS)-2-Hydroxybutyrate; (RS)-2-Hydroxybutyric acid; 2-Hydroxy-n-butyrate; 2-Hydroxy-n-butyric acid; 2-Hydroxybutanoate; 2-Hydroxybutanoic acid; 2-Hydroxybutyrate; 2-hydroxy-Butanoate; 2-hydroxy-Butanoic acid; 2-hydroxy-DL-Butyrate; 2-hydroxy-DL-Butyric acid; DL-2-Hydroxybutanoate; DL-2-Hydroxybutanoic acid; DL-a-Hydroxybutyrate; DL-a-Hydroxybutyric acid; a-Hydroxy-n-butyrate; a-Hydroxy-n-butyric acid; a-Hydroxybutanoate; a-Hydroxybutanoic acid; a-Hydroxybutyrate; a-Hydroxybutyric acid; alpha-hydroxy-n-butyrate; alpha-hydroxy-n-butyric acid; DL-alpha-Hydroxybutyrate; DL-alpha-Hydroxybutyric acid; alpha-Hydroxybutanoate; alpha-Hydroxybutanoic acid; alpha-Hydroxybutyrate; alpha-Hydroxybutyric acid

# Chemical_IUPAC_Name:
2-hydroxybutanoic acid

# Chemical_Formula:
C4H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00008_ZOOM.png:::119283123600066917

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00008_THUMB.png:::119283123417521278

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; carboxylic acid; alpha-hydroxyacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
104.04735

# Molecular_Weight_Avg:
104.10452

# Smiles_String_isomeric:
CCC(O)C(O)=O

# Smiles_String_canonical:
CCC(O)C(O)=O

# KEGG_Compound_ID:
C05984

# BioCyc_ID:
CPD-3564

# PubChem_CID:
11266

# PubChem_SID:
10347527; 154570; 7850103; 8158231; 671240; 72463; 6085418

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
47130

# Wikipedia_ID:
2-Hydroxybutyric acid

# METLIN_ID:
3783

# Ref_ID:
8257730; Aldrich Library of FT-IR Spectra, 1st edn., 1985, 1, 548D; Mori, K. et al., Tetrahedron, 1979, 35, 1601; Levene, P.A. et al., J. Biol. Chem., 1941, 141, 391; 168632; Duvillier, E., Ann. Chim. Phys., 1879, 17, 532; Chenault, H.K. et al., J.O.C., 1987, 52, 2608; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 854B; Horn, D.H.S. et al., J.C.S., 1954, 1460; Wong, C.H. et al., J.O.C., 1985, 50, 1992

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
600-15-7

# InChI:
InChI=1/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7)

# Synthesis_Reference:
Levene, P.A. et al., J. Biol. Chem., 1941, 141, 391; Timmermans, J. et al., Bull. Soc. Chim. Belg., 1951, 60, 424; Mori, K. et al., Tetrahedron, 1979, 35, 1601; Wong, C.H. et al., J.O.C., 1985, 50, 1992; Chenault, H.K. et al., J.O.C., 1987, 52, 2608

# Melting_Point:
44.2 oC

# Melting_Point_predicted:
25.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 484.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.16 [Predicted by ALOGPS]; -0.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00008_MSDS_1.html:::158193965507138

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00008.mol:::118425881896173852

# SDF_File_[Text]:
tbl_chemical:::HMDB00008.sdf:::119283123043518457

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00008.pdb:::119283123249554010

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041201_P01_04_BA_1DP_Presat.zip:::115651963672447263

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041201_P01_04_BA_1DP_Assinged.png:::117511839916177817

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P01_04_BA_2DHSQC_1224.png:::116476205649793546

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P01_04_BA_2DHSQC_1224.zip:::116476205650224933

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::2-hydroxybutyric acid (HMDB00008).png:::117330393645665723

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2-Hydroxybutyric acid.gif:::1132732098171546504

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00008_peaks.txt:::1156309480012812045

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2-Hydroxybutyric acid_C.gif:::1132737654994793414

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00008_peaks.txt:::1156310672113570981

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00008L.png:::117555263195855861; Medium Energy:tbl_ms:::HMDB00008M.png:::117555268487816902; High Energy:tbl_ms:::HMDB00008H.png:::117555271787217040

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	2.445 (0-4.89)	umol/mmol_creatinine	N/A	Both	Normal	168632
Blood	54.0 (8.0-80.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	85.0	uM	Adult:>18_yrs_old	Both	Normal	HMP experimental
Cerebrospinal_Fluid(CSF)	37 +/- 21 (10 - 76)	uM	Children:1-13_yrs_old	Both	Normal	8376520
Cerebrospinal_Fluid(CSF)	35.0 +/- 24.0 	uM	Adult:>18_yrs_old	Both	Normal	8412012


# Concentration_[Abnormal]:
Urine	>25.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Pyruvate dehydrogenase deficiency	OMIM 238331


# Associated_Disorders:
Pyruvate dehydrogenase deficiency

# Pathway_Names:
Glycolysis;Pyruvate metabolism;Propanoate metabolism

# Pathway_Images:
Glycolysis.jpg;;

# KEGG_Images:
map00010;map00620;map00640

# Pathway_Graphs:
Glycolysis_Graph.jpg;;

# Pathway_SBMLs:
Glycolysis.xml;;

# Metabolic_Enzyme_1_ID:
5791

# Metabolic_Enzyme_1_Name:
L-lactate dehydrogenase B chain

# Metabolic_Enzyme_1_Synonyms:
LDH-B; LDH heart subunit; LDH-H; Renal carcinoma antigen NY-REN-46

# Metabolic_Enzyme_1_Gene_Name:
LDHB

# Metabolic_Enzyme_1_Protein_Sequence:
>Llactate dehydrogenase B chain
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL

# Metabolic_Enzyme_1_Number_of_Residues:
334

# Metabolic_Enzyme_1_Molecular_Weight:
36639

# Metabolic_Enzyme_1_Theoretical_pI:
5.93

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1200083

# Metabolic_Enzyme_1_SwissProt_ID:
LDHB_HUMAN (P07195)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
LDHB

# Metabolic_Enzyme_1_Geneatlas_id:
LDHB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6541

# Metabolic_Enzyme_1_PDB_ID:
1I0Z

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>129 bp
ATGGCAACTCTTAAGGAAAAACTCATTGCACCAGTTGCGGAAGAAGAGGCAACAGTTCCA
AACAATAAGATCACTGTAGTGGGTGTTGGACAAGTTGGTATGGCGTGTGCTATCAGCATT
CTGGGAAAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X13794

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12p12.2-p12.1

# Metabolic_Enzyme_1_SNPs:
rs3575; rs1650294; rs7297559; rs1677073; rs1629683; rs1677074; rs187457; rs7953579; rs1030452; rs1650318; rs1030453; rs11046147; rs1677075; rs11833048; rs4762716; rs1650315; rs4237915; rs1677076; rs1650317; rs1650307; rs1677111; rs1650300; rs1478293; rs1540405; rs1677108; rs1650301; rs1677110; rs1650305; rs7135799; rs1650289; rs759934; rs1650313; rs1650291; rs1677085; rs1677106; rs1650287; rs1650295; rs1677080; rs1677133; rs1650293; rs1614040; rs1677127; rs1624003; rs1677107; rs1650286; rs1650310; rs1677104; rs1677132; rs1616390; rs1650312; rs1650290; rs1677079; rs12319089; rs2114897; rs759932; rs1677129; rs1613896; rs1613889; rs1650306; rs1072993; rs1677124; rs759933; rs4275672; rs4337087; rs1650314; rs1677105; rs1677131; rs1677078; rs1072992; rs12312170; rs1677134; rs1677084; rs1677083; rs1677126; rs1650296; rs1650292; rs1650288; rs962947; rs1677128; rs1677125; rs2247376; rs1677139; rs1650283; rs1677140; rs153940; rs1677137; rs1650284; rs1677135; rs1677138; rs3759235; rs11547923; rs11547925; rs35460727; rs11547922; rs11547927; rs7966339; rs15140; rs11547926; rs11547929; rs11547931; rs11319412; rs15141; rs3203471; rs5796920; rs12368587; rs28369044; rs1650304; rs1650297; rs1677109; rs34268195; rs5796916; rs5796917; rs1478297; rs34667775; rs5796919; rs36050266; rs28424005; rs1616505; rs1650309; rs33984617; rs2126883; rs34439838; rs35336445; rs33930420; rs10716782; rs7298826; rs12307094; rs12308099; rs962946; rs10681437; rs34018310; rs1677113; rs34354944; rs5002144; rs35174029; rs11444668; rs10702414; rs34052790; rs34060682; rs28520103; rs2007049; rs35987638; rs1650311; rs34994333; rs28449925; rs35346295; rs5015840; rs35497937; rs28726969; rs1626023; rs5796918; rs35044122; rs11437489; rs35473871; rs28483251; rs35049167; rs5002142; rs34381931; rs10646800; rs34522871; rs12828206; rs5002143; rs34377909; rs11046146; rs1616506; rs7486051; rs1677081; rs35109393; rs5796915; rs1427830; rs33973125; rs4762862; rs11046144; rs35783676; rs1650285; rs1677136; rs10841865; rs10841867; rs10841868; rs10841869; rs10841872; rs11046153; rs11046154; rs11046159; rs11046160; rs12824788; rs12829701; rs12830306; rs1626167; rs1626303; rs1650277; rs1650278; rs1650279; rs1650280; rs1650282; rs1677090; rs1677091; rs1677092; rs1677093; rs1677094; rs1677096; rs1677098; rs1677100; rs1677141; rs16924082; rs17629491; rs4762714; rs4762856; rs4762857; rs4762858; rs4762859; rs4762863; rs7135965; rs7297042; rs7301852; rs7301883; rs7302639; rs7303528; rs7303612; rs7303644; rs7305475; rs7316427; rs7316475; rs7316669

# Metabolic_Enzyme_1_General_References:
2930497; 3435492; 10508479; 8314553; 8462975; 1587525; 2334429; 8611651; 10211631; 9929983; 11509017

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5792

# Metabolic_Enzyme_2_Name:
L-lactate dehydrogenase C chain

# Metabolic_Enzyme_2_Synonyms:
LDH-C; LDH testis subunit; LDH-X

# Metabolic_Enzyme_2_Gene_Name:
LDHC

# Metabolic_Enzyme_2_Protein_Sequence:
>Llactate dehydrogenase C chain
MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKG
EMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSI
IPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGV
HPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYE
IIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGV
SDVVKINLNSEEEALFKKSAETLWNIQKDLIF

# Metabolic_Enzyme_2_Number_of_Residues:
332

# Metabolic_Enzyme_2_Molecular_Weight:
36312

# Metabolic_Enzyme_2_Theoretical_pI:
7.53

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Possible role in sperm motility

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_2_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_2_GenBank_ID_Protein:
307120

# Metabolic_Enzyme_2_SwissProt_ID:
LDHC_HUMAN (P07864)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
LDHC

# Metabolic_Enzyme_2_Geneatlas_id:
LDHC

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6544

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>999 bp
ATGTCAACTGTCAAGGAGCAGCTAATTGAGAAGCTAATTGAGGATGATGAAAACTCCCAG
TGTAAAATTACTATTGTTGGAACTGGTGCCGTAGGCATGGCTTGTGCTATTAGTATCTTA
CTGAAGGATTTGGCTGATGAACTTGCCCTTGTTGATGTTGCATTGGACAAACTGAAGGGA
GAAATGATGGATCTTCAGCATGGCAGTCTTTTCTTTAGTACTTCAAAGGTTACTTCTGGA
AAAGATTACAGTGTATCTGCAAACTCCAGAATAGTTATTGTCACAGCAGGTGCAAGGCAG
CAGGAGGGAGAAACTCGCCTTGCCCTGGTCCAACGTAATGTGGCTATAATGAAAATAATC
ATTCCTGCCATAGTCCATTATAGTCCTGATTGTAAAATTCTTGTTGTTTCAAATCCAGTG
GATATTTTGACATATATAGTCTGGAAGATAAGTGGCTTACCTGTAACTCGTGTAATTGGA
AGTGGTTGTAATCTAGACTCTGCCCGTTTCCGTTACCTAATTGGAGAAAAGTTGGGTGTC
CACCCCACAAGCTGCCATGGTTGGATTATTGGAGAACATGGTGATTCTAGTGTGCCCTTA
TGGAGTGGGGTGAATGTTGCTGGTGTTGCTCTGAAGACTCTGGACCCTAAATTAGGAACG
GATTCAGATAAGGAACACTGGAAAAATATCCATAAACAAGTTATTCAAAGTGCCTATGAA
ATTATCAAGCTGAAGGGGTATACCTCTTGGGCTATTGGACTGTCTGTGATGGATCTGGTA
GGATCCATTTTGAAAAATCTTAGGAGAGTGCACCCAGTTTCCACCATGGTTAAGGGATTA
TATGGAATAAAAGAAGAACTCTTTCTCAGTATCCCTTGTGTCTTGGGGCGGAATGGTGTC
TCAGATGTTGTGAAAATTAACTTGAATTCTGAGGAGGAGGCCCTTTTCAAGAAGAGTGCA
GAAACACTTTGGAATATTCAAAAGGATCTAATATTTTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J02938

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11p15.5-p15.3

# Metabolic_Enzyme_2_SNPs:
rs16935436; rs1881717; rs12293002; rs2037868; rs1908560; rs2056781; rs2896527; rs2403280; rs1406580; rs2658566; rs7111815; rs2643856; rs2721126; rs2658551; rs11024647; rs3740713; rs12270402; rs10832934; rs7938942; rs12289603; rs2658548; rs4757662; rs10766478; rs16935432; rs16935431; rs16935424; rs2403298; rs2698563; rs12416742; rs11606494; rs2056783; rs2698566; rs7110605; rs10766477; rs11024648; rs2698558; rs6486427; rs35593189; rs2056782; rs4757664; rs2643857; rs2698568; rs2658549; rs11024651; rs12282669; rs11024649; rs968895; rs1848049; rs2658553; rs12576249; rs4757663; rs11605386; rs3809096; rs3809098; rs4757660; rs7938267; rs3809097; rs7951953; rs4757656; rs1506520; rs4757655; rs11558332; rs11558333; rs2658565; rs3740714; rs10610261; rs12807225; rs11292121; rs2463909; rs35077834; rs4756943; rs11024652; rs11024657; rs35754271; rs35064545; rs11325380; rs34480310; rs33998563; rs2056784; rs2643871; rs34279411; rs36113234; rs1318593; rs7481716; rs2643855; rs2721120; rs11024653; rs35128109; rs4628652; rs12806009; rs11313322; rs184855; rs4990347; rs1908561; rs2643859; rs34485747; rs36038254; rs35126672; rs35017114; rs35689913; rs34109624; rs35720604; rs35770509; rs34907251; rs34630228; rs35915766; rs12803458; rs34176196; rs5790036; rs4990348; rs11024650; rs1506519; rs2698562; rs34844393; rs34305958; rs3074202; rs11024655; rs34903699; rs4990349; rs12801224; rs7112151; rs2698569; rs2698557; rs35478086; rs4990345; rs1908562; rs11308924; rs2658550; rs35313043; rs12795955; rs35861956; rs35617285; rs36043375; rs2721125; rs34960411; rs1848048; rs34287236; rs35857834; rs33993685; rs34546967; rs11024656; rs2254195; rs5790037; rs36045982; rs34500057; rs4990346; rs171495; rs11321502; rs34884188; rs35134819; rs2698561; rs35976847; rs187227; rs34511927; rs35749455; rs2721124; rs35284710; rs2643860; rs28729286; rs2643872; rs35299578; rs34684673; rs35515498; rs12799374; rs35192552; rs7115524; rs189660; rs2643858; rs7111938; rs34515949; rs4757659; rs4757661; rs4757658; rs4757657; rs10832932; rs11024643; rs11024645; rs11605559; rs12269752; rs16935411; rs16935413; rs1881716; rs2721121; rs34305721; rs34546419; rs35864573; rs3758680; rs3758681; rs3758682; rs3758683; rs3781641; rs4757653; rs6486425

# Metabolic_Enzyme_2_General_References:
2440048; 2930531

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5793

# Metabolic_Enzyme_3_Name:
L-lactate dehydrogenase A chain

# Metabolic_Enzyme_3_Synonyms:
LDH-A; LDH muscle subunit; LDH-M; Proliferation-inducing gene 19 protein; Renal carcinoma antigen NY-REN-59

# Metabolic_Enzyme_3_Gene_Name:
LDHA

# Metabolic_Enzyme_3_Protein_Sequence:
>Llactate dehydrogenase A chain
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF

# Metabolic_Enzyme_3_Number_of_Residues:
332

# Metabolic_Enzyme_3_Molecular_Weight:
36689

# Metabolic_Enzyme_3_Theoretical_pI:
8.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_3_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_3_GenBank_ID_Protein:
34313

# Metabolic_Enzyme_3_SwissProt_ID:
LDHA_HUMAN (P00338)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
LDHA

# Metabolic_Enzyme_3_Geneatlas_id:
LDHA

# Metabolic_Enzyme_3_hgnc_id:
HGNC:6535

# Metabolic_Enzyme_3_PDB_ID:
1I10

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>999 bp
ATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAG
AATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTA
ATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGA
GAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGC
AAAGACTATAATGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAG
CAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCGTAACGTGAACATATTTAAATTCATC
ATTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTG
GATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGA
AGTGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTGATGGGGGAAAGGCTGGGAGTT
CACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTA
TGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTAGGGACT
GATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAG
GTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGATTTGGCA
GAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAGGGTCTT
TACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAATGGAATC
TCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCA
GATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X02152

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.4

# Metabolic_Enzyme_3_SNPs:
rs5030621; rs4820; rs6498; rs7932887; rs7111748; rs2403279; rs1969565; rs2249631; rs1830425; rs1881716; rs1830426; rs4757652; rs6486425; rs3781641; rs10832932; rs2896526; rs4274186; rs7121244; rs12284013; rs12274651; rs10766475; rs3758680; rs10832928; rs10832931; rs16935411; rs10766476; rs1969563; rs11601413; rs7117399; rs12576300; rs10832929; rs10832933; rs1969564; rs16935413; rs7120485; rs7130990; rs7947664; rs1969562; rs11024644; rs6486424; rs7101840; rs10832930; rs7128549; rs7129689; rs3758682; rs2403278; rs3758683; rs3758681; rs4757650; rs6486423; rs11553874; rs34305721; rs11553873; rs11553866; rs11553870; rs12790695; rs11553865; rs7107861; rs12278153; rs4757651; rs11553862; rs35609290; rs34692667; rs12293161; rs14790; rs14789; rs35726777; rs35873857; rs35510986; rs11024642; rs35960334; rs35254161; rs12788225; rs11024645; rs12221941; rs34970587; rs10562494; rs12221918; rs12221905; rs11024643; rs33912958; rs5790035; rs11601409; rs35073059; rs11024641; rs6144242; rs34302007; rs10554414; rs10684351; rs12789257; rs6144241; rs35006409; rs35938126; rs34740438; rs35797685; rs11403792; rs35341031; rs11383902; rs35007005; rs10832927; rs10832934; rs11024640; rs11024647; rs11024649; rs11605386; rs12269752; rs12578098; rs2037868; rs3740714; rs3809096; rs3809097; rs3809098; rs4757653; rs4757661; rs7106099

# Metabolic_Enzyme_3_General_References:
3838278; 3000353; 1959923; 10508479; 1445373; 7908613

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5794

# Metabolic_Enzyme_4_Name:
L-lactate dehydrogenase A-like 6B

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
LDHAL6B

# Metabolic_Enzyme_4_Protein_Sequence:
>Llactate dehydrogenase Alike 6
BMSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIE
RFTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSP
FTKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPH
CKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWIL
GEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSW
AIGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTP
EEEAHLKKSAKTLWEIQNKLKL

# Metabolic_Enzyme_4_Number_of_Residues:
381

# Metabolic_Enzyme_4_Molecular_Weight:
41943

# Metabolic_Enzyme_4_Theoretical_pI:
8.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  anaerobic glycolysis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
(S)-lactate + NAD(+) = pyruvate + NADH

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00272  Cysteine metabolism;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_4_Reaction:
(S)-lactate + NAD+ = pyruvate + NADH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02866:Ldh_1_C;
PF00056:Ldh_1_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.27

# Metabolic_Enzyme_4_GenBank_ID_Protein:
12331000

# Metabolic_Enzyme_4_SwissProt_ID:
LDH6B_HUMAN (Q9BYZ2)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
LDHAL6B

# Metabolic_Enzyme_4_Geneatlas_id:
LDHAL6B

# Metabolic_Enzyme_4_hgnc_id:
HGNC:21481

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1146 bp
ATGAGTTGGACTGTGCCTGTTGTGCGGGCCAGCCAGAGAGTGAGCTCGGTGGGAGCGAAT
TTCCTATGCCTGGGGATGGCCCTGTGTCCGCGTCAAGCAACGCGCATCCCGCTCAACGGC
ACCTGGCTCTTCACCCCCGTGAGCAAGATGGCGACTGTGAAGAGTGAGCTTATTGAGCGT
TTCACTTCCGAGAAGCCCGTTCATCACAGTAAGGTCTCCATCATAGGAACTGGATCGGTG
GGCATGGCCTGCGCTATCAGCATCTTATTAAAAGGCTTGAGTGATGAACTTGCCCTTGTG
GATCTTGATGAAGACAAACTGAAGGGTGAGACGATGGATCTTCAACATGGCAGCCCTTTC
ACGAAAATGCCAAATATTGTTTGTAGCAAAGATTACTTTGTCACAGCAAACTCCAACCTA
GTGATTATCACAGCAGGTGCACGCCAAGAAAAGGGAGAAACGCGCCTTAATTTAGTCCAG
CGAAATGTGGCCATCTTCAAGTTAATGATTTCCAGTATTGTCCAGTACAGCCCCCACTGC
AAACTGATTATTGTTTCCAATCCAGTGGATATCTTAACTTATGTAGCTTGGAAGTTGAGT
GCATTTCCCAAAAACCGTATTATTGGAAGCGGCTGTAATCTGGATACTGCTCGTTTTCGT
TTCTTGATTGGACAAAAGCTTGGTATCCATTCTGAAAGCTGCCATGGATGGATCCTCGGA
GAGCATGGAGACTCAAGTGTTCCTGTGTGGAGTGGAGTGAACATAGCTGGTGTCCCTTTG
AAGGATCTGAACTCTGATATAGGAACTGATAAAGATCCTGAGCAATGGAAAAATGTCCAC
AAAGAAGTGACTGCAACTGCCTATGAGATTATTAAAATGAAAGGTTATACTTCTTGGGCC
ATTGGCCTATCTGTGGCCGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAATACAT
CCAGTTTCCACCATAATTAAGGGCCTCTATGGAATAGATGAAGAAGTATTCCTCAGTATT
CCTTGTATCCTGGGAGAGAACGGTATTACCAACCTTATAAAGATAAAGCTGACCCCTGAA
GAAGAGGCCCATCTGAAAAAAAGTGCAAAAACACTCTGGGAAATTCAGAATAAGCTTAAG
CTTTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AY009108

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_4_Locus:
15q22.2

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
Not Available

# Metabolic_Enzyme_4_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8617

# Macromolecular_Interacting_Partner_1_Name:
UEVLD protein

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
UEVLD

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>UEVLD protein
MEFDCEGLRRLLGKYKFRDLTVEELRNVNVFFPHFKYSMDTYGNTYNIPIRFWILDSHPF
APPICFLKPTANMGILVGKHVDAQGRIYLPYLQNWSHPKSVIVGLIKEMIAKFQEELPMY
SLSSSDEARQVDLLAYIAKITEGVSDTNSKSWANHENKTVNKITVVGGGELGIACTLAIS
AKGIADRLVLLDLSEGTKGATMDLEIFNLPNVEISKDLSASAHSKVVIFTVNSLGSSQSY
LDVVQSNVDMFRALVPALGHYSQHSVLLVASQPVEIMTYVTWKLSTFPANRVIGIGCNLD
SQRLQYIITNVLKAQTSGKEVWVIGEQGEDKVLTWSGQEEVVSHTSQVQLSNRDIMI

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
357

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
39778

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.42

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  lactate dehydrogenase activity
Function:  L-lactate dehydrogenase activity
 ||
>>>
 Process:  cellular physiological process
Process:  transport
Process:  protein transport
Process:  ubiquitin cycle
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  generation of precursor metabolites and energy
Process:  energy derivation by oxidation of organic compounds
Process:  main pathways of carbohydrate metabolism
Process:  tricarboxylic acid cycle intermediate metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Energy production and conversion

# Macromolecular_Interacting_Partner_1_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00056:Ldh_1_N
PF05743:UEV

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
40555769

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
Q6P2F0_HUMAN (Q6P2F0)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
UEVLD

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
UEVLD

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:30866

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1074 bp
ATGGAGTTCGACTGCGAGGGCCTGAGACGGCTGCTTGGCAAGTACAAGTTCAGGGACCTA
ACTGTGGAAGAACTAAGGAATGTAAATGTATTTTTCCCACATTTCAAATATTCCATGGAC
ACCTATGGTAATACATATAACATACCAATTCGTTTCTGGATTTTGGATTCTCACCCTTTC
GCTCCCCCTATTTGCTTCTTGAAGCCAACTGCAAATATGGGAATCTTAGTCGGAAAACAT
GTGGATGCTCAAGGCAGAATATATTTGCCCTATCTCCAAAACTGGAGCCATCCTAAATCT
GTCATTGTTGGATTAATTAAAGAAATGATTGCCAAGTTTCAAGAGGAACTTCCCATGTAT
TCTCTATCATCATCTGATGAGGCACGGCAGGTAGACTTGCTAGCCTATATTGCAAAAATC
ACTGAAGGTGTTTCAGATACAAATTCAAAGAGCTGGGCAAATCATGAGAATAAAACAGTC
AATAAAATTACTGTGGTTGGAGGTGGAGAACTCGGTATTGCCTGCACATTAGCAATTTCA
GCAAAGGGTATTGCAGACAGGCTTGTCCTCTTAGACCTCTCAGAAGGGACTAAAGGAGCC
ACGATGGACCTTGAAATCTTCAACCTTCCTAATGTGGAGATCAGCAAAGATTTGTCTGCC
TCTGCTCATTCCAAGGTGGTGATCTTCACAGTCAACTCTTTGGGTAGTTCTCAGTCGTAC
CTTGATGTGGTACAGAGCAATGTGGATATGTTCAGAGCCCTTGTCCCAGCTCTGGGACAT
TATAGTCAACACAGTGTCCTGCTCGTTGCATCTCAACCAGTGGAAATCATGACCTATGTA
ACATGGAAACTGAGTACATTTCCTGCAAATCGAGTGATCGGAATTGGATGTAATCTGGAT
TCACAGAGATTACAGTATATTATTACAAATGTTTTGAAGGCACAGACTTCAGGCAAAGAA
GTATGGGTTATTGGCGAGCAAGGAGAAGACAAAGTGCTCACATGGAGTGGCCAAGAAGAA
GTAGTGAGTCATACCTCTCAAGTGCAGCTGTCCAACAGGGATATTATGATATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
BC064566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs10500835; rs34242612; rs4756952; rs7950602; rs7107057; rs4756951; rs6486434; rs10832940; rs7105889; rs7109314; rs2305166; rs10741747; rs11024718; rs11024717; rs11024715; rs7928508; rs10766485; rs4756949; rs4756950; rs16935539; rs11024716; rs2271080; rs7942733; rs10741745; rs2271079; rs12577416; rs12420702; rs16935575; rs12577346; rs6486435; rs7119085; rs11024706; rs10832943; rs2305167; rs11822477; rs12577619; rs11024711; rs7951508; rs16935543; rs12418907; rs11024709; rs1857907; rs10219146; rs7952284; rs11024725; rs10832942; rs4757672; rs7130163; rs12224694; rs7101733; rs16935538; rs11024719; rs7108487; rs7483340; rs11024722; rs7109496; rs10832946; rs17392588; rs12420882; rs12225461; rs4756948; rs7102116; rs11825249; rs10219166; rs7940645; rs12421803; rs10741746; rs16935559; rs11024723; rs12419223; rs12225037; rs10832947; rs10832944; rs16935541; rs12803251; rs12418726; rs10766486; rs11024724; rs7107204; rs16935557; rs12049912; rs12289644; rs10832941; rs7116316; rs3781639; rs10832945; rs4623881; rs7106180; rs12289223; rs7926511; rs13377281; rs33991194; rs193330; rs11445836; rs968711; rs12794725; rs35449210; rs10638102; rs11024713; rs34853816; rs12049909; rs11024703; rs34081721; rs34109550; rs35749759; rs12796224; rs33928228; rs3214765; rs4756947; rs34523639; rs7948475; rs12796202; rs28607050; rs4417245; rs12790354; rs11600760; rs10683299; rs12795883; rs35059773; rs12049851; rs7119501; rs35960383; rs7934311; rs968712; rs11024705; rs34474192; rs34736014; rs12790143; rs11024726; rs35798683; rs11024712; rs34170647; rs12807106; rs34286769; rs34951254; rs35410505; rs12792924; rs35715013; rs12280959; rs35038497; rs12225251; rs11449292; rs36022682; rs11024704; rs35032055; rs12278992; rs35875343; rs5790040; rs12795875; rs35900814; rs12223260; rs11024721; rs35864596; rs12226584; rs11024714; rs34120372; rs11600244; rs34327848; rs36054394; rs35906676; rs35944144; rs34900962; rs4757671; rs34888550; rs35110669; rs11394988; rs3837379; rs7116220; rs34434085; rs34297128; rs10540605; rs35315027; rs3832729; rs34999373; rs11024720; rs35047705; rs35274706; rs34545423; rs11602888; rs34585786; rs11603372; rs12574808; rs35702732; rs12421881; rs11302053; rs34139368; rs35384688; rs12804077; rs12290527; rs34587461; rs34646785; rs11443134; rs34386323; rs11602699; rs34857682; rs34561317; rs11024710; rs12222154; rs35537932; rs10734260; rs4757670; rs34226030; rs10444226; rs11024701; rs12287275; rs12785294; rs1395319; rs1395320; rs1530565; rs1547497; rs1857908; rs1857909; rs1979051; rs1983124; rs2088184; rs2121386; rs2174614; rs2292177; rs2292178; rs2292179; rs3802965; rs3802966; rs4436523; rs4757673; rs6416020; rs7931630

# Macromolecular_Interacting_Partner_1_General_References:
12477932

# Macromolecular_Interacting_Partner_1_References:
Not Available

End of HMDB00008

Beginning of HMDB00010
# Accession_No:
HMDB00010

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-01-09 14:07:54

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
2-Methoxyestrone

# Description:
A steroid derivative that is a byproduct of estrone and 2-hydroxyestrone metabolism.  It is part of the androgen and estrogen metabolic pathway.

# Synonyms:
2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one; 2-Hydroxyestrone 2-methyl ether; 2-Methoxy-17-oxoestra-1,3,5(10)-trien-3-ol; 2-Methoxy-3-hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one; 3-hydroxy-2-methoxy-Estra-1,3,5(10)-trien-17-one; methoxy-Estrone

# Chemical_IUPAC_Name:
3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

# Chemical_Formula:
C19H24O3

# Chemical_Structure:
tbl_chemical:::HMDB00010_ZOOM.png:::119283124960011285

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00010_THUMB.png:::119283124753353551

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; phenol or hydroxyhetarene; alkyl aryl ether; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
300.17255

# Molecular_Weight_Avg:
300.39209

# Smiles_String_isomeric:
COC1=CC2=C(CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@H]23)C=C1O

# Smiles_String_canonical:
COC1=CC2=C(CCC3C4CCC(=O)C4(C)CCC23)C=C1O

# KEGG_Compound_ID:
C05299

# BioCyc_ID:
ESTRONE-SULFATE

# PubChem_CID:
440624

# PubChem_SID:
7683; 10298626; 841376

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
2578

# Ref_ID:
9812172; Kraychy, S., J.A.C.S., 1957, 79, 754 and 1959, 81, 1702, (ethers); Miyazaki, M. et al., J.O.C., 1968, 33, 662, (sulfate); Shimada, K. et al., J. Chromatogr., 1979, 178, 350, (HPLC); 6863476; 462497; Gelbke, H.P. et al., Steroids, 1973, 21, 205, (synthesis, PMR); Douglas, G.H. et al., J. Med. Chem., 1966, 9, 27, (synthesis, UV, (+/-)-form)

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
362-08-3

# InChI:
InChI=1/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1

# Synthesis_Reference:
Fishman, J. et al., J.O.C., 1960, 25, 585; Rao, P.N. et al., J.C.S., 1961, 4769; Douglas, G.H. et al., J. Med. Chem., 1966, 9, 27; Gelbke, H.P. et al., Steroids, 1973, 21, 205; Kirk, D.N. et al., J. Chem. Res., Synop., 1983, 228

# Melting_Point:
187.0-189.5 oC

# Melting_Point_predicted:
126.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
7.49e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
3.50 [Predicted by ALOGPS]; 3.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::2-Methoxyestrone.pdf:::113256218900391369

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::2-Methoxyestrone.mol:::1132723680593329421

# SDF_File_[Text]:
tbl_chemical:::HMDB00010.sdf:::119283124031340517

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00010.pdb:::119283124579548268

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2-Methoxyestrone.gif:::1132732098375641852

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00010_peaks.txt:::115630948102412348

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2-Methoxyestrone_C.gif:::1132737655785195462

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00010_peaks.txt:::115631067313567449

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	0.005 (0.004-0.006)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9812172


# Concentration_[Abnormal]:
Urine	0.025 (0.02-0.03)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Prolactinoma	9812172


# Associated_Disorders:
Prolactinoma; Prostate Cancer

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00040;map00150;map00500;map00860

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5732

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_1_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_1_Gene_Name:
UGT1A6

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_1_Number_of_Residues:
532

# Metabolic_Enzyme_1_Molecular_Weight:
60751

# Metabolic_Enzyme_1_Theoretical_pI:
8.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_1_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT1A6

# Metabolic_Enzyme_1_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_1_Chromosome_Location:
Not Available

# Metabolic_Enzyme_1_Locus:
Not Available

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5796

# Metabolic_Enzyme_2_Name:
Catechol-O-methyltransferase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
Not Available

# Metabolic_Enzyme_2_Protein_Sequence:
>CatecholOmethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCE

# Metabolic_Enzyme_2_Number_of_Residues:
84

# Metabolic_Enzyme_2_Molecular_Weight:
9399

# Metabolic_Enzyme_2_Theoretical_pI:
4.88

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Not Available

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
1-32

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
30583089

# Metabolic_Enzyme_2_SwissProt_ID:
Q7KZP0_HUMAN (Q7KZP0)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
Not Available

# Metabolic_Enzyme_2_Geneatlas_id:
Not Available

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane

# Metabolic_Enzyme_2_Gene_Sequence:
>255 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCATGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
BT007125

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5721

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_3_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_3_Gene_Name:
UGT2B7

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_3_Number_of_Residues:
529

# Metabolic_Enzyme_3_Molecular_Weight:
60695

# Metabolic_Enzyme_3_Theoretical_pI:
8.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_3_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT2B7

# Metabolic_Enzyme_3_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_3_Locus:
4q13

# Metabolic_Enzyme_3_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_3_General_References:
2159463; 11186130

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5731

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_4_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
UGT2B17

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
61096

# Metabolic_Enzyme_4_Theoretical_pI:
8.73

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_4_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT2B17

# Metabolic_Enzyme_4_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
8798464; 9364925

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5720

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT

# Metabolic_Enzyme_5_Gene_Name:
UGT2B10

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_5_Number_of_Residues:
528

# Metabolic_Enzyme_5_Molecular_Weight:
60775

# Metabolic_Enzyme_5_Theoretical_pI:
9.40

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_5_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B10

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q13.2

# Metabolic_Enzyme_5_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_5_General_References:
8333863

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5734

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_6_Synonyms:
UDPGT

# Metabolic_Enzyme_6_Gene_Name:
UGT2B11

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_6_Number_of_Residues:
529

# Metabolic_Enzyme_6_Molecular_Weight:
61039

# Metabolic_Enzyme_6_Theoretical_pI:
9.29

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-21

# Metabolic_Enzyme_6_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_6_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2B11

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13.2

# Metabolic_Enzyme_6_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_6_General_References:
9675083

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5696

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_7_Gene_Name:
UGT2B4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_7_Number_of_Residues:
528

# Metabolic_Enzyme_7_Molecular_Weight:
60513

# Metabolic_Enzyme_7_Theoretical_pI:
8.75

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-23

# Metabolic_Enzyme_7_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_7_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT2B4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_7_Locus:
4q13

# Metabolic_Enzyme_7_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_7_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5725

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_8_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_8_Gene_Name:
UGT1A1

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
533

# Metabolic_Enzyme_8_Molecular_Weight:
59592

# Metabolic_Enzyme_8_Theoretical_pI:
8.09

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_8_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A1

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5687

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_9_Synonyms:
UDPGT

# Metabolic_Enzyme_9_Gene_Name:
UGT2B28

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_9_Number_of_Residues:
529

# Metabolic_Enzyme_9_Molecular_Weight:
60907

# Metabolic_Enzyme_9_Theoretical_pI:
8.80

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-24

# Metabolic_Enzyme_9_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_9_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2B28

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_9_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13.2

# Metabolic_Enzyme_9_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_9_General_References:
11300766

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5719

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_10_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_10_Gene_Name:
UGT1A4

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_10_Number_of_Residues:
534

# Metabolic_Enzyme_10_Molecular_Weight:
60026

# Metabolic_Enzyme_10_Theoretical_pI:
8.68

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-28

# Metabolic_Enzyme_10_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_10_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT1A4

# Metabolic_Enzyme_10_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_10_Locus:
2q37

# Metabolic_Enzyme_10_SNPs:
Not Available

# Metabolic_Enzyme_10_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5728

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_11_Gene_Name:
UGT1A3

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60339

# Metabolic_Enzyme_11_Theoretical_pI:
8.28

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_11_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A3

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1339448; 11434514

# Metabolic_Enzyme_11_References:
Not Available

End of HMDB00010

Beginning of HMDB00012
# Accession_No:
HMDB00012

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 10:30:32

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxyuridine

# Description:
2'-Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2'-hydroxyl group.  It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies.

# Synonyms:
1-(2-Deoxy-D-erythro-pentofuranosyl)uracil; 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 1-(2-deoxy-beta-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 2'-Deoxyuridine; 2'-Desoxyuridine; Deoxyribose uracil; Desoxyuridine; Uracil deoxyriboside; Uracil desoxyuridine; 1-(2-Deoxy-delta-erythro-pentofuranosyl)uracil; 1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione; 1-(2-deoxy-beta-delta-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione

# Chemical_IUPAC_Name:
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

# Chemical_Formula:
C9H12N2O5

# Chemical_Structure:
tbl_chemical:::HMDB00012_ZOOM.png:::11928312602598488

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00012_THUMB.png:::119283125822925724

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; oxo(het)arene; carboxylic acid imide, N-unsubstituted; urea; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
DNA component

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
228.07463

# Molecular_Weight_Avg:
228.20200

# Smiles_String_isomeric:
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O

# Smiles_String_canonical:
OCC1OC(CC1O)N2C=CC(=O)NC2=O

# KEGG_Compound_ID:
C00526

# BioCyc_ID:
DEOXYURIDINE

# PubChem_CID:
13712

# PubChem_SID:
832124; 12034270; 3809; 8028153; 157048; 828539; 650425; 3139591; 8160335; 825013; 832930; 7887227

# OMIM_ID:
192240

# Metagene_ID:
Not Available

# BiGG_ID:
35251

# Wikipedia_ID:
Deoxyuridine

# METLIN_ID:
5086

# Ref_ID:
Akhrem, A.A. et al., Org. Magn. Reson., 1979, 12, 247, (cmr); 15866500; 9675653; Fox, J.J. et al., Adv. Carbohydr. Chem., 1959, 14, 283, (rev); Rimerman, R.A. et al., J. Chromatogr., B: Biomed. Appl., 1993, 619, 29-35, (5'-triphosphate); Schinazi, R.F. et al., J. Med. Chem., 1978, 21, 1141, (synth, acid); Barr, P.J. et al., Tetrahedron, 1980, 36, 1269, (cryst struct); Ludwig, J. et al., Synthesis, 1982, 32-34, (5'-phosphate); 3812550; Dematte, N. et al., Comp. Biochem. Physiol., B: Comp. Biochem., 1986, 84, 11, (isol, acid); Rahman, A. et al., Acta Cryst. B, 1972, 28, 2260, (cryst struct); Sakema, S. et al., Comp. Biochem. Physiol., B: Comp. Biochem., 1985, 82, 107-109, (isol); Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 816A, (ir); Kikugawa, K. et al., Chem. Pharm. Bull., 1969, 17, 785, (synth, deriv); 6656991; Sprecher, C.A. et al., Biopolymers, 1977, 16, 2243, (cd); Komori, T. et al., Annalen, 1980, 653-668, (isol); 1906076; 3761048; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 374B, (nmr); Hruska, F.E. et al., Can. J. Chem., 1974, 52, 497, (conformn, pmr); U.S. Pat., 1966, 3 280 104, CA, 66, 38207y; Lidgren, G. et al., J. Nat. Prod., 1988, 51, 1277-1280, (2'-Deoxy-3-methyluridine); 9930567; 12638947; 2328792; 11432631

# ChEBI_ID:
16450

# CAS_Registry_Number:
951-78-0

# InChI:
InChI=1/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

# Synthesis_Reference:
Dekker, C.A. et al., Nature (London), 1950, 166, 557, (synth); Brown, D.M. et al., J.C.S., 1958, 3035, (synth); Kikugawa, K. et al., Chem. Pharm. Bull., 1969, 17, 785, (synth, deriv); Schinazi, R.F. et al., J. Med. C hem., 1978, 21, 1141, (synth, acid); B

# Melting_Point:
167 oC

# Melting_Point_predicted:
113.2 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
29.7 mg/mL [MEYLAN,WM et al. (1996)]; 90.6 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.51 [BALZARINI,JM ET AL. (1989)]

# LogP_predicted:
-1.48 [Predicted by ALOGPS]; -1.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00526.mol:::1132723801062703623

# SDF_File_[Text]:
tbl_chemical:::HMDB00012.sdf:::11928312538948400

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00012.pdb:::119283125654529650

# PDB_ID:
1BDU

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1BDU.txt:::1132720898515975048

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_presat_expanded_2.gif:::114168236979070293

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_presat.zip:::117512426329258465

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_01_HW_1DP_Assigned.png:::116414317220093214

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769.png:::114805591747188659

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769.zip:::114805591757798129

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041029_P00_01_HW_2DHSQC_769_Assigned.png:::115014524082864104

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2'-Deoxyuridine.gif:::1132732098796116951

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00012_peaks.txt:::1156309483110986814

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2'-Deoxyuridine_C.gif:::1132737657207798715

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00012_peaks.txt:::1156310675162585477

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00012L.png:::117555261809351653; Medium Energy:tbl_ms:::HMDB00012M.png:::117555266925743518; High Energy:tbl_ms:::HMDB00012H.png:::117555270818934604

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; mitochondria; nucleus

# Tissue_Location:
Bladder; Bone Marrow; Fibroblasts; Intestine; Lymphocyte; Most Tissues; Muscle; Neurons; Pancreas; Placenta; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Blood	0.052 (0.049-0.056)	umol/L	Adult:>18_yrs_old	Both	Normal	15866500
Blood	0.62 +/- 0.39	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	0.200 (0.100-0.300)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Cerebrospinal_Fluid(CSF)	0 - 0.1	uM	Adult:>18_yrs_old	Both	Normal	6656991


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Degenerative disc disease

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5801

# Metabolic_Enzyme_1_Name:
Uridine phosphorylase 1

# Metabolic_Enzyme_1_Synonyms:
UrdPase 1; UPase 1

# Metabolic_Enzyme_1_Gene_Name:
UPP1

# Metabolic_Enzyme_1_Protein_Sequence:
>Uridine phosphorylase 1
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA

# Metabolic_Enzyme_1_Number_of_Residues:
310

# Metabolic_Enzyme_1_Molecular_Weight:
33935

# Metabolic_Enzyme_1_Theoretical_pI:
7.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  uridine phosphorylase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01048:PNP_UDP_1

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1050525

# Metabolic_Enzyme_1_SwissProt_ID:
UPP1_HUMAN (Q16831)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UPP1

# Metabolic_Enzyme_1_Geneatlas_id:
UPP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12576

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>933 bp
ATGGCGGCCACGGGAGCCAATGCAGAGAAAGCTGAAAGTCACAATGATTGCCCCGTCAGA
CTTTTAAATCCAAACATAGCAAAAATGAAAGAAGATATTCTCTATCATTTCAATCTCACC
ACTAGCAGACACAATTTCCCAGCCTTGTTTGGAGATGTGAAGTTTGTGTGTGTTGGTGGA
AGCCCCTCCCGGATGAAAGCCTTCATCAGGTGCGTTGGTGCAGAGCTGGGCCTTGACTGC
CCAGGTAGAGACTATCCCAACATCTGTGCGGGAACTGACCGCTATGCCATGTATAAAGTA
GGACCGGTGCTGTCTGTCAGTCATGGTATGGGCATTCCTTCTATCTCAATCATGTTGCAT
GAGCTCATAAAGCTGCTGTACTATGCCCGGTGCTCCAACGTCACTATCATCCGCATTGGC
ACTTCTGGTGGGATAGGTCTGGAGCCCGGCACTGTGGTCATAACAGAGCAGGCAGTGGAT
ACCTGCTTCAAGGCAGAGTTTGAGCAGATTGTCCTGGGGAAGCGGGTCATCCGGAAAACG
GACCTTAACAAGAAGCTGGTGCAGGAGCTGTTGCTGTGTTCTGCAGAGCTGAGCGAGTTC
ACCACAGTGGTGGGGAACACCATGTGCACCTTGGACTTCTATGAAGGGCAAGGCCGTCTG
GATGGGGCTCTCTGCTCCTACACGGAGAAGGACAAGCAGGCGTATCTGGAGGCAGCCTAT
GCAGCCGGCGTCCGCAATATCGAGATGGAGTCCTCGGTGTTTGCCGCCATGTGCAGCGCC
TGCGGCCTCCAAGCGGCCGTGGTGTGTGTCACCCTCCTGAACCGCCTGGAAGGGGACCAG
ATCAGCAGCCCTCGCAATGTGCTCAGCGAGTACCAGCAGAGGCCGCAGCGGCTGGTGAGC
TACTTCATCAAGAAGAAACTGAGCAAGGCCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X90858

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7p12.3

# Metabolic_Enzyme_1_SNPs:
rs11971829; rs2230761; rs11975785; rs7458962; rs3752890; rs3763505; rs13240650; rs7459020; rs3752889; rs9639019; rs6947955; rs3763504; rs6463462; rs7341420; rs11768083; rs7385009; rs7341532; rs7459421; rs7458926; rs6944892; rs1554494; rs7793905; rs11981908; rs7794483; rs7794100; rs1131054; rs2230762; rs2230763; rs1131053; rs7798472; rs35041681; rs1050268; rs6463461; rs34459058; rs1050267; rs10278152; rs13227958; rs3763503; rs11552769; rs35225437; rs35686833; rs1050269; rs6947463; rs35169380; rs13308979; rs13228276; rs35985285; rs34080051; rs34017036; rs34743411; rs12668306; rs34556557; rs6974256; rs10260645; rs35450094; rs10225490; rs10263327; rs10274287; rs10279431; rs11971012; rs11973024; rs12672358; rs13241683; rs34702486; rs6951116; rs7778357; rs7784208; rs7804178; rs9648572

# Metabolic_Enzyme_1_General_References:
7488099

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5802

# Metabolic_Enzyme_2_Name:
Cytidine deaminase

# Metabolic_Enzyme_2_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_2_Gene_Name:
CDA

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
146

# Metabolic_Enzyme_2_Molecular_Weight:
16185

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_2_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CDA

# Metabolic_Enzyme_2_Geneatlas_id:
CDA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_2_PDB_ID:
1MQ0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.2-p35

# Metabolic_Enzyme_2_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_2_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5317

# Metabolic_Enzyme_3_Name:
Thymidine kinase, cytosolic

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
TK1

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine kinase, cytosolic
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDR
NTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTV
IVAALDGTFQRKPFGAILNLV
PLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGA
DKYHSVCRLCYFKKASGQPAGPDNKENCPVPG
KPGEAVAARKLFAPQQILQCSPAN

# Metabolic_Enzyme_3_Number_of_Residues:
234

# Metabolic_Enzyme_3_Molecular_Weight:
25469

# Metabolic_Enzyme_3_Theoretical_pI:
8.61

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  deoxynucleoside kinase activity
Function:  thymidine kinase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
ATP + thymidine = ADP + thymidine 5'- phosphate

# Metabolic_Enzyme_3_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00265:TK

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
339709

# Metabolic_Enzyme_3_SwissProt_ID:
KITH_HUMAN (P04183)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TK1

# Metabolic_Enzyme_3_Geneatlas_id:
TK1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11830

# Metabolic_Enzyme_3_PDB_ID:
1XBT

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>705 bp

ATGAGCTGCATTAACCTGCCCACTGTGCTGCCCGGCTCCCCCAGCAAGACCCGGGGGCA
GATCCAGGTGA
TTCTCGGGCCGATGTTCTCAGGAAAAAGCACAGAGTTGATGAGACGCG
TCCGTCGCTTCCAGATTGCTCA
GTACAAGTGCCTGGTGATCAAGTATGCCAAAGACACT
CGCTACAGCAGCAGCTTCTGCACACATGACCGG
AACACCATGGAGGCGCTGCCCGCCTG
CCTGCTCCGAGACGTGGCCCAGGAGGCCCTGGGCGTGGCTGTCA
TAGGCATCGACGAGG
GGCAGTTTTTCCCTGACATCATGGAGTTCTGCGAGGCCATGGCCAACGCCGGGAA
GACC
GTAATTGTGGCTGCACTGGATGGGACCTTCCAGAGGAAGCCATTTGGGGCCATCCTGAAC
CTGGTG
CCGCTGGCCGAGAGCGTGGTGAAGCTGACGGCGGTGTGCATGGAGTGCTTCCG
GGAAGCCGCCTATACCA
AGAGGCTCGGCACAGAGAAGGAGGTCGAGGTGATTGGGGGAG
CAGACAAGTACCACTCCGTGTGTCGGCT
CTGCTACTTCAAGAAGGCCTCAGGCCAGCCT
GCCGGGCCGGACAACAAAGAGAACTGCCCAGTGCCAGGA
AAGCCAGGGGAAGCCGTGGC
TGCCAGGAAGCTCTTTGCCCCACAGCAGATTCTGCAATGCAGCCCTGCCA
ACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
K02581

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17q23.2-q25.3

# Metabolic_Enzyme_3_SNPs:
rs1143697; rs35330043; rs1065767; rs1065769; rs1065768; rs11653181; rs7217417; rs9897269; rs2854704; rs2854701; rs12452081; rs2854702; rs2661679; rs2006130; rs7217042; rs1811086; rs762542; rs735170; rs8072887; rs12601427; rs2515693; rs16970907; rs762541; rs9915560; rs11657629; rs9893988; rs4306580; rs2661680; rs12453050; rs9894890; rs2661681; rs2010371; rs12232476; rs1132543; rs34529187; rs1052931; rs11869997; rs8081639; rs34860308; rs36059491; rs2854703; rs28736712; rs7214459; rs2613510; rs7213946; rs2661678; rs28489345; rs35952086; rs2661682; rs2613511; rs11657714; rs762543; rs34727843; rs9899622; rs35275137; rs12602793; rs9896067; rs1071664; rs1079170; rs1109807; rs1109808; rs11654483; rs12449983; rs12450989; rs12936854; rs16970909; rs17640750; rs2292235; rs2467573; rs3794742; rs3794743; rs3829575; rs4465660; rs4789546; rs870355; rs906555; rs9891101; rs9897765; rs9899032; rs9902154; rs9903350

# Metabolic_Enzyme_3_General_References:
6549046; 3301530; 9575153

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5803

# Metabolic_Enzyme_4_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_4_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_4_Gene_Name:
AICDA

# Metabolic_Enzyme_4_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_4_Number_of_Residues:
198

# Metabolic_Enzyme_4_Molecular_Weight:
23954

# Metabolic_Enzyme_4_Theoretical_pI:
9.66

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_4_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AICDA

# Metabolic_Enzyme_4_Geneatlas_id:
AICDA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_4_Locus:
12p13

# Metabolic_Enzyme_4_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_4_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5804

# Metabolic_Enzyme_5_Name:
Uridine phosphorylase 2

# Metabolic_Enzyme_5_Synonyms:
UrdPase 2; UPase 2

# Metabolic_Enzyme_5_Gene_Name:
UPP2

# Metabolic_Enzyme_5_Protein_Sequence:
>Uridine phosphorylase 2
MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVK
FVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPS
ISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDN
IVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD
YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR
PQLLISNFIRRRLGLCD

# Metabolic_Enzyme_5_Number_of_Residues:
317

# Metabolic_Enzyme_5_Molecular_Weight:
35528

# Metabolic_Enzyme_5_Theoretical_pI:
6.66

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  uridine phosphorylase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates

# Metabolic_Enzyme_5_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_5_Reaction:
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01048:PNP_UDP_1

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.2.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
32306848

# Metabolic_Enzyme_5_SwissProt_ID:
UPP2_HUMAN (O95045)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UPP2

# Metabolic_Enzyme_5_Geneatlas_id:
UPP2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:23061

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>954 bp
ATGGCTTCAGTTATACCTGCCTCCAATAGGTCCATGAGATCTGACAGGAATACATATGTT
GGAAAAAGGTTTGTTCACGTTAAAAATCCTTACTTGGATTTGATGGATGAAGACATTCTC
TATCACTTGGATCTGGGAACAAAAACACACAACCTACCAGCAATGTTCGGAGATGTAAAG
TTCGTCTGTGTCGGTGGGAGCCCCAACAGAATGAAAGCATTTGCACTGTTTATGCACAAG
GAGCTCGGGTTTGAGGAAGCTGAAGAAGACATAAAAGACATCTGTGCTGGGACAGACAGA
TACTGTATGTACAAAACCGGGCCTGTGCTCGCCATCAGTCACGGCATGGGCATCCCCTCC
ATTTCTATTATGCTTCATGAACTCATCAAATTACTCCACCATGCACGGTGCTGCGATGTC
ACCATTATTAGAATCGGTACATCAGGGGGAATAGGGATGGCACCAGGACGTGTTGTAATA
ACGGATATAGCTGTAGACTCCTTCTTTAAGCCCCGGTTTGAACAGGTCATTTTGGACAAC
ATTGTCACCCGAAGTACTGAACTGGACAAAGAACTGTCTGAAGAACTGTTCAACTGTAGC
AAAGAAATCCCCAACTTCCCAACCCTCGTTGGACATACAATGTGTACCTATGATTTTTAT
GAAGGCCAAGGGCGACTAGATGGAGCACTGTGCTCCTTTTCCAGAGAAAAAAAGTTAGAC
TACTTGAAGAGAGCATTTAAAGCTGGTGTCAGGAATATTGAAATGGGAATCTACAGTGTT
TGCAGTATGTGTGGACTCTGTGGTCTAAAAGCTGCTGTGGTCTGTGTGACACTTCTCGAC
AGACTCGACTGTGATCAGATCAACTTGCCTCATGATGTCCTGGTGGAGTACCAGCAACGG
CCTCAGCTCCTAATCTCCAACTTCATCAGACGGCGGCTTGGACTTTGTGACTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AY225131

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2q24.1

# Metabolic_Enzyme_5_SNPs:
rs6710480; rs7561584; rs10186677; rs1160638; rs758279; rs1860164; rs765955; rs1860163; rs1860165; rs2098044; rs2190959; rs1329342; rs7593877; rs7591044; rs2159205; rs6437124; rs740553; rs10804388; rs7602989; rs4664918; rs7573932; rs4664922; rs6710348; rs2355162; rs1160637; rs7608061; rs6437129; rs1410958; rs6747631; rs758278; rs7593795; rs6757689; rs4664238; rs6731028; rs10755053; rs6437128; rs11895999; rs6437125; rs2355163; rs6739192; rs12465358; rs6706559; rs4664920; rs10171627; rs6437126; rs6746349; rs10192905; rs758280; rs6710054; rs4664236; rs7560174; rs725448; rs6724825; rs2355164; rs4664240; rs7582575; rs6739665; rs10182269; rs13401601; rs10204779; rs7607379; rs6745721; rs2024127; rs6755190; rs6759860; rs10933455; rs16842547; rs6723729; rs6749356; rs17420138; rs7604678; rs7355662; rs10187183; rs16842512; rs13418261; rs714566; rs981727; rs6731503; rs1468522; rs11690619; rs6718722; rs10165794; rs13388942; rs11684639; rs7567537; rs740551; rs13388607; rs7557328; rs7566548; rs971008; rs2024128; rs10460441; rs7594090; rs12104561; rs2074954; rs16842385; rs7565931; rs13020547; rs17419998; rs7567609; rs13406519; rs6437131; rs981729; rs9678256; rs12465287; rs6437130; rs10211094; rs1160636; rs7575665; rs7571138; rs10933457; rs13413757; rs13398821; rs6742818; rs1080178; rs7570575; rs16842429; rs1080177; rs16841677; rs740552; rs7560277; rs11902596; rs7578519; rs2079656; rs9288704; rs7577260; rs6734235; rs7577191; rs7560781; rs6437127; rs6437132; rs13418476; rs10933458; rs2052031; rs13032622; rs17491995; rs1080176; rs6758681; rs2079657; rs16842426; rs768364; rs7603318; rs11676875; rs6731053; rs6759948; rs13409467; rs7424774; rs10195028; rs11691557; rs16842383; rs11684410; rs2215176; rs13420712; rs4664239; rs981728; rs16842594; rs16842499; rs16842434; rs6712771; rs12996955; rs10180447; rs13396285; rs2108816; rs13400332; rs13019560; rs6744349; rs7597068; rs10193154; rs12992208; rs11690352; rs1329340; rs16842466; rs16842508; rs1019104; rs6707195; rs13395880; rs10173292; rs11691556; rs11690279; rs4664921; rs13414112; rs11679887; rs13431709; rs16842523; rs13024527; rs13383975; rs12474160; rs13429651; rs16842633; rs6752906; rs6729821; rs13391604; rs13383727; rs7602627; rs2190953; rs16842411; rs6752601; rs4664919; rs7424761; rs7424394; rs10205037; rs13396135; rs7560997; rs13007683; rs11892606; rs4664237; rs10173376; rs7605276; rs10196394; rs13431782; rs12052397; rs1329341; rs16842593; rs16842387; rs13404592; rs6707197; rs17491974; rs10178987; rs12623742; rs988059; rs11695349; rs16842413; rs6728626; rs13023991; rs2355165; rs7599139; rs16842494; rs10204540; rs10202707; rs10204766; rs13410444; rs7591370; rs10176046; rs13023813; rs6437136; rs10174157; rs6713525; rs7576829; rs6707705; rs6437135; rs7606259; rs6437139; rs13419905; rs10933459; rs10804389; rs6760699; rs6734022; rs6755018; rs6437134; rs6437137; rs6437138; rs6437133; rs6713742; rs1263152; rs4485523; rs13406552; rs2074955; rs7606365; rs17603277; rs16842609; rs6730188; rs6733576; rs13418976; rs6709528; rs7574417; rs11894922; rs7574058; rs7585982; rs6756966; rs7609063; rs4319893; rs4664924; rs1468523; rs4637056; rs4485524; rs986501; rs7568477; rs7559298; rs10190321; rs4637061; rs10182253; rs10209610; rs13010795; rs10489993; rs7568468; rs34393954; rs6749648; rs10199024; rs10182289; rs13409464; rs13007885; rs10197249; rs12987618; rs7559218; rs16842619; rs11692274; rs12466382; rs7586185; rs13415348; rs10176676; rs7558513; rs10192781; rs7602749; rs6749740; rs7595641; rs10172773; rs6720259; rs10489992; rs12465565; rs6437140; rs3732279; rs7563995; rs35667202; rs10649233; rs13395543; rs11451567; rs34328148; rs2190957; rs33978782; rs11688272; rs10171334; rs35035189; rs34236762; rs34079541; rs10167313; rs35643988; rs34346859; rs13392641; rs10184749; rs28529746; rs34051841; rs7370027; rs3046335; rs10206347; rs34858406; rs13430174; rs13401709; rs10588032; rs2190958; rs11385969; rs35445098; rs12994444; rs35914373; rs10669271; rs13011897; rs11368509; rs6710159; rs5835683; rs34251600; rs13415506; rs7596946; rs34401967; rs34727822; rs35725448; rs35506673; rs28612352; rs28847726; rs6716505; rs13410993; rs11693714; rs35584797; rs34617636; rs34088413; rs12622871; rs10209457; rs5835685; rs5835687; rs917436; rs12104874; rs10933456; rs7564199; rs34660503; rs4402705; rs10183520; rs3046317; rs34398242; rs35486102; rs35194717; rs7605839; rs34212212; rs35697287; rs36024578; rs28874086; rs10206564; rs35076196; rs34323275; rs34892908; rs34631670; rs33934505; rs34193222; rs10183432; rs35202631; rs13415827; rs34454142; rs13412267; rs28599871; rs10460440; rs4588140; rs35076177; rs5835684; rs13416620; rs13416665; rs10175465; rs13427050; rs10183725; rs35468647; rs35140289; rs36053410; rs13413349; rs34442284; rs35633639; rs35460315; rs11323864; rs34935392; rs35591991; rs11413909; rs35312435; rs10167563; rs35417307; rs7589538; rs34648163; rs28833261; rs11693718; rs13012457; rs13389062; rs5835686; rs35104636; rs35977051; rs28829033; rs34706033; rs28807099; rs36109899; rs16842542; rs13418088; rs35517147; rs35055946; rs34680995; rs3038700; rs4402709; rs34589629; rs10175147; rs35389393; rs10186068; rs34157085; rs13427854; rs11395471; rs34853011; rs11416542; rs35914872; rs7596057; rs35868430; rs35112132; rs13395928; rs13019867; rs10208607; rs3046319; rs10617951; rs10185823; rs34270243; rs13019865; rs6759429; rs10563166; rs34853147; rs10672261; rs36004863; rs13011867; rs13404450; rs34807293; rs13384407; rs34506664; rs34692448; rs35597793; rs13027617; rs34095699; rs7577178; rs13000552; rs6705270; rs36044623; rs35688453; rs35587030; rs34181729; rs10207916; rs13395544; rs10591831; rs35951280; rs35509538; rs7371040; rs10171454; rs5835688; rs35311908; rs13387173; rs13411417; rs34804695; rs35155903; rs34608455; rs36027783; rs35346642; rs1158092; rs10164918; rs35690771; rs35475728; rs4664241; rs5835689; rs16842631; rs28592926; rs11461708; rs35086036; rs35927015; rs11329452; rs10182683; rs34366637; rs34301784; rs11313905; rs7568699; rs10211260; rs35312089; rs35894691; rs13001633; rs13426920; rs34012057; rs10211674; rs10189273; rs7561784; rs10178978; rs41472346; rs13418081; rs35824279; rs35351369; rs28660327; rs6705376; rs12478184; rs36062141; rs11426649; rs34432055; rs36024954; rs34281845; rs13001639; rs10174277; rs35407621; rs34516060; rs2286434; rs13024270; rs34045341; rs10625973; rs35684986; rs6705279; rs4300787; rs34293201; rs10164653; rs13426502; rs13391015; rs11399969; rs35471010; rs13019127; rs34989247; rs4664917; rs34946444; rs10933454; rs11676663; rs11685602; rs11892485; rs11901550; rs12467193; rs12475094; rs1263154; rs1269326; rs13006741; rs13401024; rs1357185; rs16842366; rs16842635; rs16842639; rs17603340; rs2007056; rs2108811; rs2190954; rs2190955; rs2215174; rs2215175; rs2685641; rs6437122; rs6714867; rs714190; rs717378; rs720159; rs731627; rs736671; rs7573998; rs7577248

# Metabolic_Enzyme_5_General_References:
12849978

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5315

# Metabolic_Enzyme_6_Name:
Thymidine kinase 2, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Mt-TK

# Metabolic_Enzyme_6_Gene_Name:
TK2

# Metabolic_Enzyme_6_Protein_Sequence:
>Thymidine kinase 2, mitochondrial precursor
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFF
SNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLD
RHTRPQVSSVRLMERSIHSAR
YIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL
IVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
AIHHLHEEWLIKGSLFPMAAPVLVIEA
DHHHMERMLELFEQNRDRILTPENRKHCP

# Metabolic_Enzyme_6_Number_of_Residues:
266

# Metabolic_Enzyme_6_Molecular_Weight:
31142

# Metabolic_Enzyme_6_Theoretical_pI:
8.58

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs

# Metabolic_Enzyme_6_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_6_GenBank_ID_Protein:
1905969

# Metabolic_Enzyme_6_SwissProt_ID:
KITM_HUMAN (O00142)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TK2

# Metabolic_Enzyme_6_Geneatlas_id:
TK2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11831

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>705 bp

ATGGGTGCGTTCTGCCAGCGTCCTAGCAGTGATAAAGAACAGGAAAAAGAGAAAAAATC
AGTGATCTGTG
TCGAGGGCAATATTGCAGGTGGGAAGACGACATGCCTGGAATTCTTCT
CCAACGCGACAGACGTCGAGGT
GTTAACGGAGCCTGTGTCCAAGTGGAGAAATGTCCGT
GGCCACAATCCTCTGGGCCTGATGTACCACGAT
GCCTCTCGCTGGGGTCTTACGCTACA
GACTTATGTGCAGCTCACCATGCTGGACAGGCATACTCGTCCTC
AGGTGTCATCTGTAC
GGTTGATGGAGAGGTCGATTCACAGCGCAAGATACATTTTTGTAGAAAACCTGTA
TAGA
AGTGGGAAGATGCCAGAAGTGGACTATGTAGTTCTGTCGGAATGGTTTGACTGGATCTTG
AGGAAC
ATGGACGTGTCTGTTGATTTGATAGTTTACCTTCGGACCAATCCTGAGACTTG
TTACCAGAGGTTAAAGA
AGAGATGCAGGGAAGAGGAGAAGGTCATTCCGCTGGAATACC
TGGAAGCAATTCACCATCTCCATGAGGA
GTGGCTCATCAAAGGCAGCCTTTTCCCCATG
GCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCACATG
GAGAGGATGTTAGAACTCTT
TGAACAAAATCGGGATCGAATATTAACTCCAGAGAATCGGAAGCATTGCC
CATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U77088

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_6_Locus:
16q22-q23.1

# Metabolic_Enzyme_6_SNPs:
rs3743716; rs3743715; rs880530; rs3743712; rs28171; rs755717; rs13334391; rs11859474; rs7191420; rs3826160; rs10492904; rs8064139; rs9930226; rs8044223; rs4783639; rs13331952; rs12448325; rs2241618; rs1366213; rs4783654; rs4783655; rs12445633; rs3826161; rs9932597; rs16956600; rs2288399; rs9924426; rs662089; rs2303776; rs9924955; rs37176; rs4783646; rs9924301; rs12102747; rs2241619; rs3743714; rs2241620; rs13331838; rs16956603; rs7196467; rs11865664; rs16956605; rs12447515; rs755716; rs9927697; rs7201934; rs37175; rs3743713; rs16956609; rs9934461; rs3743711; rs34931863; rs10454065; rs35138698; rs9930576; rs34946221; rs34364005; rs34974830; rs11378667; rs4441262; rs4783563; rs5817591; rs4783635; rs36122550; rs7191325; rs12928320; rs34922912; rs984375; rs5817593; rs4783643; rs4783628; rs34611947; rs35796755; rs397690; rs41377345; rs4783645; rs8047367; rs7189418; rs34482717; rs7498573; rs34207747; rs9673833; rs35291905; rs13339200; rs5817592; rs7201353; rs28626568; rs10709269; rs28667656; rs4783617; rs28454745; rs34214117; rs11643785; rs34613947; rs1346481; rs11383723; rs13338614; rs11334281; rs34906745; rs34484474; rs37177; rs35473118; rs384261; rs36049416; rs1108281; rs12444469; rs12449200; rs13333315; rs1428106; rs16956627; rs16956693; rs2002907; rs2232722; rs2232724; rs2232725; rs37178; rs3785086; rs3785087; rs3785088; rs4783659; rs7199632; rs725131; rs7498942; rs8054664; rs8058090; rs9796829; rs9933115

# Metabolic_Enzyme_6_General_References:
9079672; 9989599; 11687801; 12391347

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5805

# Metabolic_Enzyme_7_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_7_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_7_Gene_Name:
NP

# Metabolic_Enzyme_7_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32118

# Metabolic_Enzyme_7_Theoretical_pI:
6.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_7_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NP

# Metabolic_Enzyme_7_Geneatlas_id:
NP

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_7_PDB_ID:
1RT9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q13.1

# Metabolic_Enzyme_7_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_7_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5806

# Metabolic_Enzyme_8_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_8_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_8_Gene_Name:
ECGF1

# Metabolic_Enzyme_8_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_8_Number_of_Residues:
482

# Metabolic_Enzyme_8_Molecular_Weight:
49956

# Metabolic_Enzyme_8_Theoretical_pI:
5.19

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_8_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_8_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_8_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ECGF1

# Metabolic_Enzyme_8_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_8_PDB_ID:
1UOU

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_8_Locus:
22q13|22q13.33

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5316

# Metabolic_Enzyme_9_Name:
Thymidylate synthase

# Metabolic_Enzyme_9_Synonyms:
TS; TSase

# Metabolic_Enzyme_9_Gene_Name:
TYMS

# Metabolic_Enzyme_9_Protein_Sequence:
>Thymidylate synthase
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDE
FPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLD
SLGFSTREEGDLGPVYGFQWR
HFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRII
MCAWNPRDLPLMALPPCHALCQFYVVNSELSC
QLYQRSGDMGLGVPFNIASYALLTYMI
AHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLR
ILRKVEKIDDFKAEDF
QIEGYNPHPTIKMEMAV

# Metabolic_Enzyme_9_Number_of_Residues:
313

# Metabolic_Enzyme_9_Molecular_Weight:
35716

# Metabolic_Enzyme_9_Theoretical_pI:
7.00

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  5,10-methylenetetrahydrofolate-dependent methyltransferase activity
Function:  thymidylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
Process:  pyrimidine nucleoside monophosphate biosynthesis
Process:  pyrimidine deoxyribonucleoside monophosphate biosynthesis
Process:  dTMP biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_9_Pathway:
map00240  Pyrimidine metabolism;
 map00670  One carbon pool by folate

# Metabolic_Enzyme_9_Reaction:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00303:Thymidylat_synt

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.1.1.45

# Metabolic_Enzyme_9_GenBank_ID_Protein:
37479

# Metabolic_Enzyme_9_SwissProt_ID:
TYSY_HUMAN (P04818)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
TYMS

# Metabolic_Enzyme_9_Geneatlas_id:
TYMS

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12441

# Metabolic_Enzyme_9_PDB_ID:
1JUJ

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>942 bp

ATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCACAGGAGCG
GGACGCCGAGC
CGCGTCCGCCGCACGGGGAGCTGCAGTACCTGGGGCAGATCCAACACA
TCCTCCGCTGCGGCGTCAGGAA
GGACGACCGCACGGGCACCGGCACCCTGTCGGTATTC
GGCATGCAGGCGCGCTACAGCCTGAGAGATGAA
TTCCCTCTGCTGACAACCAAACGTGT
GTTCTGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGG
GATCCACAAATGCTA
AAGAGCTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATCCCGAGACTT
TTTG
GACAGCCTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGTTTATGGCTTCCAG
TGGAGG
CATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTCAGGACAGGGAGT
TGACCAACTGCAAAGAG
TGATTGACACCATCAAAACCAACCCTGACGACAGAAGAATCA
TCATGTGCGCTTGGAATCCAAGAGATCT
TCCTCTGATGGCGCTGCCTCCATGCCATGCC
CTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGC
CAGCTGTACCAGAGATCGGG
AGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCA
CGTACATGA
TTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATA
T
TTACCTGAATCACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAGACCTTTC
CCAAAGCTCAGG
ATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGAAGACTT
TCAGATTGAAGGGTACAATCCGC
ATCCAACTATTAAAATGGAAATGGCTGTTTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
X02308

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_9_Locus:
18p11.32

# Metabolic_Enzyme_9_SNPs:
rs3786362; rs16948421; rs699517; rs16948409; rs2790; rs2612098; rs2853740; rs2612100; rs1001761; rs2847149; rs2853532; rs2853536; rs2244500; rs2612099; rs2853543; rs11873890; rs1004474; rs2612096; rs1059394; rs16948305; rs9953447; rs2847609; rs2847150; rs1051527; rs8088781; rs2612095; rs1059393; rs3826626; rs15872; rs2853524; rs2853537; rs16948322; rs34795969; rs2847151; rs1970763; rs2853528; rs2853535; rs2606245; rs2853525; rs2853534; rs2847153; rs35143366; rs11876369; rs2853526; rs8094124; rs35069638; rs2925470; rs2015944; rs2853527; rs36005458; rs35517586; rs35449827; rs35710611; rs36080427; rs34502878; rs34007153; rs523998; rs11540152; rs596909; rs11540153; rs2847608; rs34543484; rs287599; rs571276; rs188267; rs1134333; rs2853531; rs11872109; rs172296; rs2853540; rs2853541; rs34118802; rs11875638; rs287600; rs2124616; rs2853530; rs11872105; rs35087169; rs9675762; rs1134338; rs12958458; rs11875614; rs2853739; rs35914751; rs287601; rs1894234; rs35626549; rs2853538; rs1894233; rs12962403; rs287602; rs1672564; rs1134335; rs35338895; rs2606244; rs8093444; rs2847610; rs35723992; rs207950; rs11878085; rs36009852; rs2853529; rs28503425; rs12326481; rs34581442; rs207949; rs571377; rs8084452; rs35623440; rs34941278; rs1672569; rs2606243; rs2606242; rs644072; rs2926562; rs2847611; rs11874511; rs11411741; rs11875662; rs10502289; rs10502290; rs1058151; rs1059384; rs11081251; rs11081266; rs11664283; rs11873007; rs11876755; rs11877806; rs12373391; rs12964837; rs2276115; rs2298581; rs2298582; rs2298583; rs2606241; rs2606246; rs2612092; rs2741182; rs2741183; rs2741184; rs2741186; rs2847173; rs2847324; rs2847326; rs2847607; rs2847612; rs2847620; rs2853533; rs2853741; rs2853742; rs3198762; rs34445332; rs35173059; rs3744962; rs3786355; rs3819101; rs3819102; rs495139; rs502396; rs539913; rs548203; rs579099; rs686819; rs7229142; rs7239738; rs8089075; rs8423; rs9948583; rs9966612

# Metabolic_Enzyme_9_General_References:
2987839; 2243092; 2532645; 3839505; 2656695; 8845352; 11329255; 11278511

# Metabolic_Enzyme_9_References:
11984070; 12853888; 12903197; 17150837

# Metabolic_Enzyme_10_ID:
7434

# Metabolic_Enzyme_10_Name:
Caspase-3 precursor

# Metabolic_Enzyme_10_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_10_Gene_Name:
CASP3

# Metabolic_Enzyme_10_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_10_Number_of_Residues:
277

# Metabolic_Enzyme_10_Molecular_Weight:
31608

# Metabolic_Enzyme_10_Theoretical_pI:
6.51

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_10_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_10_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
CASP3

# Metabolic_Enzyme_10_Geneatlas_id:
CASP3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_10_PDB_ID:
1CP3

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q34

# Metabolic_Enzyme_10_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_10_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_10_References:
15178742; 15819958; 16772436

End of HMDB00012

Beginning of HMDB00014
# Accession_No:
HMDB00014

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-02-01 13:45:39

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxycytidine

# Description:
One of the principal nucleosides of DNA composed of cytosine and deoxyribose. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. When N1 is linked to the C1 of deoxyribose, deoxynucleosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), deoxycytidine triphosphate (dCTP). CTP is the source of the cytidine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of the deoxycytidine in DNA (deoxyribonucleic acid).

# Synonyms:
1-(2-Deoxy-b-D-ribofuranosyl)cytosine; 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-Cytosine; 2'-Deoxycytidine; 2-deoxy-Cytidine; 4-Amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone; Cytosine deoxyribonucleoside; Cytosine deoxyriboside; Deoxyribose cytidine; Desoxycytidine; deoxy-Cytidine; 1-(2-Deoxy-beta-delta-ribofuranosyl)cytosine; 1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-Cytosine; 4-Amino-1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2(1H)-pyrimidinone; 1-(2-Deoxy-beta-D-ribofuranosyl)cytosine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone

# Chemical_IUPAC_Name:
4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one

# Chemical_Formula:
C9H13N3O4

# Chemical_Structure:
tbl_chemical:::HMDB00014_ZOOM.png:::119283127102832366

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00014_THUMB.png:::119283126899324538

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines; Nucleosides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; primary amine; primary aromatic amine; oxo(het)arene; urea; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Purine metabolism; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
227.09061

# Molecular_Weight_Avg:
227.21722

# Smiles_String_isomeric:
NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2

# Smiles_String_canonical:
NC1=NC(=O)N(C=C1)C2CC(O)C(CO)O2

# KEGG_Compound_ID:
C00881

# BioCyc_ID:
DEOXYCYTIDINE

# PubChem_CID:
13711

# PubChem_SID:
829250; 10317412; 12016225; 829248; 585295; 7886940; 157047; 8160334; 841405; 596443; 726441; 823291; 10317409; 4137

# OMIM_ID:
164050; 176270; 232700

# Metagene_ID:
Not Available

# BiGG_ID:
36280

# Wikipedia_ID:
Deoxycytidine

# METLIN_ID:
3367

# Ref_ID:
15203276; 15116424; Maley, F. et al., J. Biol. Chem., 1958, 233, 1538-1543, (5-diphosphate); Charubala, R. et al., Synthesis, 1984, 965-968, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl); Schaller, H. et al., J.A.C.S., 1963, 85, 3821-3827, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl); Benz, E. et al., J.O.C., 1965, 30, 3067-3071, (4N-benzoyl, 5'-tosyl, 3',4N-dibenzoyl, 4N,5'-dibenzoyl, 5'-tosyl 4N-benzoyl, 5'-trityl 3',4N-dibenzoyl); Hruska, F.E. et al., Can. J. Chem., 1974, 52, 497-508, (pmr); 6714272; Jones, A.J. et al., Proc. Natl. Acad. Sci. U.S.A., 1970, 65, 27-30, CA, 72, 96682j, (cmr); Miles, H.T., J.A.C.S., 1963, 85, 1007-1008, (ir, pmr); Young, D.W. et al., Acta Cryst. B, 1975, 31, 961-965, (cryst struct); 12171902; Michelson, A.M. et al., J.C.S., 1954, 34-40, (phosphates, 3',4N-di-Ac, 5'-trityl, 5'-trityl 3',4N-di-Ac); Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DAQ850; Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 396A, 396C, (nmr); Stawinski, J. et al., Chem. Comm., 1976, 243-244, (3',4N,5'-tribenzoyl); Ulbricht, T.L.V. et al., J.C.S., 1965, 6134-6135, (3N-Me); Wang, Z. et al., J.O.C., 2000, 65, 5969-5985, (synth, ir, pmr, cmr); Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138, (5'-triphosphate, synth, uv, biochem); Fox, J.J. et al., Adv. Carbohydr. Chem., 1959, 14, 283-380, (rev, derivs); Saladino, R. et al., Tetrahedron, 1996, 52, 6759-6780, (4N-Me, 4N-Et, 4N-(4-methylphenyl), synth, pmr, cmr); Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 832B, 838D, 839C, (ir); 3243806; Yang, J.T. et al., CA, 1966, 65, 12454, (ord)

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
951-77-9

# InChI:
InChI=1/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

# Synthesis_Reference:
Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138; Saneyoshi, M. et al., Nucleic Acids Res., 1981, 9, 3129-3138; Saladino, R. et al., Tetrahedron, 1996, 52, 6759-6780; Wang, Z. et al., J.O.C., 2000, 65, 5969-5985

# Melting_Point:
207-210 oC

# Melting_Point_predicted:
108.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
870 mg/mL [free base, HMP experimental]

# H2O_Solubility_Predicted:
63.4 mg/mL [MEYLAN,WM et al. (1996)]; 15.9 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.77 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.92 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00881.mol:::1132723801156107349

# SDF_File_[Text]:
tbl_chemical:::HMDB00014.sdf:::119283126433212682

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00014.pdb:::119283126726122733

# PDB_ID:
1J90

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1J90.txt:::1132720898718427316

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_presat.png:::11551555101945511

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_presat.zip:::115515551020999995

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041105_P00_04_HW_1DP_Assigned.png:::115628031058063658

# C_NMR_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94.jpg:::114168459446033390

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94.zip:::114168459443255687

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041105_P00_04_HW_1DC_94_Assigned.jpg:::115946433348387500

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339.jpg:::114608624892911228

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339.zip:::11460862490032504

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041105_P00_04_HW_2DHSQC_339_Assigned.jpg:::115946429593996119

# Predicted_H_NMR_Spectrum:
tbl_chemical:::2'-Deoxycytidine.gif:::1132732098828208828

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00014_peaks.txt:::1156309484160595268

# Predicted_C_NMR_Spectrum:
tbl_chemical:::2'-Deoxycytidine_C.gif:::1132737657297963376

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00014_peaks.txt:::1156310676184225629

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00014L.png:::117555261807188854; Medium Energy:tbl_ms:::HMDB00014M.png:::117555266921725073; High Energy:tbl_ms:::HMDB00014H.png:::117555270808365480

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.65 +/- 0.27	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Blood	< 0.5	uM	Adult:>18_yrs_old	Both	Normal	3243806


# Concentration_[Abnormal]:
Urine	0.27 +/- 0.193	umol/mmol_creatinine	Adult:>18_yrs_old	Both		15116424


# Associated_Disorders:
Not Available

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5235

# Metabolic_Enzyme_1_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_1_Synonyms:
dCK

# Metabolic_Enzyme_1_Gene_Name:
DCK

# Metabolic_Enzyme_1_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_1_Number_of_Residues:
260

# Metabolic_Enzyme_1_Molecular_Weight:
30519

# Metabolic_Enzyme_1_Theoretical_pI:
4.88

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_1_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DCK

# Metabolic_Enzyme_1_Geneatlas_id:
DCK

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_1_PDB_ID:
1P62

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_1_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_1_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_1_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5229

# Metabolic_Enzyme_2_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_2_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_2_Gene_Name:
NT5E

# Metabolic_Enzyme_2_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_2_Number_of_Residues:
574

# Metabolic_Enzyme_2_Molecular_Weight:
63368

# Metabolic_Enzyme_2_Theoretical_pI:
7.04

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_2_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_2_Signals:
1-26

# Metabolic_Enzyme_2_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_2_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
NT5E

# Metabolic_Enzyme_2_Geneatlas_id:
NT5E

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_2_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6q14-q21

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5315

# Metabolic_Enzyme_3_Name:
Thymidine kinase 2, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Mt-TK

# Metabolic_Enzyme_3_Gene_Name:
TK2

# Metabolic_Enzyme_3_Protein_Sequence:
>Thymidine kinase 2, mitochondrial precursor
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFF
SNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLD
RHTRPQVSSVRLMERSIHSAR
YIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL
IVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
AIHHLHEEWLIKGSLFPMAAPVLVIEA
DHHHMERMLELFEQNRDRILTPENRKHCP

# Metabolic_Enzyme_3_Number_of_Residues:
266

# Metabolic_Enzyme_3_Molecular_Weight:
31142

# Metabolic_Enzyme_3_Theoretical_pI:
8.58

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs

# Metabolic_Enzyme_3_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + thymidine = ADP + thymidine 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.7.1.21

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1905969

# Metabolic_Enzyme_3_SwissProt_ID:
KITM_HUMAN (O00142)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TK2

# Metabolic_Enzyme_3_Geneatlas_id:
TK2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11831

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>705 bp

ATGGGTGCGTTCTGCCAGCGTCCTAGCAGTGATAAAGAACAGGAAAAAGAGAAAAAATC
AGTGATCTGTG
TCGAGGGCAATATTGCAGGTGGGAAGACGACATGCCTGGAATTCTTCT
CCAACGCGACAGACGTCGAGGT
GTTAACGGAGCCTGTGTCCAAGTGGAGAAATGTCCGT
GGCCACAATCCTCTGGGCCTGATGTACCACGAT
GCCTCTCGCTGGGGTCTTACGCTACA
GACTTATGTGCAGCTCACCATGCTGGACAGGCATACTCGTCCTC
AGGTGTCATCTGTAC
GGTTGATGGAGAGGTCGATTCACAGCGCAAGATACATTTTTGTAGAAAACCTGTA
TAGA
AGTGGGAAGATGCCAGAAGTGGACTATGTAGTTCTGTCGGAATGGTTTGACTGGATCTTG
AGGAAC
ATGGACGTGTCTGTTGATTTGATAGTTTACCTTCGGACCAATCCTGAGACTTG
TTACCAGAGGTTAAAGA
AGAGATGCAGGGAAGAGGAGAAGGTCATTCCGCTGGAATACC
TGGAAGCAATTCACCATCTCCATGAGGA
GTGGCTCATCAAAGGCAGCCTTTTCCCCATG
GCAGCCCCTGTTCTGGTGATTGAGGCTGACCACCACATG
GAGAGGATGTTAGAACTCTT
TGAACAAAATCGGGATCGAATATTAACTCCAGAGAATCGGAAGCATTGCC
CATAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U77088

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_3_Locus:
16q22-q23.1

# Metabolic_Enzyme_3_SNPs:
rs3743716; rs3743715; rs880530; rs3743712; rs28171; rs755717; rs13334391; rs11859474; rs7191420; rs3826160; rs10492904; rs8064139; rs9930226; rs8044223; rs4783639; rs13331952; rs12448325; rs2241618; rs1366213; rs4783654; rs4783655; rs12445633; rs3826161; rs9932597; rs16956600; rs2288399; rs9924426; rs662089; rs2303776; rs9924955; rs37176; rs4783646; rs9924301; rs12102747; rs2241619; rs3743714; rs2241620; rs13331838; rs16956603; rs7196467; rs11865664; rs16956605; rs12447515; rs755716; rs9927697; rs7201934; rs37175; rs3743713; rs16956609; rs9934461; rs3743711; rs34931863; rs10454065; rs35138698; rs9930576; rs34946221; rs34364005; rs34974830; rs11378667; rs4441262; rs4783563; rs5817591; rs4783635; rs36122550; rs7191325; rs12928320; rs34922912; rs984375; rs5817593; rs4783643; rs4783628; rs34611947; rs35796755; rs397690; rs41377345; rs4783645; rs8047367; rs7189418; rs34482717; rs7498573; rs34207747; rs9673833; rs35291905; rs13339200; rs5817592; rs7201353; rs28626568; rs10709269; rs28667656; rs4783617; rs28454745; rs34214117; rs11643785; rs34613947; rs1346481; rs11383723; rs13338614; rs11334281; rs34906745; rs34484474; rs37177; rs35473118; rs384261; rs36049416; rs1108281; rs12444469; rs12449200; rs13333315; rs1428106; rs16956627; rs16956693; rs2002907; rs2232722; rs2232724; rs2232725; rs37178; rs3785086; rs3785087; rs3785088; rs4783659; rs7199632; rs725131; rs7498942; rs8054664; rs8058090; rs9796829; rs9933115

# Metabolic_Enzyme_3_General_References:
9079672; 9989599; 11687801; 12391347

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5802

# Metabolic_Enzyme_4_Name:
Cytidine deaminase

# Metabolic_Enzyme_4_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_4_Gene_Name:
CDA

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_4_Number_of_Residues:
146

# Metabolic_Enzyme_4_Molecular_Weight:
16185

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_4_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_4_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CDA

# Metabolic_Enzyme_4_Geneatlas_id:
CDA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_4_PDB_ID:
1MQ0

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_4_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p36.2-p35

# Metabolic_Enzyme_4_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_4_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5237

# Metabolic_Enzyme_5_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_5_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_5_Gene_Name:
NT5C2

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_5_Number_of_Residues:
561

# Metabolic_Enzyme_5_Molecular_Weight:
64970

# Metabolic_Enzyme_5_Theoretical_pI:
6.05

# Metabolic_Enzyme_5_GO_Classification:
Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_5_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5C2

# Metabolic_Enzyme_5_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_5_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_5_General_References:
7999131

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5807

# Metabolic_Enzyme_6_Name:
Protein disulfide-isomerase A4 precursor

# Metabolic_Enzyme_6_Synonyms:
Protein ERp-72; ERp72

# Metabolic_Enzyme_6_Gene_Name:
PDIA4

# Metabolic_Enzyme_6_Protein_Sequence:
>Protein disulfideisomerase A4 precursor
MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE
ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI
DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL
VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE
TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL
KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP
EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS
VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD
ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM
DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF
PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL

# Metabolic_Enzyme_6_Number_of_Residues:
645

# Metabolic_Enzyme_6_Molecular_Weight:
72933

# Metabolic_Enzyme_6_Theoretical_pI:
4.70

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  isomerase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_6_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the rearrangement of -S-S- bonds in proteins

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Catalyses the rearrangement of -S-S- bonds in proteins

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00085:Thioredoxin

# Metabolic_Enzyme_6_Signals:
1-20

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 5.3.4.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181508

# Metabolic_Enzyme_6_SwissProt_ID:
PDIA4_HUMAN (P13667)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PDIA4

# Metabolic_Enzyme_6_Geneatlas_id:
PDIA4

# Metabolic_Enzyme_6_hgnc_id:
HGNC:30167

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_6_Gene_Sequence:
>1938 bp
ATGAGGCCCCGGAAAGCCTTCCTGCTCCTGCTGCTCTTGGGGCTGGTGCAGCTGCTGGCC
GTGGCGGGTGCCGAGGGCCCGGACGAGGATTCTTCTAACAGAGAAAATGCCATTGAGGAT
GAAGAGGAGGAGGAGGAGGAAGATGATGATGAGGAAGAAGACGACTTGGAAGTTAAGGAA
GAAAATGGAGTCTTGGTCCTAAATGATGCAAACTTTGATAATTTTGTGGCTGACAAAGAC
ACAGTGCTGCTGGAGTTTTATGCTCCATGGTGTGGACATTGCAAGCAGTTTGCTCCGGAA
TATGAAAAAATTGCCAACATATTAAAGGATAAAGATCCTCCCATTCCTGTTGCCAAGATC
GATGCAACCTCAGCGTCTGTGCTGGCCAGCAGGTTTGATGTGAGTGGCTACCCCACCATC
AAGATCCTTAAGAAGGGGCAGGCTGTAGACTACGAGGGCTCCAGAACCCAGGAAGAAATT
GTTGCCAAGGTCAGAGAAGTCTCCCAGCCCGACTGGACGCCTCCACCAGAAGTCACGCTT
GTGTTGACCAAAGAGAACTTTGATGAAGTTGTGAATGATGCAGATATCATTCTGGTGGAG
TTTTATGCCCCATGGTGTGGACACTGCAAGAAACTTGCCCCCGAGTATGAGAAGGCCGCC
AAGGAGCTCAGCAAGCGTTCTCCTCCAATTCCCCTGGCAAAGGTCGACGCCACCGCAGAA
ACAGACCTGGCCAAGAGGTTTGATGTCTCTGGCTATCCCACCCTGAAAATTTTCCGCAAA
GGAAGGCCTTATGACTACAACGGCCCACGAGAAAAATATGGAATCGTTGATTACATGATC
GAGCAGTCCGGGCCTCCCTCCAAGGAGATTCTGACCCTGAAGCAGGTCCAGGAGTTCCTG
AAGGATGGAGACGATGTCATCATCATCGGGGTCTTTAAGGGGGAGAGTGACCCAGCCTAC
CAGCAATACCAGGATGCCGCTAACAACCTGAGAGAAGATTACAAATTTCACCACACTTTC
AGCACAGAAATAGCAAAGTTCTTGAAAGTCTCCCAGGGGCAGTTGGTTGTAATGCAGCCT
GAGAAATTCCAGTCCAAGTATGAGCCCCGGAGCCACATGATGGACGTCCAGGGCTCCACC
CAGGACTCGGCCATCAAGGACTTCGTGCTGAAGTACGCCCTGCCCCTGGTTGGCCACCGC
AAGGTGTCAAACGATGCTAAGCGCTACACCAGGCGCCCCCTGGTGGTCGTCTACTACAGT
GTGGACTTCAGCTTTGATTACAGAGCTGCAACTCAGTTTTGGCGGAGCAAAGTCCTAGAG
GTGGCCAAGGACTTCCCTGAGTACACCTTTGCCATTGCGGACGAAGAGGACTATGCTGGG
GAGGTGAAGGACCTGGGGCTCAGCGAGAGTGGGGAGGATGTCAATGCCGCCATCCTGGAC
GAGAGTGGGAAGAAGTTCGCCATGGAGCCAGAGGAGTTTGACTCTGACACCCTCCGCGAG
TTTGTCACTGCTTTCAAAAAAGGAAAACTGAAGCCAGTCATCAAATCCCAGCCAGTGCCC
AAGAACAACAAGGGACCCGTCAAGGTCGTGGTGGGAAAGACCTTTGACTCCATTGTGATG
GACCCCAAGAAGGACGTCCTCATCGAGTTCTACGCGCCATGGTGCGGGCACTGCAAGCAG
CTAGAGCCCGTGTACAACAGCCTGGCCAAGAAGTACAAGGGCCAAAAGGGCCTGGTCATC
GCCAAGATGGACGCCACTGCCAACGACGTCCCCAGCGACCGCTATAAGGTGGAGGGCTTC
CCCACCATCTACTTCGCCCCCAGTGGGGACAAAAAGAACCCAGTTAAATTTGAGGGTGGA
GACAGAGATCTGGAGCATTTGAGCAAGTTTATAGAAGAACATGCCACAAAACTGAGCAGG
ACCAAGGAAGAGCTTTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
J05016

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_6_Locus:
7q35

# Metabolic_Enzyme_6_SNPs:
rs2290971; rs35207074; rs1052549; rs9065; rs2306169; rs6969638; rs1382192; rs6464930; rs4727006; rs4727005; rs7795577; rs2306172; rs1382191; rs6464929; rs728451; rs4727009; rs11980538; rs12534095; rs2290970; rs6965276; rs1551927; rs7778448; rs6952916; rs7793916; rs4727007; rs718411; rs11976467; rs1962977; rs7777113; rs1020940; rs3779039; rs6978068; rs1551926; rs7787508; rs6464933; rs6948711; rs6977370; rs6963547; rs7808287; rs6944853; rs7781312; rs11974099; rs6965440; rs10085877; rs10272564; rs10269104; rs4727008; rs6947874; rs1962975; rs9918632; rs1962976; rs7455991; rs899129; rs6464928; rs6954405; rs10236640; rs11974627; rs6953222; rs6953180; rs10269506; rs11509175; rs17171156; rs7812195; rs10236808; rs11971515; rs2306170; rs7807788; rs11546292; rs6971353; rs1052626; rs11546290; rs35572261; rs11546289; rs13243678; rs1052599; rs6958855; rs10243245; rs35590396; rs6978647; rs13244008; rs5888347; rs11410607; rs28497061; rs28532077; rs3084442; rs3084443; rs34125437; rs34989074; rs10229806; rs4725794; rs35343205; rs10271571; rs10233535; rs35359302; rs12704057; rs13247593; rs41278746; rs34480442; rs10548888; rs2306171; rs28463009; rs6973873; rs35339835; rs12334067; rs10258441; rs6464934; rs13230041; rs41278749; rs12333828; rs4725795; rs34656815; rs35909633; rs11315544; rs10262716; rs35693482; rs13230031; rs10233906; rs35881176; rs35129885; rs35825784; rs11361769; rs10671079; rs35304005; rs35786243; rs35812027; rs34909003; rs3204774; rs11365856; rs6973217; rs10609306; rs11414114; rs28379751; rs11981448; rs10224999; rs10251886; rs12667507; rs4725793; rs716817; rs716818; rs7776474; rs7798153

# Metabolic_Enzyme_6_General_References:
2549034; 2002068

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5803

# Metabolic_Enzyme_7_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_7_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_7_Gene_Name:
AICDA

# Metabolic_Enzyme_7_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_7_Number_of_Residues:
198

# Metabolic_Enzyme_7_Molecular_Weight:
23954

# Metabolic_Enzyme_7_Theoretical_pI:
9.66

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_7_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_7_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_7_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
AICDA

# Metabolic_Enzyme_7_Geneatlas_id:
AICDA

# Metabolic_Enzyme_7_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_7_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_7_Locus:
12p13

# Metabolic_Enzyme_7_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_7_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
7643

# Metabolic_Enzyme_8_Name:
DNA

# Metabolic_Enzyme_8_Synonyms:
cytosine-5-methyltransferase 1; Dnmt1; DNA methyltransferase HsaI; DNA MTase HsaI; MCMT; M.HsaI

# Metabolic_Enzyme_8_Gene_Name:
DNMT1

# Metabolic_Enzyme_8_Protein_Sequence:
>
DNAMPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEI
KNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEA
RRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAK
RKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEER
DEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKR
RPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCG
QYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHG
HLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALI
GFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPP
SGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRA
QARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCE
VCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKK
MHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLA
RVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYK
APSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCA
RLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVK
RPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIR
VNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSM
GGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLP
KLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKL
VMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDY
YRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILA
AAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEV
RNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWR
DLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIP
WCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQ
GFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD

# Metabolic_Enzyme_8_Number_of_Residues:
1616

# Metabolic_Enzyme_8_Molecular_Weight:
183167

# Metabolic_Enzyme_8_Theoretical_pI:
7.81

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  protein binding
Function:  transcription factor binding
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA modification
Process:  DNA alkylation
Process:  DNA methylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Metabolic_Enzyme_8_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_8_Specific_Function:
Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2

# Metabolic_Enzyme_8_Pathway:
map00271  Methionine metabolism

# Metabolic_Enzyme_8_Reaction:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF01426:BAH;
PF06464:DMAP_binding;
PF00145:DNA_methylase;
PF02008:zf-CXXC

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.1.1.37

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1632819

# Metabolic_Enzyme_8_SwissProt_ID:
DNMT1_HUMAN (P26358)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DNMT1

# Metabolic_Enzyme_8_Geneatlas_id:
DNMT1

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2976

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_8_Gene_Sequence:
>4851 bp
ATGCCGGCGCGTACCGCCCCAGCCCGGGTGCCCACACTGGCCGTCCCGGCCATCTCGCTG
CCCGACGATGTCCGCAGGCGGCTCAAAGATTTGGAAAGAGACAGCTTAACAGAAAAGGAA
TGTGTGAAGGAGAAATTGAATCTCTTGCACGAATTTCTGCAAACAGAAATAAAGAATCAG
TTATGTGACTTGGAAACCAAATTACGTAAAGAAGAATTATCCGAGGAGGGCTACCTGGCT
AAAGTCAAATCCCTTTTAAATAAAGATTTGTCCTTGGAGAACGGTGCTCATGCTTACAAC
CGGGAAGTGAATGGACGTCTAGAAAACGGGAACCAAGCAAGAAGTGAAGCCCGTAGAGTG
GGAATGGCAGATGCCAACAGCCCCCCCAAACCCCTTTCCAAACCTCGCACGCCCAGGAGG
AGCAAGTCCGATGGAGAGGCTAAGCCTGAACCTTCACCTAGCCCCAGGATTACAAGGAAA
AGCACCAGGCAAACCACCATCACATCTCATTTTGCAAAGGGCCCTGCCAAACGGAAACCT
CAGGAAGAGTCTGAAAGAGCCAAATCGGATGAGTCCATCAAGGAAGAAGACAAAGACCAG
GATGAGAAGAGACGTAGAGTTACATCCAGAGAACGAGTTGCTAGACCGCTTCCTGCAGAA
GAACCTGAAAGAGCAAAATCAGGAACGCGCACTGAAAAGGAAGAAGAAAGAGATGAAAAA
GAAGAAAAGAGACTCCGAAGTCAAACCAAAGAACCAACACCCAAACAGAAACTGAAGGAG
GAGCCGGACAGAGAAGCCAGGGCAGGCGTGCAGGCTGACGAGGACGAAGATGGAGACGAG
AAAGATGAGAAGAAGCACAGAAGTCAACCCAAAGATCTAGCTGCCAAACGGAGGCCCGAA
GAAAAAGAACCTGAAAAAGTAAATCCACAGATTTCTGATGAAAAAGACGAGGATGAAAAG
GAGGAGAAGAGACGCAAAACGACCCCCAAAGAACCAACGGAGAAAAAAATGGCTCGCGCC
AAAACAGTCATGAACTCCAAGACCCACCCTCCCAAGTGCATTCAGTGCGGGCAGTACCTG
GACGACCCTGACCTCAAATATGGGCAGCACCCACCAGACGCGGTGGATGAGCCACAGATG
CTGACAAATGAGAAGCTGTCCATCTTTGATGCCAACGAGTCTGGCTTTGAGAGTTATGAG
GCGCTTCCCCAGCACAAACTGACCTGCTTCAGTGTGTACTGTAAGCACGGTCACCTGTGT
CCCATCGACACCGGCCTCATCGAGAAGAATATCGAACTCTTCTTTTCTGGTTCAGCAAAA
CCAATCTATGATGATGACCCGTCTCTTGAAGGTGGTGTTAATGGCAAAAATCTTGGCCCC
ATAAATGAATGGTGGATCACTGGCTTTGATGGAGGTGAAAAGGCCCTCATCGGCTTCAGC
ACCTCATTTGCCGAATACATTCTGATGGATCCCAGTCCCGAGTATGCGCCCATATTTGGG
CTGATGCAGGAGAAGATCTACATCAGCAAGATTGTGGTGGAGTTCCTGCAGAGCAATTCC
GACTCGACCTATGAGGACCTGATCAACAAGATCGAGACCACGGTTCCTCCTTCTGGCCTC
AACTTGAACCGCTTCACAGAGGACTCCCTCCTGCGACACGCGCAGTTTGTGGTGGAGCAG
GTGGAGAGTTATGACGAGGCCGGGGACAGTGATGAGCAGCCCATCTTCCTGACGCCCTGC
ATGCGGGACCTGATCAAGCTGGCTGGGGTCACGCTGGGACAGAGGCGAGCCCAGGCGAGG
CGGCAGACCATCAGGCATTCTACCAGGGAGAAGGACAGGGGACCCACGAAAGCCACCACC
ACCAAGCTGGTCTACCAGATCTTCGATACTTTCTTCGCAGAGCAAATTGAAAAGGATGAC
AGAGAAGACAAGGAGAACGCCTTTAAGCGCCGGCGATGTGGCGTCTGTGAGGTGTGTCAG
CAGCCTGAGTGTGGGAAATGTAAAGCCTGCAAGGACATGGTTAAATTTGGTGGCAGTGGA
CGGAGCAAGCAGGCTTGCCAAGAGCGGAGGTGTCCCAATATGGCCATGAAGGAGGCAGAT
GACGATGAGGAAGTCGATGATAACATCCCAGAGATGCCGTCACCCAAAAAAATGCACCAG
GGGAAGAAGAAGAAACAGAACAAGAATCGCATCTCTTGGGTCGGAGAAGCCGTCAAGACT
GATGGGAAGAAGAGTTACTATAAGAAGGTGTGCATTGATGCGGAAACCCTGGAAGTGGGG
GACTGTGTCTCTGTTATTCCAGATGATTCCTCAAAACCGCTGTATCTAGCAAGGGTCACG
GCGCTGTGGGAGGACAGCAGCAACGGGCAGATGTTTCACGCCCACTGGTTCTGCGCTGGG
ACAGACACAGTCCTCGGGGCCACGTCGGACCCTCTGGAGCTGTTCTTGGTGGATGAATGT
GAGGACATGCAGCTTTCATATATCCACAGCAAAGTGAAAGTCATCTACAAAGCCCCCTCC
GAAAACTGGGCCATGGAGGGAGGCATGGATCCCGAGTCCCTGCTGGAGGGGGACGACGGG
AAGACCTACTTCTACCAGCTGTGGTATGATCAAGACTACGCGAGATTCGAGTCCCCTCCA
AAAACCCAGCCAACAGAGGACAACAAGTTCAAATTCTGTGTGAGCTGTGCCCGTCTGGCT
GAGATGAGGCAAAAAGAAATCCCCAGGGTCCTGGAGCAGCTCGAGGACCTGGATAGCCGG
GTCCTCTACTACTCAGCCACCAAGAACGGCATCCTGTACCGAGTTGGTGATGGTGTGTAC
CTGCCCCCTGAGGCCTTCACGTTCAACATCAAGCTGTCCAGTCCCGTGAAACGCCCACGG
AAGGAGCCCGTGGATGAGGACCTGTACCCAGAGCACTACCGGAAATACTCCGACTACATC
AAAGGCAGCAACCTGGATGCCCCTGAGCCCTACCGAATTGGCCGGATCAAAGAGATCTTC
TGTCCCAAGAAGAGCAACGGCAGGCCCAATGAGACTGACATCAAAATCCGGGTCAACAAG
TTCTACAGGCCTGAGAACACCCACAAGTCCACTCCAGCGAGCTACCACGCAGACATCAAC
CTGCTCTACTGGAGCGACGAGGAGGCCGTGGTGGACTTCAAGGCTGTGCAGGGCCGCTGC
ACCGTGGAGTATGGGGAGGACCTGCCCGAGTGCGTCCAGGTGTACTCCATGGGCGGCCCC
AACCGCTTCTACTTCCTCGAGGCCTATAATGCAAAGAGCAAAAGCTTTGAAGATCCTCCC
AACCATGCCCGTAGCCCTGGAAACAAAGGGAAGGGCAAGGGAAAAGGGAAGGGCAAGCCC
AAGTCCCAAGCCTGTGAGCCGAGCGAGCCAGAGATAGAGATCAAGCTGCCCAAGCTGCGG
ACCCTGGATGTGTTTTCTGGCTGCGGGGGGTTGTCGGAGGGATTCCACCAAGCAGGCATC
TCTGACACGCTGTGGGCCATCGAGATGTGGGACCCTGCGGCCCAGGCGTTCCGGCTGAAC
AACCCCGGCTCCACAGTGTTCACAGAGGACTGCAACATCCTGCTGAAGCTGGTCATGGCT
GGGGAGACCACCAACTCCCGCGGCCAGCGGCTGCCCCAGAAGGGAGACGTGGAGATGCTG
TGCGGCGGGCCGCCCTGCCAGGGCTTCAGCGGCATGAACCGCTTCAATTCGCGCACCTAC
TCCAAGTTCAAAAACTCTCTGGTGGTTTCCTTCCTCAGCTACTGCGACTACTACCGGCCC
CGGTTCTTCCTCCTGGAGAATGTCAGGAACTTTGTCTCCTTCAAGCGCTCCATGGTCCTG
AAGCTCACCCTCCGCTGCCTGGTCCGCATGGGCTATCAGTGCACCTTCGGCGTGCTGCAG
GCCGGTCAGTACGGCGTGGCCCAGACTAGGAGGCGGGCCATCATCCTGGCCGCGGCCCCT
GGAGAGAAGCTCCCTCTGTTCCCGGAGCCACTGCACGTGTTTGCTCCCCGGGCCTGCCAG
CTGAGCGTGGTGGTGGATGACAAGAAGTTTGTGAGCAACATAACCAGGTTGAGCTCGGGT
CCTTTCCGGACCATCACGGTGCGAGACACGATGTCCGACCTGCCGGAGGTGCGGAATGGA
GCCTCGGCACTGGAGATCTCCTACAACGGGGAGCCTCAGTCCTGGTTCCAGAGGCAGCTC
CGGGGCGCACAGTACCAGCCCATCCTCAGGGACCACATCTGTAAGGACATGAGTGCATTG
GTGGCTGCCCGCATGCGGCACATCCCCTTGGCCCCAGGGTCAGACTGGCGCGATCTGCCC
AACATCGAGGTGCGGCTCTCAGACGGCACCATGGCCAGGAAGCTGCGGTATACCCACCAT
GACAGGAAGAACGGCCGCAGCAGCTCTGGGGCCCTCCGTGGGGTCTGCTCCTGCGTGGAA
GCCGGCAAAGCCTGCGACCCCGCAGCCAGGCAGTTCAACACCCTCATCCCCTGGTGCCTG
CCCCACACCGGGAACCGGCACAACCACTGGGCTGGCCTCTATGGAAGGCTCGAGTGGGAC
GGCTTCTTCAGCACAACCGTCACCAACCCCGAGCCCATGGGCAAGCAGGGCCGCGTGCTC
CACCCAGAGCAGCACCGTGTGGTGAGCGTGCGGGAGTGTGCCCGCTCCCAGGGCTTCCCT
GACACCTACCGGCTCTTCGGCAACATCCTGGACAAGCACCGGCAGGTGGGCAATGCCGTG
CCACCGCCCCTGGCCAAAGCCATTGGCTTGGAGATCAAGCTTTGTATGTTGGCCAAAGCC
CGAGAGAGTGCCTCAGCTAAAATAAAGGAGGAGGAAGCTGCTAAGGACTAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X63692

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_8_Locus:
19p13.2

# Metabolic_Enzyme_8_SNPs:
rs8111085; rs16999593; rs2228613; rs2228611; rs721186; rs16999358; rs2162560; rs2241531; rs759920; rs4804124; rs2114724; rs8112801; rs10420321; rs8101626; rs6511685; rs2290684; rs9305012; rs2288350; rs2336691; rs4804489; rs4804490; rs7253378; rs10421746; rs4804494; rs2011034; rs10418707; rs10854076; rs12611113; rs11880553; rs6511677; rs2162559; rs7257298; rs10426223; rs11672909; rs2288349; rs7253062; rs4804125; rs6511570; rs10416200; rs8111808; rs7258766; rs10413185; rs10407514; rs2336690; rs6511611; rs7247491; rs11879603; rs6511678; rs6511610; rs12609071; rs10422286; rs8108925; rs8101866; rs10405735; rs11880388; rs12611271; rs10423673; rs12609152; rs11881310; rs12460767; rs4804493; rs10423341; rs1863771; rs8112895; rs10426062; rs11670357; rs10408180; rs10414661; rs35622143; rs2229858; rs9676676; rs13784; rs11488; rs35641518; rs4804492; rs12971774; rs10405146; rs28501615; rs17333908; rs5827090; rs28787955; rs3745271; rs34858632; rs11668641; rs35863536; rs4804491; rs36048626; rs3079975; rs6511612; rs3745270; rs35281765; rs11670667; rs34178852; rs34288732; rs11670269; rs35697879; rs12975631; rs36026709; rs7259561; rs10412016; rs33916380; rs34258350; rs11882187; rs36061584; rs35472577; rs7253898; rs11671475; rs35583463; rs34374135; rs35918857; rs35841466; rs919188; rs34352285; rs10422231; rs35310173; rs35795837; rs5827091; rs11670665; rs34173597; rs34559337; rs34387000; rs34081018; rs5827089; rs34539107; rs35217527; rs10425105; rs28607407; rs35693490; rs34495234; rs34918104; rs35744087; rs10412529; rs8104968; rs10413872; rs28493477; rs5827088; rs3217302; rs35012154; rs11672866; rs34369468; rs2290683; rs34993621; rs34705022; rs34225538; rs34252933; rs34930749; rs35238334; rs8102368; rs35336927; rs34698448; rs3079962; rs11880117; rs34719680; rs34784157; rs3079979; rs34064945; rs10422860; rs35721499; rs35245682; rs35635942; rs35490778; rs12979227; rs8103303; rs11666205; rs36001002; rs4804126; rs3745269; rs3214543; rs28398225; rs10404658; rs10407697; rs3079977; rs28706753; rs28679320; rs7248120; rs35454711; rs35029521; rs34268510; rs12984523; rs34911732; rs35600922; rs10403947; rs10416722; rs12462004; rs2116940

# Metabolic_Enzyme_8_General_References:
1594447; 8940105; 10449766; 10753866; 9302295; 10947852; 10888872; 10888886; 10325416

# Metabolic_Enzyme_8_References:
15534852; 15746193; 15899874; 16219133

# Metabolic_Enzyme_9_ID:
8666

# Metabolic_Enzyme_9_Name:
Hypothetical protein NT5C1B

# Metabolic_Enzyme_9_Synonyms:
Not Available

# Metabolic_Enzyme_9_Gene_Name:
NT5C1B

# Metabolic_Enzyme_9_Protein_Sequence:
>Hypothetical protein NT5C1
BMQENPEAWAQGIVREIRQTRDSQPLEYSRTSPTEWKSSSQRRGIYPASTQLDRNSLSEQ
QQQQREDEDDYEAAYWASMRSFYEKNPSCSRPWPPKPKNAITIALSSCALFNMVDGRKIY
EQEGLEKYMEYQLTNENVILTPGPAFRFVKALQYVNARLRDLYPDEQDLFDIVLMTNNHA
QVGVRLINSVNHYGLLIDRFCLTGGKDPIGYLKAYLTNLYIAADSEKVQEAIQEGIASAT
MFDGAKDMAYCDTQLRVAFDGDAVLFSDESEHFTKEHGLDKFFQYDTLCESKPLAQGPLK
GFLEDLGRLQKKFYAKNERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAG
APKSPILVKIRPHIFFDDHMFHIEGAQRLGSIAAYGFNKKFSS

# Metabolic_Enzyme_9_Number_of_Residues:
402

# Metabolic_Enzyme_9_Molecular_Weight:
45860

# Metabolic_Enzyme_9_Theoretical_pI:
6.41

# Metabolic_Enzyme_9_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
 Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Not Available

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_9_Signals:
Not Available

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
62702336

# Metabolic_Enzyme_9_SwissProt_ID:
Q53RX2_HUMAN (Q53RX2)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NT5C1B

# Metabolic_Enzyme_9_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>1209 bp
ATGCAAGAGAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCGCCAGACCCGG
GACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTCCTCCAGCCAG
CGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTCCGAGCAGCAG
CAGCAGCAGCGGGAGGACGAGGACGACTACGAGGCTGCCTACTGGGCATCCATGAGGTCG
TTCTACGAGAAGAACCCGAGCTGCTCGCGCCCCTGGCCGCCCAAACCCAAGAACGCCATC
ACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAAAATCTACGAG
CAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGTCATCCTGACC
CCGGGCCCGGCGTTCCGCTTCGTCAAGGCACTACAGTATGTCAATGCTAGACTCCGTGAT
CTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAACCATGCCCAA
GTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGACCGCTTCTGT
CTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAACTTGTATATT
GCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTCTGCGACAATG
TTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGCCTTTGATGGG
GATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGGGCTCGACAAA
TTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCCCCTAAAAGGC
TTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGAACGGTTACTT
TGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGGCGCCCGTGTG
CTGAAGACCCTTCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCTTGCTGGAGCC
CCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGACCACATGTTC
CACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAATAAAAAATTC
AGTAGTTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AC079148

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p24.2

# Metabolic_Enzyme_9_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_9_General_References:
Not Available

# Metabolic_Enzyme_9_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7663

# Macromolecular_Interacting_Partner_1_Name:
Signal transducer and activator of transcription 3

# Macromolecular_Interacting_Partner_1_Synonyms:
Acute-phase response factor

# Macromolecular_Interacting_Partner_1_Gene_Name:
STAT3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Signal transducer and activator of transcription 3
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
770

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
88069

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.23

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00017:SH2;
PF01017:STAT_alpha;
PF02864:STAT_bind;
PF02865:STAT_int

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
475789

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
STAT3_HUMAN (P40763)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
STAT3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
STAT3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11364

# Macromolecular_Interacting_Partner_1_PDB_ID:
1BG1

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2313 bp
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCACCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGGATCGTGGAGCTGTTCAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAGTTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGTCTCAAGATTGACCTAGAGACCCACTCCTTGTCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTGAACTTCTTCACTAAGCCGCCAATTGGAACC
TGGGACCAAGTGGCCGAGGTGCTCAGCTGGCAGTTCTCGTCCACCACCAAGCGGGGGCTG
AGCATCGAGCAGCTGACAACGCTGGCTGAGAAGCTCCTAGGGCCTGGTGTGAACTACTCA
GGGTGTCAGATCACATGGGCTAACTTCTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TACTGGGTCTGGCTAGACAATATCATCGACCTTGTGAAAAAGTATATCTTGGCCCTTTGG
AATGAAGGGTACATCATGGGTTTCATCAGCAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCCCCAGGCACCTTCCTGCTGCGCTTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGTTGTCTCCACTTGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGGAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGT
AGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAAT
ACCATTGACCTGCCGATGTCCCCCCGCGCTTTAGATTCATTGATGCAGTTTGGAAATAAT
GGTGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAG
TTGACCTCGGAGTGCGCTACCTCCCCCATGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
L29277

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_1_Locus:
17q21.31

# Macromolecular_Interacting_Partner_1_SNPs:
rs1064116; rs17882069; rs17880940; rs1064113; rs1905340; rs957970; rs1053005; rs744166; rs957971; rs1053004; rs1026916; rs4796792; rs9912773; rs1053023; rs8073836; rs6503697; rs4796791; rs9891119; rs12949918; rs8068748; rs9891867; rs7224416; rs11079042; rs7219059; rs4287619; rs3785898; rs16967719; rs8074288; rs8073517; rs1905341; rs13342031; rs7219739; rs17882369; rs7224007; rs7211777; rs4103200; rs12602466; rs3744483; rs3883338; rs9913597; rs11867382; rs8070763; rs17881668; rs17879497; rs12602449; rs7216516; rs17878746; rs17881438; rs7211264; rs6503698; rs9303328; rs9895473; rs17887094; rs17881805; rs17881664; rs8071537; rs17884307; rs17885629; rs12937642; rs8076051; rs17884090; rs17879207; rs17883506; rs12942547; rs17882436; rs12947808; rs7214610; rs1963988; rs17884541; rs8066517; rs17593222; rs17883029; rs3736164; rs11869886; rs4796646; rs17885278; rs9898794; rs1963987; rs2306580; rs8072566; rs6503696; rs2306581; rs9898884; rs8072391; rs2293152; rs9889396; rs3809758; rs7206960; rs9890635; rs8069645; rs8081431; rs7214964; rs7215104; rs8066464; rs9909659; rs8075442; rs6503695; rs9915916; rs9896889; rs7216201; rs7501954; rs8081037; rs7206950; rs8064496; rs10153241; rs8074524; rs9890802; rs3816769; rs3869550; rs17881940; rs3736161; rs12721576; rs7217655; rs3869549; rs7213632; rs16967689; rs4265875; rs7220550; rs17880900; rs17881621; rs12601611; rs7224339; rs7213633; rs12721583; rs17882163; rs17887066; rs17885291; rs7215694; rs8078731; rs2291281; rs17879752; rs17878412; rs17879738; rs17881759; rs17884478; rs1222187; rs17880538; rs17880983; rs17886724; rs17885350; rs17878930; rs17879287; rs17878696; rs17882516; rs17879962; rs8080551; rs11870967; rs17885431; rs17882334; rs17878674; rs17887068; rs17884929; rs17885741; rs12103893; rs2291282; rs17886496; rs17880347; rs3736162; rs17881032; rs17879513; rs17882035; rs17886256; rs17882406; rs17881320; rs17879198; rs17881938; rs8069836; rs17879459; rs4796793; rs16967725; rs17405722; rs17885036; rs17884075; rs909056; rs17880962; rs17878478; rs1141129; rs11547455; rs1064110; rs1803125; rs34460718; rs1064122; rs1064111; rs1064117; rs1141145; rs1141118; rs1064115; rs1141121; rs1141122; rs1141119; rs1064121; rs1064118; rs1064112; rs1141120; rs1064114; rs1141117; rs1141123; rs1064119; rs1064120; rs1141131; rs1141144; rs1141111; rs35342182; rs1222186; rs4796644; rs8075676; rs12938189; rs17883843; rs17881974; rs34393906; rs11449147; rs34788284; rs35901220; rs11408644; rs10659012; rs34354144; rs12938193; rs1803126; rs11871210; rs34115235; rs34263131; rs12953155; rs34094936; rs7211035; rs17880712; rs34972443; rs9897389; rs41289087; rs3736163; rs12946759; rs7214139; rs34003618; rs12938463; rs12951192; rs12936225; rs7207492; rs11408645; rs35729990; rs11408950; rs16967716; rs35427318; rs12951971; rs11457025; rs35840966; rs10775; rs7350890; rs12949179; rs17883295; rs35585589; rs8064997; rs34479652; rs4519378; rs12942611; rs11328125; rs35561964; rs1231903; rs35314169; rs8071969; rs1236315; rs35987545; rs17883814; rs12952630; rs35896270; rs11378560; rs12603457; rs12325774; rs17886670; rs3169702; rs34291674; rs12946874; rs35857074; rs7221074; rs11379691; rs11440924; rs35099574; rs12938461; rs11444177; rs12452182; rs11398324; rs11339093; rs10706301; rs17884918; rs34559610; rs12945333; rs8069115; rs17881859; rs17880808; rs34054293; rs35398041; rs35950888; rs17884714; rs34923201; rs17879250; rs17879442; rs35184581; rs34165663; rs11657309; rs17880904; rs17879681; rs8066904; rs17884716; rs17880663; rs35863777; rs17878909; rs1312364; rs34846688; rs11656164; rs9909736; rs12950549; rs17883005; rs17886263; rs17885843; rs8077296; rs8081156; rs7221636; rs34330322; rs17882635; rs36055143; rs12946502; rs8064327; rs35159711; rs17882551; rs35455295; rs11318541; rs11285572; rs35499754; rs10706259; rs17884756; rs17879448; rs3830585; rs8072736; rs35162488; rs17878464; rs17879201; rs12943176; rs17884004; rs35432758; rs10657713; rs11392125; rs35885311; rs744284; rs17882079; rs33997807; rs35332755; rs1057935; rs11079043; rs1135669; rs1135670; rs11658772; rs12601982; rs16967738; rs17320971; rs2067694; rs2272087; rs2293154; rs2293155; rs3198502; rs4621023; rs9889942; rs9906989; rs9915299

# Macromolecular_Interacting_Partner_1_General_References:
7512451; 9630560; 7701321; 12208879; 12023369

# Macromolecular_Interacting_Partner_1_References:
15354212; 16871283

# Macromolecular_Interacting_Partner_2_ID:
7816

# Macromolecular_Interacting_Partner_2_Name:
Histone deacetylase 1

# Macromolecular_Interacting_Partner_2_Synonyms:
HD1

# Macromolecular_Interacting_Partner_2_Gene_Name:
HDAC1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Histone deacetylase 1
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
482

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
55104

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  histone deacetylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid deacetylation
Process:  histone deacetylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_2_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1277084

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
HDAC1_HUMAN (Q13547)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
HDAC1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
HDAC1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:4852

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1449 bp
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA
AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT
TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT
CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT
CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT
GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC
CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC
CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT
GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG
TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG
TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT
TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG
TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA
CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC
GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG
GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT
TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG
AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA
ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC
CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC
TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC
AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC
GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG
TTGGCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U50079

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1p34

# Macromolecular_Interacting_Partner_2_SNPs:
rs8176782; rs6697130; rs7543692; rs16834954; rs16834956; rs16834958; rs16834963; rs16834957; rs12133048; rs17507358; rs12096858; rs17255809; rs690334; rs2127246; rs10914548; rs1741981; rs1140658; rs1140673; rs11541185; rs11541183; rs11541184; rs1140660; rs8176783; rs10914552; rs690332; rs35808493; rs12026405; rs552686; rs7533676; rs6679175; rs34899445; rs7512341; rs10914547; rs10914551; rs12723325; rs552733; rs34315355; rs34267128; rs12758327; rs10914546; rs12734422; rs34371852; rs10652556; rs34065217; rs10465520; rs690520; rs35894142; rs28419695; rs471372; rs35770915; rs34386633; rs552732; rs34447178; rs12727854; rs35678923; rs34021057; rs34742550; rs28372816; rs11589444; rs35790615; rs10465522; rs12022567; rs690006; rs690525; rs2019923; rs34403317; rs7544100; rs9699564; rs35191653; rs35577659; rs35345816; rs10465521; rs34304672; rs36212114; rs11459069; rs36212119; rs36212122; rs36211753; rs35299850; rs36212118; rs36212115; rs36212123; rs36212121; rs36212117; rs12090734; rs36212116; rs34992032; rs35764672; rs1042546; rs10914545; rs11576036; rs11576040; rs11576043; rs11807976; rs11809371; rs12048924; rs8176768; rs8176777; rs8176781

# Macromolecular_Interacting_Partner_2_General_References:
8602529; 8646880; 10487760; 10898795; 10669754; 11602581; 11331609; 11102443; 11427533; 12032081; 12670868; 12493763; 12482978; 12724404; 10904264

# Macromolecular_Interacting_Partner_2_References:
15746193; 16043219; 16464847

# Macromolecular_Interacting_Partner_3_ID:
8368

# Macromolecular_Interacting_Partner_3_Name:
DNA

# Macromolecular_Interacting_Partner_3_Synonyms:
cytosine-5-methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNMT3B

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>
DNAMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSK
REVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERH
RPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDT
HGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFS
WWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVS
YRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVV
NKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSR
EQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSY
CTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLR
RRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIK
VGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNV
NPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECN
PVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTK
SNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVP
VIRHLFAPLKDYFACE

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
853

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
95752

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.52

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA modification
Process:  DNA alkylation
Process:  DNA methylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs

# Macromolecular_Interacting_Partner_3_Pathway:
map00271  Methionine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00145:DNA_methylase;
PF00855:PWWP

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 2.1.1.37

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5823166

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DNM3B_HUMAN (Q9UBC3)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNMT3B

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNMT3B

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2979

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2313 bp
ATGAAGGGAGACACCAGGCATCTCAATGGAGAGGAGGACGCCGGCGGGAGGGAAGACTCG
ATCCTCGTCAACGGGGCCTGCAGCGACCAGTCCTCCGACTCGCCCCCAATCCTGGAGGCT
ATCCGCACCCCGGAGATCAGAGGCCGAAGATCAAGCTCGCGACTCTCCAAGAGGGAGGTG
TCCAGTCTGCTAAGCTACACACAGGACTTGACAGGCGATGGCGACGGGGAAGATGGGGAT
GGCTCTGACACCCCAGTCATGCCAAAGCTCTTCCGGGAAACCAGGACTCGTTCAGAAAGC
CCAGCTGTCCGAACTCGAAATAACAACAGTGTCTCCAGCCGGGAGAGGCACAGGCCTTCC
CCACGTTCCACCCGAGGCCGGCAGGGCCGCAACCATGTGGACGAGTCCCCCGTGGAGTTC
CCGGCTACCAGGTCCCTGAGACGGCGGGCAACAGCATCGGCAGGAACGCCATGGCCGTCC
CCTCCCAGCTCTTACCTTACCATCGACCTCACAGACGACACAGAGGACACACATGGGACG
CCCCAGAGCAGCAGTACCCCCTACGCCCGCCTAGCCCAGGACAGCCAGCAGGGGGGCATG
GAGTCCCCGCAGGTGGAGGCAGACAGTGGAGATGGAGACAGTTCAGAGTATCAGGATGGG
AAGGAGTTTGGAATAGGGGACCTCGTGTGGGGAAAGATCAAGGGCTTCTCCTGGTGGCCC
GCCATGGTGGTGTCTTGGAAGGCCACCTCCAAGCGACAGGCTATGTCTGGCATGCGGTGG
GTCCAGTGGTTTGGCGATGGCAAGTTCTCCGAGGTCTCTGCAGACAAACTGGTGGCACTG
GGGCTGTTCAGCCAGCACTTTAATTTGGCCACCTTCAATAAGCTCGTCTCCTATCGAAAA
GCCATGTACCATGCTCTGGAGAAAGCTAGGGTGCGAGCTGGCAAGACCTTCCCCAGCAGC
CCTGGAGACTCATTGGAGGACCAGCTGAAGCCCATGTTGGAGTGGGCCCACGGGGGCTTC
AAGCCCACTGGGATCGAGGGCCTCAAACCCAACAACACGCAACCAGAGAACAAGACTCGA
AGACGCACAGCTGACGACTCAGCCACCTCTGACTACTGCCCCGCACCCAAGCGCCTCAAG
ACAAATTGCTATAACAACGGCAAAGACCGAGGGGATGAAGATCAGAGCCGAGAACAAATG
GCTTCAGATGTTGCCAACAACAAGAGCAGCCTGGAAGATGGCTGTTTGTCTTGTGGCAGG
AAAAACCCCGTGTCCTTCCACCCTCTCTTTGAGGGGGGGCTCTGTCAGACATGCCGGGAT
CGCTTCCTTGAGCTGTTTTACATGTATGATGACGATGGCTATCAGTCTTACTGCACTGTG
TGCTGCGAGGGCCGAGAGCTGCTGCTTTGCAGCAACACGAGCTGCTGCCGGTGTTTCTGT
GTGGAGTGCCTGGAGGTGCTGGTGGGCACAGGCACAGCGGCCGAGGCCAAGCTTCAGGAG
CCCTGGAGCTGCTACATGTGTCTCCCGCAGCGCTGTCATGGCGTCCTGCGGCGCCGGAAG
GACTGGAACGTGCGCCTGCAGGCCTTCTTCACCAGTGACACGGGGCTTGAATACGAAGCC
CCCAAGCTGTACCCTGCCATTCCCGCAGCCCGAAGGCGGCCCATTCGAGTCCTGTCATTG
TTTGATGGCATCGCGACAGGCTACCTAGTCCTCAAAGAGTTGGGCATAAAGGTAGGAAAG
TACGTCGCTTCTGAAGTGTGTGAGGAGTCCATTGCTGTTGGAACCGTGAAGCACGAGGGG
AATATCAAATACGTGAACGACGTGAGGAACATCACAAAGAAAAATATTGAAGAATGGGGC
CCATTTGACTTGGTGATTGGCGGAAGCCCATGCAACGATCTCTCAAATGTGAATCCAGCC
AGGAAAGGCCTGTATGAGGGTACAGGCCGGCTCTTCTTCGAATTTTACCACCTGCTGAAT
TACTCACGCCCCAAGGAGGGTGATGACCGGCCGTTCTTCTGGATGTTTGAGAATGTTGTA
GCCATGAAGGTTGGCGACAAGAGGGACATCTCACGGTTCCTGGAGTGTAATCCAGTGATG
ATTGATGCCATCAAAGTTTCTGCTGCTCACAGGGCCCGATACTTCTGGGGCAACCTACCC
GGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGT
GGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTC
GCCCCTCTGAAGGACTACTTTGCATGTGAATAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF156487

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_3_Locus:
20q11.2

# Macromolecular_Interacting_Partner_3_SNPs:
rs17123590; rs2424922; rs6058891; rs17123657; rs6119965; rs875040; rs2424909; rs1883729; rs2424907; rs2424906; rs2424908; rs4911256; rs6058883; rs6119951; rs2424932; rs6119954; rs4911257; rs742630; rs1333469; rs4911254; rs6058875; rs2424905; rs4544521; rs6141813; rs6058896; rs6058874; rs2018002; rs1855349; rs6087420; rs6141812; rs6087999; rs10485500; rs4911255; rs1569686; rs1003521; rs6141807; rs6141811; rs6087995; rs6141806; rs2424904; rs6119282; rs6058872; rs6057641; rs11699834; rs11907740; rs8115823; rs13433362; rs6058880; rs17123571; rs4911253; rs2424910; rs2889703; rs2065576; rs2424915; rs910085; rs2424918; rs992472; rs6058893; rs4911110; rs4911107; rs2424914; rs6088008; rs2424913; rs6119967; rs4911263; rs875041; rs4911258; rs2424921; rs6058887; rs6119955; rs6057645; rs910084; rs4911261; rs660291; rs998382; rs6119285; rs2424928; rs6057648; rs4911260; rs910083; rs4911259; rs1003522; rs2424923; rs2235758; rs2424930; rs709046; rs6119969; rs4911262; rs6058888; rs4911108; rs2064350; rs1997797; rs6057647; rs1040553; rs8115360; rs1855350; rs1040555; rs6119968; rs2889702; rs2424924; rs7360212; rs1474738; rs2424920; rs6058889; rs1040554; rs17123621; rs6119284; rs1569687; rs6141814; rs2424926; rs2424917; rs6058894; rs2377668; rs6119962; rs6119957; rs17123658; rs6119286; rs17368519; rs2235759; rs6058890; rs6058892; rs2424925; rs1569688; rs2424912; rs993419; rs6119961; rs6119964; rs2424929; rs2424931; rs6058869; rs6087990; rs2424903; rs7263832; rs6058868; rs6141816; rs35846833; rs7354578; rs17123655; rs730823; rs35216603; rs6058885; rs6088005; rs11472205; rs2780646; rs35171367; rs2745869; rs3080493; rs33962299; rs6058884; rs6088001; rs35710599; rs11471852; rs11470764; rs6119953; rs11474600; rs11449585; rs35285794; rs28651027; rs7508830; rs6087992; rs2745868; rs35907993; rs13040503; rs35097322; rs6088003; rs35850884; rs6058876; rs15475; rs13433248; rs35056918; rs6087996; rs6058881; rs13036475; rs6087994; rs35015134; rs2889701; rs2424911; rs12185796; rs6058878; rs8119520; rs6087998; rs6141810; rs34614068; rs5841115; rs34007401; rs34062797; rs6058879; rs11482399; rs7272387; rs34168690; rs6057640; rs11449584; rs11483043; rs13433366; rs2780645; rs10625883; rs8182693; rs6088000; rs10633411; rs35041039; rs11356349; rs35554139; rs6119971; rs853855; rs6141805; rs7264790; rs6058882; rs34988842; rs6087991; rs2284645; rs11367842; rs35262859; rs33960116; rs6058877; rs35649229; rs3215552; rs13036474; rs6119952; rs6087997; rs6058871; rs6087993; rs35767454; rs4578931; rs34551940; rs6088002; rs6141809; rs6057642; rs35572823; rs10690184; rs2780644; rs34237297; rs28377882; rs6088011; rs11467304; rs11367843; rs35272629; rs35965317; rs11469900; rs11482544; rs6119966; rs6088004; rs6088010; rs4911109; rs34031725; rs2268319; rs6119960; rs4571133; rs34902104; rs6119970; rs11469402; rs34013500; rs6088006; rs6141817; rs8115015; rs11483143; rs11469349; rs35213238; rs35130294; rs34002628; rs2424916; rs6058895; rs11469084; rs33932894; rs11477763; rs1079957; rs5841117; rs11389019; rs6057643; rs33979693; rs6141347; rs35246123; rs11472645; rs35576810; rs35722862; rs34292062; rs2424919; rs34005307; rs11167180; rs11482880; rs35255239; rs33912850; rs8117681; rs35427476; rs863831; rs35994043; rs35507532; rs854575; rs8119395; rs34716138; rs3787143; rs36098970; rs2424927; rs863832; rs6088007; rs11697520; rs17123660; rs7354629; rs11480089; rs35541717; rs6088009; rs6141815; rs3838010; rs6119959; rs6119958; rs8119391; rs860549; rs41289866; rs6057644; rs11480729; rs11483142; rs34505873; rs33983546; rs10623814; rs11468163; rs865556; rs2300418; rs6119956; rs6058886; rs17123659; rs11449390; rs36039389; rs34072569; rs11431333; rs3080497; rs5841116; rs35928966; rs34371048; rs11471253; rs35691828; rs36133386; rs36233103; rs35155241; rs6058870; rs35471481; rs3092509; rs11470398; rs13038956; rs2424901; rs242542; rs242543; rs406193; rs437302; rs6058864; rs6058897; rs6141803; rs8118663; rs853858

# Macromolecular_Interacting_Partner_3_General_References:
10433969; 10647011; 11780052; 10325416; 11735126; 10555141; 10588719; 11102980

# Macromolecular_Interacting_Partner_3_References:
16247458

End of HMDB00014

Beginning of HMDB00015
# Accession_No:
HMDB00015

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 11:59:15

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Cortexolone

# Description:
Cortexolone is the precursor of cortisol. Accumulation of Cortexolone can happen in a defect known as congenital adrenal hyperplasia, which is due to 11-beta-hydroxylase deficiency, resulting in androgen excess, virilization, and hypertension. (PMID: 2022736)
A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities. (PubChem)

# Synonyms:
11-Deoxy-17-hydroxycorticosterone; 11-Deoxycortisol; 11-Deoxyhydrocortisone; 11-Desoxy-17-hydroxycorticosterone; 11-Desoxycortisol; 11-Desoxyhydrocortisone; 11-Dioxycortisol; 11-deoxy-17-hydroxy-Corticosterone; 11-deoxy-Cortisol; 11-dioxy-Cortisol; 17,21-Dihydroxy-4-pregnene-3,20-dione; 17,21-Dihydroxyprogesterone; 17,21-dihydroxypregn-4-ene-3,20-dione; 17-Hydroxy-11-deoxycorticosterone; 17alpha-Hydroxycortexone; 20-dione 17,21-Dihydroxypregn-4-ene-3; 4-Pregnene-17alpha,21-diol-3,20-dione; Cortodoxone; Reichstein S; Reichstein's compound S; Reichstein's substance S

# Chemical_IUPAC_Name:
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

# Chemical_Formula:
C21H30O4

# Chemical_Structure:
tbl_chemical:::HMDB00015_ZOOM.png:::119283128571260145

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00015_THUMB.png:::11928312836578974

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; tertiary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
346.21442

# Molecular_Weight_Avg:
346.46048

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2(O)C(=O)CO

# KEGG_Compound_ID:
C05488

# BioCyc_ID:
11-DEOXY-CORTISOL

# PubChem_CID:
440707

# PubChem_SID:
3135470; 7978569; 7847; 855521; 10298640; 841445

# OMIM_ID:
201910; 202010

# Metagene_ID:
Not Available

# BiGG_ID:
45914

# Wikipedia_ID:
Cortexolone

# METLIN_ID:
5088

# Ref_ID:
14709852; 15887869; 15755848; 15834216; 1034356; 15985474; 15807871; 6296182; 8081391; 8169562; 15780662; 15780661; 2808702; 1024042; 8890720; 3515819; 1775135

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
152-58-9

# InChI:
InChI=1/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

# Synthesis_Reference:
Reichstein, T. et al., Helv. Chim. Acta, 1938, 21, 1197; Gallagher, T.F. et al., J.A.C.S., 1949, 71, 3262; Julian, P.L. et al., J.A.C.S., 1950, 72, 5145; Smit, A. et al., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1966, 85, 731; Numazawa, M. et al., J.O.C

# Melting_Point:
215 oC

# Melting_Point_predicted:
134.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.0152 mg/mL [MEYLAN,WM et al. (1996)]; 0.025 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.08 [SANGSTER (1994)]

# LogP_predicted:
2.79 [Predicted by ALOGPS]; 2.4 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00015_msds.html:::1132562189674255972

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05488.mol:::1132723801234275481

# SDF_File_[Text]:
tbl_chemical:::HMDB00015.sdf:::119283127510569589

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00015.pdb:::119283128197747074

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00015_Cortexolone.zip:::11824586056999360

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P00_08_BA_assigned.png:::118245860572214836

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128.png:::116630659547436913

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128.zip:::116630659549941688

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P00_08_BA_2DHSQC_128_Assigned.png:::11663065956525452

# Predicted_H_NMR_Spectrum:
tbl_chemical:::11-Deoxycortisol.gif:::113273209887592709

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00015_peaks.txt:::1156309485183526740

# Predicted_C_NMR_Spectrum:
tbl_chemical:::11-Deoxycortisol_C.gif:::1132737657367523084

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00015_peaks.txt:::1156310677207554521

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00015L.png:::117555266484326892; Medium Energy:tbl_ms:::HMDB00015M.png:::11755527050296668; High Energy:tbl_ms:::HMDB00015H.png:::117555272537225719

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm (Predicted from Solubility); Cytoplasm; endoplasmic reticulum; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.017-178.9	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	3515819
Urine	0.02 (0.0091-0.032)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	6296182
Blood	< 0.023	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	0.0039 +/- 0.0004	uM	Adult:>18_yrs_old	Both	Normal	8890720


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Adrenal Cortical Dysfunction (11B-hydroxylase Deficiency); Congenital Adrenal Hyperplasia

# Pathway_Names:
C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;

# KEGG_Images:
map00140;map00150

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5808

# Metabolic_Enzyme_1_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_1_Gene_Name:
CYP11B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_1_Number_of_Residues:
503

# Metabolic_Enzyme_1_Molecular_Weight:
57561

# Metabolic_Enzyme_1_Theoretical_pI:
9.78

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_1_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_1_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CYP11B2

# Metabolic_Enzyme_1_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q21-q22

# Metabolic_Enzyme_1_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_1_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5809

# Metabolic_Enzyme_3_Name:
Cytochrome P450 21

# Metabolic_Enzyme_3_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_3_Gene_Name:
CYP21A2

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_3_Number_of_Residues:
494

# Metabolic_Enzyme_3_Molecular_Weight:
55888

# Metabolic_Enzyme_3_Theoretical_pI:
7.90

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_3_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP21A2

# Metabolic_Enzyme_3_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_3_Locus:
6p21.3

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5683

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_4_Gene_Name:
CYP11B1

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57530

# Metabolic_Enzyme_4_Theoretical_pI:
9.42

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_4_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
1-23

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_4_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B1

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21

# Metabolic_Enzyme_4_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_4_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5738

# Metabolic_Enzyme_5_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_5_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_5_Gene_Name:
HSD3B1

# Metabolic_Enzyme_5_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_5_Number_of_Residues:
373

# Metabolic_Enzyme_5_Molecular_Weight:
42252

# Metabolic_Enzyme_5_Theoretical_pI:
8.98

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_5_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_5_Signals:
1-13

# Metabolic_Enzyme_5_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_5_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
HSD3B1

# Metabolic_Enzyme_5_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5675

# Metabolic_Enzyme_6_Name:
Tryptophan 2,3-dioxygenase

# Metabolic_Enzyme_6_Synonyms:
TO; Tryptophan pyrrolase; Tryptophanase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO

# Metabolic_Enzyme_6_Gene_Name:
TDO2

# Metabolic_Enzyme_6_Protein_Sequence:
>Tryptophan 2,3dioxygenase
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD

# Metabolic_Enzyme_6_Number_of_Residues:
406

# Metabolic_Enzyme_6_Molecular_Weight:
47872

# Metabolic_Enzyme_6_Theoretical_pI:
6.93

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
Function:  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Function:  tryptophan 2,3-dioxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  indolalkylamine metabolism
Process:  tryptophan metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin

# Metabolic_Enzyme_6_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_6_Reaction:
L-tryptophan + O2 = L-formylkynurenine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF03301:Trp_dioxygenase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.13.11.11

# Metabolic_Enzyme_6_GenBank_ID_Protein:
993046

# Metabolic_Enzyme_6_SwissProt_ID:
T23O_HUMAN (P48775)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TDO2

# Metabolic_Enzyme_6_Geneatlas_id:
TDO2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11708

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1221 bp
ATGAGTGGGTGCCCATTTTTAGGAAACAACTTTGGATATACTTTTAAAAAACTCCCCGTA
GAAGGCAGCGAAGAAGACAAATCACAAACTGGTGTGAATAGAGCCAGCAAAGGAGGTCTT
ATCTATGGGAACTACCTGCATTTGGAAAAAGTTTTGAATGCACAAGAACTGCAAAGTGAA
ACAAAAGGAAATAAAATCCATGATGAACATCTTTTTATCATAACTCATCAAGCTTATGAA
CTCTGGTTTAAGCAAATCCTCTGGGAGTTGGATTCTGTTCGAGAGATCTTTCAGAATGGC
CATGTCAGAGATGAAAGGAACATGCTTAAGGTTGTTTCTCGGATGCACCGAGTGTCAGTG
ATCCTGAAACTGCTGGTGCAGCAGTTTTCCATTCTGGAGACGATGACAGCCTTGGACTTC
AATGACTTCAGAGAGTACTTATCTCCAGCATCAGGCTTCCAGAGTTTGCAATTCCGACTA
TTAGAAAACAAGATAGGTGTTCTTCAGAACATGAGAGTCCCTTATAACAGAAGACATTAT
CGTGATAACTTCAAAGGAGAAGAAAATGAACTGCTACTTAAATCTGAGCAGGAAAAGACA
CTTCTGGAATTAGTGGAGGCATGGCTGGAAAGAACTCCAGGTTTAGAGCCACATGGATTT
AACTTCTGGGGAAAGCTTGAAAAAAATATCACCAGAGGCCTGGAAGAGGAATTCATAAGG
ATTCAGGCTAAAGAAGAGTCTGAAGAAAAAGAGGAACAGGTGGCTGAATTTCAGAAGCAA
AAAGAGGTGCTACTGTCCTTATTTGATGAGAAACGTCATGAACATCTCCTTAGTAAAGGT
GAAAGACGGCTGTCATACAGAGCACTTCAGGGAGCATTGATGATATATTTTTACAGGGAA
GAGCCTAGGTTCCAGGTGCCTTTTCAGTTGCTGACTTCTCTTATGGACATAGATTCACTG
ATGACCAAATGGAGATATAACCATGTGTGCATGGTGCACAGAATGCTGGGCAGCAAAGCT
GGCACCGGTGGTTCCTCAGGCTATCACTACCTGCGATCAACTGTGAGTGATAGGTACAAG
GTATTTGTAGATTTATTTAATCTTTCAACATACCTGATTCCCCGACACTGGATACCGAAG
ATGAACCCAACCATTCACAAATTTCTATATACAGCAGAATACTGTGATAGCTCCTACTTC
AGCAGTGATGAATCAGATTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U32989

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q31-q32

# Metabolic_Enzyme_6_SNPs:
rs2271537; rs2878125; rs6830072; rs7674417; rs11723579; rs10020753; rs6856558; rs2137778; rs2292536; rs2292537; rs6536122; rs12646333; rs6830800; rs6817205; rs2271538; rs2048652; rs13128945; rs10517626; rs12502494; rs9307937; rs16998970; rs3796552; rs13107510; rs10034841; rs9307936; rs10018290; rs6828277; rs17033777; rs3839139; rs12510023; rs3796551; rs3839140; rs13125676; rs13434811; rs13152449; rs13107055; rs3755908; rs10857287; rs11935082; rs3775085; rs17033763; rs3755909; rs17379913; rs3775086; rs3836580; rs6856687; rs11541501; rs28601721; rs1399049; rs34837968; rs34847339; rs34167914; rs10595404; rs35761138; rs13148802; rs34133854; rs34184093; rs28369464; rs10598060; rs35631700; rs28683807; rs6810476; rs35929431; rs28446368; rs13128538; rs34104412; rs17033790; rs3965794; rs1399043; rs13435334; rs35493540; rs11273681; rs28452752; rs13106862; rs11732472; rs3796554; rs28420292; rs28538165; rs34051837; rs13101532; rs34991756; rs3796553; rs13152593; rs3755910; rs7697993; rs3836581; rs10163; rs10517627; rs17033799; rs17379906; rs3755907; rs3775084; rs573; rs6536119; rs6839640; rs6856354; rs9044

# Metabolic_Enzyme_6_General_References:
8666386

# Metabolic_Enzyme_6_References:
4050454; 6103800

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
12571170; 1322161; 1330379; 1339134

# Macromolecular_Interacting_Partner_2_ID:
7546

# Macromolecular_Interacting_Partner_2_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
PRL

# Macromolecular_Interacting_Partner_2_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-28

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_2_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_2_References:
9547720

# Macromolecular_Interacting_Partner_3_ID:
7297

# Macromolecular_Interacting_Partner_3_Name:
Glucocorticoid receptor

# Macromolecular_Interacting_Partner_3_Synonyms:
GR

# Macromolecular_Interacting_Partner_3_Gene_Name:
NR3C1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
777

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
85660

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  glucocorticoid receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF02155:GCR;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
31680

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
GCR_HUMAN (P04150)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NR3C1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NR3C1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7978

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2334 bp
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X03225

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5q31.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs6192; rs6190; rs6195; rs6196; rs6189; rs6194; rs258751; rs6199; rs6193; rs4912910; rs6191; rs10052957; rs7701443; rs4912909; rs12656106; rs4607376; rs4244032; rs4403203; rs9324924; rs5871845; rs4912911; rs9324922; rs6198; rs10482605; rs10477211; rs13185164; rs13162395; rs4529231; rs4582314; rs4244031; rs10482611; rs10482620; rs12513857; rs6865292; rs4457111; rs9324923; rs4634384; rs11167811; rs6896209; rs4518434; rs12655166; rs10482609; rs4912912; rs10482616; rs11749561; rs13182800; rs10482603; rs10482617; rs10482707; rs17302697; rs10482610; rs10482714; rs4406157; rs7719514; rs17100289; rs6197; rs3806854; rs13186836; rs4518436; rs7723528; rs10482614; rs13170129; rs6882102; rs28364694; rs13153270; rs10482712; rs13155635; rs11747997; rs12653301; rs10043090; rs13184611; rs11167810; rs10482716; rs2301177; rs3806855; rs12054797; rs12515985; rs2918417; rs2918416; rs1866388; rs852980; rs33388; rs258813; rs6188; rs2963156; rs258750; rs852977; rs2918418; rs6877893; rs4986593; rs9324915; rs6866890; rs852982; rs1438732; rs2918419; rs9324914; rs10041520; rs12652915; rs10078410; rs4912905; rs10054283; rs852978; rs864082; rs33389; rs17209251; rs10482625; rs9324916; rs852976; rs10515522; rs2043840; rs10482655; rs2963145; rs9324918; rs12386466; rs11740792; rs11955803; rs9324917; rs2963152; rs9324921; rs4128428; rs10042644; rs258814; rs2118727; rs2398631; rs9324913; rs10482640; rs13355103; rs4912650; rs10482641; rs10482665; rs9324920; rs10482634; rs10482636; rs6871322; rs7716360; rs17100234; rs11745958; rs9324912; rs17339831; rs10482650; rs13358709; rs10482682; rs1438731; rs2963146; rs10515521; rs9324911; rs10482633; rs190488; rs852981; rs10482672; rs10482642; rs10482637; rs13306587; rs852979; rs10482630; rs13176292; rs2918415; rs10066267; rs10482646; rs10482668; rs17100236; rs10482669; rs10482654; rs10482679; rs10482704; rs10076665; rs2963155; rs11740747; rs10482631; rs17209258; rs4912907; rs10482676; rs10482681; rs2918421; rs10482701; rs10482688; rs10482638; rs10482689; rs13360865; rs1837262; rs17339455; rs10482686; rs13360160; rs10482667; rs13353867; rs10072193; rs10071869; rs10038016; rs852975; rs13171962; rs10482700; rs10482643; rs12109552; rs11750172; rs10045381; rs10482658; rs10055443; rs10041957; rs10042903; rs17399352; rs10482626; rs10482653; rs7730946; rs10076037; rs10482675; rs13178847; rs6861962; rs2963151; rs10040972; rs10042897; rs10042042; rs10053679; rs33380; rs10482659; rs2307674; rs3776216; rs10482690; rs13186482; rs10482628; rs10041040; rs13180461; rs2963154; rs12655424; rs9324919; rs10060545; rs10482645; rs1305061; rs11742942; rs3822376; rs34562334; rs10043707; rs10482698; rs10055444; rs10051482; rs10482693; rs10482623; rs10482683; rs17100237; rs13353891; rs13361140; rs10482639; rs2963149; rs10038464; rs860457; rs258747; rs6868190; rs17287758; rs258748; rs17209237; rs33391; rs1800445; rs10482622; rs13306589; rs13306588; rs13160969; rs11292842; rs10482621; rs10482618; rs35515833; rs13166252; rs10482608; rs13173940; rs10482606; rs35257270; rs10477210; rs5871844; rs5871846; rs34113205; rs13306586; rs4585488; rs34519266; rs6187; rs35726834; rs28546630; rs10482619; rs10482612; rs13306585; rs33978809; rs34580792; rs13166717; rs33968115; rs35132206; rs4244033; rs34123577; rs10482711; rs10482706; rs35956102; rs4441905; rs4075426; rs35159833; rs28392717; rs35174661; rs4912908; rs10577951; rs36208514; rs34471178; rs10482708; rs35314635; rs36028129; rs28635164; rs4367320; rs35715139; rs34248080; rs10482613; rs34027900; rs10482709; rs10482713; rs35555700; rs35500391; rs34449288; rs6894830; rs35728985; rs10482710; rs10482604; rs13178409; rs34207899; rs12652149; rs10482607; rs34226461; rs13176328; rs1803634; rs34861052; rs10440742; rs35224915; rs35722527; rs4434414; rs5871847; rs13169606; rs36029993; rs35296125; rs12189168; rs34569272; rs10482615; rs35612073; rs34961947; rs35290813; rs28609103; rs10043662; rs4388235; rs34396341; rs10482715; rs36208517; rs11552272; rs5871843; rs35572256; rs10482657; rs10482691; rs13158118; rs10038827; rs34523349; rs35918104; rs35271349; rs10043423; rs4912906; rs10477206; rs10482661; rs2398628; rs10482678; rs35786621; rs10482677; rs33963148; rs35947578; rs13358784; rs10482680; rs35598337; rs35023410; rs35592572; rs9654496; rs13169116; rs13359753; rs13356889; rs10053963; rs10477207; rs35020221; rs34756958; rs36027185; rs35396295; rs34641849; rs10037525; rs34808627; rs174050; rs2079687; rs34530390; rs10482644; rs3836768; rs28865014; rs4608948; rs34209560; rs10039663; rs10482647; rs10482670; rs10477208; rs860458; rs34841797; rs13169117; rs2963147; rs36008199; rs10042038; rs34427874; rs10482697; rs2963150; rs3861852; rs35245606; rs35176817; rs10062225; rs10477209; rs34535209; rs10482629; rs10073248; rs34319493; rs2022117; rs34780316; rs10482660; rs35624123; rs35302985; rs35299297; rs10482635; rs1140000; rs13306584; rs34194480; rs7715728; rs34260076; rs7734158; rs10482649; rs28822503; rs34638922; rs36090270; rs28453280; rs10045200; rs34152766; rs10482696; rs34346366; rs34743734; rs10055574; rs35527602; rs10035222; rs36010586; rs10037693; rs10482664; rs10482684; rs10482652; rs10482627; rs28821527; rs10482673; rs10482674; rs10482703; rs2963148; rs10060741; rs10482695; rs10053200; rs41423247; rs35655055; rs852974; rs10054713; rs10482624; rs34827388; rs34686112; rs10482692; rs35667604; rs10482694; rs35039262; rs2398629; rs34992369; rs10482687; rs35713866; rs10482685; rs2918420; rs10482666; rs35502804; rs10482648; rs10477204; rs33952897; rs36027730; rs34778988; rs10036278; rs2282800; rs11395012; rs33382; rs10042945; rs13361442; rs10036628; rs35923465; rs35999293; rs35241746; rs10214015; rs4912904; rs10041074; rs6882247; rs28791803; rs10482662; rs10482699; rs34186246; rs34494535; rs35434651; rs10482671; rs10482632; rs10482705; rs13355270; rs33944801; rs34632939; rs2963153; rs33381; rs35507823; rs34176759; rs34763421; rs10482656; rs34340042; rs10482702; rs10065326; rs6873841; rs36105398; rs10482651; rs35696265; rs185434; rs10079976; rs10036734; rs35335992; rs11378193; rs34911720; rs10482663; rs4437403; rs34019216; rs35067504; rs10482717; rs34876003; rs10041406; rs12519083; rs12521436; rs13190019; rs17287745; rs174048; rs258763; rs33383; rs4912913; rs7448383; rs7701582; rs7709864; rs7728835

# Macromolecular_Interacting_Partner_3_General_References:
2867473; 1707881; 2026589; 1958537; 11435610; 3841189; 9154805; 9590696; 10477749; 10566686; 8358712; 10902803; 10866662; 10639135; 11555652; 11238589; 12144530; 12000743; 12415108; 12151000; 12686538; 1704018; 8358735; 8445027; 7683692; 8316249; 9150737; 10391209; 10898924; 11589680; 11344238; 11701741; 11932321; 12050230

# Macromolecular_Interacting_Partner_3_References:
1971967; 3491118; 3741883; 6188228

End of HMDB00015

Beginning of HMDB00016
# Accession_No:
HMDB00016

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-15 10:45:19

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Deoxycorticosterone

# Description:
A steroid or mineralocorticoid secreted by the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone.  It can be used to treat adrenal insufficiency.  In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease.

# Synonyms:
11-Dehydroxycorticosterone; 11-Deoxycorticosterone; 11-Desoxycorticosterone; 11-deoxy-Corticosterone; 21-Hydroxy-3,20-dioxopregn-4-ene; 21-Hydroxy-D4-pregnane-3,20-dione; 21-Hydroxy-D4-pregnene-3,20-dione; 21-Hydroxypregn-4-ene-3,20-dione; 21-Hydroxyprogesterone; 21-hydroxy-Pregn-4-ene-3,20-dione; 21-hydroxy-Progesterone; 4-Pregnen-21-ol-3,20-dione; Cortexone; D4-Pregnene-21-ol-3,20-dione; DOC; Deoxycortone; Desoxycorticosterone; Desoxycortone; Doca; Kendall's desoxy compound B; Reichstein's substance Q

# Chemical_IUPAC_Name:
17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

# Chemical_Formula:
C21H30O3

# Chemical_Structure:
tbl_chemical:::HMDB00016_ZOOM.png:::11928313002392616

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00016_THUMB.png:::119283129809184044

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids; Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; primary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
330.21948

# Molecular_Weight_Avg:
330.46109

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2C(=O)CO

# KEGG_Compound_ID:
C03205

# BioCyc_ID:
11-DEOXYCORTICOSTERONE

# PubChem_CID:
6166

# PubChem_SID:
11466985; 149067; 8153870; 3136426; 6081; 11486839; 11468105; 855538; 8144739; 841768; 7885076

# OMIM_ID:
138040; 201910; 202010; 203400

# Metagene_ID:
11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1): 458; 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17): 321

# BiGG_ID:
41397

# Wikipedia_ID:
Deoxycorticosterone

# METLIN_ID:
5089

# Ref_ID:
11423756; 2164659; 15181062; 7462398; 1751389; 1423019; 12119960; 15483094; 16112410; 15947887; 15134803; 8081391; 15117882; 15816373; 1555868; 15780662; 2808702; 871129; 15167270; 9746224

# ChEBI_ID:
16973

# CAS_Registry_Number:
64-85-7

# InChI:
InChI=1/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1

# Synthesis_Reference:
Schindler, W. etal., Helv. Chim. Acta, 1941, 24, 371; Zaffaroni, A. etal., Experientia, 1955, 11, 219; U.S. Pat., 1966, 3 254 098 CA, 65, 8999; van der Sijde, D. etal., Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1969, 88, 1437; Numazawa, M. etal., J.O.C.,

# Melting_Point:
141-142 oC

# Melting_Point_predicted:
129.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0595 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.0167 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
2.88 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.10 [Predicted by ALOGPS]; 2.5 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C03205.mol:::1132723801328422785

# SDF_File_[Text]:
tbl_chemical:::HMDB00016.sdf:::119283128975077223

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00016.pdb:::11928312964036270

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050118_P00_07_IS_1DP.zip:::117104462555686060

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_07_IS_assigned.png:::119205470912749991

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050118_P00_07_IS_207.png:::11924667192104559

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050118_P00_07_IS_207.zip:::119246671927742914

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050118_P00_07_IS_207_Assigned.png:::119246671953182530

# Predicted_H_NMR_Spectrum:
tbl_chemical:::11-Deoxycorticosterone.gif:::1132732098921318004

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00016_peaks.txt:::1156309486195670785

# Predicted_C_NMR_Spectrum:
tbl_chemical:::11-Deoxycorticosterone_C.gif:::1132737657447977146

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00016_peaks.txt:::1156310678215166512

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00016L.png:::117555263001070051; Medium Energy:tbl_ms:::HMDB00016M.png:::117555268387782026; High Energy:tbl_ms:::HMDB00016H.png:::117555271680463630

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Amniotic Fluid; Blood

# Concentration_[Normal]:
Blood	0.073 (0.034-0.11)	uM	Adult:>18_yrs_old	Female	Normal	12119960


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
11-Hydroxylase Deficiency; 17-Hydroxylase Deficiency; Adrenal Adenoma; Congenital Adrenal Hyperplasia; Malignant Hypertension

# Pathway_Names:
C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;

# KEGG_Images:
map00140;map00150

# Pathway_Graphs:
;

# Pathway_SBMLs:
;

# Metabolic_Enzyme_1_ID:
5737

# Metabolic_Enzyme_1_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_1_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_1_Gene_Name:
HSD3B2

# Metabolic_Enzyme_1_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_1_Number_of_Residues:
372

# Metabolic_Enzyme_1_Molecular_Weight:
42053

# Metabolic_Enzyme_1_Theoretical_pI:
8.17

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_1_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_1_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_1_Signals:
1-15

# Metabolic_Enzyme_1_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_1_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HSD3B2

# Metabolic_Enzyme_1_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_1_Locus:
1p13.1

# Metabolic_Enzyme_1_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_1_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5738

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B1

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
373

# Metabolic_Enzyme_2_Molecular_Weight:
42252

# Metabolic_Enzyme_2_Theoretical_pI:
8.98

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-13

# Metabolic_Enzyme_2_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B1

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5683

# Metabolic_Enzyme_3_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_3_Gene_Name:
CYP11B1

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_3_Number_of_Residues:
503

# Metabolic_Enzyme_3_Molecular_Weight:
57530

# Metabolic_Enzyme_3_Theoretical_pI:
9.42

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_3_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP11B1

# Metabolic_Enzyme_3_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_3_Locus:
8q21

# Metabolic_Enzyme_3_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_3_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5808

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_4_Gene_Name:
CYP11B2

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57561

# Metabolic_Enzyme_4_Theoretical_pI:
9.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_4_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_4_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B2

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21-q22

# Metabolic_Enzyme_4_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_4_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5809

# Metabolic_Enzyme_5_Name:
Cytochrome P450 21

# Metabolic_Enzyme_5_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_5_Gene_Name:
CYP21A2

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_5_Number_of_Residues:
494

# Metabolic_Enzyme_5_Molecular_Weight:
55888

# Metabolic_Enzyme_5_Theoretical_pI:
7.90

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_5_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_5_Signals:
1-15

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_5_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CYP21A2

# Metabolic_Enzyme_5_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_5_Locus:
6p21.3

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
7375

# Metabolic_Enzyme_6_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
SOD2

# Metabolic_Enzyme_6_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_6_Number_of_Residues:
222

# Metabolic_Enzyme_6_Molecular_Weight:
24722

# Metabolic_Enzyme_6_Theoretical_pI:
8.45

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_6_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
SOD2

# Metabolic_Enzyme_6_Geneatlas_id:
SOD2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_6_PDB_ID:
1LUV

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_6_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_6_Locus:
6q25.3

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_6_References:
12600921; 12925450; 15124912

# Metabolic_Enzyme_7_ID:
8038

# Metabolic_Enzyme_7_Name:
Neprilysin

# Metabolic_Enzyme_7_Synonyms:
Neutral endopeptidase; NEP; Enkephalinase; Neutral endopeptidase 24.11; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; CD10 antigen

# Metabolic_Enzyme_7_Gene_Name:
MME

# Metabolic_Enzyme_7_Protein_Sequence:
>Neprilysin
MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW

# Metabolic_Enzyme_7_Number_of_Residues:
750

# Metabolic_Enzyme_7_Molecular_Weight:
85515

# Metabolic_Enzyme_7_Theoretical_pI:
5.43

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  endopeptidase activity
Function:  metalloendopeptidase activity
Function:  neprilysin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_7_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Metabolic_Enzyme_7_Specific_Function:
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF)

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF01431:Peptidase_M13;
PF05649:Peptidase_M13_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
29-51

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.4.24.11

# Metabolic_Enzyme_7_GenBank_ID_Protein:
34758

# Metabolic_Enzyme_7_SwissProt_ID:
NEP_HUMAN (P08473)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
MME

# Metabolic_Enzyme_7_Geneatlas_id:
MME

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7154

# Metabolic_Enzyme_7_PDB_ID:
1DMT

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>2232 bp
ATGGATATAACTGATATCAACACTCCAAAGCCAAAGAAGAAACAGCGATGGACTCCACTG
GAGATCAGCCTCTCGGTCCTTGTCCTGCTCCTCACCATCATAGCTGTGACAATGATCGCA
CTCTATGCAACCTACGATGATGGTATTTGCAAGTCATCAGACTGCATAAAATCAGCTGCT
CGACTGATCCAAAACATGGATGCCACCACTGAGCCTTGTACAGACTTTTTCAAATATGCT
TGCGGAGGCTGGTTGAAACGTAATGTCATTCCCGAGACCAGCTCCCGTTACGGCAACTTT
GACATTTTAAGAGATGAACTAGAAGTCGTTTTGAAAGATGTCCTTCAAGAACCCAAAACT
GAAGATATAGTAGCAGTGCAGAAAGCAAAAGCATTGTACAGGTCTTGTATAAATGAATCT
GCTATTGATAGCAGAGGTGGAGAACCTCTACTCAAACTGTTACCAGACATATATGGGTGG
CCAGTAGCAACAGAAAACTGGGAGCAAAAATATGGTGCTTCTTGGACAGCTGAAAAAGCT
ATTGCACAACTGAATTCTAAATATGGGAAAAAAGTCCTTATTAATTTGTTTGTTGGCACT
GATGATAAGAATTCTGTGAATCATGTAATTCATATTGACCAACCTCGACTTGGCCTCCCT
TCTAGAGATTACTATGAATGCACTGGAATCTATAAAGAGGCTTGTACAGCATATGTGGAT
TTTATGATTTCTGTGGCCAGATTGATTCGTCAGGAAGAAAGATTGCCCATCGATGAAAAC
CAGCTTGCTTTGGAAATGAATAAAGTTATGGAATTGGAAAAAGAAATTGCCAATGCTACG
GCTAAACCTGAAGATCGAAATGATCCAATGCTTCTGTATAACAAGATGACATTGGCCCAG
ATCCAAAATAACTTTTCACTAGAGATCAATGGGAAGCCATTCAGCTGGTTGAATTTCACA
AATGAAATCATGTCAACTGTGAATATTAGTATTACAAATGAGGAAGATGTGGTTGTTTAT
GCTCCAGAATATTTAACCAAACTTAAGCCCATTCTTACCAAATATTCTGCCAGAGATCTT
CAAAATTTAATGTCCTGGAGATTCATAATGGATCTTGTAAGCAGCCTCAGCCGAACCTAC
AAGGAGTCCAGAAATGCTTTCCGCAAGGCCCTTTATGGTACAACCTCAGAAACAGCAACT
TGGAGACGTTGTGCAAACTATGTCAATGGGAATATGGAAAATGCTGTGGGGAGGCTTTAT
GTGGAAGCAGCATTTGCTGGAGAGAGTAAACATGTGGTCGAGGATTTGATTGCACAGATC
CGAGAAGTTTTTATTCAGACTTTAGATGACCTCACTTGGATGGATGCCGAGACAAAAAAG
AGAGCTGAAGAAAAGGCCTTAGCAATTAAAGAAAGGATCGGCTATCCTGATGACATTGTT
TCAAATGATAACAAACTGAATAATGAGTACCTCGAGTTGAACTACAAAGAAGATGAATAC
TTCGAGAACATAATTCAAAATTTGAAATTCAGCCAAAGTAAACAACTGAAGAAGCTCCGA
GAAAAGGTGGACAAAGATGAGTGGATAAGTGGAGCAGCTGTAGTCAATGCATTTTACTCT
TCAGGAAGAAATCAGATAGTCTTCCCAGCCGGCATTCTGCAGCCCCCCTTCTTTAGTGCC
CAGCAGTCCAACTCATTGAACTATGGGGGCATCGGCATGGTCATAGGACACGAAATCACC
CATGGCTTCGATGACAATGGCAGAAACTTTAACAAAGATGGAGACCTCGTTGACTGGTGG
ACTCAACAGTCTGCAAGTAACTTTAAGGAGCAATCCCAGTGCATGGTGTATCAGTATGGA
AACTTTTCCTGGGACCTGGCAGGTGGACAGCACCTTAATGGAATTAATACACTGGGAGAA
AACATTGCTGATAATGGAGGTCTTGGTCAAGCATACAGAGCCTATCAGAATTATATTAAA
AAGAATGGCGAAGAAAAATTACTTCCTGGACTTGACCTAAATCACAAACAACTATTTTTC
TTGAACTTTGCACAGGTGTGGTGTGGAACCTATAGGCCAGAGTATGCGGTTAACTCCATT
AAAACAGATGTGCACAGTCCAGGCAATTTCAGGATTATTGGGACTTTGCAGAACTCTGCA
GAGTTTTCAGAAGCCTTTCACTGCCGCAAGAATTCATACATGAATCCAGAAAAGAAGTGC
CGGGTTTGGTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X07166

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_7_Locus:
3q25.1-q25.2

# Metabolic_Enzyme_7_SNPs:
rs35227300; rs35926730; rs701109; rs7610758; rs12765; rs6794748; rs6665; rs989692; rs3821717; rs1042343; rs1126662; rs3773905; rs9829757; rs968628; rs1436633; rs1025192; rs2118073; rs3773882; rs1807004; rs9881879; rs3773885; rs3773880; rs1807003; rs9849573; rs3773901; rs4679739; rs9847553; rs9830725; rs7649252; rs12493021; rs3796268; rs6440966; rs1370031; rs9853221; rs7431115; rs2196521; rs9827586; rs1436631; rs1836917; rs2016846; rs1436635; rs9846938; rs1836915; rs3773899; rs1385480; rs3773888; rs4273335; rs12696022; rs3821719; rs2007329; rs1812652; rs3773871; rs6804570; rs17383987; rs9832950; rs3736187; rs1436634; rs9829347; rs10804768; rs3773889; rs16824591; rs3773896; rs4607069; rs3773877; rs7433648; rs10513470; rs3773891; rs7618860; rs3773872; rs9864287; rs3816801; rs3816803; rs3773898; rs4273336; rs10513469; rs3773904; rs13086740; rs16824641; rs3732886; rs3773893; rs17443031; rs3773902; rs17449556; rs6800145; rs1816558; rs3773876; rs3773895; rs16824656; rs6776185; rs10513468; rs4405870; rs2016848; rs1436632; rs11719420; rs10804769; rs6801319; rs13077421; rs17442808; rs9831947; rs3773892; rs3736188; rs16824574; rs9713010; rs12489807; rs3821721; rs3773903; rs12635515; rs12490001; rs11713572; rs9867821; rs1836916; rs4611779; rs9864538; rs6763852; rs12496460; rs6773791; rs12638172; rs16824625; rs1436630; rs12495564; rs6798179; rs12632714; rs7626010; rs7633993; rs6801276; rs7629378; rs6763919; rs9856798; rs9289951; rs16824618; rs9713472; rs16824575; rs9839250; rs17384425; rs9827313; rs10935999; rs7639923; rs3773873; rs16824555; rs3732888; rs9874608; rs3773886; rs3836434; rs6797911; rs7639962; rs16824626; rs9834487; rs12638175; rs6804455; rs7625009; rs9819906; rs7648334; rs6785920; rs16824648; rs1385479; rs16824551; rs9713011; rs3773887; rs13065680; rs16824562; rs3773881; rs3773884; rs10935998; rs16824558; rs3773878; rs16824623; rs3773874; rs9876965; rs9844438; rs11925306; rs3836436; rs9854218; rs1836914; rs3773906; rs3773907; rs1042290; rs41267905; rs34931605; rs1062488; rs1126608; rs1062487; rs35152996; rs34147103; rs3213879; rs1042305; rs1803235; rs1042301; rs10611660; rs7648713; rs1042326; rs28673360; rs1042342; rs34385388; rs12176; rs34877913; rs35599824; rs4571206; rs6764041; rs35578452; rs16824596; rs3796267; rs34745881; rs28788259; rs28691749; rs34979254; rs7633703; rs34673569; rs35794019; rs35421413; rs35213254; rs9882981; rs35749393; rs3816802; rs28778887; rs10935997; rs13066247; rs35014314; rs35628546; rs7626284; rs1485239; rs2164555; rs28617565; rs9841712; rs10664276; rs11300412; rs16824559; rs6792240; rs41485544; rs35070142; rs12493386; rs2304504; rs17450609; rs11464401; rs11349976; rs34177891; rs34078518; rs5853716; rs41267911; rs41267907; rs11403666; rs35608418; rs9713095; rs35589959; rs28841298; rs36097668; rs35748450; rs34292929; rs11359933; rs9874874; rs11710357; rs11391196; rs1280064; rs3836437; rs4629293; rs35273441; rs16824569; rs36115413; rs35131344; rs35200999; rs35351972; rs3836439; rs2011753; rs10620895; rs6801016; rs35142333; rs28417610; rs13066242; rs11296151; rs35030915; rs35089203; rs33917850; rs12491360; rs10622201; rs12053875; rs41267903; rs34121569; rs13434182; rs5853713; rs6799300; rs34540478; rs16824635; rs9874896; rs12629968; rs11406128; rs11448605; rs5853715; rs34319615; rs11373874; rs1299661; rs34922274; rs13093233; rs28878180; rs28787412; rs4467412; rs35507229; rs3172398; rs35688638; rs35948931; rs16824624; rs36013310; rs35482420; rs3773879; rs9843813; rs10706442; rs35991584; rs5853712; rs28825395; rs7627068; rs33959610; rs16846958; rs11359866; rs35708164; rs9870542; rs11445808; rs35653282; rs34549615; rs13070260; rs9819744; rs2196522; rs11344677; rs10620043; rs3839085; rs13093231; rs3773890; rs5853714; rs6797549; rs11340092; rs33979604; rs41267909; rs13071013; rs10522735; rs3836438; rs36167758; rs9869317; rs11303845; rs4680153; rs13070729; rs13073702; rs4377457; rs35330405; rs10706860; rs28758831; rs3836433; rs34814906; rs36037593; rs9825415; rs35450782; rs5853711; rs9864458; rs35994024; rs1836913; rs1836912; rs9809268; rs35309296; rs35900633; rs5853710; rs34585642; rs35303134; rs1021216; rs13081581; rs1385475; rs1385476; rs1385477; rs16824536; rs16824538; rs16824540; rs16846960; rs4345034; rs6805925; rs7622933; rs7627426; rs7649865; rs9851460; rs9866659

# Metabolic_Enzyme_7_General_References:
3162217; 2971756; 2968607; 2528730; 8168535; 12754519; 10669592

# Metabolic_Enzyme_7_References:
8064160

# Macromolecular_Interacting_Partner_1_ID:
7542

# Macromolecular_Interacting_Partner_1_Name:
Kininogen-1 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Alpha-2-thiol proteinase inhibitor[Contains: Kininogen-1 heavy chain; Bradykinin; Kallidin I; Lysyl-bradykinin; Kallidin II; Kininogen-1 light chain; Low molecular weight growth- promoting factor]

# Macromolecular_Interacting_Partner_1_Gene_Name:
KNG1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Kininogen1 precursor
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRIT
EATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFS
VATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLN
EVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLR
IASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFK
IDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPW
EKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSG
KEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLD
DDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQE
KTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSF
NPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
644

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
71958

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.80

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  cysteine protease inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects:(4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00031:Cystatin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
177890

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
KNG1_HUMAN (P01042)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
KNG1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
KNG1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6383

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1284 bp
ATGAAACTAATTACCATCCTTTTCCTCTGCTCCAGGCTACTACTAAGTTTAACCCAGGAA
TCACAGTCCGAGGAAATTGACTGCAATGACAAGGATTTATTTAAAGCTGTGGATGCTGCT
CTGAAGAAATATAACAGTCAAAACCAAAGTAACAACCAGTTTGTATTGTACCGCATAACT
GAAGCCACTAAGACGGTTGGCTCTGACACGTTTTATTCCTTCAAGTACGAAATCAAGGAG
GGGGATTGTCCTGTTCAAAGTGGCAAAACCTGGCAGGACTGTGAGTACAAGGATGCTGCA
AAAGCAGCCACTGGAGAATGCACGGCAACCGTGGGGAAGAGGAGCAGTACGAAATTCTCC
GTGGCTACCCAGACCTGCCAGATTACTCCAGCCGAGGGCCCTGTGGTGACAGCCCAGTAC
GACTGCCTCGGCTGTGTGCATCCTATATCAACGCAGAGCCCAGACCTGGAGCCCATTCTG
AGACACGGCATTCAGTACTTTAACAACAACACTCAACATTCCTCCCTCTTCATGCTTAAT
GAAGTAAAACGGGCCCAAAGACAGGTGGTGGCTGGATTGAACTTTCGAATTACCTACTCA
ATTGTGCAAACGAATTGTTCCAAAGAGAATTTTCTGTTCTTAACTCCAGACTGCAAGTCC
CTTTGGAATGGTGATACCGGTGAATGTACAGATAATGCATACATCGATATTCAGCTACGA
ATTGCTTCCTTCTCACAGAACTGTGACATTTATCCAGGGAAGGATTTTGTACAACCACCT
ACCAAGATTTGCGTGGGCTGCCCCAGAGATATACCCACCAACAGCCCAGAGCTGGAGGAG
ACACTGACTCACACCATCACAAAGCTTAATGCAGAGAATAACGCAACTTTCTATTTCAAG
ATTGACAATGTGAAAAAAGCAAGAGTACAGGTGGTGGCTGGCAAGAAATATTTTATTGAC
TTCGTGGCCAGGGAAACCACATGTTCCAAGGAAAGTAATGAAGAGTTGACCGAAAGCTGT
GAGACCAAAAAACTTGGCCAAAGCCTAGATTGCAACGCTGAAGTTTATGTGGTACCCTGG
GAGAAAAAAATTTACCCTACTGTCAACTGTCAACCACTGGGAATGATCTCACTGATGAAA
AGGCCTCCAGGTTTTTCACCTTTCCGATCATCACGAATAGGGGAAATAAAAGAAGAAACA
ACTAGTCACCTAAGGTCCTGCGAGTACAAGGGTCGACCCCCAAAGGCAGGGGCAGAGCCA
GCATCTGAGAGGGAGGTCTCTTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
K02566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_1_Locus:
3q27

# Macromolecular_Interacting_Partner_1_SNPs:
rs2304456; rs5030024; rs1656922; rs5030015; rs1469859; rs5029980; rs1050274; rs5030096; rs5029974; rs1656925; rs2378115; rs1648698; rs5030072; rs710448; rs266760; rs1648697; rs5030022; rs1624569; rs5030023; rs5030002; rs5029999; rs5029979; rs5030020; rs5030094; rs1648722; rs1656914; rs698078; rs1851665; rs5030057; rs5030039; rs5029988; rs5030032; rs1656912; rs5030045; rs5030095; rs1829886; rs1656918; rs5030103; rs1851664; rs5030087; rs5030018; rs5030063; rs1648715; rs5030089; rs5029991; rs4686798; rs1656921; rs5030107; rs5029985; rs5029990; rs1656942; rs1624230; rs1622922; rs5030053; rs5030106; rs1648700; rs5030052; rs5029986; rs822366; rs5030076; rs5030092; rs5030059; rs710449; rs5029992; rs5030011; rs5030069; rs5030043; rs5030028; rs710447; rs5030111; rs3190571; rs822363; rs2689197; rs5030004; rs1621816; rs5030083; rs710446; rs5030051; rs2651640; rs1648716; rs5029987; rs5030033; rs1656910; rs1403694; rs1648712; rs166479; rs7644084; rs1836860; rs5030081; rs5030113; rs5030084; rs1656917; rs822620; rs822624; rs2304451; rs5030068; rs822364; rs5030048; rs5030041; rs266724; rs5030090; rs5030108; rs5030074; rs2304452; rs5030037; rs5030026; rs5030001; rs5030082; rs5030049; rs3841557; rs1656909; rs5030042; rs1656926; rs5030079; rs5030035; rs1656911; rs1648711; rs2062632; rs822362; rs5030031; rs5030025; rs1656920; rs5030088; rs5030012; rs5030085; rs266725; rs5030075; rs5029981; rs3856930; rs1648714; rs5030102; rs5030017; rs5030064; rs5030066; rs5030065; rs5029976; rs5030003; rs4686439; rs5030029; rs5030046; rs5030038; rs5030009; rs5029997; rs4686799; rs2651641; rs1656908; rs5030061; rs5030014; rs5030115; rs5030086; rs1656919; rs1656916; rs5030016; rs5030060; rs5029982; rs5029989; rs5029996; rs5030047; rs5030093; rs5030058; rs5030070; rs5029993; rs1648699; rs5029977; rs5030067; rs1648713; rs2304455; rs5029998; rs5030091; rs266723; rs5030044; rs5030109; rs5030104; rs5030062; rs5030050; rs5030073; rs5029978; rs1656915; rs5030027; rs5030099; rs5029994; rs5030036; rs13317089; rs11917445; rs5030071; rs5030078; rs5030054; rs5030080; rs5030112; rs1523435; rs5029975; rs2304454; rs5029995; rs865880; rs5030101; rs5029983; rs5030105; rs5030056; rs5030034; rs5030019; rs5030008; rs266726; rs9869244; rs5030077; rs4686800; rs11929295; rs5030100; rs5030021; rs5030013; rs5030114; rs13084325; rs5030055; rs9882598; rs5030000; rs5030110; rs13098645; rs10440056; rs3774291; rs2651639; rs5029973; rs5029970; rs3806688; rs5029969; rs3774292; rs3821815; rs3806689; rs5029971; rs10439971; rs17838879; rs10440057; rs5029972; rs10439970; rs33934143; rs13072823; rs36121564; rs9866324; rs11328552; rs28461768; rs11276552; rs28607874; rs35578318; rs1212217; rs34098137; rs10571187; rs822365; rs35995617; rs10531727; rs11425592; rs11425593; rs35477316; rs35079146; rs34693243; rs13095338; rs1209472; rs34650598; rs13062473; rs28496811; rs13072436; rs35957661; rs10575985; rs13072694; rs34231414; rs9877452; rs10703695; rs10575988; rs10576660; rs34707597; rs34208952; rs35394339; rs11275829; rs11057; rs11328550; rs10662949; rs9818796; rs34957759; rs1656927; rs9825929; rs12635879; rs35569041; rs13063282; rs2912567; rs34651871; rs1211468; rs28390219; rs9819941; rs10575986; rs13095484; rs2304453; rs9851780; rs11328551; rs35025634; rs5030030; rs192371; rs13083619; rs35668151; rs35596301; rs13085884; rs13072546; rs9812764; rs11394050; rs3217421; rs13072563; rs35138120; rs34745532; rs13065593; rs10575987; rs35823469; rs34728507; rs35667207; rs10571591; rs35425194; rs2651642; rs35065127; rs3836479; rs10702686; rs11297934; rs1648717; rs36160200; rs10513803; rs10937264; rs10937265; rs10937266; rs11712801; rs11918289; rs11924390; rs11927941; rs12491806; rs12497377; rs12629364; rs13098570; rs13315296; rs1392952; rs1656939; rs1656940; rs1656966; rs1972703; rs2033122; rs266721; rs266722; rs266762; rs266763; rs266764; rs266767; rs34358682; rs35557208; rs35853604; rs4615069; rs4686436; rs5030097; rs5030098; rs6796803; rs6807774; rs7624355; rs7647509; rs822368; rs822370; rs822371; rs822373; rs905056; rs905057; rs961010; rs9817038; rs9838998; rs9852828

# Macromolecular_Interacting_Partner_1_General_References:
6441591; 2989293; 4054110; 4952632; 3484703; 3366244; 7589467; 2989294; 3182782; 12754519

# Macromolecular_Interacting_Partner_1_References:
1281379; 8904078; 9622142; 9638501

# Macromolecular_Interacting_Partner_2_ID:
7191

# Macromolecular_Interacting_Partner_2_Name:
Vasopressin-neurophysin 2-copeptin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
AVP-NPII[Contains: Arg-vasopressin; Neurophysin 2; Neurophysin-II; Copeptin]

# Macromolecular_Interacting_Partner_2_Gene_Name:
AVP

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Vasopressinneurophysin 2copeptin precursor
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCA
DELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGF
HRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
17325

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
4.94

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  neurohypophyseal hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00220:Hormone_4;
PF00184:Hormone_5

# Macromolecular_Interacting_Partner_2_Signals:
1-19

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
340303

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
NEU2_HUMAN (P01185)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
AVP

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
AVP

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:894

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>495 bp
ATGCCTGACACCATGCTGCCCGCCTGCTTCCCTGGCCTACTGGCCTTCTCCTCCGCGTGC
TACTTCCAGAACTGCCCGAGGGGCGGCAAGAGGGCCATGTCCGACCTGGAGCTGAGACAG
TGCCTCCCCTGCGGCCCCGGGGGCAAAGGCCGCTGCTTCGGGCCCAGCATCTGCTGCGCG
GACGAGCTGGGCTGCTTCGTGGGCACGGCTGAGGCGCTGCGCTGCCAGGAGGAGAACTAC
CTGCCGTCGCCCTGCCAGTCCGGCCAGAAGGCGTGCGGGAGCGGGGGCCGCTGCGCCGCC
TTCGGCGTTTGCTGCAACGACGAGAGCTGCGTGACCGAGCCCGAGTGCCGCGAGGGCTTT
CACCGCCGCGCCCGCGCCAGCGACCGGAGCAACGCCACGCAGCTGGACGGGCCGGCCGGG
GCCTTGCTGCTGCGGCTGGTGCAGCTGGCCGGGGCGCCCGAGCCCTTCGAGCCCGCCCAG
CCCGACGCCTACTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M11166

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_2_Locus:
20p13

# Macromolecular_Interacting_Partner_2_SNPs:
rs5195; rs2282018; rs3787482; rs2740204; rs2770381; rs2740185; rs6037481; rs3761249; rs3729965; rs6115785; rs1887854; rs11697831; rs1051744; rs28934878; rs13041277; rs13041150; rs13041148; rs3729964; rs1051747; rs13041122; rs1051748; rs1051746; rs6115784; rs2740190; rs11482923; rs13037218; rs4815565; rs34852810; rs7362057; rs2770380; rs1410713; rs2740188; rs2740207; rs2740208; rs2740210; rs2770378; rs4813627; rs6037478; rs6051572; rs6051578; rs6084265

# Macromolecular_Interacting_Partner_2_General_References:
2991279; 3768139; 4065330; 1740104; 11780052; 6574452; 7271787; 8370682; 8103767; 8514868; 8045958; 7714110; 8554046; 9360520; 9580132; 9814475; 10369876; 11017955; 11150885; 10677561; 11748489; 11161827; 11980620; 12012274; 12107248; 12359138; 12519420

# Macromolecular_Interacting_Partner_2_References:
12072411

# Macromolecular_Interacting_Partner_3_ID:
7197

# Macromolecular_Interacting_Partner_3_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_3_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_3_Signals:
1-26

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_3_Locus:
2p23.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_3_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_3_References:
10437805; 1322161; 1354078; 1531483

# Macromolecular_Interacting_Partner_4_ID:
7549

# Macromolecular_Interacting_Partner_4_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
INS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
INS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.5

# Macromolecular_Interacting_Partner_4_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_4_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_4_References:
1296859; 1481903; 15898729

# Macromolecular_Interacting_Partner_5_ID:
7556

# Macromolecular_Interacting_Partner_5_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_5_Signals:
1-18

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_5_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_5_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_5_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_5_References:
11244026; 2018930; 8039844

# Macromolecular_Interacting_Partner_6_ID:
5998

# Macromolecular_Interacting_Partner_6_Name:
Cytochrome P450 11A1, mitochondrial precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
CYPXIA1; P450(scc; Cholesterol side-chain cleavage enzyme; Cholesterol desmolase

# Macromolecular_Interacting_Partner_6_Gene_Name:
CYP11A1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Cytochrome P450 11A1, mitochondrial precursor
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60103

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.18

# Macromolecular_Interacting_Partner_6_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_6_Specific_Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone

# Macromolecular_Interacting_Partner_6_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_6_Reaction:
cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 1.14.15.6

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
181376

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CP11A_HUMAN (P05108)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CYP11A1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CYP11A1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:2590

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Mitochondrion

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1566 bp
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTACCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATGCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M14565

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_6_Locus:
15q23-q24

# Macromolecular_Interacting_Partner_6_SNPs:
rs6161; rs6160; rs4986873; rs2279357; rs1484215; rs11632698; rs11638442; rs12916123; rs4886594; rs1843090; rs6495096; rs41548820; rs7175214; rs2930299; rs41563614; rs41553712; rs17515476; rs12898858; rs12917295; rs2959021; rs41553612; rs41556119; rs7173655; rs7181332; rs900798; rs2073475; rs4887139; rs1049968; rs1130843; rs11544450; rs1130841; rs1132670; rs35048801; rs28671731; rs41543514; rs35153064; rs7177102; rs34371865; rs41556118; rs4887138; rs34304260; rs41543216; rs2930307; rs35856463; rs41546519; rs28681535; rs34637683; rs12442401; rs11350546; rs4640133; rs2959020; rs41550215; rs34223131; rs10635828; rs36133203; rs10644492; rs10645960; rs3831490; rs34886193; rs17522870; rs11633031; rs11635047; rs12438594; rs12899286; rs12899703; rs12900028; rs12917557; rs1564782; rs16968477; rs16968478; rs2170875; rs2277601; rs2277602; rs2277603; rs2277604; rs2277605; rs2277606; rs2279356; rs2930305; rs2930306; rs2959002; rs2959003; rs2959004; rs3803463; rs3825944; rs4077581; rs4077582; rs4077583; rs4077584; rs4077585; rs4278698; rs4432229; rs4886595; rs4887136; rs4887137; rs7163952; rs7164328; rs7174179; rs8031424; rs8034118; rs8039957; rs900802; rs9806234

# Macromolecular_Interacting_Partner_6_General_References:
3024157; 3038854; 1849407; 2419119; 10391209; 11502818; 12161514

# Macromolecular_Interacting_Partner_6_References:
2052554; 8243798

# Macromolecular_Interacting_Partner_7_ID:
7570

# Macromolecular_Interacting_Partner_7_Name:
Endothelin-1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Preproendothelin-1; PPET1[Contains: Endothelin-1; ET-1; Big endothelin-1]

# Macromolecular_Interacting_Partner_7_Gene_Name:
EDN1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Endothelin1 precursor
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
24425

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.92

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  interaction between organisms
Process:  interspecies interaction between organisms
Process:  symbiosis, encompassing mutualism through parasitism
Process:  pathogenesis
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of organismal physiological process
Process:  regulation of vasoconstriction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Endothelins are endothelium-derived vasoconstrictor peptides

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00322:Endothelin

# Macromolecular_Interacting_Partner_7_Signals:
1-17

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
31255

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
EDN1_HUMAN (P05305)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
EDN1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
EDN1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3176

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>639 bp
ATGGATTATTTGCTCATGATTTTCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAA
ACAGCAGTCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGAAACCCACT
CCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCTGCTCCTGCTCGTCCCTGATGGAT
AAAGAGTGTGTCTACTTCTGCCACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTT
GTTCCGTATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTACTTCCCACA
AAGGCAACAGACCGTGAGAATAGATGCCAATGTGCTAGCCAAAAAGACAAGAAGTGCTGG
AATTTTTGCCAAGCAGGAAAAGAACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAAT
AATCATAAGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATCAGCAGTTA
GTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAACACCTAAGACAAACCAGGTCGGAG
ACCATGAGAAACAGCGTCAAATCATCTTTTCATGATCCCAAGCTGAAAGGCAAGCCCTCC
AGAGAGCGTTATGTGACCCACAACCGAGCACATTGGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
Y00749

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p24.1

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
3282927; 2670930; 2659594; 8450044; 14574404; 2649896; 1864385; 9284755; 1515112; 7664037; 1859417; 1736987; 1422154; 7773179; 10231710; 10334806; 10391210

# Macromolecular_Interacting_Partner_7_References:
11430925; 11476758; 11566958; 12117304

# Macromolecular_Interacting_Partner_8_ID:
5766

# Macromolecular_Interacting_Partner_8_Name:
Kallikrein-1 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Tissue kallikrein; Kidney/pancreas/salivary gland kallikrein

# Macromolecular_Interacting_Partner_8_Gene_Name:
KLK1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Kallikrein1 precursor
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECEKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
262

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
28890

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.39

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Preferential cleavage of Arg-|- bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|- or Leu-|-. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-|- bonds [5]

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 3.4.21.35

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
186653

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
KLK1_HUMAN (P06870)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
KLK1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
KLK1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6357

# Macromolecular_Interacting_Partner_8_PDB_ID:
1SPJ

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>789 bp
ATGTGGTTCCTGGTTCTGTGCCTCGCCCTGTCCCTGGGGGGGACTGGTGCTGCGCCCCCG
ATTCAGTCCCGGATTGTGGGAGGCTGGGAGTGTGAGCAGCATTCCCAGCCCTGGCAGGCG
GCTCTGTACCATTTCAGCACTTTCCAGTGTGGGGGCATCCTGGTGCACCGCCAGTGGGTG
CTCACAGCTGCTCATTGCATCAGCGACAATTACCAGCTCTGGCTGGGTCGCCACAACTTG
TTTGACGACGAAAACACAGCCCAGTTTGTTCATGTCAGTGAGAGCTTCCCACACCCTGGC
TTCAACATGAGCCTCCTGGAGAACCACACCCGCCAAGCAGACGAGGACTACAGCCACGAC
CTCATGCTGCTCCGCCTGACAGAGCCTGCTGATACCATCACAGACGCTGTGAAGGTCGTG
GAGTTGCCCACCCAGGAACCCGAAGTGGGGAGCACCTGTTTGGCTTCCGGCTGGGGCAGC
ATCGAACCAGAGAATTTCTCATTTCCAGATGATCTCCAGTGTGTGGACCTCAAAATCCTG
CCTAATGATGAGTGCGAAAAAGCCCACGTCCAGAAGGTGACAGACTTCATGCTGTGTGTC
GGACACCTGGAAGGTGGCAAAGACACCTGTGTGGGTGATTCAGGGGGCCCGCTGATGTGT
GATGGTGTGCTCCAAGGTGTCACATCATGGGGCTACGTCCCTTGTGGCACCCCCAATAAG
CCTTCTGTCGCCGTCAGAGTGCTGTCTTATGTGAAGTGGATCGAGGACACCATAGCGGAG
AACTCCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M25629

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_8_Locus:
19q13.3

# Macromolecular_Interacting_Partner_8_SNPs:
rs5517; rs5515; rs5516; rs5518; rs3212857; rs1054713; rs2659058; rs2659103; rs3212820; rs3212819; rs3212836; rs3212828; rs3212817; rs3212833; rs3212835; rs3212837; rs2740502; rs3212834; rs3212830; rs3212829; rs3212825; rs3212821; rs2411330; rs2659104; rs3212827; rs2740505; rs3212832; rs3212856; rs3212826; rs3212822; rs3212831; rs2659101; rs2659099; rs3212849; rs3212845; rs3212850; rs2739454; rs2659100; rs2411334; rs5519; rs3212846; rs3212844; rs3212851; rs3212848; rs3212841; rs3212816; rs3212847; rs12052047; rs3212855; rs2739398; rs2659102; rs3212815; rs5514; rs17855377; rs34493997; rs2739397; rs3212818; rs2434452; rs3212824; rs2740504; rs34174355; rs34086786; rs3212823; rs35559244; rs2740503; rs35535011; rs10420205; rs3212839; rs34301743; rs34258064; rs36217621; rs34656187; rs4802746; rs35641597; rs34148425; rs35581737; rs35496131; rs10403329; rs10403407; rs10403612; rs10406287; rs10406403; rs10406640; rs10406695; rs10406721; rs10406908; rs10414120; rs10417605; rs10417831; rs10417989; rs10420039; rs11672844; rs11672950; rs11879167; rs11881755; rs12104176; rs12104311; rs12104424; rs16987576; rs171953; rs197589; rs2434451; rs2456584; rs2560934; rs2560935; rs2659056; rs2659097; rs266112; rs266114; rs266115; rs266116; rs266117; rs266850; rs266851; rs2739405; rs2739411; rs2739415; rs2739416; rs2739417; rs2739425; rs2739426; rs2739435; rs3212805; rs3212808; rs3212809; rs3212810; rs3212812; rs3212852; rs3212854; rs36062730; rs3745522; rs3745523; rs3909863; rs7246740; rs7247190; rs7252904; rs788887; rs788888; rs8100734; rs8100766; rs8100969; rs8101564; rs8104227

# Macromolecular_Interacting_Partner_8_General_References:
3004571; 2898948; 2686621; 3853975; 2666327; 3163150; 393608; 3635530

# Macromolecular_Interacting_Partner_8_References:
15886273; 1710605

# Macromolecular_Interacting_Partner_9_ID:
7620

# Macromolecular_Interacting_Partner_9_Name:
Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide 32

# Macromolecular_Interacting_Partner_9_Synonyms:
BNP-32]

# Macromolecular_Interacting_Partner_9_Gene_Name:
NPPB

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Natriuretic peptides B precursor Contains: Gammabrain natriuretic peptide; Brain natriuretic peptide 32
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE
QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRI
SSSSGLGCKVLRRH

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
134

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
14726

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
11.01

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_9_Signals:
1-26

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
179515

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
ANFB_HUMAN (P16860)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
NPPB

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
NPPB

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:7940

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>405 bp
ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCT
TTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACG
TCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAG
CAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGG
GAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCA
CCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATC
AGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M31776

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_9_Locus:
1p36.2

# Macromolecular_Interacting_Partner_9_SNPs:
rs5227; rs5229; rs35628673; rs5228; rs198389; rs198381; rs198388; rs6541007; rs3753581; rs198386; rs549596; rs198387; rs35640285; rs5230; rs35690395; rs13305989; rs35519114; rs35207557; rs35458601; rs3831247; rs34331786; rs13305990; rs616308; rs198380; rs12124640; rs13305991; rs35533748; rs12047640; rs12121986; rs12118667; rs35587340; rs1003632; rs1009591; rs1009592; rs1076626; rs11801879; rs11802855; rs11803049; rs12029160; rs12091159; rs12402363; rs12406089; rs12406383; rs12562819; rs12562952; rs12753716; rs1318408; rs13305986; rs17376426; rs1800773; rs198372; rs198373; rs198375; rs4846061; rs5063; rs5064; rs632793; rs6668352; rs6668659; rs6676300; rs6694164; rs6695740

# Macromolecular_Interacting_Partner_9_General_References:
2597152; 2522777; 2138890; 2136732

# Macromolecular_Interacting_Partner_9_References:
1531333; 2148083; 8849584

# Macromolecular_Interacting_Partner_10_ID:
7007

# Macromolecular_Interacting_Partner_10_Name:
Phosphatidylinositol 3-kinase regulatory subunit alpha

# Macromolecular_Interacting_Partner_10_Synonyms:
PI3-kinase p85-subunit alpha; PtdIns-3-kinase p85-alpha; PI3K

# Macromolecular_Interacting_Partner_10_Gene_Name:
PIK3R1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Phosphatidylinositol 3kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
724

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
83599

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.06

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  lipid kinase activity
Function:  phosphoinositide 3-kinase activity
Function:  phosphatidylinositol 3-kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  guanyl nucleotide binding
Function:  GTP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  GTPase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  protein complex
Component:  phosphoinositide 3-kinase complex

# Macromolecular_Interacting_Partner_10_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00620:RhoGAP;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
P85A_HUMAN (P27986)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
PIK3R1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
PIK3R1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:8979

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M61906

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_10_Locus:
5q13.1

# Macromolecular_Interacting_Partner_10_SNPs:
rs3730089; rs706713; rs3730090; rs3729981; rs7722222; rs3756668; rs2888323; rs3729984; rs12755; rs7702655; rs1131951; rs1043526; rs1643544; rs4016109; rs831125; rs171649; rs706714; rs251408; rs34303; rs2112208; rs895304; rs251409; rs251404; rs251399; rs1010793; rs10063119; rs2302976; rs2302975; rs6893676; rs3730082; rs34309; rs6861401; rs7733084; rs1664577; rs34301; rs10065413; rs831229; rs6876003; rs2302974; rs4122269; rs831123; rs10940160; rs10515070; rs173702; rs831122; rs6881033; rs7714169; rs3730086; rs17317833; rs3730087; rs10515074; rs6860081; rs16897511; rs3730088; rs12657050; rs7713645; rs7709243; rs6890202; rs42849; rs251402; rs6863431; rs34308; rs3815701; rs706716; rs40318; rs831121; rs3730078; rs10072475; rs1862162; rs6890176; rs12652661; rs34306; rs10515073; rs1445760; rs863818; rs1974781; rs1823023; rs17318918; rs173703; rs12659907; rs13156223; rs2161120; rs10940159; rs16897561; rs16897601; rs1819987; rs12697060; rs7716675; rs34304; rs4976156; rs16897558; rs11746842; rs12656176; rs251406; rs972634; rs1550805; rs7725370; rs173704; rs17839411; rs6863799; rs3730092; rs3730084; rs1862161; rs251410; rs6449960; rs7707370; rs994221; rs862714; rs11957103; rs2121109; rs2431166; rs10940158; rs7709991; rs6894871; rs831124; rs8192680; rs16897570; rs10940161; rs3730073; rs251405; rs16897562; rs28365970; rs6868872; rs251401; rs16897509; rs8192679; rs1946207; rs13173003; rs2431167; rs3730077; rs34300; rs34307; rs7713756; rs2121108; rs13167294; rs16897620; rs251407; rs1946208; rs3730091; rs17852841; rs34175949; rs17847317; rs10583550; rs1664558; rs41268435; rs9687541; rs17253369; rs2545411; rs7708232; rs10669997; rs1043425; rs10070142; rs34570857; rs5868531; rs7707793; rs3729983; rs35243561; rs34491401; rs7712540; rs10612198; rs10612201; rs7712126; rs5868532; rs7712114; rs34870423; rs35033772; rs33943986; rs10612200; rs2591417; rs2544847; rs1043426; rs1664560; rs34873643; rs1643545; rs9687422; rs36055833; rs9687539; rs1103100; rs1643543; rs34422073; rs3729982; rs35767695; rs34248986; rs13188418; rs251400; rs35255745; rs11285010; rs34010696; rs35510423; rs7717745; rs10577524; rs10614002; rs2591418; rs13154156; rs1611062; rs35472540; rs34305; rs6872284; rs1643556; rs11335573; rs1055643; rs9918196; rs10580592; rs861245; rs35373278; rs185179; rs34302; rs1643933; rs1643917; rs35582171; rs33965010; rs34287; rs36212686; rs11313149; rs185180; rs5868527; rs10552908; rs35213868; rs11343765; rs10579213; rs35812956; rs3049952; rs34037377; rs34027260; rs11351105; rs36121518; rs34476787; rs34330183; rs2545410; rs35893424; rs11291585; rs1819986; rs35728943; rs16897559; rs13180447; rs7732540; rs13153101; rs35800397; rs1300127; rs11349259; rs11334943; rs6872004; rs35918993; rs11308179; rs6871851; rs6872296; rs7735204; rs34157100; rs10461539; rs2591419; rs34695203; rs10036950; rs11960604; rs10611201; rs12153457; rs35508629; rs36029081; rs10055629; rs3730085; rs1643916; rs34594637; rs35918259; rs251403; rs11451948; rs35705146; rs10552907; rs10698662; rs5868528; rs7735075; rs1055644; rs34893631; rs34174926; rs34793287; rs34058255; rs5868529; rs4317277; rs11351869; rs34044740; rs11360241; rs10571324; rs862716; rs11280364; rs3730079; rs10678795; rs35929649; rs5024999; rs33968242; rs5868530; rs34063898; rs13163961; rs40056; rs35286739; rs35946831; rs34282574; rs36123886; rs13170618; rs34824771; rs34833428; rs6872690; rs10940157; rs11749932; rs11750202; rs40419; rs411751; rs450006; rs6449959; rs6872765; rs6899219; rs695166; rs706710; rs706711; rs706712; rs7701498; rs7701952; rs7723804; rs7732637; rs831227; rs9291926; rs9291927

# Macromolecular_Interacting_Partner_10_General_References:
1849461; 8628286; 7541045; 9489702; 9687533; 12359715; 12009866; 8648629; 8599763; 8962058; 11567151; 7681364; 8961927; 8670861; 9032108; 10768093

# Macromolecular_Interacting_Partner_10_References:
12629035

# Macromolecular_Interacting_Partner_11_ID:
6263

# Macromolecular_Interacting_Partner_11_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_11_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_11_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_11_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_11_Signals:
1-17

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_11_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_11_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_11_References:
12167602; 14637180; 15834289

# Macromolecular_Interacting_Partner_12_ID:
5977

# Macromolecular_Interacting_Partner_12_Name:
Adenylate cyclase type 7

# Macromolecular_Interacting_Partner_12_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Macromolecular_Interacting_Partner_12_Gene_Name:
ADCY7

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Macromolecular_Interacting_Partner_12_Number_of_Residues:
1080

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
120310

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_12_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Macromolecular_Interacting_Partner_12_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_12_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
40788941

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
ADCY7

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
ADCY7

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:238

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
D25538

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_12_Locus:
16q12-q13

# Macromolecular_Interacting_Partner_12_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Macromolecular_Interacting_Partner_12_General_References:
7584026

# Macromolecular_Interacting_Partner_12_References:
9798534

# Macromolecular_Interacting_Partner_13_ID:
7120

# Macromolecular_Interacting_Partner_13_Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
G gamma-I

# Macromolecular_Interacting_Partner_13_Gene_Name:
GNG2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Guanine nucleotidebinding protein GI/GS/GO gamma2 subunit precursor
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
FREKKFFCAIL

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
71

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
7850

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.22

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  extrinsic to membrane
Component:  extrinsic to plasma membrane
Component:  heterotrimeric G-protein complex

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00631:G-gamma

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
20147633

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
GBG2_HUMAN (P59768)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
GNG2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
GNG2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:4404

# Macromolecular_Interacting_Partner_13_PDB_ID:
1GP2

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>216 bp
ATGGCCAGCAACAACACCGCCAGCATAGCACAAGCCAGGAAGCTGGTAGAGCAGCTTAAG
ATGGAAGCCAATATCGACAGGATAAAGGTGTCCAAGGCAGCTGCAGATTTGATGGCCTAC
TGTGAAGCACATGCCAAGGAAGACCCCCTCCTGACCCCTGTTCCGGCTTCAGAAAACCCG
TTTAGGGAGAAGAAGTTTTTCTGTGCCATCCTTTAA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF493870

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_13_Locus:
14q21

# Macromolecular_Interacting_Partner_13_SNPs:
rs2173147; rs1540703; rs1057804; rs1890698; rs1953861; rs1253671; rs1253705; rs10150753; rs4898723; rs8008081; rs4271524; rs8014746; rs8017436; rs2357306; rs1618825; rs8006278; rs1959517; rs4271525; rs1253685; rs8019194; rs1253687; rs1693198; rs1253707; rs3204006; rs6572805; rs1253669; rs8014732; rs7153584; rs12883315; rs6572803; rs4901174; rs1253696; rs12883290; rs7158342; rs8019331; rs11157869; rs12435475; rs10131301; rs12889199; rs4898725; rs1253690; rs7154422; rs6572804; rs8011452; rs1253703; rs12435509; rs2000006; rs4901173; rs6572802; rs1253691; rs11621156; rs11851703; rs7160163; rs7154419; rs11157865; rs11623465; rs1253708; rs1253672; rs10143072; rs8020243; rs10498440; rs8015777; rs11623590; rs1253692; rs11157864; rs11623924; rs7152919; rs11624752; rs17124753; rs11625611; rs1959518; rs2357302; rs12434038; rs12894908; rs12882906; rs1874566; rs8019382; rs3742539; rs11621160; rs8007155; rs10498438; rs1343870; rs10498439; rs8010684; rs1953859; rs1253686; rs12147761; rs1890699; rs10129965; rs11157866; rs2357249; rs4901171; rs1623101; rs11624779; rs8009095; rs12588848; rs1693203; rs1253698; rs4514593; rs10133203; rs1253704; rs3742541; rs2275459; rs8009132; rs11622145; rs1253706; rs10146408; rs7143686; rs2357247; rs1253699; rs7150643; rs8010820; rs10147806; rs17124732; rs1253689; rs1253700; rs2357304; rs1269967; rs9635225; rs17124751; rs1953858; rs7148779; rs35277565; rs12588519; rs11625461; rs8003709; rs8009835; rs10147177; rs4901175; rs1253693; rs11628249; rs8009405; rs10144829; rs1693199; rs12880965; rs2357305; rs8014838; rs8005440; rs7143789; rs12890422; rs12100449; rs3818870; rs1316298; rs7494751; rs1578974; rs17124744; rs11621108; rs3742540; rs7144109; rs1253702; rs17252733; rs17124725; rs17124746; rs3742537; rs1109745; rs12101277; rs1253701; rs11850819; rs8010780; rs10220546; rs17124713; rs12895034; rs17124709; rs7153274; rs3204008; rs11847330; rs1253632; rs1262155; rs17092983; rs3825596; rs7143009; rs1253656; rs1693204; rs1253636; rs1253634; rs4898728; rs1032583; rs1032582; rs1253657; rs7141670; rs3825604; rs10873055; rs8019374; rs7147405; rs1253660; rs4633613; rs1253655; rs1253645; rs3825603; rs3825597; rs12431532; rs1253646; rs1253633; rs3825602; rs2236561; rs1253642; rs1032584; rs1253643; rs1253648; rs1253658; rs1253644; rs17124780; rs12432144; rs1253647; rs12436573; rs1271518; rs1253664; rs12433722; rs1253652; rs17124772; rs3825600; rs17124796; rs4898727; rs1253639; rs1497089; rs12431528; rs11850096; rs1253662; rs1253665; rs12433696; rs1253640; rs12894196; rs1272117; rs1253649; rs11847688; rs1253638; rs17124774; rs1253641; rs3825601; rs1693177; rs1253635; rs2236562; rs17124768; rs11157867; rs1253653; rs8019625; rs1253654; rs7144097; rs1253663; rs11847372; rs7159454; rs11157868; rs1253650; rs17831501; rs1253666; rs1253651; rs17124698; rs9743514; rs950010; rs12889322; rs36047102; rs36067357; rs35614601; rs4523850; rs35174771; rs35178030; rs35139612; rs12889284; rs7148451; rs35822692; rs12886703; rs35819066; rs35462757; rs10539775; rs35213821; rs35673554; rs17831464; rs8011560; rs17124735; rs35190987; rs34192983; rs2884152; rs35975919; rs28694719; rs1497081; rs36016212; rs10717240; rs34445110; rs11354444; rs35455303; rs36032151; rs7158119; rs4898724; rs34308582; rs34283228; rs5808640; rs8011272; rs34329964; rs35145745; rs34857364; rs1693193; rs12890418; rs34693198; rs12586590; rs10689259; rs35336316; rs11322637; rs11322270; rs34146466; rs35195529; rs35803539; rs4347544; rs2067829; rs11428089; rs1953860; rs17252712; rs5808641; rs34973942; rs11315945; rs34499635; rs33911162; rs35429944; rs35289455; rs7161446; rs28718093; rs8013372; rs1253688; rs2357303; rs34764790; rs7156066; rs10543520; rs34028168; rs11623464; rs1253694; rs10150861; rs34653407; rs35238426; rs35433627; rs35848969; rs1959516; rs12586607; rs35870554; rs28459525; rs35495615; rs10083534; rs10539774; rs35583464; rs35727674; rs35105434; rs12882099; rs33955770; rs12895248; rs11463019; rs1272118; rs1253695; rs34361665; rs1253697; rs12894239; rs8005542; rs34031930; rs35437257; rs35846208; rs35134680; rs36078788; rs34449528; rs28410474; rs12896633; rs35857266; rs35561589; rs35748925; rs34420705; rs3030340; rs35420086; rs12589934; rs35009719; rs36010201; rs34591914; rs1959519; rs34670484; rs11288986; rs34986921; rs35088349; rs12894231; rs35622909; rs34263394; rs34779533; rs4456417; rs8010602; rs10624821; rs34877164; rs33974701; rs4901172; rs34780909; rs34248762; rs4309306; rs34782634; rs5808639; rs8004034; rs35616481; rs5808645; rs34701338; rs34410329; rs17124728; rs34480788; rs35453948; rs12889304; rs9707478; rs35484737; rs10604942; rs35494600; rs3832939; rs36123684; rs35923674; rs35156219; rs4898726; rs35052096; rs35374258; rs34240079; rs34350221; rs28688492; rs35192783; rs35005802; rs34991244; rs34006183; rs10134518; rs10140188; rs2357248; rs1253673; rs5808642; rs2047364; rs34966733; rs1620540; rs34110528; rs17124723; rs33933786; rs6145342; rs33922275; rs34470726; rs5808643; rs2790507; rs35561836; rs35675957; rs1769485; rs34653524; rs35548218; rs1693171; rs4589468; rs35319859; rs35289575; rs1269018; rs11326387; rs11301975; rs1769484; rs34265134; rs10646775; rs10636640; rs11301974; rs1253637; rs1693172; rs10684028; rs1693202; rs28437731; rs11847369; rs3825598; rs28613476; rs10643481; rs34424623; rs34270098; rs5808644; rs17252747; rs1253659; rs35702479; rs33913949; rs35088804; rs1253661; rs35348536; rs1769486; rs34736340; rs11847426; rs17831409; rs35153814; rs10529707; rs10137625; rs10138800; rs10145910; rs10146660; rs10150721; rs10151155; rs11844663; rs11844741; rs12433790; rs12436400; rs12436887; rs12587228; rs12589956; rs12878101; rs12878420; rs12886319; rs1693194; rs1693195; rs17124691; rs17124692; rs17124695; rs17124696; rs17124815; rs17252644; rs1769483; rs2357245; rs2357246; rs34468044; rs34867128; rs4901170; rs7154813

# Macromolecular_Interacting_Partner_13_General_References:
10833460

# Macromolecular_Interacting_Partner_13_References:
8613234; 9798534

# Macromolecular_Interacting_Partner_14_ID:
7803

# Macromolecular_Interacting_Partner_14_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_14_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_14_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_14_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_14_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_14_SNPs:
Not Available

# Macromolecular_Interacting_Partner_14_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_14_References:
8713080

# Macromolecular_Interacting_Partner_15_ID:
8206

# Macromolecular_Interacting_Partner_15_Name:
Nitric-oxide synthase, endothelial

# Macromolecular_Interacting_Partner_15_Synonyms:
EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS

# Macromolecular_Interacting_Partner_15_Gene_Name:
NOS3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Nitricoxide synthase, endothelial
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
1203

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
133290

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

# Macromolecular_Interacting_Partner_15_Pathway:
map00330  Arginine and proline metabolism

# Macromolecular_Interacting_Partner_15_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 1.14.13.39

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
189212

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
NOS3_HUMAN (P29474)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
NOS3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
NOS3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:7876

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Cell membrane; caveola. Cytoplasm; cytoskeleton. Golgi apparatus. Note= Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>3612 bp
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
M93718

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_15_Locus:
7q36

# Macromolecular_Interacting_Partner_15_SNPs:
rs3918234; rs3918232; rs1799983; rs3918201; rs3918166; rs2566514; rs9282804; rs34967063; rs3918233; rs35281220; rs1549758; rs9282803; rs3918163; rs1800779; rs3918226; rs3918159; rs3918160; rs2243311; rs3918162; rs2070744; rs3918225; rs1800783; rs3918155; rs3918158; rs3918157; rs3918156; rs3918161; rs1808593; rs743507; rs1008140; rs3793341; rs3918196; rs3730002; rs3730003; rs3918188; rs2566511; rs891511; rs3918177; rs3730305; rs3730009; rs867225; rs3918182; rs1007311; rs3834873; rs2853792; rs3918192; rs3918227; rs3918175; rs3918171; rs1800782; rs3918187; rs2853795; rs3918205; rs3918176; rs3918202; rs1541861; rs3918178; rs753482; rs3918204; rs3793342; rs3918174; rs3918167; rs3730010; rs1800781; rs3918203; rs1800780; rs3918198; rs3918180; rs3918194; rs3918184; rs891512; rs3729625; rs743506; rs3918181; rs3918190; rs3918228; rs3918172; rs3918230; rs3918169; rs3918191; rs3730001; rs2853796; rs3918186; rs3918170; rs3918165; rs3918183; rs34919745; rs3730006; rs34372288; rs35795287; rs3918193; rs34554797; rs3918179; rs3918164; rs13305982; rs3918197; rs3918229; rs2243310; rs3918231; rs3918189; rs3918173; rs3918168; rs3918195; rs3918199; rs3918185; rs3918200; rs11771443; rs41377046; rs6947833; rs7792133; rs41508746; rs11552661; rs2566519; rs34417010; rs2566516; rs35886277; rs11371169; rs35480369; rs33915751; rs3730306; rs2566513; rs11974098; rs2566508; rs13305984; rs2566512; rs13311166; rs13310774; rs3730007; rs7776461; rs2853798; rs13305985; rs2853791; rs34110189; rs35771718; rs41385244; rs2853800; rs2566515; rs34833695; rs41490944; rs1799984; rs13310854; rs10539416; rs2566509; rs2566506; rs28763995; rs6969597; rs41322052; rs2853797; rs2853794; rs2566510; rs10539415; rs10255980; rs28763996; rs41408449; rs13310763; rs2566507; rs41394247; rs10595051; rs4725985; rs34617549; rs3828997; rs2853793; rs34204527; rs10531586; rs10265237; rs10276930; rs10277237; rs1064353; rs1077872; rs12666088; rs12703107; rs13307588; rs2373929; rs2373961; rs2373962; rs2566518; rs3134740; rs3730011; rs3730012; rs3800787; rs3918207; rs3918211; rs3918212; rs3918215; rs3918218; rs3918220; rs4496877; rs6951150; rs933163

# Macromolecular_Interacting_Partner_15_General_References:
1378832; 1379542; 7688726; 7509596; 7519987; 7514568; 7475956; 10074942; 12437348; 9737779

# Macromolecular_Interacting_Partner_15_References:
11430925; 12600921; 12697739; 14993198

# Macromolecular_Interacting_Partner_16_ID:
8405

# Macromolecular_Interacting_Partner_16_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_16_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_16_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_16_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_16_Locus:
Not Available

# Macromolecular_Interacting_Partner_16_SNPs:
Not Available

# Macromolecular_Interacting_Partner_16_General_References:
Not Available

# Macromolecular_Interacting_Partner_16_References:
10779123; 1319958; 1398892

# Macromolecular_Interacting_Partner_17_ID:
8123

# Macromolecular_Interacting_Partner_17_Name:
Renin precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
Angiotensinogenase

# Macromolecular_Interacting_Partner_17_Gene_Name:
REN

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Renin precursor
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
406

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
45058

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
7.07

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF07966:A1_Propeptide;
PF00026:Asp

# Macromolecular_Interacting_Partner_17_Signals:
1-23

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 3.4.23.15

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
190994

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
RENI_HUMAN (P00797)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
REN

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
REN

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:9958

# Macromolecular_Interacting_Partner_17_PDB_ID:
1BBS

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Secreted protein. Membrane. Note=Associated to membranes via binding to ATP6AP2

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1221 bp
ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT
ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC
TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG
AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC
TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA
GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC
TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC
AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG
GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG
CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA
CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA
GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA
CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC
CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC
TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT
TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT
TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC
AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG
CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC
CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT
GGCTTCGCCTTGGCCCGCTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
L00073

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_17_Locus:
1q32

# Macromolecular_Interacting_Partner_17_SNPs:
rs11571117; rs11571098; rs11571083; rs5705; rs11571120; rs11571124; rs7521667; rs2887284; rs1464816; rs1917539; rs6693954; rs5706; rs11571123; rs10900555; rs6676670; rs10900557; rs11571079; rs11240688; rs11571108; rs10900556; rs2368564; rs11571104; rs11571102; rs5707; rs11571078; rs11571107; rs11571114; rs11571091; rs11571119; rs11571082; rs11571088; rs11571077; rs11571105; rs11240686; rs11571106; rs3215332; rs3795574; rs11571092; rs11571111; rs3795575; rs11571112; rs2177695; rs3730102; rs11240689; rs11571086; rs6665480; rs11571113; rs3730104; rs11571084; rs3730103; rs11571118; rs11571100; rs11240687; rs11571087; rs2272237; rs6674952; rs11571110; rs11571085; rs11571103; rs11571101; rs11571121; rs11240685; rs11571109; rs11571080; rs11571076; rs11578877; rs11571081; rs11571115; rs11571090; rs6676458; rs11571122; rs11571116; rs6681776; rs6668858; rs6682082; rs11571096; rs11571073; rs11571075; rs11571097; rs11571074; rs11571093; rs11571128; rs11571126; rs11571095; rs11571094; rs11571127; rs11571125; rs6704321; rs11542630; rs34069565; rs1126947; rs1042875; rs5704; rs1042874; rs11799601; rs3730101; rs28580264; rs13306600; rs11284490; rs28730746; rs13306601; rs28417178; rs4439406; rs34296392; rs3839003; rs35241727; rs5708; rs4396166; rs35201130; rs34481638; rs11571099; rs11581713; rs28730747; rs2177694; rs10494849; rs1106778; rs16853059; rs16853062; rs16853072; rs1917542; rs1997034; rs2293337; rs3795576; rs6688425; rs6702587; rs7539596; rs7548714; rs940651; rs940652

# Macromolecular_Interacting_Partner_17_General_References:
6324167; 3530608; 6391881; 6138751; 3032746; 2540188; 3516796; 2016271; 12045255; 2493678; 1608447

# Macromolecular_Interacting_Partner_17_References:
10576144; 11244026; 12600921; 14517226

# Macromolecular_Interacting_Partner_18_ID:
8108

# Macromolecular_Interacting_Partner_18_Name:
Angiotensinogen precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
Serpin A8[Contains: Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Angiotensin-3; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II]

# Macromolecular_Interacting_Partner_18_Gene_Name:
AGT

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Angiotensinogen precursor
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
485

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
53155

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
6.27

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Angiotensin-3 stimulates aldosterone release

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_18_Signals:
1-33

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
178640

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ANGT_HUMAN (P01019)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
AGT

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
AGT

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:333

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1458 bp
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTGTCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
K02215

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q42-q43

# Macromolecular_Interacting_Partner_18_SNPs:
rs11568032; rs699; rs11568053; rs34829218; rs4762; rs11568041; rs2478522; rs5040; rs11568052; rs2004776; rs3789679; rs7539020; rs3789678; rs11568028; rs11568050; rs2493134; rs3889728; rs11568051; rs1078499; rs11568025; rs11568022; rs7539013; rs2148582; rs11568024; rs3827750; rs11568023; rs11568026; rs11122576; rs5050; rs5044; rs11568021; rs11568027; rs11568049; rs11568029; rs11122578; rs11568030; rs5051; rs4753; rs11122577; rs11568031; rs5043; rs5042; rs913147; rs1326883; rs5052; rs7079; rs2478539; rs2493132; rs2493129; rs3789671; rs1926722; rs11568055; rs10864772; rs11568044; rs3789669; rs11568036; rs11568034; rs3789664; rs11568040; rs3789666; rs11568045; rs2478543; rs2478545; rs6687360; rs1926723; rs2493133; rs11568039; rs2478544; rs2493131; rs11122575; rs11568054; rs3827749; rs11568056; rs2493130; rs3789677; rs11568038; rs11568042; rs2478523; rs11568035; rs11568037; rs3789670; rs3789667; rs11568043; rs3789672; rs11568033; rs7543316; rs10864771; rs10864770; rs943580; rs11568048; rs11568014; rs5046; rs6683321; rs7536290; rs2071404; rs5049; rs2067853; rs11568057; rs11568019; rs11568016; rs11122580; rs11122574; rs11568015; rs943581; rs2071406; rs2071405; rs2493136; rs11568018; rs11122573; rs5045; rs11568046; rs5048; rs2478524; rs5047; rs2493135; rs16852352; rs11568017; rs11568020; rs7533803; rs5039; rs1805090; rs5041; rs11557882; rs13306155; rs11557881; rs1803105; rs2229389; rs11557883; rs41271499; rs17856352; rs11557884; rs11557886; rs11557885; rs4029126; rs1803106; rs1803104; rs34099195; rs15022; rs1800585; rs1045464; rs11684; rs35680836; rs1803103; rs35832019; rs28730748; rs34041147; rs34069211; rs35937843; rs12125552; rs13306154; rs3789665; rs35832452; rs34924695; rs34433365; rs36218431; rs10545629; rs10593363; rs34758442; rs5781599; rs11445360; rs34933000; rs36218766; rs1051038; rs10864769; rs10864773; rs12042687; rs12059975; rs12083907; rs12723373; rs12746025; rs1326885; rs1326886; rs1410142; rs1410144; rs1854053; rs2296801; rs2478534; rs2493125; rs2493127; rs2493137; rs3789657; rs3789662; rs4028824; rs4284270; rs4628514; rs4846866; rs7524283; rs7549009; rs7555650; rs9804147

# Macromolecular_Interacting_Partner_18_General_References:
6089875; 2924688; 1692023; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; 1132082; 9492317; 1394429; 8513325; 7607642; 7744780; 8621667

# Macromolecular_Interacting_Partner_18_References:
10437805; 12544443; 1614061; 1676939

# Macromolecular_Interacting_Partner_19_ID:
8444

# Macromolecular_Interacting_Partner_19_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_19_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_19_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_19_Signals:
1-29

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_19_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_19_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_19_References:
11208696; 12464353

# Macromolecular_Interacting_Partner_20_ID:
8193

# Macromolecular_Interacting_Partner_20_Name:
Atrial natriuretic factor precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
ANF; Atrial natriuretic peptide; ANP; Prepronatriodilatin; CDD-ANF[Contains: Cardiodilatin-related peptide; CDP]

# Macromolecular_Interacting_Partner_20_Gene_Name:
NPPA

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Atrial natriuretic factor precursor
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
16708

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_20_Signals:
1-25

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
178630

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ANF_HUMAN (P01160)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
NPPA

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
NPPA

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:7939

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>456 bp
ATGAGCTCCTTCTCCACCACCACCGTGAGCTTCCTCCTTTTACTGGCATTCCAGCTCCTA
GGTCAGACCAGAGCTAATCCCATGTACAATGCCGTGTCCAACGCAGACCTGATGGATTTC
AAGAATTTGCTGGACCATTTGGAAGAAAAGATGCCTTTAGAAGATGAGGTCGTGCCCCCA
CAAGTGCTCAGTGAGCCGAATGAAGAAGCGGGGGCTGCTCTCAGCCCCCTCCCTGAGGTG
CCTCCCTGGACCGGGGAAGTCAGCCCAGCCCAGAGAGATGGAGGTGCCCTCGGGCGGGGC
CCCTGGGACTCCTCTGATCGATCTGCCCTCCTAAAAAGCAAGCTGAGGGCGCTGCTCACT
GCCCCTCGGAGCCTGCGGAGATCCAGCTGCTTCGGGGGCAGGATGGACAGGATTGGAGCC
CAGAGCGGACTGGGCTGTAACAGCTTCCGGTACTGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
K02043

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_20_Locus:
1p36.21

# Macromolecular_Interacting_Partner_20_SNPs:
rs5063; rs5065; rs5067; rs5066; rs5068; rs5064; rs198368; rs198367; rs198365; rs198369; rs198366; rs12744433; rs198364; rs198359; rs198358; rs17376426; rs198361; rs198357; rs7552330; rs198372; rs198360; rs198373; rs13305986; rs1803268; rs13305987; rs3170926; rs12565; rs1049827; rs11121835; rs198370; rs12744757; rs35427399; rs41300100; rs12723768; rs41275508; rs41307784; rs6695740; rs35183869; rs5772478; rs17037488; rs1003632; rs12024265; rs1023252; rs11802855; rs12029160; rs12047640; rs12091159; rs12567204; rs14078; rs169158; rs171983; rs17350396; rs198375; rs198381; rs198387; rs198388; rs198402; rs198403; rs198404; rs198405; rs198406; rs198408; rs198409; rs198410; rs198411; rs198412; rs198413; rs198414; rs198415; rs2075538; rs2075539; rs2272802; rs2272803; rs632793; rs6541007; rs6668352; rs6694164; rs7412854

# Macromolecular_Interacting_Partner_20_General_References:
6203042; 6547996; 6095118; 6095119; 6542248; 3158606; 6097248; 6238331; 6230082; 1826098; 8043577

# Macromolecular_Interacting_Partner_20_References:
10373213; 10614654; 12403658; 1649942

# Macromolecular_Interacting_Partner_21_ID:
8137

# Macromolecular_Interacting_Partner_21_Name:
Mineralocorticoid receptor

# Macromolecular_Interacting_Partner_21_Synonyms:
MR

# Macromolecular_Interacting_Partner_21_Gene_Name:
NR3C2

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Mineralocorticoid receptor
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
984

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
107068

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
7.42

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_21_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_21_Specific_Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
307166

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
MCR_HUMAN (P08235)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
NR3C2

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
NR3C2

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:7979

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>2955 bp
ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGT
CAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGGACCTACAGAGAGGACCGATGAGAAT
AACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT
CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGG
CCTGGGATTTTAACATCTGATATTAAAACTGAGCTGGAATCTAAGGAACTTTCAGCAACT
GTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG
CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTG
GTGAAATTTTACAAAGGAAATGGCCATCGTCCTTCCACTCTAAGTTGTGTGAACACGCCC
TTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCATT
GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATG
ACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTCTGTGTCCTCCACCACAGCCAGCTTT
GGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT
GCTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCT
CTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAATTTCCAGCCCTCCAAGTCACTGCAGT
GTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT
GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCC
ACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATCTATCTGTAGCCCTGTAAACAATGCC
TTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC
AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTA
GAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCTTAATATTGTCCAGTACATAAAACCA
GAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT
TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCT
TTTAAAGGGAATCCAACAGTAAACCCGTTTCCATTTATGGATGGCTCGTATTTTTCCTTT
ATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT
GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGACGGG
AGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGCTATTGTTGGGGTGAATTCAGGTGGA
CAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA
GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGG
AAATCACACGGCGACCTGTCGTCTAGAAGAAGTGATGGGTATCCGGTCTTAGAATACATT
CCAGAAAATGTATCAAGCTCTACTTTACGAAGTGTTTCTACTGGATCTTCAAGACCTTCA
AAAATATGTTTGGTGTGTGGGGATGAGGCTTCAGGATGCCATTATGGGGTAGTCACCTGT
GGCAGCTGCAAAGTTTTCTTCAAAAGAGCAGTGGAAGGGCAACACAACTATTTATGTGCT
GGAAGAAATGATTGCATCATTGATAAGATTCGACGAAAGAATTGTCCTGCTTGCAGACTT
CAGAAATGTCTTCAAGCTGGAATGAATTTAGGAGCACGAAAGTCAAAGAAGTTGGGAAAG
TTAAAAGGGATTCACGAGGAGCAGCCACAGCAGCAGCAGCCCCCACCCCCACCCCCACCC
CCGCAAAGCCCAGAGGAAGGGACAACGTACATCGCTCCTGCAAAAGAACCCTCGGTCAAC
ACAGCACTGGTTCCTCAGCTCTCCACAATCTCACGAGCGCTCACACCTTCCCCCGTTATG
GTCCTTGAAAACATTGAACCTGAAATTGTATATGCAGGCTATGACAGCTCAAAACCAGAT
ACAGCCGAAAATCTGCTCTCCACGCTCAACCGCTTAGCAGGCAAACAGATGATCCAAGTC
GTGAAGTGGGCAAAGGTACTTCCAGGATTTAAAAACTTGCCTCTTGAGGACCAAATTACC
CTAATCCAGTATTCTTGGATGTGTCTATCATCATTTGCCTTGAGCTGGAGATCGTACAAA
CATACGAACAGCCAATTTCTCTATTTTGCACCAGACCTAGTCTTTAATGAAGAGAAGATG
CATCAGTCTGCCATGTATGAACTATGCCAGGGGATGCACCAAATCAGCCTTCAGTTCGTT
CGACTGCAGCTCACCTTTGAAGAATACACCATCATGAAAGTTTTGCTGCTACTAAGCACA
ATTCCAAAGGATGGCCTCAAAAGCCAGGCTGCATTTGAAGAAATGAGGACAAATTACATC
AAAGAACTGAGGAAGATGGTAACTAAGTGTCCCAACAATTCTGGGCAGAGCTGGCAGAGG
TTCTACCAACTGACCAAGCTGCTGGACTCCATGCATGACCTGGTGAGCGACCTGCTGGAA
TTCTGCTTCTACACCTTCCGAGAGTCCCATGCGCTGAAGGTAGAGTTCCCCGCAATGCTG
GTGGAGATCATCAGCGACCAGCTGCCCAAGGTGGAGTCGGGGAACGCCAAGCCGCTCTAC
TTCCACCGGAAGTGA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
M16801

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_21_Locus:
4q31.1

# Macromolecular_Interacting_Partner_21_SNPs:
rs5522; rs5527; rs12509135; rs5523; rs13306592; rs5525; rs5529; rs5524; rs5528; rs2070949; rs2871; rs5534; rs7658048; rs5536; rs2070951; rs2070950; rs5530; rs17024360; rs6814934; rs5533; rs5535; rs5537; rs5532; rs6822758; rs1879828; rs1994624; rs1512327; rs1403142; rs1512341; rs1532890; rs1512342; rs2063009; rs1546529; rs1403143; rs907620; rs2137335; rs1546531; rs2137330; rs2163172; rs993386; rs1879829; rs6857487; rs7668847; rs3910047; rs4835514; rs1512329; rs3920217; rs4835479; rs6812904; rs6857011; rs6844155; rs6535594; rs1040288; rs6823544; rs2063556; rs878152; rs3846309; rs11724226; rs6840127; rs10012553; rs7693776; rs6840141; rs10032020; rs4835128; rs1913023; rs11723856; rs6848375; rs6844424; rs3910054; rs2883929; rs4835486; rs10026568; rs7695118; rs12649394; rs4835500; rs6535581; rs2884445; rs3846307; rs7438918; rs13133240; rs9993133; rs6820751; rs1512332; rs6535590; rs6856803; rs3857084; rs11099695; rs4835485; rs3752701; rs12499873; rs3910056; rs6810951; rs3843411; rs6850597; rs11736161; rs10857231; rs3843410; rs2356210; rs9997090; rs6811001; rs6535583; rs3846329; rs3846318; rs4835494; rs1512337; rs10010766; rs4835488; rs6832421; rs907618; rs2048546; rs1858416; rs6535599; rs4835478; rs2272089; rs3846319; rs879206; rs11099690; rs13133379; rs6847959; rs7677409; rs1818448; rs3846302; rs1512344; rs7661835; rs1879827; rs6831376; rs11099680; rs4835490; rs6535580; rs13105361; rs1355613; rs6535597; rs3846306; rs10434100; rs4027073; rs6856424; rs7665528; rs4635799; rs4835516; rs3846317; rs6535598; rs6832393; rs6535584; rs6815984; rs2293162; rs10011595; rs3846322; rs2063555; rs11929719; rs3910044; rs1512343; rs13103641; rs6535577; rs1490453; rs2048547; rs6820304; rs13116347; rs7696770; rs6535579; rs12512126; rs7670229; rs10023128; rs907619; rs6535602; rs4835519; rs3931397; rs2137334; rs7691663; rs6828665; rs2883930; rs907621; rs6825530; rs10519942; rs11099681; rs6828378; rs745019; rs17024708; rs11725509; rs13117325; rs1987969; rs3910052; rs11937655; rs12511893; rs12647605; rs6849127; rs6849903; rs12711259; rs6849862; rs3846316; rs11733930; rs6854515; rs17024387; rs17581884; rs6817983; rs6817925; rs7693171; rs12641471; rs6535588; rs11736713; rs4835133; rs13147775; rs6535593; rs10050229; rs10018805; rs17484259; rs3925570; rs4087964; rs3846328; rs1512326; rs4835508; rs10026226; rs4835506; rs12711260; rs6831034; rs13137823; rs12506077; rs2063554; rs3887856; rs7691250; rs11099679; rs17620160; rs7670069; rs12507494; rs17620330; rs16998733; rs4835491; rs6826213; rs7680420; rs745020; rs12506058; rs11945778; rs17024397; rs6846614; rs13116332; rs9996961; rs4513547; rs17620775; rs6535596; rs12651282; rs3916013; rs12498662; rs10021848; rs3846312; rs11734888; rs10519945; rs992556; rs9631756; rs17484454; rs12499208; rs17483854; rs6816503; rs10519959; rs10034789; rs3846305; rs10004472; rs4594704; rs4087965; rs4260521; rs1546044; rs12640639; rs7694064; rs12508913; rs17620822; rs2358243; rs13112423; rs3846325; rs6831887; rs10031992; rs7698302; rs10519952; rs10031538; rs7694706; rs17581311; rs6826471; rs11735947; rs6826594; rs3911846; rs3910046; rs13150372; rs10519955; rs7683540; rs7673644; rs13137836; rs1512330; rs4835493; rs10434130; rs12642178; rs4087963; rs7655438; rs1398269; rs11728254; rs6813167; rs7698307; rs4835504; rs17024456; rs2137331; rs4835482; rs17024654; rs13119790; rs2883917; rs11732490; rs2063553; rs3846320; rs17483391; rs6857716; rs7670173; rs11733686; rs4579099; rs1996025; rs3843413; rs3846301; rs17620105; rs9997336; rs6851669; rs4835131; rs17484357; rs11946576; rs10519951; rs3733421; rs7683313; rs6839414; rs17484671; rs3910051; rs10024999; rs11099692; rs17483979; rs6855032; rs4083100; rs10519963; rs17024482; rs2063557; rs13142954; rs7693077; rs4835138; rs6814226; rs10031194; rs1522451; rs13146357; rs17484873; rs3910053; rs6831212; rs11099678; rs3846326; rs12331321; rs6834935; rs6825048; rs6813869; rs11724292; rs6823323; rs11731398; rs10519954; rs17483833; rs9991002; rs3857079; rs10033040; rs10032250; rs6849817; rs4835484; rs7661326; rs1512331; rs4835503; rs10519958; rs4835483; rs6535600; rs3910057; rs3846321; rs17484678; rs11730274; rs13116524; rs11737660; rs13144030; rs6818452; rs7699349; rs6836191; rs1512335; rs2358336; rs17024443; rs11726964; rs3846299; rs1429915; rs7672951; rs4835136; rs17024479; rs10002896; rs17024514; rs1911120; rs2137332; rs10519962; rs13123626; rs4835497; rs2115800; rs10026826; rs6836072; rs11099677; rs17024718; rs17484783; rs13116099; rs12639977; rs7670121; rs6819635; rs17024666; rs17582206; rs11721992; rs10857232; rs11943992; rs10025629; rs11932750; rs12511415; rs6813390; rs3846300; rs12510074; rs13118475; rs17024611; rs17484811; rs17024683; rs17024380; rs3857083; rs11933180; rs17024408; rs4835512; rs12506066; rs17580772; rs6836246; rs17582031; rs11099688; rs11730626; rs17024706; rs6849327; rs9761994; rs3846313; rs17483701; rs17485033; rs7666711; rs11731400; rs9762822; rs6846738; rs17024633; rs9685254; rs6857339; rs17024541; rs13129830; rs3910058; rs7668671; rs11099686; rs12500487; rs7673925; rs765491; rs12499901; rs7686433; rs3910060; rs2172002; rs17581262; rs7690849; rs6833880; rs17024678; rs10034882; rs17581570; rs4560389; rs17484839; rs17024631; rs9994262; rs7698917; rs17581787; rs6816918; rs7687754; rs11736341; rs17484118; rs2137336; rs7694200; rs11099689; rs12647354; rs17024704; rs2137333; rs17484622; rs17581815; rs1964691; rs17484447; rs17484245; rs9995951; rs1398268; rs17024437; rs13146865; rs6822617; rs12502713; rs7665347; rs17024516; rs1512336; rs9994862; rs13148853; rs17007968; rs6843485; rs17484601; rs17024518; rs1429914; rs3846323; rs17581905; rs7698289; rs2883879; rs9685269; rs4091074; rs9760992; rs6850820; rs9683768; rs9685938; rs11099694; rs11931777; rs17024512; rs1512334; rs11939588; rs9761239; rs17581605; rs7700126; rs9992964; rs17024364; rs6829058; rs3846308; rs11729617; rs6535592; rs17024509; rs17024506; rs13137095; rs1858415; rs7442442; rs17024717; rs6840422; rs3846310; rs11932031; rs11722863; rs2056471; rs6858581; rs12504040; rs10026186; rs17581220; rs6535578; rs6841404; rs9990620; rs13133487; rs13109933; rs7690778; rs7689925; rs17621119; rs2356374; rs17024579; rs3857082; rs13150785; rs11099683; rs6846591; rs4835487; rs2048548; rs17024720; rs17024469; rs6832062; rs17581975; rs10034617; rs4835502; rs6846217; rs11721799; rs13108130; rs10012907; rs7688969; rs1512328; rs17024715; rs17024681; rs10857233; rs1877445; rs6854045; rs17484063; rs11099687; rs11099685; rs7682972; rs9685272; rs4835505; rs10010607; rs10033445; rs4301087; rs11931989; rs4835513; rs3846304; rs11732130; rs3910059; rs1033123; rs3910055; rs12508062; rs35644313; rs13118022; rs6855341; rs34861534; rs11727894; rs17580954; rs10001430; rs17024404; rs907617; rs17484991; rs7688209; rs12648444; rs17581996; rs12645409; rs1949169; rs6844150; rs6857670; rs11722067; rs3846315; rs13116551; rs17024560; rs11099696; rs7658039; rs11936376; rs878232; rs7698965; rs4835129; rs11725360; rs17024401; rs17024556; rs1980278; rs10009023; rs10434128; rs17376692; rs6856000; rs9995276; rs6841570; rs6842079; rs4835489; rs12509783; rs17676810; rs10519948; rs6853764; rs10011581; rs17581898; rs6851178; rs7690691; rs17581947; rs9998790; rs7692281; rs1522450; rs3857080; rs6854097; rs6846376; rs17483687; rs17024565; rs7674206; rs3910050; rs12506373; rs10029951; rs17581115; rs6812538; rs1873174; rs7696997; rs6836320; rs2301280; rs11936965; rs17024347; rs2248038; rs13306591; rs41511344; rs5526; rs34905604; rs5531; rs6848862; rs35832836; rs35396139; rs6823133; rs10708334; rs12643841; rs1062595; rs35360139; rs35586342; rs10028821; rs11292717; rs1062596; rs34293064; rs2070948; rs34347300; rs35771619; rs17580982; rs28549338; rs34802206; rs34026733; rs35713600; rs35258027; rs35789402; rs35606529; rs3054606; rs11730006; rs34476486; rs10562720; rs13138913; rs35132207; rs5862831; rs4505803; rs7668619; rs34734628; rs3910049; rs11939631; rs13144019; rs34471942; rs28647457; rs28594566; rs28656810; rs11384270; rs34886346; rs13139652; rs34030364; rs1946524; rs10021521; rs7699303; rs33936062; rs34054905; rs13149418; rs11381991; rs34431006; rs6815979; rs34953252; rs7674857; rs17580639; rs35590380; rs34165580; rs35135883; rs11940423; rs34244163; rs35978319; rs17024635; rs13112076; rs3887324; rs1512333; rs28672384; rs35224048; rs9993593; rs35237809; rs35378267; rs35436474; rs981372; rs3857081; rs13104218; rs5862829; rs35681362; rs13121960; rs34159127; rs3843414; rs9631755; rs36034042; rs5862838; rs7699209; rs35201774; rs36182734; rs35264279; rs11378484; rs35714983; rs35933180; rs35464072; rs35423790; rs28605213; rs11930469; rs35186171; rs1522449; rs11332546; rs10605309; rs6822304; rs9762356; rs6829009; rs4501202; rs35976575; rs2137338; rs11381917; rs1522452; rs9997290; rs35907005; rs35562931; rs11416123; rs13108703; rs34987101; rs34152444; rs34611880; rs35337326; rs34236655; rs35111299; rs3846330; rs28441385; rs7679518; rs33937448; rs3846303; rs35282722; rs35595748; rs17620469; rs28377603; rs35809828; rs4027074; rs6839408; rs11733477; rs5862833; rs34529215; rs35563216; rs17024667; rs34997890; rs34279352; rs4835515; rs35480965; rs3846327; rs11944891; rs2293163; rs33971837; rs28379421; rs35496556; rs34440852; rs6826827; rs28698626; rs6852036; rs35126311; rs35152746; rs28465033; rs11361774; rs36135256; rs1946523; rs10026777; rs7678106; rs35607293; rs2115798; rs35549271; rs7680091; rs34975695; rs7682465; rs35198554; rs13112089; rs34530174; rs10034839; rs34469488; rs10716270; rs28805917; rs35947630; rs4447838; rs4835501; rs28372032; rs7678425; rs35095537; rs6815139; rs28367185; rs3843412; rs35190729; rs34364416; rs35944210; rs35557372; rs4835137; rs1355612; rs6535591; rs10003237; rs1546530; rs7673832; rs35827730; rs11362297; rs34296798; rs35058866; rs35315376; rs33962250; rs28798239; rs34298854; rs28698266; rs11349017; rs34206536; rs2356394; rs11725517; rs13132072; rs7691775; rs13137655; rs34453040; rs28639664; rs13111594; rs36012041; rs34621287; rs13434549; rs11386119; rs33973334; rs28723458; rs35806661; rs11099682; rs13108682; rs11935760; rs28837820; rs13132300; rs6815356; rs17024561; rs3045289; rs35258207; rs35591475; rs28702892; rs35992616; rs36196281; rs28604902; rs34170216; rs13137039; rs34489084; rs4295241; rs6819902; rs34825669; rs28462077; rs36032097; rs4621409; rs10434129; rs11723538; rs12641579; rs35653840; rs11343039; rs926019; rs9997923; rs4122853; rs982076; rs13104030; rs35344401; rs12647673; rs13133177; rs35283376; rs35263055; rs6846848; rs6840172; rs28633715; rs6819706; rs35745299; rs34782286; rs5862834; rs5862828; rs7659754; rs7693371; rs35041849; rs6817070; rs12639699; rs34440621; rs36112050; rs34599173; rs28621626; rs11936509; rs10593353; rs35161508; rs35920138; rs3846311; rs35304305; rs34043561; rs28693507; rs4122851; rs28487903; rs13104472; rs9762359; rs35691150; rs13119744; rs11418057; rs34120297; rs11325949; rs965333; rs11326129; rs4026975; rs28869632; rs34643750; rs35003454; rs3846314; rs34966836; rs41510346; rs11444261; rs34113900; rs11303019; rs13138584; rs28482137; rs4027011; rs4293768; rs35554261; rs10528442; rs4835135; rs5862836; rs11459183; rs13118302; rs11440077; rs9992528; rs11323955; rs9654229; rs34090627; rs35633620; rs2102324; rs17304693; rs6838741; rs10586000; rs28789690; rs35476181; rs10654553; rs10624932; rs6833414; rs28645256; rs28834470; rs13132292; rs2358393; rs13139639; rs2358391; rs35101629; rs11724707; rs35649035; rs6831382; rs35957063; rs28367516; rs35414407; rs13105220; rs35574035; rs28408866; rs35013118; rs6535601; rs33924907; rs35672392; rs35706591; rs1033124; rs10023233; rs10025943; rs28377573; rs10650773; rs1911121; rs35087243; rs13104077; rs7670108; rs17024702; rs33913235; rs34874638; rs35954987; rs28663510; rs35637413; rs13120238; rs34771380; rs7678730; rs35697753; rs10008590; rs28593291; rs6535589; rs35210835; rs34273091; rs12507179; rs3053707; rs11363070; rs34012726; rs35945803; rs9993239; rs34416910; rs35504843; rs13145279; rs3927189; rs34311799; rs35146790; rs35181235; rs4835134; rs9992738; rs34374593; rs35318150; rs3752699; rs28588362; rs10607471; rs35749628; rs35992633; rs6854073; rs34815731; rs34799906; rs34810874; rs7668163; rs6535595; rs28711864; rs35264971; rs6814250; rs28369259; rs11940211; rs35083876; rs13144897; rs11320471; rs13127625; rs7438191; rs33955319; rs6148713; rs35899657; rs13129427; rs9994070; rs2137337; rs3910045; rs3045291; rs28408757; rs7375748; rs34408397; rs34019225; rs6852213; rs13136461; rs34980641; rs28802981; rs28542380; rs7661019; rs13132447; rs4835496; rs34189207; rs7685078; rs11365652; rs11947170; rs35303613; rs11324908; rs11731514; rs4613545; rs34201038; rs35227232; rs1039661; rs5862830; rs1913024; rs10019500; rs28886306; rs28505258; rs13123890; rs36193232; rs12650807; rs35870945; rs35700532; rs10050039; rs28376416; rs1057582; rs34880037; rs17024607; rs13149615; rs34890688; rs9994750; rs2884444; rs3857078; rs34704824; rs28648617; rs4122852; rs28612659; rs2356396; rs13104128; rs34636256; rs13136278; rs35441871; rs36048118; rs28657475; rs3846324; rs6823228; rs36084095; rs10857229; rs13107326; rs34499764; rs4027071; rs7670548; rs36145086; rs36150442; rs35832966; rs34625634; rs11330551; rs3041314; rs11363007; rs2115799; rs10648420; rs10008249; rs13142928; rs28464586; rs35591857; rs35550474; rs35903741; rs13146516; rs34946425; rs10564985; rs35545904; rs7377312; rs6854734; rs35593495; rs7668604; rs13119375; rs6818829; rs34936098; rs34272449; rs10434126; rs36036329; rs13112083; rs35000747; rs4611905; rs36084759; rs6827966; rs35940027; rs5862832; rs35659747; rs34400301; rs6831307; rs1512338; rs34618929; rs11324608; rs9999121; rs33928091; rs35667348; rs13109808; rs1506485; rs34896196; rs34217783; rs28407287; rs4835130; rs34576468; rs35162529; rs13133715; rs34220553; rs36127895; rs28368806; rs34718720; rs10593354; rs34580575; rs11727220; rs6854552; rs10026691; rs9995733; rs34168257; rs13115808; rs10608177; rs13134017; rs13103165; rs7438145; rs13106019; rs35504492; rs1512325; rs11384324; rs4560386; rs35925584; rs28696868; rs36041499; rs13137647; rs28897121; rs35642551; rs28507515; rs34868943; rs34430699; rs34051019; rs11722362; rs13132931; rs28622386; rs34346258; rs34696054; rs12511445; rs34317333; rs28391722; rs11386118; rs35741966; rs2356395; rs34642043; rs13109056; rs35311918; rs35979588; rs28529230; rs1429913; rs34163190; rs11335509; rs7656855; rs13104051; rs35367551; rs3045288; rs35932147; rs4835495; rs6839999; rs34372017; rs36114978; rs2358392; rs3906618; rs13125410; rs958785; rs13129690; rs4413384; rs36047772; rs35681147; rs995567; rs34623514; rs35762686; rs3902512; rs6846368; rs9993590; rs35118070; rs13139638; rs2037480; rs34918298; rs35694427; rs7682951; rs6852299; rs35541483; rs28851025; rs28498606; rs35070877; rs2356393; rs35820273; rs34948284; rs2174607; rs34358139; rs6841588; rs35325933; rs13133533; rs1398267; rs34152264; rs3910048; rs34438391; rs6840095; rs35756472; rs13114315; rs11377568; rs35022514; rs1512340; rs35079121; rs28500506; rs28398455; rs12331046; rs10542552; rs34209795; rs5862837; rs35441978; rs10012283; rs28696003; rs35542382; rs11726122; rs34294859; rs35115274; rs35534927; rs28770279; rs35338709; rs34927488; rs6854559; rs10034151; rs28452605; rs5862835; rs28848778; rs28607266; rs3216799; rs13306590; rs885859; rs34063900; rs6834026; rs7672177; rs34064829; rs885858; rs34022568; rs7671250; rs28742132; rs10689483; rs34706003; rs10213471; rs1039662; rs1039663; rs11099676; rs11728788; rs11933330; rs11933380; rs12499434; rs12641566; rs13111300; rs13141425; rs13148438; rs1490464; rs1490465; rs1546043; rs17024337; rs1907076; rs34158761; rs35815539; rs3884525; rs5521; rs6824449; rs7377816; rs906124; rs9307847; rs9724

# Macromolecular_Interacting_Partner_21_General_References:
3037703; 11518808; 9662404; 1655735; 7495694; 9141514; 9392437; 9724527; 10760050; 10935545; 11350956; 10391210; 11134129; 10884226; 12483305

# Macromolecular_Interacting_Partner_21_References:
11858800; 12852254; 12933324; 16393154

# Macromolecular_Interacting_Partner_22_ID:
8170

# Macromolecular_Interacting_Partner_22_Name:
Vascular cell adhesion protein 1 precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
V-CAM 1; CD106 antigen; INCAM-100

# Macromolecular_Interacting_Partner_22_Gene_Name:
VCAM1

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Vascular cell adhesion protein 1 precursor
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
739

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
81277

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF05790:C2-set;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_22_Signals:
1-24

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
699-720

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
179886

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
VCAM1_HUMAN (P19320)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
VCAM1

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
VCAM1

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:12663

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>1944 bp
ATGCCTGGGAAGATGGTCGTGATCCTTGGAGCCTCAAATATACTTTGGATAATGTTTGCA
GCTTCTCAAGCTTTTAAAATCGAGACCACCCCAGAATCTAGATATCTTGCTCAGATTGGT
GACTCCGTCTCATTGACTTGCAGCACCACAGGCTGTGAGTCCCCATTTTTCTCTTGGAGA
ACCCAGATAGATAGTCCACTGAATGGGAAGGTGACGAATGAGGGGACCACATCTACGCTG
ACAATGAATCCTGTTAGTTTTGGGAACGAACACTCTTACCTGTGCACAGCAACTTGTGAA
TCTAGGAAATTGGAAAAAGGAATCCAGGTGGAGATCTACTCTTTTCCTAAGGATCCAGAG
ATTCATTTGAGTGGCCCTCTGGAGGCTGGGAAGCCGATCACAGTCAAGTGTTCAGTTGCT
GATGTATACCCATTTGACAGGCTGGAGATAGACTTACTGAAAGGAGATCATCTCATGAAG
AGTCAGGAATTTCTGGAGGATGCAGACAGGAAGTCCCTGGAAACCAAGAGTTTGGAAGTA
ACCTTTACTCCTGTCATTGAGGATATTGGAAAAGTTCTTGTTTGCCGAGCTAAATTACAC
ATTGATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAAGAATTGCAAGTCTAC
ATATCACCCAAGAATACAGTTATTTCTGTGAATCCATCCACAAAGCTGCAAGAAGGTGGC
TCTGTGACCATGACCTGTTCCAGCGAGGGTCTACCAGCTCCAGAGATTTTCTGGAGTAAG
AAATTAGATAATGGGAATCTACAGCACCTTTCTGGAAATGCAACTCTCACCTTAATTGCT
ATGAGGATGGAAGATTCTGGAATTTATGTGTGTGAAGGAGTTAATTTGATTGGGAAAAAC
AGAAAAGAGGTGGAATTAATTGTTCAAGCATTCCCTAGAGATCCAGAAATCGAGATGAGT
GGTGGCCTCGTGAATGGGAGCTCTGTCACTGTAAGCTGCAAGGTTCCTAGCGTGTACCCC
CTTGACCGGCTGGAGATTGAATTACTTAAGGGGGAGACTATTCTGGAGAATATAGAGTTT
TTGGAGGATACGGATATGAAATCTCTAGAGAACAAAAGTTTGGAAATGACCTTCATCCCT
ACCATTGAAGATACTGGAAAAGCTCTTGTTTGTCAGGCTAAGTTACATATTGATGACATG
GAATTCGAACCCAAACAAAGGCAGAGTACGCAAACACTTTATGTCAATGTTGCCCCCAGA
GATACAACCGTCTTGGTCAGCCCTTCCTCCATCCTGGAGGAAGGCAGTTCTGTGAATATG
ACATGCTTGAGCCAGGGCTTTCCTGCTCCGAAAATCCTGTGGAGCAGGCAGCTCCCTAAC
GGGGAGCTACAGCCTCTTTCTGAGAATGCAACTCTCACCTTAATTTCTACAAAAATGGAA
GATTCTGGGGTTTATTTATGTGAAGGAATTAACCAGGCTGGAAGAAGCAGAAAGGAAGTG
GAATTAATTATCCAAGTTACTCCAAAAGACATAAAACTTACAGCTTTTCCTTCTGAGAGT
GTCAAAGAAGGAGACACTGTCATCATCTCTTGTACATGTGGAAATGTTCCAGAAACATGG
ATAATCCTGAAGAAAAAAGCGGAGACAGGAGACACAGTACTAAAATCTATAGATGGCGCC
TATACCATCCGAAAGGCCCAGTTGAAGGATGCGGGAGTATATGAATGTGAATCTAAAAAC
AAAGTTGGCTCACAATTAAGAAGTTTAACACTTGATGTTCAAGGAAGAGAAAACAACAAA
GACTATTTTTCTCCTGAGCTTCTCGTGCTCTATTTTGCATCCTCCTTAATAATACCTGCC
ATTGGAATGATAATTTACTTTGCAAGAAAAGCCAACATGAAGGGGTCATATAGTCTTGTA
GAAGCACAGAAATCAAAAGTGTAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
M30257

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_22_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_22_SNPs:
rs3783613; rs3783612; rs3783611; rs3783615; rs34100871; rs34228330; rs34199378; rs3176879; rs3176878; rs3783621; rs3783618; rs3783617; rs3783608; rs3783609; rs3783619; rs3783610; rs3783607; rs3176875; rs3176860; rs3176874; rs3176876; rs3917012; rs2392221; rs3181088; rs3765685; rs3819950; rs3917041; rs3176870; rs3917040; rs3176861; rs3917037; rs2209627; rs3176862; rs3917067; rs3176869; rs3917016; rs3917043; rs3917038; rs3917075; rs3917033; rs3917058; rs3917034; rs3917019; rs3917020; rs3917064; rs3917042; rs3176871; rs3176863; rs3917059; rs3917018; rs1476408; rs3176877; rs3917009; rs3917062; rs3176867; rs3917036; rs3181091; rs3917053; rs3181089; rs3917032; rs3917028; rs3917070; rs3917056; rs3917060; rs3917047; rs3917072; rs3917057; rs3917011; rs3917065; rs3917074; rs34186667; rs3917051; rs3176864; rs3917068; rs3917015; rs3917049; rs3917073; rs3917052; rs3917010; rs3176859; rs3917069; rs3917071; rs3917066; rs3917014; rs3176868; rs3917055; rs3917031; rs3917063; rs34599539; rs3917008; rs1041163; rs3181092; rs1409419; rs3917024; rs3181093; rs3170794; rs3181087; rs3783598; rs3783624; rs3783595; rs3783605; rs3917022; rs3917025; rs3783601; rs3783597; rs3917027; rs3917026; rs3783599; rs3783603; rs34708918; rs17123276; rs34682069; rs41287272; rs41402047; rs3194002; rs3783620; rs12740248; rs3917048; rs34736359; rs35831577; rs36046590; rs35811606; rs34871919; rs34681548; rs10680526; rs34203893; rs3917013; rs34484900; rs35625117; rs3176872; rs35904710; rs35377403; rs35668724; rs3917050; rs3917061; rs36115922; rs34602730; rs3917046; rs35885801; rs34934334; rs3917039; rs3917045; rs3181090; rs34552536; rs3917054; rs3917035; rs3917030; rs3176865; rs35026515; rs35742683; rs34768146; rs3917044; rs3917017; rs34577442; rs34037455; rs3917029; rs3783606; rs3783600; rs3917021; rs35200787; rs17109912; rs11420952; rs1800821; rs11302130; rs3834000; rs34900848; rs10493936; rs12080503; rs12129732; rs12240047; rs12403247; rs12409568; rs12732056; rs12747073; rs1571049; rs1582090; rs1582091; rs2050471; rs2094241; rs2209628; rs34853105; rs35964031; rs35978793; rs3917078; rs4520436; rs4584412; rs6660837; rs6680254

# Macromolecular_Interacting_Partner_22_General_References:
2688898; 1699207; 1707873; 1715583; 1379595; 1707234; 1377228; 7531291; 7539925

# Macromolecular_Interacting_Partner_22_References:
11834524

# Macromolecular_Interacting_Partner_23_ID:
8035

# Macromolecular_Interacting_Partner_23_Name:
Endothelin B receptor precursor

# Macromolecular_Interacting_Partner_23_Synonyms:
ET-B; Endothelin receptor Non- selective type

# Macromolecular_Interacting_Partner_23_Gene_Name:
EDNRB

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Endothelin B receptor precursor
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
442

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
49644

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
9.05

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  endothelin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_23_Signals:
1-26

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
102-126
138-163
176-197
219-243
272-296
325-350
363-389

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
182276

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
EDNRB_HUMAN (P24530)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
EDNRB

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
EDNRB

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:3180

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>1329 bp
ATGCAGCCGCCTCCAAGTCTGTGCGGACGCGCCCTGGTTGCGCTGGTTCTTGCCTGCGGC
CTGTCGCGGATCTGGGGAGAGGAGAGAGGCTTCCCGCCTGACAGGGCCACTCCGCTTTTG
CAAACCGCAGAGATAATGACGCCACCCACTAAGACCTTATGGCCCAAGGGTTCCAACGCC
AGTCTGGCGCGGTCGTTGGCACCTGCGGAGGTGCCTAAAGGAGACAGGACGGCAGGATCT
CCGCCACGCACCATCTCCCCTCCCCCGTGCCAAGGACCCATCGAGATCAAGGAGACTTTC
AAATACATCAACACGGTTGTGTCCTGCCTTGTGTTCGTGCTGGGGATCATCGGGAACTCC
ACACTTCTGAGAATTATCTACAAGAACAAGTGCATGCGAAACGGTCCCAATATCTTGATC
GCCAGCTTGGCTCTGGGAGACCTGCTGCACATCGTCATTGACATCCCTATCAATGTCTAC
AAGCTGCTGGCAGAGGACTGGCCATTTGGAGCTGAGATGTGTAAGCTGGTGCCTTTCATA
CAGAAAGCCTCCGTGGGAATCACTGTGCTGAGTCTATGTGCTCTGAGTATTGACAGATAT
CGAGCTGTTGCTTCTTGGAGTAGAATTAAAGGAATTGGGGTTCCAAAATGGACAGCAGTA
GAAATTGTTTTGATTTGGGTGGTCTCTGTGGTTCTGGCTGTCCCTGAAGCCATAGGTTTT
GATATAATTACGATGGACTACAAAGGAAGTTATCTGCGAATCTGCTTGCTTCATCCCGTT
CAGAAGACAGCTTTCATGCAGTTTTACAAGACAGCAAAAGATTGGTGGCTGTTCAGTTTC
TATTTCTGCTTGCCATTGGCCATCACTGCATTTTTTTATACACTAATGACCTGTGAAATG
TTGAGAAAGAAAAGTGGCATGCAGATTGCTTTAAATGATCACCTAAAGCAGAGACGGGAA
GTGGCCAAAACCGTCTTTTGCCTGGTCCTTGTCTTTGCCCTCTGCTGGCTTCCCCTTCAC
CTCAGCAGGATTCTGAAGCTCACTCTTTATAATCAGAATGATCCCAATAGATGTGAACTT
TTGAGCTTTCTGTTGGTATTGGACTATATTGGTATCAACATGGCTTCACTGAATTCCTGC
ATTAACCCAATTGCTCTGTATTTGGTGAGCAAAAGATTCAAAAACTGCTTTAAGTCATGC
TTATGCTGCTGGTGCCAGTCATTTGAAGAAAAACAGTCCTTGGAGGAAAAGCAGTCGTGC
TTAAAGTTCAAAGCTAATGATCACGGATATGACAACTTCCGTTCCAGTAATAAATACAGC
TCATCTTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
M74921

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_23_Locus:
13q22

# Macromolecular_Interacting_Partner_23_SNPs:
rs5352; rs1801710; rs2228271; rs5351; rs5349; rs5348; rs1537065; rs2329047; rs4884077; rs9544646; rs7333359; rs12585118; rs1537063; rs4884075; rs4885497; rs1924914; rs9544640; rs9544635; rs9574129; rs7997107; rs7332215; rs7326686; rs7333015; rs4885496; rs9318502; rs1854800; rs7330412; rs7323156; rs7317154; rs4885499; rs9544638; rs7328067; rs11618814; rs9574126; rs1924917; rs3027095; rs3759475; rs4283112; rs1924916; rs2329051; rs9565372; rs11838546; rs2070591; rs2068779; rs12720130; rs7326641; rs7324245; rs7324912; rs11149085; rs3027092; rs10507875; rs12716722; rs2329050; rs6563023; rs7333372; rs3027094; rs9544643; rs7325878; rs7358970; rs12720146; rs12720158; rs4275748; rs7319342; rs9574124; rs2181998; rs7339077; rs12720148; rs9574123; rs9544634; rs7332993; rs12720154; rs4884076; rs12720125; rs7329997; rs4885491; rs9544654; rs1537066; rs17068607; rs12720103; rs12720132; rs12720135; rs7491671; rs12720104; rs8000166; rs12720115; rs2329053; rs12720121; rs9544639; rs12720138; rs12720129; rs2329049; rs4474579; rs12720114; rs12720156; rs17068606; rs7323965; rs12720133; rs11839683; rs13378231; rs12720105; rs13378491; rs7998775; rs9544642; rs12720159; rs2876718; rs17068573; rs12720123; rs12720131; rs12720107; rs4884074; rs1951968; rs4366606; rs2329052; rs12720136; rs1924938; rs4885500; rs12720111; rs12720128; rs9544636; rs2329054; rs12720140; rs12720108; rs9544650; rs12720145; rs3759476; rs9600951; rs1537064; rs12720110; rs12720109; rs1924937; rs12720141; rs12720124; rs12720151; rs9574122; rs12720142; rs12720147; rs12720117; rs12720150; rs4242968; rs9600947; rs6563024; rs12720137; rs2329046; rs1886481; rs1886480; rs2147555; rs6563021; rs3818416; rs6563022; rs4885493; rs4885492; rs12720174; rs7990782; rs7333867; rs12720170; rs3027111; rs12720167; rs12720162; rs942612; rs12720199; rs11617203; rs3027110; rs12585038; rs7317759; rs2296281; rs9530703; rs942611; rs3027129; rs12720192; rs7982910; rs12720169; rs3027139; rs4884073; rs3027096; rs12720193; rs1924928; rs7325560; rs17068547; rs3027108; rs12720201; rs9600948; rs12720177; rs12720197; rs7333189; rs12720184; rs7318710; rs12720198; rs12720190; rs12720185; rs12720179; rs3027097; rs12720164; rs12720175; rs3027128; rs17068554; rs3027109; rs3027112; rs12720168; rs12720166; rs4435136; rs12720176; rs12720200; rs12720173; rs12720189; rs9544655; rs7335540; rs11149080; rs12720100; rs12720205; rs12720206; rs12584968; rs12720207; rs10467635; rs9544656; rs12720102; rs5345; rs5350; rs12720160; rs5347; rs3027103; rs5346; rs1050929; rs9565374; rs35546854; rs2209396; rs35299848; rs8000027; rs12720155; rs9544653; rs12720116; rs10709405; rs12868931; rs12720202; rs5804946; rs12720127; rs4476058; rs3039630; rs12720143; rs9544637; rs9530705; rs4587838; rs12720149; rs4884078; rs9530707; rs35723115; rs12583488; rs34186282; rs11436675; rs12872162; rs9544652; rs12872030; rs4884080; rs12720157; rs12427574; rs9530706; rs35338290; rs35040087; rs9544648; rs1050928; rs9544651; rs12720144; rs11841950; rs5804948; rs9544649; rs6145134; rs34546158; rs12868905; rs28645841; rs35032059; rs12720204; rs9600953; rs35767174; rs12720126; rs7338917; rs3039607; rs35499769; rs35264081; rs35604831; rs34344431; rs13378946; rs1924915; rs35014196; rs1050953; rs10570239; rs12720120; rs12868651; rs9574125; rs9565373; rs12859148; rs11840500; rs4884079; rs12720152; rs9544641; rs4315250; rs34372353; rs12720139; rs34733246; rs12720119; rs34917788; rs34847991; rs34055402; rs34739301; rs5804947; rs12720203; rs7989190; rs13378232; rs7986195; rs35844812; rs12868564; rs34835146; rs11841485; rs12720134; rs11838462; rs36126166; rs3027093; rs35743336; rs5804949; rs34053276; rs9544644; rs41288258; rs35048784; rs34484665; rs7317297; rs35162306; rs28494106; rs36111652; rs3039604; rs12100353; rs28886032; rs7989185; rs3027130; rs12720165; rs3027138; rs12720195; rs12720171; rs3027102; rs11620612; rs11617410; rs3027101; rs3027125; rs3027126; rs3027098; rs11359758; rs12720181; rs3027135; rs12720194; rs12876404; rs11841535; rs11617106; rs34407545; rs9574119; rs12720178; rs11617197; rs3027127; rs35680047; rs3027137; rs3027105; rs11388909; rs12720163; rs3027132; rs12720183; rs3027100; rs28470839; rs35249035; rs28690864; rs4553483; rs9634733; rs3027131; rs3027106; rs34576965; rs12720187; rs34601466; rs35358382; rs3027134; rs3027113; rs12720186; rs1134652; rs9544630; rs11619418; rs12720161; rs12720180; rs12720196; rs3027133; rs3027104; rs35088764; rs3027136; rs3179579; rs5804944; rs3027107; rs1801709; rs28622382; rs11620611; rs3027099; rs12720172; rs35899532; rs34914864; rs10587677; rs35332479; rs12720099; rs1924918; rs12720098; rs35151769; rs11618266; rs11840443; rs1330907; rs1335803; rs1335804; rs1924919; rs1924921; rs1924922; rs1924923; rs1924924; rs1924925; rs2876720; rs4591023; rs4885489; rs7318232; rs7333255; rs7983038; rs7994913; rs7998027; rs9544627; rs9544628; rs9544662; rs9593266; rs9600945

# Macromolecular_Interacting_Partner_23_General_References:
1710450; 1648908; 1291713; 8429023; 1713452; 8440682; 1282938; 10072757; 9284755; 9261180; 11891690; 9359036; 8001158; 8634719; 8852659; 8852660; 8630503; 9760196; 11471546; 12189494

# Macromolecular_Interacting_Partner_23_References:
10725252; 10756122; 11078344; 11094045

# Macromolecular_Interacting_Partner_24_ID:
7746

# Macromolecular_Interacting_Partner_24_Name:
Endothelin-1 receptor precursor

# Macromolecular_Interacting_Partner_24_Synonyms:
Endothelin A receptor; ET-A; hET- AR; ETA-R

# Macromolecular_Interacting_Partner_24_Gene_Name:
EDNRA

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Endothelin1 receptor precursor
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
427

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
48723

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
8.41

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  endothelin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is:ET1 > ET2 >> ET3

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_24_Signals:
1-20

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
81-102
113-132
160-181
206-229
257-278
307-328
348-372

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
238636

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
EDNRA_HUMAN (P25101)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
EDNRA

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
EDNRA

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:3179

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>1284 bp
ATGGAAACCCTTTGCCTCAGGGCATCCTTTTGGCTGGCACTGGTTGGATGTGTAATCAGT
GATAATCCTGAGAGATACAGCACAAATCTAAGCAATCATGTGGATGATTTCACCACTTTT
CGTGGCACAGAGCTCAGCTTCCTGGTTACCACTCATCAACCCACTAATTTGGTCCTACCC
AGCAATGGCTCAATGCACAACTATTGCCCACAGCAGACTAAAATTACTTCAGCTTTCAAA
TACATTAACACTGTGATATCTTGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACT
CTGCTCAGGATCATTTACCAGAACAAATGTATGAGGAATGGCCCCAACGCGCTGATAGCC
AGTCTTGCCCTTGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG
CTGCTGGCTGGGCGCTGGCCTTTTGATCACAATGACTTTGGCGTATTTCTTTGCAAGCTG
TTCCCCTTTTTGCAGAAGTCCTCGGTGGGGATCACCGTCCTCAACCTCTGCGCTCTTAGT
GTTGACAGGTACAGAGCAGTTGCCTCCTGGAGTCGTGTTCAGGGAATTGGGATTCCTTTG
GTAACTGCCATTGAAATTGTCTCCATCTGGATCCTGTCCTTTATCCTGGCCATTCCTGAA
GCGATTGGCTTCGTCATGGTACCCTTTGAATATAGGGGTGAACAGCATAAAACCTGTATG
CTCAATGCCACATCAAAATTCATGGAGTTCTACCAAGATGTAAAGGACTGGTGGCTCTTC
GGGTTCTATTTCTGTATGCCCTTGGTGTGCACTGCGATCTTCTACACCCTCATGACTTGT
GAGATGTTGAACAGAAGGAATGGCAGCTTGAGAATTGCCCTCAGTGAACATCTTAAGCAG
CGTCGAGAAGTGGCAAAAACAGTTTTCTGCTTGGTTGTAATTTTTGCTCTTTGCTGGTTC
CCTCTTCATTTAAGCCGTATATTGAAGAAAACTGTGTATAACGAGATGGACAAGAACCGA
TGTGAATTACTTAGTTTCTTACTGCTCATGGATTACATCGGTATTAACTTGGCAACCATG
AATTCATGTATAAACCCCATAGCTCTGTATTTTGTGAGCAAGAAATTTAAAAATTGTTTC
CAGTCATGCCTCTGCTGCTGCTGTTACCAGTCCAAAAGTCTGATGACCTCGGTCCCCATG
AACGGAACAAGCATCCAGTGGAAGAACCACGATCAAAACAACCACAACACAGACCGGAGC
AGCCATAAGGACAGCATGAACTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
S63938

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_24_Locus:
4q31.23

# Macromolecular_Interacting_Partner_24_SNPs:
rs5333; rs5334; rs2292764; rs5335; rs984457; rs5342; rs9308218; rs1356349; rs984458; rs5341; rs1801708; rs4835083; rs5340; rs10305851; rs10305862; rs5344; rs6855875; rs10305848; rs5336; rs5339; rs10305865; rs4835084; rs5862805; rs5343; rs10305937; rs10305866; rs10305859; rs10305849; rs5337; rs5338; rs10305935; rs11267091; rs10305852; rs10305931; rs10305938; rs10305936; rs10305932; rs10305853; rs10305860; rs2884340; rs1400556; rs1517135; rs2884337; rs952402; rs1878404; rs1996373; rs2048894; rs1996374; rs9308221; rs10029799; rs9884319; rs7655892; rs10008744; rs3814415; rs6840375; rs13143677; rs6812093; rs6840756; rs7655670; rs6827096; rs7674137; rs11933442; rs1568136; rs6841799; rs6537489; rs1517134; rs9308220; rs9307838; rs6822565; rs908581; rs7690347; rs2292765; rs9999853; rs6854578; rs6823537; rs10028507; rs7663891; rs7666105; rs702757; rs10003447; rs7677315; rs9308219; rs10305929; rs11939191; rs10305884; rs17612742; rs11946376; rs2357924; rs6855898; rs3942348; rs17474816; rs10305912; rs10010949; rs6848108; rs9997823; rs10011966; rs10305889; rs10305925; rs16998721; rs6537487; rs10305928; rs11940834; rs10031628; rs10305895; rs4639051; rs11946826; rs17023373; rs10305917; rs10024834; rs10305883; rs10305921; rs4835410; rs11942855; rs17023371; rs7684766; rs17474823; rs3756022; rs6821368; rs4835412; rs10028666; rs10011035; rs11938394; rs10305880; rs6843446; rs7681275; rs10305926; rs4835086; rs10305927; rs6841473; rs6831737; rs10305920; rs10305875; rs9307837; rs17675063; rs10305863; rs10305886; rs10305899; rs10305892; rs10305922; rs17023360; rs11935436; rs10020557; rs10305909; rs1400554; rs10305914; rs10305888; rs17023396; rs10305923; rs2884339; rs10305907; rs10305915; rs10305871; rs10305881; rs11937200; rs11938973; rs10305876; rs17023363; rs10305906; rs4591581; rs10305913; rs11942620; rs10305898; rs10305919; rs10017079; rs10305908; rs13306320; rs10305869; rs10305916; rs10305879; rs10305910; rs11830; rs10305896; rs10305885; rs11936340; rs10305918; rs11934092; rs10305894; rs2884341; rs4563479; rs10305870; rs10011234; rs13435440; rs6842241; rs10305840; rs1800786; rs6841581; rs10305845; rs10305838; rs10305844; rs10305842; rs10305839; rs10305846; rs17852056; rs17856671; rs17856670; rs10305868; rs10305867; rs17852057; rs13306317; rs11724088; rs10305861; rs11552087; rs35309925; rs35184992; rs10305930; rs10305856; rs3190169; rs34136788; rs10305854; rs35542356; rs35063997; rs13306318; rs10305933; rs33954623; rs3216163; rs10305857; rs10305858; rs36124688; rs1049963; rs10305855; rs11930745; rs35678177; rs10305934; rs34375765; rs36077037; rs13306316; rs2292766; rs3068757; rs9993718; rs34466950; rs11726398; rs10305903; rs35088870; rs13125865; rs35757953; rs13121996; rs10305905; rs1517133; rs34531381; rs4455398; rs35630078; rs34246155; rs35826351; rs10305890; rs34533330; rs33912823; rs34015008; rs10570878; rs17023496; rs4419459; rs13121537; rs34890988; rs10692988; rs10305882; rs10551607; rs4835411; rs34079253; rs10305878; rs10305902; rs34962702; rs10305873; rs35796687; rs7660300; rs28839485; rs33985171; rs34658974; rs35034877; rs13136385; rs13121745; rs33954106; rs10305900; rs13113405; rs11940520; rs34965226; rs7437031; rs11337911; rs33958974; rs34229972; rs2357925; rs34519684; rs10305874; rs17023427; rs34270975; rs36207078; rs35961327; rs10305904; rs36023655; rs10546909; rs10024734; rs1400555; rs10305891; rs35374177; rs35106938; rs35299479; rs6818686; rs4321614; rs35151309; rs33946964; rs10305924; rs10305901; rs10305864; rs28477369; rs34887339; rs35080290; rs10012917; rs36064870; rs11464046; rs10305911; rs11732422; rs34635238; rs10305897; rs11321422; rs11405111; rs7439670; rs34291358; rs34276058; rs28551143; rs11330586; rs2229305; rs13107867; rs35774514; rs10019230; rs5862803; rs11286891; rs35139018; rs34322422; rs28572568; rs35495016; rs10003944; rs34450591; rs35461850; rs13434817; rs4456941; rs9884495; rs2357923; rs4590003; rs2884338; rs36041517; rs13142627; rs10608985; rs34437454; rs35822305; rs10305877; rs35452559; rs35932664; rs10642617; rs10305893; rs13306319; rs10305887; rs11424571; rs10305847; rs10305841; rs10305843; rs35891036; rs35349287; rs34300379; rs10028838; rs10305940; rs10305942; rs10305943; rs11734418; rs11737131; rs11942203; rs11942234; rs12650382; rs1400557; rs1568137; rs1878406; rs4333164; rs6537483; rs6537484; rs6537485; rs6811707; rs6819740; rs6823732; rs6833588; rs7657903; rs7673178; rs7684691; rs7684717; rs7684882; rs7685896; rs7685925; rs7686338; rs9307839; rs9307840; rs9884563; rs9991584

# Macromolecular_Interacting_Partner_24_General_References:
1719979; 1659806; 1652463; 1291713; 8440682; 1326535; 1415318; 8611157; 8427579; 9284755; 11262386

# Macromolecular_Interacting_Partner_24_References:
10523363

# Macromolecular_Interacting_Partner_25_ID:
8159

# Macromolecular_Interacting_Partner_25_Name:
5-hydroxytryptamine 2A receptor

# Macromolecular_Interacting_Partner_25_Synonyms:
5-HT-2A; Serotonin receptor 2A; 5- HT-2

# Macromolecular_Interacting_Partner_25_Gene_Name:
HTR2A

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>5hydroxytryptamine 2A receptor
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
471

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
52604

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.72

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
76-99
111-132
148-171
192-215
234-254
325-346
363-384

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
36431

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
5HT2A_HUMAN (P28223)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
HTR2A

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
HTR2A

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:5293

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Note=Localizes to the post-synaptic thickening of axo-dendritic synapses (By similarity)

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>1416 bp
ATGGATATTCTTTGTGAAGAAAATACTTCTTTGAGCTCAACTACGAACTCCCTAATGCAA
TTAAATGATGACACCAGGCTCTACAGTAATGACTTTAACTCTGGAGAAGCTAACACTTCT
GATGCATTTAACTGGACAGTCGACTCTGAAAATCGAACCAACCTTTCCTGTGAAGGGTGC
CTCTCACCGTCGTGTCTCTCCTTACTTCATCTCCAGGAAAAAAACTGGTCTGCTTTACTG
ACAGCCGTAGTGATTATTCTAACTATTGCTGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTTGCCATAGCTGAT
ATGCTGCTGGGTTTCCTTGTCATGCCCGTGTCCATGTTAACCATCCTGTATGGGTACCGG
TGGCCTCTGCCGAGCAAGCTTTGTGCAGTCTGGATTTACCTGGACGTGCTCTTCTCCACG
GCCTCCATCATGCACCTCTGCGCCATCTCGCTGGACCGCTACGTCGCCATCCAGAATCCC
ATCCACCACAGCCGCTTCAACTCCAGAACTAAGGCATTTCTGAAAATCATTGCTGTTTGG
ACCATATCAGTAGGTATATCCATGCCAATACCAGTCTTTGGGCTACAGGACGATTCGAAG
GTCTTTAAGGAGGGGAGTTGCTTACTCGCCGATGATAACTTTGTCCTGATCGGCTCTTTT
GTGTCATTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTAACTATCAAGTCA
CTCCAGAAAGAAGCTACTTTGTGTGTAAGTGATCTTGGCACACGGGCCAAATTAGCTTCT
TTCAGCTTCCTCCCTCAGAGTTCTTTGTCTTCAGAAAAGCTCTTCCAGCGGTCGATCCAT
AGGGAGCCAGGGTCCTACACAGGCAGGAGGACTATGCAGTCCATCAGCAATGAGCAAAAG
GCATGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCTTTCTTC
ATCACAAACATCATGGCCGTCATCTGCAAAGAGTCCTGCAATGAGGATGTCATTGGGGCC
CTGCTCAATGTGTTTGTTTGGATCGGTTATCTCTCTTCAGCAGTCAACCCACTAGTCTAC
ACACTGTTCAACAAGACCTATAGGTCAGCCTTTTCACGGTATATTCAGTGTCAGTACAAG
GAAAACAAAAAACCATTGCAGTTAATTTTAGTGAACACAATACCGGCTTTGGCCTACAAG
TCTAGCCAACTTCAAATGGGACAAAAAAAGAATTCAAAGCAAGATGCCAAGACAACAGAT
AATGACTGCTCAATGGTTGCTCTAGGAAAGCAGCATTCTGAAGAGGCTTCTAAAGACAAT
AGCGACGGAGTGAATGAAAAGGTGAGCTGTGTGTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
X57830

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_25_Locus:
13q14-q21

# Macromolecular_Interacting_Partner_25_SNPs:
rs1805055; rs6304; rs6308; rs6314; rs6313; rs6305; rs35480504; rs3803189; rs3125; rs17069218; rs2296973; rs1923888; rs1745837; rs643627; rs2770295; rs1002513; rs1923882; rs1923884; rs1928038; rs977003; rs1928040; rs633737; rs2770298; rs1885884; rs1923887; rs2760351; rs4942578; rs9534506; rs1928042; rs4941574; rs6561334; rs1033847; rs985934; rs9567739; rs4942587; rs2070036; rs9534511; rs2070039; rs9534493; rs9316232; rs927544; rs6561336; rs4941571; rs594242; rs9567737; rs985933; rs9534507; rs582385; rs659734; rs972979; rs4941573; rs7322347; rs582854; rs7324343; rs6561335; rs2274639; rs731779; rs9567735; rs9534509; rs2770300; rs4942582; rs17069089; rs2025296; rs2246127; rs9526238; rs1928041; rs11841433; rs622337; rs9534505; rs4941570; rs9316235; rs2070040; rs7330636; rs1328684; rs12584920; rs9526240; rs1923885; rs666693; rs2770296; rs4942583; rs7984966; rs2070037; rs9562686; rs655888; rs6561332; rs655854; rs2770302; rs9567746; rs1328683; rs7330461; rs9526246; rs1923886; rs17288723; rs2770293; rs9316233; rs2296972; rs1928039; rs9526245; rs2770304; rs2770297; rs7994746; rs1328674; rs632903; rs1410657; rs3742279; rs2224721; rs2770294; rs621494; rs912127; rs9534495; rs17359763; rs12876614; rs2760346; rs7322422; rs9567744; rs2770299; rs9534502; rs9526241; rs7332753; rs17287961; rs9526239; rs9567743; rs3945573; rs2760344; rs2760349; rs658101; rs17068986; rs7322420; rs7326071; rs7986766; rs9562687; rs731778; rs9316236; rs689099; rs677702; rs11617142; rs2760345; rs4942584; rs17360184; rs2016711; rs2760350; rs619549; rs1885882; rs9567747; rs1328677; rs7981633; rs2770292; rs1328675; rs17069020; rs3742278; rs7328886; rs7997012; rs4942585; rs2760348; rs9534496; rs1928043; rs7323792; rs9562689; rs7338257; rs9534503; rs17069035; rs9534508; rs9567745; rs7330368; rs9567736; rs4090088; rs9562685; rs17069005; rs9534510; rs9316234; rs2070035; rs9670454; rs9534504; rs9534501; rs9562688; rs2760347; rs7323079; rs7985321; rs1475196; rs1328685; rs6312; rs7324218; rs6310; rs6316; rs6311; rs7325168; rs17289304; rs7324017; rs7323441; rs7325200; rs7997977; rs7996679; rs7325801; rs7323693; rs6315; rs7324942; rs6306; rs6309; rs6317; rs9595552; rs2230948; rs6307; rs1058576; rs35224115; rs1058573; rs35942462; rs34073547; rs28461499; rs34600609; rs35222525; rs11619524; rs9562684; rs34067369; rs34546983; rs34735457; rs34191502; rs35044667; rs5803378; rs34023544; rs34389615; rs1923883; rs11444567; rs1885883; rs34156927; rs35600514; rs7317640; rs4942586; rs34265171; rs28439202; rs9567748; rs36032976; rs7322128; rs34450267; rs35735410; rs41306666; rs4942579; rs5803377; rs2770301; rs34116107; rs9534497; rs34758371; rs9567734; rs2760340; rs2146672; rs4942580; rs11148017; rs2405864; rs9567742; rs2183056; rs35774769; rs1923889; rs2770303; rs9526237; rs35990864; rs4941572; rs35157208; rs9567740; rs660358; rs2760339; rs9567738; rs33974073; rs2760343; rs11394720; rs34188313; rs2760342; rs7491120; rs35031636; rs7490923; rs17069045; rs35265991; rs2405863; rs11381663; rs10666389; rs35136640; rs12862862; rs34420017; rs10675250; rs1328676; rs688590; rs626318; rs4536360; rs10562734; rs9595553; rs35906144; rs10648117; rs34493167; rs2070038; rs5803379; rs41284193; rs2760341; rs7992607; rs35166479; rs35805696; rs33913126; rs35656598; rs1125644; rs13306426; rs36212791; rs1125643; rs36212451; rs36212784; rs36212792; rs35865007; rs36212789; rs36213156; rs1048952; rs34720476; rs10507544; rs12017281; rs12863574; rs17069137; rs17289394; rs2149433; rs2149434; rs4142900; rs4286023; rs4387507; rs4389056; rs4389057; rs4389058; rs4575433; rs4941575; rs4942588; rs6561333; rs731244; rs731245; rs732821; rs7328833; rs7329640; rs7330190; rs7330205; rs7333412; rs7490304; rs9534490; rs9534491; rs9534512; rs9534513; rs9534514; rs9534515; rs9567731; rs9567732; rs9567733; rs9590997; rs9595546; rs9595549; rs9595550; rs9595551

# Macromolecular_Interacting_Partner_25_General_References:
1722404; 1323014; 8035173; 1330647; 11150294; 8655141; 10581480; 10391209

# Macromolecular_Interacting_Partner_25_References:
16014306

# Macromolecular_Interacting_Partner_26_ID:
7872

# Macromolecular_Interacting_Partner_26_Name:
5-hydroxytryptamine 2B receptor

# Macromolecular_Interacting_Partner_26_Synonyms:
5-HT-2B; Serotonin receptor 2B

# Macromolecular_Interacting_Partner_26_Gene_Name:
HTR2B

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>5hydroxytryptamine 2B receptor
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
481

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
54299

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
9.47

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_26_General_Function:
Not Available

# Macromolecular_Interacting_Partner_26_Specific_Function:
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
57-79
92-113
130-151
172-192
217-239
325-345
361-383

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
475198

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
5HT2B_HUMAN (P41595)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
HTR2B

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
HTR2B

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:5294

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>1446 bp
ATGGCTCTCTCTTACAGAGTGTCTGAACTTCAAAGCACAATTCCTGAGCACATTTTGCAG
AGCACCTTTGTTCACGTTATCTCTTCTAACTGGTCTGGATTACAGACAGAATCAATACCA
GAGGAAATGAAACAGATTGTTGAGGAACAGGGAAATAAACTGCACTGGGCAGCTCTTCTG
ATACTCATGGTGATAATACCCACAATTGGTGGAAATACCCTTGTTATTCTGGCTGTTTCA
CTGGAGAAGAAGCTGCAGTATGCTACTAATTACTTTCTAATGTCCTTGGCGGTGGCTGAT
TTGCTGGTTGGATTGTTTGTGATGCCAATTGCCCTCTTGACAATAATGTTTGAGGCTATG
TGGCCCCTCCCACTTGTTCTATGTCCTGCCTGGTTATTTCTTGACGTTCTCTTTTCAACC
GCATCCATCATGCATCTCTGTGCCATTTCAGTGGATCGTTACATAGCCATCAAAAAGCCA
ATCCAGGCCAATCAATATAACTCACGGGCTACAGCATTCATCAAGATTACAGTGGTGTGG
TTAATTTCAATAGGCATTGCCATTCCAGTCCCTATTAAAGGGATAGAGACTGATGTGGAC
AACCCAAACAATATCACTTGTGTGCTGACAAAGGAACGTTTTGGCGATTTCATGCTCTTT
GGCTCACTGGCTGCCTTCTTCACACCTCTTGCAATTATGATTGTCACCTACTTTCTCACT
ATCCATGCTTTACAGAAGAAGGCTTACTTAGTCAAAAACAAGCCACCTCAACGCCTAACA
TGGTTGACTGTGTCTACAGTTTTCCAAAGGGATGAAACACCTTGCTCGTCACCGGAAAAG
GTGGCAATGCTGGATGGTTCTCGAAAGGACAAGGCTCTGCCCAACTCAGGTGATGAAACA
CTTATGCGAAGAACATCCACAATTGGGAAAAAGTCAGTGCAGACCATTTCCAACGAACAG
AGAGCCTCAAAGGTCCTAGGGATTGTGTTTTTCCTCTTTTTGCTTATGTGGTGTCCCTTC
TTTATTACAAATATAACTTTAGTTTTATGTGATTCCTGTAACCAAACTACTCTCCAAATG
CTCCTGGAGATATTTGTGTGGATAGGCTATGTTTCCTCAGGAGTGAATCCTTTGGTCTAC
ACCCTCTTCAATAAGACATTTCGGGATGCATTTGGCCGATATATCACCTGCAATTACCGG
GCCACAAAGTCAGTAAAAACTCTCAGAAAACGCTCCAGTAAGATCTACTTCCGGAATCCA
ATGGCAGAGAACTCTAAGTTTTTCAAGAAACATGGAATTCGAAATGGGATTAACCCTGCC
ATGTACCAGAGTCCAATGAGGCTCCGAAGTTCAACCATTCAGTCTTCATCAATCATTCTA
CTAGATACGCTTCTCCTCACTGAAAATGAAGGTGACAAAACTGAAGAGCAAGTTAGTTAT
GTATAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
X77307

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_26_Locus:
2q36.3-q37.1

# Macromolecular_Interacting_Partner_26_SNPs:
Not Available

# Macromolecular_Interacting_Partner_26_General_References:
8143856; 7926008; 8078486; 10722792; 11150294

# Macromolecular_Interacting_Partner_26_References:
8627522

# Macromolecular_Interacting_Partner_27_ID:
8202

# Macromolecular_Interacting_Partner_27_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_27_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_27_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_27_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_27_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_27_Locus:
10q22

# Macromolecular_Interacting_Partner_27_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_27_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_27_References:
11208696; 12623949

End of HMDB00016

Beginning of HMDB00017
# Accession_No:
HMDB00017

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-24 15:59:56

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
4-Pyridoxic acid

# Description:
The catabolic product of VITAMIN B6 (pyridoxine, pyridoxal and pyradoxamine) which is excreted in the urine. Urine levels of 4-pyridoxic acid are lower in females than in males and will be reduced in persons with riboflavin deficiency. 

# Synonyms:
2-Methyl-3-hydroxy-4-carboxy-5-hydroxymethylpyridine; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylate; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylic acid; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinate; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinic acid; 3-Hydroxy-5-hydroxymethyl-2-methyl-isonicotinsaeure; 3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinate; 3-hydroxy-5-(hydroxymethyl)-2-methyl-Isonicotinic acid; 3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinate; 3-hydroxy-5-hydroxymethyl-2-methyl-isonicotinic acid; 4-Pyridoxate; 4-Pyridoxinate; 4-Pyridoxinecarboxylate; 4-Pyridoxinecarboxylic acid; 4-Pyridoxinic acid; 4-Pyridoxinsaeure; 4-Pyridoxylate; 4-Pyridoxylic acid

# Chemical_IUPAC_Name:
3-hydroxy-5-(hydroxymethyl)-2-methyl-pyridine-4-carboxylic acid

# Chemical_Formula:
C8H9NO4

# Chemical_Structure:
tbl_chemical:::HMDB00017_ZOOM.png:::119283131002915442

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00017_THUMB.png:::11928313080691496

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; phenol or hydroxyhetarene; carboxylic acid; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
183.05316

# Molecular_Weight_Avg:
183.16136

# Smiles_String_isomeric:
CC1=NC=C(CO)C(C(O)=O)=C1O

# Smiles_String_canonical:
CC1=NC=C(CO)C(C(O)=O)=C1O

# KEGG_Compound_ID:
C00847

# BioCyc_ID:
CPD-1112

# PubChem_CID:
6723

# PubChem_SID:
149703; 96540; 8154358; 8144151; 7591946; 3884996; 4104; 10428690

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
36190

# Wikipedia_ID:
Not Available

# METLIN_ID:
239

# Ref_ID:
12001008; 8279138; 15447904; 15975484; 16054880; 1742549; 16277678; 15450810; 12638029; 15976101; 12368406

# ChEBI_ID:
17405

# CAS_Registry_Number:
82-82-6

# InChI:
InChI=1/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)

# Synthesis_Reference:
Huff, J.W. et al., J. Biol. Chem., 1944, 155, 345-355; Japan. Pat., 1992, 04 95 074 CA, 117, 90051d

# Melting_Point:
247-248 oC

# Melting_Point_predicted:
110.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
53.0 mg/mL [MEYLAN,WM et al. (1996)]; 8.72 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.07 [Predicted by ALOGPS]; 0.1 [Predicted by PubChem via XLOGP]; -0.07 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::4-Pyridoxic_acid.mol:::1132723801437701829

# SDF_File_[Text]:
tbl_chemical:::HMDB00017.sdf:::119283130420487761

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00017.pdb:::119283130639547582

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::00017_Pyridoxic_acid.zip:::118236134393642128

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050126_P00_10_IS_assigned.png:::118236134395715221

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050126_P00_10_IS_2DHSQC_1419.png:::116248599192417548

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050126_P00_10_IS_2DHSQC_1419.zip:::116248599196244168

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::Pyridoxic acid(HMDB00017).png:::116248599217446161

# Predicted_H_NMR_Spectrum:
tbl_chemical:::4-Pyridoxic acid.gif:::1132732098968680247

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00017_peaks.txt:::1156309487243422876

# Predicted_C_NMR_Spectrum:
tbl_chemical:::4-Pyridoxic acid_C.gif:::1132737657587448565

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00017_peaks.txt:::1156310679242715956

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Bladder; Erythrocyte; Kidney; Liver

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	12.52 +/- 6.53	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12001008
Urine	> 3.0	umol/L	Children:1-13_yrs_old	Both	Normal	12368406
Blood	0.040 +/- 0.007	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bladder Cancer; Vitamin B6 Deficiency

# Pathway_Names:
Valine, leucine and isoleucine degradation;Vitamin B6 metabolism;Nicotinate and nicotinamide metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;;Nicotinamide_synthesis_(NADH).jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00750;map00760;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;;Nicotinamide_synthesis_(NADH).xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5358

# Metabolic_Enzyme_1_Name:
Aldehyde oxidase

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
AOX1

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde oxidase
MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTPYGCGGGGCGACTVMISRYN
PITKRIRHHPANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPG
MVMSIYPLLRNHPEPTLDQLTDALGGNLCRCHGYRPIIDACKTFCKTSGCCQSKENGVCC
LDQGINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMADKQSQRTRVFGSER
MMWFSPVTLKDLLEFKFKYPQAPVIMGNTSVGPEVKFKGVFHPGYNSPDRIEEPECCKPC
IYGLTLGAGLSLAQVKDILADVVQKLPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHII
SRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPISR
KWEFVSAFRQAQRQENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKL
IGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVSQILKKMDPV
HYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYC
DDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAE
KFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTIEESIQHNSSFKPE
RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKY
IQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGE
DMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF
PNLRCRGWACRTNLPSNTAFRGFGFPQAVLITESCITEVAAKCGLSPEKVRIINMYKEID
QTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLAS
RAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETV
PNANISGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVG
YFRGYESDMNWEKGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAID
IGQIEGAFIQGMGLYTIEELNYSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSN
TLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGPLTLNSPLTPEKIRMACEDKFT
KMIPRDEPGSYVPWNVPI

# Metabolic_Enzyme_1_Number_of_Residues:
1338

# Metabolic_Enzyme_1_Molecular_Weight:
147933

# Metabolic_Enzyme_1_Theoretical_pI:
7.11

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2)

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00350  Tyrosine metabolism;
 map00380  Tryptophan metabolism;
 map00750  Vitamin B6 metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + H2O + O2 = a carboxylic acid + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01315:Ald_Xan_dh_C;
PF02738:Ald_Xan_dh_C2;
PF03450:CO_deh_flav_C;
PF00941:FAD_binding_5;
PF00111:Fer2;
PF01799:Fer2_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.3.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
438656

# Metabolic_Enzyme_1_SwissProt_ID:
ADO_HUMAN (Q06278)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AOX1

# Metabolic_Enzyme_1_Geneatlas_id:
AOX1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:553

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>4017 bp
ATGGACCGGGCGTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGATAGAAAAAAAT
GTCGATCCTGAAACAATGCTGTTGCCTTATTTGAGGAAGAAGCTTCGACTCACAGGAACT
CCGTATGGCTGTGGAGGAGGAGGCTGTGGTGCTTGTACAGTGATGATATCACGATACAAC
CCCATCACCAAGAGGATAAGGCATCACCCAGCCAATGCCTGTCTGATTCCCATCTGTTCT
CTGTATGGTGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCCACACCAGAATTCAT
CCTGTTCAGGAGAGGATTGCCAAGTGTCATGGCACCCAGTGTGGCTTCTGCACACCTGGG
ATGGTGATGTCCATCTACCCCCTGCTCAGGAACCACCCAGAGCCCACTCTGGATCAGTTA
ACTGATGCCCTTGGTGGTAACCTGTGCCGTTGCCATGGATACAGGCCCATAATTGATGCA
TGCAAGACTTTCTGTAAAACTTCGGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT
TTGGATCAAGGAATCAATGGATTGCCAGAATTTGAGGAAGGAAGTAAGACAAGTCCAAAA
CTCTTCGCAGAAGAGGAGTTTCTGCCATTGGATCCAACCCAGGAACTGATATTTCCTCCT
GAGCTAATGATAATGGCTGATAAACAGTCGCAAAGGACCAGGGTGTTTGGCAGTGAGAGA
ATGATGTGGTTTTCCCCCGTGACCCTGAAGGACCTGCTGGAATTTAAATTCAAGTATCCC
CAGGCTCCTGTTATCATGGGAAACACCTCTGTGGGGCCTGAAGTGAAATTTAAAGGCGTC
TTTCACCCAGGTTATAATTCTCCTGATAGAATTGAAGAACCTGAGTGTTGTAAACCATGC
ATATATGGACTCACCCTTGGTGCTGGTCTCAGCCTAGCCCAGGTGAAGGACATTTTGGCT
GATGTAGTCCAGAAGCTTCCAGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAGCAT
TTGGGAACTCTGGCTGGGTCCCAGATCAGGAACATGGCTTCTTTAGGGGGACACATCATT
AGCAGGCATCCAGATTCAGATCTGAATCCCATCCTGGCTGTGGGTAACTGTACCCTCAAC
TTGCTATCAAAAGAAGGAAAACGACAGATTCCTTTAAATGAGCAATTCCTCAGCAAGTGC
CCTAATGCAGATCTTAAGCCTCAAGAAATCTTGGTCTCAGTGAACATCCCCATCTCAAGG
AAGTGGGAATTTGTGTCAGCCTTCCGACAAGCCCAGCGACAGGAGAATGCGCTAGCGATA
GTCAATTCAGGAATGAGAGTCTTTTTTGGAGAAGGGGATGGCATTATTAGAGAGTTATGC
ATCTCATATGGAGGCGTTGGTCCAGCCACCATCTGTGCCAAGAATTCCTGCCAGAAACTC
ATTGGAAGGCACTGGAACGAACAGATGCTGGATATAGCCTGCAGGCTTATTCTGAATGAA
GTCTCCCTTTTGGGCTCGGCGCCAGGTGGGAAAGTGGAGTTCAAGAGGACTCTCATCATC
AGCTTCCTCTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAAAAGATGGATCCAGTT
CACTATCCTAGCCTTGCAGACAAGTATGAAAGTGCTTTAGAAGATCTTCATTCCAAACAT
CACTGCAGTACATTAAAGTACCAGAATATAGGCCCAAAGCAGCATCCTGAAGACCCAATT
GGCCACCCCATCATGCATCTGTCTGGTGTGAAGCATGCCACGGGGGAGGCCATCTACTGT
GATGACATGCCTCTGGTGGACCAGGAACTTTTCTTGACTTTTGTGACTAGTTCAAGAGCT
CATGCTAAGATTGTGTCTATTGATCTGTCAGAAGCTCTCAGCATGCCCGGTGTGGTGGAC
ATCATGACAGCAGAACATCTTAGTGACGTCAACTCCTTCTGCTTTTTTACTGAAGCTGAG
AAATTTCTGGCGACAGATAAGGTGTTCTGTGTGGGTCAGCTTGTCTGTGCTGTGCTTGCC
GATTCTGAGGTTCAGGCAAAGCGAGCTGCTAAGCGAGTGAAGATTGTCTATCAAGACTTG
GAGCCGCTGATACTAACAATTGAGGAAAGTATACAACACAACTCCTCCTTCAAGCCAGAA
AGGAAACTGGAATATGGAAATGTTGACGAAGCATTTAAAGTGGTTGATCAAATTCTTGAA
GGTGAAATACATATGGGAGGTCAAGAACATTTTTATATGGAAACCCAAAGCATGCTTGTC
GTTCCCAAGGGAGAGGATCAAGAAATGGATGTCTACGTGTCCACACAGTTTCCCAAATAT
ATACAGGACATTGTTGCCTCAACCTTGAAGCTCCCAGCTAACAAGGTCATGTGCCATGTA
AGGCGTGTTGGTGGAGCGTTTGGAGGGAAGGTGTTAAAAACCGGAATCATTGCAGCCGTC
ACTGCATTTGCCGCAAACAAACATGGCCGTGCAGTTCGCTGTGTTCTGGAACGAGGAGAA
GACATGTTAATAACTGGAGGCCGCCATCCTTACCTTGGAAAGTACAAAGCTGGATTCATG
AACGATGGCAGAATCTTGGCCCTGGACATGGAGCATTACAGCAATGCAGGCGCCTCCTTG
GATGAATCATTATTCGTGATAGAAATGGGACTTCTGAAAATGGACAATGCTTACAAGTTT
CCCAATCTCCGCTGCCGGGGTTGGGCATGCAGAACCAACCTTCCATCCAACACAGCTTTT
CGTGGGTTTGGCTTTCCTCAGGCAGTGCTGATCACCGAATCTTGTATCACGGAAGTTGCA
GCCAAATGTGGACTATCCCCTGAGAAGGTGCGAATCATAAACATGTACAAGGAAATTGAT
CAAACACCCTACAAACAAGAGATCAATGCCAAGAACCTAATCCAGTGTTGGAGAGAATGT
ATGGCCATGTCTTCCTACTCCTTGAGGAAAGTTGCTGTGGAAAAGTTCAATGCAGAGAAT
TATTGGAAGAAGAAAGGACTGGCCATGGTCCCCCTGAAGTTTCCTGTTGGCCTTGCGTCA
CGTGCTGCTGGTCAGGCTGCTGCCTTGGTTCACATTTATCTTGATGGCTCTGTGCTGGTC
ACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTCAGC
CGTGAATTAAGAATGCCAATGTCGAATGTCCACCTGCGTGGAACAAGCACAGAAACTGTC
CCTAATGCAAATATCTCTGGAGGTTCTGTGGTGGCAGATCTCAACGGTTTGGCAGTAAAG
GATGCCTGTCAAACTCTTCTAAAACGCCTCGAACCCATCATCAGCAAGAATCCTAAAGGA
ACTTGGAAAGACTGGGCACAGACTGCTTTTGATGAAAGCATTAACCTTTCAGCTGTTGGA
TACTTCAGAGGTTATGAGTCAGACATGAACTGGGAGAAAGGCGAAGGCCAGCCCTTCGAA
TACTTTGTTTATGGAGCTGCCTGTTCCGAGGTTGAAATAGACTGCCTGACGGGGGATCAT
AAGAACATCAGAACAGACATTGTCATGGATGTTGGCTGCAGTATAAATCCAGCCATTGAC
ATAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAACTG
AATTATTCTCCCCAGGGCATTCTGCACACTCGTGGTCCAGACCAATATAAAATCCCTGCC
ATCTGTGACATGCCCACGGAGTTGCACATTGCTTTGTTGCCTCCTTCTCAAAACTCAAAT
ACTCTTTATTCATCTAAGGGTCTGGGAGAGTCGGGGGTGTTCCTGGGGTGTTCCGTGTTT
TTCGCTATCCATGACGCAGTGAGTGCAGCACGACAGGAGAGAGGCCTGCATGGACCCTTG
ACCCTTAATAGTCCACTGACCCCGGAGAAGATTAGGATGGCCTGTGAAGACAAGTTCACA
AAAATGATTCCGAGAGATGAACCTGGATCCTACGTTCCTTGGAATGTACCCATCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L11005

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q33

# Metabolic_Enzyme_1_SNPs:
rs41309768; rs3731722; rs2540065; rs1050887; rs1050884; rs2465665; rs2470900; rs2002957; rs1405984; rs2348021; rs2463492; rs2287013; rs868810; rs2465663; rs1527948; rs1527944; rs2463488; rs2348023; rs2470899; rs2465657; rs2254576; rs1527947; rs2348020; rs6753383; rs6745304; rs3769832; rs1918720; rs6753463; rs1986415; rs2293529; rs2470897; rs2293526; rs6712290; rs1527945; rs4428003; rs4619591; rs9288313; rs4496322; rs2540069; rs3795968; rs6725945; rs2470902; rs6720189; rs7560168; rs2293527; rs7597590; rs2248130; rs4672865; rs10497866; rs13400369; rs2293524; rs2287012; rs3815502; rs3815503; rs2256977; rs4672866; rs2715905; rs7597713; rs12478624; rs4614918; rs2293525; rs2465661; rs7563522; rs2293528; rs7572503; rs7587871; rs4674311; rs7585422; rs10187029; rs6742109; rs12693921; rs2241080; rs13419464; rs4672863; rs16833921; rs17448359; rs6737912; rs2465662; rs2241079; rs6760616; rs4674247; rs7563294; rs10172572; rs7420798; rs4672858; rs12997909; rs6761840; rs4470327; rs11677071; rs1405985; rs6435060; rs6730068; rs3769833; rs17593811; rs6761375; rs2463489; rs1986414; rs2881811; rs17532777; rs2347864; rs17533238; rs2244004; rs11694112; rs4035120; rs10469649; rs17532875; rs10432435; rs2287008; rs2348024; rs11689822; rs11886414; rs12617551; rs6730363; rs16833889; rs10497853; rs17532973; rs7586707; rs2540067; rs1405986; rs12618843; rs2465664; rs12472360; rs4541241; rs2348025; rs17532798; rs17448345; rs10497865; rs13404701; rs11887334; rs13023526; rs12993621; rs2287010; rs3769835; rs12472146; rs13383127; rs2715904; rs2348026; rs10183589; rs12612264; rs4672890; rs2960198; rs17533140; rs6732225; rs4456685; rs2347866; rs12478294; rs10180210; rs10469650; rs10469754; rs7426150; rs11897036; rs17532861; rs10179330; rs16833885; rs17533070; rs6711025; rs6761252; rs10931910; rs10204846; rs2540068; rs10931908; rs1527946; rs2247553; rs10206891; rs17533245; rs17448443; rs13419468; rs4674302; rs4503970; rs2715910; rs2465658; rs6754573; rs4508579; rs17448796; rs12620550; rs17448686; rs12620549; rs4674211; rs12620402; rs2715908; rs2287011; rs1986390; rs2287007; rs7562507; rs3769834; rs6735253; rs17636860; rs10207809; rs16833843; rs7595235; rs17448457; rs13406379; rs2960199; rs4674303; rs7569193; rs2463490; rs12612263; rs10183184; rs6724797; rs2715907; rs10179964; rs7598198; rs4337457; rs2516310; rs2347865; rs3820973; rs10210831; rs2540066; rs17448366; rs2072034; rs12621063; rs2715906; rs16833793; rs35345784; rs35217482; rs35128788; rs34799295; rs13023698; rs35999824; rs13408225; rs16833923; rs1050883; rs34427902; rs1131360; rs1050880; rs35293679; rs34110600; rs2241078; rs2348022; rs36084232; rs34698837; rs34892292; rs2463491; rs2470898; rs35076002; rs34217541; rs41270243; rs2715912; rs4674312; rs34095667; rs13402885; rs34380410; rs17594160; rs34436757; rs35754442; rs35527063; rs11901126; rs10460401; rs2465656; rs10192757; rs2287009; rs10179743; rs34769434; rs34936215; rs11420110; rs35886858; rs4384770; rs35423095; rs34397235; rs35057419; rs6741421; rs35569511; rs34169163; rs35035526; rs34423504; rs36054632; rs17533098; rs12466511; rs34606301; rs12464348; rs2470901; rs4350730; rs16833848; rs34138997; rs34016786; rs13008443; rs34185958; rs6435057; rs4672864; rs34356762; rs17448436; rs34831618; rs35918797; rs13391622; rs35794546; rs6147125; rs13034124; rs35778058; rs2960200; rs10192320; rs13423540; rs6728850; rs12993144; rs6728655; rs3769831; rs10931909; rs35245400; rs34772975; rs12988162; rs10623702; rs35236730; rs11373771; rs34817848; rs35482569; rs13035983; rs34032166; rs35483227; rs35482626; rs10191685; rs4035251; rs5018931; rs34962228; rs35020940; rs35045512; rs13019825; rs34887452; rs13393615; rs41271445; rs35698374; rs4622702; rs35086177; rs11676316; rs34332493; rs35539595; rs4674202; rs6147126; rs9808414; rs10203810; rs10192066; rs2465659; rs11455886; rs34798357; rs11397147; rs4261701; rs34408231; rs34266344; rs35993423; rs34473107; rs34930734; rs3038607; rs34303220; rs13432214; rs13432700; rs34560359; rs1989739; rs2715911; rs41270241; rs35309776; rs35763564; rs35987427; rs11684094; rs13385678; rs34620856; rs5837752; rs4621154; rs34299045; rs34602028; rs34451961; rs10664948; rs6750300; rs34882667; rs34272316; rs35908613; rs36046548; rs13398115; rs11680797; rs34570620; rs4674197; rs11370694; rs12621852; rs11677893; rs11678615; rs11684227; rs11691962; rs12622081; rs13026134; rs13027665; rs13419425; rs16834021; rs16834027; rs16834034; rs2540064; rs4132842; rs4132843; rs4674194; rs6729738; rs7563682; rs7594798; rs7607141; rs878403

# Metabolic_Enzyme_1_General_References:
8248161

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00017

Beginning of HMDB00019
# Accession_No:
HMDB00019

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 13:49:32

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
a-Ketoisovaleric acid

# Description:
A branched chain organic acid which is a precursor to leucine and valine synthesis.  It is also a degradation product from valine.  The enzyme dihydroxy-acid dehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, through the dehydration of 2, 3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid.

# Synonyms:
2-Ketoisovalerate; 2-Ketoisovaleric acid; 2-Oxo-3-methylbutanoate; 2-Oxo-3-methylbutanoic acid; 2-Oxo-3-methylbutyrate; 2-Oxo-3-methylbutyric acid; 2-Oxoisovalerate; 2-Oxoisovaleric acid; 2-keto-3-Methylbutyrate; 2-keto-3-Methylbutyric acid; 3-Methyl-2-oxobutanoate; 3-Methyl-2-oxobutanoic acid; 3-Methyl-2-oxobutyrate; 3-Methyl-2-oxobutyric acid; 3-methyl-2-oxo-Butanoate; 3-methyl-2-oxo-Butanoic acid; 3-methyl-2-oxo-Butyrate; 3-methyl-2-oxo-Butyric acid; Dimethylpyruvate; Dimethylpyruvic acid; Isopropylglyoxylate; Isopropylglyoxylic acid; Ketovaline; a-Ketoisovalerate; a-Oxo-b-methylbutyrate; a-Oxo-b-methylbutyric acid; a-Oxoisovalerate; a-Oxoisovaleric acid; a-keto-Isovalerate; a-keto-Isovaleric acid; a-keto-b-Methylbutyrate; a-keto-b-Methylbutyric acid; alpha-Ketoisovalerate; alpha-Ketoisovaleric acid; 3-Methyl-2-oxobutinoic acid; alpha-Oxo-beta-methylbutyrate; alpha-Oxo-beta-methylbutyric acid; alpha-Oxoisovalerate; alpha-Oxoisovaleric acid; alpha-keto-Isovalerate; alpha-keto-Isovaleric acid; alpha-keto-beta-Methylbutyrate; alpha-keto-beta-Methylbutyric acid

# Chemical_IUPAC_Name:
3-methyl-2-oxo-butanoic acid

# Chemical_Formula:
C5H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00019_ZOOM.png:::11928313195321121

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00019_THUMB.png:::119283131764430951

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
116.04735

# Molecular_Weight_Avg:
116.11522

# Smiles_String_isomeric:
CC(C)C(=O)C(O)=O

# Smiles_String_canonical:
CC(C)C(=O)C(O)=O

# KEGG_Compound_ID:
C00141

# BioCyc_ID:
2-KETO-ISOVALERATE

# PubChem_CID:
49

# PubChem_SID:
824662; 821865; 7888552; 8150431; 1955; 828266; 207009; 832649; 6591379; 3441; 8144675

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
34011

# Wikipedia_ID:
Not Available

# METLIN_ID:
5091

# Ref_ID:
2089249; 2026685; 7115325; 6422161; 6895847; 9869358; 5096137; 6393856; 6581765

# ChEBI_ID:
16530

# CAS_Registry_Number:
759-05-7

# InChI:
InChI=1/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)

# Synthesis_Reference:
Bouveault, L. etal., Bull. Soc. Chim. Fr., 1901, 1031; Singh, J. etal., Org. Prep. Proced. Int., 1989, 21, 501; Hata, H. etal., Synthesis, 1991, 289

# Melting_Point:
31.5 oC

# Melting_Point_predicted:
24.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 30.2 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.49 [Predicted by ALOGPS]; 0.1 [Predicted by PubChem via XLOGP]; -0.33 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00141.mol:::1132723801500830098

# SDF_File_[Text]:
tbl_chemical:::HMDB00019.sdf:::119283131422058484

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00019.pdb:::119283131601531789

# PDB_ID:
1HJG

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1HJG.txt:::1132720898859394396

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::061109_P00_17_1DP_noesy.png:::116890067315368550286

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::2_ketoisovalerate_NOESY-64nt_18dec06.fid.zip:::116655352084382847

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::061109_P00_17_1DP_Assigned.png:::118045513911514511

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954.png:::117147669883643953

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954.zip:::117147669884856102

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::061109_P00_17_IS_2DHSQC_1954_Assigned.png:::117147669901768156

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-methyl-2-oxo-Butanoic acid.gif:::1132732099203590048

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00019_peaks.txt:::1156309488303539646

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-methyl-2-oxo-Butanoic acid_C.gif:::1132737658178847141

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00019_peaks.txt:::1156310680269541330

# Mass_Spectrum:
Low Energy:tbl_ms:::00019L.png:::117891216966736364; Medium Energy:tbl_ms:::00019M.png:::117924567268334658Low Energy:tbl_ms:::negHMDB00019L.png:::118496310054080784; Medium Energy:tbl_ms:::negHMDB00019M.png:::118496310050451058; High Energy:tbl_ms:::negHMDB00019H.png:::118496310054396817

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000101.png:::116899931284336646

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000101.txt:::116899931284310418

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000101.png:::116890826996846977

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000101.txt:::11689082702969157

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.13 (0.00-0.54)	umol/mmol_creatinine	Adult:>18_yrs_old	Male	Normal	9869358
Urine	0.07 (0.01-0.45)	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	5096137
Blood	14.0 (0.0-28.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Blood	11.0 +/- 1.7	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	8.2 +/- 6.8 	uM	Adult:>18_yrs_old	Both	Normal	8412012


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Friedreich's Ataxia; Maple Syrup Urine Disease (MSUD)

# Pathway_Names:
Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;Valine,leucine,and_isoleucine_biosynthesis.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00290;map00770;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;Valine,leucine,and_isoleucine_biosynthesis.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5763

# Metabolic_Enzyme_1_Name:
Branched-chain-amino-acid aminotransferase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
BCAT(m; Placental protein 18; PP18

# Metabolic_Enzyme_1_Gene_Name:
BCAT2

# Metabolic_Enzyme_1_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, mitochondrial precursor
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV

# Metabolic_Enzyme_1_Number_of_Residues:
392

# Metabolic_Enzyme_1_Molecular_Weight:
44288

# Metabolic_Enzyme_1_Theoretical_pI:
8.82

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_1_Signals:
1-29

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2342862

# Metabolic_Enzyme_1_SwissProt_ID:
BCAT2_HUMAN (O15382)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BCAT2

# Metabolic_Enzyme_1_Geneatlas_id:
BCAT2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:977

# Metabolic_Enzyme_1_PDB_ID:
1KTA

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Isoform A:Mitochondrion. Isoform B:Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1179 bp
ATGGCCGCAGCCGCTCTGGGGCAGATCTGGGCACGAAAGCTTCTCTCTGTCCCTTGGCTT
CTGTGTGGTCCCAGAAGATATGCCTCCTCCAGTTTCAAGGCTGCAGACCTGCAGCTGGAA
ATGACACAGAAGCCTCATAAGAAGCCTGGCCCCGGCGAGCCCCTGGTGTTTGGGAAGACA
TTTACCGACCACATGCTGATGGTGGAATGGAATGACAAGGGCTGGGGCCAGCCCCGAATC
CAGCCCTTCCAGAACCTCACGCTGCACCCAGCCTCCTCCAGCCTCCACTACTCCCTGCAG
CTGTTTGAGGGCATGAAGGCGTTCAAAGGCAAAGACCAGCAGGTGCGCCTCTTCCGCCCC
TGGCTCAACATGGACCGGATGCTGCGCTCAGCCATGCGCCTGTGCCTGCCGAGTTTCGAC
AAGCTGGAGTTGCTGGAGTGCATCCGCCGGCTCATCGAAGTGGACAAGGACTGGGTCCCC
GATGCCGCCGGCACCAGCCTCTATGTGCGGCCTGTGCTCATTGGGAACGAGCCCTCGCTG
GGTGTCAGCCAGCCCAGGCGCGCGCTCCTGTTCGTCATTCTCTGCCCAGTGGGTGCCTAC
TTCCCTGGAGGCTCCGTGACCCCGGTCTCCCTCCTGGCCGACCCAGCCTTCATCCGGGCC
TGGGTGGGCGGGGTCGGCAACTACAAGTTAGGTGGGAATTATGGGCCCACCGTGTTAGTG
CAACAGGAGGCACTCAAGCGGGGCTGTGAACAGGTCCTCTGGCTGTATGGGCCCGACCAC
CAGCTCACCGAGGTGGGAACCATGAACATCTTTGTCTACTGGACCCACGAAGATGGGGTG
CTGGAGCTGGTGACGCCCCCGCTGAATGGTGTTATCCTGCCTGGAGTGGTCAGACAGAGT
CTACTGGACATGGCTCAGACCTGGGGTGAGTTCCGGGTGGTGGAGCGCACGATCACCATG
AAGCAGTTGCTGCGGGCCTTGGAGGAGGGCCGCGTGCGGGAAGTCTTTGGCTCGGGCACC
GCTTGCCAGGTCTGCCCAGTGCACCGAATCCTGTACAAAGACAGGAACCTCCATATTCCC
ACCATGGAAAATGGGCCTGAGCTGATCCTCCGCTTCCAGAAGGAGCTGAAGGAGATCCAG
TACGGAATCAGAGCCCACGAGTGGATGTTCCCGGTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U68418

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_1_Locus:
19q13

# Metabolic_Enzyme_1_SNPs:
rs11548193; rs837642; rs736170; rs566869; rs491459; rs4802507; rs4802509; rs4802508; rs521398; rs557106; rs12461998; rs4802510; rs11881788; rs575737; rs7257533; rs857526; rs4802504; rs35829476; rs526744; rs4801775; rs4801776; rs4802505; rs493841; rs6509405; rs684959; rs7249134; rs11665957; rs11548194; rs11548192; rs1132361; rs1052611; rs1052625; rs5828363; rs34189956; rs7251049; rs11310101; rs487703; rs41347145; rs7256054; rs7252854; rs11460106; rs35104437; rs3057799; rs35321803; rs35330344; rs34746454; rs11426980; rs12978094; rs11672905; rs10624703; rs34719140; rs34860510; rs11882009; rs11673677; rs12985962; rs35890345; rs34816112; rs12984148; rs35775607; rs35150864; rs35945446; rs4802506; rs34867589; rs11671146; rs35230038; rs10408884; rs36021046; rs35343377; rs36046536; rs1045379; rs11670491; rs11881731; rs11881904; rs12974796; rs2098684; rs3185254; rs35299026; rs3760788; rs482226; rs511779; rs524581; rs524942; rs545587; rs624028; rs656190; rs704244

# Metabolic_Enzyme_1_General_References:
9165094; 11170829; 8702755; 11264579; 12269802

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5534

# Metabolic_Enzyme_2_Name:
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta

# Metabolic_Enzyme_2_Gene_Name:
BCKDHB

# Metabolic_Enzyme_2_Protein_Sequence:
>2oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor
MAVVAAAAGWLLRLRAAGAEGHWRRLPGAGLARGFLHPAATVEDAAQRRQVAHFTFQPDP
EPREYGQTQK
MNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGKDRV
FNTPLCEQGIVGFGIGIAVTG
ATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCG
SLTIRSPWGCVGHGALYHSQSPEAFFAHCPGI
KVVIPRSPFQAKGLLLSCIEDKNPCIF
FEPKILYRAAAEEVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQ
VHVIREVASMAKEKLG
VSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQEECF
LNLEA
PISRVCGYDTPFPHIFEPFYIPDKWKCYDALRKMINY

# Metabolic_Enzyme_2_Number_of_Residues:
392

# Metabolic_Enzyme_2_Molecular_Weight:
43123

# Metabolic_Enzyme_2_Theoretical_pI:
6.24

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_2_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_2_Reaction:
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF02779:Transket_pyr;
PF02780:Transketolase_C

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.4.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179362

# Metabolic_Enzyme_2_SwissProt_ID:
ODBB_HUMAN (P21953)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
BCKDHB

# Metabolic_Enzyme_2_Geneatlas_id:
BCKDHB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:987

# Metabolic_Enzyme_2_PDB_ID:
1X80

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1179 bp

ATGGCGGTTGTAGCGGCGGCTGCCGGCTGGCTACTCAGGCTCAGGGCGGCAGGGGCTGA
GGGGCACTGGC
GTCGGCTTCCTGGCGCGGGGCTGGCGCGGGGCTTTTTGCACCCCGCCG
CGACTGTCGAGGATGCGGCCCA
GAGGCGGCAGGTGGCTCATTTTACTTTCCAGCCAGAT
CCGGAGCCCCGGGAGTACGGGCAAACTCAGAAA
ATGAATCTTTTCCAGTCTGTAACAAG
TGCCTTGGATAACTCATTGGCCAAAGATCCTACTGCAGTAATAT
TTGGTGAAGATGTTG
CCTTTGGTGGAGTCTTTAGATGCACTGTTGGCTTGCGAGACAAATATGGAAAAGA
TAGA
GTTTTTAATACCCCATTGTGTGAACAAGGAATTGTTGGATTTGGAATCGGAATTGCGGTC
ACTGGA
GCTACTGCCATTGCGGAAATTCAGTTTGCAGATTATATTTTCCCTGCATTTGA
TCAGATTGTTAATGAAG
CTGCCAAGTATCGCTATCGCTCTGGGGATCTTTTTAACTGTG
GAAGCCTCACTATCCGGTCCCCTTGGGG
CTGTGTTGGTCATGGGGCTCTCTATCATTCT
CAGAGTCCTGAAGCATTTTTTGCCCATTGCCCAGGAATC
AAGGTGGTTATACCCAGAAG
CCCTTTCCAGGCCAAAGGACTTCTTTTGTCATGCATAGAGGATAAAAATC
CTTGTATAT
TTTTTGAACCTAAAATACTTTACAGGGCAGCAGCGGAAGAAGTCCCTATAGAACCATACA
A
CATCCCACTGTCCCAGGCCGAAGTCATACAGGAAGGGAGTGATGTTACTCTAGTTGCC
TGGGGCACTCAG
GTTCATGTGATCCGAGAGGTAGCTTCCATGGCAAAAGAAAAGCTTGG
AGTGTCTTGTGAAGTCATTGATC
TGAGGACTATAATACCTTGGGATGTGGACACAATTT
GTAAGTCTGTGATCAAAACAGGGCGACTGCTAAT
CAGTCACGAGGCTCCCTTGACAGGC
GGCTTTGCATCGGAAATCAGCTCTACAGTTCAGGAGGAATGTTTC
TTGAACCTAGAGGC
TCCTATATCAAGAGTATGTGGTTATGACACACCATTTCCTCACATTTTTGAACCAT
TCT
ACATCCCAGACAAATGGAAGTGTTATGATGCCCTTCGAAAAATGATCAACTATTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M55575

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6q13-q15

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
2365818; 8651316; 2335211; 7918575; 8161368

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5536

# Metabolic_Enzyme_3_Name:
Branched-chain-amino-acid aminotransferase, cytosolic

# Metabolic_Enzyme_3_Synonyms:
BCAT(c; ECA39 protein

# Metabolic_Enzyme_3_Gene_Name:
BCAT1

# Metabolic_Enzyme_3_Protein_Sequence:
>Branchedchainaminoacid aminotransferase, cytosolic
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLSTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS

# Metabolic_Enzyme_3_Number_of_Residues:
386

# Metabolic_Enzyme_3_Molecular_Weight:
42953

# Metabolic_Enzyme_3_Theoretical_pI:
4.95

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  transaminase activity
Function:  branched-chain-amino-acid transaminase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine

# Metabolic_Enzyme_3_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00290  Valine, leucine and isoleucine biosynthesis;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_3_Reaction:
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01063:Aminotran_4

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.6.1.42

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1036780

# Metabolic_Enzyme_3_SwissProt_ID:
BCAT1_HUMAN (P54687)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
BCAT1

# Metabolic_Enzyme_3_Geneatlas_id:
BCAT1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:976

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1155 bp
ATGGATTGCAGTAACGGATCGGCAGAGTGTACCGGAGAAGGAGGATCAAAAGAGGTGGTG
GGGACTTTTAAGGCTAAAGACCTAATAGTCACACCAGCTACCATTTTAAAGGAAAAACCA
GACCCCAATAATCTGGTTTTTGGAACTGTGTTCACGGATCATATGCTGACGGTGGAGTGG
TCCTCAGAGTTTGGATGGGAGAAACCTCATATCAAGCCTCTTCAGAACCTGTCATTGCAC
CCTGGCTCATCAGCTTTGCACTATGCAGTGGAATTATTTGAAGGATTGAAGGCATTTCGA
GGAGTAGATAATAAAATTCGACTGTTTCAGCCAAACCTCAACATGGATAGAATGTATCGC
TCTGCTGTGAGGGCAACTCTGCCGGTATTTGACAAAGAAGAGCTCTTAGAGTGTATTCAA
CAGCTTGTGAAATTGGATCAAGAATGGGTCCCATATTCAACATCTGCTAGTCTGTATATT
CGTCCTGCATTCATTGGAACTGAGCCTTCTCTTGGAGTCAAGAAGCCTACCAAAGCCCTG
CTCTTTGTACTCTTGAGCCCAGTGGGACCTTATTTTTCAAGTGGAACCTTTAATCCAGTG
TCCCTGTGGGCCAATCCCAAGTATGTAAGAGCCTGGAAAGGTGGAACTGGGGACTGCAAG
ATGGGAGGGAATTACGGCTCATCTCTTTTTGCCCAATGTGAAGACGTAGATAATGGGTGT
CAGCAGGTCCTGTGGCTCTATGGCAGAGACCATCAGATCACTGAAGTGGGAACTATGAAT
CTTTTTCTTTACTGGATAAATGAAGATGGAGAAGAAGAACTGGCAACTCCTCCACTAGAT
GGCATCATTCTTCCAGGAGTGACAAGGCGGTGCATTCTGGACCTGGCACATCAGTGGGGT
GAATTTAAGGTGTCAGAGAGATACCTCACCATGGATGACTTGACAACAGCCCTGGAGGGG
AACAGAGTGAGAGAGATGTTTAGCTCTGGTACAGCCTGTGTTGTTTGCCCAGTTTCTGAT
ATACTGTACAAAGGCGAGACAATACACATTCCAACTATGGAGAATGGTCCTAAGCTGGCA
AGCCGCATCTTGAGCAAATTAACTGATATCCAGTATGGAAGAGAAGAGAGCGACTGGACA
ATTGTGCTATCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U21551

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12pter-q12

# Metabolic_Enzyme_3_SNPs:
rs7313020; rs17374285; rs1872644; rs2220269; rs1872645; rs6487421; rs2353483; rs4453321; rs6487420; rs1054277; rs2353481; rs1471842; rs1043851; rs3198082; rs1054281; rs1054279; rs1043881; rs12371993; rs4963801; rs7296995; rs7305794; rs2029986; rs11486; rs2200509; rs12578267; rs6487419; rs2353482; rs2046524; rs3825167; rs11047652; rs7134734; rs11047654; rs12231434; rs10842409; rs11047724; rs17371571; rs7134619; rs7306168; rs7315828; rs7134871; rs1872646; rs2046525; rs1471844; rs976436; rs2291894; rs2173606; rs2062497; rs2242400; rs7954529; rs3759085; rs1813470; rs7310300; rs11613673; rs7297229; rs4963596; rs11047676; rs6487428; rs10842418; rs10842431; rs937503; rs7296211; rs2029985; rs4963820; rs2046526; rs6487431; rs7296881; rs10771144; rs11610069; rs2352745; rs12425320; rs6487436; rs11047684; rs954200; rs3736212; rs2242399; rs7976928; rs7977807; rs4462438; rs6487435; rs7299023; rs7964239; rs12319639; rs954199; rs10466757; rs12424348; rs7968890; rs10505954; rs2133587; rs11047717; rs718567; rs11047686; rs7975904; rs3759086; rs10842413; rs6487434; rs11047679; rs4963822; rs7312749; rs6487429; rs2352746; rs16928083; rs10842414; rs7969149; rs3950612; rs10505952; rs10771142; rs6487437; rs16928141; rs12422599; rs2129236; rs1566406; rs12580682; rs10771138; rs4963810; rs2133588; rs16928207; rs16928163; rs16928145; rs12423866; rs4531567; rs16928217; rs6487433; rs11047685; rs2133582; rs11047716; rs10842429; rs7305924; rs7967945; rs1499805; rs11047709; rs7956863; rs7299760; rs11047692; rs12424211; rs7962203; rs954201; rs4963830; rs11609552; rs2047554; rs10771132; rs10842415; rs11047707; rs7959036; rs2353478; rs10505955; rs11047689; rs1546197; rs10842423; rs4143211; rs16928097; rs11047696; rs4963814; rs11047682; rs7978032; rs10771133; rs11608526; rs12318469; rs4963818; rs10160847; rs12366540; rs16928111; rs1119693; rs1566407; rs2353472; rs10842420; rs6487430; rs10842424; rs17314214; rs1392196; rs4143210; rs924191; rs11047708; rs1546196; rs12320158; rs1497257; rs4963594; rs10743524; rs10842416; rs3736211; rs12579934; rs12321766; rs10771140; rs10842427; rs10842433; rs7960010; rs10128933; rs7313260; rs16928089; rs7972930; rs7298696; rs1391028; rs12302883; rs10771139; rs10771130; rs9804952; rs7303413; rs4963804; rs10842421; rs7978793; rs12227915; rs7973974; rs10842417; rs2047555; rs7970244; rs10505953; rs4963808; rs1392195; rs10771128; rs7138654; rs2201712; rs10771141; rs10771127; rs11047674; rs7961778; rs2306766; rs11835201; rs3759088; rs16928168; rs11047693; rs7965655; rs4522264; rs10842422; rs11047665; rs10161442; rs16928173; rs7966104; rs12321731; rs4963805; rs10771146; rs3926539; rs11047712; rs2062495; rs4603392; rs11047711; rs11047721; rs2883181; rs1471843; rs12427117; rs10743526; rs12296255; rs11615930; rs12422783; rs11047697; rs11047706; rs4963802; rs1105937; rs11833854; rs10771129; rs4963823; rs17313239; rs10771143; rs10771134; rs10466799; rs7136436; rs10743521; rs7969444; rs17315488; rs12579655; rs12172778; rs7138685; rs3759087; rs4406910; rs1875092; rs11047677; rs2133589; rs7967953; rs7955672; rs7398085; rs7484721; rs10047592; rs12318827; rs11615863; rs4963806; rs4963821; rs12322309; rs11830394; rs7976171; rs16928186; rs11047714; rs11047668; rs4459405; rs7966783; rs10743525; rs12229422; rs6487427; rs12817139; rs1075061; rs4246225; rs7953453; rs12230816; rs12322341; rs7969612; rs12320547; rs12818299; rs11047700; rs11047715; rs7138806; rs1077102; rs17342494; rs2353479; rs17372766; rs7961688; rs4963817; rs11047723; rs12372519; rs17373566; rs5012437; rs12423288; rs16928169; rs11047669; rs7955886; rs11047695; rs17375619; rs17316319; rs1075062; rs12427184; rs7299787; rs11830163; rs12371441; rs11610213; rs2291895; rs11047678; rs11047681; rs9989035; rs11047691; rs11047671; rs11047667; rs11047699; rs12319283; rs12228257; rs4031159; rs12230878; rs11613710; rs11613482; rs4963815; rs7298907; rs7307610; rs11047702; rs2353473; rs10047590; rs10771145; rs12316589; rs17315467; rs1846581; rs1119692; rs2352747; rs10842434; rs11047660; rs7961152; rs11047657; rs10743527; rs7969649; rs1875091; rs4963593; rs7978338; rs4143212; rs4963811; rs16928171; rs11612450; rs12313518; rs2220270; rs2173605; rs11047722; rs4296116; rs10842430; rs16928149; rs7970200; rs12296315; rs10219671; rs2255206; rs2353484; rs2353485; rs3794263; rs7959326; rs10842436; rs1048368; rs2353486; rs10734736; rs7970725; rs1463625; rs1497255; rs7955676; rs1057204; rs35600421; rs17374606; rs4423275; rs35585041; rs11047651; rs35186964; rs12582215; rs15643; rs12366411; rs11433688; rs35804569; rs34453620; rs36085546; rs33947278; rs5797102; rs11047650; rs11384696; rs12301168; rs666928; rs12831930; rs35951011; rs36070747; rs12828108; rs10688526; rs12296452; rs34174229; rs34780357; rs4963819; rs34032061; rs34504461; rs34414606; rs5797104; rs34876959; rs5797105; rs34153775; rs12316475; rs7967922; rs665254; rs34501736; rs12817209; rs35203857; rs12422829; rs12296646; rs866358; rs12301149; rs11047661; rs35989805; rs12820872; rs34044660; rs35455721; rs34556925; rs1874598; rs7485585; rs10585254; rs35693234; rs35550560; rs11370314; rs12228347; rs5797108; rs11047687; rs11415752; rs10466800; rs11047659; rs35850216; rs17314570; rs625604; rs2270771; rs11047683; rs34237642; rs9804807; rs4963809; rs12817395; rs10585144; rs12310054; rs34835991; rs11616042; rs12300357; rs35406045; rs12319312; rs12229613; rs2649778; rs2133584; rs2291896; rs34227038; rs10842432; rs10595838; rs36124065; rs35488171; rs35203074; rs35427447; rs35151527; rs11608755; rs2133585; rs12823840; rs4031157; rs3950611; rs11615196; rs12818315; rs3044337; rs34802588; rs12816139; rs12816228; rs34677835; rs34476055; rs35060237; rs34165520; rs34902696; rs35984920; rs34151647; rs34717106; rs12310217; rs12818883; rs35033368; rs4963595; rs5797106; rs11047719; rs34329602; rs2645897; rs11310819; rs35929602; rs34808872; rs34508149; rs11047670; rs12825177; rs12827517; rs7968043; rs7980970; rs1693356; rs12810541; rs35423225; rs33963375; rs4432099; rs11047655; rs35331816; rs11047710; rs2645908; rs2649777; rs7309420; rs860869; rs10553165; rs28459289; rs12312774; rs11047666; rs35669075; rs12424534; rs11616041; rs35606332; rs17315509; rs12810226; rs11612132; rs35593379; rs2062496; rs10743522; rs11614032; rs7306822; rs35643898; rs11047703; rs35195819; rs2270772; rs2133583; rs11047720; rs35270432; rs34776365; rs11394415; rs28678340; rs10541735; rs35646001; rs840797; rs4963825; rs10643112; rs4963824; rs7970415; rs11047718; rs11047656; rs4963826; rs11327300; rs34707102; rs2133586; rs2883180; rs34370749; rs11440596; rs34430745; rs11392086; rs11047701; rs12319952; rs34143445; rs5797107; rs11047672; rs11047688; rs7296005; rs34780543; rs12227952; rs34331143; rs10561433; rs11318750; rs12230723; rs11047680; rs2645904; rs11345548; rs35939998; rs11614469; rs675368; rs4963807; rs596765; rs35566363; rs11442641; rs34858948; rs12320957; rs34377944; rs12313801; rs35181244; rs4963812; rs10616253; rs36137247; rs7972955; rs2220271; rs11047662; rs35801229; rs11047694; rs10697494; rs12817355; rs2645907; rs12581783; rs4031158; rs35477401; rs4031153; rs667888; rs1622629; rs4963813; rs2649776; rs34705263; rs35978550; rs11047704; rs34761531; rs7975240; rs3044287; rs12818310; rs12818301; rs7308285; rs7953787; rs10546505; rs36067986; rs35477889; rs7136511; rs34706565; rs34990218; rs16928147; rs34860589; rs12229575; rs36036274; rs11047705; rs35440053; rs11320109; rs866357; rs34549035; rs11047673; rs11047663; rs4400889; rs7131753; rs12367115; rs28491628; rs11047713; rs10548732; rs12830129; rs1075063; rs12582334; rs7968607; rs9668094; rs35277052; rs12821845; rs12299696; rs3830305; rs12371444; rs12831941; rs10589289; rs11369972; rs34420618; rs11047690; rs11831592; rs4257068; rs35063724; rs11047664; rs587649; rs10743523; rs10714031; rs11047698; rs668707; rs36035411; rs34285635; rs1497256; rs593165; rs9668028; rs35543389; rs10662028; rs5797103; rs35693867; rs3044290; rs9988971; rs34676819; rs10842435; rs35336188; rs1872643; rs10219508; rs10219610; rs1032589; rs10743520; rs10771123; rs10771124; rs10771125; rs10842408; rs10842437; rs10842439; rs11047645; rs11047647; rs11047648; rs11047726; rs11829886; rs1213075; rs12301529; rs12368831; rs12582944; rs12819423; rs1471841; rs16928015; rs17316445; rs17322922; rs17322957; rs34277634; rs34589683; rs35085353; rs4255624; rs4406909; rs4429151; rs4569089; rs4963795; rs4963796; rs4963797; rs4963800; rs619755; rs6487417; rs7299477; rs7307399; rs7961311; rs7961506; rs7964847; rs7979563; rs7979723

# Metabolic_Enzyme_3_General_References:
8692959

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5535

# Metabolic_Enzyme_4_Name:
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; BCKDE1A

# Metabolic_Enzyme_4_Gene_Name:
BCKDHA

# Metabolic_Enzyme_4_Protein_Sequence:
>2oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor
MAVAIAAARVWRLNRGLSQAALLLLRQPGARGLARSHPPRQQQQFSSLDDKPQFPGASAE
FIDKLEFIQP
NVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRIL
YESQRQGRISFYMTNYGEEGT
HVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQC
YGNISDLGKGRQMPVHYGCKERHFVTISSPLA
TQIPQAVGAAYAAKRANANRVVICYFG
EGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYR
GDGIAARGPGYGIMSI
RVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDE
VNYWD
KQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQE
MPAQL
RKQQESLARHLQTYGEHYPLDHFDK

# Metabolic_Enzyme_4_Number_of_Residues:
445

# Metabolic_Enzyme_4_Molecular_Weight:
50472

# Metabolic_Enzyme_4_Theoretical_pI:
8.41

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_4_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_4_Reaction:
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00676:E1_dh

# Metabolic_Enzyme_4_Signals:
1-32

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.4.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
29391

# Metabolic_Enzyme_4_SwissProt_ID:
ODBA_HUMAN (P12694)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
BCKDHA

# Metabolic_Enzyme_4_Geneatlas_id:
BCKDHA

# Metabolic_Enzyme_4_hgnc_id:
HGNC:986

# Metabolic_Enzyme_4_PDB_ID:
1U5B

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1338 bp

ATGGCGGTAGCGATCGCTGCAGCGAGGGTCTGGCGGCTAAACCGTGGTTTGAGCCAGGC
TGCCCTCCTGC
TGCTGCGGCAGCCTGGGGCTCGGGGACTGGCTAGATCTCACCCCCCCA
GGCAGCAGCAGCAGTTTTCATC
TCTGGATGACAAGCCCCAGTTCCCAGGGGCCTCGGCG
GAGTTTATAGATAAGTTGGAATTCATCCAGCCC
AACGTCATCTCTGGAATCCCCATCTA
CCGCGTCATGGACCGGCAAGGCCAGATCATCAACCCCAGCGAGG
ACCCCCACCTGCCGA
AGGAGAAGGTGCTGAAGCTCTACAAGAGCATGACACTGCTTAACACCATGGACCG
CATC
CTCTATGAGTCTCAGCGGCAGGGCCGGATCTCCTTCTACATGACCAACTATGGTGAGGAG
GGCACG
CACGTGGGGAGTGCCGCCGCCCTGGACAACACGGACCTGGTGTTTGGCCAGTA
CCGGGAGGCAGGTGTGC
TGATGTATCGGGACTACCCCCTGGAACTATTCATGGCCCAGT
GCTATGGCAACATCAGTGACTTGGGCAA
GGGGCGCCAGATGCCTGTCCACTACGGCTGC
AAGGAACGCCACTTCGTCACTATCTCCTCTCCACTGGCC
ACGCAGATCCCTCAGGCGGT
GGGGGCGGCGTACGCAGCCAAGCGGGCCAATGCCAACAGGGTCGTCATCT
GTTACTTCG
GCGAGGGGGCAGCCAGTGAGGGGGACGCCCATGCCGGCTTCAACTTCGCTGCCACACTTG
A
GTGCCCCATCATCTTCTTCTGCCGGAACAATGGCTACGCCATCTCCACGCCCACCTCT
GAGCAGTATCGC
GGCGATGGCATTGCAGCACGAGGCCCCGGGTATGGCATCATGTCAAT
CCGCGTGGATGGTAATGATGTGT
TTGCCGTATACAACGCCACAAAGGAGGCCCGACGGC
GGGCTGTGGCAGAGAACCAGCCCTTTCTCATCGA
GGCCATGACCTACAGGATCGGGCAC
CACAGCACCAGTGACGACAGTTCAGCGTACCGCTCGGTGGATGAG
GTCAATTACTGGGA
TAAACAGGACCACCCCATCTCCCGGCTGCGGCACTATCTGCTGAGCCAAGGCTGGT
GGG
ATGAGGAGCAGGAGAAGGCCTGGAGGAAGCAGTCCCGCAGGAAGGTGATGGAGGCCTTTG
AGCAGGC
CGAGCGGAAGCCCAAACCCAACCCCAACCTGCTCTTCTCAGACGTGTATCAG
GAGATGCCCGCCCAGCTC
CGCAAGCAGCAGGAGTCTCTGGCCCGCCACCTGCAGACCTA
CGGGGAGCACTACCCACTGGATCACTTCG
ATAAGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
Z14093

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_4_Locus:
19q13.1-q13.2

# Metabolic_Enzyme_4_SNPs:
rs34589432; rs34442879; rs284652; rs4674; rs10404506; rs34492894; rs284650; rs284656; rs10409485; rs284655; rs1473248; rs6508977; rs11672345; rs4803461; rs4803465; rs284653; rs4803463; rs4803464; rs284654; rs2288871; rs284647; rs3816037; rs11083619; rs10416743; rs284657; rs11880951; rs11670757; rs8108664; rs11879090; rs3213860; rs11880539; rs284658; rs284649; rs2241711; rs12709849; rs4803468; rs4803462; rs284648; rs4802116; rs2241710; rs2288870; rs2241707; rs3217386; rs3217385; rs12459859; rs11670725; rs10420556; rs1967334; rs3213861; rs12327776; rs10418291; rs7258787; rs4803469; rs1967333; rs4802117; rs11670668; rs12982607; rs10415116; rs10422783; rs2241706; rs16975216; rs11670583; rs7258973; rs12980966; rs2241709; rs10413735; rs284651; rs10422226; rs2241708; rs4802118; rs4803467; rs10410801; rs34956071; rs11549938; rs11549937; rs12980789; rs12973059; rs4803466; rs10565264; rs3214612; rs166925; rs35024134; rs10425437; rs10554793; rs10405951; rs3061207; rs35487663; rs11300069; rs9710116; rs11666243; rs13343330; rs11437195; rs8102338; rs34391204; rs35668703; rs10418917; rs34978824; rs34107638; rs12327735; rs10409251; rs10407077; rs10418669; rs10419188; rs2288872; rs12979462; rs34447852; rs10408639; rs11671704; rs10411013; rs35085046; rs34919809; rs12971746; rs5828106; rs10406198; rs11437196; rs10424533; rs13346233; rs11307304; rs10414106; rs34933875; rs28374474; rs5828107; rs10426536; rs11307062; rs12327737; rs11671665; rs11883104; rs33988947; rs35214178; rs35521052; rs7257117; rs10413269; rs10418899; rs10421104; rs10422956; rs10423332; rs1043413; rs1050647; rs10853751; rs11539797; rs11878656; rs12983789; rs17318596; rs2231943; rs2231944; rs2231945; rs2231946; rs284660; rs284661; rs284662; rs284663; rs34169026; rs34500671; rs34541442; rs35286725; rs35615017; rs3810174; rs3810175; rs7248964; rs7249410; rs7259208; rs747239; rs878082; rs878083; rs892044

# Metabolic_Enzyme_4_General_References:
1420356; 2914958; 2060625; 1682165; 3224821; 7918575; 10745006; 8037208; 2703538; 2241958; 1867199; 1885764; 8161368; 7883996

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
8614

# Metabolic_Enzyme_5_Name:
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
Dihydrolipoyllysine-residue; 2-methylpropanoyltransferase; E2; Dihydrolipoamide branched chain transacylase; BCKAD E2 subunit

# Metabolic_Enzyme_5_Gene_Name:
DBT

# Metabolic_Enzyme_5_Protein_Sequence:
>Lipoamide acyltransferase component of branchedchain alphaketo acid dehydrogenase complex, mitochondrial precursor
MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAAL
RGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKK
LYYNLDDIAYVGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRL
AMENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPIL
VSKPPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFA
RGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVK
NVQICSIFDIATELNRLQKLGSVGQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAI
GALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLD
LK

# Metabolic_Enzyme_5_Number_of_Residues:
482

# Metabolic_Enzyme_5_Molecular_Weight:
53488

# Metabolic_Enzyme_5_Theoretical_pI:
8.75

# Metabolic_Enzyme_5_GO_Classification:
>>>
 Function:  binding
Function:  protein binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion

# Metabolic_Enzyme_5_Specific_Function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00198:2-oxoacid_dh
PF00364:Biotin_lipoyl
PF02817:E3_binding

# Metabolic_Enzyme_5_Signals:
1-15

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.3.1.168

# Metabolic_Enzyme_5_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_5_SwissProt_ID:
ODB2_HUMAN (P11182)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
DBT

# Metabolic_Enzyme_5_Geneatlas_id:
DBT

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2698

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
Not Available

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X66785

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p31

# Metabolic_Enzyme_5_SNPs:
rs12021720; rs11166414; rs7515169; rs7543453; rs2810423; rs4243806; rs7541105; rs2810424; rs10783127; rs4143060; rs4143055; rs6577160; rs4143056; rs4143054; rs3131839; rs7411584; rs6681747; rs6691159; rs2784176; rs4463693; rs6682782; rs4443908; rs6577158; rs6678629; rs10127510; rs2810425; rs12046458; rs7531657; rs10127954; rs10127458; rs10127624; rs7526860; rs4457600; rs17122068; rs6577161; rs12036284; rs6681732; rs17122062; rs4536026; rs12563896; rs11166415; rs11166420; rs4908045; rs12730828; rs11580205; rs11166417; rs6577159; rs6675037; rs6577156; rs10875281; rs4143058; rs4143059; rs4908050; rs12566522; rs3131838; rs12731146; rs11578881; rs4908049; rs4443909; rs6700203; rs12043921; rs12757077; rs11166418; rs4385734; rs11166419; rs4908048; rs4443907; rs6577157; rs11800446; rs4907905; rs4908047; rs7519172; rs3122123; rs4907904; rs10127453; rs4908046; rs17122057; rs12135215; rs3806235; rs3806238; rs7520551; rs3806236; rs3806237; rs2784174; rs34267966; rs34216222; rs2210835; rs12121012; rs1141149; rs1055938; rs1141150; rs36009006; rs11431894; rs12727372; rs34816108; rs34088406; rs11284142; rs10569169; rs12754742; rs34588666; rs12124225; rs6687213; rs10569170; rs36076189; rs34507136; rs10443197; rs10641409; rs35150096; rs12565098; rs35280314; rs5776501; rs4495725; rs4908044; rs4143057; rs11352287; rs36074370; rs9701856; rs34905359; rs35464102; rs9700526; rs12120030; rs36130836; rs11369687; rs4908043; rs36195710; rs34229137; rs11584177; rs35771966; rs34446927; rs12134966; rs4243807; rs3898422; rs12737671; rs12130715; rs36169768; rs12731147; rs36048113; rs35509059; rs10587917; rs10707303; rs11275801; rs35975149; rs34033652; rs4587586; rs35177080; rs34533441; rs34230047; rs35815229; rs10648531; rs28375752; rs33967889; rs12754720; rs35977630; rs12140583; rs35406160; rs11579298; rs10716275; rs12735769; rs14964; rs11394110; rs10680510; rs35766227; rs34976609; rs34912416; rs41287254; rs3122124; rs10747506; rs11166412; rs11166413; rs11801766; rs12044663; rs12085550; rs3122125; rs3131836; rs3131837; rs4397673; rs4604709; rs6577155; rs6701655

# Metabolic_Enzyme_5_General_References:
1420314; 3245861; 2708389; 2742576; 2837277; 1429740; 7918575; 11839747; 1847055; 9621512

# Metabolic_Enzyme_5_References:
Not Available

End of HMDB00019

Beginning of HMDB00020
# Accession_No:
HMDB00020

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 13:57:05

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
p-Hydroxyphenylacetic acid

# Description:
An oxidative deaminated metabolite of p-tyramine. Also a metabolite of tyrosine via enteric bacteria.  The bacterial origin of this compound was confirmed by the finding that this compound in urine decreased significantly after the use of the antibiotic neomycin.

# Synonyms:
(4-Hydroxy-phenyl)-essigsaeure; (4-hydroxy-phenyl)-acetate; (4-hydroxy-phenyl)-acetic acid; (4-hydroxyphenyl)acetate; (4-hydroxyphenyl)acetic acid; (p-Hydroxyphenyl)acetate; (p-Hydroxyphenyl)acetic acid; (p-hydroxyphenyl)-Acetate; (p-hydroxyphenyl)-Acetic acid; 4-Hydroxy-Benzeneacetate; 4-Hydroxy-Benzeneacetic acid; 4-Hydroxybenzeneacetate; 4-Hydroxybenzeneacetic acid; 4-hydroxyphenylacetate; 4-hydroxyphenylacetic acid; Parahydroxy phenylacetate; Parahydroxy phenylacetic acid; Parahydroxyphenylacetate; p-hydroxyphenylacetate; p-hydroxyphenylacetic acid

# Chemical_IUPAC_Name:
2-(4-hydroxyphenyl)acetic acid

# Chemical_Formula:
C8H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00020_ZOOM.png:::119283132892118367

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00020_THUMB.png:::119283132697199879

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; carboxylic acid; aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
152.04735

# Molecular_Weight_Avg:
152.14732

# Smiles_String_isomeric:
OC(=O)CC1=CC=C(O)C=C1

# Smiles_String_canonical:
OC(=O)CC1=CC=C(O)C=C1

# KEGG_Compound_ID:
C00642

# BioCyc_ID:
4-HYDROXYPHENYLACETATE

# PubChem_CID:
127

# PubChem_SID:
7885355; 8143891; 10387358; 3915; 819277; 11231199; 8001827; 835447; 2029; 8150470; 7990051; 87926; 3133496; 10509268; 86366; 4533640; 152263

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
35599

# Wikipedia_ID:
Not Available

# METLIN_ID:
130

# Ref_ID:
15853358; 11997029; 7116636; 6883916; 6181210; 14708889; 455649; 8087979; 4903899; 12797864; 12971945; 11152462; 6085021; 15721987

# ChEBI_ID:
18101

# CAS_Registry_Number:
156-38-7

# InChI:
InChI=1/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)

# Synthesis_Reference:
Looker, J.H., J.O.C., 1954, 19, 784-788; Bodor, N. etal., J. Med. Chem., 1988, 31, 1651-1656

# Melting_Point:
148-150 oC

# Melting_Point_predicted:
103.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
60.7 mg/mL [GRACIN,S & RASMUSON,AC (2002)]

# H2O_Solubility_Predicted:
7.12 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
0.75 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
0.93 [Predicted by ALOGPS]; 1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00642.mol:::1132723801593939274

# SDF_File_[Text]:
tbl_chemical:::HMDB00020.sdf:::11928313235011408

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00020.pdb:::119283132529451513

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_presat_1.png:::115272187455710256

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_presat_2.zip:::115272222216267399

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_06_IS_1DP_Assigned.png:::115628170659952754

# C_NMR_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133.png:::114791051506413891

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133.zip:::114791051508932990

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050106_P00_06_IS_1DC_133_Assigned.png:::115999279896944016

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71.png:::114805641972412517

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71.zip:::114805641973130528

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_06_IS_2DHSQC_71_Assigned.png:::115999283803544123

# Predicted_H_NMR_Spectrum:
tbl_chemical:::4-Hydroxyphenylacetic acid.gif:::1132732099250704431

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00020_peaks.txt:::1156309489334549951

# Predicted_C_NMR_Spectrum:
tbl_chemical:::4-Hydroxyphenylacetic acid_C.gif:::1132737658218635811

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00020_peaks.txt:::1156310681295788839

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00020L.png:::117555263318947066; Medium Energy:tbl_ms:::HMDB00020M.png:::117555268523919871; High Energy:tbl_ms:::HMDB00020H.png:::117555271848664169

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Bladder; Epidermis; Kidney

# deuterated:
No

# Biofluid_Location:
Blood; Saliva; Urine

# Concentration_[Normal]:
Urine	23 (20-26)	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	14	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	30	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	24.2	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	14708889
Urine	36.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	14708889
Urine	20.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	31.4	umol/mmol_creatinine	Adolescent:13-18_yrs_old	Both	Normal	14708889
Urine	15.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	14708889
Urine	24.2	umol/mmol_creatinine	Newborn:0-30_days_old	Both	Normal	8087979
Urine	36.7	umol/mmol_creatinine	Infant:0-1_yr_old	Both	Normal	8087979
Urine	20.3	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	31.4	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	8087979
Urine	15.3	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8087979
Blood	0.230 (0.070-0.390)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	4.9 (1.8-8.0)	umol/L	Adult:>18_yrs_old	Both	Normal	17536823
Saliva	7.0 (2.0-10.0)	uM	Adult:>18_yrs_old	Both	Normal	11997029


# Concentration_[Abnormal]:
Urine	16 +/- 15	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Urine	18-150	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Spina bifida	4903899


# Associated_Disorders:
Celiac Disease (Gluten Sensitivity); Enteritis; Epileptic; Intestinal Resection; Lung Cancer; Schizophrenic; Spina bifida

# Pathway_Names:
Glycolysis

# Pathway_Images:
Glycolysis.jpg

# KEGG_Images:
map00010

# Pathway_Graphs:
Glycolysis_Graph.jpg

# Pathway_SBMLs:
Glycolysis.xml

# Metabolic_Enzyme_1_ID:
5810

# Metabolic_Enzyme_1_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_1_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_1_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_1_Number_of_Residues:
385

# Metabolic_Enzyme_1_Molecular_Weight:
42670

# Metabolic_Enzyme_1_Theoretical_pI:
5.97

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_1_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_1_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_1_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_1_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_1_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:411

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11q13

# Metabolic_Enzyme_1_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_1_General_References:
7484374; 8890755

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5529

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_2_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_2_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_2_Number_of_Residues:
512

# Metabolic_Enzyme_2_Molecular_Weight:
56109

# Metabolic_Enzyme_2_Theoretical_pI:
7.29

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_2_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:409

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_2_Locus:
15q26.3

# Metabolic_Enzyme_2_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_2_General_References:
7698756

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5527

# Metabolic_Enzyme_3_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_3_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_3_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_3_Number_of_Residues:
453

# Metabolic_Enzyme_3_Molecular_Weight:
50380

# Metabolic_Enzyme_3_Theoretical_pI:
6.52

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_3_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_3_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_3_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:405

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_3_Locus:
17p11.2

# Metabolic_Enzyme_3_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_3_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5811

# Metabolic_Enzyme_4_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_4_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_4_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_4_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_4_Number_of_Residues:
468

# Metabolic_Enzyme_4_Molecular_Weight:
51840

# Metabolic_Enzyme_4_Theoretical_pI:
7.67

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_4_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_4_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_4_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_4_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_4_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:410

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_4_Locus:
11q13

# Metabolic_Enzyme_4_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_4_General_References:
7828891

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5514

# Metabolic_Enzyme_5_Name:
Myeloperoxidase precursor

# Metabolic_Enzyme_5_Synonyms:
MPO[Contains: 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]

# Metabolic_Enzyme_5_Gene_Name:
MPO

# Metabolic_Enzyme_5_Protein_Sequence:
>Myeloperoxidase precursor
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS

# Metabolic_Enzyme_5_Number_of_Residues:
745

# Metabolic_Enzyme_5_Molecular_Weight:
83870

# Metabolic_Enzyme_5_Theoretical_pI:
9.14

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

# Metabolic_Enzyme_5_Pathway:
map00360  Phenylalanine metabolism;
 map00590  Prostaglandin and leukotriene metabolism;
 map00680  Methane metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis

# Metabolic_Enzyme_5_Reaction:
donor + H2O2 = oxidized donor + 2 H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03098:An_peroxidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.11.1.7

# Metabolic_Enzyme_5_GenBank_ID_Protein:
189040

# Metabolic_Enzyme_5_SwissProt_ID:
PERM_HUMAN (P05164)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
MPO

# Metabolic_Enzyme_5_Geneatlas_id:
MPO

# Metabolic_Enzyme_5_hgnc_id:
HGNC:7218

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_5_Gene_Sequence:
>2238 bp
ATGGGGGTTCCCTTCTTCTCTTCTCTCAGATGCATGGTGGACTTAGGACCTTGCTGGGCT
GGGGGTCTCACTGCAGAGATGAAGCTGCTTCTGGCCCTAGCAGGGCTCCTGGCCATTCTG
GCCACGCCCCAGCCCTCTGAAGGTGCTGCTCCAGCTGTCCTGGGGGAGGTGGACACCTCG
TTGGTGCTGAGCTCCATGGAGGAGGCCAAGCAGCTGGTGGACAAGGCCTACAAGGAGCGG
CGGGAAAGCATCAAGCAGCGGCTTCGCAGCGGCTCAGCCAGCCCCATGGAACTCCTATCC
TACTTCAAGCAGCCGGTGGCAGCCACCAGGACGGCGGTGAGGGCCGCTGACTACCTGCAC
GTGGCTCTAGACCTGCTGGAGAGGAAGCTGCGGTCCCTGTGGCGAAGGCCATTCAATGTC
ACTGATGTGCTGACGCCCGCCCAGCTGAATGTGTTGTCCAAGTCAAGCGGCTGCGCCTAC
CAGGACGTGGGGGTGACTTGCCCGGAGCAGGACAAATACCGCACCATCACCGGGATGTGC
AACAACAGACGCAGCCCCACGCTGGGGGCCTCCAACCGTGCCTTTGTGCGCTGGCTGCCG
GCGGAGTATGAGGACGGCTTCTCTCTTCCCTACGGCTGGACGCCCGGGGTCAAGCGCAAC
GGCTTCCCGGTGGCTCTGGCTCGCGCGGTCTCCAACGAGATCGTGCGCTTCCCCACTGAT
CAGCTGACTCCGGACCAGGAGCGCTCACTCATGTTCATGCAATGGGGCCAGCTGTTGGAC
CACGACCTCGACTTCACCCCTGAGCCGGCCGCCCGGGCCTCCTTCGTCACTGGCGTCAAC
TGCGAGACCAGCTGCGTTCAGCAGCCGCCCTGCTTCCCGCTCAAGATCCCGCCCAATGAC
CCCCGCATCAAGAACCAAGCCGACTGCATCCCGTTCTTCCGCTCCTGCCCGGCTTGCCCC
GGGAGCAACATCACCATCCGCAACCAGATCAACGCGCTCACTTCCTTCGTGGACGCCAGC
ATGGTGTACGGCAGCGAGGAGCCCCTGGCCAGGAACCTGCGCAACATGTCCAACCAGCTG
GGGCTGCTGGCCGTCAACCAGCGCTTCCAAGACAACGGCCGGGCCCTGCTGCCCTTTGAC
AACCTGCACGATGACCCCTGTCTCCTCACCAACCGCTCAGCGCGCATCCCCTGCTTCCTG
GCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTT
CGGGAGCACAACCGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAG
AGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTCCAGATCATCACTTACCGG
GACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGT
TCCTACAATGACTCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTAC
GGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAATCGGTACCAGCCCATGGAA
CCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAA
GGTGGCATTGACCCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAG
AACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAGCAGGTCATGAGGATTGGG
CTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAAT
GCCTGGAGGCGCTTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTG
CTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTATGGCACGCCCAACAACATC
GACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTC
CTCGCCTGCATCATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGG
GAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTGGCCCAGATCTCATTGCCC
CGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCC
AACTCATATCCCCGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCC
TGGAGGGAAGCCTCCTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
J02694

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_5_Locus:
17q23.1

# Metabolic_Enzyme_5_SNPs:
rs7208693; rs2759; rs28730835; rs35314437; rs34628871; rs6503857; rs2856857; rs28396732; rs2071409; rs8067377; rs8082134; rs34506259; rs34704261; rs35921530; rs35840794; rs34028830; rs35087219; rs34376256; rs34212101; rs35400724; rs35112109; rs11575868; rs34471705; rs34914394; rs34673822; rs11649901; rs916115; rs35709273; rs7220117; rs8079006; rs2243828; rs2107545; rs2243827; rs8178426; rs2333227; rs12601419; rs34539862; rs34070619; rs34097845; rs34565045; rs8178428; rs35702888; rs35670089; rs2856856; rs28730837; rs35755750; rs2856855; rs35897051; rs35352616; rs8073898; rs11555567; rs34738107; rs11575867; rs2856859; rs2856858; rs2526363; rs11489012; rs2526362; rs2856852; rs34108145; rs28730838; rs11489013; rs2526364; rs12939070; rs34646152; rs12939069; rs11659055; rs34496983; rs36015586; rs35966215; rs35550002; rs36000892; rs35977697; rs2856864; rs34802326; rs8081735; rs2856861; rs11272526; rs34685535; rs2107546; rs34151601; rs36049426; rs916116; rs2526366; rs34341256; rs35614168; rs2856863; rs2856860; rs2526365; rs35830722; rs35286509; rs34841676; rs2856865; rs35922881; rs35369873; rs34432014; rs34576380; rs8178425; rs35412618; rs35433825; rs34240282; rs916114; rs34534274; rs2856854; rs34721594; rs35619750; rs8178429; rs2856853; rs8178424; rs8178427; rs34626646; rs11650865; rs12452417; rs12453852; rs12949848; rs16942910; rs2856862; rs34853811; rs3744104; rs4401102; rs8178373; rs8178375; rs8178378; rs8178380; rs8178381; rs8178384; rs8178386; rs8178387; rs8178392; rs8178395; rs8178398; rs8178404; rs8178405; rs8178406; rs8178407; rs8178409; rs8178410; rs8178412; rs8178415; rs8178416; rs8178417; rs8178418

# Metabolic_Enzyme_5_General_References:
3029127; 2444596; 3031585; 2552418; 3654979; 2903767; 8383257; 8390465; 2884926; 2154223; 10766826; 7840679; 11705390; 8142659; 7904599; 8621627; 9637725; 9354683

# Metabolic_Enzyme_5_References:
11054430; 9065416

End of HMDB00020

Beginning of HMDB00021
# Accession_No:
HMDB00021

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-16 11:27:57

# biospider_lastupdate:
2007-07-24 17:06:08

# Common_Name:
Iodotyrosine

# Description:
An iodated derivative of L-tyrosine.  This is an early precursor to L-thyroxine, one of the primary thyroid hormones.  In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase.  Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants.    Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.

# Synonyms:
Monoiodotyrosine; 3-Iodo-L-tyrosine; MIT; 3-Monoiodo-L-tyrosine; 3-Iodotyrosine; 3-Iodo-4-hydroxyphenylalanine; IYR; 3-iodo-tyrosine; (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid; 4-Hydroxy-3-iodophenylalanine; L-Tyrosine-3-iodo

# Chemical_IUPAC_Name:
(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

# Chemical_Formula:
C9H10INO3

# Chemical_Structure:
tbl_chemical:::HMDB00021_ZOOM.png:::119283133833215950

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00021_THUMB.png:::119283133639499691

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alpha-aminoacid; carboxylic acid; aromatic compound; primary amine; aryl iodide; primary aliphatic amine (alkylamine); phenol or hydroxyhetarene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
306.97052

# Molecular_Weight_Avg:
307.08508

# Smiles_String_isomeric:
N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O

# Smiles_String_canonical:
NC(CC1=CC=C(O)C(I)=C1)C(O)=O

# KEGG_Compound_ID:
C02515

# BioCyc_ID:
IODO-L-TYROSINE

# PubChem_CID:
439744

# PubChem_SID:
7888504; 8144448; 24278154; 855708; 3133565; 17405234; 7979635; 585618; 5525; 10298449; 16147179

# OMIM_ID:
274800

# Metagene_ID:
Not Available

# BiGG_ID:
39998

# Wikipedia_ID:
Not Available

# METLIN_ID:
Not Available

# Ref_ID:
12409460; 108034; 838849; 1127080; 6133737; 12013218

# ChEBI_ID:
27847

# CAS_Registry_Number:
70-78-0

# InChI:
InChI=1/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

# Synthesis_Reference:
 Chemical Engineering Research and Design  (1983),  61(5),  297-302.

# Melting_Point:
205 oC

# Melting_Point_predicted:
113.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
3 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
124.0 mg/mL [MEYLAN,WM et al. (1996)]; 0.937 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.7 [Predicted by PubChem via XLOGP]; -1.50 [Predicted by ALOGPS]; -0.60 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02515.mol:::1132723801750493913

# SDF_File_[Text]:
tbl_chemical:::HMDB00021.sdf:::119283133287953100

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00021.pdb:::119283133471450116

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041112_01_PO_1DP_presat.png:::114850386824314889

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041112_P00_01_HW_1DP_PRESAT_1.zip:::1141683750443165

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::041112_P00_01_HW_1DP_Assigned.png:::115628337230117484

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894.png:::11480567096163208

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894.zip:::11480567096236374

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041112_P00_01_HW_2DHSQC_894_Assigned.png:::116180693848325175

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Iodo-L-Tyrosine.gif:::11327320993127718

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00021_peaks.txt:::1156309490398286963

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Iodo-L-Tyrosine_C.gif:::1132737658278857556

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00021_peaks.txt:::1156310682305210537

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00021L.png:::117555261789516917; Medium Energy:tbl_ms:::HMDB00021M.png:::117555266899279535; High Energy:tbl_ms:::HMDB00021H.png:::117555270743442367

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Congenital Hypothyroidism; Deiodinase Deficiency; Iodotyrosine Dehalogenase Deficiency

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5508

# Metabolic_Enzyme_1_Name:
Thyroid peroxidase precursor

# Metabolic_Enzyme_1_Synonyms:
TPO

# Metabolic_Enzyme_1_Gene_Name:
TPO

# Metabolic_Enzyme_1_Protein_Sequence:
>Thyroid peroxidase precursor
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRATWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL

# Metabolic_Enzyme_1_Number_of_Residues:
933

# Metabolic_Enzyme_1_Molecular_Weight:
102932

# Metabolic_Enzyme_1_Theoretical_pI:
6.75

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)

# Metabolic_Enzyme_1_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_1_Reaction:
iodide + H2O2 = iodine + 2 H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF07645:EGF_CA;
PF00084:Sushi

# Metabolic_Enzyme_1_Signals:
1-14

# Metabolic_Enzyme_1_Transmembrane_Regions:
847-871

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.11.1.8

# Metabolic_Enzyme_1_GenBank_ID_Protein:
339867

# Metabolic_Enzyme_1_SwissProt_ID:
PERT_HUMAN (P07202)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TPO

# Metabolic_Enzyme_1_Geneatlas_id:
TPO

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12015

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>2802 bp
ATGAGAGCGCTCGCTGTGCTGTCTGTCACGCTGGTTATGGCCTGCACAGAAGCCTTCTTC
CCCTTCATCTCGAGAGGGAAAGAACTCCTTTGGGGAAAGCCTGAGGAGTCTCGTGTCTCT
AGCGTCTTGGAGGAAAGCAAGCGCCTGGTGGACACCGCCATGTACGCCACGATGCAGAGA
AACCTCAAGAAAAGAGGAATCCTTTCTCCAGCTCAGCTTCTGTCTTTTTCCAAACTTCCT
GAGCCAACAAGCGGAGTGATTGCCCGAGCAGCAGAGATAATGGAAACATCAATACAAGCG
ATGAAAAGAAAAGTCAACCTGAAAACTCAACAATCACAGCATCCAACGGATGCTTTATCA
GAAGATCTGCTGAGCATCATTGCAAACATGTCTGGATGTCTCCCTTACATGCTGCCCCCA
AAATGCCCAAACACTTGCCTGGCGAACAAATACAGGCCCATCACAGGAGCTTGCAACAAC
AGAGACCACCCCAGATGGGGCGCCTCCAACACGGCCCTGGCACGATGGCTCCCTCCAGTC
TATGAGGACGGCTTCAGTCAGCCCCGAGGCTGGAACCCCGGCTTCTTGTACAACGGGTTC
CCACTGCCCCCGGTCCGGGAGGTGACAAGACATGTCATTCAAGTTTCAAATGAGGTTGTC
ACAGATGATGACCGCTATTCTGACCTCCTGATGGCATGGGGACAATACATCGACCACGAC
ATCGCGTTCACACCACAGAGCACCAGCAAAGCTGCCTTCGGGGGAGGGGCTGACTGCCAG
ATGACTTGTGAGAACCAAAACCCATGTTTTCCCATACAACTCCCGGAGGAGGCCCGGCCG
GCCGCGGGCACCGCCTGTCTGCCCTTCTACCGCTCTTCGGCCGCCTGCGGCACCGGGGAC
CAAGGCGCGCTCTTTGGGAACCTGTCCACGGCCAACCCGCGGCAGCAGATGAACGGGTTG
ACCTCGTTCCTGGACGCGTCCACCGTGTATGGCAGCTCCCCGGCCCTAGAGAGGCAGCTG
CGGAACTGGACCAGTGCCGAAGGGCTGCTCCGCGTCCACGCGCGCCTCCGGGACTCCGGC
CGCGCCTACCTGCCCTTCGTGCCGCCACGGCGGCCTGCGGCCTGTGCGCCCGAGCCCGGC
ATCCCCGGAGAGACCCGCGGGCCCTGCTTCCTGGCCGGAGACGGCCGCGCCAGCGAGGTC
CCCTCCCTGACGGCACTGCACACGCTGTGGCTGCGCGAGCACAACCGCCTGGCCGCGGCG
CTCAAGGCCCTCAATGCGCACTGGAGCGCGGACGCCGTGTACCAGGAGGCGCGCAAGGTC
GTGGGCGCTCTGCACCAGATCATCACCCTGAGGGATTACATCCCCAGGATCCTGGGACCC
GAGGCCTTCCAGCAGTACGTGGGTCCCTATGAAGGCTATGACTCCACCGCCAACCCCACT
GTGTCCAACGTGTTCTCCACAGCCGCCTTCCGCTTCGGCCATGCCACGATCCACCCGCTG
GTGAGGAGGCTGGACGCCAGCTTCCAGGAGCACCCCGACCTGCCCGGGCTGTGGCTGCAC
CAGGCTTTCTTCAGCCCATGGACATTACTCCGTGGAGGTGGTTTGGACCCACTAATACGA
GGCCTTCTTGCAAGACCAGCCAAACTGCAGGTGCAGGATCAGCTGATGAACGAGGAGCTG
ACGGAAAGGCTCTTTGTGCTGTCCAATTCCAGCACCTTGGATCTGGCGTCCATCAACCTG
CAGAGGGGCCGGGACCACGGGCTGCCAGGTTACAATGAGTGGAGGGAGTTCTGCGGCCTG
CCTCGCCTGGAGACCCCCGCTGACCTGAGCACAGCCATCGCCAGCAGGAGCGTGGCCGAC
AAGATCCTGGACTTGTACAAGCATCCTGACAACATCGATGTCTGGCTGGGAGGCTTAGCT
GAAAACTTCCTCCCCAGGGCTCGGACAGGGCCCCTGTTTGCCTGTCTCATTGGGAAGCAG
ATGAAGGCTCTGCGGGATGGTGACTGGTTTTGGTGGGAGAACAGCCACGTCTTCACGGAT
GCACAGAGGCGTGAGCTGGAGAAGCACTCCCTGTCTCGGGTCATCTGTGACAACACTGGC
CTCACCAGGGTGCCCATGGATGCCTTCCAAGTCGGCAAATTCCCTGAAGACTTTGAGTCT
TGTGACAGCATCCCTGGCATGAACCTGGAGGCCTGGAGGGAAACCTTTCCTCAAGACGAC
AAGTGTGGCTTCCCAGAGAGCGTGGAGAATGGGGACTTTGTGCACTGTGAGGAGTCTGGG
AGGCGCGTGCTGGTGTATTCCTGCCGGCACGGGTATGAGCTCCAAGGCCGGGAGCAGCTC
ACTTGCACCCAGGAAGGATGGGATTTCCAGCCTCCCCTCTGCAAAGATGTGAACGAGTGT
GCAGACGGTGCCCACCCCCCCTGCCACGCCTCTGCGAGGTGCAGAAACACCAAAGGCGGC
TTCCAGTGTCTCTGCGCGGACCCCTACGAGTTAGGAGACGATGGGAGAACCTGCGTAGAC
TCCGGGAGGCTCCCTCGGGCGACTTGGATCTCCATGTCGCTGGCTGCTCTGCTGATCGGA
GGCTTCGCAGGTCTCACCTCGACGGTGATTTGCAGGTGGACACGCACTGGCACTAAATCC
ACACTGCCCATCTCGGAGACAGGCGGAGGAACTCCCGAGCTGAGATGCGGAAAGCACCAG
GCCGTAGGGACCTCACCGCAGCGGGCCGCAGCTCAGGACTCGGAGCAGGAGAGTGCTGGG
ATGGAAGGCCGGGATACTCACAGGCTGCCGAGAGCCCTCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
J02969

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p25

# Metabolic_Enzyme_1_SNPs:
rs2175977; rs13431173; rs732609; rs4927611; rs1126799; rs10189135; rs1042589; rs2280132; rs28915688; rs28991293; rs28913014; rs732608; rs13429240; rs17091745; rs28915689; rs28909989; rs28910597; rs9678281; rs17415659; rs2071403; rs9326166; rs9326167; rs17091628; rs28909986; rs28909987; rs2009364; rs1464083; rs1514686; rs1464086; rs2048726; rs2048722; rs961028; rs1965406; rs2048721; rs1514682; rs1877854; rs6715129; rs7602540; rs949835; rs938330; rs9679017; rs6706775; rs9751670; rs10198697; rs1399390; rs11211650; rs2070878; rs13424221; rs1399387; rs10172186; rs10206727; rs11694817; rs3755554; rs6588672; rs10165715; rs10208730; rs9326170; rs4927624; rs4927612; rs2070879; rs4278970; rs4927619; rs13430369; rs13413321; rs2276702; rs6716111; rs2175978; rs10204647; rs1877855; rs7583792; rs6717381; rs4927615; rs2280129; rs7598233; rs6711545; rs11891272; rs13425669; rs11886972; rs7596885; rs6716250; rs11211651; rs6732480; rs9679267; rs6747390; rs6588665; rs867983; rs9326169; rs11896517; rs1464085; rs11888851; rs6708496; rs7602332; rs10170919; rs2361754; rs1464084; rs6714887; rs6759960; rs1514688; rs2090154; rs1913584; rs6708273; rs10204515; rs3755555; rs11888196; rs10201842; rs6711901; rs938327; rs2138018; rs1567918; rs6760043; rs10171105; rs2138019; rs4927610; rs6752121; rs10205811; rs11211654; rs6740728; rs10189329; rs6727192; rs2070881; rs1965405; rs6588664; rs1473936; rs10177597; rs11897437; rs1967512; rs2885361; rs2361748; rs4927631; rs1514687; rs11690515; rs11904276; rs950675; rs6588669; rs10169429; rs4927621; rs11896057; rs6588674; rs11691841; rs6588673; rs10197874; rs9678469; rs9751407; rs4927608; rs2014911; rs6723319; rs1399389; rs4927580; rs10205420; rs11897713; rs2885362; rs11211653; rs2070882; rs9750182; rs6588663; rs12615819; rs4927578; rs10174000; rs13386909; rs6754104; rs17732233; rs6718027; rs11891867; rs13393765; rs11211649; rs10193983; rs13398180; rs4927574; rs11687944; rs9973690; rs2280131; rs7574221; rs12465127; rs11675388; rs10200413; rs10167570; rs13412229; rs6588676; rs13429459; rs3755549; rs12328748; rs13427125; rs28361468; rs9326171; rs3834179; rs3755548; rs4359704; rs2361767; rs10188260; rs11694726; rs17091772; rs10165832; rs949834; rs11674560; rs4927581; rs7424680; rs3796122; rs13412980; rs17731349; rs9677050; rs4927606; rs13431646; rs13415674; rs949833; rs4927593; rs4927585; rs4600709; rs1514685; rs4328675; rs4927591; rs17731324; rs4425120; rs11899801; rs10495482; rs4927589; rs2070877; rs4927632; rs2070880; rs2048727; rs2276701; rs12619427; rs13431898; rs3755550; rs10519477; rs12472829; rs6588671; rs10170270; rs13405352; rs1976692; rs10189437; rs3772076; rs3772075; rs6588667; rs11683914; rs11211647; rs4481033; rs13431282; rs2276704; rs11691963; rs11891228; rs10166929; rs2280128; rs10190245; rs6588675; rs4927590; rs13414566; rs2361750; rs10196514; rs1514684; rs4592894; rs3772074; rs4927579; rs28663288; rs6588670; rs11211652; rs7355479; rs11692536; rs13409391; rs12470856; rs3755551; rs10181072; rs11691145; rs13405477; rs17091682; rs11682961; rs6712430; rs11897718; rs10194040; rs10207656; rs11681087; rs11211646; rs17091633; rs13400150; rs4927575; rs949832; rs1969248; rs17091667; rs13418264; rs7564759; rs1818525; rs13392535; rs11689536; rs11896906; rs17091737; rs3755553; rs3755552; rs12478431; rs4927617; rs6751783; rs9326172; rs1514683; rs11887707; rs938328; rs6588678; rs17091744; rs2048724; rs11211655; rs2007268; rs28913037; rs28909998; rs13409815; rs10890518; rs28910600; rs28912368; rs11886764; rs28913007; rs28910585; rs28912975; rs28910579; rs7607582; rs28912989; rs9326168; rs28911496; rs28991288; rs28913033; rs28910603; rs28910595; rs28915678; rs28909396; rs28909371; rs9798488; rs28912994; rs11904640; rs12616671; rs28911471; rs28909384; rs28913016; rs28991294; rs28912972; rs13016763; rs12471358; rs28991276; rs28909999; rs13422969; rs11675177; rs28911488; rs28909393; rs28915676; rs28912991; rs4927607; rs28910607; rs6588668; rs4927614; rs12471599; rs11685779; rs28910000; rs28913029; rs28909401; rs28910568; rs28991269; rs28912974; rs11686432; rs11674407; rs28910591; rs28991283; rs4927586; rs28913003; rs2361744; rs2138020; rs4927592; rs28991290; rs28915672; rs28909379; rs28909400; rs29001651; rs28911495; rs28911485; rs28909994; rs28909372; rs28911492; rs4927594; rs28910575; rs10181280; rs28911481; rs11695695; rs28910578; rs28913271; rs28909415; rs4927622; rs28909397; rs28913022; rs11678545; rs28909390; rs28911170; rs28910007; rs11899018; rs28915677; rs28910594; rs28911470; rs9677934; rs12328533; rs28915670; rs28991273; rs17732056; rs28911475; rs28913008; rs9677308; rs28910586; rs28910606; rs28909380; rs28912992; rs28909402; rs28910574; rs9678767; rs6711500; rs28911487; rs28913023; rs28915684; rs4927577; rs13391992; rs28909411; rs11211648; rs11685540; rs28913275; rs28912969; rs28913030; rs28915673; rs28991277; rs28909407; rs28909387; rs28909993; rs28911480; rs4567992; rs28911171; rs13394978; rs28911493; rs28913041; rs11885587; rs28910583; rs28913270; rs28912999; rs2138017; rs10197546; rs28991289; rs4927628; rs9678341; rs28913004; rs28911478; rs28910013; rs28912996; rs10205550; rs28910599; rs13391557; rs28909391; rs28915680; rs4927582; rs4927625; rs17731501; rs13409953; rs11676827; rs13418570; rs11683140; rs9677680; rs13394194; rs28913013; rs28912985; rs11889947; rs28912981; rs1113829; rs4927584; rs10207591; rs28912980; rs2048725; rs28913274; rs4927613; rs28991274; rs28913011; rs28910005; rs28910002; rs9678972; rs13016765; rs17091706; rs28909403; rs28991281; rs28910605; rs28909383; rs28913273; rs28913017; rs28913024; rs13410529; rs7591179; rs28910611; rs28909394; rs28915685; rs28910580; rs11899974; rs12468041; rs11690402; rs28909368; rs28915674; rs28909373; rs28912998; rs28913009; rs28913039; rs28911175; rs28913035; rs17091666; rs28911490; rs28991270; rs28910577; rs28909992; rs28910001; rs28911172; rs28912984; rs4927588; rs28910571; rs28910010; rs4425119; rs28909389; rs28913028; rs13399844; rs4314036; rs12621034; rs4927609; rs28915668; rs4645041; rs13426289; rs4927616; rs28910609; rs28912988; rs28913040; rs11687912; rs28991285; rs28910573; rs28910584; rs28913020; rs28911476; rs28910602; rs28913005; rs6588666; rs11676091; rs28913031; rs10204402; rs28913001; rs28909668; rs28911483; rs28911473; rs28909374; rs28911468; rs13430623; rs28909386; rs28991271; rs28909382; rs28913021; rs12328004; rs28910576; rs11695385; rs1965407; rs28910601; rs28909990; rs4629198; rs28912993; rs10193135; rs28913010; rs28911173; rs28912977; rs7568087; rs28910014; rs1828865; rs12718450; rs28911491; rs11674711; rs28911168; rs4927587; rs28909991; rs28910581; rs28910610; rs28909395; rs4927583; rs28913018; rs1567919; rs28912971; rs28913036; rs28991275; rs28913042; rs28915675; rs28991287; rs28910588; rs28991278; rs961029; rs28912990; rs28913019; rs1567917; rs28910608; rs28909408; rs28912987; rs28909375; rs28915669; rs28912970; rs28909385; rs7597945; rs28991272; rs28913269; rs11676046; rs28909392; rs28909414; rs28909388; rs28910011; rs28912983; rs12105374; rs28991279; rs4404322; rs28915671; rs28911482; rs12613496; rs13431561; rs4927630; rs28913272; rs28912973; rs28911469; rs28911472; rs28909399; rs28913006; rs28911494; rs28910572; rs11690812; rs13415386; rs2071399; rs2280126; rs2298876; rs2071402; rs2071401; rs4927604; rs2280127; rs2071400; rs28991568; rs28915690; rs28909983; rs2298875; rs28910612; rs28991292; rs17855780; rs28915687; rs28910598; rs3732349; rs35105246; rs13407655; rs28909988; rs28915683; rs10536458; rs35505969; rs12474694; rs6755275; rs10180652; rs12993998; rs33961599; rs28909381; rs28360867; rs4927627; rs11681539; rs13410524; rs13383329; rs28912968; rs13415459; rs9973956; rs35756267; rs28909376; rs35523187; rs2048723; rs28630635; rs13031189; rs28911174; rs28633865; rs28909410; rs10629723; rs28909378; rs11677995; rs34132009; rs13413324; rs28911474; rs28910590; rs12994019; rs34920078; rs13000154; rs13000160; rs35605249; rs10166153; rs35043612; rs10666298; rs13026152; rs2885358; rs33990262; rs28910604; rs28910582; rs11688703; rs34374057; rs28912978; rs10176490; rs28915686; rs34413546; rs28632119; rs35225495; rs13430142; rs35431867; rs12987712; rs28460424; rs35944967; rs10184056; rs35732856; rs35531860; rs36119335; rs13396955; rs28909406; rs13020227; rs10203030; rs12612745; rs11689344; rs28912982; rs10206512; rs28912986; rs7369446; rs11686894; rs28909997; rs12986996; rs11691839; rs13035669; rs28580848; rs13006856; rs13385085; rs13415301; rs3831487; rs10190227; rs11686114; rs28912995; rs12616672; rs11412726; rs28915679; rs35725026; rs28672357; rs35893094; rs28910012; rs12476324; rs10608158; rs28874626; rs28909369; rs28464331; rs28445930; rs12986956; rs28913038; rs28991280; rs34191654; rs28665837; rs12478638; rs1399391; rs11688366; rs13006647; rs28910003; rs13036149; rs6705010; rs28671559; rs35708755; rs2280130; rs13410383; rs13393048; rs28909412; rs13430024; rs28912979; rs13382606; rs10193732; rs10573336; rs34043302; rs9677153; rs35874586; rs13382789; rs28437604; rs11678127; rs13430374; rs36220342; rs13397445; rs35553172; rs34128932; rs28911484; rs28991284; rs13431558; rs11687959; rs12105080; rs28991268; rs13027675; rs13000139; rs28651176; rs11687787; rs35908928; rs10208039; rs28913000; rs28729219; rs28566655; rs10194736; rs13026377; rs10666299; rs13420584; rs28910006; rs9677433; rs13424741; rs10184419; rs34359520; rs35103896; rs34099200; rs28909996; rs28433376; rs11904785; rs5828821; rs28909377; rs12612565; rs11272722; rs13392954; rs35752553; rs35208164; rs28378083; rs34080455; rs28913012; rs28636451; rs11272011; rs12992674; rs11412725; rs28435455; rs35700910; rs35500489; rs35104320; rs35727441; rs34796953; rs7369268; rs7368786; rs28591627; rs28420122; rs35584537; rs11691743; rs35123035; rs34032155; rs28910008; rs4927605; rs2885360; rs3036100; rs28910587; rs34933514; rs28911486; rs2090153; rs34445751; rs11404899; rs35682038; rs4927629; rs35388919; rs34044289; rs11898092; rs12475212; rs28683616; rs28409666; rs11893496; rs3036105; rs2175979; rs28909413; rs35858346; rs28913268; rs34602774; rs34131144; rs3036079; rs4927620; rs28682482; rs13409826; rs35614838; rs34480829; rs12992385; rs28911479; rs28913025; rs35623494; rs28909995; rs36175402; rs13418129; rs13406835; rs34046827; rs28915681; rs11687965; rs35008230; rs13006236; rs5828824; rs34879368; rs28911169; rs9973952; rs13417585; rs28912976; rs13010957; rs9973955; rs13020631; rs35943116; rs28909398; rs13423107; rs28461932; rs13012709; rs28910593; rs13423282; rs4927596; rs13014527; rs10191653; rs34064729; rs11673992; rs9750163; rs9677530; rs28909404; rs4927626; rs13404230; rs7583423; rs28910569; rs35290486; rs2361747; rs13006630; rs10181396; rs9973911; rs28991282; rs28915682; rs28911489; rs28437028; rs5828823; rs28681289; rs13404488; rs28912997; rs10170298; rs28913015; rs13014542; rs13385523; rs13027419; rs11689386; rs35839340; rs13036125; rs28910009; rs34541512; rs34790485; rs28677046; rs28910596; rs34413535; rs34531889; rs28909370; rs11687810; rs9679416; rs34950864; rs2203399; rs34932469; rs10523977; rs11673953; rs34234148; rs12986550; rs28620935; rs2090152; rs13026363; rs28909409; rs28913026; rs28489465; rs35201002; rs13403910; rs34521796; rs28913027; rs11887001; rs35836927; rs28432167; rs10197112; rs28910592; rs28910570; rs7579188; rs34088587; rs11371261; rs13402950; rs12476325; rs12151527; rs28913002; rs4927595; rs10634971; rs35224341; rs35631326; rs13403265; rs2885359; rs28911477; rs13000185; rs28991286; rs28910004; rs11673934; rs28909405; rs13031191; rs28913032; rs28991291; rs28909985; rs28991569; rs35374888; rs10179394; rs28909984; rs13407296; rs10192959; rs10202105; rs10206900; rs10890517; rs11211645; rs11675342; rs11675434; rs11678852; rs11681698; rs11682968; rs11685159; rs11686524; rs11686775; rs11694732; rs12469603; rs12471910; rs12990372; rs13017252; rs13390616; rs13400534; rs13407974; rs13413096; rs13413987; rs13414537; rs13426896; rs1567920; rs17091606; rs17091611; rs17091616; rs17786733; rs1828864; rs2298873; rs2298874; rs35743195; rs6605278; rs6705087; rs9677074

# Metabolic_Enzyme_1_General_References:
3475693; 3453124; 2548579; 2308857; 12454013; 3654979; 2383265; 7550241; 9024270; 10468986; 10084596; 9924196; 11061528; 11415848; 11916616; 12213873; 11874711; 12938097

# Metabolic_Enzyme_1_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7546

# Macromolecular_Interacting_Partner_1_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
PRL

# Macromolecular_Interacting_Partner_1_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_1_Signals:
1-28

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_1_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_1_References:
6127069

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
11048659; 11945437; 6758860; 7009145

# Macromolecular_Interacting_Partner_3_ID:
7975

# Macromolecular_Interacting_Partner_3_Name:
Tyrosine 3-monooxygenase

# Macromolecular_Interacting_Partner_3_Synonyms:
Tyrosine 3-hydroxylase; TH

# Macromolecular_Interacting_Partner_3_Gene_Name:
TH

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
528

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
58525

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Macromolecular_Interacting_Partner_3_Pathway:
map00350  Tyrosine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00351:Biopterin_H

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 1.14.16.2

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
37127

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
TY3H_HUMAN (P07101)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
TH

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
TH

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:11782

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
Y00414

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Macromolecular_Interacting_Partner_3_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Macromolecular_Interacting_Partner_3_References:
11696250; 2110978; 2896667

# Macromolecular_Interacting_Partner_4_ID:
8304

# Macromolecular_Interacting_Partner_4_Name:
Thyroglobulin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
TG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Thyroglobulin precursor
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQT
VQCQNDGRSCWCVGANGSEVLGSRQPGRPVACLSFCQLQKQQILLSGYINSTDTSYLPQC
QDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADS
QGRELAETGLELLLDEIYDTIFAGLDLPSTFTETTLYRILQRRFLAVQSVISGRFRCPTK
CEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSG
LLRPMVEGQSQQFSVSENLLKEAIRAIFPSRGLARLALQFTTNPKRLQQNLFGGKFLVNV
GQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVME
TVLSSQTCEQTPERLFVPSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPT
DCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQ
VFELYQRWEAQNKGQDLTPAKLLVKIMSYREAASGNFSLFIQSLYEAGQQDVFPVLSQYP
SLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVA
KGIRLRNEDLGLPPLFPPREAFAEQFLRGSDYAIRLAAQSTLSFYQRRRFSPDDSAGASA
LLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSS
SSAQCPSLCNVLKSGVLSRRVSPGYVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPG
TRVTGGQPACESPRCPLPFNASEVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPG
PLICSLESGRWESQLPQPRACQRPQLWQTIQTQGHFQLQLPPGKMCSADYADLLQTFQVF
ILDELTARGFCQIQVKTFGTLVSIPVCNNSSVQVGCLTRERLGVNVTWKSRLEDIPVASL
PDLHDIERALVGKDLLGRFTDLIQSGSFQLHLDSKTFPAETIRFLQGDHFGTSPRTWFGC
SEGFYQVLTSEASQDGLGCVKCPEGSYSQDEECIPCPVGFYQEQAGSLACVPCPVGRTTI
SAGAFSQTHCVTDCQRNEAGLQCDQNGQYRASQKDRGSGKAFCVDGEGRRLPWWETEAPL
EDSQCLMMQKFEKVPESKVIFDANAPVAVRSKVPDSEFPVMQCLTDCTEDEACSFFTVST
TEPEISCDFYAWTSDNVACMTSDQKRDALGNSKATSFGSLRCQVKVRSHGQDSPAVYLKK
GQGSTTTLQKRFEPTGFQNMLSGLYNPIVFSASGANLTDAHLFCLLACDRDLCCDGFVLT
QVQGGAIICGLLSSPSVLLCNVKDWMDPSEAWANATCPGVTYDQESHQVILRLGDQEFIK
SLTPLEGTQDTFTNFQQVYLWKDSDMGSRPESMGCRKDTVPRPASPTEAGLTTELFSPVD
LNQVIVNGNQSLSSQKHWLFKHLFSAQQANLWCLSRCVQEHSFCQLAEITESASLYFTCT
LYPEAQVCDDIMESNAQGCRLILPQMPKALFRKKVILEDKVKNFYTRLPFQKLMGISIRN
KVPMSEKSISNGFFECERRCDADPCCTGFGFLNVSQLKGGEVTCLTLNSLGIQMCSEENG
GAWRILDCGSPDIEVHTYPFGWYQKPIAQNNAPSFCPLVVLPSLTEKVSLDSWQSLALSS
VVVDPSIRHFDVAHVSTAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADT
QSCTHSLQGQNCRLLLREEATHIYRKPGISLLSYEASVPSVPISTHGRLLGRSQAIQVGT
SWKQVDQFLGVPYAAPPLAERRFQAPEPLNWTGSWDASKPRASCWQPGTRTSTSPGVSED
CLYLNVFIPQNVAPNASVLVFFHNTMDREESEGWPAIDGSFLAAVGNLIVVTASYRVGVF
GFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTAR
ATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVVSCLRQKPAN
VLNDAQTKLLAVSGPFHYWGPVIDGHFLREPPARALKRSLWVEVDLLIGSSQDDGLINRA
KAVKQFEESRGRTSSKTAFYQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRAL
ENATRDYFIICPIIDMASAWAKRARGNVFMYHAPENYGHGSLELLADVQFALGLPFYPAY
EGQFSLEEKSLSLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEF
SELLPNRQGLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEELTAGSGLREDLLSLQE
PGSKTYSK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
2768

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
304792

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.26

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_4_Specific_Function:
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00135:COesterase;
PF07699:GCC2_GCC3;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_4_Signals:
1-19

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
37174

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
THYG_HUMAN (P01266)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11764

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>8304 bp
ATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAAT
ATCTTCGAGTACCAGGTTGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACG
GCCTTTCTGAAGCAAGCAGACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACT
GTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTG
CTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAA
CAGCAGATCTTACTGAGTGGCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGT
CAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCATGTCCAGTGCTGGTGT
GTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGT
CCAAGGAGCTGTGAAATAAGAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCA
CCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACA
GACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACC
TTCAGTTCCTTCCAGAGGAGGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGC
CAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACC
ATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTG
CAGAGACGGTTCCTCGCAGTTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAA
TGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGC
CGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGAC
GCCCAGGGGAAGGAAATGCATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAA
GGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCA
GGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGA
GTAGCCAGATTTGCCACATCCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGG
CTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTC
AAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTT
ACCACCAACCCAAAGAGACTCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTT
GGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTT
TTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAG
CCACTCTCTGTGGGATTAGATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAG
GATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAG
AACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTC
TTGCAACATGCTATCTCTGTGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAA
ACGGTACTCGACTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGC
ACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAAT
TCCTGGGGCAAAGAGCTTCCAGGCTCAAGAGTCAGAGATGGACAGCCAAGGTGCCCCACA
GACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCC
ACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAAC
TCAGAGTGCTACTGTGTTGATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATA
GGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGG
ACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATC
CCACAGTGCAGCACCGATGGGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAG
GTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCC
AAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTT
ATTCAAAGTCTGTATGAGGCTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCT
TCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAAT
ATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCG
GGGTCCTACTCAGACTTCAGCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGT
GTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACG
TGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAA
GAGATTGTTTCAGCTTCCAACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCC
AAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAG
GCTTTCGCGGAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACC
TTAAGCTTCTATCAGAGACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTT
CTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTGCAG
TGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGC
TCACTGACTGCCCGCTCTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGA
ACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCAAAA
GACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAATATGCCAGGCTGCAGGCATCGGGG
GCTGGCACCTGGTGTGTGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGC
AGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCTCTCTAGGAGAGTC
AGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGT
GACCAGGCCCAGGGCAGCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACG
CGCGTGACCGGGGGCCAGCCCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAACGCG
TCGGAGGTGGTTGGTGGAACAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCTGCC
ATGCAGCAGTGCCAATTGCTGTGCCGCCAAGGCTCCTGGAGCGTGTTTCCACCAGGGCCA
TTGATATGTAGCCTGGAGAGCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCCTGC
CAACGGCCCCAGCTGTGGCAGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTCCCG
CCGGGCAAGATGTGCAGTGCTGACTACGCGGGTTTGCTGCAGACTTTCCAGGTTTTCATA
TTGGATGAGCTGACAGCCCGCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACCCTG
GTTTCCATTCCTGTCTGCAACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGT
TTAGGAGTGAATGTTACATGGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTTCCT
GACTTACATGACATTGAGAGAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGAT
CTGATCCAGAGTGGCTCATTCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACC
ATCCGCTTCCTCCAAGGGGACCACTTTGGCACCTCTCCTAGGACACGGTTTGGGTGCTCG
GAAGGATTCTACCAAGTCTTGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAG
TGCCATGAAGGAAGCTATTCCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTAC
CAAGAACAGGCAGGGAGCTTGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATTTCT
GCCGGAGCTTTCAGCCAGACTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTG
CAATGTGACCAGAATGGCCAGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCC
TTCTGTGTGGACGGCGAGGGGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTTGAG
GACTCACAGTGTTTGATGATGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTC
GACGCCAATGCTCCTGTGGCTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATG
CAGTGCTTGACAGATTGCACAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACGACG
GAGCCAGAGATTTCCTGTGATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACT
TCTGACCAGAAACGAGATGCACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGC
TGCCAGGTGAAAGTGAGGAGCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAGGGC
CAAGGATCCACCACAACACTTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTT
TCTGGATTGTACAACCCCATTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCAC
CTCTTCTGTCTTCTTGCATGCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACACAG
GTTCAAGGAGGTGCCATCATCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAAT
GTCAAAGACTGGATGGATCCCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACA
TATGACCAGGAGAGCCACCAGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAGAGT
CTGACACCCTTAGAAGGAACTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGG
AAAGATTCTGACATGGGGTCTCGGCCTGAGTCTATGGGATGTAGAAAAAACACAGTGCCA
AGGCCAGCATCTCCAACAGAAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGACCTC
AACCAGGTCATTGTCAATGGAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAG
CACCTGTTTTCAGCCCAGCAGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCAC
TCTTTCTGTCAGCTCGCAGAGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACCCTC
TACCCAGAGGCACAGGTGTGTGATGACATCATGGAGTCCAATACCCAGGGCTGCAGACTG
ATCCTGCCTCAGATGCCAAAGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTG
AAGAACTTTTACACTCGCCTGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAATAAA
GTGCCCATGTCTGAAAAATCTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGAT
GCGGACCCATGCTGCACTGGCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAG
GTGACATGTCTCACTCTGAACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGAGGA
GCCTGGCGCATTTTGGACTGTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGA
TGGTACCAGAAGCCCATTGCTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTG
CCTTCCCTCACAGAGAAAGTGTCTCTGGAATCGTGGCAGTCCCTGGCCCTCTCTTCAGTG
GTTGTTGATCCATCCATTAGGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGC
AATTTCTCTGCTGTCCGAGACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTC
ATCACCACTCTGCAAACCCAACTCGGGGCTGTGAGATGTATGTTCTATGCTGATACTCAA
AGCTGCACACATAGTCTGCAGGGTCGGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACC
CACATCTACCGGAAGCCAGGAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTG
CCCATTTCCACCCATGGCCGGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACCTCA
TGGAAGCAAGTGGACCAGTTCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGG
CACTTCCAGGCACCAGAGCCCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGG
GCCAGCTGCTGGCAGCCAGGCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGATTGT
TTGTATCTCAATGTGTTCATCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTC
TTCCACAACACCATGGACAGGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTC
TTGGCTGCTGTTGGCAACCTCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTCGGC
TTCCTGAGTTCTGGATCCGGAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCG
GCTCTGACCTGGGTGCAGACCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCC
CTGGCAGCAGACCGTGGCGGGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGGGCC
ACCAACTCCCAACTTTTCCGGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCC
GCCGTCATCAGCCATGAGAGGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGT
TGCCCCATGTCATCCAGCCAAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTC
CTCAATGATGCCCAGACCAAGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCT
GTGATCGATGGCCACTTCCTCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGG
GTAGAGGTCGATCTGCTCATTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAG
GCTGTGAAGCAATTTGAGGAAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAG
GCACTGCAGAATTCTCTGGGTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACA
TGGTATTACTCTCTGGAGCACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAG
AATGCCACCCGGGACTACTTTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCA
AAGAGGGCCCGAGGAAACGTCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGC
CTGGAGCTGCTGGCGGATGTTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAG
GGGCAGTTTTCTCTGGAGGAGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCAC
TTCATCAGATCAGGAAATCCCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTT
GCAACCCCCTGGCCTGACTTTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGT
GAGCTGCTCCCCAATCGACAGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTAC
ATCTCGTCTCTGAAGACATCTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAA
GAGGAGGAGTTGACGGCTGGATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCA
GGCTCTAAGACCTACAGCAAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X05615

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_4_Locus:
8q24

# Macromolecular_Interacting_Partner_4_SNPs:
rs853326; rs2069561; rs1133076; rs10091530; rs180222; rs11535853; rs16893332; rs180223; rs12549018; rs2272707; rs3739274; rs2069548; rs11992497; rs2229843; rs16904774; rs2069550; rs2294024; rs853304; rs2228590; rs16904799; rs2294003; rs17693031; rs2069568; rs16904786; rs2250927; rs2741217; rs940075; rs2741228; rs2739075; rs853303; rs2979022; rs2703006; rs866468; rs2702988; rs180211; rs2140296; rs2739143; rs2403882; rs2687810; rs2739156; rs2739060; rs2703010; rs2204208; rs2246625; rs1523072; rs2248346; rs2739169; rs2741216; rs1357452; rs1474539; rs1000264; rs2244718; rs2739152; rs2687807; rs870685; rs1403481; rs879810; rs2739142; rs2739061; rs2248574; rs2979029; rs2703005; rs873177; rs2702987; rs2142378; rs2739079; rs2246608; rs2979025; rs2687815; rs2739054; rs2979051; rs2687808; rs712054; rs2741209; rs2249869; rs2741223; rs2741205; rs2741210; rs871162; rs2739141; rs2979048; rs2739180; rs885113; rs2741222; rs870539; rs1403480; rs2958670; rs2140295; rs2979020; rs2739071; rs2687834; rs864898; rs2741208; rs2403910; rs2739069; rs2741218; rs2739073; rs2739078; rs2741225; rs853321; rs2687827; rs2702974; rs909359; rs2741211; rs180210; rs2205452; rs2703011; rs876902; rs2958668; rs2741221; rs2142383; rs180208; rs2739148; rs853298; rs872286; rs2739154; rs2245152; rs2979030; rs2703008; rs1523067; rs6988528; rs2005162; rs2958693; rs940074; rs909361; rs2739165; rs2739151; rs2979032; rs4736622; rs6984038; rs6984052; rs6994110; rs2896692; rs6985454; rs11785557; rs1403487; rs4736625; rs4736613; rs2739166; rs13264468; rs2702999; rs1916274; rs4443645; rs2739155; rs2958688; rs885196; rs3847174; rs4336595; rs6990835; rs4736628; rs2037540; rs7818360; rs6471107; rs712055; rs180202; rs4551333; rs10105992; rs4403389; rs4585737; rs2739057; rs7018140; rs4736432; rs3758113; rs868508; rs10106820; rs2739074; rs4478553; rs2702991; rs2103069; rs885195; rs853318; rs2979035; rs2687813; rs853300; rs2958694; rs10113099; rs872643; rs2703013; rs860471; rs4736626; rs7009823; rs2294025; rs7846474; rs2741213; rs180212; rs872285; rs4540390; rs6982788; rs2739161; rs2958677; rs12545138; rs1403485; rs871402; rs1474540; rs10091983; rs1916275; rs6998833; rs7844761; rs10105189; rs4736433; rs869769; rs2958681; rs2739159; rs1033363; rs853296; rs2958674; rs4236897; rs7844649; rs2687843; rs7827903; rs12541260; rs2739058; rs7832522; rs2272706; rs7015412; rs2177296; rs4236895; rs7829428; rs6990302; rs2091036; rs11785901; rs2256476; rs2979034; rs7827937; rs2739149; rs1523070; rs2261147; rs2958686; rs7827533; rs4736624; rs7825913; rs1533909; rs9297863; rs2958671; rs180213; rs11782322; rs2703004; rs11782262; rs1806535; rs2140297; rs4736623; rs10088449; rs2739177; rs2177297; rs2687822; rs6471109; rs2687819; rs2068128; rs6998423; rs853306; rs4736430; rs6981042; rs2703009; rs1403484; rs180217; rs885194; rs180204; rs2739162; rs7814048; rs2703007; rs2739171; rs2403883; rs2248578; rs2958684; rs4612318; rs4736616; rs11776724; rs7845084; rs1879991; rs2958679; rs7823628; rs4301434; rs7000428; rs9297865; rs4278132; rs7844859; rs940073; rs6999702; rs3161; rs1851571; rs2958687; rs951452; rs7844210; rs2687818; rs7817693; rs7824618; rs11782282; rs4736429; rs2958680; rs4601289; rs865488; rs4736431; rs2739163; rs10095925; rs11784620; rs6471111; rs940078; rs1403488; rs2958683; rs7828146; rs2739070; rs2979027; rs2687831; rs9969622; rs10088696; rs1033361; rs1000263; rs853322; rs2739065; rs6994911; rs4074676; rs2244715; rs2293210; rs11785501; rs11786982; rs872644; rs6992986; rs11990839; rs2741212; rs853308; rs2702973; rs17630941; rs1403491; rs1879992; rs2142379; rs1403483; rs926174; rs2702994; rs16904790; rs6981934; rs6993250; rs2958692; rs4548165; rs16904836; rs17702843; rs12679617; rs180219; rs180207; rs862503; rs2687809; rs16904775; rs853297; rs4377944; rs11777992; rs12545159; rs2739064; rs4363178; rs2739053; rs2142384; rs2687832; rs2739170; rs10100520; rs16904796; rs6471112; rs2687828; rs2222452; rs11782027; rs2687824; rs4736629; rs180206; rs3779948; rs3847173; rs16904832; rs10108988; rs869767; rs865909; rs2248331; rs2687830; rs16904802; rs10103821; rs853323; rs11991061; rs3992996; rs2739157; rs6471108; rs16904768; rs10435562; rs17703832; rs1403482; rs11780642; rs12677246; rs10106670; rs13251221; rs853309; rs4388441; rs4236898; rs2142380; rs3779966; rs10097042; rs853319; rs7011493; rs7008436; rs10505603; rs7818576; rs2979021; rs7815657; rs6997874; rs2245562; rs853305; rs2703002; rs16904784; rs13279688; rs2687829; rs1403486; rs10956686; rs864897; rs13254463; rs10102602; rs2979018; rs11998272; rs2739068; rs2245048; rs16904782; rs879811; rs7827593; rs10088671; rs16904789; rs3892189; rs2687826; rs2958669; rs2258483; rs3739281; rs13263649; rs2739158; rs10105991; rs13256652; rs2461801; rs4297024; rs180221; rs16904762; rs2687825; rs4736434; rs2467991; rs853301; rs1851572; rs2702992; rs4361742; rs11777934; rs3779955; rs2741229; rs2702995; rs180205; rs10505604; rs2741214; rs10106542; rs2739145; rs4273838; rs2142382; rs860474; rs2979049; rs16904794; rs2687812; rs2739139; rs10086069; rs7002393; rs3779951; rs2702989; rs12675044; rs6988193; rs4236899; rs7845804; rs7832064; rs17701982; rs17705719; rs909362; rs1033362; rs16904805; rs11996654; rs2178970; rs2245047; rs2739063; rs2687841; rs2687814; rs4529449; rs11997527; rs2741204; rs9283959; rs7843609; rs2702985; rs7014451; rs2739164; rs2256782; rs853311; rs13265497; rs853302; rs10108422; rs2702979; rs2687846; rs11995141; rs4736435; rs10110664; rs853310; rs2246624; rs12545027; rs1523071; rs7842044; rs2739176; rs10108641; rs11989874; rs4236900; rs2178969; rs11777970; rs2741207; rs2294023; rs2741215; rs16904798; rs7812835; rs11779360; rs853307; rs2702997; rs864091; rs2687845; rs16904806; rs2244716; rs2739072; rs4736627; rs12681531; rs2687833; rs2739168; rs7002366; rs2979033; rs2246611; rs16904778; rs3779949; rs853316; rs2896681; rs1573825; rs4736631; rs2178968; rs2248330; rs12544732; rs2245055; rs2979037; rs581399; rs16904824; rs2979026; rs4736630; rs10092459; rs2687820; rs860473; rs6999594; rs16904801; rs9297864; rs180215; rs3857936; rs2702990; rs2687840; rs17693374; rs13263087; rs11990445; rs10096431; rs10956687; rs16904770; rs2687817; rs16904841; rs4142713; rs16904797; rs10105779; rs6984543; rs16904764; rs7844184; rs9649970; rs10093801; rs4606039; rs16904788; rs34349286; rs2979038; rs11774274; rs16904822; rs11778171; rs2739175; rs2958676; rs2294002; rs9774204; rs2979045; rs12549851; rs16904842; rs2739076; rs7013000; rs2979019; rs12677481; rs16904779; rs13253544; rs16904829; rs7001708; rs7013643; rs4641045; rs10095020; rs17623738; rs16904783; rs909357; rs2958700; rs4430073; rs2739140; rs17613233; rs9969645; rs7836183; rs2256252; rs180216; rs17694217; rs11988147; rs10108459; rs1033360; rs2979036; rs16904825; rs16904781; rs2979040; rs2293999; rs17684629; rs2741227; rs7830370; rs12543039; rs4736633; rs16904771; rs17630799; rs967399; rs2142381; rs16904840; rs733735; rs870540; rs180220; rs11784224; rs2246988; rs9297860; rs11784362; rs16904763; rs16904837; rs17703282; rs16904785; rs7824402; rs860475; rs952346; rs3758114; rs16904776; rs2741206; rs9643296; rs2741226; rs10106416; rs2687842; rs2739062; rs11992894; rs12542426; rs2741219; rs16904767; rs16893339; rs6993411; rs10091720; rs2739077; rs16904769; rs10107048; rs16904803; rs2979028; rs2702978; rs10100508; rs2979039; rs11786334; rs7004655; rs11782801; rs16904833; rs1949729; rs16904773; rs2739066; rs6982276; rs16904772; rs17702000; rs6997296; rs13256826; rs6988394; rs10106773; rs16904792; rs872642; rs16904838; rs16904766; rs2739059; rs1403489; rs10103453; rs16904777; rs4142712; rs10099774; rs1554541; rs2958672; rs17693908; rs10956688; rs6994572; rs17705891; rs17624784; rs2702993; rs1523068; rs2702983; rs17693464; rs2958678; rs17633144; rs2979023; rs872645; rs4736621; rs16904780; rs16904761; rs9774265; rs10096095; rs16904828; rs2739144; rs6988035; rs7845018; rs2687823; rs2008303; rs7014463; rs2294000; rs13256171; rs4736614; rs2056525; rs12334347; rs10098314; rs7843654; rs3892606; rs2703003; rs7000137; rs16904793; rs16904839; rs11995077; rs16904765; rs16904800; rs9969601; rs16904827; rs1810396; rs2739067; rs2403911; rs180193; rs180194; rs999101; rs180195; rs12543299; rs2069546; rs2069565; rs2076737; rs2979042; rs2069566; rs12114109; rs2076738; rs2069558; rs35664324; rs35301433; rs2069562; rs16904791; rs2069557; rs11555531; rs13439368; rs2069555; rs2069554; rs3739269; rs10571; rs2958673; rs13264519; rs34791956; rs35549323; rs41383448; rs11356729; rs36076027; rs5895170; rs28376581; rs2103068; rs7830704; rs35937980; rs35412388; rs35317691; rs1851570; rs34552313; rs28506015; rs36055969; rs10604919; rs34562678; rs4607588; rs11779922; rs12544016; rs35270204; rs35137177; rs34773278; rs34136755; rs3779947; rs1523069; rs1474538; rs7843615; rs35394858; rs6993572; rs34099217; rs34868707; rs12680704; rs34642099; rs36014390; rs35803208; rs12676529; rs5895171; rs7834124; rs13276066; rs34047303; rs16904835; rs12674648; rs11340734; rs34810147; rs34771329; rs7011284; rs11777756; rs35105936; rs10099487; rs34588565; rs34748236; rs34455268; rs10095146; rs33925859; rs2739174; rs2741203; rs34313336; rs5895165; rs10618252; rs7000928; rs35589968; rs869768; rs35486009; rs35061080; rs2958697; rs7826586; rs11783470; rs2702976; rs2702982; rs2741224; rs12335293; rs2739160; rs34413321; rs3958178; rs35473851; rs28659831; rs33960269; rs35664939; rs1882978; rs2979050; rs10536232; rs35313509; rs853315; rs16904817; rs10706012; rs7836320; rs2702984; rs10567770; rs33939827; rs10101897; rs35583800; rs33910321; rs35619992; rs10532987; rs5895164; rs11436640; rs2739179; rs6999184; rs2687844; rs12680666; rs34440378; rs35102598; rs34760590; rs35993480; rs5895169; rs35112762; rs10683644; rs2958703; rs2739147; rs10599394; rs860472; rs2687821; rs13267793; rs35551180; rs1963138; rs2703001; rs34075260; rs34057484; rs28758899; rs28441030; rs6986262; rs34171048; rs28406375; rs28433340; rs6993571; rs34667104; rs34691628; rs35639331; rs879816; rs36065345; rs28405864; rs35468299; rs35606126; rs7460288; rs7011285; rs4316133; rs2958685; rs940076; rs35717199; rs33939013; rs11780782; rs36094625; rs10699743; rs34164866; rs10639956; rs28475483; rs11268257; rs10618253; rs34218497; rs35334722; rs16904818; rs2958698; rs35143972; rs5895166; rs34749093; rs34587713; rs35656634; rs34943147; rs33935978; rs7813333; rs35836924; rs11320050; rs10108500; rs13269733; rs10553390; rs12548839; rs2702981; rs2979044; rs10101716; rs2702977; rs2687835; rs34981034; rs33953992; rs11325505; rs35531314; rs16904804; rs7823660; rs34389272; rs11404754; rs35290286; rs853314; rs35375818; rs28372516; rs11992137; rs33951544; rs3837188; rs34003114; rs34683713; rs35802760; rs35601099; rs35663551; rs34907891; rs2979041; rs34323965; rs11394917; rs12680647; rs3946466; rs5895175; rs2958702; rs2739146; rs34657175; rs7844893; rs1882979; rs35758143; rs6995181; rs5895168; rs34384392; rs36011461; rs2293998; rs10539476; rs11780113; rs13249946; rs2739178; rs180201; rs35336483; rs10532986; rs17621034; rs2739150; rs34016052; rs34726287; rs1134547; rs35340418; rs28697159; rs4736617; rs3992995; rs34362315; rs7841083; rs2702986; rs35983466; rs4736427; rs35000085; rs34511753; rs34029436; rs35779760; rs7829320; rs28579253; rs2981294; rs34781226; rs28428818; rs10956685; rs2739055; rs11268816; rs11316187; rs36223872; rs35432641; rs28719581; rs28393420; rs12676508; rs7820791; rs34713535; rs13266643; rs34290542; rs35286448; rs3076090; rs28452373; rs34965607; rs2958695; rs34352106; rs36011474; rs7835552; rs34419422; rs909360; rs34115098; rs3892190; rs34527875; rs34207784; rs2958690; rs12548841; rs853312; rs7012120; rs34649941; rs35056813; rs853324; rs2979047; rs34300693; rs12541293; rs7016620; rs34401566; rs34528002; rs180209; rs35431905; rs10624943; rs10086291; rs2981293; rs2958689; rs853313; rs3832581; rs13439049; rs35340140; rs28402248; rs35292436; rs861203; rs853299; rs11395047; rs11335158; rs10639958; rs33985805; rs11778569; rs35975996; rs34975986; rs35140466; rs10092528; rs13260781; rs35977562; rs34409761; rs35755717; rs34906603; rs35729450; rs35149312; rs35275167; rs35676595; rs16904819; rs2294001; rs35215721; rs1811812; rs4736632; rs10660502; rs34542708; rs940077; rs36225951; rs2958682; rs36002632; rs13254863; rs33990330; rs7840281; rs2979024; rs35079765; rs6992619; rs11997110; rs16904826; rs28445135; rs12547060; rs2702980; rs28727293; rs2979031; rs2467990; rs34843766; rs34669143; rs6989555; rs16904820; rs7461513; rs28654406; rs35917695; rs10094088; rs36221525; rs33910057; rs34799712; rs34475728; rs34861244; rs35457246; rs2294004; rs34338140; rs7011227; rs33972433; rs34300442; rs5895167; rs28654846; rs34989595; rs13263197; rs4576410; rs35944432; rs3992994; rs10095026; rs35636762; rs35059390; rs34637329; rs28620579; rs12680667; rs34249106; rs10650506; rs34971750; rs2739056; rs28680551; rs28573183; rs34904146; rs10112059; rs16904831; rs35584041; rs35769648; rs7015805; rs28547062; rs34581780; rs34569436; rs10570581; rs16904834; rs28640053; rs28384408; rs11269191; rs34691975; rs11277781; rs35468381; rs10102363; rs36110471; rs11988144; rs16904787; rs35844025; rs2958696; rs35542042; rs7828465; rs35161639; rs2739052; rs34491481; rs11359047; rs28758516; rs11786128; rs28540916; rs2979043; rs34420477; rs4404893; rs34052396; rs10639957; rs35870007; rs180214; rs36055972; rs2958701; rs35565593; rs34432553; rs34839909; rs35644874; rs34047530; rs2739167; rs6994282; rs34473243; rs36059290; rs34840168; rs35683386; rs34949600; rs2958675; rs7012887; rs28582446; rs11272738; rs11779877; rs36056438; rs4330673; rs5895163; rs35515477; rs34393101; rs1882977; rs853325; rs34619069; rs5895174; rs180218; rs36223983; rs35376892; rs180203; rs33977608; rs35235993; rs34690484; rs34220859; rs35833882; rs7013696; rs3758109; rs35213262; rs13278046; rs34036189; rs34079651; rs12674632; rs35128090; rs35996460; rs2958691; rs853320; rs34258994; rs33942146; rs35196927; rs2702975; rs454222; rs28611783; rs180199; rs180200; rs180198; rs34146730; rs3834381; rs180197; rs180196; rs3758116; rs436505; rs34276475; rs34933516; rs35054972; rs1006197; rs10087449; rs10093650; rs10093995; rs10096073; rs10099615; rs10106075; rs10107766; rs1010873; rs1049528; rs1049529; rs1049535; rs10755938; rs10808603; rs10808604; rs10956690; rs10956691; rs10956692; rs1122414; rs1123672; rs1124527; rs11990500; rs11993576; rs12164182; rs12549029; rs1403494; rs1533910; rs16904757; rs16904758; rs16904759; rs16904760; rs16904807; rs16904808; rs16904810; rs16904814; rs17622362; rs17683567; rs17695552; rs1916271; rs1916272; rs1916273; rs2037541; rs2069556; rs2069569; rs2142377; rs2205450; rs2205451; rs2244060; rs2249272; rs2252553; rs2252681; rs2252696; rs2252706; rs2252805; rs2252807; rs2252813; rs2252917; rs2253035; rs2256366; rs2293208; rs2403912; rs2461800; rs2467992; rs2467993; rs2472546; rs2472547; rs2472548; rs2687836; rs2687837; rs2702966; rs2702967; rs2702968; rs2702970; rs2702971; rs2702972; rs2702996; rs2703000; rs2703012; rs2739136; rs2739138; rs2739153; rs2739181; rs2739182; rs2741192; rs2741194; rs2741195; rs2741197; rs2741199; rs2741200; rs2741202; rs2777; rs2896691; rs2958699; rs2979046; rs3739266; rs3739268; rs3758110; rs3779965; rs4370513; rs4430072; rs4458855; rs4486183; rs4489309; rs4489310; rs4492356; rs4736436; rs4736618; rs4736619; rs4736620; rs4736634; rs6471110; rs6983548; rs7017140; rs7817183; rs7819747; rs880073; rs880075; rs883685; rs940079; rs954591; rs9942754

# Macromolecular_Interacting_Partner_4_General_References:
3595599; 9186272; 3971976; 3681978; 2991855; 11124863; 10524569; 1639210; 2914619; 8269951; 7793989; 8615697; 8797845; 2760035; 10448091; 12387814; 8094490; 10199792

# Macromolecular_Interacting_Partner_4_References:
2818564; 67547; 9506870; 9827658

End of HMDB00021

Beginning of HMDB00022
# Accession_No:
HMDB00022

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 12:48:38

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
3-Methoxytyramine

# Description:
The O-methylated derivative of dopamine. Dopamine is methylated by catechol-O-methyltransferase (COMT) to make 3-Methoxytyramine.  This compound can be broken down to homovanillic acid by monoamine oxidase and aldehyde dehydrogenase.  Elevated concentrations of this compound are indicated for a variety of brain and carcinoid tumors as well as certain mental disorders. 

# Synonyms:
3-Methoxy-4-hydroxyphenylethyl amine; 3-Methoxytyramine; 3-O-methyldopamine; 4-(2-Aminoethyl)-2-methoxyphenol; 4-(2-amino-ethyl)-2-methoxy-phenol; 4-(2-aminoethyl)-2-methoxy-Phenol; 5-(2-aminoethyl)guaiacol

# Chemical_IUPAC_Name:
4-(2-aminoethyl)-2-methoxy-phenol

# Chemical_Formula:
C9H13NO2

# Chemical_Structure:
tbl_chemical:::HMDB00022_ZOOM.png:::119283134837150354

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00022_THUMB.png:::119283134639189868

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Heterocyclic Amines; Catecholamines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
phenol or hydroxyhetarene; alkyl aryl ether; primary amine; primary aliphatic amine (alkylamine); aromatic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
167.09464

# Molecular_Weight_Avg:
167.20502

# Smiles_String_isomeric:
COC1=C(O)C=CC(CCN)=C1

# Smiles_String_canonical:
COC1=C(O)C=CC(CCN)=C1

# KEGG_Compound_ID:
C05587

# BioCyc_ID:
Not Available

# PubChem_CID:
1669

# PubChem_SID:
3885186; 6385644; 10526958; 11111459; 3137085; 7912; 563328; 10324234; 8151227

# OMIM_ID:
Not Available

# Metagene_ID:
AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354; MONOAMINE OXIDASE-A DEFICIENCY (MAO-A): 446

# BiGG_ID:
46076

# Wikipedia_ID:
Not Available

# METLIN_ID:
5094

# Ref_ID:
2927387; 7004664; 262188; 6749220; 12138004; 4073504; 12649306; 15556832; 12105105; 7251775; 4281061; 872373; 3434205; 15542730; 15120096

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
554-52-9

# InChI:
InChI=1/C9H13NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4-5,10H2,1H3

# Synthesis_Reference:
 Journal of the American Chemical Society  (1950),  72  2781-2.

# Melting_Point:
Not Available

# Melting_Point_predicted:
95.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1000.0 mg/mL [MEYLAN,WM et al. (1996)]; 5.36 mg/mL [Predicted by ALOGPS]

# phys_charge:
1

# State:
Solid

# LogP:
-0.08 [SANGSTER (1994)]

# LogP_predicted:
-0.03 [Predicted by ALOGPS]; 0.8 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::3-Methoxytyramine hydrochloride.pdf:::1132562190264389390

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::3-Methoxytyramine.mol:::1132723801843603089

# SDF_File_[Text]:
tbl_chemical:::HMDB00022.sdf:::119283134255885631

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00022.pdb:::119283134471649943

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_presat_expanded_2.gif:::114168243533697090

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_presat.zip:::117512428532887921

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041029_P00_03_HW_1DP_Assigned.png:::114659163726823364

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619.png:::114781137104939439

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619.zip:::114781137107746152

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041029_P00_03_HW_2DHSQC_619_Assigned.png:::116180789755556652

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Methoxytyramine.gif:::1132732099343905484

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00022_peaks.txt:::1156309491433949289

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Methoxytyramine_C.gif:::1132737658338315089

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00022_peaks.txt:::1156310683314712352

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00022L.png:::117555261815580220; Medium Energy:tbl_ms:::HMDB00022M.png:::117555266932443287; High Energy:tbl_ms:::HMDB00022H.png:::117555270825292267

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Blood	0.00003	umol/L	Adult:>18_yrs_old	Both	Normal	12649306
Blood	0.0025 (0.0016-0.0029)	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Autism; Carcinoid Tumour; Neuroblastoma; Pheochromocytoma

# Pathway_Names:
Tyrosine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00350

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5393

# Metabolic_Enzyme_1_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_1_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_1_Gene_Name:
MAOB

# Metabolic_Enzyme_1_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_1_Number_of_Residues:
520

# Metabolic_Enzyme_1_Molecular_Weight:
58764

# Metabolic_Enzyme_1_Theoretical_pI:
7.55

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_1_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_1_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
MAOB

# Metabolic_Enzyme_1_Geneatlas_id:
MAOB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_1_PDB_ID:
2BK3

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_1_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp11.23

# Metabolic_Enzyme_1_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_1_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5401

# Metabolic_Enzyme_2_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_2_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_2_Gene_Name:
MAOA

# Metabolic_Enzyme_2_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_2_Number_of_Residues:
527

# Metabolic_Enzyme_2_Molecular_Weight:
59682

# Metabolic_Enzyme_2_Theoretical_pI:
7.96

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_2_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_2_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAOA

# Metabolic_Enzyme_2_Geneatlas_id:
MAOA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_2_PDB_ID:
1O5W

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_2_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_2_Locus:
Xp11.3

# Metabolic_Enzyme_2_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_2_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5504

# Metabolic_Enzyme_3_Name:
Catechol O-methyltransferase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
COMT

# Metabolic_Enzyme_3_Protein_Sequence:
>Catechol Omethyltransferase
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP

# Metabolic_Enzyme_3_Number_of_Residues:
271

# Metabolic_Enzyme_3_Molecular_Weight:
30037

# Metabolic_Enzyme_3_Theoretical_pI:
5.15

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  O-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_3_Reaction:
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01596:Methyltransf_3

# Metabolic_Enzyme_3_Signals:
1-32

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.1.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
180920

# Metabolic_Enzyme_3_SwissProt_ID:
COMT_HUMAN (P21964)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
COMT

# Metabolic_Enzyme_3_Geneatlas_id:
COMT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2228

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Isoform S-COMT:Cytoplasm. Isoform MB-COMT:Cell membrane; single-pass type II membrane protein; extracellular side

# Metabolic_Enzyme_3_Gene_Sequence:
>816 bp
ATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTG
GTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGCTGGAACGAG
TTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTG
AACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAGGCCATTGAC
ACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTG
GACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCCTACTGTGGC
TACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAG
ATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGCGTGAAGGAC
AAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTAT
GATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTACCTGCCGGAC
ACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAAC
GTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGCTGCTTTGAG
TGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCC
ATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M65212

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q11.21-q11.23|22q11.21

# Metabolic_Enzyme_3_SNPs:
rs5031015; rs6267; rs4680; rs13306279; rs13306281; rs6270; rs740602; rs8192488; rs4818; rs769223; rs769224; rs165631; rs4633; rs6269; rs739368; rs165656; rs4646312; rs5992501; rs7287550; rs165722; rs5746849; rs11569715; rs740603; rs9332380; rs7290221; rs174674; rs9332351; rs3810595; rs174675; rs5993887; rs9332361; rs6518593; rs174680; rs9332356; rs5993882; rs11569716; rs3087869; rs9332325; rs174673; rs174678; rs5993883; rs933271; rs9332359; rs165767; rs9332347; rs8185002; rs5993879; rs9332363; rs174691; rs9332332; rs5992500; rs174682; rs9332346; rs13306280; rs362204; rs174688; rs9332342; rs11569717; rs174695; rs5993881; rs7291003; rs1544325; rs9332331; rs3819621; rs174684; rs34798238; rs174677; rs174690; rs9606196; rs174693; rs11912353; rs12053782; rs11913025; rs36111598; rs5993888; rs9332362; rs174685; rs34438295; rs5992499; rs34691071; rs9332357; rs174692; rs9332334; rs3838146; rs9332333; rs9332352; rs35014456; rs35527466; rs35558779; rs11704299; rs9332350; rs6268; rs34450201; rs9680656; rs1055503; rs11912354; rs11089323; rs5993884; rs16982842; rs174679; rs9332353; rs34300220; rs9332358; rs9332360; rs34937293; rs34966851; rs174676; rs16982844; rs5844402; rs9332323; rs35919169; rs174683; rs35777291; rs9332348; rs8140865; rs34686565; rs165737; rs4646315; rs2239393; rs165774; rs9306235; rs740601; rs5993889; rs9306234; rs4646316; rs8140835; rs4646317; rs9332370; rs174697; rs174696; rs9332377; rs4646318; rs1109436; rs9332368; rs3218737; rs34068292; rs9332369; rs9332364; rs9332372; rs9332367; rs9332365; rs4646313; rs34446512; rs34819182; rs174699; rs34234839; rs165895; rs165599; rs9332381; rs35478083; rs36082074; rs11544670; rs4986871; rs11544669; rs165879; rs35791904; rs35788262; rs13054814; rs5992498; rs5748490; rs361698; rs28600912; rs9605040; rs11703339; rs9332319; rs174689; rs9606193; rs5844403; rs9332340; rs34778315; rs11703340; rs5993886; rs14968; rs9332344; rs28621910; rs3081743; rs174681; rs361549; rs35280052; rs361708; rs12167365; rs2004497; rs12170804; rs35357972; rs9332321; rs361574; rs9332328; rs35920235; rs9332337; rs5993880; rs12814; rs9332343; rs11544667; rs9606195; rs9332349; rs11296030; rs5748492; rs9332354; rs34029447; rs35188675; rs3819619; rs8136901; rs35094299; rs9332322; rs28804429; rs174687; rs9332339; rs11912495; rs35617967; rs9332327; rs9332336; rs3841769; rs12167215; rs362253; rs9332338; rs35689277; rs11703069; rs174686; rs12168881; rs9606194; rs361699; rs9332355; rs3081741; rs5746850; rs9617852; rs28565095; rs13306277; rs174698; rs9332373; rs9332374; rs9332366; rs13054356; rs35819339; rs11460758; rs4646314; rs34016976; rs2904564; rs12158230; rs13055002; rs9332375; rs28562050; rs9332378; rs9332371; rs9332376; rs10427781; rs10427983; rs10483103; rs1110477; rs1110478; rs1110479; rs12165997; rs12169508; rs12627876; rs165655; rs165728; rs165815; rs165824; rs165840; rs165849; rs1800749; rs2020917; rs2073749; rs2239394; rs2239395; rs2240713; rs2240714; rs2240715; rs2240718; rs2518823; rs2518824; rs2871047; rs34134422; rs35219372; rs3788319; rs3788320; rs4646310; rs5746846; rs5746847; rs5748483; rs5748484; rs5993890; rs5993891; rs7288060; rs737864; rs737865; rs737866; rs758373; rs8140265; rs887199; rs887200; rs9265; rs9332314; rs9332315; rs9605030; rs9605031; rs9606186; rs9606189; rs9606201; rs9618716

# Metabolic_Enzyme_3_General_References:
1707278; 1847521; 8055944; 1993083; 1765063; 8807664; 10391209

# Metabolic_Enzyme_3_References:
Not Available

End of HMDB00022

Beginning of HMDB00023
# Accession_No:
HMDB00023

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-17 12:35:56

# biospider_lastupdate:
2007-07-12 11:26:36

# Common_Name:
(S)-3-Hydroxyisobutyric acid

# Description:
(S)-3-Hydroxyisobutyric (3-HIBA) acid is an organic acid. 3-HIBA is an intermediate in the metabolic pathways of L-valine and L-thymine amino acids. 3-HIBA plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria (OMIM 236795) and methylmalonic semialdehyde dehydrogenase deficiency (OMIM 603178). Patients with 3-hydroxyisobutyric aciduria excrete a significant amount of 3-HIBA not only during the acute stage but also when stable. The deficient enzyme in 3HiB-uria remains unclear. The severity of this disease varies from case to case. Most patients exhibit dysmorphic features, such as a small triangular face, a long philtrum, low set ears and micrognathia (PMID: 113770040, 10686279)

# Synonyms:
(S)-3-Hydroxyisobutyric acid; 2-methyl-L-(+)-Hydracrylate; 2-methyl-L-(+)-Hydracrylic acid; 3-Hydroxy-2-methylpropanoate; 3-Hydroxy-2-methylpropanoic acid; 3-Hydroxyisobutyrate; 3-Hydroxyisobutyric acid; 3-hydroxy-2-methyl-(S)-Propanoate; 3-hydroxy-2-methyl-(S)-Propanoic acid; 3-hydroxy-isobutyrate

# Chemical_IUPAC_Name:
3-hydroxy-2-methyl-propanoic acid

# Chemical_Formula:
C4H8O3

# Chemical_Structure:
tbl_chemical:::HMDB00023_ZOOM.png:::119283135776224956

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00023_THUMB.png:::119283135587577041

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary alcohol; carboxylic acid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
104.04735

# Molecular_Weight_Avg:
104.10452

# Smiles_String_isomeric:
CC(CO)C(O)=O

# Smiles_String_canonical:
CC(CO)C(O)=O

# KEGG_Compound_ID:
C01188

# BioCyc_ID:
3-HYDROXY-ISOBUTYRATE

# PubChem_CID:
87

# PubChem_SID:
1995; 6820032; 8143904; 8150449; 4414; 766462

# OMIM_ID:
236795; 250620

# Metagene_ID:
3-HYDROXYISOBUTYRIC ACIDURIA: 307; KETOSIS, UNSPECIFIC [DD]: 279; METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY: 485

# BiGG_ID:
37034

# Wikipedia_ID:
Not Available

# METLIN_ID:
483

# Ref_ID:
2104971; 2732286; 10686279; 1625099; 126826; 8412012

# ChEBI_ID:
18064

# CAS_Registry_Number:
2068-83-9

# InChI:
InChI=1/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)

# Synthesis_Reference:
D(-)-b-Hydroxyisobutyric acid by fermentation.     Robison, Robert S.; Szarka, Laszlo J.  (E. R. Squibb and Sons, Inc., USA).    Eur. Pat. Appl.  (1985),     19 pp.

# Melting_Point:
Not Available

# Melting_Point_predicted:
25.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
571.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.7 [Predicted by PubChem via XLOGP]; -0.47 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00023.mol:::118426119867771865

# SDF_File_[Text]:
tbl_chemical:::HMDB00023.sdf:::119283135260874438

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00023.pdb:::119283135424980194

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::HMDB00023.zip:::118428001166367156

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_S02_38_BA_Assigned.png:::118428001171645855

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Hydroxyisobutyric acid.gif:::113273209956223339

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00023_peaks.txt:::115630949244340696

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Hydroxyisobutyric acid_C.gif:::1132737659029445305

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00023_peaks.txt:::1156310684338511979

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00023.png:::1165434255636916906; Medium Energy:tbl_ms:::HMDB00023.png:::1165434125921946969; High Energy:tbl_ms:::HMDB00023.png:::1165434169814186494

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; mitochondria

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	20.0 (4.0-48.0)	umol/L	Adult:>18_yrs_old	Both	Normal	8412012
Cerebrospinal_Fluid(CSF)	18.0 +/- 18.0 (0 - 36)	uM	Adult:>18_yrs_old	N/A	Normal	8412012


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
3-Hydroxyisobutyric Aciduria

# Pathway_Names:
Valine, leucine and isoleucine degradation;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
valine,leucine,and_isoleucine_degradation.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00280;map00280;map00280

# Pathway_Graphs:
valine,leucine,and_isoleucine_degradation_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
valine,leucine,and_isoleucine_degradation.xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5632

# Metabolic_Enzyme_1_Name:
3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
HIBADH

# Metabolic_Enzyme_1_Gene_Name:
HIBADH

# Metabolic_Enzyme_1_Protein_Sequence:
>3hydroxyisobutyrate dehydrogenase, mitochondrial precursor
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK
HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL
KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED
EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL
AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF

# Metabolic_Enzyme_1_Number_of_Residues:
336

# Metabolic_Enzyme_1_Molecular_Weight:
35329

# Metabolic_Enzyme_1_Theoretical_pI:
8.26

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  phosphogluconate dehydrogenase (decarboxylating) activity
Function:  phosphogluconate dehydrogenase (decarboxylating) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  3-hydroxyisobutyrate dehydrogenase activity
 ||
>>>
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  pentose-phosphate shunt
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  branched chain family amino acid metabolism
Process:  valine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
3-hydroxy-2-methylpropanoate + NAD(+) = 2- methyl-3-oxopropanoate + NADH

# Metabolic_Enzyme_1_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_1_Reaction:
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03446:NAD_binding_2

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.31

# Metabolic_Enzyme_1_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_1_SwissProt_ID:
3HIDH_HUMAN (P31937)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
HIBADH

# Metabolic_Enzyme_1_Geneatlas_id:
HIBADH

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4907

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
Not Available

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AC007130

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7p15.2

# Metabolic_Enzyme_1_SNPs:
rs11550134; rs3735571; rs1052741; rs1052724; rs2391443; rs2160125; rs961725; rs1980330; rs978447; rs1014373; rs2391453; rs1009252; rs723699; rs974883; rs2391447; rs1980329; rs1404282; rs1524532; rs1851913; rs42088; rs42085; rs7806812; rs961724; rs1524529; rs4719902; rs7806415; rs1014372; rs6945993; rs6958747; rs1030003; rs7783447; rs1357760; rs12155430; rs7789788; rs12670250; rs7779990; rs6970104; rs12667235; rs10951175; rs6961867; rs10486548; rs6462037; rs1524527; rs6415252; rs1554641; rs2391446; rs10951176; rs4348389; rs4140899; rs6462034; rs1524530; rs4722727; rs1880370; rs10951172; rs42087; rs6974387; rs6462038; rs2192559; rs6974932; rs1524533; rs12700830; rs13244903; rs999491; rs12700817; rs4722726; rs759270; rs6964190; rs4722719; rs2893292; rs12667610; rs9639552; rs759268; rs6462039; rs7808275; rs6415251; rs961723; rs12540276; rs1404276; rs6960834; rs2080245; rs11979446; rs6947004; rs6946075; rs6947731; rs6462033; rs11762056; rs1015750; rs1608664; rs11761718; rs17607303; rs2041714; rs12665991; rs12700829; rs12539472; rs6963421; rs13227873; rs6462029; rs4719901; rs11772163; rs12667470; rs10486553; rs12537499; rs6980382; rs723700; rs7778320; rs4722728; rs759272; rs2110524; rs11761773; rs12670415; rs12674175; rs10486550; rs12671723; rs1115346; rs12535844; rs1229605; rs12700825; rs10447552; rs6957378; rs7455882; rs11982323; rs6946305; rs6462031; rs10486549; rs2391451; rs12164139; rs759269; rs13242248; rs6955074; rs1009253; rs3735570; rs16874305; rs17155443; rs2391445; rs7786973; rs42086; rs1000317; rs2098315; rs6948814; rs1851911; rs11764624; rs1608663; rs6943883; rs6959495; rs2391444; rs7809748; rs1404278; rs2391452; rs7788376; rs11764753; rs12530626; rs11764419; rs6963585; rs12668430; rs10486547; rs986706; rs2110526; rs6954905; rs4722724; rs1015265; rs10951174; rs17155450; rs12111584; rs13236908; rs17680908; rs12670771; rs6944610; rs11973492; rs4722720; rs7796520; rs7794292; rs6462036; rs16874328; rs17155494; rs12700824; rs16874321; rs2110527; rs17682155; rs17155546; rs1005128; rs10081338; rs1115347; rs13227574; rs11972463; rs4722717; rs6958467; rs17155460; rs7778454; rs1524531; rs12700826; rs10807841; rs3925338; rs1524526; rs962925; rs4722725; rs11767188; rs6959865; rs2391450; rs12112192; rs12700823; rs6976178; rs10233212; rs17155501; rs12672811; rs2110528; rs4719899; rs10266854; rs17155498; rs2391442; rs7806605; rs12700815; rs7780431; rs7790498; rs769368; rs10951171; rs6966587; rs2041715; rs4722718; rs12531518; rs1986243; rs17155505; rs17155537; rs2037638; rs1229604; rs1851912; rs12700819; rs11762342; rs7795207; rs12540063; rs13241127; rs17155465; rs12534603; rs9639553; rs759271; rs10256159; rs13227521; rs13232561; rs12700813; rs6651068; rs12673949; rs6944025; rs16874319; rs17607155; rs17683094; rs2391439; rs12700828; rs6959126; rs11773033; rs2098316; rs13246464; rs2391454; rs4719903; rs16874325; rs1986215; rs7805086; rs6975900; rs12672823; rs6462032; rs1880371; rs13231645; rs11526176; rs17155513; rs11971346; rs2391449; rs2391438; rs10951173; rs6948460; rs2080246; rs9639560; rs9639559; rs12700821; rs12113735; rs17155566; rs7811436; rs10486552; rs17607608; rs17155525; rs7456595; rs12531952; rs42089; rs4719898; rs3847001; rs6956484; rs6961429; rs13242238; rs6969043; rs6462027; rs11971886; rs4719897; rs6968631; rs6969207; rs35454595; rs35946970; rs11408852; rs5009225; rs6962817; rs13307738; rs3905446; rs5883095; rs12531947; rs34071982; rs35779560; rs11343650; rs35467427; rs1123445; rs17155541; rs3922286; rs34698857; rs34125931; rs13228040; rs35461964; rs35124908; rs3072888; rs12674403; rs33933634; rs2391437; rs33983898; rs13229467; rs12113593; rs35272178; rs34536886; rs35083158; rs34764301; rs36091381; rs34019098; rs9639551; rs35733358; rs17609417; rs35213965; rs35969430; rs3072850; rs10591084; rs34920159; rs34504304; rs35121197; rs12055920; rs10244508; rs34950198; rs34206933; rs5883091; rs41326151; rs11274075; rs6975597; rs10637650; rs35359839; rs3072898; rs34491908; rs13234803; rs34640888; rs35477948; rs11289715; rs10628041; rs13240752; rs34453577; rs1229606; rs5883094; rs7777523; rs11763449; rs6955472; rs34329289; rs35840171; rs35662263; rs3072901; rs34708981; rs1404277; rs35465476; rs35115558; rs35881985; rs34906269; rs28461898; rs35925990; rs5883089; rs6150044; rs11520704; rs34360572; rs1030002; rs7807597; rs34065248; rs4495321; rs10544725; rs11344706; rs4000635; rs35429121; rs11442513; rs34275714; rs13228144; rs13240957; rs35733141; rs28547285; rs13228800; rs35347183; rs10280216; rs35651615; rs3072889; rs7456657; rs35970473; rs6944455; rs1554640; rs2391448; rs5883090; rs35937817; rs12155431; rs4719900; rs13307528; rs35870816; rs36140938; rs34311576; rs35711061; rs34173110; rs35114679; rs11269935; rs35977021; rs35562626; rs3072856; rs11355038; rs28429439; rs6980386; rs34169544; rs17610547; rs35642553; rs5883087; rs34886410; rs7456656; rs10240428; rs35804923; rs11274711; rs7459009; rs11386502; rs13242241; rs13310486; rs35283108; rs34357333; rs10642707; rs35473122; rs34459017; rs2391441; rs5883097; rs13226102; rs13247662; rs34923508; rs3072887; rs5883100; rs33968860; rs35850169; rs6966091; rs1030001; rs28539571; rs13229579; rs3072924; rs7457947; rs34415273; rs13310749; rs34400365; rs35816118; rs12700822; rs34236612; rs34036272; rs2391440; rs35344159; rs34707991; rs34748212; rs35402898; rs34552407; rs35249568; rs13310466; rs2110525; rs11434769; rs5883088; rs35812055; rs10569030; rs35240005; rs36095835; rs1851909; rs12539707; rs6150043; rs1005418; rs34038351; rs5883093; rs35635917; rs35672101; rs28416309; rs6956238; rs11402963; rs34638402; rs1235364; rs28433694; rs35475209; rs35820093; rs34444109; rs10264586; rs5883096; rs34784239; rs7803464; rs5883099; rs34906094; rs1524525; rs7782422; rs10629006; rs35908911; rs6950698; rs35149329; rs17607043; rs10586738; rs35724262; rs12700814; rs36069602; rs35771883; rs34905189; rs11356347; rs11317913; rs3072931; rs34064591; rs34450880; rs4478473; rs35131335; rs10081339; rs11460373; rs34062015; rs13228142; rs35572534; rs3915090; rs34437775; rs7777507; rs34453559; rs1229607; rs34081161; rs34847398; rs10553105; rs6150042; rs11411482; rs13308974; rs5883092; rs12155440; rs28503587; rs34051183; rs6946582; rs35442974; rs34578407; rs10248276; rs35914219; rs11765792; rs34735996; rs34807722; rs10272298; rs11305053; rs12700831; rs35105727; rs28372805; rs35871970; rs10951169; rs1111647; rs11768533; rs11771265; rs12112727; rs12234338; rs12534474; rs12534656; rs13237776; rs13245339; rs16874296; rs2091170; rs2091171; rs4355682; rs6462022; rs6462023; rs6945079; rs6949496; rs6956464; rs6957674; rs6966918; rs6972650; rs6974052; rs7779240; rs7789363; rs940525; rs940526

# Metabolic_Enzyme_1_General_References:
12853948; 8313870

# Metabolic_Enzyme_1_References:
Not Available

End of HMDB00023

Beginning of HMDB00024
# Accession_No:
HMDB00024

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-12 10:29:40

# biospider_lastupdate:
2007-09-12 10:34:03

# Common_Name:
3-O-Sulfogalactosylceramide

# Description:
An acidic, sulfated glycosphingolipid, often known as sulfatide.  This lipid occurs in membranes of various cell types, but is found in particularly high concentrations in myelin where it constitutes 3-4% of total membrane lipids.  This lipid is synthesized primarily in the oligodendrocytes in the central nervous system.  Accumulation of this lipid in the lysosomes is a characteristic of metachromatic leukodystrophy, a lysosomal storage disease caused by the deficiency of arylsulfatase A.  Alterations in sulfatide metabolism, trafficking, and homeostasis are present in the earliest clinically recognizable stages of Alzheimer's disease.

# Synonyms:
3'-O-Sulphogalactosylceramide; 3-O-Sulfogalactosylceramide; 3-O-Sulphogalactosylceramide; 3-O-sulfo-beta-D-galactosylceramide; Cerebroside 3-sulfate; Galactosylceramide-sulfate; Galactosylceramidesulfate; Sulfatide; 3-O-sulfo-beta-delta-galactosylceramide

# Chemical_IUPAC_Name:
[(2R,3S,4S,5R,6R)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2S,3R)-3-hydroxy-2-(tetracosanoylamino)octadec-4-enoxy]oxan-4-yl] hydrogen sulfate

# Chemical_Formula:
C48H93NO11S

# Chemical_Structure:
tbl_chemical:::HMDB00024_ZOOM.png:::119283137202581902

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00024_THUMB.png:::119283136982744442

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Lipids; Fatty Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
alkene; secondary alcohol; heterocyclic compound; sulfuric acid monoester; primary alcohol; acetal; secondary carboxylic acid amide

# Taxonomy_Biofunction:
Component of Glycosphingolipid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
891.64685

# Molecular_Weight_Avg:
892.31714

# Smiles_String_isomeric:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OS(O)(=O)=O)[C@H]1O)[C@H](O)C=CCCCCCCCCCCCCC

# Smiles_String_canonical:
CCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1OC(CO)C(O)C(OS(O)(=O)=O)C1O)C(O)C=CCCCCCCCCCCCCC

# KEGG_Compound_ID:
C06125

# BioCyc_ID:
GALACTOSYLCERAMIDE-SULFATE

# PubChem_CID:
6451121

# PubChem_SID:
10559604; 639428; 8382

# OMIM_ID:
249900; 256540; 272750

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Sulfatide

# METLIN_ID:
5096

# Ref_ID:
2764035; 1808356; 8455580; 1543730; 10518409; 8080249; 8595716; 6146271; 1970953; 14528918; 15627618; 6119972; 6415115; 6881139; 15772092

# ChEBI_ID:
Not Available

# CAS_Registry_Number:
3688-74-2

# InChI:
InChI=1/C48H93NO11S/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48/h35,37,41-43,45-48,50-51,53-54H,3-34,36,38-40H2,1-2H3,(H,49,52)(H,55,56,57)/b37-35+/t41-,42+,43+,45-,46+,47-,48+/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
2.09e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
6.01 [Predicted by ALOGPS]; 12.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00024.mol:::118918508780258965

# SDF_File_[Text]:
tbl_chemical:::HMDB00024.sdf:::119283136221069911

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00024.pdb:::119283136804238429

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-O-Sulfogalactosylceramide.gif:::1132732099796898484

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00024_peaks.txt:::1156309493497573058

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-O-Sulfogalactosylceramide_C.gif:::1132737659710455661

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00024_peaks.txt:::1156310685346651710

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Lysosome; membrane

# Tissue_Location:
Brain; Kidney; Myelin

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.205 (0.07-0.34)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	8595716


# Concentration_[Abnormal]:
Urine	12.7 (1.2-24.2)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Metachromatic Leukodystrophy (MLD)	8595716


# Associated_Disorders:
Metachromatic Leukodystrophy (MLD)

# Pathway_Names:
Glycosphingolipid metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00600

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5560

# Metabolic_Enzyme_1_Name:
Arylsulfatase E precursor

# Metabolic_Enzyme_1_Synonyms:
ASE

# Metabolic_Enzyme_1_Gene_Name:
ARSE

# Metabolic_Enzyme_1_Protein_Sequence:
>Arylsulfatase E precursor
MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNT
MRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASG
GLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGD
CARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLAS
SYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHV
HIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLEN
QLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVR
LAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFV
TPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMER
VQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ

# Metabolic_Enzyme_1_Number_of_Residues:
589

# Metabolic_Enzyme_1_Molecular_Weight:
65670

# Metabolic_Enzyme_1_Theoretical_pI:
6.96

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_1_Signals:
1-31

# Metabolic_Enzyme_1_Transmembrane_Regions:
200-222; 227-249; 289-311

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_1_GenBank_ID_Protein:
791004

# Metabolic_Enzyme_1_SwissProt_ID:
ARSE_HUMAN (P51690)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ARSE

# Metabolic_Enzyme_1_Geneatlas_id:
ARSE

# Metabolic_Enzyme_1_hgnc_id:
HGNC:719

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Golgi apparatus; Golgi stack

# Metabolic_Enzyme_1_Gene_Sequence:
>1770 bp
ATGTTACATCTGCACCATTCTTGTTTGTGTTTCAGGAGCTGGCTGCCAGCGATGCTCGCT
GTACTGCTAAGTTTGGCACCATCAGCTTCCAGCGACATTTCCGCCTCCCGACCGAACATC
CTTCTTCTGATGGCGGACGACCTTGGCATTGGGGACATTGGCTGCTATGGCAACAACACC
ATGAGGACTCCGAATATTGACCGCCTTGCAGAGGACGGCGTGAAGCTGACCCAACACATC
TCTGCCGCATCTTTGTGCACCCCAAGCAGAGCCGCCTTCCTCACGGGCAGATACCCTGTG
CGATCAGGGATGGTTTCCAGCATTGGTTACCGTGTTCTTCAGTGGACCGGAGCATCTGGA
GGTCTTCCAACAAATGAGACAACTTTTGCAAAAATACTGAAAGAGAAAGGCTATGCCACT
GGACTCATTGGAAAATGGCATCTGGGTCTCAACTGTGAGTCAGCCAGTGATCATTGCCAC
CACCCTCTCCATCATGGCTTTGAGCATTTCTACGGAATGCCTTTCTCCTTGATGGGTGAT
TGCGCCCGCTGGGAACTCTCAGAGAAGCGTGTCAACCTGGAACAAAAACTCAACTTCCTC
TTCCAAGTCCTGGCCTTGGTTGCCCTCACACTGGTAGCAGGGAAGCTCACACACCTGATA
CCCGTCTCGTGGATGCCGGTCATCTGGTCAGCCCTTTCGGCCGTCCTCCTCCTCGCAAGC
TCCTATTTTGTGGGTGCTCTGATTGTCCATGCCGATTGCTTTCTGATGAGAAACCACACC
ATCACGGAGCAGCCCATGTGCTTCCAAAGAACGACACCCCTTATTCTGCAGGAGGTTGCG
TCCTTTCTCAAAAGGAATAAGCATGGGCCTTTCCTCCTCTTTGTTTCCTTTCTACACGTT
CACATCCCTCTTATCACTATGGAGAACTTCCTCGGGAAGAGTCTCCACGGGCTGTATGGG
GACAACGTAGAGGAGATGGACTGGATGGTAGGACGGATCCTTGACACTTTGGACGTGGAG
GGTTTGAGCAACAGCACCCTCATTTATTTTACGTCGGATCACGGCGGTTCCCTAGAGAAT
CAACTTGGAAACACCCAGTATGGTGGCTGGAATGGAATTTATAAAGGTGGGAAGGGCATG
GGAGGATGGGAAGGTGGGATCCGCGTGCCCGGGATCTTCCGCTGGCCCGGGGTGCTCCCG
GCCGGCCGAGTGATTGGCGAGCCCACGAGTCTGATGGACGTGTTCCCCACCGTGGTCCGG
CTGGCGGGCGGCGAGGTGCCCCAGGACAGAGTGATTGACGGCCAAGACCTTCTGCCCTTG
CTCCTGGGGACAGCCCAACACTCAGACCACGAGTTCCTGATGCATTATTGTGAGAGGTTT
CTGCACGCAGCCAGGTGGCATCAACGGGACAGAGGAACAATGTGGAAAGTCCACTTTGTG
ACGCCTGTGTTCCAGCCAGAGGGAGCCGGTGCCTGCTATGGAAGAAAGGTCTGCCCGTGC
TTTGGGGAAAAAGTAGTCCACCACGATCCACCTTTGCTCTTTGACCTCTCAAGAGACCCT
TCTGAGACCCACATCCTCACACCAGCCTCAGAGCCCGTGTTCTATCAGGTGATGGAACGA
GTCCAGCAGGCGGTGTGGGAACACCAGCGGACACTCAGCCCAGTTCCTCTGCAGCTGGAC
AGGCTGGGCAACATCTGGAGACCGTGGCTGCAGCCCTGCTGTGGCCCGTTCCCCCTCTGC
TGGTGCCTTAGGGAAGATGACCCACAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X83573

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xp22.3

# Metabolic_Enzyme_1_SNPs:
rs34412194; rs35143646; rs11222; rs17325750; rs11055; rs35718384; rs1875647; rs176994; rs12687057; rs211644; rs211640; rs190023; rs211646; rs211639; rs11798027; rs1972528; rs1985082; rs2302079; rs4892825; rs211641; rs6641673; rs4892828; rs211636; rs4892827; rs11797823; rs12847525; rs211642; rs169828; rs4892826; rs211638; rs211645; rs5982928; rs4892910; rs12392879; rs12690163; rs4892909; rs211637; rs5982944; rs5982926; rs5982947; rs5982948; rs41310272; rs28935474; rs5982618; rs41308353; rs2302078; rs35274634; rs34795651; rs11386125; rs35172906; rs5982943; rs35727588; rs5982621; rs35930766; rs5982942; rs5982620; rs5982619; rs5982941; rs12862274; rs34368774; rs12014203; rs5982937; rs12842633; rs35373572; rs1985083; rs35557443; rs12841888; rs7055850; rs12852998; rs6642073; rs34095951; rs28695378; rs11439303; rs6641671; rs7877827; rs191925; rs12845799; rs5982940; rs6642075; rs5982929; rs5982933; rs12841639; rs12690083; rs5982930; rs2238847; rs6642074; rs5982932; rs12853008; rs12847404; rs211643; rs12836850; rs12853316; rs36060128; rs35703084; rs5982939; rs7881434; rs12841616; rs35328022; rs3216370; rs6642076; rs12853583; rs35961426; rs12394933; rs3753140; rs28520254; rs5982938; rs12842105; rs5982931; rs1972527; rs12847425; rs3753141; rs12845808; rs183318; rs12852742; rs34854714; rs35592318; rs12388707; rs41309659; rs28602557; rs6642071; rs28678263; rs5982945; rs28545096; rs34081519; rs5982946; rs5982927; rs11152554; rs12393627; rs12852717; rs2302077; rs3747393; rs3747394; rs3747395; rs3747396; rs3827454; rs5982955

# Metabolic_Enzyme_1_General_References:
7720070; 9497243; 9409863

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5557

# Metabolic_Enzyme_2_Name:
Arylsulfatase B precursor

# Metabolic_Enzyme_2_Synonyms:
ASB; N-acetylgalactosamine- 4-sulfatase; G4S

# Metabolic_Enzyme_2_Gene_Name:
ARSB

# Metabolic_Enzyme_2_Protein_Sequence:
>Arylsulfatase B precursor
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM

# Metabolic_Enzyme_2_Number_of_Residues:
533

# Metabolic_Enzyme_2_Molecular_Weight:
59688

# Metabolic_Enzyme_2_Theoretical_pI:
8.31

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Hydrolysis of the 4-sulfate groups of the N- acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_2_Pathway:
map00531  Glycosaminoglycan degradation

# Metabolic_Enzyme_2_Reaction:
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_2_Signals:
1-36

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.6.12

# Metabolic_Enzyme_2_GenBank_ID_Protein:
179077

# Metabolic_Enzyme_2_SwissProt_ID:
ARSB_HUMAN (P15848)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ARSB

# Metabolic_Enzyme_2_Geneatlas_id:
ARSB

# Metabolic_Enzyme_2_hgnc_id:
HGNC:714

# Metabolic_Enzyme_2_PDB_ID:
1FSU

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_2_Gene_Sequence:
>1602 bp
ATGGGTCCGCGCGGCGCGGCGAGCTTGCCCCGAGGCCCCGGACCTCGGCGGCTGCTCCTC
CCCGTCGTCCTCCCGCTGCTGCTGCTGCTGTTGTTGGCGCCGCCGGGCTCGGGCGCCGGG
GCCAGCCGGCCGCCCCACCTGGTCTTCTTGCTGGCAGACGACCTAGGCTGGAACGACGTC
GGCTTCCACGGCTCCCGCATCCGCACGCCGCACCTGGACGCGCTGGCGGCCGGCGGGGTG
CTCCTGGACAACTACTACACGCAGCCGCTGTGCACGCCGTCGCGGAGCCAGCTGCTCACT
GGCCGCTACCAGATCCGTACAGGTTTACAGCACCAAATAATCTGGCCCTGTCAGCCCAGC
TGTGTTCCTCTGGATGAAAAACTCCTGCCCCAGCTCCTAAAAGAAGCAGGTTATACTACC
CATATGGTCGGAAAATGGCACCTGGGAATGTACCGGAAAGAATGCCTTCCAACCCGCCGA
GGATTTGATACCTACTTTGGATATCTCCTGGGTAGTGAAGATTATTATTCCCATGAACGC
TGTACATTAATTGACGCTCTGAATGTCACACGATGTGCTCTTGATTTTCGAGATGGCGAA
GAAGTTGCAACAGGATATAAAAATATGTATTCAACAAACATATTCACCAAAAGGGCTATA
GCCCTCATAACTAACCATCCACCAGAGAAGCCTCTGTTTCTCTACCTTGCTCTCCAGTCT
GTGCATGAGCCCCTTCAGGTCCCTGAGGAATACTTGAAGCCATATGACTTTATCCAAGAC
AAGAACAGGCATCACTATGCAGGAATGGTGTCCCTTATGGATGAAGCAGTAGGAAATGTC
ACTGCAGCTTTAAAAAGCAGTGGGCTCTGGAACAACACGGTGTTCATCTTTTCTACAGAT
AACGGAGGGCAGACTTTGGCAGGGGGTAATAACTGGCCCCTTCGAGGAAGAAAATGGAGC
CTGTGGGAAGGAGGCGTCCGAGGGGTGGGCTTTGTGGCAAGCCCCTTGCTGAAGCAGAAG
GGCGTGAAGAACCGGGAGCTCATCCACATCTCTGACTGGCTGCCAACACTCGTGAAGCTG
GCCAGGGGACACACCAATGGCACAAAGCCTCTGGATGGCTTCGACGTGTGGAAAACCATC
AGTGAAGGAAGCCCATCCCCCAGAATTGAGCTGCTGCATAATATTGACCCAAACTTCGTG
GACTCTTCACCGTGTCCCAGGAACAGCATGGCTCCAGCAAAGGATGACTCTTCTCTTCCA
GAATATTCAGCCTTTAACACATCTGTCCATGCTGCAATTAGACATGGAAATTGGAAACTC
CTCACGGGCTACCCAGGCTGTGGTTACTGGTTCCCTCCACCGTCTCAATACAATGTTTCT
GAGATACCCTCATCAGACCCACCAACCAAGACCCTCTGGCTCTTTGATATTGATCGGGAC
CCTGAAGAAAGACATGACCTGTCCAGAGAATATCCTCACATCGTCACAAAGCTCCTGTCC
CGCCTACAGTTCTACCATAAACACTCAGTCCCCGTGTACTTCCCTGCACAGGACCCCCGC
TGTGATCCCAAGGCCACTGGGGTGTGGGGCCCTTGGATGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J05225

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5p11-q13|5q11-q13

# Metabolic_Enzyme_2_SNPs:
rs17220759; rs25414; rs1065757; rs25413; rs35757003; rs16876029; rs7704939; rs754567; rs754566; rs3088247; rs11750774; rs2173012; rs163127; rs163126; rs3098701; rs337865; rs234687; rs97729; rs337827; rs378912; rs337887; rs163215; rs339027; rs163299; rs337883; rs337826; rs338465; rs449839; rs7737068; rs378944; rs337879; rs3098678; rs3797550; rs2052550; rs337895; rs2925727; rs10039384; rs11960862; rs337852; rs3857405; rs337847; rs10474569; rs6453415; rs4704531; rs3098683; rs421734; rs10078690; rs9293758; rs7702409; rs6870550; rs337888; rs3846677; rs6453421; rs337851; rs7731315; rs337845; rs234910; rs3098679; rs4703768; rs12522844; rs337884; rs6874580; rs12658000; rs6887109; rs672413; rs4704535; rs6897944; rs7708387; rs337836; rs6863277; rs337885; rs10462560; rs3114495; rs7732099; rs11740104; rs186818; rs337846; rs4704534; rs337867; rs6453423; rs163216; rs4704530; rs7713155; rs751508; rs11743362; rs6887407; rs338460; rs6871810; rs921945; rs7717470; rs918580; rs4704525; rs447998; rs376749; rs10474567; rs337849; rs339032; rs337843; rs3114494; rs4704533; rs426586; rs784586; rs3852190; rs168091; rs10053925; rs1402684; rs180047; rs337853; rs6453420; rs10805924; rs7722869; rs7727110; rs4421085; rs7721866; rs7736777; rs10052939; rs3114493; rs10452492; rs559088; rs11747224; rs337844; rs3114492; rs6859069; rs12655291; rs16876147; rs3098695; rs3846679; rs16876062; rs7709486; rs10942879; rs97728; rs337835; rs336520; rs17219410; rs337875; rs6865582; rs16876106; rs3869024; rs163214; rs163128; rs2020404; rs6890245; rs6871197; rs414063; rs16875951; rs16875919; rs180295; rs3098681; rs6870443; rs6891547; rs10942870; rs180049; rs339030; rs3869025; rs32962; rs12054837; rs7710725; rs338458; rs6895479; rs189269; rs11739303; rs430185; rs10058204; rs3857404; rs6453417; rs337832; rs10942880; rs11748603; rs11957735; rs3098698; rs12655738; rs4704542; rs6861970; rs4704532; rs337841; rs4521454; rs3910652; rs413209; rs6876288; rs11738153; rs339034; rs11953253; rs337863; rs730836; rs7712469; rs6893857; rs11740161; rs12186484; rs3797556; rs6896300; rs337862; rs337833; rs10454896; rs338457; rs16875913; rs6890675; rs337877; rs784587; rs3114500; rs10045962; rs10805923; rs653413; rs12109559; rs17220863; rs3869026; rs7704725; rs16875940; rs10058261; rs337859; rs10514108; rs10942881; rs163129; rs3797552; rs337864; rs10514114; rs11740160; rs6888024; rs16875961; rs10044989; rs2919650; rs516908; rs7701898; rs10454897; rs16876110; rs337829; rs6895995; rs3869022; rs7706434; rs7725928; rs337850; rs2052549; rs3822473; rs11742709; rs12186766; rs3797554; rs427501; rs12654847; rs7711802; rs17818103; rs11741352; rs337876; rs6894968; rs17221983; rs7719520; rs12153089; rs339036; rs234688; rs9687996; rs10942868; rs4704524; rs3098680; rs6883131; rs12659281; rs339029; rs6898549; rs485142; rs337857; rs10462562; rs7730428; rs337834; rs10040033; rs339031; rs2043985; rs7724023; rs193123; rs16876057; rs3906812; rs17819357; rs10454895; rs427984; rs13340404; rs6897347; rs9632425; rs17820610; rs10064655; rs11955485; rs6453419; rs6860821; rs3098686; rs10039336; rs337840; rs12187930; rs12656514; rs11746751; rs11742408; rs784589; rs16876111; rs10042060; rs7705217; rs337828; rs671947; rs11748914; rs4447961; rs4470743; rs6453416; rs16876146; rs337881; rs339035; rs17221292; rs3098700; rs4703764; rs10805921; rs4704537; rs3098699; rs3822575; rs10055350; rs16876043; rs6870085; rs337856; rs337891; rs2919651; rs10039309; rs337860; rs9885048; rs191416; rs1866841; rs10942867; rs13184327; rs337886; rs16875905; rs16876115; rs11743827; rs12109126; rs7731288; rs336521; rs7729335; rs10755301; rs337878; rs184614; rs163130; rs784581; rs595479; rs7731568; rs17819944; rs9763635; rs13179571; rs4704528; rs10040776; rs3114501; rs337866; rs4704526; rs918581; rs10942872; rs650304; rs182880; rs11741182; rs17819603; rs688180; rs10040460; rs12658420; rs1866842; rs11749494; rs3822576; rs10462563; rs572281; rs784585; rs16875944; rs16876155; rs484234; rs16876279; rs11956583; rs16876048; rs180296; rs12654412; rs16875947; rs6887828; rs1583875; rs6897315; rs2919649; rs2099786; rs4704541; rs7731086; rs12109527; rs17218427; rs13185621; rs13177084; rs594686; rs784584; rs10462564; rs35676576; rs1899248; rs11739567; rs3098697; rs12515765; rs4515284; rs16876047; rs380061; rs16876045; rs12522377; rs6869313; rs9686232; rs3733895; rs3098684; rs11742860; rs12108732; rs3098692; rs17817904; rs3822577; rs10805922; rs337842; rs17818235; rs10942882; rs336523; rs13172853; rs13152961; rs2043984; rs16876063; rs339033; rs11740887; rs9765665; rs381184; rs337858; rs12656053; rs338462; rs7713152; rs10942877; rs12108960; rs11746011; rs337893; rs7730261; rs12109507; rs16875952; rs11744095; rs11739786; rs6887812; rs12187361; rs11957876; rs12515760; rs12108766; rs10040315; rs10942869; rs17819273; rs339028; rs6896262; rs16876044; rs11956904; rs3114497; rs12519566; rs9763091; rs11746616; rs7705475; rs12519881; rs16876150; rs337882; rs10072794; rs12188734; rs3822574; rs337830; rs16875946; rs11958663; rs16875902; rs13172903; rs337890; rs16875918; rs13184587; rs3951714; rs10040592; rs3114498; rs12522878; rs921944; rs10942878; rs7705181; rs16875949; rs17819429; rs337892; rs3098682; rs13178105; rs25415; rs12187584; rs7714654; rs9763629; rs12188045; rs10474568; rs12522380; rs12658374; rs7732938; rs163125; rs163124; rs16875887; rs10035905; rs7701438; rs7705926; rs1610960; rs34555226; rs613384; rs35714924; rs34610517; rs35597782; rs3075605; rs11424557; rs34152768; rs1079397; rs35905702; rs35583050; rs13354324; rs34833402; rs34139618; rs10036464; rs35220263; rs34215850; rs12653482; rs36036266; rs35130512; rs1717569; rs6862341; rs34830838; rs337889; rs34834944; rs34302981; rs9687115; rs13174426; rs35534569; rs34064696; rs10044381; rs337870; rs35317295; rs9799972; rs13156857; rs688286; rs35371175; rs41380947; rs34208828; rs28376183; rs28880323; rs35365107; rs13356043; rs35320861; rs34239164; rs519616; rs34498684; rs34056138; rs337831; rs35128236; rs34740869; rs35008584; rs34764801; rs34879488; rs16875915; rs28469385; rs35036564; rs35466881; rs35603282; rs13186087; rs34854556; rs34707299; rs338459; rs35697969; rs10044323; rs7707781; rs11387576; rs34904434; rs36187313; rs4704527; rs337873; rs13156748; rs1583874; rs13178011; rs35847346; rs784582; rs13161164; rs35689064; rs11750390; rs10574411; rs35368627; rs35436989; rs34148796; rs34805908; rs3857402; rs34209322; rs36189781; rs35548234; rs35433236; rs35038707; rs34923760; rs36189850; rs34264126; rs7736871; rs35281545; rs5868942; rs35103058; rs34155346; rs36034813; rs34432678; rs36176060; rs35285216; rs35428296; rs36186839; rs34917607; rs4133641; rs7448396; rs35839419; rs34033767; rs2547907; rs4704523; rs13155848; rs28520051; rs35667232; rs7702582; rs34499731; rs573979; rs35701136; rs337869; rs34341146; rs35588382; rs34032086; rs34346174; rs34857061; rs10474571; rs3098694; rs35285752; rs34026363; rs11747782; rs34338496; rs3098687; rs12109560; rs7700275; rs35740556; rs35013980; rs3797551; rs10942871; rs34768794; rs10474003; rs550807; rs2547909; rs34687985; rs7727489; rs337894; rs3114499; rs337839; rs337861; rs4021352; rs36162527; rs10618582; rs10574410; rs35363304; rs35681509; rs3114491; rs9632424; rs35911170; rs13166469; rs3035252; rs11746064; rs36144584; rs13155460; rs34737292; rs13181496; rs34368935; rs34755254; rs3886615; rs13176597; rs28370903; rs35116666; rs7722223; rs1092386; rs16875916; rs35201819; rs35893550; rs638060; rs36027876; rs16876023; rs34309008; rs35089219; rs12656441; rs4703763; rs12187354; rs10697601; rs35332751; rs638073; rs10942876; rs2547906; rs16876000; rs34259925; rs33970298; rs36191751; rs10594012; rs813049; rs337855; rs12109658; rs34574941; rs35025964; rs189804; rs34888064; rs2919652; rs3898436; rs539740; rs10053510; rs34533204; rs7703105; rs7735667; rs337880; rs235041; rs35496004; rs11413324; rs28673689; rs35400790; rs34402312; rs28405288; rs2197000; rs34040242; rs11743312; rs336524; rs6862636; rs394636; rs3098693; rs547170; rs35834955; rs13181505; rs34503367; rs11394259; rs10636559; rs337872; rs34595444; rs4703767; rs34055862; rs10551103; rs28634712; rs11268991; rs3899213; rs34105402; rs35730374; rs34714631; rs180048; rs13155497; rs34990932; rs10053225; rs11954358; rs13177269; rs3839268; rs34445419; rs28635990; rs11355138; rs13176594; rs337837; rs36197411; rs13181497; rs13172645; rs1091882; rs1692205; rs10045716; rs34469310; rs7724106; rs35262260; rs11299499; rs34034331; rs2197002; rs7709470; rs163131; rs35846655; rs34571367; rs2363609; rs337854; rs34898219; rs13177451; rs364620; rs9799962; rs34450984; rs36230002; rs35559177; rs12234098; rs34037585; rs13173889; rs36062148; rs13176845; rs10590311; rs34205498; rs35872703; rs35439643; rs11394958; rs35261341; rs35462751; rs35654714; rs34127515; rs1841991; rs11959213; rs10042203; rs16875943; rs12188269; rs35319484; rs337871; rs784588; rs35631654; rs1020186; rs7711919; rs10713151; rs34955466; rs35241200; rs34046420; rs10474002; rs3898435; rs34632923; rs35516786; rs35783391; rs36182430; rs6873893; rs4703766; rs9800277; rs36099030; rs10462561; rs13190257; rs35605269; rs10060752; rs6867149; rs3098688; rs34768660; rs186836; rs34706909; rs34688578; rs4482882; rs7717318; rs479148; rs35661103; rs35665104; rs35093883; rs13188817; rs34991706; rs7733057; rs5868940; rs10715023; rs13159135; rs11355139; rs6898498; rs1717570; rs7704110; rs35800814; rs35393927; rs3839269; rs894063; rs36146674; rs337868; rs13154740; rs13162166; rs36181206; rs337838; rs35626755; rs235042; rs10713491; rs7706760; rs35397898; rs189258; rs35719104; rs4704540; rs34902218; rs12153761; rs28693862; rs10683109; rs10057066; rs33943364; rs3035249; rs35928774; rs3857403; rs640837; rs3846678; rs4703765; rs35005469; rs2197001; rs34960858; rs8180446; rs7718164; rs34743994; rs10942874; rs35271764; rs35140194; rs12233989; rs36112811; rs3098685; rs10718349; rs2582725; rs4579229; rs10551102; rs7710146; rs35321003; rs9686894; rs35782121; rs5868939; rs34757674; rs34686491; rs486880; rs336522; rs28710792; rs34249973; rs35403493; rs36177025; rs35632995; rs35367883; rs34679554; rs11959212; rs7703437; rs34624505; rs11339765; rs6863008; rs784583; rs28366694; rs337874; rs35743244; rs36172998; rs4623130; rs35365110; rs34562530; rs34239279; rs34607195; rs183509; rs4133640; rs11750483; rs3098689; rs13181535; rs35596391; rs10525745; rs16876144; rs34302396; rs7716141; rs3889702; rs12655680; rs34833921; rs5868941; rs11440743; rs28616200; rs35516119; rs13178897; rs12189199; rs9885047; rs34367819; rs35644734; rs35377010; rs34286642; rs2547908; rs34960514; rs2112908; rs7701762; rs500390; rs35791513; rs35715333; rs34899252; rs34802644; rs13159416; rs35765094; rs7721596; rs13183099; rs13179012; rs497520; rs34221362; rs6887176; rs11272168; rs11308364; rs34016781; rs10068924; rs10514156; rs10942866; rs11742892; rs11747027; rs152727; rs163132; rs163133; rs17218031; rs2020368; rs2029904; rs2132537; rs336525; rs336526; rs337848; rs402208; rs4704521; rs478651; rs663646; rs6863289; rs6863492; rs705415; rs7702025; rs9293761

# Metabolic_Enzyme_2_General_References:
2303452; 1968043; 7687847; 1930244; 1390929; 7628016; 9032078; 1718978; 1550123; 8116615; 8125475; 8541342; 8651289; 9582121; 10036316; 11802522

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5551

# Metabolic_Enzyme_3_Name:
Arylsulfatase D precursor

# Metabolic_Enzyme_3_Synonyms:
ASD

# Metabolic_Enzyme_3_Gene_Name:
ARSD

# Metabolic_Enzyme_3_Protein_Sequence:
>Arylsulfatase D precursor
MRSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYG
NNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNA
GSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTL
TNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLF
FISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSL
LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH
LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPT
VVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKV
HYTTPQFHPEERGLLTAEASAHAEWGGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAV
IARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHEDGDGTP

# Metabolic_Enzyme_3_Number_of_Residues:
593

# Metabolic_Enzyme_3_Molecular_Weight:
65072

# Metabolic_Enzyme_3_Theoretical_pI:
7.10

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Not Available

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Not Available

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_3_Signals:
1-33

# Metabolic_Enzyme_3_Transmembrane_Regions:
206-225; 229-251; 292-314

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.6.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
791002

# Metabolic_Enzyme_3_SwissProt_ID:
ARSD_HUMAN (P51689)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ARSD

# Metabolic_Enzyme_3_Geneatlas_id:
ARSD

# Metabolic_Enzyme_3_hgnc_id:
HGNC:717

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Lysosome (Potential)

# Metabolic_Enzyme_3_Gene_Sequence:
>1782 bp
ATGCGATCCGCCGCGCGGAGGGGACGCGCCGCGCCCGCCGCCAGGGACTCTTTGCCGGTG
CTACTGTTTTTATGCTTGCTTCTGAAGACGTGTGAACCTAAAACTGCAAATGCCTTTAAA
CCAAATATCCTACTGATCATGGCGGATGATCTAGGCACTGGGGATCTCGGTTGCTACGGG
AACAATACACTGAGAACGCCGAATATTGACCAGCTTGCAGAGGAAGGTGTGAGGCTCACT
CAGCACCTGGCGGCCGCCCCGCTCTGCACCCCAAGCCGAGCTGCATTCCTCACAGGGAGA
CATTCCTTCAGATCAGGCATGGACGCCAGCAATGGATACCGGGCCCTTCAGTGGAACGCA
GGCTCAGGTGGACTCCCTGAGAACGAAACCACTTTTGCAAGAATCTTGCAGCAGCATGGC
TATGCAACCGGCCTCATAGGAAAATGGCACCAGGGTGTGAATTGTGCATCCCGCGGGGAT
CACTGCCACCACCCCCTGAACCACGGATTTGACTATTTCTACGGCATGCCCTTCACGCTC
ACAAACGACTGTGACCCAGGCAGGCCCCCCGAAGTGGACGCCGCCCTGAGGGCGCAGCTC
TGGGGTTACACCCAGTTCCTGGCGCTGGGGATTCTCACCCTGGCTGCCGGCCAGACCTGC
GGTTTCTTCTCTGTCTCCGCGAGAGCAGTCACCGGCATGGCCGGCGTGGGCTGCCTGTTT
TTCATCTCTTGGTACTCCTCCTTCGGGTTTGTGCGACGCTGGAACTGTATCCTGATGAGA
AACCATGACGTCACGGAGCAACCCATGGTTCTGGAGAAAACAGCGAGTCTTATGCTAAAG
GAAGCTGTTTCCTATATTGAAAGACACAAGCATGGGCCATTTCTCCTCTTCCTTTCTTTG
CTGCATGTGCACATTCCCCTTGTGACCACGAGTGCATTCCTGGGGAAAAGTCAGCATGGC
TTATATGGTGATAATGTGGAGGAGATGGACTGGCTCATAGGTAAGGTTCTTAATGCCATC
GAAGACAATGGTTTAAAGAACTCAACATTCACGTATTTCACCTCTGACCATGGAGGACAT
TTAGAGGCAAGAGATGGACACAGCCAGTTAGGGGGATGGAACGGAATTTACAAAGGTGGG
AAGGGCATGGGAGGATGGGAAGGTGGGATCCGAGTGCCCGGGATCTTCCACTGGCCGGGG
GTGCTCCCGGCCGGCCGAGTGATTGGAGAGCCCACGAGCCTGATGGACGTGTTCCCTACT
GTGGTCCAGCTGGTGGGTGGCGAGGTGCCCCAGGACAGGGTGATTGATGGCCACAGCCTG
GTACCCTTGCTGCAGGGAGCTGAGGCACGCTCGGCACATGAGTTCCTGTTTCATTACTGT
GGGCAGCATCTTCACGCAGCACGCTGGCACCAGAAGGACAGTGGAAGCGTCTGGAAGGTT
CATTACACGACCCCGCAGTTCCACCCCGAGGAGCGGGGCCTGCTAACGGCCGAGGCGTCT
GCCCATGCTGAATGGGGAGGCGTGACCCATCACAGACCCCCTTTGCTCTTTGACCTCTCC
AGGGACCCCTCCGAGGCACGGCCCCTGACCCCCGACTCCGAGCCCCTGTACCACGCCGTG
ATAGCAAGGGTAGGTGCCGCGGTGTCGGAGCATCGGCAGACCCTGAGTCCTGTGCCCCAG
CAGTTTTCCATGAGCAACATCCTGTGGAAGCCGTGGCTGCAGCCGTGCTGCGGACATTTC
CCGTTCTGTTCATGCCACGAGGATGGGGATGGCACCCCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X83572

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_3_Locus:
Xp22.3

# Metabolic_Enzyme_3_SNPs:
rs211653; rs211648; rs2228431; rs34494682; rs2229557; rs2228433; rs35096299; rs2302076; rs9334; rs211647; rs5939146; rs5939392; rs12388793; rs7884079; rs1043269; rs1043270; rs17331014; rs1043272; rs211649; rs12846104; rs5982920; rs6642066; rs4892908; rs2302077; rs5939397; rs1637781; rs1637779; rs1637777; rs12013334; rs4892907; rs6642067; rs1637776; rs3747394; rs5939398; rs3747393; rs1124546; rs5939399; rs5982919; rs5982617; rs211651; rs5939400; rs3747395; rs5982616; rs3827454; rs5982916; rs6567682; rs5982609; rs5982610; rs3747397; rs5982611; rs4141210; rs17335121; rs4141211; rs41302629; rs41311465; rs41302625; rs5939391; rs11538097; rs1138618; rs11556962; rs5982917; rs34210921; rs1138619; rs10634744; rs3078565; rs3747396; rs10218035; rs11556963; rs5982922; rs35837588; rs10555820; rs34910956; rs41308439; rs5982615; rs5939395; rs7053429; rs7065372; rs5982921; rs169829; rs11403125; rs34925283; rs5939147; rs10555819; rs12836012; rs35033726; rs1847214; rs211650; rs5939396; rs5982614; rs1698812; rs28587311; rs41297279; rs10624089; rs6642068; rs1637774; rs1627688; rs188430; rs34494989; rs5939148; rs7357997; rs211652; rs5982613; rs1502873; rs41302607; rs5939393; rs5982923; rs186112; rs5982918; rs4451470; rs1637780; rs1637778; rs10624690; rs34368255; rs5939401; rs1698814; rs41310266; rs35787994; rs5982914; rs7884701; rs35372805; rs7889616; rs3833415; rs7884791; rs7053284; rs5982915; rs11152554; rs12852742; rs5982606; rs5982911

# Metabolic_Enzyme_3_General_References:
7720070; 11177574

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5554

# Metabolic_Enzyme_4_Name:
Galactosylceramide sulfotransferase

# Metabolic_Enzyme_4_Synonyms:
GalCer sulfotransferase; Cerebroside sulfotransferase; 3'- phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; 3'- phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase

# Metabolic_Enzyme_4_Gene_Name:
GAL3ST1

# Metabolic_Enzyme_4_Protein_Sequence:
>Galactosylceramide sulfotransferase
MLPPQKKPWESMAKGLVLGALFTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPALEPE
AVIRANGSAGECQPRRNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNGRNDFDYPTF
FARSLVQDYRPGACFNIICNHMRFHYDEVRGLVPTNAIFITVLRDPARLFESSFHYFGPV
VPLTWKLSAGDKLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQVQEHIL
EVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAW
NMLDSHLYRHFNASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHAVDAAAIQDE
AMQPWQPLGTKSILGYNLKKSIGQRHAQLCRRMLTPEIQYLMDLGANLWVTKLWKFIRDF
LRW

# Metabolic_Enzyme_4_Number_of_Residues:
423

# Metabolic_Enzyme_4_Molecular_Weight:
48765

# Metabolic_Enzyme_4_Theoretical_pI:
8.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
Function:  galactose 3-O-sulfotransferase activity
Function:  galactosylceramide sulfotransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  Golgi apparatus

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the nonreducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)

# Metabolic_Enzyme_4_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_4_Reaction:
3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF06990:Gal-3-0_sulfotr

# Metabolic_Enzyme_4_Signals:
1-33

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.8.2.11

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1871141

# Metabolic_Enzyme_4_SwissProt_ID:
G3ST1_HUMAN (Q99999)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GAL3ST1

# Metabolic_Enzyme_4_Geneatlas_id:
GAL3ST1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:24240

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>1272 bp
ATGCTGCCACCGCAGAAGAAGCCCTGGGAGTCCATGGCTAAGGGGCTGGTGCTGGGCGCG
CTCTTCACTAGTTTCCTGCTGCTGGTGTACTCCTATGCCGTGCCCCCGCTGCATGCCGGC
CTGGCCTCCACGACCCCGGAGGCCGCAGCGTCCTGCTCTCCACCTGCACTCGAGCCAGAG
GCAGTGATCCGGGCCAACGGCTCGGCGGGGGAGTGCCAGCCGCGGCGCAACATCGTGTTC
TTGAAGACGCACAAGACGGCCAGCAGCACCCTGCTCAACATCCTGTTCCGCTTCGGCCAG
AAGCACCGGCTCAAGTTCGCCTTCCCTAACGGCCGCAATGACTTCGACTACCCGACCTTC
TTCGCCCGCAGCCTGGTGCAGGACTATCGGCCCGGGGCCTGCTTCAACATCATCTGCAAC
CACATGCGCTTCCACTACGACGAGGTGCGCGGCCTGGTGCCGACCAACGCCATCTTCATC
ACGGTGCTCCGCGACCCCGCCCGCTTGTTCGAGTCCTCCTTCCACTACTTCGGGCCGGTG
GTGCCCCTCACGTGGAAGCTCTCGGCCGGCGACAAGCTGACCGAGTTCCTGCAAGACCCG
GATCGCTACTACGACCCCAACGGCTTCAATGCCCACTACCTCCGAAACCTGCTCTTCTTC
GACCTGGGCTATGACAACAGCCTGGACCCCAGCAGCCCGCAGGTGCAGGAGCACATCCTG
GAGGTGGAGCGTCGCTTCCACCTGGTGCTCCTTCAAGAGTACTTCGACGAGTCGCTGGTG
CTGCTGAAGGACCTGCTGTGCTGGGAGCTGGAGGACGTGCTCTACTTCAAGCTCAACGCC
CGCCGCGACTCGCCCGTGCCGCGGCTCTCGGGGGAGCTGTATGGGCGCGCCACCGCCTGG
AACATGCTGGACTCCCACCTCTACCGCCACTTCAACGCCAGCTTCTGGCGCAAGGTGGAG
GCCTTCGGGCGGGAGCGCATGGCCCGCGAGGTGGCCGCCCTGCGCCATGCCAACGAGCGC
ATGCGGACCATCTGCATCGACGGGGGCCACGCCGTGGACGCCGCCGCCATCCAGGACGAG
GCCATGCAGCCCTGGCAGCCGCTGGGCACCAAGTCCATCCTGGGCTACAACCTCAAGAAG
AGCATCGGGCAGCGGCACGCGCAGCTCTGCCGGCGCATGCTCACGCCCGAGATCCAGTAC
CTGATGGACCTCGGCGCCAACCTGTGGGTCACCAAGCTCTGGAAGTTCATTCGCGATTTC
CTGCGGTGGTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D88667

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_4_Locus:
22q12.2

# Metabolic_Enzyme_4_SNPs:
rs2267161; rs5994320; rs4149488; rs4149490; rs12627772; rs42931; rs5994319; rs11912600; rs42929; rs16988782; rs5994321; rs42930; rs5749128; rs4149491; rs42928; rs2267159; rs42934; rs8142452; rs42932; rs42935; rs6518702; rs4820867; rs11704774; rs42933; rs2267158; rs4149486; rs4149493; rs42927; rs12628608; rs35336481; rs5749126; rs1015468; rs7286285; rs35997653; rs35424902; rs2528451; rs7287502; rs35703060; rs4149487; rs2528453; rs9606753; rs11307372; rs35696153; rs28700236; rs4149489; rs2412992; rs34728518; rs5844912; rs1015467; rs5844911; rs12159375; rs35211752; rs2528461; rs28838736; rs2528462; rs35908001; rs2528452; rs9606754; rs10711898; rs28636681; rs42926; rs34136895; rs9608988; rs2267160; rs12172153; rs11705676; rs9606752; rs35589021; rs1011897; rs35029608; rs2859472; rs35533918; rs5997684; rs13057430; rs9608981; rs35670229; rs35962480; rs16988790; rs2517987; rs2517991; rs2517993; rs2528454; rs2528457; rs2528458; rs2528459; rs2528460; rs42938; rs42939; rs5749124; rs5997681; rs956257; rs9621019

# Metabolic_Enzyme_4_General_References:
9030544; 10785389; 8830034

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5556

# Metabolic_Enzyme_5_Name:
Arylsulfatase A precursor

# Metabolic_Enzyme_5_Synonyms:
ASA; Cerebroside-sulfatase[Contains: Arylsulfatase A component B; Arylsulfatase A component C]

# Metabolic_Enzyme_5_Gene_Name:
ARSA

# Metabolic_Enzyme_5_Protein_Sequence:
>Arylsulfatase A precursor
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT
DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM
AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP
LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE
RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC
GKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP
LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL
TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG
EDPALQICCHPGCTPRPACCHCPDPHA

# Metabolic_Enzyme_5_Number_of_Residues:
507

# Metabolic_Enzyme_5_Molecular_Weight:
53589

# Metabolic_Enzyme_5_Theoretical_pI:
6.01

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  sulfuric ester hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
Hydrolyzes cerebroside sulfate

# Metabolic_Enzyme_5_Pathway:
map00600  Glycosphingolipid metabolism

# Metabolic_Enzyme_5_Reaction:
A cerebroside 3-sulfate + H2O = a cerebroside + sulfate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00884:Sulfatase

# Metabolic_Enzyme_5_Signals:
1-18

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.6.8

# Metabolic_Enzyme_5_GenBank_ID_Protein:
28858

# Metabolic_Enzyme_5_SwissProt_ID:
ARSA_HUMAN (P15289)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ARSA

# Metabolic_Enzyme_5_Geneatlas_id:
ARSA

# Metabolic_Enzyme_5_hgnc_id:
HGNC:713

# Metabolic_Enzyme_5_PDB_ID:
1E2S

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_5_Gene_Sequence:
>1524 bp
ATGGGGGCACCGCGGTCCCTCCTCCTGGCCCTGGCTGCTGGCCTGGCCGTTGCCCGTCCG
CCCAACATCGTGCTGATCTTTGCCGACGACCTCGGCTATGGGGACCTGGGCTGCTATGGG
CACCCCAGCTCTACCACTCCCAACCTGGACCAGCTGGCGGCGGGAGGGCTGCGGTTCACA
GACTTCTACGTGCCTGTGTCTCTGTGCACACCCTCTAGGGCCGCCCTCCTGACCGGCCGG
CTCCCGGTTCGGATGGGCATGTACCCTGGCGTCCTGGTGCCCAGCTCCCGGGGGGGCCTG
CCCCTGGAGGAGGTGACCGTGGCCGAAGTCCTGGCTGCCCGAGGCTACCTCACAGGAATG
GCCGGCAAGTGGCACCTTGGGGTGGGGCCTGAGGGGGCCTTCCTGCCCCCCCATCAGGGC
TTCCATCGATTTCTAGGCATCCCGTACTCCCACGACCAGGGCCCCTGCCAGAACCTGACC
TGCTTCCCGCCGGCCACTCCTTGCGACGGTGGCTGTGACCAGGGCCTGGTCCCCATCCCA
CTGTTGGCCAACCTGTCCGTGGAGGCGCAGCCCCCCTGGCTGCCCGGACTAGAGGCCCGC
TACATGGCTTTCGCCCATGACCTCATGGCCGACGCCCAGCGCCAGGATCGCCCCTTCTTC
CTGTACTATGCCTCTCACCACACCCACTACCCTCAGTTCAGTGGGCAGAGCTTTGCAGAG
CGTTCAGGCCGCGGGCCATTTGGGGACTCCCTGATGGAGCTGGATGCAGCTGTGGGGACC
CTGATGACAGCCATAGGGGACCTGGGGCTGCTTGAAGAGACGCTGGTCATCTTCACTGCA
GACAATGGACCTGAGACCATGCGTATGTCCCGAGGCGGCTGCTCCGGTCTCTTGCGGTGT
GGAAAGGGAACGACCTACGAGGGCGGTGTCCGAGAGCCTGCCTTGGCCTTCTGGCCAGGT
CATATCGCTCCCGGCGTGACCCACGAGCTGGCCAGCTCCCTGGACCTGCTGCCTACCCTG
GCAGCCCTGGCTGGGGCCCCACTGCCCAATGTCACCTTGGATGGCTTTGACCTCAGCCCC
CTGCTGCTGGGCACAGGCAAGAGCCCTCGGCAGTCTCTCTTCTTCTACCCGTCCTACCCA
GACGAGGTCCGTGGGGTTTTTGCTGTGCGGACTGGAAAGTACAAGGCTCACTTCTTCACC
CAGGGCTCTGCCCACAGTGATACCACTGCAGACCCTGCCTGCCACGCCTCCAGCTCTCTG
ACTGCTCATGAGCCCCCGCTGCTCTATGACCTGTCCAAGGACCCTGGTGAGAACTACAAC
CTGCTGGGGGGTGTGGCCGGGGCCACCCCAGAGGTGCTGCAAGCCCTGAAACAGCTTCAG
CTGCTCAAGGCCCAGTTAGACGCAGCTGTGACCTTCGGCCCCAGCCAGGTGGCCCGGGGC
GAGGACCCCGCCCTGCAGATCTGCTGTCATCCTGGCTGCACCCCCCGCCCAGCTTGCTGC
CATTGCCCAGATCCCCATGCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X52151

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_5_Locus:
22q13.31-qter|22q13.33

# Metabolic_Enzyme_5_SNPs:
rs2071421; rs743616; rs6151415; rs6151427; rs6151428; rs6151425; rs6151412; rs6151410; rs6151408; rs6151429; rs6151406; rs873697; rs6151424; rs6151419; rs6151423; rs6151420; rs762672; rs1106788; rs762673; rs6151421; rs6151413; rs6151418; rs6151416; rs5741862; rs131713; rs7288338; rs5770953; rs762668; rs6520160; rs6520159; rs131714; rs6520161; rs7288050; rs8142033; rs131715; rs6151403; rs6151405; rs5770805; rs28940894; rs28940893; rs6151422; rs28940895; rs6151411; rs34457249; rs1051539; rs6151407; rs34636260; rs6151426; rs5030763; rs6151414; rs6151409; rs9616801; rs6151417; rs2879913; rs8139846; rs8138770; rs35519140; rs7290199; rs35894766; rs34290947; rs34367180; rs6010033; rs4040040; rs35005618; rs13054262; rs34233484; rs131717; rs34969940; rs131716; rs2879912; rs2341003; rs3043715; rs8137818; rs34890441; rs8142531; rs6010032; rs6009939; rs34043300; rs2341004; rs34618802; rs36019124; rs6151404; rs11704557; rs131710; rs131718; rs131724; rs131728; rs3091400; rs5770963; rs762674; rs8137781; rs9616802

# Metabolic_Enzyme_5_General_References:
2562955; 1975241; 10591208; 1352993; 7628016; 9521684; 11124905; 7866401; 1353340; 1678251; 1673291; 1670590; 7902317; 7860068; 8101083; 8104633; 8101038; 2574462; 8095918; 7906588; 7581401; 8723680; 9090526; 9490297; 9600244; 9452102; 9744473; 9888390; 10220151

# Metabolic_Enzyme_5_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7533

# Macromolecular_Interacting_Partner_1_Name:
Coagulation factor XII precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Hageman factor; HAF[Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain]

# Macromolecular_Interacting_Partner_1_Gene_Name:
F12

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Coagulation factor XII precursor
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGPFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
615

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
67819

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.76

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha- factor XIIa activates factor XI to factor XIa

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00008:EGF;
PF00039:fn1;
PF00040:fn2;
PF00051:Kringle;
PF00089:Trypsin

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 3.4.21.38

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
180357

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
FA12_HUMAN (P00748)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
F12

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
F12

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3530

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1848 bp
ATGAGGGCTCTGCTGCTCCTGGGGTTCCTGCTGGTGAGCTTGGAGTCAACACTTTCGATT
CCACCTTGGGAAGCCCCCAAGGAGCATAAGTACAAAGCTGAAGAGCACACAGTCGTTCTC
ACTGTCACCGGGGAGCCCTGCCACTTCCCCTTCCAGTACCACCGGCAGCTGTACCACAAA
TGTACCCACAAGGGCCGGCCAGGCCCTCAGCCCTGGTGTGCTACCACCCCCAACTTTGAT
CAGGACCAGCGATGGGGATACTGTTTGGAGCCCAAGAAAGTGAAAGACCACTGCAGCAAA
CACAGCCCCTGCCAGAAAGGAGGGACCTGTGTGAACATGCCAAGCGGCCCCCACTGTCTC
TGTCCACAACACCTCACTGGAAACCACTGCCAGAAAGAGAAGTGCTTTGAGCCTCAGCTT
CTCCGGTTTTTCCACAAGAATGAGATATGGTATAGAACTGAGCAAGCAGCTGTGGCCAGA
TGCCAGTGCAAGGGTCCTGATGCCCACTGCCAGCGGCTGGCCAGCCAGGCCTGCCGCACC
AACCCGTGCCTCCATGGGGGTCGCTGCCTAGAGGTGGAGGGCCACCGCCTGTGCCACTGC
CCGGTGGGCTACACCGGACCCTTCTGCGACGTGGACACCAAGGCAAGCTGCTATGATGGC
CGCGGGCTCAGCTACCGCGGCCTGGCCAGGACCACGCTCTCGGGTGCGCCCTGTCAGCCG
TGGGCCTCGGAGGCCACCTACCGGAACGTGACTGCCGAGCAAGCGCGGAACTGGGGACTG
GGCGGCCACGCCTTCTGCCGGAACCCGGACAACGACATCCGCCCGTGGTGCTTCGTGCTG
AACCGCGACCGGCTGAGCTGGGAGTACTGCGACCTGGCACAGTGCCAGACCCCAACCCAG
GCGGCGCCTCCGACCCCGGTGTCCCCTAGGCTTCATGTCCCACTCATGCCCGCGCAGCCG
GCACCGCCGAAGCCTCAGCCCACGACCCGGACCCCGCCTCAGTCCCAGACCCCGGGAGCC
TTGCCGGCGAAGCGGGAGCAGCCGCCTTCCCTGACCAGGAACGGCCCACTGAGCTGCGGG
CAGCGGCTCCGCAAGAGTCTGTCTTCGATGACCCGCGTCGTTGGCGGGCTGGTGGCGCTA
CGCGGGGCGCACCCCTACATCGCCGCGCTGTACTGGGGCCACAGTTTCTGCGCCGGCAGC
CTCATCGCCCCCTGCTGGGTGCTGACGGCCGCTCACTGCCTGCAGGACCGGCCCGCACCC
GAGGATCTGACGGTGGTGCTCGGCCAGGAACGCCGTAACCACAGCTGTGAGCCGTGCCAG
ACGTTGGCCGTGCGCTCCTACCGCTTGCACGAGGCCTTCTCGCCCGTCAGCTACCAGCAC
GACCTGGCTCTGTTGCGCCTTCAGGAGGATGCGGACGGCAGCTGCGCGCTCCTGTCGCCT
TACGTTCAGCCGGTGTGCCTGCCAAGCGGCGCCGCGCGACCCTCCGAGACCACGCTCTGC
CAGGTGGCCGGCTGGGGCCACCAGTTCGAGGGGGCGGAGGAATATGCCAGCTTCCTGCAG
GAGGCGCAGGTACCGTTCCTCTCCCTGGAGCGCTGCTCAGCCCCGGACGTGCACGGATCC
TCCATCCTCCCCGGCATGCTCTGCGCAGGGTTCCTCGAGGGCGGCACCGATGCGTGCCAG
GGTGATTCCGGAGGCCCGCTGGTGTGTGAGGACCAAGCTGCAGAGCGCCGGCTCACCCTG
CAAGGCATCATCAGCTGGGGATCGGGCTGTGGTGACCGCAACAAGCCAGGCGTCTACACC
GATGTGGCCTACTACCTGGCCTGGATCCGGGAGCACACCGTTTCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M17466

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q33-qter

# Macromolecular_Interacting_Partner_1_SNPs:
rs2230938; rs17876030; rs2230939; rs17876047; rs17876033; rs1801020; rs4976648; rs7709674; rs4976692; rs17876019; rs17876025; rs17876044; rs17876020; rs17876031; rs17876018; rs17876032; rs4314418; rs17876046; rs6556321; rs17876045; rs17876048; rs17876026; rs4976649; rs17876027; rs17876014; rs17876028; rs17876015; rs6556320; rs2252316; rs1363352; rs17876040; rs2731676; rs2252317; rs17875996; rs17876006; rs6420096; rs17875997; rs6420097; rs17876003; rs7381103; rs35515200; rs17876034; rs41309748; rs41309750; rs41309752; rs41309746; rs34232995; rs41309134; rs33943360; rs41309138; rs34662844; rs36095913; rs41309754; rs17876010; rs35398840; rs35966430; rs41309136; rs35850757; rs41309140; rs34321750; rs17876017; rs11741335; rs17876013; rs17876029; rs41309760; rs17876016; rs17876012; rs17876041; rs17876005; rs17876007; rs17876043; rs41309132; rs17876042; rs34097461; rs41309762; rs41309756; rs11750450; rs17876038; rs2070853; rs2545801; rs2731672; rs2731675; rs34044544; rs34225933; rs4074057; rs4076508; rs4976691; rs6862195; rs6869526; rs7379524; rs7447593

# Macromolecular_Interacting_Partner_1_General_References:
2888762; 3754331; 3877053; 3011063; 3886654; 6604055; 8528215; 1544894; 2510163; 8049433; 10361128

# Macromolecular_Interacting_Partner_1_References:
10052595; 15173196; 2861197; 3169363

# Macromolecular_Interacting_Partner_2_ID:
7542

# Macromolecular_Interacting_Partner_2_Name:
Kininogen-1 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Alpha-2-thiol proteinase inhibitor[Contains: Kininogen-1 heavy chain; Bradykinin; Kallidin I; Lysyl-bradykinin; Kallidin II; Kininogen-1 light chain; Low molecular weight growth- promoting factor]

# Macromolecular_Interacting_Partner_2_Gene_Name:
KNG1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Kininogen1 precursor
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRIT
EATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFS
VATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLN
EVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLR
IASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFK
IDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPW
EKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSG
KEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLD
DDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQE
KTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSF
NPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
644

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
71958

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.80

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  cysteine protease inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects:(4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00031:Cystatin

# Macromolecular_Interacting_Partner_2_Signals:
1-18

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
177890

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
KNG1_HUMAN (P01042)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
KNG1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
KNG1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6383

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein; extracellular space

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1284 bp
ATGAAACTAATTACCATCCTTTTCCTCTGCTCCAGGCTACTACTAAGTTTAACCCAGGAA
TCACAGTCCGAGGAAATTGACTGCAATGACAAGGATTTATTTAAAGCTGTGGATGCTGCT
CTGAAGAAATATAACAGTCAAAACCAAAGTAACAACCAGTTTGTATTGTACCGCATAACT
GAAGCCACTAAGACGGTTGGCTCTGACACGTTTTATTCCTTCAAGTACGAAATCAAGGAG
GGGGATTGTCCTGTTCAAAGTGGCAAAACCTGGCAGGACTGTGAGTACAAGGATGCTGCA
AAAGCAGCCACTGGAGAATGCACGGCAACCGTGGGGAAGAGGAGCAGTACGAAATTCTCC
GTGGCTACCCAGACCTGCCAGATTACTCCAGCCGAGGGCCCTGTGGTGACAGCCCAGTAC
GACTGCCTCGGCTGTGTGCATCCTATATCAACGCAGAGCCCAGACCTGGAGCCCATTCTG
AGACACGGCATTCAGTACTTTAACAACAACACTCAACATTCCTCCCTCTTCATGCTTAAT
GAAGTAAAACGGGCCCAAAGACAGGTGGTGGCTGGATTGAACTTTCGAATTACCTACTCA
ATTGTGCAAACGAATTGTTCCAAAGAGAATTTTCTGTTCTTAACTCCAGACTGCAAGTCC
CTTTGGAATGGTGATACCGGTGAATGTACAGATAATGCATACATCGATATTCAGCTACGA
ATTGCTTCCTTCTCACAGAACTGTGACATTTATCCAGGGAAGGATTTTGTACAACCACCT
ACCAAGATTTGCGTGGGCTGCCCCAGAGATATACCCACCAACAGCCCAGAGCTGGAGGAG
ACACTGACTCACACCATCACAAAGCTTAATGCAGAGAATAACGCAACTTTCTATTTCAAG
ATTGACAATGTGAAAAAAGCAAGAGTACAGGTGGTGGCTGGCAAGAAATATTTTATTGAC
TTCGTGGCCAGGGAAACCACATGTTCCAAGGAAAGTAATGAAGAGTTGACCGAAAGCTGT
GAGACCAAAAAACTTGGCCAAAGCCTAGATTGCAACGCTGAAGTTTATGTGGTACCCTGG
GAGAAAAAAATTTACCCTACTGTCAACTGTCAACCACTGGGAATGATCTCACTGATGAAA
AGGCCTCCAGGTTTTTCACCTTTCCGATCATCACGAATAGGGGAAATAAAAGAAGAAACA
ACTAGTCACCTAAGGTCCTGCGAGTACAAGGGTCGACCCCCAAAGGCAGGGGCAGAGCCA
GCATCTGAGAGGGAGGTCTCTTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
K02566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_2_Locus:
3q27

# Macromolecular_Interacting_Partner_2_SNPs:
rs2304456; rs5030024; rs1656922; rs5030015; rs1469859; rs5029980; rs1050274; rs5030096; rs5029974; rs1656925; rs2378115; rs1648698; rs5030072; rs710448; rs266760; rs1648697; rs5030022; rs1624569; rs5030023; rs5030002; rs5029999; rs5029979; rs5030020; rs5030094; rs1648722; rs1656914; rs698078; rs1851665; rs5030057; rs5030039; rs5029988; rs5030032; rs1656912; rs5030045; rs5030095; rs1829886; rs1656918; rs5030103; rs1851664; rs5030087; rs5030018; rs5030063; rs1648715; rs5030089; rs5029991; rs4686798; rs1656921; rs5030107; rs5029985; rs5029990; rs1656942; rs1624230; rs1622922; rs5030053; rs5030106; rs1648700; rs5030052; rs5029986; rs822366; rs5030076; rs5030092; rs5030059; rs710449; rs5029992; rs5030011; rs5030069; rs5030043; rs5030028; rs710447; rs5030111; rs3190571; rs822363; rs2689197; rs5030004; rs1621816; rs5030083; rs710446; rs5030051; rs2651640; rs1648716; rs5029987; rs5030033; rs1656910; rs1403694; rs1648712; rs166479; rs7644084; rs1836860; rs5030081; rs5030113; rs5030084; rs1656917; rs822620; rs822624; rs2304451; rs5030068; rs822364; rs5030048; rs5030041; rs266724; rs5030090; rs5030108; rs5030074; rs2304452; rs5030037; rs5030026; rs5030001; rs5030082; rs5030049; rs3841557; rs1656909; rs5030042; rs1656926; rs5030079; rs5030035; rs1656911; rs1648711; rs2062632; rs822362; rs5030031; rs5030025; rs1656920; rs5030088; rs5030012; rs5030085; rs266725; rs5030075; rs5029981; rs3856930; rs1648714; rs5030102; rs5030017; rs5030064; rs5030066; rs5030065; rs5029976; rs5030003; rs4686439; rs5030029; rs5030046; rs5030038; rs5030009; rs5029997; rs4686799; rs2651641; rs1656908; rs5030061; rs5030014; rs5030115; rs5030086; rs1656919; rs1656916; rs5030016; rs5030060; rs5029982; rs5029989; rs5029996; rs5030047; rs5030093; rs5030058; rs5030070; rs5029993; rs1648699; rs5029977; rs5030067; rs1648713; rs2304455; rs5029998; rs5030091; rs266723; rs5030044; rs5030109; rs5030104; rs5030062; rs5030050; rs5030073; rs5029978; rs1656915; rs5030027; rs5030099; rs5029994; rs5030036; rs13317089; rs11917445; rs5030071; rs5030078; rs5030054; rs5030080; rs5030112; rs1523435; rs5029975; rs2304454; rs5029995; rs865880; rs5030101; rs5029983; rs5030105; rs5030056; rs5030034; rs5030019; rs5030008; rs266726; rs9869244; rs5030077; rs4686800; rs11929295; rs5030100; rs5030021; rs5030013; rs5030114; rs13084325; rs5030055; rs9882598; rs5030000; rs5030110; rs13098645; rs10440056; rs3774291; rs2651639; rs5029973; rs5029970; rs3806688; rs5029969; rs3774292; rs3821815; rs3806689; rs5029971; rs10439971; rs17838879; rs10440057; rs5029972; rs10439970; rs33934143; rs13072823; rs36121564; rs9866324; rs11328552; rs28461768; rs11276552; rs28607874; rs35578318; rs1212217; rs34098137; rs10571187; rs822365; rs35995617; rs10531727; rs11425592; rs11425593; rs35477316; rs35079146; rs34693243; rs13095338; rs1209472; rs34650598; rs13062473; rs28496811; rs13072436; rs35957661; rs10575985; rs13072694; rs34231414; rs9877452; rs10703695; rs10575988; rs10576660; rs34707597; rs34208952; rs35394339; rs11275829; rs11057; rs11328550; rs10662949; rs9818796; rs34957759; rs1656927; rs9825929; rs12635879; rs35569041; rs13063282; rs2912567; rs34651871; rs1211468; rs28390219; rs9819941; rs10575986; rs13095484; rs2304453; rs9851780; rs11328551; rs35025634; rs5030030; rs192371; rs13083619; rs35668151; rs35596301; rs13085884; rs13072546; rs9812764; rs11394050; rs3217421; rs13072563; rs35138120; rs34745532; rs13065593; rs10575987; rs35823469; rs34728507; rs35667207; rs10571591; rs35425194; rs2651642; rs35065127; rs3836479; rs10702686; rs11297934; rs1648717; rs36160200; rs10513803; rs10937264; rs10937265; rs10937266; rs11712801; rs11918289; rs11924390; rs11927941; rs12491806; rs12497377; rs12629364; rs13098570; rs13315296; rs1392952; rs1656939; rs1656940; rs1656966; rs1972703; rs2033122; rs266721; rs266722; rs266762; rs266763; rs266764; rs266767; rs34358682; rs35557208; rs35853604; rs4615069; rs4686436; rs5030097; rs5030098; rs6796803; rs6807774; rs7624355; rs7647509; rs822368; rs822370; rs822371; rs822373; rs905056; rs905057; rs961010; rs9817038; rs9838998; rs9852828

# Macromolecular_Interacting_Partner_2_General_References:
6441591; 2989293; 4054110; 4952632; 3484703; 3366244; 7589467; 2989294; 3182782; 12754519

# Macromolecular_Interacting_Partner_2_References:
3436959; 3928613

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
10570222; 11445552; 12145165; 14707487

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
12885578; 16143863; 1649796; 9119455

# Macromolecular_Interacting_Partner_5_ID:
7121

# Macromolecular_Interacting_Partner_5_Name:
Myelin basic protein

# Macromolecular_Interacting_Partner_5_Synonyms:
MBP; Myelin A1 protein; Myelin membrane encephalitogenic protein

# Macromolecular_Interacting_Partner_5_Gene_Name:
MBP

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Myelin basic protein
MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQ
DTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTI
QEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFG
GDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG
RGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSP
MARR

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
304

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
33117

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.46

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  structural molecule activity
Function:  structural constituent of myelin sheath
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01669:Myelin_MBP

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
307159

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
MBP_HUMAN (P02686)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
MBP

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
MBP

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6925

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Myelin membrane; peripheral membrane protein; cytoplasmic side. Note=Cytoplasmic side of myelin

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>483 bp
ATGGCGTCACAGAAGAGACCCTCCCAGAGGCACGGATCCAAGTACCTGGCCACAGCAAGT
ACCATGGACCATGCCAGGCATGGCTTCCTCCCAAGGCACAGAGACACGGGCATCCTTGAC
TCCATCGGGCGCTTCTTTGGCGGTGACAGGGGTGCGCCCAAGCGGGGCTCTGGCAAGGAC
TCACACCACCCGGCAAGAACTGCTCACTACGGCTCCCTGCCCCAGAAGTCACACGGCCGG
ACCCAAGATGAAAACCCCGTAGTCCACTTCTTCAAGAACATTGTGACGCCTCGCACACCA
CCCCCGTCGCAGGGAAAGGGGGCCGAAGGCCAGAGACCAGGATTTGGCTACGGAGGCAGA
GCGTCCGACTATAAATCGGCTCACAAGGGATTCAAGGGAGTCGATGCCCAGGGCACGCTT
TCCAAAATTTTTAAGCTGGGAGGAAGAGATAGTCGCTCTGGATCACCCATGGCTAGACGC
TGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M30047

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_5_Locus:
18q23

# Macromolecular_Interacting_Partner_5_SNPs:
rs470797; rs12406; rs470279; rs470717; rs9199; rs470933; rs17026; rs470822; rs470181; rs4890796; rs2279080; rs1789087; rs7232502; rs9967506; rs1789079; rs1049004; rs470554; rs1617144; rs470724; rs470821; rs1629089; rs7244713; rs2279078; rs470823; rs470555; rs7229288; rs470826; rs7236968; rs6565924; rs470546; rs1789090; rs1667905; rs2279079; rs1048947; rs1789092; rs1048871; rs8083543; rs8083056; rs17060173; rs2282557; rs1375967; rs1632498; rs1789088; rs966080; rs12959006; rs1667920; rs470938; rs12970928; rs1617173; rs470550; rs8094950; rs1450190; rs11660113; rs12456940; rs1789082; rs470213; rs12605040; rs1667908; rs1789080; rs12606687; rs3752069; rs1632516; rs1630958; rs2282569; rs470180; rs9959403; rs11876362; rs4890897; rs1789081; rs12454672; rs11874174; rs1115014; rs1789091; rs1789093; rs12457502; rs10454721; rs2406727; rs1789086; rs731091; rs12454662; rs470871; rs9319657; rs1789089; rs731725; rs8089193; rs11664489; rs470241; rs470473; rs470250; rs470542; rs2051344; rs636692; rs470903; rs509620; rs470498; rs470970; rs470144; rs1789134; rs2282566; rs642506; rs647963; rs470131; rs470907; rs8094821; rs470934; rs470881; rs11150992; rs574099; rs7235695; rs1789085; rs558747; rs2000811; rs736421; rs8093926; rs470967; rs470559; rs1145361; rs3900176; rs2008323; rs8089096; rs470895; rs1622577; rs470866; rs4890791; rs7231830; rs8086634; rs8091710; rs7241461; rs2974260; rs8092433; rs507097; rs470293; rs11874114; rs3794846; rs9675994; rs2008547; rs470291; rs8094289; rs8090356; rs1789137; rs650801; rs2282574; rs6565927; rs523243; rs9964845; rs8090463; rs3794854; rs1789135; rs470318; rs9676140; rs2013963; rs1145360; rs470798; rs470578; rs898229; rs4890893; rs470276; rs584089; rs716458; rs966782; rs470793; rs11150994; rs1026520; rs470468; rs7233242; rs7241373; rs1026521; rs7234883; rs8095585; rs4890883; rs3752070; rs617024; rs3794830; rs470261; rs6565928; rs559418; rs470330; rs11662430; rs3794845; rs9954182; rs470681; rs11661533; rs9676181; rs3934445; rs2282575; rs7236892; rs1674716; rs475841; rs1539991; rs12955019; rs3934443; rs470340; rs11664952; rs475791; rs470508; rs3794835; rs12456480; rs17576751; rs11662391; rs9962038; rs3861306; rs470349; rs470549; rs1674724; rs3794848; rs4890890; rs1612497; rs4890873; rs2122450; rs470924; rs12456341; rs470480; rs470670; rs896038; rs12955250; rs1789083; rs12456475; rs8094060; rs470695; rs1674725; rs3794832; rs3829619; rs2597295; rs4890882; rs1667911; rs12604476; rs1667914; rs4890876; rs1145359; rs3829621; rs721287; rs12964484; rs7407368; rs10514234; rs470664; rs1246874; rs2597296; rs4890888; rs8088304; rs7232929; rs3934444; rs595997; rs8090467; rs3794842; rs4890875; rs3794836; rs9676113; rs11661755; rs2290824; rs12607027; rs8090438; rs7239582; rs1674715; rs898227; rs3794834; rs9959822; rs2974261; rs11661054; rs556751; rs10439001; rs4890891; rs555827; rs921336; rs11663697; rs1674719; rs8084674; rs1145362; rs2282571; rs12956305; rs3934446; rs948880; rs11876196; rs9958028; rs3829620; rs1246603; rs4890877; rs470929; rs3794829; rs510527; rs1026519; rs506323; rs470190; rs12967023; rs2597294; rs3752068; rs871673; rs11875151; rs7239141; rs12454790; rs559292; rs9964602; rs2974262; rs3794837; rs2060649; rs17660901; rs8090564; rs470769; rs4890788; rs9949587; rs17060237; rs17060249; rs2290825; rs11663770; rs17060251; rs9949636; rs8099667; rs3829623; rs7407423; rs9807514; rs470478; rs9949607; rs12608398; rs921337; rs3794851; rs10469072; rs2282573; rs13381497; rs4890786; rs11151001; rs11663325; rs3794843; rs11663742; rs8094626; rs8099008; rs11150998; rs1789131; rs12456024; rs7243285; rs2282572; rs2282570; rs12458393; rs1246872; rs470533; rs12607797; rs2974263; rs7233979; rs7233574; rs11663170; rs1246604; rs12968222; rs580635; rs6565925; rs629945; rs4890790; rs12959623; rs3794839; rs470577; rs1667918; rs11664872; rs9961315; rs7233524; rs7237128; rs12604625; rs11151000; rs12458282; rs8090465; rs8094402; rs11150997; rs10782015; rs8091801; rs1246873; rs8099782; rs8095130; rs8097284; rs1246602; rs1261920; rs1667916; rs8090930; rs470640; rs3829622; rs4890787; rs7231675; rs8090772; rs11876149; rs7234544; rs17060250; rs4890887; rs7232525; rs479114; rs1667910; rs7505230; rs8098769; rs470238; rs520047; rs8088143; rs7227084; rs570389; rs7242698; rs11662063; rs7232346; rs11659352; rs4890785; rs751361; rs12456333; rs17060192; rs470584; rs11151002; rs12959904; rs4890795; rs7228426; rs1268934; rs12967352; rs470479; rs3794840; rs7233072; rs470453; rs2156496; rs470186; rs3813079; rs9952064; rs12454943; rs17576996; rs8096433; rs470252; rs512343; rs10221416; rs7241533; rs1246605; rs13381108; rs7239250; rs470551; rs9945622; rs11660885; rs2290826; rs8097277; rs12958866; rs1246601; rs7237284; rs557659; rs685975; rs7238650; rs7231932; rs1789084; rs3794852; rs12960478; rs3794847; rs3794838; rs581552; rs11664836; rs12456380; rs559399; rs11660979; rs470212; rs12962017; rs7234903; rs10153418; rs4890878; rs470567; rs17060297; rs11150996; rs470335; rs470493; rs6565923; rs2276277; rs1789094; rs470319; rs4890901; rs9966986; rs2276276; rs10221343; rs1048688; rs11559012; rs34545130; rs34435038; rs36036469; rs1893710; rs11559009; rs35499437; rs2897506; rs13381530; rs2897504; rs35358094; rs5024153; rs33966437; rs5826495; rs11331748; rs1584579; rs35523743; rs34095806; rs1977969; rs36171082; rs10454722; rs35925062; rs34454490; rs12955050; rs35923807; rs34753010; rs36073460; rs12605430; rs34783785; rs34678081; rs12962477; rs35136851; rs35135189; rs11359542; rs11293166; rs2406725; rs9952768; rs5826496; rs10713423; rs34309442; rs6146398; rs4494640; rs1667906; rs34330273; rs34008680; rs4890899; rs2897505; rs2897507; rs35106585; rs34930920; rs12957636; rs12956652; rs1059474; rs7964; rs1625042; rs36172305; rs8093312; rs34246877; rs34308071; rs35453944; rs10682890; rs1667907; rs8088587; rs35240388; rs12956648; rs35692920; rs11370299; rs9964017; rs9966152; rs35560093; rs11876582; rs36078757; rs3838892; rs28593671; rs12604394; rs11331749; rs1789076; rs12958854; rs7234131; rs34142608; rs12958875; rs12326360; rs1625095; rs9959030; rs3056846; rs12962471; rs1375968; rs34716646; rs12607023; rs34660063; rs35914059; rs28471065; rs28474795; rs35537892; rs517525; rs8093194; rs34161355; rs4890898; rs12958314; rs35530947; rs11359541; rs36022168; rs508028; rs34698233; rs1622189; rs1789078; rs1667919; rs35957303; rs34863406; rs11338824; rs28384331; rs36230198; rs35043317; rs9944542; rs35066411; rs5826492; rs539926; rs7234396; rs3943395; rs34236204; rs34392069; rs35688328; rs28455004; rs3214873; rs12969118; rs36038482; rs2850209; rs34098362; rs35490623; rs34705439; rs2122449; rs35525905; rs12455658; rs36096666; rs12953724; rs11370657; rs35789059; rs35575050; rs4890889; rs35706956; rs504433; rs2923070; rs12954656; rs35721326; rs1269742; rs35437082; rs34825980; rs35768267; rs898228; rs5826488; rs35938490; rs9961421; rs34982848; rs33983406; rs34914518; rs1046930; rs12456666; rs5826494; rs35204432; rs35870819; rs12458733; rs12960582; rs34088194; rs7505207; rs2974264; rs538222; rs34447266; rs1789128; rs1667949; rs11660481; rs539929; rs12959308; rs12326491; rs4890880; rs34928057; rs470893; rs35090226; rs8083865; rs11298729; rs35905017; rs12970079; rs28523669; rs8090485; rs13381841; rs12970202; rs34179301; rs1667913; rs35778536; rs10613302; rs3056785; rs33971375; rs34325356; rs1269761; rs12454221; rs11367089; rs35417333; rs35687559; rs470921; rs11455414; rs28509179; rs9944893; rs8084038; rs3214874; rs692894; rs8083996; rs8086213; rs35726542; rs34908275; rs470443; rs11402968; rs28360810; rs36105123; rs1789122; rs1247188; rs34685116; rs35111199; rs7236625; rs11150999; rs28590173; rs12955289; rs28665744; rs1271961; rs28558631; rs486033; rs12961856; rs3838890; rs3897650; rs12327285; rs35033872; rs2923074; rs35122022; rs35400049; rs34142646; rs12327217; rs5826493; rs12969206; rs1789141; rs12970402; rs11432792; rs35510052; rs589012; rs12454195; rs10645727; rs36122723; rs5826490; rs34266248; rs12958275; rs12455703; rs4890789; rs34205845; rs2406710; rs35796733; rs2897498; rs28481404; rs28609066; rs12969724; rs35011710; rs28561083; rs12969037; rs35635526; rs11150993; rs10670800; rs12605476; rs12968671; rs11370656; rs3056784; rs11457639; rs2923072; rs34473421; rs10532700; rs34988017; rs28454850; rs35642343; rs3017501; rs11877231; rs3897649; rs34154093; rs28729533; rs28776780; rs34738737; rs12454163; rs11661965; rs35106465; rs9954479; rs35510843; rs28567439; rs34915667; rs35341754; rs10556310; rs35177629; rs1667912; rs527722; rs35582225; rs6650701; rs10567845; rs34397715; rs34462513; rs1055757; rs34768183; rs12959886; rs1789253; rs1674723; rs12456274; rs35417866; rs617969; rs606777; rs12965696; rs34070985; rs2850208; rs1789129; rs35520696; rs34965445; rs34555682; rs1667948; rs12957833; rs1261909; rs3794850; rs35493282; rs7231677; rs3056773; rs5021489; rs4527105; rs12953573; rs34723130; rs470367; rs35192115; rs36017394; rs12953638; rs7236014; rs34945822; rs10556309; rs470980; rs35099759; rs475324; rs583949; rs34544199; rs8091396; rs12454264; rs11422817; rs1674721; rs12956572; rs470917; rs28879124; rs28661612; rs28488290; rs12955776; rs11872487; rs11273645; rs1046931; rs34829403; rs519582; rs34530190; rs3794849; rs10654101; rs35854660; rs1667909; rs10554697; rs558450; rs35099294; rs12457312; rs28415261; rs35321171; rs12970404; rs34879896; rs33932270; rs12953723; rs12956404; rs1789142; rs9959483; rs12956948; rs9951345; rs35591984; rs8083864; rs10526394; rs3838891; rs35068332; rs598348; rs35884498; rs7232640; rs11436164; rs12607641; rs36047934; rs7228598; rs1789130; rs34529087; rs33929749; rs35071014; rs1789254; rs5826489; rs11663912; rs1247187; rs34473725; rs12953684; rs28815543; rs34568117; rs9319655; rs10644482; rs12955437; rs10656491; rs1674722; rs11363307; rs11321875; rs11397672; rs34630649; rs1667917; rs12953712; rs470685; rs35438841; rs36038543; rs10469088; rs1667915; rs35568206; rs35710301; rs4890879; rs2923073; rs28424014; rs11305404; rs33957999; rs34160746; rs7226491; rs9960721; rs7504502; rs35983546; rs35229872; rs12456295; rs7237258; rs1789136; rs664122; rs9957016; rs34623569; rs34009398; rs470505; rs12960504; rs13381797; rs7242091; rs645714; rs4890886; rs611551; rs563901; rs35173653; rs1789127; rs3842671; rs34387671; rs33913578; rs8085851; rs33974021; rs28549273; rs9952636; rs34430892; rs3056884; rs36069074; rs34518416; rs10163866; rs10667203; rs11446871; rs2897508; rs10577153; rs28760550; rs9954826; rs35190126; rs33940322; rs28555591; rs2406729; rs28497522; rs9965258; rs1044088; rs11875409; rs12326156; rs12455522; rs12966573; rs12967593; rs1617137; rs1667901; rs1667903; rs1667957; rs17060488; rs17060490; rs17061722; rs17587448; rs17841728; rs1789118; rs1789119; rs1789121; rs1789256; rs2013313; rs35305608; rs470615; rs470683; rs4890902; rs4890903; rs721286; rs7236465; rs8097016; rs896035; rs896036; rs896040; rs896041; rs948884; rs9944908; rs9955987; rs9958654; rs9961194; rs9966022

# Macromolecular_Interacting_Partner_5_General_References:
4108501; 2427738; 2425357; 2442403; 2472816; 7504278; 1689270; 2426402; 2466844; 7574672; 6201481; 4099924; 7685161; 5128665; 7544282; 9020143

# Macromolecular_Interacting_Partner_5_References:
1372178; 2421004; 2480186; 6165009

# Macromolecular_Interacting_Partner_6_ID:
7201

# Macromolecular_Interacting_Partner_6_Name:
von Willebrand factor precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
vWF[Contains: von Willebrand antigen 2; von Willebrand antigen II]

# Macromolecular_Interacting_Partner_6_Gene_Name:
VWF

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>von Willebrand factor precursor
MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYL
LAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYL
ETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPL
VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGME
YRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPG
TSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQD
HSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDIQLPLLKGDL
RIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG
LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVS
PLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQ
CGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPED
IFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADN
LRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGE
TVKIGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGS
NPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGR
YIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVD
FGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPY
LDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY
ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCE
VAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVE
DISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE
YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRI
ALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVL
SSVDELEQQRDEIVSYLCDLAPEAPPPTLPPHMAQVTVGPGLLGVSTLGPKRNSMVLDVA
FVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGD
ILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLP
GDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTL
SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT
IDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILV
TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM
VTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCD
RGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNK
EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEV
NVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRD
GTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFY
AICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHC
DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQI
CTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHC
ERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVN
STVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAV
MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ
WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERME
ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGEC
CGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHK
CLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMY
SIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
2813

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
309301

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.21

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  extracellular matrix
Component:  extracellular matrix (sensu Metazoa)

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF08742:DUF1787;
PF01826:TIL;
PF00092:VWA;
PF00093:VWC;
PF00094:VWD

# Macromolecular_Interacting_Partner_6_Signals:
1-22

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
37947

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
VWF_HUMAN (P04275)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
VWF

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
VWF

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:12726

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein. Note=Localized to storage granules

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>8442 bp
ATGATTCCTGCCAGATTTGCCGGGGTGCTGCTTGCTCTGGCCCTCATTTTGCCAGGGACC
CTTTGTGCAGAAGGAACTCGCGGCAGGTCATCCACGGCCCGATGCAGCCTTTTCGGAAGT
GACTTCGTCAACACCTTTGATGGGAGCATGTACAGCTTTGCGGGATACTGCAGTTACCTC
CTGGCAGGGGGCTGCCAGAAACGCTCCTTCTCGATTATTGGGGACTTCCAGAATGGCAAG
AGAGTGAGCCTCTCCGTGTATCTTGGGGAATTTTTTGACATCCATTTGTTTGTCAATGGT
ACCGTGACACAGGGGGACCAAAGAGTCTCCATGCCCTATGCCTCCAAAGGGCTGTATCTA
GAAACTGAGGCTGGGTACTACAAGCTGTCCGGTGAGGCCTATGGCTTTGTGGCCAGGATC
GATGGCAGCGGCAACTTTCAAGTCCTGCTGTCAGACAGATACTTCAACAAGACCTGCGGG
CTGTGTGGCAACTTTAACATCTTTGCTGAAGATGACTTTATGACCCAAGAAGGGACCTTG
ACCTCGGACCCTTATGACTTTGCCAACTCATGGGCTCTGAGCAGTGGAGAACAGTGGTGT
GAACGGGCATCTCCTCCCAGCAGCTCATGCAACATCTCCTCTGGGGAAATGCAGAAGGGC
CTGTGGGAGCAGTGCCAGCTTCTGAAGAGCACCTCGGTGTTTGCCCGCTGCCACCCTCTG
GTGGACCCCGAGCCTTTTGTGGCCCTGTGTGAGAAGACTTTGTGTGAGTGTGCTGGGGGG
CTGGAGTGCGCCTGCCCTGCCCTCCTGGAGTACGCCCGGACCTGTGCCCAGGAGGGAATG
GTGCTGTACGGCTGGACCGACCACAGCGCGTGCAGCCCAGTGTGCCCTGCTGGTATGGAG
TATAGGCAGTGTGTGTCCCCTTGCGCCAGGACCTGCCAGAGCCTGCACATCAATGAAATG
TGTCAGGAGCGATGCGTGGATGGCTGCAGCTGCCCTGAGGGACAGCTCCTGGATGAAGGC
CTCTGCGTGGAGAGCACCGAGTGTCCCTGCGTGCATTCCGGAAAGCGCTACCCTCCCGGC
ACCTCCCTCTCTCGAGACTGCAACACCTGCATTTGCCGAAACAGCCAGTGGATCTGCAGC
AATGAAGAATGTCCAGGGGAGTGCCTTGTCACAGGTCAATCACACTTCAAGAGCTTTGAC
AACAGATACTTCACCTTCAGTGGGATCTGCCAGTACCTGCTGGCCCGGGATTGCCAGGAC
CACTCCTTCTCCATTGTCATTGAGACTGTCCAGTGTGCTGATGACCGCGACGCTGTGTGC
ACCCGCTCCGTCACCGTCCGGCTGCCTGGCCTGCACAACAGCCTTGTGAAACTGAAGCAT
GGGGCAGGAGTTGCCATGGATGGCCAGGACGTCCAGCTCCCCCTCCTGAAAGGTGACCTC
CGCATCCAGCATACAGTGACGGCCTCCGTGCGCCTCAGCTACGGGGAGGACCTGCAGATG
GACTGGGATGGCCGCGGGAGGCTGCTGGTGAAGCTGTCCCCCGTCTATGCCGGGAAGACC
TGCGGCCTGTGTGGGAATTACAATGGCAACCAGGGCGACGACTTCCTTACCCCCTCTGGG
CTGGCGGAGCCCCGGGTGGAGGACTTCGGGAACGCCTGGAAGCTGCACGGGGACTGCCAG
GACCTGCAGAAGCAGCACAGCGATCCCTGCGCCCTCAACCCGCGCATGACCAGGTTCTCC
GAGGAGGCGTGCGCGGTCCTGACGTCCCCCACATTCGAGGCCTGCCATCGTGCCGTCAGC
CCGCTGCCCTACCTGCGGAACTGCCGCTACGACGTGTGCTCCTGCTCGGACGGCCGCGAG
TGCCTGTGCGGCGCCCTGGCCAGCTATGCCGCGGCCTGCGCGGGGAGAGGCGTGCGCGTC
GCGTGGCGCGAGCCAGGCCGCTGTGAGCTGAACTGCCCGAAAGGCCAGGTGTACCTGCAG
TGCGGGACCCCCTGCAACCTGACCTGCCGCTCTCTCTCTTACCCGGATGAGGAATGCAAT
GAGGCCTGCCTGGAGGGCTGCTTCTGCCCCCCAGGGCTCTACATGGATGAGAGGGGGGAC
TGCGTGCCCAAGGCCCAGTGCCCCTGTTACTATGACGGTGAGATCTTCCAGCCAGAAGAC
ATCTTCTCAGACCATCACACCATGTGCTACTGTGAGGATGGCTTCATGCACTGTACCATG
AGTGGAGTCCCCGGAAGCTTGCTGCCTGACGCTGTCCTCAGCAGTCCCCTGTCTCATCGC
AGCAAAAGGAGCCTATCCTGTCGGCCCCCCATGGTCAAGCTGGTGTGTCCCGCTGACAAC
CTGCGGGCTGAAGGGCTCGAGTGTACCAAAACGTGCCAGAACTATGACCTGGAGTGCATG
AGCATGGGCTGTGTCTCTGGCTGCCTCTGCCCCCCGGGCATGGTCCGGCATGAGAACAGA
TGTGTGGCCCTGGAAAGGTGTCCCTGCTTCCATCAGGGCAAGGAGTATGCCCCTGGAGAA
ACAGTGAAGATTGGCTGCAACACTTGTGTCTGTCGGGACCGGAAGTGGAACTGCACAGAC
CATGTGTGTGATGCCACGTGCTCCACGATCGGCATGGCCCACTACCTCACCTTCGACGGG
CTCAAATACCTGTTCCCCGGGGAGTGCCAGTACGTTCTGGTGCAGGATTACTGCGGCAGT
AACCCTGGGACCTTTCGGATCCTAGTGGGGAATAAGGGATGCAGCCACCCCTCAGTGAAA
TGCAAGAAACGGGTCACCATCCTGGTGGAGGGAGGAGAGATTGAGCTGTTTGACGGGGAG
GTGAATGTGAAGAGGCCCATGAAGGATGAGACTCACTTTGAGGTGGTGGAGTCTGGCCGG
TACATCATTCTGCTGCTGGGCAAAGCCCTCTCCGTGGTCTGGGACCGCCACCTGAGCATC
TCCGTGGTCCTGAAGCAGACATACCAGGAGAAAGTGTGTGGCCTGTGTGGGAATTTTGAT
GGCATCCAGAACAATGACCTCACCAGCAGCAACCTCCAAGTGGAGGAAGACCCTGTGGAC
TTTGGGAACTCCTGGAAAGTGAGCTCGCAGTGTGCTGACACCAGAAAAGTGCCTCTGGAC
TCATCCCCTGCCACCTGCCATAACAACATCATGAAGCAGACGATGGTGGATTCCTCCTGT
AGAATCCTTACCAGTGACGTCTTCCAGGACTGCAACAAGCTGGTGGACCCCGAGCCATAT
CTGGATGTCTGCATTTACGACACCTGCTCCTGTGAGTCCATTGGGGACTGCGCCTGCTTC
TGCGACACCATTGCTGCCTATGCCCACGTGTGTGCCCAGCATGGCAAGGTGGTGACCTGG
AGGACGGCCACATTGTGCCCCCAGAGCTGCGAGGAGAGGAATCTCCGGGAGAACGGGTAT
GAGTGTGAGTGGCGCTATAACAGCTGTGCACCTGCCTGTCAAGTCACGTGTCAGCACCCT
GAGCCACTGGCCTGCCCTGTGCAGTGTGTGGAGGGCTGCCATGCCCACTGCCCTCCAGGG
AAAATCCTGGATGAGCTTTTGCAGACCTGCGTTGACCCTGAAGACTGTCCAGTGTGTGAG
GTGGCTGGCCGGCGTTTTGCCTCAGGAAAGAAAGTCACCTTGAATCCCAGTGACCCTGAG
CACTGCCAGATTTGCCACTGTGATGTTGTCAACCTCACCTGTGAAGCCTGCCAGGAGCCG
GGAGGCCTGGTGGTGCCTCCCACAGATGCCCCGGTGAGCCCCACCACTCTGTATGTGGAG
GACATCTCGGAACCGCCGTTGCACGATTTCTACTGCAGCAGGCTACTGGACCTGGTCTTC
CTGCTGGATGGCTCCTCCAGGCTGTCCGAGGCTGAGTTTGAAGTGCTGAAGGCCTTTGTG
GTGGACATGATGGAGCGGCTGCGCATCTCCCAGAAGTGGGTCCGCGTGGCCGTGGTGGAG
TACCACGACGGCTCCCACGCCTACATCGGGCTCAAGGACCGGAAGCGACCGTCAGAGCTG
CGGCGCATTGCCAGCCAGGTGAAGTATGCGGGCAGCCAGGTGGCCTCCACCAGCGAGGTC
TTGAAATACACACTGTTCCAAATCTTCAGCAAGATCGACCGCCCTGAAGCCTCCCGCATC
GCCCTGCTCCTGATGGCCAGCCAGGAGCCCCAACGGATGTCCCGGAACTTTGTCCGCTAC
GTCCAGGGCCTGAAGAAGAAGAAGGTCATTGTGATCCCGGTGGGCATTGGGCCCCATGCC
AACCTCAAGCAGATCCGCCTCATCGAGAAGCAGGCCCCTGAGAACAAGGCCTTCGTGCTG
AGCAGTGTGGATGAGCTGGAGCAGCAAAGGGACGAGATCGTTAGCTACCTCTGTGACCTT
GCCCCTGAAGCCCCTCCTCCTACTCTGCCCCCCCACATGGCACAAGTCACTGTGGGCCCG
GGGCTCTTGGGGGTTTCGACCCTGGGGCCCAAGAGGAACTCCATGGTTCTGGATGTGGCG
TTCGTCCTGGAAGGATCGGACAAAATTGGTGAAGCCGACTTCAACAGGAGCAAGGAGTTC
ATGGAGGAGGTGATTCAGCGGATGGATGTGGGCCAGGACAGCATCCACGTCACGGTGCTG
CAGTACTCCTACATGGTGACCGTGGAGTACCCCTTCAGCGAGGCACAGTCCAAAGGGGAC
ATCCTGCAGCGGGTGCGAGAGATCCGCTACCAGGGCGGCAACAGGACCAACACTGGGCTG
GCCCTGCGGTACCTCTCTGACCACAGCTTCTTGGTCAGCCAGGGTGACCGGGAGCAGGCG
CCCAACCTGGTCTACATGGTCACCGGAAATCCTGCCTCTGATGAGATCAAGAGGCTGCCT
GGAGACATCCAGGTGGTGCCCATTGGAGTGGGCCCTAATGCCAACGTGCAGGAGCTGGAG
AGGATTGGCTGGCCCAATGCCCCTATCCTCATCCAGGACTTTGAGACGCTCCCCCGAGAG
GCTCCTGACCTGGTGCTGCAGAGGTGCTGCTCCGGAGAGGGGCTGCAGATCCCCACCCTC
TCCCCTGCACCTGACTGCAGCCAGCCCCTGGACGTGATCCTTCTCCTGGATGGCTCCTCC
AGTTTCCCAGCTTCTTATTTTGATGAAATGAAGAGTTTCGCCAAGGCTTTCATTTCAAAA
GCCAATATAGGGCCTCGTCTCACTCAGGTGTCAGTGCTGCAGTATGGAAGCATCACCACC
ATTGACGTGCCATGGAACGTGGTCCCGGAGAAAGCCCATTTGCTGAGCCTTGTGGACGTC
ATGCAGCGGGAGGGAGGCCCCAGCCAAATCGGGGATGCCTTGGGCTTTGCTGTGCGATAC
TTGACTTCAGAAATGCATGGTGCCAGGCCGGGAGCCTCAAAGGCGGTGGTCATCCTGGTC
ACGGACGTCTCTGTGGATTCAGTGGATGCAGCAGCTGATGCCGCCAGGTCCAACAGAGTG
ACAGTGTTCCCTATTGGAATTGGAGATCGCTACGATGCAGCCCAGCTACGGATCTTGGCA
GGCCCAGCAGGCGACTCCAACGTGGTGAAGCTCCAGCGAATCGAAGACCTCCCTACCATG
GTCACCTTGGGCAATTCCTTCCTCCACAAACTGTGCTCTGGATTTGTTAGGATTTGCATG
GATGAGGATGGGAATGAGAAGAGGCCCGGGGACGTCTGGACCTTGCCAGACCAGTGCCAC
ACCGTGACTTGCCAGCCAGATGGCCAGACCTTGCTGAAGACTCATCGGGTCAACTGTGAC
CGGGGGCTGAGGCCTTCGTGCCCTAACAGCCAGTCCCCTGTTAAAGTGGAAGAGACCTGT
GGCTGCCGCTGGACCTGCCCCTGCGTGTGCACAGGCAGCTCCACTCGGCACATCGTGACC
TTTGATGGGCAGAATTTCAAGCTGACTGGCAGCTGTTCTTATGTCCTATTTCAAAACAAG
GAGCAGGACCTGGAGGTGATTCTCCATAATGGTGCCTGCAGCCCTGGAGCAAGGCAGGGC
TGCATGAAATCCATCGAGGTGAAGCACAGTGCCCTCTCCGTCGAGCTGCACAGTGACATG
GAGGTGACGGTGAATGGGAGACTGGTCTCTGTTCCTTACGTGGGTGGGAACATGGAAGTC
AACGTTTATGGTGCCATCATGCATGAGGTCAGATTCAATCACCTTGGTCACATCTTCACA
TTCACTCCACAAAACAATGAGTTCCAACTGCAGCTCAGCCCCAAGACTTTTGCTTCAAAG
ACGTATGGTCTGTGTGGGATCTGTGATGAGAACGGAGCCAATGACTTCATGCTGAGGGAT
GGCACAGTCACCACAGACTGGAAAACACTTGTTCAGGAATGGACTGTGCAGCGGCCAGGG
CAGACGTGCCAGCCCATCCTGGAGGAGCAGTGTCTTGTCCCCGACAGCTCCCACTGCCAG
GTCCTCCTCTTACCACTGTTTGCTGAATGCCACAAGGTCCTGGCTCCAGCCACATTCTAT
GCCATCTGCCAGCAGGACAGTTGCCACCAGGAGCAAGTGTGTGAGGTGATCGCCTCTTAT
GCCCACCTCTGTCGGACCAACGGGGTCTGCGTTGACTGGAGGACACCTGATTTCTGTGCT
ATGTCATGCCCACCATCTCTGGTCTACAACCACTGTGAGCATGGCTGTCCCCGGCACTGT
GATGGCAACGTGAGCTCCTGTGGGGACCATCCCTCCGAAGGCTGTTTCTGCCCTCCAGAT
AAAGTCATGTTGGAAGGCAGCTGTGTCCCTGAAGAGGCCTGCACTCAGTGCATTGGTGAG
GATGGAGTCCAGCACCAGTTCCTGGAAGCCTGGGTCCCGGACCACCAGCCCTGTCAGATC
TGCACATGCCTCAGCGGGCGGAAGGTCAACTGCACAACGCAGCCCTGCCCCACGGCCAAA
GCTCCCACGTGTGGCCTGTGTGAAGTAGCCCGCCTCCGCCAGAATGCAGACCAGTGCTGC
CCCGAGTATGAGTGTGTGTGTGACCCAGTGAGCTGTGACCTGCCCCCAGTGCCTCACTGT
GAACGTGGCCTCCAGCCCACACTGACCAACCCTGGCGAGTGCAGACCCAACTTCACCTGC
GCCTGCAGGAAGGAGGAGTGCAAAAGAGTGTCCCCACCCTCCTGCCCCCCGCACCGTTTG
CCCACCCTTCGGAAGACCCAGTGCTGTGATGAGTATGAGTGTGCCTGCAACTGTGTCAAC
TCCACAGTGAGCTGTCCCCTTGGGTACTTGGCCTCAACCGCCACCAATGACTGTGGCTGT
ACCACAACCACCTGCCTTCCCGACAAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTG
GGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTG
ATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGC
TTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAG
GTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAG
TGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTC
TTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGC
TTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAG
GCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGC
ACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGG
AAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGT
TGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACA
CTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAG
AGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAG
TGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAG
GAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAG
TCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTAC
TCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAG
CCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAAT
GCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
X04385

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_6_Locus:
12p13.3

# Macromolecular_Interacting_Partner_6_SNPs:
rs1800378; rs1063856; rs216321; rs216311; rs1800385; rs7962217; rs11537643; rs16932374; rs34230288; rs1800387; rs1800383; rs216902; rs216310; rs1800376; rs1063857; rs2228319; rs7312411; rs216867; rs1800375; rs1800384; rs2229444; rs1800380; rs16933969; rs10849371; rs2286608; rs216301; rs216853; rs216328; rs980130; rs216894; rs2239138; rs216889; rs723188; rs216290; rs216313; rs216322; rs216887; rs216309; rs216891; rs2238109; rs216883; rs216896; rs917858; rs1860365; rs216856; rs2109119; rs3782711; rs4764521; rs216331; rs933408; rs216901; rs216318; rs7955850; rs216335; rs216340; rs216329; rs11611917; rs2239156; rs216312; rs216903; rs2058223; rs7133777; rs10849377; rs216809; rs917859; rs4764482; rs11063996; rs216905; rs917857; rs216292; rs11063997; rs7964799; rs2283333; rs723190; rs7969672; rs216893; rs2239157; rs1159993; rs4764478; rs1005251; rs2270152; rs723189; rs7135976; rs2058220; rs216805; rs2286646; rs11609728; rs10849375; rs216872; rs11609696; rs2238103; rs216307; rs2270151; rs3759320; rs3759321; rs12832252; rs11615001; rs216904; rs11063998; rs11614912; rs2239139; rs2239145; rs7968035; rs216873; rs7958883; rs10849378; rs11610629; rs216291; rs980131; rs216320; rs763581; rs11064003; rs2238104; rs216303; rs9645765; rs10466904; rs2239147; rs11608550; rs216811; rs2239140; rs11837434; rs7961844; rs24177; rs216293; rs6489686; rs12829271; rs216306; rs2363309; rs980134; rs7314208; rs216886; rs1860416; rs216323; rs216298; rs216804; rs7954351; rs2270239; rs216295; rs216333; rs1558519; rs216890; rs2239142; rs17491334; rs7967155; rs11064021; rs2070887; rs11836843; rs216802; rs216874; rs2238101; rs216897; rs2058473; rs11612370; rs216860; rs216305; rs3782716; rs12300917; rs16932408; rs1558520; rs216336; rs11833733; rs3213721; rs216338; rs2239159; rs12319392; rs1034933; rs216326; rs7965754; rs11608587; rs216800; rs12099542; rs7308002; rs7136463; rs12307072; rs2058222; rs216880; rs12317523; rs11063955; rs12317079; rs216810; rs11831654; rs6489685; rs7139057; rs2238110; rs11064024; rs177702; rs216302; rs12369177; rs542993; rs2283332; rs11609815; rs1860366; rs2239144; rs11612401; rs2239158; rs11064018; rs7964554; rs216330; rs4764483; rs10774391; rs216332; rs10849362; rs2238112; rs12423243; rs3819537; rs2885752; rs2109118; rs10849385; rs216337; rs12306928; rs216895; rs216300; rs2885749; rs2532859; rs10849380; rs216868; rs11064004; rs1582297; rs216327; rs763580; rs10849361; rs216801; rs216852; rs12368267; rs7965760; rs216304; rs2239162; rs10849376; rs10774387; rs1610055; rs6489691; rs2239154; rs11614545; rs216854; rs11836708; rs216315; rs11063995; rs11831449; rs11613586; rs10849363; rs216898; rs3819541; rs7301070; rs2283331; rs216881; rs4586226; rs216855; rs4764480; rs17419697; rs11063965; rs11608525; rs4764535; rs362255; rs541011; rs216888; rs11829713; rs4764531; rs12831864; rs10849381; rs11063991; rs11064000; rs2236774; rs11063976; rs12297370; rs216314; rs7312746; rs2239137; rs17491320; rs11063956; rs11064033; rs216308; rs10849365; rs2239150; rs7955254; rs10849360; rs11608523; rs11063954; rs11063999; rs2239161; rs3819540; rs2238102; rs1860367; rs2239149; rs11064005; rs10849383; rs4764536; rs7314094; rs10849367; rs1990491; rs10774389; rs216806; rs12366887; rs12368045; rs216297; rs6489693; rs7979264; rs216858; rs11063958; rs3819538; rs11063977; rs10744696; rs11063962; rs2238105; rs7964013; rs2885753; rs11063974; rs1579229; rs216865; rs7315478; rs216884; rs188616; rs7303727; rs6489692; rs7305616; rs7313679; rs7315124; rs769080; rs2239152; rs3765645; rs216316; rs10774388; rs11835809; rs2013307; rs12367254; rs11829469; rs7970924; rs7298566; rs10849369; rs11064019; rs12368446; rs669667; rs2283335; rs216299; rs12423482; rs7301911; rs216870; rs11615036; rs11614772; rs11611805; rs216882; rs2012829; rs12304995; rs216892; rs11829972; rs170048; rs2286937; rs216325; rs11608666; rs526881; rs11064008; rs11063990; rs11614724; rs11063964; rs7956179; rs11615182; rs12307883; rs12829220; rs2109122; rs7314380; rs11613839; rs541012; rs2362483; rs10849364; rs11832009; rs526861; rs1814249; rs11612384; rs12366600; rs12297442; rs12366917; rs216877; rs28365811; rs7980758; rs7976222; rs13377953; rs2239141; rs11063961; rs216294; rs11064029; rs4764532; rs7133457; rs216334; rs28455627; rs12319292; rs216878; rs10849370; rs7298568; rs11835829; rs7306354; rs11615208; rs980133; rs12315477; rs7957672; rs10849379; rs7980753; rs2854866; rs216319; rs216866; rs10849382; rs11064020; rs12305676; rs2191161; rs216803; rs11610548; rs7305522; rs2363329; rs962613; rs1610056; rs12319598; rs4348960; rs11836182; rs11063957; rs7953373; rs216861; rs216857; rs3782715; rs11830385; rs2238106; rs2239155; rs917569; rs11829480; rs10849374; rs11063953; rs2236773; rs7133854; rs4764534; rs2283330; rs11611549; rs7136872; rs2239146; rs11611899; rs2239160; rs2070886; rs7306706; rs7135258; rs12579603; rs10849368; rs7135039; rs4408361; rs11613674; rs1814250; rs12810426; rs183356; rs1860415; rs3741906; rs917568; rs11063959; rs216885; rs216871; rs2005829; rs11064010; rs4764527; rs216339; rs12307110; rs7309514; rs2239148; rs7961290; rs11064014; rs16932406; rs1990318; rs216808; rs12427346; rs190055; rs11064025; rs9634155; rs2239153; rs7961998; rs12367255; rs11616181; rs11063971; rs10849366; rs216317; rs7968888; rs12310690; rs2286938; rs216296; rs499648; rs4764533; rs12371825; rs2362482; rs216879; rs10437830; rs1860364; rs11064031; rs2239143; rs17491418; rs11063981; rs11611919; rs2239151; rs7975429; rs11064022; rs2070883; rs11614723; rs3887143; rs216812; rs7976955; rs1990326; rs10849358; rs7964777; rs7965413; rs7966230; rs7954855; rs35335161; rs5020485; rs33978901; rs11063988; rs1800386; rs1800377; rs35879738; rs11063987; rs34120165; rs11064002; rs11837584; rs11064012; rs41276738; rs2229448; rs35365059; rs1800381; rs41276736; rs11537642; rs34510401; rs35302737; rs4021576; rs35191786; rs34237676; rs41276732; rs16932285; rs3741908; rs3087517; rs2363337; rs10656576; rs35414262; rs10577899; rs11064015; rs35881119; rs12826055; rs4021577; rs7485251; rs5796203; rs7137165; rs12307335; rs4021567; rs811626; rs3782713; rs2854869; rs980132; rs12311371; rs11063960; rs16932350; rs35309907; rs28853276; rs1092092; rs16932345; rs34433330; rs28440903; rs10579907; rs34800208; rs2363331; rs4021585; rs4485164; rs4021579; rs216875; rs28532342; rs34777802; rs35842350; rs35807919; rs4021583; rs5796201; rs12302827; rs34479155; rs11063952; rs4764528; rs7308549; rs7961539; rs2363318; rs11064023; rs35398077; rs11064013; rs2238111; rs11615660; rs11534812; rs35115059; rs2070885; rs3062519; rs28630679; rs34253435; rs11838266; rs28365810; rs41299142; rs35701639; rs10532498; rs34814252; rs2363324; rs887313; rs34536486; rs36007563; rs34789291; rs2058221; rs34927887; rs216864; rs4491293; rs35194208; rs2854870; rs12313683; rs35434595; rs4021561; rs11267365; rs11390977; rs35950632; rs1092458; rs4021581; rs7295164; rs4995110; rs35265805; rs34518634; rs7957068; rs216859; rs10612315; rs495993; rs35073786; rs34082724; rs34337426; rs11386491; rs2363327; rs5796198; rs34115770; rs35136562; rs34977515; rs41405848; rs12310306; rs7961414; rs41276734; rs28369596; rs11064030; rs1088313; rs4021589; rs2363322; rs41320652; rs7306992; rs35426627; rs1091316; rs34260060; rs3819539; rs4021590; rs28464116; rs4021580; rs11064028; rs12301865; rs2537900; rs10609189; rs5796207; rs5796200; rs11063968; rs4021575; rs34584762; rs34791317; rs34933632; rs11614846; rs7955037; rs7398722; rs216862; rs11830320; rs2363334; rs34219825; rs11282431; rs34653249; rs3782714; rs11829058; rs34741728; rs36067650; rs3216178; rs3952284; rs35124526; rs2854867; rs11349246; rs12311305; rs2363319; rs7960061; rs28393881; rs35240575; rs808842; rs11064032; rs10466914; rs2363320; rs4021562; rs2238107; rs34823799; rs11064011; rs216869; rs4021573; rs2363330; rs12299946; rs35465198; rs5796205; rs11451166; rs10650518; rs12826868; rs11063982; rs1088312; rs34238471; rs35399776; rs11063972; rs5796202; rs11281788; rs7485252; rs216813; rs28668954; rs4021587; rs28453687; rs35992766; rs216899; rs7294888; rs35065931; rs34715921; rs12308867; rs11063966; rs3855635; rs34000420; rs10626383; rs4021578; rs12229676; rs7969518; rs12302625; rs34953346; rs11064001; rs3841765; rs35092951; rs34668268; rs7137497; rs11063992; rs4021565; rs34654480; rs10559016; rs35402978; rs2363326; rs4021586; rs216863; rs4460858; rs4021571; rs12827149; rs35551203; rs2363332; rs28758444; rs34404369; rs2159367; rs7295375; rs4021564; rs11429073; rs11063986; rs3062521; rs34547698; rs3062550; rs7138256; rs2192205; rs12297467; rs35926634; rs35928031; rs11063970; rs10577898; rs7397354; rs10667514; rs3952285; rs5796206; rs2363323; rs12315340; rs34507028; rs34386173; rs36100099; rs2070884; rs34071955; rs34277620; rs11268064; rs3782712; rs811625; rs11063963; rs7300389; rs12369181; rs4021584; rs11064027; rs6489694; rs35685925; rs11272545; rs2854871; rs4021574; rs11614865; rs1091315; rs5796209; rs2363333; rs1014389; rs216876; rs11064009; rs35815182; rs11063978; rs3835346; rs34683816; rs11313234; rs10535241; rs34422091; rs11277921; rs7307604; rs3952283; rs34748107; rs41402545; rs11063975; rs11616023; rs11063994; rs216900; rs34781501; rs4021582; rs34791860; rs12146791; rs11613273; rs12578406; rs11064016; rs34737437; rs7485058; rs4021569; rs35395014; rs3837511; rs5796204; rs35649118; rs5796199; rs11367712; rs4764537; rs12309308; rs7965698; rs2191160; rs12827774; rs34140032; rs2854868; rs34444862; rs11064034; rs216851; rs7980045; rs35311176; rs7131844; rs12368821; rs12810526; rs41276742; rs34877178; rs216814; rs12811229; rs11063993; rs216324; rs11063969; rs35802767; rs34989239; rs35473417; rs3062626; rs4008536; rs10622288; rs10219599; rs12813828; rs35829863; rs4495941; rs10459136; rs34998513; rs11063973; rs34635540; rs35254301; rs34170963; rs2363321; rs12819922; rs2363328; rs4764479; rs35972283; rs5796208; rs12099866; rs35040508; rs35122657; rs4021563; rs2159365; rs4021588; rs41388848; rs35671535; rs36077772; rs4021572; rs28504205; rs10532499; rs41276740; rs34443871; rs9989051; rs216807; rs7135169; rs12307884; rs1833134; rs11063967; rs34870498; rs34015284; rs34711844; rs2363325; rs10657127; rs797612; rs34880765; rs34871897; rs11609998; rs3841766; rs7138396; rs34883360; rs35727526; rs11064017; rs35426337; rs808841; rs34220049; rs28365812; rs12826041; rs10656544; rs34951813; rs12302573; rs11615632; rs10532497; rs1610057; rs12227091; rs809514; rs7964010; rs2238108; rs4021570; rs10622633; rs34637418; rs11064007; rs3858686; rs28369235; rs35295594; rs1088314; rs11611247; rs10466903; rs6144598; rs41496447; rs12311643; rs11397409; rs34794268; rs7979300; rs36115023; rs10667650; rs2839721; rs35501232; rs12830421; rs7965425; rs12315619; rs34201373; rs35679344; rs34575095; rs35230054; rs34625593; rs10774394; rs10774398; rs10849387; rs10849391; rs11063943; rs11063944; rs11063945; rs11063951; rs12367467; rs12422307; rs12580835; rs2362481; rs2885517; rs3809241; rs3809242; rs6416321; rs7314566; rs7956269; rs7956772; rs7960314; rs7963244

# Macromolecular_Interacting_Partner_6_General_References:
3489923; 2584182; 3019665; 2828057; 3495266; 3524673; 2864688; 12665801; 3488076; 1988024; 3874428; 3873280; 3875078; 3496594; 10961880; 3502076; 3089784; 9553097; 9331419; 9312128; 12871266; 2786201; 1673047; 1832934; 1761120; 2010538; 1672694; 2011604; 1906179; 1729889; 1420817; 1419803; 1419804; 1429668; 1409710; 8338947; 8435341; 8348943; 8376405; 8486782; 8123843; 8123844; 8088787; 7989040; 8011991; 7620154; 7734373; 8547152; 7789955; 8622978; 10887119

# Macromolecular_Interacting_Partner_6_References:
10713323; 12871332

# Macromolecular_Interacting_Partner_7_ID:
7577

# Macromolecular_Interacting_Partner_7_Name:
Calcitonin gene-related peptide 1 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Calcitonin gene-related peptide I; CGRP-I; Alpha-type CGRP

# Macromolecular_Interacting_Partner_7_Gene_Name:
CALCA

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Calcitonin generelated peptide 1 precursor
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
128

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
13899

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00214:Calc_CGRP_IAPP

# Macromolecular_Interacting_Partner_7_Signals:
1-25

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
179828

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
CALCA_HUMAN (P06881)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
CALCA

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
CALCA

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1437

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>387 bp
ATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCA
GGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCC
ACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAG
ATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAG
AAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGA
TCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGC
AGGCGCCGCAGGGACCTTCAAGCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M12667

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_7_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_7_SNPs:
rs13306224; rs5241; rs5239; rs5240; rs5242; rs2956; rs7110615; rs5237; rs5243; rs2644690; rs35815751; rs5238; rs11607133; rs34901084; rs7925191; rs34294892; rs35212698; rs35909067; rs34815547; rs35731970; rs3758761; rs11023401; rs3781719; rs3781718; rs1553005; rs35365543; rs924099; rs11826691; rs11023400; rs34414857; rs34164367; rs34587547; rs34670162; rs2644689; rs35709504; rs35425520; rs7124346; rs2644687; rs34896084; rs35943755; rs35096144; rs2644688; rs13306223; rs2856867; rs34200140; rs35996804; rs35356387; rs34603621; rs34488736; rs35780811; rs2856866; rs1010042; rs12576047; rs34252928; rs2071411; rs7114837; rs34692826; rs7128563; rs28420578; rs12361439; rs34468174; rs13306225; rs11821926; rs1908683; rs34166188; rs35006116; rs35676062; rs35096190; rs12800646; rs35955129; rs35481990; rs28494031; rs34691228; rs12800297; rs12225355; rs12800139; rs34596504; rs1027425; rs1027426; rs1027427; rs10832338; rs11023403; rs11608134; rs11821055; rs11825513; rs11827349; rs1496163; rs1496166; rs16930769; rs16930770; rs16930784; rs17503142; rs763363; rs7929159; rs7948017; rs903808

# Macromolecular_Interacting_Partner_7_General_References:
3872459; 2571128; 6148938; 2408883; 6610687; 3034287; 6609312; 3492492; 1318039; 1988044; 2039456

# Macromolecular_Interacting_Partner_7_References:
1581336

# Macromolecular_Interacting_Partner_8_ID:
7010

# Macromolecular_Interacting_Partner_8_Name:
Proactivator polypeptide precursor [Contains: Saposin A

# Macromolecular_Interacting_Partner_8_Synonyms:
Protein A; Saposin B-Val; Saposin B; Sphingolipid activator protein 1; SAP-1; Cerebroside sulfate activator; CSAct; Dispersin; Sulfatide/GM1 activator; Saposin C; Co-beta-glucosidase; A1 activator; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2; Saposin D; Protein C; Component C]

# Macromolecular_Interacting_Partner_8_Gene_Name:
PSAP

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Proactivator polypeptide precursor Contains: Saposin 
AMYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVK
SLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILD
IIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLL
YPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMAD
ICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV
EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE
VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL
DRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKI
GACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
524

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
58113

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.82

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular lipid metabolism
Process:  membrane lipid metabolism
Process:  sphingolipid metabolism
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  vacuole
Component:  lytic vacuole
Component:  lysosome

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Saposin D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02199:SapA;
PF05184:SapB_1;
PF03489:SapB_2

# Macromolecular_Interacting_Partner_8_Signals:
1-16

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
220064

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
SAP_HUMAN (P07602)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PSAP

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PSAP

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:9498

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Lysosome

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1584 bp
ATGTACGCCCTCTTCCTCCTGGCCAGCCTCCTGGGCGCGGCTCTAGCCGGCCCGGTCCTT
GGACTGAAAGAATGCACCAGGGGCTCGGCAGTGTGGTGCCAGAATGTGAAGACGGCGTCC
GACTGCGGGGCAGTGAAGCACTGCCTGCAGACCGTTTGGAACAAGCCAACAGTGAAATCC
CTTCCCTGCGACATATGCAAAGACGTTGTCACCGCAGCTGGTGATATGCTGAAGGACAAT
GCCACTGAGGAGGAGATCCTTGTTTACTTGGAGAAGACCTGTGACTGGCTTCCGAAACCG
AACATGTCTGCTTCATGCAAGGAGATAGTGGACTCCTACCTCCCTGTCATCCTGGACATC
ATTAAAGGAGAAATGAGCCGTCCTGGGGAGGTGTGCTCTGCTCTCAACCTCTGCGAGTCT
CTCCAGAAGCACCTAGCAGAGCTGAATCACCAGAAGCAGCTGGAGTCCAATAAGATCCCA
GAGCTGGACATGACTGAGGTGGTGGCCCCCTTCATGGCCAACATCCCTCTCCTCCTCTAC
CCTCAGGACGGCCCCCGCAGCAAGCCCCAGCCAAAGGATAATGGGGACGTTTGCCAGGAC
TGCATTCAGATGGTGACTGACATCCAGACTGCTGTACGGACCAACTCCACCTTTGTCCAG
GCCTTGGTGGAACATGTCAAGGAGGAGTGTGACCGCCTGGGCCCTGGCATGGCCGACATA
TGCAAGAACTATATCAGCCAGTATTCTGAAATTGCTATCCAGATGATGATGCACATGCAG
GATCAGCAACCCAAGGAGATCTGTGCGCTGGTTGGGTTCTGTGATGAGGTGAAAGAGATG
CCCATGCAGACTCTGGTCCCCGCCAAAGTGGCCTCCAAGAATGTCATCCCTGCCCTGGAA
CTGGTGGAGCCCATTAAGAAGCACGAGGTCCCAGCAAAGTCTGATGTTTACTGTGAGGTG
TGTGAATTCCTGGTGAAGGAGGTGACCAAGCTGATTGACAACAACAAGACTGAGAAAGAA
ATACTCGACGCTTTTGACAAAATGTGCTCGAAGCTGCCGAAGTCCCTGTCGGAAGAGTGC
CAGGAGGTGGTGGACACGTACGGCAGCTCCATCCTGTCCATCCTGCTGGAGGAGGTCAGC
CCTGAGCTGGTGTGCAGCATGCTGCACCTCTGCTCTGGCACGCGGCTGCCTGCACTGACC
GTTCACGTGACTCAGCCAAAGGACGGTGGCTTCTGCGAAGTGTGCAAGAAGCTGGTGGGT
TATTTGGATCGCAACCTGGAGAAAAACAGCACCAAGCAGGAGATCCTGGCTGCTCTTGAG
AAAGGCTGCAGCTTCCTGCCAGACCCTTACCAGAAGCAGTGTGATCAGTTTGTGGCAGAG
TACGAGCCCGTGCTGATCGAGATCCTGGTGGAGGTGATGGATCCTTCCTTCGTGTGCTTG
AAAATTGGAGCCTGCCCCTCGGCCCATAAGCCCTTGTTGGGAACTGAGAAGTGTATATGG
GGCCCAAGCTACTGGTGCCAGAACACAGAGACAGCAGCCCAGTGCAATGCTGTCGAGCAT
TGCAAACGCCATGTGTGGAACTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
D00422

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_8_Locus:
10q21-q22

# Macromolecular_Interacting_Partner_8_SNPs:
rs2070188; rs7869; rs1055754; rs2394846; rs762571; rs1015193; rs4237331; rs720295; rs7899959; rs7905774; rs7922255; rs885828; rs4237332; rs4747202; rs4747206; rs2070968; rs2394845; rs4747207; rs1900498; rs7350390; rs728289; rs2394844; rs6480560; rs9663508; rs2593163; rs749823; rs3747860; rs6480561; rs3819341; rs6480559; rs11000017; rs10740391; rs727414; rs2249814; rs2121535; rs7912803; rs2854986; rs7093252; rs10823852; rs3747855; rs11000020; rs16929408; rs11598989; rs11596365; rs4747203; rs12413995; rs10762483; rs4747204; rs4747208; rs11000016; rs12414356; rs2854992; rs11000025; rs727415; rs4747205; rs2166630; rs16913438; rs10762484; rs2854987; rs1900499; rs4454640; rs7917605; rs11000018; rs12413014; rs4746095; rs10762482; rs12415202; rs762573; rs12769743; rs1811087; rs2290023; rs7918049; rs11813373; rs9665661; rs11592448; rs9415055; rs11591470; rs7916568; rs7917015; rs11818931; rs2394843; rs11000019; rs4747209; rs7898293; rs4747210; rs11598617; rs9299509; rs9299510; rs12261323; rs1803650; rs11555015; rs11555016; rs11555021; rs11555017; rs1049882; rs1056711; rs1054851; rs1054293; rs11555018; rs41282246; rs11555020; rs36076120; rs14595; rs1053333; rs12844; rs28365839; rs1803651; rs2121536; rs7090110; rs11596605; rs35320964; rs34332602; rs2593164; rs11000024; rs7091271; rs9416009; rs2854984; rs5786051; rs34551152; rs11415214; rs2593162; rs5786050; rs959189; rs7898921; rs1894270; rs8181334; rs7477139; rs35814383; rs36035697; rs11595017; rs1867981; rs12266725; rs9416010; rs7072424; rs2854990; rs7098225; rs11277133; rs35027678; rs12220614; rs5786049; rs11000023; rs28535035; rs12571681; rs35131935; rs12247334; rs34701833; rs9415054; rs12782637; rs12252719; rs41307569; rs7922360; rs2854989; rs7911004; rs11285654; rs3061818; rs2593161; rs11000026; rs2854985; rs2854991; rs11305283; rs7899796; rs34761785; rs7072021; rs11000021; rs12247599; rs2854988; rs7076038; rs5007340; rs10566090; rs2305203; rs41306532; rs3891337; rs762572; rs5007339; rs10566091; rs2593160; rs3878001; rs35837949; rs7068078; rs35439306; rs12217799; rs35407936; rs34509443; rs35534537; rs2121537; rs35068924; rs11598625; rs34150455; rs28365838; rs7897854; rs34228343; rs10390; rs1054635; rs10762485; rs11000030; rs12252818; rs12416292; rs12774485; rs13377076; rs16929375; rs16929427; rs1867978; rs1992823; rs2290021; rs2290022; rs2394840; rs3802707; rs4746097; rs4747197; rs4747198; rs4747199; rs6480562; rs7085713; rs7092990; rs9415051; rs9415053

# Macromolecular_Interacting_Partner_8_General_References:
2515150; 2498298; 2842863; 1612590; 8323276; 1958198; 2013321; 2717620; 8370464; 2825202; 2868718; 3242555; 2209618; 3442600; 2845979; 3048308; 10562467; 7730378; 11180632; 10406958; 12510003; 10510427; 12518053; 7866401; 2302219; 2320574; 2019586; 2060627

# Macromolecular_Interacting_Partner_8_References:
12126932; 1350885; 2498298; 3048308

# Macromolecular_Interacting_Partner_9_ID:
7614

# Macromolecular_Interacting_Partner_9_Name:
P-selectin precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Granule membrane protein 140; GMP-140; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62P antigen

# Macromolecular_Interacting_Partner_9_Gene_Name:
SELP

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Pselectin precursor
MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYC
QNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTKKALTNEAENWADN
EPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGN
YTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPS
KLECLASGIWTNKPPQCLAAQCPPLKIPERGNMICLHSAKAFQHQSSCSFSCEEGFALVG
PEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRV
RGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGF
MLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNE
GLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFIC
DEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHF
SCNNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGLQCPALTTPGQGTMYCRHHPG
TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL
WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVA
STIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
830

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
90845

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.64

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00008:EGF;
PF00059:Lectin_C;
PF00084:Sushi

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
772-795

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
183389

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
LYAM3_HUMAN (P16109)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SELP

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SELP

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:10721

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2493 bp
ATGGCCAACTGCCAAATAGCCATCTTGTACCAGAGATTCCAGAGAGTGGTCTTTGGAATT
TCCCAACTCCTTTGCTTCAGTGCCCTGATCTCTGAACTAACAAACCAGAAAGAAGTGGCA
GCATGGACTTATCATTACAGCACAAAAGCATACTCATGGAATATTTCCCGTAAATACTGC
CAGAATCGCTACACAGACTTAGTGGCCATCCAGAATAAAAATGAAATTGATTACCTCAAT
AAGGTCCTACCCTACTACAGCTCCTACTACTGGATTGGGATCCGAAAGAACAATAAGACA
TGGACATGGGTGGGAACCAAAAAGGCTCTCACCAACGAGGCTGAGAACTGGGCTGATAAT
GAACCTAACAACAAAAGGAACAACGAGGACTGCGTGGAGATATACATCAAGAGTCCGTCA
GCCCCTGGCAAGTGGAATGATGAGCACTGCTTGAAGAAAAAGCACGCATTGTGTTACACA
GCCTCCTGCCAGGACATGTCCTGCAGCAAACAAGGAGAGTGCCTCGAGACCATCGGGAAC
TACACCTGCTCCTGTTACCCTGGATTCTATGGGCCAGAATGTGAATACGTGAGAGAGTGT
GGAGAACTTGAGCTCCCTCAACACGTGCTCATGAACTGCAGCCACCCTCTGGGAAACTTC
TCTTTTAACTCGCAGTGCAGCTTCCACTGCACTGACGGGTACCAAGTAAATGGGCCCAGC
AAGCTGGAATGCTTGGCTTCTGGAATCTGGACAAATAAGCCTCCACAGTGTTTAGCTGCC
CAGTGCCCACCCCTGAAGATTCCTGAACGAGGAAACATGATCTGCCTTCATTCTGCAAAA
GCATTCCAGCATCAGTCTAGCTGCAGCTTCAGTTGTGAAGAGGGATTTGCATTAGTTGGA
CCGGAAGTGGTGCAATGCACAGCCTCGGGGGTATGGACAGCCCCAGCCCCAGTGTGTAAA
GCTGTGCAGTGTCAGCACCTGGAAGCCCCCAGTGAAGGAACCATGGACTGTGTTCATCCG
CTCACTGCTTTTGCCTATGGCTCCAGCTGCAAATTTGAGTGCCAGCCCGGCTACAGAGTG
AGGGGCTTGGACATGCTCCGCTGCATTGACTCTGGACACTGGTCTGCACCCTTGCCAACC
TGTGAGGCTATTTCGTGTGAGCCGCTGGAGAGTCCTGTCCACGGAAGCATGGATTGCTCT
CCATCCTTGAGAGCGTTTCAGTATGACACCAACTGTAGCTTCCGCTGTGCTGAAGGTTTC
ATGCTGAGAGGAGCCGATATAGTTCGGTGTGATAACTTGGGACAGTGGACAGCACCAGCC
CCAGTCTGTCAAGCTTTGCAGTGCCAGGATCTCCCAGTTCCAAATGAGGCCCGGGTGAAC
TGCTCCCACCCCTTCGGTGCCTTTAGGTACCAGTCAGTCTGCAGCTTCACCTGCAATGAA
GGCTTGCTCCTGGTGGGAGCAAGTGTGCTACAGTGCTTGGCTACTGGAAACTGGAATTCT
GTTCCTCCAGAATGCCAAGCCATTCCCTGCACACCTTTGCTAAGCCCTCAGAATGGAACA
ATGACCTGTGTTCAACCTCTTGGAAGTTCCAGTTATAAATCCACATGTCAATTCATCTGT
GACGAGGGATATTCTTTGTCTGGACCAGAAAGATTGGATTGTACTCGATCGGGACGCTGG
ACAGACTCCCCACCAATGTGTGAAGCCATCAAGTGCCCAGAACTCTTTGCCCCAGAGCAG
GGCAGCCTGGATTGTTCTGACACTCGTGGAGAATTCAATGTTGGCTCCACCTGTCATTTC
TCTTGTAACAATGGCTTTAAGCTGGAGGGGCCCAATAATGTGGAATGCACAACTTCTGGA
AGATGGTCAGCTACTCCACCAACCTGCAAAGGCATAGCATCACTTCCTACTCCAGGGTTG
CAATGTCCAGCCCTCACCACTCCTGGGCAGGGAACCATGTACTGTAGGCATCATCCGGGA
ACCTTTGGTTTTAATACCACTTGTTACTTTGGCTGCAACGCTGGATTCACACTCATAGGA
GACAGCACTCTCAGCTGCAGACCTTCAGGACAATGGACAGCAGTAACTCCAGCATGCAGA
GCTGTGAAATGCTCAGAACTACATGTTAATAAGCCAATAGCGATGAACTGCTCCAACCTC
TGGGGAAACTTCAGTTATGGATCAATCTGCTCTTTCCATTGTCTAGAGGGCCAGTTACTT
AATGGCTCTGCACAAACAGCATGCCAAGAGAATGGCCACTGGTCAACTACCGTGCCAACC
TGCCAAGCAGGACCATTGACTATCCAGGAAGCCCTGACTTACTTTGGTGGAGCGGTGGCT
TCTACAATAGGTCTGATAATGGGTGGGACGCTCCTGGCTTTGCTAAGAAAGCGTTTCAGA
CAAAAAGATGATGGGAAATGCCCCTTGAATCCTCACAGCCACCTAGGAACATATGGAGTT
TTTACAAACGCTGCATTTGACCCGAGTCCTTAA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M60234

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_9_Locus:
1q22-q25

# Macromolecular_Interacting_Partner_9_SNPs:
rs6136; rs2228672; rs3917724; rs6125; rs6127; rs6133; rs3917769; rs6131; rs3917812; rs3917814; rs6130; rs6128; rs3917831; rs12042120; rs6135; rs6132; rs3917805; rs3917813; rs6129; rs3917853; rs3917854; rs3917856; rs3917855; rs3917852; rs2235302; rs2142760; rs2236868; rs2223303; rs742126; rs2244529; rs2235305; rs3917765; rs3917779; rs3917820; rs3917786; rs2236867; rs3917824; rs3917795; rs2205896; rs3917768; rs1569471; rs3917783; rs732314; rs2420378; rs3917688; rs3917679; rs3917843; rs760694; rs3917802; rs3917672; rs3917698; rs3917740; rs3917792; rs3766126; rs742125; rs3917782; rs3917797; rs3917819; rs2205895; rs2076074; rs3917832; rs742127; rs3917788; rs3917770; rs3917687; rs3917826; rs3917691; rs3917703; rs3917751; rs3917711; rs3917707; rs3917793; rs764199; rs3917806; rs3917798; rs3917683; rs3917655; rs3917739; rs3917803; rs3917750; rs3917811; rs3917848; rs3917836; rs3917729; rs3917657; rs2235304; rs3917743; rs3917781; rs3917790; rs3917715; rs2298903; rs3917762; rs3917775; rs3917727; rs3917778; rs3917678; rs3917686; rs3917690; rs3917710; rs3917835; rs3917789; rs3917862; rs3917787; rs3917730; rs3917771; rs3917780; rs3917661; rs3917827; rs3917705; rs3917844; rs3917709; rs3917753; rs3917839; rs3917720; rs3917717; rs3917851; rs2244526; rs2235303; rs3917731; rs3766122; rs3917714; rs1997664; rs17522707; rs3917810; rs3917849; rs3917777; rs3917840; rs2236866; rs3917744; rs10800459; rs3917816; rs3917829; rs3917664; rs3917699; rs3917726; rs3917748; rs3917754; rs3917845; rs3917807; rs3917675; rs3917697; rs3917772; rs3917870; rs3917818; rs3917767; rs3917732; rs3917713; rs3917659; rs3917721; rs3917660; rs3917773; rs3917825; rs3917866; rs3917873; rs3917841; rs3917681; rs3917706; rs3917662; rs12067152; rs3917693; rs1883247; rs3917838; rs3917822; rs3917850; rs3917695; rs3917859; rs3917701; rs3917734; rs2205894; rs3917842; rs3917745; rs3917725; rs3917801; rs3917704; rs3917808; rs3917665; rs3917828; rs3917684; rs3917737; rs3917696; rs3917676; rs3917682; rs3917654; rs3917830; rs3917846; rs3917833; rs3917794; rs3917785; rs3917774; rs3917752; rs3917708; rs13306837; rs3917784; rs3917689; rs3917680; rs3917865; rs3216192; rs3917761; rs3917847; rs3917804; rs3917694; rs3917716; rs3917719; rs3917733; rs3917747; rs3917728; rs3917692; rs3917834; rs2205893; rs3917702; rs3917763; rs3917749; rs3917700; rs3917663; rs3917758; rs3917722; rs1018828; rs1800805; rs1800808; rs3753306; rs742124; rs3917651; rs3917647; rs3917857; rs3917652; rs3917815; rs3917718; rs6134; rs7529463; rs35392020; rs6124; rs3917742; rs3917869; rs35101476; rs6126; rs3917875; rs3917872; rs34136141; rs35706397; rs3981193; rs35459911; rs5778626; rs3917809; rs9787264; rs3917756; rs3917764; rs6660207; rs3917868; rs3917677; rs3917666; rs34459258; rs3917863; rs3917746; rs3917669; rs3917685; rs3917800; rs35824243; rs10603647; rs3917674; rs3035296; rs12746584; rs3917741; rs1569478; rs13306840; rs11388284; rs6663860; rs3917757; rs35332999; rs5778625; rs3216191; rs3917723; rs3917670; rs3917871; rs35975478; rs3917861; rs3917735; rs34262091; rs3917667; rs9970173; rs3917668; rs10697644; rs3917867; rs3917821; rs3917766; rs34328397; rs3917817; rs12741092; rs3981194; rs34478968; rs34013258; rs11424563; rs35999435; rs35303442; rs3917837; rs3886553; rs3917864; rs35889765; rs3917658; rs35043289; rs3917712; rs3917759; rs10919199; rs3830734; rs11423543; rs35481060; rs34089819; rs12022109; rs3917760; rs35956562; rs13306836; rs13306841; rs3917738; rs3917799; rs3917656; rs12144431; rs3917673; rs3917776; rs1569477; rs3917796; rs36114270; rs2298904; rs12760008; rs3917874; rs3917860; rs3917823; rs11364443; rs3917755; rs12742506; rs12144433; rs7532184; rs3917671; rs3917791; rs3917653; rs28503394; rs36058464; rs1800806; rs35257922; rs3917650; rs3917648; rs10489184; rs10489185; rs10800460; rs10919197; rs12025263; rs12091166; rs12401978; rs1569476; rs16862404; rs17523783; rs2205892; rs2269648; rs3753305; rs3917858; rs6028; rs6664922; rs6666554; rs6691334; rs6703865; rs9332479; rs9332480; rs9332482; rs9332483; rs9332484; rs9332485; rs9332486; rs9332487; rs9332488; rs9332491; rs9332492; rs9332493; rs9332494; rs9332496; rs9332498; rs9332499; rs9332502; rs9332504; rs9332679; rs9332682; rs9332684; rs9659257

# Macromolecular_Interacting_Partner_9_General_References:
2466574; 7684381; 11237770; 8901515; 7505680; 9668170; 10391209

# Macromolecular_Interacting_Partner_9_References:
10619362; 10864479; 11479151; 11739312

# Macromolecular_Interacting_Partner_10_ID:
7803

# Macromolecular_Interacting_Partner_10_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_10_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_10_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_10_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_10_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_10_References:
2986554; 43899; 6273571

# Macromolecular_Interacting_Partner_11_ID:
8432

# Macromolecular_Interacting_Partner_11_Name:
Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Com

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
C3

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Complement C3 precursor Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
1663

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
187150

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
 ||
>>>
Process:  humoral immune response
Process:  complement activation
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
Process:  inflammatory response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00207:A2M;
PF07678:A2M_comp;
PF01835:A2M_N;
PF07703:A2M_N_2;
PF07677:A2M_recep;
PF01821:ANATO;
PF01759:NTR

# Macromolecular_Interacting_Partner_11_Signals:
1-22

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
179665

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CO3_HUMAN (P01024)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
C3

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
C3

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:1318

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>4992 bp
ATGGGACCCACCTCAGGTCCCAGCCTGCTGCTCCTGCTACTAACCCACCTCCCCCTGGCT
CTGGGGAGTCCCATGTACTCTATCATCACCCCCAACATCTTGCGGCTGGAGAGCGAGGAG
ACCATGGTGCTGGAGGCCCACGACGCGCAAGGGGATGTTCCAGTCACTGTTACTGTCCAC
GACTTCCCAGGCAAAAAACTAGTGCTGTCCAGTGAGAAGACTGTGCTGACCCCTGCCACC
AACCACATGGGCAACGTCACCTTCACGATCCCAGCCAACAGGGAGTTCAAGTCAGAAAAG
GGGCGCAACAAGTTCGTGACCGTGCAGGCCACCTTCGGGACCCAAGTGGTGGAGAAGGTG
GTGCTGGTCAGCCTGCAGAGCGGGTACCTCTTCATCCAGACAGACAAGACCATCTACACC
CCTGGCTCCACAGTTCTCTATCGGATCTTCACCGTCAACCACAAGCTGCTACCCGTGGGC
CGGACGGTCATGGTCAACATTGAGAACCCGGAAGGCATCCCGGTCAAGCAGGACTCCTTG
TCTTCTCAGAACCAGCTTGGCGTCTTGCCCTTGTCTTGGGACATTCCGGAACTCGTCAAC
ATGGGCCAGTGGAAGATCCGAGCCTACTATGAAAACTCACCACAGCAGGTCTTCTCCACT
GAGTTTGAGGTGAAGGAGTACGTGCTGCCCAGTTTCGAGGTCATAGTGGAGCCTACAGAG
AAATTCTACTACATCTATAACGAGAAGGGCCTGGAGGTCACCATCACCGCCAGGTTCCTC
TACGGGAAGAAAGTGGAGGGAACTGCCTTTGTCATCTTCGGGATCCAGGATGGCGAACAG
AGGATTTCCCTGCCTGAATCCCTCAAGCGCATTCCGATTGAGGATGGCTCGGGGGAGGTT
GTGCTGAGCCGGAAGGTACTGCTGGACGGGGTGCAGAACCTCCGAGCAGAAGACCTGGTG
GGGAAGTCTTTGTACGTGTCTGCCACCGTCATCTTGCACTCAGGCAGTGACATGGTGCAG
GCAGAGCGCAGCGGGATCCCCATCGTGACCTCTCCCTACCAGATCCACTTCACCAAGACA
CCCAAGTACTTCAAACCAGGAATGCCCTTTGACCTCATGGTGTTCGTGACGAACCCTGAT
GGCTCTCCAGCCTACCGAGTCCCCGTGGCAGTCCAGGGCGAGGACACTGTGCAGTCTCTA
ACCCAGGGAGATGGCGTGGCCAAACTCAGCATCAACACACACCCCAGCCAGAAGCCCTTG
AGCATCACGGTGCGCACGAAGAAGCAGGAGCTCTCGGAGGCAGAGCAGGCTACCAGGACC
ATGCAGGCTCTGCCCTACAGCACCGTGGGCAACTCCAACAATTACCTGCATCTCTCAGTG
CTACGTACAGAGCTCAGACCCGGGGAGACCCTCAACGTCAACTTCCTCCTGCGAATGGAC
CGCGCCCACGAGGCCAAGATCCGCTACTACACCTACCTGATCATGAACAAGGGCAGGCTG
TTGAAGGCGGGACGCCAGGTGCGAGAGCCCGGCCAGGACCTGGTGGTGCTGCCCCTGTCC
ATCACCACCGACTTCATCCCTTCCTTCCGCCTGGTGGCGTACTACACGCTGATCGGTGCC
AGCGGCCAGAGGGAGGTGGTGGCCGACTCCGTGTGGGTGGACGTCAAGGACTCCTGCGTG
GGCTCGCTGGTGGTAAAAAGCGGCCAGTCAGAAGACCGGCAGCCTGTACCTGGGCAGCAG
ATGACCCTGAAGATAGAGGGTGACCACGGGGCCCGGGTGGTACTGGTGGCCGTGGACAAG
GGCGTGTTCGTGCTGAATAAGAAGAACAAACTGACGCAGAGTAAGATCTGGGACGTGGTG
GAGAAGGCAGACATCGGCTGCACCCCGGGCAGTGGGAAGGATTACGCCGGTGTCTTCTCC
GACGCAGGGCTGACCTTCACGAGCAGCAGTGGCCAGCAGACCGCCCAGAGGGCAGAACTT
CAGTGCCCGCAGCCAGCCGCCCGCCGACGCCGTTCCGTGCAGCTCACGGAGAAGCGAATG
GACAAAGTCGGCAAGTACCCCAAGGAGCTGCGCAAGTGCTGCGAGGACGGCATGCGGGAG
AACCCCATGAGGTTCTCGTGCCAGCGCCGGACCCGTTTCATCTCCCTGGGCGAGGCGTGC
AAGAAGGTCTTCCTGGACTGCTGCAACTACATCACAGAGCTGCGGCGGCAGCACGCGCGG
GCCAGCCACCTGGGCCTGGCCAGGAGTAACCTGGATGAGGACATCATTGCAGAAGAGAAC
ATCGTTTCCCGAAGTGAGTTCCCAGAGAGCTGGCTGTGGAACGTTGAGGACTTGAAAGAG
CCACCGAAAAATGGAATCTCTACGAAGCTCATGAATATATTTTTGAAAGACTCCATCACC
ACGTGGGAGATTCTGGCTGTCAGCATGTCGGACAAGAAAGGGATCTGTGTGGCAGACCCC
TTCGAGGTCACAGTAATGCAGGACTTCTTCATCGACCTGCGGCTACCCTACTCTGTTGTT
CGAAACGAGCAGGTGGAAATCCGAGCCGTTCTCTACAATTACCGGCAGAACCAAGAGCTC
AAGGTGAGGGTGGAACTACTCCACAATCCAGCCTTCTGCAGCCTGGCCACCACCAAGAGG
CGTCACCAGCAGACCGTAACCATCCCCCCCAAGTCCTCGTTGTCCGTTCCATATGTCATC
GTGCCGCTAAAGACCGGCCTGCAGGAAGTGGAAGTCAAGGCTGCCGTCTACCATCATTTC
ATCAGTGACGGTGTCAGGAAGTCCCTGAAGGTCGTGCCGGAAGGAATCAGAATGAACAAA
ACTGTGGCTGTTCGCACCCTGGATCCAGAACGCCTGGGCCGTGAAGGAGTGCAGAAAGAG
GACATCCCACCTGCAGACCTCAGTGACCAAGTCCCGGACACCGAGTCTGAGACCAGAATT
CTCCTGCAAGGGACCCCAGTGGCCCAGATGACAGAGGATGCCGTCGACGCGGAACGGCTG
AAGCACCTCATTGTGACCCCCTCGGGCTGCGGGGAACAGAACATGATCGGCATGACGCCC
ACGGTCATCGCTGTGCATTACCTGGATGAAACGGAGCAGTGGGAGAAGTTCGGCCTAGAG
AAGCGGCAGGGGGCCTTGGAGCTCATCAAGAAGGGGTACACCCAGCAGCTGGCCTTCAGA
CAACCCAGCTCTGCCTTTGCGGCCTTCGTGAAACGGGCACCCAGCACCTGGCTGACCGCC
TACGTGGTCAAGGTCTTCTCTCTGGCTGTCAACCTCATCGCCATCGACTCCCAAGTCCTC
TGCGGGGCTGTTAAATGGCTGATCCTGGAGAAGCAGAAGCCCGACGGGGTCTTCCAGGAG
GATGCGCCCGTGATACACCAAGAAATGATTGGTGGATTACGGAACAACAACGAGAAAGAC
ATGGCCCTCACGGCCTTTGTTCTCATCTCGCTGCAGGAGGCTAAAGATATTTGCGAGGAG
CAGGTCAACAGCCTGCCAGGCAGCATCACTAAAGCAGGAGACTTCCTTGAAGCCAACTAC
ATGAACCTACAGAGATCCTACACTGTGGCCATTGCTGGCTATGCTCTGGCCCAGATGGGC
AGGCTGAAGGGGCCTCTTCTTAACAAATTTCTGACCACAGCCAAAGATAAGAACCGCTGG
GAGGACCCTGGTAAGCAGCTCTACAACGTGGAGGCCACATCCTATGCCCTCTTGGCCCTA
CTGCAGCTAAAAGACTTTGACTTTGTGCCTCCCGTCGTGCGTTGGCTCAATGAACAGAGA
TACTACGGTGGTGGCTATGGCTCTACCCAGGCCACCTTCATGGTGTTCCAAGCCTTGGCT
CAATACCAAAAGGACGCCCCTGACCACCAGGAACTGAACCTTGATGTGTCCCTCCAACTG
CCCAGCCGCAGCTCCAAGATCACCCACCGTATCCACTGGGAATCTGCCAGCCTCCTGCGA
TCAGAAGAGACCAAGGAAAATGAGGGTTTCACAGTCACAGCTGAAGGAAAAGGCCAAGGC
ACCTTGTCGGTGGTGACAATGTACCATGCTAAGGCCAAAGATCAACTCACCTGTAATAAA
TTCGACCTCAAGGTCACCATAAAACCAGCACCGGAAACAGAAAAGAGGCCTCAGGATGCC
AAGAACACTATGATCCTTGAGATCTGTACCAGGTACCGGGGAGACCAGGATGCCACTATG
TCTATATTGGACATATCCATGATGACTGGCTTTGCTCCAGACACAGATGACCTGAAGCAG
CTGGCCAATGGTGTTGACAGATACATCTCCAAGTATGAGCTGGACAAAGCCTTCTCCGAT
AGGAACACCCTCATCATCTACCTGGACAAGGTCTCACACTCTGAGGATGACTGTCTAGCT
TTCAAAGTTCACCAATACTTTAATGTAGAGCTTATCCAGCCTGGAGCAGTCAAGGTCTAC
GCCTATTACAACCTGGAGGAAAGCTGTACCCGGTTCTACCATCCGGAAAAGGAGGATGGA
AAGCTGAACAAGCTCTGCCGTGATGAACTGTGCCGCTGTGCTGAGGAGAATTGCTTCATA
CAAAAGTCGGATGACAAGGTCACCCTGGAAGAACGGCTGGACAAGGCCTGTGAGCCAGGA
GTGGACTATGTGTACAAGACCCGACTGGTCAAGGTTCAGCTGTCCAATGACTTTGACGAG
TACATCATGGCCATTGAGCAGACCATCAAGTCAGGCTCGGATGAGGTGCAGGTTGGACAG
CAGCGCACGTTCATCAGCCCCATCAAGTGCAGAGAAGCCCTGAAGCTGGAGGAGAAGAAA
CACTACCTCATGTGGGGTCTCTCCTCCGATTTCTGGGGAGAGAAGCCCAACCTCAGCTAC
ATCATCGGGAAGGACACTTGGGTGGAGCACTGGCCTGAGGAGGACGAATGCCAAGACGAA
GAGAACCAGAAACAATGCCAGGACCTCGGCGCCTTCACCGAGAGCATGGTTGTCTTTGGG
TGCCCCAACTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
K02765

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_11_Locus:
19p13.3-p13.2

# Macromolecular_Interacting_Partner_11_SNPs:
rs2230199; rs11569422; rs1047286; rs11569534; rs11569541; rs2230210; rs428453; rs423490; rs344534; rs2230205; rs2230200; rs2230208; rs7951; rs2230204; rs2230203; rs11569453; rs2230201; rs11569535; rs34029609; rs17030; rs11569571; rs339394; rs432001; rs2241392; rs344548; rs1389623; rs6417195; rs344539; rs8107911; rs2253756; rs2277984; rs406514; rs8112351; rs421147; rs451760; rs2287846; rs2287847; rs1895388; rs344550; rs8108377; rs7257062; rs403897; rs438703; rs430507; rs2547438; rs594974; rs2250656; rs344543; rs400443; rs388442; rs436041; rs10402876; rs1389625; rs7258241; rs10410674; rs389404; rs366510; rs11085193; rs2287845; rs11672613; rs2241389; rs344540; rs2241394; rs431543; rs420088; rs435499; rs2642196; rs10406463; rs2270521; rs2355315; rs11569438; rs11569507; rs11569523; rs10221476; rs2642208; rs11569429; rs433594; rs344549; rs344536; rs11569428; rs11569562; rs344538; rs2241390; rs11569536; rs11085196; rs448260; rs3745567; rs344555; rs11085194; rs2355314; rs11569411; rs11569511; rs11569458; rs344542; rs344552; rs10403713; rs11569556; rs11569565; rs445750; rs11085192; rs11085199; rs4807894; rs10411506; rs3745565; rs2642207; rs11569538; rs11569529; rs392690; rs2241391; rs10414623; rs11569457; rs10411974; rs406114; rs2270520; rs11569441; rs11569501; rs408290; rs2241393; rs2547436; rs432823; rs385791; rs11569459; rs344535; rs3215059; rs448488; rs11085195; rs344541; rs237554; rs408114; rs2642209; rs344553; rs344554; rs11569582; rs9710242; rs2277983; rs11569561; rs2287848; rs12609788; rs3745568; rs3745566; rs344545; rs4807895; rs344546; rs451429; rs10853995; rs344537; rs11569514; rs402756; rs11666133; rs11569440; rs11569515; rs11569495; rs11569540; rs11569576; rs11569558; rs11569520; rs11569552; rs405566; rs11569425; rs344551; rs11569436; rs11569508; rs11569497; rs11569517; rs11569545; rs11569510; rs11570240; rs11569414; rs11569400; rs11569542; rs2642203; rs11569519; rs11569500; rs11569474; rs11569499; rs445954; rs11569572; rs11882156; rs189367; rs11569433; rs11569470; rs11569416; rs11569547; rs11569575; rs12609787; rs11569439; rs11569492; rs11569502; rs11570241; rs11569446; rs11570239; rs11569404; rs408004; rs11569413; rs11569494; rs344544; rs11569395; rs11569443; rs11569427; rs11569479; rs11569513; rs11569469; rs11569553; rs11569526; rs11569424; rs11569406; rs11569516; rs11569496; rs11569448; rs11569415; rs2642198; rs344556; rs11569518; rs11569509; rs11569551; rs2355316; rs11569521; rs11569560; rs11569397; rs11569573; rs11570243; rs11569544; rs11569417; rs11569491; rs11569512; rs11569503; rs11569445; rs11569432; rs11569450; rs11569546; rs11569537; rs11085197; rs11569431; rs11569557; rs11569426; rs11569401; rs393770; rs11569419; rs11569410; rs11569487; rs11569442; rs11569468; rs11569505; rs11569466; rs11569555; rs11569449; rs11569584; rs11569471; rs406414; rs11569564; rs11665922; rs163913; rs379527; rs10402399; rs11569393; rs4513211; rs2004270; rs339392; rs11569394; rs339393; rs11569585; rs11569587; rs17626094; rs7508623; rs1803222; rs34370481; rs1803220; rs1803225; rs11569472; rs7256789; rs1803224; rs1803223; rs1803219; rs34116775; rs12981071; rs2547440; rs35537718; rs2642206; rs5826946; rs11569435; rs12971981; rs35162257; rs344547; rs11569532; rs1833792; rs408744; rs11569570; rs11569405; rs2431865; rs12980813; rs11569581; rs2547439; rs34273347; rs11569548; rs35401128; rs11569578; rs11569396; rs182940; rs12981081; rs34769842; rs34081046; rs7248462; rs35743334; rs11569583; rs2277982; rs380819; rs11569398; rs11671205; rs427964; rs34420628; rs11569522; rs34248111; rs11569490; rs10572042; rs36168646; rs11569421; rs2642199; rs11421545; rs10537124; rs35530833; rs3837943; rs34871929; rs35726512; rs36180890; rs2431864; rs36160495; rs7408847; rs11569577; rs11570244; rs7248455; rs11569524; rs36032405; rs8102633; rs5017915; rs2642197; rs35405724; rs10628051; rs11569418; rs11569460; rs34917455; rs11569444; rs5826944; rs2355317; rs36014764; rs11569549; rs11569504; rs11569437; rs11569462; rs11569533; rs35553307; rs11569543; rs1389624; rs11569559; rs11883407; rs35927910; rs12982678; rs11569475; rs11569447; rs1065579; rs11569506; rs11569399; rs12980805; rs12974348; rs11569580; rs11569498; rs427593; rs10415542; rs11569579; rs33986916; rs8102618; rs11569489; rs10596077; rs2642202; rs10408682; rs34173957; rs10526582; rs35584057; rs12983602; rs34193524; rs34804877; rs10715405; rs16993725; rs10664581; rs10659507; rs374750; rs11666563; rs3745558; rs34659937; rs5017914; rs35034584; rs11569574; rs13345176; rs10628052; rs2291665; rs11569434; rs11569493; rs35028655; rs11569539; rs41500852; rs7252135; rs12971991; rs12609780; rs11569403; rs35473940; rs11569563; rs444056; rs11569569; rs7508631; rs12981329; rs11569586; rs35008633; rs28709832; rs34349609; rs11569567; rs34748637; rs413141; rs34208747; rs11569566; rs11569568; rs391757; rs28685640; rs10407174; rs7508533; rs2047138; rs2004271; rs446220; rs1077667; rs12981348; rs15234; rs171094; rs1862509; rs1862510; rs2291667; rs2291668; rs2642210; rs340126; rs344558; rs344614; rs344615; rs35263980; rs4082576; rs4490100; rs8112236

# Macromolecular_Interacting_Partner_11_General_References:
2579379; 1238393; 7539791; 6175959; 3279119; 1577777; 8416818; 12754519; 3260670; 9596584; 2473125; 2584723; 1976733; 7961791

# Macromolecular_Interacting_Partner_11_References:
7499866

# Macromolecular_Interacting_Partner_12_ID:
7886

# Macromolecular_Interacting_Partner_12_Name:
L-selectin precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antigen

# Macromolecular_Interacting_Partner_12_Gene_Name:
SELL

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Lselectin precursor
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDN
YTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPN
NKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTC
NCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETT
CGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKK
TICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKK
GKKSKRSMNDPY

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
42187

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
6.57

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Cell surface adhesion protein. Mediate the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00008:EGF;
PF00059:Lectin_C;
PF00084:Sushi

# Macromolecular_Interacting_Partner_12_Signals:
1-28

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
333-355

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
307134

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
LYAM1_HUMAN (P14151)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SELL

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SELL

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:10720

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1119 bp
ATGATATTTCCATGGAAATGTCAGAGCACCCAGAGGGACTTATGGAACATCTTCAAGTTG
TGGGGGTGGACAATGCTCTGTTGTGATTTCCTGGCACATCATGGAACCGACTGCTGGACT
TACCATTATTCTGAAAAACCCATGAACTGGCAAAGGGCTAGAAGATTCTGCCGAGACAAT
TACACAGATTTAGTTGCCATACAAAACAAGGCGGAAATTGAGTATCTGGAGAAGACTCTG
CCTTTCAGTCGTTCTTACTACTGGATAGGAATCCGGAAGATAGGAGGAATATGGACGTGG
GTGGGAACCAACAAATCTCTTACTGAAGAAGCAGAGAACTGGGGAGATGGTGAGCCCAAC
AACAAGAAGAACAAGGAGGACTGCGTGGAGATCTATATCAAGAGAAACAAAGATGCAGGC
AAATGGAACGATGACGCCTGCCACAAACTAAAGGCAGCCCTCTGTTACACAGCTTCTTGC
CAGCCCTGGTCATGCAGTGGCCATGGAGAATGTGTAGAAATCATCAATAATTACACCTGC
AACTGTGATGTGGGGTACTATGGGCCCCAGTGTCAGCTTGTGATTCAGTGTGAGCCTTTG
GAGGCCCCAGAGCTGGGTACCATGGACTGTACTCACCCTTTGGGAAACTTCAGCTTCAGC
TCACAGTGTGCCTTCAGCTGCTCTGAAGGAACAAACTTAACTGGGATTGAAGAAACCACC
TGTGGACCATTTGGAAACTGGTCATCTCCAGAACCAACCTGTCAAGTGATTCAGTGTGAG
CCTCTATCAGCACCAGATTTGGGGATCATGAACTGTAGCCATCCCCTGGCCAGCTTCAGC
TTTACCTCTGCATGTACCTTCATCTGCTCAGAAGGAACTGAGTTAATTGGGAAGAAGAAA
ACCATTTGTGAATCATCTGGAATCTGGTCAAATCCTAGTCCAATATGTCAAAAATTGGAC
AAAAGTTTCTCAATGATTAAGGAGGGTGATTATAACCCCCTCTTCATTCCAGTGGCAGTC
ATGGTTACTGCATTCTCTGGGTTGGCATTTATCATTTGGCTGGCAAGGAGATTAAAAAAA
GGCAAGAAATCCAAGAGAAGTATGAATGACCCATATTAA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M25280

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_12_Locus:
1q23-q25

# Macromolecular_Interacting_Partner_12_SNPs:
rs3177980; rs4987382; rs4987310; rs1051091; rs4987286; rs4987279; rs4987394; rs909628; rs7553; rs12938; rs2205848; rs2223286; rs964556; rs1883228; rs2205847; rs4987373; rs7418242; rs4987353; rs2420381; rs4427452; rs4987367; rs964555; rs4987369; rs4987318; rs4987351; rs4987360; rs4987354; rs2298900; rs4656189; rs4987285; rs4987314; rs4987358; rs4987299; rs4987347; rs4987304; rs4987381; rs4987345; rs4987396; rs4987361; rs4987316; rs4987339; rs2298899; rs4140655; rs4987306; rs4987376; rs4987379; rs4987352; rs10919222; rs4987343; rs4987307; rs4987331; rs4987320; rs4987364; rs12072966; rs4987302; rs4987323; rs4987313; rs4987370; rs4987366; rs1883229; rs2298901; rs964557; rs4987284; rs4987400; rs4987317; rs4987281; rs1569457; rs4987325; rs12137905; rs3766129; rs4987328; rs4987278; rs4656697; rs4987395; rs4987338; rs4987301; rs4987292; rs4987363; rs4987322; rs4987342; rs4987275; rs4987340; rs12087033; rs4987315; rs4987324; rs2298902; rs4987287; rs4987403; rs4987368; rs4987337; rs4987291; rs4987276; rs4987404; rs12029669; rs4987319; rs4987273; rs4987327; rs4987293; rs4987280; rs4987341; rs4987397; rs4987282; rs4987372; rs4987346; rs4987300; rs4987380; rs4987298; rs4987297; rs4987375; rs4987277; rs4987303; rs4987355; rs4987359; rs4987326; rs4987321; rs4987350; rs4987308; rs4987305; rs4987311; rs4987283; rs4987332; rs4987288; rs17525350; rs4987333; rs4987362; rs4987296; rs4987399; rs4987330; rs4987357; rs4987349; rs4987371; rs4987377; rs12034295; rs4987391; rs4987389; rs2205849; rs4987384; rs4987388; rs4987270; rs4987265; rs4987268; rs4987266; rs4987393; rs4987272; rs4987267; rs4987386; rs4987271; rs4987309; rs13306835; rs12758669; rs4987383; rs4987406; rs41272473; rs6688874; rs11282890; rs4987356; rs4987289; rs35384355; rs6662759; rs35466992; rs4987334; rs4987378; rs34442887; rs33928184; rs35664690; rs4987295; rs4987329; rs12036937; rs4987348; rs4987336; rs4987401; rs4987274; rs10919223; rs4987402; rs4987374; rs4987290; rs4987344; rs4987312; rs6701685; rs12087116; rs35383673; rs4987405; rs13306834; rs34922988; rs4987294; rs4987398; rs12126331; rs35787847; rs34753824; rs10654815; rs28634201; rs35535713; rs4987365; rs12120772; rs4987335; rs11363811; rs13306833; rs4987408; rs6656492; rs12045667; rs4987269; rs4987410; rs4987385; rs4987407; rs6680979; rs12065232; rs3835455; rs4987409; rs4987390; rs4987392; rs4987387; rs12079552; rs35793047; rs12036888; rs12038193; rs12038568; rs12043338; rs12046180; rs12046209; rs12049148; rs12076368; rs12133642; rs12133666; rs12134971; rs12723862; rs12738302; rs12738329; rs12743104; rs17524608; rs2420504; rs34164630; rs4363475; rs4656698; rs4656699; rs4656700; rs4656701; rs4656703; rs6427212; rs6693963; rs7531464; rs7531806; rs7543304

# Macromolecular_Interacting_Partner_12_General_References:
2664786; 2473156; 2509939; 2663882; 1692315; 7488174

# Macromolecular_Interacting_Partner_12_References:
10644477; 10849115; 10914491; 11071858

# Macromolecular_Interacting_Partner_13_ID:
7905

# Macromolecular_Interacting_Partner_13_Name:
T-cell surface glycoprotein CD1e precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
CD1e antigen; R2G1

# Macromolecular_Interacting_Partner_13_Gene_Name:
CD1E

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Tcell surface glycoprotein CD1e precursor
MLLLFLLFEGLCCPGENTAAAEEQLSFRMLQTSSFANHSWAHSEGSGWLGDLQTHGWDTV
LGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYPFEIQILAGCR
MNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKEILQSLLGHTC
PRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQE
QRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIHWGGYSIFLIL
ICLTVIVTLVILVVVDSRLKKQ

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
322

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
35986

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
7.25

# Macromolecular_Interacting_Partner_13_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF07654:C1-set

# Macromolecular_Interacting_Partner_13_Signals:
1-19

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
295-315

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
296640

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
CD1E_HUMAN (P15812)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CD1E

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CD1E

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:1638

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>972 bp
ATGCTGCTCCTGTTCCTCCTCTTCGAGGGTCTCTGCTGTCCTGGGGAAAATACAGCAGCA
GCAGAGGAGCAGCTGTCCTTCCGCATGCTCCAAACTTCCTCCTTTGCCAACCACAGCTGG
GCACACAGTGAGGGCTCAGGATGGCTGGGTGACCTGCAGACTCATGGCTGGGACACTGTC
TTGGGCACCATCCGCTTTCTGAAGCCCTGGTCCCATGGAAACTTCAGCAAGCAGGAGCTG
AAAAACTTACAGTCACTGTTCCAGTTATACTTCCATAGTTTTATCCAGATAGTGCAAGCT
TCTGCTGGTCAATTTCAGCTTGAATACCCCTTCGAGATCCAGATATTAGCTGGCTGTAGA
ATGAATGCCCCACAAATCTTCTTAAATATGGCATATCAAGGGTCAGATTTCCTGAGTTTC
CAAGGAATTTCCTGGGAGCCATCTCCAGGAGCAGGGATCCGGGCCCAGAACATCTGTAAA
GTGCTCAATCGCTACCTAGATATTAAGGAAATACTGCAAAGCCTTCTTGGTCACACCTGC
CCTCGATTTCTAGCGGGGCTCATGGAAGCAGGGGAGTCAGAACTGAAACGGAAAGTGAAG
CCAGAGGCCTGGCTGTCCTGTGGCCCCAGTCCTGGCCCTGGCCGTCTGCAGCTTGTGTGC
CATGTCTCAGGATTCTACCCAAAGCCCGTGTGGGTGATGTGGATGCGGGGTGAGCAGGAG
CAGCGGGGCACTCAGCGAGGGGACGTCCTGCCTAATGCTGACGAGACATGGTATCTCCGA
GCAACCCTGGATGTGGCGGCTGGGGAGGCAGCTGGCCTGTCCTGTCGGGTGAAACACAGC
AGTCTAGGGGGCCATGATCTAATCATCCATTGGGGTGGATATTCCATCTTTCTCATCCTG
ATCTGTTTGACTGTGATAGTTACCCTGGTCATATTGGTTGTAGTTGACTCACGGTTAAAA
AAACAGAGGTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
X14975

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_13_Locus:
1q22-q23

# Macromolecular_Interacting_Partner_13_SNPs:
rs1065457; rs2873587; rs16840106; rs11809955; rs11805538; rs11804812; rs858565; rs9729737; rs11809933; rs11806627; rs35079671; rs3180089; rs35116276; rs35736767; rs36041664; rs35965526; rs34913045; rs41273487; rs35184522; rs34393144; rs10908648; rs11264959; rs11264960; rs11264962; rs11264963; rs11581936; rs11584245; rs11586713; rs11588320; rs11799792; rs11807851; rs11808256; rs11809011; rs11809338; rs12023386; rs12038925; rs12084190; rs12139388; rs12726939; rs12736034; rs12742463; rs12754843; rs2106085; rs2106086; rs2157684; rs2317955; rs34460006; rs34633423; rs35752748; rs765629; rs858566

# Macromolecular_Interacting_Partner_13_General_References:
2467814; 10488738; 3097645; 11019917

# Macromolecular_Interacting_Partner_13_References:
11956292

# Macromolecular_Interacting_Partner_14_ID:
8289

# Macromolecular_Interacting_Partner_14_Name:
T-cell surface glycoprotein CD1d precursor

# Macromolecular_Interacting_Partner_14_Synonyms:
CD1d antigen; R3G1

# Macromolecular_Interacting_Partner_14_Gene_Name:
CD1D

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Tcell surface glycoprotein CD1d precursor
MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSN
DSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGC
EVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLL
NGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMR
GEQEQQGTQPGDILPNADETWYLRATLDVVAGEAAGLSCRVKHSSLEGQDIVLYWGGSYT
SMGLIALAVLACLLFLLIVGFTSRFKRQTSYQGVL

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
335

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
37718

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.28

# Macromolecular_Interacting_Partner_14_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Not known

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07654:C1-set

# Macromolecular_Interacting_Partner_14_Signals:
1-19

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
302-322

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
619798

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
CD1D_HUMAN (P15813)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
CD1D

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
CD1D

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:1637

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1008 bp
ATGGGGTGCCTGCTGTTTCTGCTGCTCTGGGCGCTCCTCCAGGCTTGGGGAAGCGCTGAA
GTCCCGCAAAGGCTTTTCCCCCTCCGCTGCCTCCAGATCTCGTCCTTCGCCAATAGCAGC
TGGACGCGCACCGACGGCTTGGCGTGGCTGGGGGAGCTGCAGACGCACAGCTGGAGCAAC
GACTCGGACACCGTCCGCTCTCTGAAGCCTTGGTCCCAGGGCACGTTCAGCGACCAGCAG
TGGGAGACGCTGCAGCATATATTTCGGGTTTATCGAAGCAGCTTCACCAGGGACGTGAAG
GAATTCGCCAAAATGCTACGCTTATCCTATCCCTTGGAGCTCCAGGTGTCCGCTGGCTGT
GAGGTGCACCCTGGGAACGCCTCAAATAACTTCTTCCATGTAGCATTTCAAGGAAAAGAT
ATCCTGAGTTTCCAAGGAACTTCTTGGGAGCCAACCCAAGAGGCCCCACTTTGGGTAAAC
TTGGCCATTCAAGTGCTCAACCAGGACAAGTGGACGAGGGAAACAGTGCAGTGGCTCCTT
AATGGCACCTGCCCCCAATTTGTCAGTGGCCTCCTTGAGTCAGGGAAGTCGGAACTGAAG
AAGCAAGTGAAGCCCAAGGCCTGGCTGTCCCGTGGCCCCAGTCCTGGCCCTGGCCGTCTG
CTGCTGGTGTGCCATGTCTCAGGATTCTACCCAAAGCCTGTATGGGTGAAGTGGATGCGG
GGTGAGCAGGAGCAGCAGGGCACTCAGCCAGGGGACATCCTGCCCAATGCTGACGAGACA
TGGTATCTCCGAGCAACCCTGGATGTGGTGGCTGGGGAGGCAGCTGGCCTGTCCTGTCGG
GTGAAGCACAGCAGTCTAGAGGGCCAGGACATCGTCCTCTACTGGGGTGGGAGCTACACC
TCCATGGGCTTGATTGCCTTGGCAGTCCTGGCGTGCTTGCTGTTCCTCCTCATTGTGGGC
TTTACCTCCCGGTTTAAGAGGCAAACTTCCTATCAGGGCGTCCTGTGA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
L38820

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_14_Locus:
1q22-q23

# Macromolecular_Interacting_Partner_14_SNPs:
rs859008; rs3754471; rs859010; rs859009; rs859015; rs426336; rs7524536; rs859011; rs859012; rs859013; rs692565; rs422236; rs11762; rs3754469; rs16839909; rs35388773; rs4369228; rs1565845; rs34984399; rs1624778; rs3021481; rs1324656; rs1617972; rs1617977; rs1618045; rs1618053; rs1619547; rs1633121; rs1633122; rs1633123; rs1690769; rs1690771; rs1690772; rs1690774; rs1748362; rs1748363; rs1748365; rs1748366; rs1748372; rs1748373; rs1748374; rs1748375; rs1980757; rs2023631; rs3021476; rs3021477; rs3021479; rs3021480; rs3021485; rs3021486; rs3087210; rs3087211; rs3087213; rs371380; rs3754472; rs385250; rs404362; rs420491; rs6671299; rs859003; rs859004; rs859005; rs859006; rs859007; rs973742; rs980937

# Macromolecular_Interacting_Partner_14_General_References:
2467814; 2463622; 10488738; 3097645

# Macromolecular_Interacting_Partner_14_References:
15051763; 16314439

# Macromolecular_Interacting_Partner_15_ID:
7923

# Macromolecular_Interacting_Partner_15_Name:
Galectin-3

# Macromolecular_Interacting_Partner_15_Synonyms:
Galactose-specific lectin 3; Mac-2 antigen; IgE-binding protein; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Laminin-binding protein; Lectin L-29; L-31; Galactoside-binding protein; GALBP

# Macromolecular_Interacting_Partner_15_Gene_Name:
LGALS3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Galectin3
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPP
GAYHGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSAPGAYPATGPYGAPAGPLIVPYNL
PLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNN
WGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDI
DLTSASYTMI

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
250

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
26189

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
179531

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
LEG3_HUMAN (P17931)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
LGALS3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
LGALS3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6563

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Nucleus. Note=Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>753 bp
ATGGCAGACAATTTTTCGCTCCATGATGCGTTATCTGGGTCTGGAAACCCAAACCCTCAA
GGATGGCCTGGCGCATGGGGGAACCAGCCTGCTGGGGCAGGGGGCTACCCAGGGGCTTCC
TATCCTGGGGCCTACCCCGGGCAGGCACCCCCAGGGGCTTATCCTGGACAGGCACCTCCA
GGCGCCTACCATGGAGCACCTGGAGCTTATCCCGGAGCACCTGCACCTGGAGTCTACCCA
GGGCCACCCAGCGGCCCTGGGGCCTACCCATCTTCTGGACAGCCAAGTGCCCCCGGAGCC
TACCCTGCCACTGGCCCCTATGGCGCCCCTGCTGGGCCACTGATTGTGCCTTATAACCTG
CCTTTGCCTGGGGGAGTGGTGCCTCGCATGCTGATAACAATTCTGGGCACGGTGAAGCCC
AATGCAAACAGAATTGCTTTAGATTTCCAAAGAGGGAATGATGTTGCCTTCCACTTTAAC
CCACGCTTCAATGAGAACAACAGGAGAGTCATTGTTTGCAATACAAAGCTGGATAATAAC
TGGGGAAGGGAAGAAAGACAGTCGGTTTTCCCATTTGAAAGTGGGAAACCATTCAAAATA
CAAGTACTGGTTGAACCTGACCACTTCAAGGTTGCAGTGAATGATGCTCACTTGTTGCAG
TACAATCATCGGGTTAAAAAACTCAATGAAATCAGCAAACTGGGAATTTCTGGTGACATA
GACCTCACCAGTGCTTCATATACCATGATATAA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
M57710

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_15_Locus:
14q21-q22

# Macromolecular_Interacting_Partner_15_SNPs:
rs7157768; rs1047556; rs8012397; rs10149038; rs3188651; rs7160110; rs7160523; rs2147972; rs35624648; rs35652569; rs3188650; rs12161901; rs1130118; rs10629608; rs10629194; rs17095981; rs7159530; rs34212935; rs3742566; rs1009977; rs1009978; rs10140857; rs10146432; rs10148371; rs1042869; rs1042896; rs1042906; rs1042918; rs10498475; rs11001; rs11622740; rs13379284; rs15870; rs17128204; rs17128230; rs17128262; rs2075598; rs2075601; rs2075602; rs2075603; rs2182207; rs2274272; rs2274273; rs2296490; rs2340931; rs2340932; rs28405981; rs28415601; rs35954941; rs3818451; rs3825613; rs4644; rs7493394; rs8007614; rs8007620; rs8013027

# Macromolecular_Interacting_Partner_15_General_References:
2261464; 2402511; 2022338; 2009535; 7682704; 8253806; 9501082; 9582341

# Macromolecular_Interacting_Partner_15_References:
1733769; 1958194; 2303431; 2745433

# Macromolecular_Interacting_Partner_16_ID:
7895

# Macromolecular_Interacting_Partner_16_Name:
Myelin-associated glycoprotein precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
Siglec-4a

# Macromolecular_Interacting_Partner_16_Gene_Name:
MAG

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Myelinassociated glycoprotein precursor
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGD
LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
GEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPP
VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAED
GVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIF
KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESH
CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQA
QAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
NVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHS
DLGKRPTKDSYTLTEELAEYAEIRVK

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
626

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
69069

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
4.69

# Macromolecular_Interacting_Partner_16_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF08205:C2-set_2;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_16_Signals:
1-19

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
517-536

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
307156

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
MAG_HUMAN (P20916)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
MAG

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
MAG

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:6783

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1881 bp
ATGATATTCCTCACGGCACTGCCTCTGTTCTGGATTATGATTTCAGCCTCCCGAGGGGGT
CACTGGGGTGCCTGGATGCCCTCGTCCATCTCGGCCTTCGAAGGCACGTGCGTCTCCATC
CCCTGCCGCTTTGACTTCCCGGATGAGCTGCGGCCCGCTGTGGTGCATGGTGTCTGGTAC
TTCAATAGCCCCTACCCCAAGAACTACCCCCCGGTGGTCTTCAAGTCGCGCACCCAAGTA
GTCCACGAGAGCTTCCAGGGCCGCAGCCGCCTCCTGGGGGACCTGGGCCTGCGAAACTGC
ACCCTCCTGCTCAGCAACGTCAGCCCCGAGCTGGGCGGGAAGTACTACTTCCGTGGGGAC
CTGGGCGGCTACAACCAGTACACCTTCTCAGAGCACAGTGTCCTGGATATCGTCAACACC
CCCAACATCGTGGTGCCCCCAGAGGTGGTGGCAGGCACGGAGGTGGAGGTCAGCTGCATG
GTGCCGGACAACTGCCCAGAGCTGCGCCCTGAGCTGAGCTGGCTGGGCCACGAGGGGCTG
GGGGAGCCCGCTGTGCTGGGCCGGCTGCGGGAGGACGAGGGCACCTGGGTGCAGGTGTCA
CTGCTGCACTTCGTGCCCACGAGGGAGGCCAACGGCCACAGGCTGGGCTGCCAGGCCTCC
TTCCCCAACACCACCCTGCAGTTCGAGGGCTACGCCAGCATGGACGTCAAGTACCCCCCG
GTGATTGTGGAGATGAACTCCTCGGTGGAGGCCATCGAGGGCTCCCACGTGAGCCTGCTC
TGTGGGGCTGACAGCAACCCCCCGCCGCTGCTGACCTGGATGCGGGACGGGACAGTCCTC
CGGGAGGCGGTGGCCGAGAGCCTGCTCCTGGAGCTGGAGGAGGTGACCCCCGCCGAAGAC
GGCGTCTATGCCTGCCTGGCCGAGAATGCCTATGGCCAGGACAACCGCACCGTGGGGCTC
AGTGTCATGTATGCACCCTGGAAGCCAACAGTGAACGGGACAATGGTGGCCGTAGAGGGG
GAGACGGTCTCTATCTTGTGCTCCACACAGAGCAACCCGGACCCTATTCTCACCATCTTC
AAGGAGAAGCAGATCCTGTCCACGGTCATCTACGAGAGCGAGCTGCAGCTGGAGCTGCCC
GCCGTGTCACCCGAGGATGATGGAGAGTACTGGTGTGTGGCTGAGAACCAGTATGGCCAG
AGGGCCACCGCCTTCAACCTGTCTGTGGAGTTCGCCCCTGTGCTCCTCCTGGAGTCCCAC
TGCGCGGCAGCCCGAGACACGGTGCAGTGCCTGTGCGTGGTGAAGTCCAACCCGGAGCCG
TCCGTGGCCTTTGAGCTGCCATCGCGCAATGTGACCGTGAACGAGAGCGAGCGGGAGTTC
GTGTACTCGGAGCGCAGCGGCCTCGTGCTCACCAGCATCCTCACGCTGCGGGGGCAGGCC
CAGGCCCCGCCCCGCGTCATCTGCACCGCGAGGAACCTCTATGGCGCCAAGAGCCTGGAG
CTGCCCTTCCAGGGAGCCCATCGACTGATGTGGGCCAAGATCGGGCCTGTGGGCGCCGTG
GTCGCCTTTGCCATCCTGATTGCCATCGTCTGCTACATTACCCAGACACGCAGGAAAAAG
AACGTGACAGAGAGCCCCAGCTTCTCGGCAGGGGACAACCCTCCCGTCCTGTTCAGCAGC
GACTTCCGCATCTCTGGGGCACCAGAGAAGTACGAGAGCGAGAGGCGCCTGGGATCTGAG
AGGAGGCTGCTGGGCCTTCGGGGTGAGCCCCCAGAGCTGGACCTGAGCTATTCTCACTCG
GACCTGGGGAAACGGCCCACCAAGGACAGCTACACGCTGACGGAGGAGCTAGCTGAGTAT
GCTGAAATCCGGGTCAAGTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M29273

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_16_Locus:
19q13.1

# Macromolecular_Interacting_Partner_16_SNPs:
rs11084810; rs3746248; rs2301600; rs3746249; rs6510476; rs3214111; rs2285448; rs2285449; rs720309; rs12461927; rs10432275; rs720308; rs10414549; rs11669734; rs2269757; rs1964199; rs9304870; rs11670792; rs16970204; rs1034597; rs7249617; rs16970196; rs11879566; rs2285447; rs10414945; rs10411883; rs10402632; rs12185506; rs12974994; rs10411704; rs12974702; rs12185485; rs12608838; rs12608839; rs12608841; rs17705188; rs12609984; rs2301599; rs12609882; rs34074779; rs35237014; rs1126770; rs11550207; rs11550211; rs11550209; rs10670461; rs28508429; rs7248110; rs10557696; rs35311546; rs35676520; rs35662282; rs10678664; rs12976524; rs36141895; rs12974031; rs35981904; rs12972912; rs720307; rs41407744; rs10572816; rs10418687; rs36000294; rs35128289; rs12973162; rs10419210; rs35830760; rs2269756; rs12980495; rs35755792; rs12974264; rs12980521; rs2872113; rs12980281; rs35245828; rs11667965; rs3214112; rs35760221; rs12972861; rs8106733; rs16970192; rs12461872; rs12972627; rs12980353; rs2301598; rs12972629; rs12973965; rs12981372; rs12981415; rs3840948; rs12981404; rs10402233; rs10426926; rs11666282; rs11673191; rs11673522; rs12327820; rs12460277; rs12463142; rs12608868; rs12971321; rs12977217; rs12981829; rs16970218; rs17637981; rs17705279; rs2293689; rs3817623; rs4806126; rs7251432; rs7253838; rs7254710; rs756796; rs8101606

# Macromolecular_Interacting_Partner_16_General_References:
2476987; 2479762

# Macromolecular_Interacting_Partner_16_References:
1282933; 1706491; 2441800

# Macromolecular_Interacting_Partner_17_ID:
8062

# Macromolecular_Interacting_Partner_17_Name:
Midkine precursor

# Macromolecular_Interacting_Partner_17_Synonyms:
MK; Neurite outgrowth-promoting protein; Midgestation and kidney protein; Amphiregulin-associated protein; ARAP; Neurite outgrowth-promoting factor 2

# Macromolecular_Interacting_Partner_17_Gene_Name:
MDK

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Midkine precursor
MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT
CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
143

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
15585

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
10.49

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF01091:PTN_MK_C;
PF05196:PTN_MK_N

# Macromolecular_Interacting_Partner_17_Signals:
1-20

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
219929

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
MK_HUMAN (P21741)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
MDK

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
MDK

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:6972

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>432 bp
ATGCAGCACCGAGGCTTCCTCCTCCTCACCCTCCTCGCCCTGCTGGCGCTCACCTCCGCG
GTCGCCAAAAAGAAAGATAAGGTGAAGAAGGGCGGCCCGGGGAGCGAGTGCGCTGAGTGG
GCCTGGGGGCCCTGCACCCCCAGCAGCAAGGATTGCGGCGTGGGTTTCCGCGAGGGCACC
TGCGGGGCCCAGACCCAGCGCATCCGGTGCAGGGTGCCCTGCAACTGGAAGAAGGAGTTT
GGAGCCGACTGCAAGTACAAGTTTGAGAACTGGGGTGCGTGTGATGGGGGCACAGGCACC
AAAGTCCGCCAAGGCACCCTGAAGAAGGCGCGCTACAATGCTCAGTGCCAGGAGACCATC
CGCGTCACCAAGCCCTGCACCCCCAAGACCAAAGCAAAGGCCAAAGCCAAGAAAGGGAAG
GGAAAGGACTAG

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
D10604

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_17_Locus:
11p11.2

# Macromolecular_Interacting_Partner_17_SNPs:
rs20542; rs1051037; rs14156; rs35871643; rs11557367; rs34274885; rs34089965; rs7481848; rs11557366; rs11557364; rs34261502; rs35324223; rs34864824; rs12801059; rs35008178; rs11038883; rs11822150; rs11823766; rs11827909; rs2046768; rs2229163; rs2279465; rs33968054; rs35646260; rs3740974; rs3740976; rs3740977; rs7107481; rs7936413

# Macromolecular_Interacting_Partner_17_General_References:
1639750; 2025291; 8471163; 1883381; 9384573

# Macromolecular_Interacting_Partner_17_References:
10632704

# Macromolecular_Interacting_Partner_18_ID:
7796

# Macromolecular_Interacting_Partner_18_Name:
ETS domain-containing protein Elk-4

# Macromolecular_Interacting_Partner_18_Synonyms:
Serum response factor accessory protein 1; SAP-1

# Macromolecular_Interacting_Partner_18_Gene_Name:
ELK4

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>ETS domaincontaining protein Elk4
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLS
RALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDV
ENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKS
PQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPT
SASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEP
KDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQ
TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPST
PGPFSPDLQKT

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
431

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
46900

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
8.19

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00178:Ets

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
429186

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ELK4_HUMAN (P28324)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
ELK4

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
ELK4

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:3326

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1296 bp
ATGGACAGTGCTATCACCCTGTGGCAGTTCCTTCTTCAGCTCCTGCAGAAGCCTCAGAAC
AAGCACATGATCTGTTGGACCTCTAATGATGGGCAGTTTAAGCTTTTGCAGGCAGAAGAG
GTGGCTCGTCTCTGGGGGATTCGCAAGAACAAGCCTAACATGAATTATGACAAACTCAGC
CGAGCCCTCAGATACTATTATGTAAAGAATATCATCAAAAAAGTGAATGGTCAGAAGTTT
GTGTACAAGTTTGTCTCTTATCCAGAGATTTTGAACATGGATCCAATGACAGTGGGCAGG
ATTGAGGGTGACTGTGAAAGTTTAAACTTCAGTGAAGTCAGCAGCAGTTCCAAAGATGTG
GAGAATGGAGGGAAAGATAAACCACCTCAGCCTGGTGCCAAGACCTCTAGCCGCAATGAC
TACATACACTCTGGCTTATATTCTTCATTTACTCTCAACTCTTTGAACTCCTCCAATGTA
AAGCTTTTCAAATTGATAAAGACTGAGAATCCAGCCGAGAAACTGGCAGAGAAAAAATCT
CCTCAGGAGCCCACACCATCTGTCATCAAATTTGTCACGACACCTTCCAAAAAGCCACCA
GTTGAACCTGTTGCTGCCACCATTTCAATTGGCCCAAGTATTTCTCCATCTTCAGAAGAA
ACTATCCAAGCTTTGGAGACATTGGTTTCCCCAAAACTGCCTTCCCTGGAAGCCCCAACC
TCTGCCTCTAACGTAATGACTGCTTTTGCCACCACACCACCCATTTCGTCCATACCCCCT
TTGCAGGAACCTCCCAGAACACCTTCACCACCACTGAGTTCTCACCCAGACATCGACACA
GACATTGATTCAGTGGCTTCTCAGCCAATGGAACTTCCAGAGAATTTGTCTCTGGAGCCT
AAAGACCAGGATTCAGTCTTGCTAGAAAAGGACAAAGTAAATAATTCATCAAGATCCAAG
AAACCCAAAGGGTTAGGACTGGCACCCACCCTTGTGATCACGAGCAGTGATCCAAGCCCA
CTGGGAATACTGAGCCCATCTCTCCCTACAGCTTCTCTTACACCAGCATTTTTTTCACAG
ACACCCATCATACTGACTCCAAGCCCCTTGCTCTCCAGTATCCACTTCTGGAGTACTCTC
AGTCCTGTTGCTCCCCTAAGTCCAGCCAGACTGCAAGGTGCTAACACACTTTTCCAGTTT
CCTTCTGTACTGAACAGTCATGGGCCATTCACTCTGTCTGGGCTGGATGGACCTTCCACC
CCTGGCCCATTTTCCCCAGACCTACAGAAGACATAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
M85165

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q32

# Macromolecular_Interacting_Partner_18_SNPs:
rs1064406; rs3789461; rs12024592; rs11240541; rs4951247; rs2185811; rs3088136; rs12048882; rs6593957; rs4951248; rs7417466; rs7416757; rs12059129; rs4245717; rs13757; rs2867891; rs12023128; rs7549710; rs7523896; rs12731801; rs11590243; rs10900517; rs11577251; rs6593958; rs6593959; rs3204653; rs34515238; rs1064407; rs5780290; rs35619827; rs33980729; rs36121780; rs5780291; rs3208701; rs35018164; rs34851857; rs36056386; rs12048270; rs34193126; rs34460220; rs4951016; rs3065075; rs35020975; rs7416754; rs12048218; rs7416797; rs35663317; rs10635021; rs7416784; rs35267180; rs4951015; rs4951246; rs28630447; rs3208700; rs12025838; rs35375451; rs34724628; rs12749476; rs12738516; rs28629959; rs12732062; rs11379300; rs10701824; rs34310773; rs28495285; rs35245252; rs34087906; rs9729302; rs28435573; rs12759464; rs3204652; rs36044648; rs28571118; rs34180074; rs12727121; rs34779537; rs35219050; rs35600482; rs10793741; rs10900516; rs10900518; rs1114126; rs11579421; rs11579937; rs11580704; rs11581303; rs12039255; rs12080192; rs12087328; rs12125386; rs12565766; rs17347710; rs2226161; rs2867892; rs34103393; rs34451491; rs4130248; rs4130249; rs4573566; rs6661827; rs7518313

# Macromolecular_Interacting_Partner_18_General_References:
1339307; 8293474; 9734357

# Macromolecular_Interacting_Partner_18_References:
1350885; 1689485; 2019586; 3242555

# Macromolecular_Interacting_Partner_19_ID:
8202

# Macromolecular_Interacting_Partner_19_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_19_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_19_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_19_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_19_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_19_Locus:
10q22

# Macromolecular_Interacting_Partner_19_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_19_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_19_References:
11739312

# Macromolecular_Interacting_Partner_20_ID:
8403

# Macromolecular_Interacting_Partner_20_Name:
ADAMTS-like protein 1 precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
ADAMTSL-1; Punctin-1

# Macromolecular_Interacting_Partner_20_Gene_Name:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>
ADAMTSlike protein 1 precursorMECCRRATPGTLLLFLAFLLLSSRTARSEE
DRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRA
QQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLD
MCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPY
GSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGP
LTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN
RVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSS
SCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTV
TCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQ
AQELEEGAAVSEEPS

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
525

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
58417

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.65

# Macromolecular_Interacting_Partner_20_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00090:TSP_1

# Macromolecular_Interacting_Partner_20_Signals:
1-28

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
15099921

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ATL1_HUMAN (Q8N6G6)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
ADAMTSL1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:14632

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1578 bp
ATGGAATGCTGCCGTCGGGCAACTCCTGGCACACTGCTCCTCTTTCTGGCTTTCCTGCTC
CTGAGTTCCAGGACCGCACGCTCCGAGGAGGACCGGGACGGCCTATGGGATGCCTGGGGC
CCATGGAGTGAATGCTCACGCACCTGCGGGGGTGGGGCCGCCAACTCTCTGAGGCGCTGC
CTGAGCAGCAAGAGCTGTGAAGGAAGAAATATCCGATACAGAACATGCAGTAATGTGGAC
TGCCCACCAGAAGCAGGTGATTTCCGAGCTCAGCAATGCTCAGCTCATAATGATGTCAAG
CACCATGGCCAGTTTTATGAATGGCTTCCTGTGTCTAATGACCCTGACAACCCATGTTCA
CTCAAGTGCCAAGCCAAAGGAACAACCCTGGTTGTTGAACTAGCACCTAAGGTCTTAGAT
GGTACGCGTTGCTATACAGAATCTTTGGATATGTGCATCAGTGGTTTATGCCAAATTGTT
GGCTGCGATCACCAGCTGGGAAGCACCGTCAAGGAAGATAACTGTGGGGTCTGCAACGGA
GATGGGTCCACCTGCCGGCTGGTCCGAGGGCAGTATAAATCCCAGCTCTCCGCAACCAAA
TCGGATGATACTGTGGTTGCAATTCCCTATGGAAGTAGACATATTCGCCTTGTCTTAAAA
GGTCCTGATCACTTATATCTGGAAACCAAAACCCTCCAGGGGACTAAAGGTGAAAACAGT
CTCAGCTCCACAGGAACTTTCCTTGTGGACAATTCTAGTGTGGACTTCCAGAAATTTCCA
GACAAAGAGATACTGAGAATGGCTGGACCACTCACAGCAGATTTCATTGTCAAGATTCGT
AACTCGGGCTCCGCTGACAGTACAGTCCAGTTCATCTTCTATCAACCCATCATCCACCGA
TGGAGGGAGACGGATTTCTTTCCTTGCTCAGCAACCTGTGGAGGAGGTTATCAGCTGACA
TCGGCTGAGTGCTACGATCTGAGGAGCAACCGTGTGGTTGCTGACCAATACTGTCACTAT
TACCCAGAGAACATCAAACCCAAACCCAAGCTTCAGGAGTGCAACTTGGATCCTTGTCCA
GCCAGTGACGGATACAAGCAGATCATGCCTTATGACCTCTACCATCCCCTTCCTCGGTGG
GAGGCCACCCCATGGACCGCGTGCTCCTCCTCGTGTGGGGGGGGCATCCAGAGCCGGGCA
GTTTCCTGTGTGGAGGAGGACATCCAGGGGCATGTCACTTCAGTGGAAGAGTGGAAATGC
ATGTACACCCCTAAGATGCCCATCGCGCAGCCCTGCAACATTTTTGACTGCCCTAAATGG
CTGGCACAGGAGTGGTCTCCGTGCACAGTGACGTGTGGCCAGGGCCTCAGATACCGTGTG
GTCCTCTGCATCGACCATCGAGGAATGCACACAGGAGGCTGTAGCCCAAAAACAAAGCCC
CACATAAAAGAGGAATGCATCGTACCCACTCCCTGCTATAAACCCAAAGAGAAACTTCCA
GTCGAGGCCAAGTTGCCATGGTTCAAACAAGCTCAAGAGCTAGAAGAAGGAGCTGCTGTG
TCAGAGGAGCCCTCGTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AF176313

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_20_Locus:
9p22.2-p22.1

# Macromolecular_Interacting_Partner_20_SNPs:
rs776755; rs16936832; rs13293151; rs2277160; rs1412672; rs776761; rs776760; rs16923421; rs10963719; rs776785; rs1360566; rs1341063; rs2811802; rs776758; rs547927; rs2066254; rs702207; rs1329720; rs530120; rs566332; rs1341060; rs1928534; rs517764; rs776764; rs2570569; rs1341070; rs1889010; rs1889007; rs1341059; rs1147795; rs559385; rs702204; rs1539000; rs1341062; rs1412673; rs1889009; rs1538999; rs776780; rs556720; rs702208; rs572429; rs1891042; rs526826; rs1361533; rs1281349; rs4961653; rs11792038; rs1999489; rs12554902; rs7047451; rs4977520; rs702202; rs10810993; rs10756975; rs10511661; rs2149875; rs518607; rs10963665; rs7867475; rs7036515; rs10756969; rs7045779; rs1821376; rs1832746; rs11794207; rs4977292; rs10963622; rs1341061; rs4977341; rs2065467; rs10733355; rs6475238; rs10963684; rs1332708; rs7875881; rs6475236; rs944719; rs10963639; rs702206; rs10963693; rs4977522; rs10963713; rs568935; rs10756977; rs1582017; rs776770; rs702209; rs1934931; rs1341058; rs1006022; rs10810981; rs7863523; rs4433237; rs6475230; rs7864622; rs10756981; rs10756970; rs10811002; rs7039094; rs6475226; rs4961652; rs7862714; rs7023164; rs6475232; rs7874290; rs10756976; rs10963615; rs949682; rs1889005; rs1832747; rs10811022; rs1332706; rs7041523; rs2225568; rs4607718; rs7031222; rs7864727; rs1332712; rs10811006; rs2779127; rs3739569; rs4961654; rs776771; rs6475228; rs2096067; rs7029420; rs7027141; rs7029284; rs1341057; rs7019399; rs4977340; rs1582016; rs944720; rs10811007; rs2779125; rs1889006; rs10756982; rs483950; rs2482972; rs6475227; rs7856703; rs870019; rs7042159; rs10963673; rs2095100; rs10963729; rs16936757; rs2184002; rs776790; rs482009; rs2383077; rs1576897; rs16936909; rs7388822; rs7390384; rs7042143; rs10810985; rs1332707; rs7859309; rs10963624; rs7874890; rs12345096; rs13300372; rs702205; rs13299098; rs7025447; rs10481563; rs10963689; rs10116116; rs1341067; rs10756973; rs12003267; rs1576900; rs7865575; rs10963629; rs1281352; rs7046774; rs17229989; rs7874996; rs1417640; rs11794163; rs1934932; rs7019258; rs2383075; rs776773; rs11789527; rs947144; rs10810991; rs10963669; rs10435773; rs12001790; rs10810974; rs11790127; rs11794157; rs7018651; rs17229415; rs2153415; rs10963675; rs11788108; rs12001049; rs7863071; rs16936815; rs7022259; rs776779; rs776756; rs10963691; rs10963662; rs2383079; rs1010529; rs11789989; rs4977339; rs776777; rs12554668; rs16936951; rs16936796; rs951227; rs11793923; rs776794; rs776754; rs776748; rs2482971; rs10115066; rs12684130; rs12000949; rs10811012; rs776781; rs7023698; rs1083111; rs10963664; rs10810997; rs4474116; rs521546; rs479642; rs7027296; rs16936905; rs17206601; rs10756968; rs16936779; rs11999281; rs10963630; rs10732338; rs12237559; rs1341069; rs12684350; rs10810995; rs552677; rs4961650; rs10738515; rs776776; rs7465987; rs1591108; rs1341065; rs4977338; rs10963667; rs1891043; rs488627; rs10810988; rs10963695; rs16936853; rs9792478; rs12000950; rs10756974; rs2811800; rs16936911; rs10810992; rs7036067; rs10481564; rs10810999; rs572484; rs17804334; rs702203; rs11792817; rs10811008; rs2153416; rs776766; rs11789831; rs7849918; rs1928535; rs12002347; rs776782; rs2383076; rs13298611; rs776791; rs532101; rs1341066; rs11789771; rs552295; rs12005242; rs776769; rs7868375; rs10756972; rs10738514; rs7028087; rs10511637; rs10810986; rs6475225; rs10963676; rs11795307; rs1360567; rs17803363; rs17228625; rs521911; rs9696562; rs10756980; rs10963640; rs776778; rs17209122; rs529274; rs7019175; rs6475237; rs12001004; rs16936967; rs4451401; rs10511657; rs12554550; rs10963626; rs776753; rs10115096; rs10810984; rs776784; rs4977264; rs10810975; rs7863100; rs10963710; rs2000117; rs7466067; rs944718; rs10963642; rs16936961; rs10810989; rs10963685; rs573120; rs776768; rs12352788; rs2507120; rs10810996; rs575507; rs7023695; rs12003118; rs4977248; rs12345939; rs10119114; rs1856893; rs7031043; rs12001288; rs4961656; rs7388795; rs776762; rs1412671; rs776763; rs4977511; rs7868026; rs10810994; rs488536; rs10511660; rs4961651; rs16936958; rs575995; rs12684345; rs6475233; rs7389933; rs12001382; rs10963668; rs776789; rs10810976; rs10810987; rs10810982; rs2487477; rs480335; rs16936827; rs12553147; rs11795292; rs10756978; rs10963623; rs10963627; rs7466047; rs7023718; rs2151152; rs11787618; rs16936777; rs10811014; rs10963712; rs10217409; rs13292511; rs17230881; rs1361534; rs10963731; rs12686263; rs12352272; rs12343163; rs13300724; rs10963650; rs16936896; rs1433822; rs17801150; rs575155; rs10963688; rs6475234; rs13297223; rs1889008; rs776569; rs1930265; rs1361535; rs1832748; rs7043878; rs17230699; rs12344654; rs17207294; rs11789251; rs13293473; rs554082; rs13293062; rs7023843; rs12379776; rs10115095; rs10810980; rs35688527; rs7389198; rs13295522; rs7020435; rs4977326; rs10963633; rs10963670; rs12552620; rs17207339; rs12005343; rs10963726; rs7040355; rs13298248; rs13287935; rs13287455; rs12005478; rs10217753; rs10810998; rs12376154; rs16936780; rs7848360; rs10963718; rs7023368; rs16936897; rs10810983; rs2153621; rs16936783; rs16936798; rs1576899; rs13294657; rs10963686; rs10963649; rs10738513; rs7855730; rs10123053; rs13301259; rs16936919; rs10120778; rs2811798; rs16936935; rs13302086; rs7041415; rs11789724; rs4961657; rs7341804; rs7466106; rs10963692; rs10963682; rs1281351; rs10963672; rs10511658; rs11791689; rs11532901; rs1412670; rs16936801; rs10811010; rs10963703; rs4977510; rs7850641; rs13301913; rs1855120; rs10811020; rs776767; rs13296911; rs10810979; rs2811796; rs17206965; rs7465974; rs1930263; rs16936808; rs12337201; rs7850738; rs1544308; rs12380512; rs7388806; rs2151153; rs13292240; rs12683032; rs1576901; rs17206657; rs16936831; rs542956; rs13294696; rs7872574; rs776783; rs7870255; rs35277167; rs1856894; rs9919038; rs13295269; rs7867784; rs12686602; rs13293767; rs10963711; rs12336626; rs7028404; rs17229477; rs776752; rs947143; rs1832638; rs17804352; rs12341667; rs9407925; rs12686125; rs7023504; rs3927893; rs12376289; rs12336527; rs776788; rs16936819; rs1332711; rs10116980; rs11793849; rs7019410; rs7041815; rs7031573; rs12684149; rs16936788; rs1332709; rs16936903; rs7874771; rs12004058; rs7020916; rs10963636; rs572616; rs12338677; rs776757; rs10963732; rs7021213; rs10811003; rs1147797; rs17207028; rs12336779; rs13298257; rs9775632; rs10811001; rs16936895; rs776749; rs776750; rs10963621; rs7867817; rs13288800; rs7044968; rs12685259; rs10963683; rs2149876; rs7852457; rs10810978; rs13290343; rs10811018; rs10963661; rs12349321; rs12342475; rs502981; rs12000315; rs7469307; rs10963687; rs10756979; rs1009309; rs1970943; rs10963734; rs2184001; rs10963634; rs10811015; rs7390343; rs11793203; rs10963666; rs573484; rs7040072; rs4977387; rs951226; rs10811019; rs7868185; rs13299349; rs7468653; rs11793774; rs7852955; rs539785; rs10811011; rs12686145; rs776751; rs10963735; rs12339807; rs7390426; rs7044243; rs7034394; rs7864856; rs10963620; rs13300518; rs7023547; rs1888066; rs16936794; rs7855050; rs7027894; rs2225570; rs10115933; rs10963707; rs10511659; rs11999519; rs12337572; rs17229526; rs7867370; rs16936917; rs7035957; rs4355867; rs12551569; rs10963625; rs1576896; rs10810973; rs7875093; rs13292378; rs7850813; rs776765; rs6475221; rs10963657; rs10963704; rs10811021; rs16936775; rs7038168; rs10811000; rs16936817; rs7850363; rs16936818; rs16936963; rs10963694; rs4977287; rs16936852; rs10963680; rs1341071; rs7850469; rs12554156; rs10116792; rs10963696; rs486145; rs10963681; rs7867664; rs12000817; rs16936778; rs10963671; rs10732339; rs2507119; rs7019792; rs13294727; rs1576898; rs17801409; rs4431681; rs10963635; rs10963714; rs578602; rs1281350; rs522039; rs10511638; rs16936748; rs13286264; rs2507121; rs41268981; rs41298157; rs3833713; rs35537367; rs34092810; rs10963724; rs11364021; rs12340239; rs7858746; rs2779126; rs13292616; rs776793; rs36077277; rs13294946; rs36169929; rs36091497; rs35416683; rs34876631; rs36022692; rs9406756; rs36057123; rs10963716; rs34645177; rs10708564; rs4977282; rs5016291; rs36013602; rs33953582; rs2891130; rs34439536; rs35140301; rs35060497; rs776775; rs35316103; rs35606703; rs13297702; rs34631052; rs34680131; rs10963701; rs13288820; rs13299810; rs2210057; rs34726555; rs35875473; rs13292199; rs12236787; rs36031735; rs34052626; rs9792510; rs36168513; rs35803069; rs10963614; rs34506111; rs13283108; rs544787; rs34597500; rs35108345; rs35071367; rs2383081; rs13286126; rs11460080; rs34654911; rs36167516; rs34328687; rs34050557; rs4400483; rs10811016; rs13287162; rs13286127; rs34816420; rs7018618; rs34436773; rs41302220; rs7023090; rs34253990; rs2779122; rs28796737; rs36195957; rs13286678; rs12337535; rs34005652; rs34330935; rs13300504; rs7036374; rs35932920; rs10570129; rs5896791; rs3837242; rs9407930; rs733148; rs12340914; rs34781772; rs13299323; rs10963617; rs13290738; rs12342640; rs10963728; rs35544370; rs34619899; rs7021207; rs4636296; rs36058307; rs13302831; rs34220297; rs35733288; rs7039018; rs34097794; rs13296026; rs34692510; rs12345056; rs4295751; rs12684681; rs35418109; rs10963616; rs776787; rs34442889; rs34095656; rs11460867; rs35885690; rs16936912; rs10963677; rs34142086; rs13283592; rs34383159; rs10963705; rs13301966; rs12339412; rs13295267; rs35253110; rs7469878; rs13287437; rs13298928; rs36189694; rs13296183; rs33924965; rs1147796; rs35647604; rs36181847; rs36140539; rs11793105; rs34049116; rs34846596; rs33982024; rs34918407; rs34381763; rs11446181; rs13283440; rs13296717; rs35554258; rs7041646; rs34946727; rs34476081; rs10963706; rs10963632; rs13300153; rs13289970; rs35356159; rs10555563; rs776759; rs11506410; rs3860972; rs776786; rs4977506; rs36146200; rs10963619; rs36154944; rs34178821; rs34040817; rs35418018; rs35808221; rs13286754; rs33918828; rs35042945; rs10963721; rs12682798; rs35154592; rs34869167; rs5896798; rs4385562; rs9406754; rs944721; rs33996142; rs10811004; rs13283382; rs34965386; rs13289145; rs35382307; rs9650689; rs2779123; rs10963628; rs10557285; rs34798328; rs10963736; rs10963647; rs9695326; rs10963679; rs10963641; rs41268979; rs2507118; rs35177614; rs3802340; rs34077257; rs35418231; rs34196549; rs10963699; rs35770069; rs34862602; rs36112027; rs34157511; rs12346293; rs5896793; rs34531876; rs35371614; rs13298652; rs35559107; rs11313686; rs35978243; rs34630851; rs1891041; rs12342497; rs13286696; rs12342495; rs34301959; rs13285912; rs34454766; rs10645309; rs33916252; rs5896787; rs35053966; rs10963708; rs36154545; rs36006423; rs35538858; rs13300862; rs2487476; rs10963723; rs35926683; rs34983844; rs36175671; rs34312083; rs33950212; rs13302220; rs35339048; rs13286598; rs35568696; rs36035302; rs34436139; rs4287034; rs35629404; rs34284261; rs34821893; rs1332705; rs7874968; rs5896795; rs776792; rs12341996; rs41311420; rs35417806; rs10811017; rs35264977; rs34166830; rs35182657; rs34628447; rs13301604; rs10532151; rs13286493; rs34109507; rs34621079; rs2095101; rs9407932; rs10963656; rs7389813; rs34068102; rs35349026; rs35642330; rs13290564; rs34201579; rs9802884; rs35461401; rs35255030; rs36145980; rs13291526; rs34343707; rs34263425; rs13286871; rs5896790; rs35159088; rs34238776; rs35915496; rs12216898; rs7466375; rs35640170; rs35629128; rs36104735; rs34450429; rs35245238; rs484122; rs13285951; rs12005770; rs13288110; rs35093359; rs9407931; rs10963702; rs41433052; rs7847401; rs7041704; rs2185376; rs35305418; rs519115; rs512837; rs5896789; rs34466221; rs34498930; rs13294711; rs35319836; rs35591011; rs35043947; rs7030986; rs35850320; rs36207208; rs28811624; rs12344921; rs7038860; rs10673652; rs34979585; rs5896792; rs13298947; rs10963618; rs2184003; rs35996734; rs1999488; rs34824201; rs35669972; rs34185587; rs1341064; rs13300270; rs4588951; rs35101804; rs10963674; rs12342110; rs34795909; rs35812809; rs36084146; rs10963651; rs28580690; rs10963725; rs34430407; rs34716128; rs13286662; rs10963678; rs776774; rs16936960; rs10963730; rs28631522; rs34126908; rs12683814; rs35857771; rs35231922; rs9792511; rs17209283; rs35463792; rs7045856; rs2082579; rs34101030; rs12379267; rs2383080; rs35284183; rs10963700; rs28512474; rs36091514; rs2811803; rs34169826; rs776747; rs13297207; rs13296581; rs13291036; rs36158955; rs34806424; rs13292412; rs34641518; rs35334357; rs5013435; rs28744598; rs34093249; rs13294947; rs10963690; rs12342501; rs36185606; rs13291906; rs34440975; rs34558329; rs28660058; rs36171685; rs10963631; rs28802339; rs34391322; rs34470501; rs34069867; rs35557854; rs7029381; rs35153132; rs35420327; rs35364702; rs34081958; rs35743622; rs34966179; rs545786; rs13284579; rs34610864; rs11315484; rs2383074; rs7871056; rs11793072; rs10963715; rs13288808; rs2482968; rs11387371; rs10963653; rs36105430; rs12340667; rs7024835; rs7465902; rs35452459; rs13302184; rs13286679; rs10963697; rs34918884; rs13300791; rs13301985; rs34854828; rs34153311; rs12379557; rs34540271; rs35214924; rs28548145; rs35568743; rs534452; rs10653217; rs4457426; rs11460866; rs1930264; rs35471468; rs35196962; rs35664109; rs1856895; rs10963663; rs34587944; rs34867394; rs34217170; rs35691010; rs11278457; rs11793073; rs1083110; rs12682670; rs7024939; rs11418722; rs12348453; rs1889004; rs35732709; rs10963698; rs35986324; rs12554270; rs34361890; rs10544641; rs34038101; rs10644915; rs10963720; rs11506411; rs10963638; rs13288960; rs35582749; rs35511233; rs7872766; rs35116229; rs13292958; rs2225569; rs34023792; rs2487475; rs34630583; rs34234309; rs4977507; rs36181877; rs12003196; rs34514562; rs574314; rs28635605; rs34098829; rs1341068; rs12348263; rs12350602; rs34050702; rs5896799; rs36181409; rs35010109; rs34164687; rs2095102; rs34706021; rs34453171; rs34570847; rs41302063; rs12344258; rs35083940; rs10963722; rs35601420; rs36150798; rs1412674; rs5896794; rs41268977; rs35136150; rs35711586; rs9792675; rs7038433; rs34469008; rs11793012; rs35270230; rs13296027; rs9407926; rs13294944; rs35990368; rs4344171; rs7865199; rs4385563; rs35477457; rs36020134; rs35847846; rs548315; rs5896797; rs1832637; rs13301770; rs13301602; rs11339613; rs35899945; rs12380455; rs12683886; rs519878; rs10696982; rs1332710; rs34025313; rs13295553; rs12006403; rs35189980; rs34279293; rs1578428; rs34341152; rs35599040; rs2210501; rs1411151; rs7039052; rs5896788; rs7045855; rs28709272; rs34070469; rs13286585; rs16923418; rs41305317; rs35520713; rs12351354; rs34129180; rs5896796; rs10963709; rs35366579; rs16936920; rs7847776; rs13295832; rs34382100; rs34509994; rs35220169; rs5896786; rs2383078; rs12554532; rs4994335; rs12115542; rs41268975; rs7018593; rs34596088; rs35228238; rs28736826; rs36076173; rs13287108; rs13292276; rs28403986; rs12351319; rs7032837; rs10119856; rs13294903; rs34058021; rs35665436; rs12001313; rs35264941; rs4961658; rs12340707; rs34900718; rs13302136; rs35518030; rs16936915; rs35694929; rs7025364; rs4327937; rs35874115; rs35094886; rs34831037; rs34304159; rs36060882; rs4406499; rs10123481; rs10123802; rs10511656; rs10756965; rs10756966; rs10756967; rs10810972; rs10963613; rs10963738; rs1147794; rs12342476; rs12553779; rs1417036; rs1417037; rs1417641; rs1433816; rs16936735; rs16936745; rs17206286; rs1888067; rs1888068; rs1888069; rs1999174; rs2507117; rs3898100; rs476104; rs476196; rs476460; rs480814; rs487258; rs487882; rs507556; rs515375; rs532543; rs542826; rs563805; rs574090; rs574151; rs579517; rs580568; rs6475220; rs748108; rs7867766; rs944716; rs944717; rs954183

# Macromolecular_Interacting_Partner_20_General_References:
11805097; 12975309

# Macromolecular_Interacting_Partner_20_References:
1527055; 1557410; 2559078; 2777788

End of HMDB00024

Beginning of HMDB00026
# Accession_No:
HMDB00026

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 10:44:44

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ureidopropionic acid

# Description:
A breakdown product of pyrimidines.  Enzyme deficiencies in pyrimidine metabolism are associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil.

# Synonyms:
3-Ureido-propionate; 3-Ureidopropionate; 3-Ureidopropionic acid; Carbamoyl-b-Ala-OH; N-(aminocarbonyl)-'b-Alanine; N-(aminocarbonyl)-beta-Alanine; N-Carbamoyl-beta-alanine; Ureidopropionate; Ureidopropionic acid; beta-Ureidopropionate; beta-Ureidopropionic acid; Carbamoyl-beta-Ala-OH

# Chemical_IUPAC_Name:
3-carbamoylaminopropanoic acid

# Chemical_Formula:
C4H8N2O3

# Chemical_Structure:
tbl_chemical:::HMDB00026_ZOOM.png:::119283138154179312

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00026_THUMB.png:::119283137958936059

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid; urea

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Pantothenate and CoA biosynthesis; Component of Pyrimidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
132.05350

# Molecular_Weight_Avg:
132.11792

# Smiles_String_isomeric:
NC(=O)NCCC(O)=O

# Smiles_String_canonical:
NC(=O)NCCC(O)=O

# KEGG_Compound_ID:
C02642

# BioCyc_ID:
3-UREIDO-PROPIONATE

# PubChem_CID:
111

# PubChem_SID:
10322862; 11534299; 111024; 8148862; 210160; 2017; 8145171; 564993; 5179319; 8150463; 5621

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
40270

# Wikipedia_ID:
Not Available

# METLIN_ID:
5097

# Ref_ID:
11675655; 16513432; 16305582; 12798197; 2936452; 12386128

# ChEBI_ID:
18261

# CAS_Registry_Number:
462-88-4

# InChI:
InChI=1/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)

# Synthesis_Reference:
Journal of Fermentation Technology  (1978),  56(5),  492-8.

# Melting_Point:
170 oC

# Melting_Point_predicted:
37.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
20.9 mg/mL [BEILSTEIN]

# H2O_Solubility_Predicted:
52.7 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-0.98 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]; -1.34 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02642.mol:::1132723802109157706

# SDF_File_[Text]:
tbl_chemical:::HMDB00026.sdf:::119283137601371321

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00026.pdb:::119283137791447418

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_presat.png:::114711936715810941

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_presat.zip:::114711936717993213

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050123_P00_03_IS_1DP_Assigned.png:::114711936720049209

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204.png:::117520945313586096

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204.zip:::117520945320179055

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050123_P00_03_IS_2DHSQC_2204_Assigned.png:::117520945339588857

# Predicted_H_NMR_Spectrum:
tbl_chemical:::3-Ureidopropionic acid.gif:::1132732100015877713

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00026_peaks.txt:::1156309494538825963

# Predicted_C_NMR_Spectrum:
tbl_chemical:::3-Ureidopropionic acid_C.gif:::11327376604013278

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00026_peaks.txt:::1156310686369784435

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00026L.png:::117555261793792483; Medium Energy:tbl_ms:::HMDB00026M.png:::117555266909968250; High Energy:tbl_ms:::HMDB00026H.png:::117555270752521489

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	2.23 (1.48 - 2.81)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	16513432
Urine	0.88	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197
Urine	0.88	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	12798197


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Beta-Ureidopropionase (UP) Deficiency; Combined Uraciluria-Thyminuria

# Pathway_Names:
Pantothenate and CoA biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00770

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5814

# Metabolic_Enzyme_1_Name:
Dihydropyrimidinase

# Metabolic_Enzyme_1_Synonyms:
DHPase; Hydantoinase; DHP

# Metabolic_Enzyme_1_Gene_Name:
DPYS

# Metabolic_Enzyme_1_Protein_Sequence:
>Dihydropyrimidinase
MAAPSRLLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVL
PGGIDTHTHMQFPFMGSRSIDDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETWRSW
ADPKVCCDYSLHVAVTWWSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDLELYEAFS
RCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAV
NCPLYIVHVMSKSAAKVIADARRDGKVVYGEPIAASLGTDGTHYWNKEWHHAAHHVMGPP
LRPDPSTPDFLMNLLANDDLTTTGTDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIW
EKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDPKGTRTISAKTHH
QAVNFNIFEGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPRKPFAEYIYKRIKQRD
RTCTPTPVERAPYKGEVATLKSRVTKEDATAGTRKQAHP

# Metabolic_Enzyme_1_Number_of_Residues:
519

# Metabolic_Enzyme_1_Molecular_Weight:
56630

# Metabolic_Enzyme_1_Theoretical_pI:
7.28

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
5,6-dihydrouracil + H(2)O = 3- ureidopropanoate

# Metabolic_Enzyme_1_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_1_Reaction:
5,6-dihydrouracil + H2O = 3-ureidopropanoate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_1_Signals:
1-2

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.5.2.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1330236

# Metabolic_Enzyme_1_SwissProt_ID:
DPYS_HUMAN (Q14117)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DPYS

# Metabolic_Enzyme_1_Geneatlas_id:
DPYS

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3013

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_1_Gene_Sequence:
>1560 bp
ATGGCGGCGCCCTCGCGGCTCCTGATCCGCGGGGGTCGCGTGGTCAACGATGACTTCTCG
GAGGTGGCCGACGTGCTGGTGGAGGACGGCGTGGTGCGGGCACTCGGGCACGACCTGCTG
CCTCCCGGGGGCGCTCCTGCGGGGCTGCGGGTCCTCGACGCCGCCGGCAAGCTCGTCCTG
CCCGGAGGCATCGACACACACACGCACATGCAGTTCCCCTTCATGGGCTCGCGGTCCATC
GACGACTTCCACCAGGGCACCAAGGCTGCTCTCTCAGGAGGCACCACCATGATTATTGAT
TTCGCCATTCCTCAGAAAGGTGGCTCCCTCATTGAGGCCTTCGAGACCTGGCGAAGCTGG
GCTGATCCCAAAGTTTGCTGCGACTACAGCCTTCATGTGGCAGTGACGTGGTGGAGTGAC
CAGGTTAAAGAAGAAATGAAAATCCTTGTGCAAGATAAAGGTGTTAACTCTTTCAAGATG
TTTATGGCCTATAAAGATCTGTACATGGTGACAGACCTGGAGCTGTACGAAGCCTTCTCT
CGGTGCAAGGAAATTGGAGCAATTGCCCAGGTCCATGCGGAAAATGGAGACTTAATTGCA
GAGGGAGCAAAGAAGATGTTGGCTCTGGGGATAACAGGCCCTGAGGGCCACGAGCTGTGC
CGCCCAGAGGCAGTGGAGGCAGAGGCCACGCTGAGAGCCATCACCATAGCCAGCGCTGTG
AACTGTCCTCTCTACATTGTGCATGTGATGAGCAAGTCTGCAGCTAAGGTGATAGCGGAT
GCAAGGAGAGATGGGAAGGTGGTCTATGGTGAACCCATAGCAGCCAGTCTTGGCACAGAT
GGCACTCACTACTGGAATAAAGAATGGCACCATGCAGCCCACCATGTCATGGGTCCACCT
TTGCGACCAGACCCCTCAACACCCGACTTCCTCATGAATCTGTTGGCTAATGATGATCTA
ACCACAACAGGGACTGATAACTGCACTTTCAACACCTGCCAGAAAGCTCTTGGGAAGGAT
GATTTTACCAAGATCCCCAATGGGGTGAATGGTGTTGAAGATCGGATGTCCGTAATATGG
GAAAAAGGCGTGCATAGTGGTAAAATGGATGAAAACAGATTTGTGGCAGTTACCAGCACA
AATGCAGCCAAAATTTTTAATCTCTATCCAAGAAAAGGAAGAATAGCTGTAGGATCAGAT
GCTGACATTGTTATTTGGGACCCAAAAGGCACAAGGACTATCTCAGCAAAAACTCATCAT
CAGGCTGTTAACTTCAACATTTTCGAGGGCATGGTTTGCCACGGGGTGCCCCTTGTGACT
ATTTCAAGAGGCAAAGTGGTATATGAAGCCGGAGTGTTCAGTGTCACGGCAGGAGATGGG
AAGTTTATTCCTCGAAAACCATTTGCTGAATATATTTACAAACGAATAAAGCAGCGAGAC
CGGACTTGCACACCTACCCCTGTGGAGCGTGCACCCTATAAGGGAGAAGTCGCCACACTG
AAATCCAGAGTGACAAAAGAAGATGCCACAGCAGGGACCAGGAAACAGGCCCACCCCTGA


# Metabolic_Enzyme_1_GenBank_ID_Gene:
D78011

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q22

# Metabolic_Enzyme_1_SNPs:
rs7825427; rs2298840; rs35013010; rs2853149; rs2853161; rs2246815; rs2333874; rs2669435; rs2246650; rs2669432; rs870789; rs2853150; rs2853178; rs2853169; rs2853164; rs2669429; rs1317472; rs2669436; rs1317380; rs1319371; rs2333871; rs2251371; rs2853168; rs1325; rs2853158; rs2853155; rs2853160; rs13263121; rs11783979; rs2853151; rs7821992; rs2853181; rs6468929; rs3737535; rs6468928; rs6999483; rs3793358; rs7000266; rs1513025; rs6989588; rs4734106; rs4305867; rs6468924; rs7004911; rs2669438; rs6989484; rs7012764; rs2853170; rs1513026; rs2246827; rs6994920; rs4734793; rs2853154; rs6468927; rs11989338; rs11779762; rs2853167; rs3133279; rs2250601; rs3793354; rs2853157; rs3793356; rs2853176; rs11995044; rs10505058; rs2853180; rs17245950; rs6989353; rs4734794; rs7014456; rs2853159; rs2853174; rs16871364; rs7012566; rs2669434; rs3793355; rs12675680; rs2669425; rs6468926; rs1962267; rs12679642; rs12545205; rs6994791; rs2669431; rs3793352; rs3793357; rs6983974; rs2669421; rs11987822; rs3133278; rs2853175; rs2253336; rs7010772; rs2853173; rs3793351; rs2853172; rs2669420; rs13271902; rs2669427; rs2669426; rs16871363; rs16871365; rs3793361; rs13249169; rs10808391; rs1327; rs4236774; rs2853156; rs2669430; rs2246821; rs16892397; rs13256669; rs1317357; rs13276697; rs2669437; rs6998185; rs13282328; rs10110355; rs2254738; rs13264598; rs2669419; rs16871466; rs3793353; rs4734797; rs7014134; rs10103147; rs2280010; rs7816369; rs17834440; rs6984745; rs2669423; rs13272770; rs3133281; rs2333875; rs12548603; rs3838708; rs2853179; rs4734798; rs17245780; rs2669424; rs2669433; rs7830021; rs4734796; rs2251374; rs1355691; rs16871361; rs16892398; rs6997991; rs2959024; rs2853148; rs2959025; rs36027551; rs34895123; rs35670436; rs35371065; rs2959023; rs6468925; rs6981049; rs11291771; rs34363633; rs36043601; rs35130488; rs35179334; rs5893687; rs34804847; rs34835869; rs34900729; rs3039791; rs3133280; rs34353212; rs1962266; rs34752863; rs35698680; rs13282051; rs17245479; rs34714020; rs34101301; rs34571719; rs33942215; rs35916478; rs34084483; rs35633624; rs7844185; rs35400656; rs11323937; rs35787438; rs2669439; rs2333870; rs28571799; rs35879325; rs35854847; rs10680569; rs28465605; rs4282534; rs35034310; rs35294948; rs35514435; rs10662772; rs5893685; rs11988300; rs1849444; rs35035392; rs35556854; rs34744515; rs2333873; rs36048718; rs2298841; rs35513452; rs35953220; rs2175692; rs35758944; rs13258070; rs10086232; rs5893688; rs7462383; rs13270458; rs34960309; rs34272796; rs34765621; rs11323938; rs2853152; rs35148727; rs35796122; rs35852759; rs35907176; rs1044403; rs35549842; rs2853162; rs34531171; rs2853171; rs7008591; rs34183780; rs2853130; rs34505030; rs13250630; rs35237634; rs3793360; rs6984037; rs11781253; rs7001837; rs28541850; rs11388669; rs35012619; rs34256594; rs4281090; rs35378953; rs3838709; rs28410924; rs35450967; rs7008920; rs34793099; rs1319386; rs2333872; rs2669428; rs2853163; rs13253383; rs34867904; rs11325699; rs35082298; rs5893686; rs35144447; rs34793262; rs3793359; rs36003516; rs36075709; rs3763515; rs34184625; rs28407196; rs34513404; rs10101743; rs1105622; rs11779233; rs11782457; rs11997948; rs12541941; rs12543989; rs1316456; rs1317221; rs1355692; rs2669440; rs2853135; rs2853136; rs2853138; rs2853139; rs2853140; rs2853141; rs2853142; rs2853143; rs2853144; rs2853145; rs2942570; rs2959026; rs2959027; rs35349928; rs3750187; rs4734787; rs4734788; rs4734790; rs6992445

# Metabolic_Enzyme_1_General_References:
8973361; 9718352

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5815

# Metabolic_Enzyme_2_Name:
Beta-ureidopropionase

# Metabolic_Enzyme_2_Synonyms:
Beta-alanine synthase; N- carbamoyl-beta-alanine amidohydrolase; BUP-1

# Metabolic_Enzyme_2_Gene_Name:
UPB1

# Metabolic_Enzyme_2_Protein_Sequence:
>Betaureidopropionase
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPR
IVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQE
AWTMPFAFCTREKLPWTEFAE
SAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLW
NTAVVISNSGAVLGKTRKNHIPRVGDFNESTY
YMEGNLGHPVFQTQFGRIAVNICYGRH
HPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANH
CFTCAINRVGTEHFPN
EFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQV
NDVWN
FKMTGRYEMYARELAEAVKSNYSPTIVKE

# Metabolic_Enzyme_2_Number_of_Residues:
384

# Metabolic_Enzyme_2_Molecular_Weight:
43166

# Metabolic_Enzyme_2_Theoretical_pI:
6.51

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_2_Reaction:
N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.1.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
6288771

# Metabolic_Enzyme_2_SwissProt_ID:
BUP1_HUMAN (Q9UBR1)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UPB1

# Metabolic_Enzyme_2_Geneatlas_id:
UPB1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:16297

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1155 bp

ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC
CGACTTGCAGG
AAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGC
CCAGGGAAGCTTTCGAAGCTGC
CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTT
GAAGCAGCGGAGGAGCAGCTGAGACGACCCCGC
ATTGTGCACGTGGGGCTGGTTCAGAA
CAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCT
CTGCCCTTCATAGAC
GCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTT
CCAG
GAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTT
GCTGAG
TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCA
TGACATGGTGGTGGTGT
CTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGT
GGAATACAGCCGTGGTGATCTCCAATTC
CGGAGCAGTCCTGGGAAAGACCAGGAAAAAC
CACATCCCCAGAGTGGGTGATTTCAACGAGTCAACTTAC
TACATGGAGGGAAACCTGGG
CCACCCCGTGTTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCT
ACGGGCGGC
ACCACCCCCTCAACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCT
C
GGCCACGATAGGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCC
ATTGCCAATCAC
TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAA
CGAGTTTACCTCGGGAGATGGAA
AGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCT
CGAGCTATGTGGCAGCCCCTGACAGCAGCCGGAC
TCCTGGGCTGTCCCGTAGCCGGGAT
GGACTGCTAGTTGCTAAGCTCGACCTAAACCTCTGCCAGCAGGTG
AATGATGTCTGGAA
CTTCAAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCA
AGT
CCAACTACAGCCCCACCATCGTGAAAGAGTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF163312

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q11.2

# Metabolic_Enzyme_2_SNPs:
rs34110964; rs2232867; rs1314; rs2070474; rs2232866; rs140330; rs6004171; rs1892721; rs2232868; rs738814; rs1015011; rs140324; rs5760464; rs140338; rs6004175; rs5996713; rs762279; rs8142051; rs140335; rs3788372; rs12159862; rs3788369; rs140337; rs131455; rs2298384; rs5760455; rs131456; rs1015050; rs12628029; rs6004167; rs5760467; rs175766; rs5996712; rs140334; rs4414772; rs35270298; rs2298385; rs3788370; rs5751894; rs9612646; rs3788371; rs8141985; rs5751893; rs140331; rs8139394; rs11912222; rs5760466; rs7290860; rs5760459; rs11704820; rs16978612; rs140332; rs2232865; rs6004174; rs5751892; rs7289159; rs2070473; rs34035085; rs9620392; rs2232870; rs35916595; rs2070475; rs34595756; rs33939150; rs6004176; rs175767; rs9608293; rs13055831; rs5760465; rs5760457; rs34272823; rs34212925; rs11704528; rs140339; rs5760461; rs5751891; rs9620394; rs34817009; rs35770800; rs5760458; rs5844593; rs9624489; rs131454; rs10428056; rs10427702; rs6004172; rs5760460; rs7290073; rs140326; rs12170801; rs41446544; rs11306738; rs8139687; rs35821245; rs140329; rs11912437; rs11704936; rs28588566; rs9612641; rs12159402; rs9624487; rs5751890; rs5996709; rs28793636; rs35606558; rs34346301; rs5760463; rs12168497; rs35350082; rs6004168; rs140327; rs5996711; rs34804666; rs12166299; rs140325; rs13056366; rs12170842; rs140328; rs131452; rs6004173; rs8137394; rs9624485; rs9624488; rs34688005; rs9624486; rs9612637; rs12159199; rs9608291; rs140333; rs10427760; rs5996710; rs12169955; rs2232864; rs6004169; rs3765615; rs11350644; rs140336; rs3032747; rs34577100; rs13056367; rs9624484; rs6004170; rs2232869; rs9612640; rs28461476; rs7289603; rs5760462; rs131453; rs4049935; rs34276962; rs5760456; rs11913979; rs9612643; rs34916208; rs34067128; rs41302573; rs2232863; rs2232862; rs2232858; rs2232860; rs5751889; rs7289016; rs2232861; rs2232859; rs2232857; rs11090327; rs131460; rs140342; rs1543757; rs17004940; rs4346492; rs4558681; rs4820592; rs4822501; rs4822502; rs5760449; rs5760450; rs5760451; rs5760452; rs5760469; rs5996707; rs5996715; rs9612648

# Metabolic_Enzyme_2_General_References:
10542323; 11508704

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8498

# Macromolecular_Interacting_Partner_1_Name:
Dihydropyrimidinase-related protein 3

# Macromolecular_Interacting_Partner_1_Synonyms:
DRP-3; Unc-33-like phosphoprotein; ULIP protein; Collapsin response mediator protein 4; CRMP-4

# Macromolecular_Interacting_Partner_1_Gene_Name:
DPYSL3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydropyrimidinaserelated protein 3
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA
NGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY
EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE
LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI
TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE
RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV
SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK
RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSL
SGTQVDEGVRSASKRIVAPPGGRSNITSLS

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
570

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
61964

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.45

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_1_Specific_Function:
May regulate vesicle function in the growth cone

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_1_Signals:
Not Available

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1330242

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DPYL3_HUMAN (Q14195)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DPYSL3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:3015

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Cell projection; growth cone (By similarity). Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone (By similarity)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1713 bp
ATGTCCTACCAAGGCAAGAAGAACATCCCGCGGATCACGAGTGACCGTCTCCTTATCAAG
GGAGGCAGAATCGTCAATGATGATCAGTCCTTTTATGCTGATATTTACATGGAAGATGGC
TTAATAAAACAAATTGGAGACAATCTGATTGTTCCTGGAGGAGTGAAGACCATTGAAGCC
AATGGGAAGATGGTGATCCCTGGAGGCATCGATGTCCATACTCACTTCCAGATGCCATAT
AAGGGAATGACCACAGTAGATGACTTCTTCCAAGGGACAAAGGCGGCCTTAGCAGGTGGC
ACCACCATGATCATTGACCATGTGGTGCCTGAGCCTGAGTCCAGCCTGACTGAGGCCTAT
GAGAAATGGAGAGAGTGGGCTGATGGGAAGAGTTGCTGTGACTATGCCCTGCATGTGGAC
ATCACCCACTGGAATGACAGCGTCAAGCAGGAAGTGCAGAACCTCATCAAGGACAAAGGG
GTTAACTCCTTCATGGTTTATATGGCTTATAAGGATTTGTATCAAGTATCTAACACAGAG
CTCTATGAGATCTTCACCTGCCTGGGAGAGCTGGGGGCCATTGCTCAAGTTCATGCTGAG
AATGGGGATATCATTGCCCAGGAGCAAACCCGCATGTTGGAAATGGGGATAACTGGCCCA
GAAGGCCATGTACTGAGCAGGCCAGAAGAGCTGGAAGCTGAGGCTGTGTTCCGTGCCATC
ACCATTGCCAGCCAAACCAATTGCCCTCTCTACGTCACAAAGGTCATGAGCAAGAGTGCA
GCTGACCTCATCTCACAAGCCAGGAAAAAAGGAAATGTAGTCTTTGGTGAGCCCATCACT
GCCAGCCTCGGCATAGATGGAACCCATTATTGGAGCAAGAACTGGGCCAAGGCGGCTGCA
TTTGTGACATCCCCACCCCTGAGCCCTGACCCAACTACTCCGGACTACATCAACTCCTTG
CTGGCCAGCGGGGATCTGCAGCTATCTGGGAGTGCCCACTGCACCTTCAGCACTGCCCAG
AAAGCAATTGGGAAGGACAACTTCACAGCCATTCCTGAGGGCACCAATGGTGTGGAGGAG
CGGATGTCTGTCATCTGGGACAAGGCTGTGGCCACAGGGAAAATGGACGAAAACCAGTTC
GTGGCTGTGACAAGCACAAACGCTGCCAAGATCTTCAACCTGTATCCCCGCAAGGGAAGA
ATATCTGTGGGTTCTGACAGCGACCTCGTCATCTGGGATCCAGATGCTGTGAAGATCGTC
TCTGCCAAGAACCACCAGTCTGCGGCAGAGTACAACATCTTTGAAGGGATGGAGCTGCGC
GGGGCTCCTCTGGTTGTCATCTGCCAGGGCAAGATCATGCTGGAAGATGGCAACCTGCAC
GTGACCCAGGGGGCTGGCCGCTTCATACCCTGCAGCCCGTTCTCCGACTATGTCTACAAG
CGCATTAAAGCACGGAGGAAGATGGCAGACCTGCATGCCGTCCCAAGGGGCATGTACGAT
GGGCCTGTGTTTGACCTGACCACCACCCCCAAAGGTGGCACCCCCGCAGGCTCTGCTCGG
GGCTCTCCTACTCGGCCGAACCCACCTGTGAGGAATCTTCATCAGTCGGGATTTAGCCTG
TCAGGCACCCAAGTGGATGAGGGGGTTCGCTCAGCCAGCAAGCGCATCGTGGCCCCCCCA
GGCGGCCGTTCTAATATCACATCTCTGAGTTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
D78014

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q32

# Macromolecular_Interacting_Partner_1_SNPs:
rs2304044; rs10515587; rs3792837; rs17106709; rs1049171; rs3805533; rs11950394; rs13495; rs3749721; rs10065495; rs2288806; rs2304045; rs1432836; rs1432856; rs2288807; rs2163767; rs1432855; rs6886313; rs6877057; rs3792846; rs6892646; rs3792840; rs7732327; rs3213856; rs4705168; rs10079318; rs1432857; rs3792839; rs2288808; rs12515377; rs3805534; rs2288800; rs12657083; rs4705171; rs1432854; rs995976; rs7716469; rs7700678; rs6891468; rs2241696; rs7720075; rs7737514; rs2278381; rs7730192; rs7725771; rs6897123; rs2288804; rs12657176; rs1864961; rs10056132; rs1432853; rs11955404; rs7737495; rs12514302; rs12653560; rs7725904; rs3816013; rs17484444; rs11960053; rs11952079; rs17096661; rs11167990; rs17550470; rs1864962; rs6580463; rs17106725; rs3213857; rs17106726; rs17106713; rs6887761; rs12657809; rs3805538; rs2288803; rs3805536; rs11953018; rs12655364; rs17106698; rs3816012; rs7713047; rs1432852; rs2288805; rs7737670; rs17106658; rs4705169; rs17550902; rs7720384; rs11738709; rs10052013; rs6866421; rs1030664; rs2288802; rs11952440; rs6861479; rs11950421; rs10059782; rs4705172; rs3805535; rs2304046; rs10045916; rs6873278; rs11738683; rs3805539; rs3213858; rs6867744; rs17106761; rs17106743; rs12655492; rs12515730; rs17106723; rs3805546; rs9885115; rs12518292; rs17106691; rs3805544; rs17106683; rs3792844; rs6877045; rs17106688; rs7710577; rs17106716; rs13168262; rs1121657; rs13340333; rs11958380; rs17106746; rs17106686; rs3805545; rs6899104; rs1549915; rs17106689; rs3792841; rs3805543; rs17106682; rs2078128; rs11948890; rs3792845; rs3805540; rs17106701; rs2304043; rs17106690; rs3792843; rs2288809; rs17106679; rs6879557; rs3805542; rs10043932; rs891947; rs7700723; rs7728665; rs7714137; rs10064194; rs4642416; rs12513884; rs2895681; rs17106620; rs17106765; rs1803521; rs17853869; rs17853868; rs35891125; rs34332356; rs35381274; rs3805532; rs13002; rs35067518; rs1049161; rs6897295; rs1049378; rs1803520; rs34094540; rs13340338; rs7736691; rs36084531; rs10041249; rs3792842; rs36051157; rs34055088; rs28682302; rs35488909; rs10649833; rs13169665; rs4705170; rs10553344; rs2288801; rs41291407; rs35070418; rs34173457; rs11383280; rs34195078; rs41291405; rs35504293; rs11463979; rs35272843; rs34784063; rs6875205; rs1529689; rs34222194; rs10042993; rs3213855; rs10561142; rs34893040; rs2116776; rs9686079; rs35309287; rs34943516; rs35739037; rs5872019; rs2304047; rs13153310; rs41291409; rs35906615; rs35959663; rs10463275; rs35508159; rs34575049; rs3838662; rs11438535; rs4492158; rs13172668; rs3828640; rs10561140; rs34164945; rs13340366; rs3805537; rs3995474; rs35222650; rs10649832; rs11743139; rs28691592; rs34398961; rs36023679; rs35323408; rs6892354; rs9686962; rs36172751; rs13436842; rs35998040; rs35058477; rs10561141; rs34527322; rs35591026; rs34720144; rs10072652; rs10476887; rs10515586; rs11167989; rs1158445; rs11950567; rs12655505; rs1432837; rs1432838; rs17106606; rs17106607; rs17106610; rs1897563; rs729530; rs744585; rs7714240; rs972302

# Macromolecular_Interacting_Partner_1_General_References:
8973361; 9115293

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8721

# Macromolecular_Interacting_Partner_2_Name:
Dihydropyrimidinase-related protein 2

# Macromolecular_Interacting_Partner_2_Synonyms:
DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3

# Macromolecular_Interacting_Partner_2_Gene_Name:
DPYSL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Dihydropyrimidinaserelated protein 2
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEA
HSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAF
DQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQ
IYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAI
TIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAA
FVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEE
RMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI
SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYK
RIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFS
LSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
572

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
62294

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.33

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in neuronal growth cone collapse. Induces axon formation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
1244400

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DPYL2_HUMAN (Q16555)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DPYSL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3014

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasm (Potential)

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1719 bp
ATGTCTTATCAGGGGAAGAAAAATATTCCACGCATCACGAGCGATCGTCTTCTGATCAAA
GGAGGTAAAATTGTTAATGATGACCAGTCGTTCTATGCAGACATATACATGGAAGATGGG
TTGATCAAGCAAATAGGAGAAAATCTGATTGTGCCAGGAGGAGTGAAGACCATCGAGGCC
CACTCCCGGATGGTGATCCCCGGAGGAATTGACGTCCACACTCGTTTCCAGATGCCTGAT
CAGGGAATGACGTCTGCTGATGATTTCTTCCAAGGAACCAAGGCGGCCCTGGCTGGGGGA
ACCACTATGATCATTGACCACGTTGTTCCTGAGCCTGGGACAAGCCTGCTCGCTGCCTTT
GACCAGTGGAGGGAATGGGCCGACAGCAAGTCCTGCTGTGACTACTCTCTGCATGTGGAC
ATCAGCGAGTGGCATAAGGGCATCCAGGAGGAGATGGAAGCGCTTGTGAAGGATCACGGG
GTAAATTCCTTCCTCGTGTACATGGCTTTCAAAGATCGCTTCCAGCTAACGGATTGCCAG
ATTTATGAAGTACTGAGTGTGATCCGGGATATTGGCGCCATAGCCCAAGTCCACGCAGAA
AATGGCGACATCATTGCAGAGGAGCAGCAGAGGATCCTGGATCTGGGCATCACGGGCCCC
GAGGGACATGTGCTGAGCCGACCTGAGGAGGTCGAGGCCGAAGCCGTGAATCGTGCCATC
ACCATCGCCAACCAGACCAACTGCCCGCTGTATATCACCAAGGTGATGAGCAAAAGCTCT
GCTGAGGTCATCGCCCAGGCACGGAAGAAGGGAACTGTGGTGTATGGCGAGCCCATCACT
GCCAGCTTGGGAACGGACGGCTCCCATTACTGGAGCAAGAACTGGGCCAAGGCTGCTGCC
TTTGTCACCTCCCCACCCTTGAGCCCTGATCCAACCACTCCAGACTTTCTCAACTCCTTG
CTGTCCTGTGGAGACCTCCAGGTCACGGGCAGTGCCCATTGCACGTTTAACACTGCCCAG
AAGGCTGTAGGAAAGGACAACTTCACCCTGATTCCGGAGGGCACCAATGGCACTGAGGAG
CGGATGTCCGTCATCTGGGACAAGGCTGTGGTCACTGGGAAGATGGATGAGAACCAGTTT
GTGGCTGTGACCAGCACCAATGCAGCCAAAGTCTTCAACCTTTACCCCCGGAAAGGCCGC
ATTGCTGTGGGATCCGATGCCGACCTGGTCATCTGGGACCCCGACAGCGTTAAAACCATC
TCTGCCAAGACACACAACAGCTCTCTCGAGTACAACATCTTTGAAGGCATGGAGTGCCGC
GGCTCCCCACTGGTGGTCATCAGCCAGGGGAAGATTGTCCTGGAGGACGGCACCCTGCAT
GTCACCGAAGGCTCTGGACGCTACATTCCCCGGAAGCCCTTCCCTGATTTTGTTTACAAG
CGTATCAAGGCAAGGAGCAGGCTGGCTGAGCTGAGAGGGGTTCCTCGTGGCCTGTATGAC
GGACCCGTGTGTGAAGTGTCTGTGACGCCCAAGACAGTCACTCCAGCCTCCTCGGCCAAG
ACGTCTCCTGCCAAGCAGCAGGCCCCACCTGTCCGGAACCTGCACCAGTCTGGATTCAGT
TTGTCTGGTGCTCAGATTGATGACAACATTCCCCGCCGCACCACCCAGCGTATCGTGGCG
CCCCCCGGTGGCCGTGCCAACATCACCAGCCTGGGCTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
U17279

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_2_Locus:
8p22-p21

# Macromolecular_Interacting_Partner_2_SNPs:
rs2289593; rs327222; rs11786691; rs708621; rs920633; rs11863; rs17666; rs1058332; rs10495; rs17055646; rs3739219; rs17055641; rs10042; rs327215; rs2585459; rs1992472; rs1972921; rs327225; rs894509; rs327224; rs749936; rs448872; rs930470; rs385351; rs920697; rs1867042; rs327218; rs388047; rs327234; rs1561818; rs6992095; rs452787; rs1662248; rs451164; rs327226; rs11135950; rs6557933; rs327233; rs7825468; rs327221; rs6557930; rs11135951; rs4872457; rs13271910; rs398008; rs7004868; rs2034040; rs7829347; rs7841384; rs2289592; rs10088957; rs376954; rs6557931; rs7834325; rs384908; rs7835006; rs6557929; rs7832234; rs182748; rs6988996; rs920632; rs2584187; rs408753; rs7011131; rs6990931; rs12234932; rs4733048; rs749937; rs327223; rs920631; rs327230; rs7820433; rs327232; rs7840494; rs4733044; rs5022821; rs9644116; rs11995227; rs17322303; rs7812694; rs753508; rs327229; rs17322324; rs6557927; rs12678418; rs429591; rs17055516; rs17055593; rs11775462; rs17322275; rs17321828; rs12541748; rs4733033; rs11782869; rs11775497; rs17055515; rs999772; rs13277175; rs17322640; rs6557928; rs12677999; rs749935; rs9644117; rs4478581; rs17322528; rs4733013; rs327237; rs17322366; rs11776975; rs11775862; rs17055486; rs11774146; rs17405591; rs10093591; rs11776801; rs5029306; rs327227; rs7001738; rs1442336; rs327217; rs11780026; rs9644118; rs17406372; rs17055585; rs17405668; rs12550663; rs2585457; rs7832576; rs12677981; rs13250931; rs4076071; rs5022822; rs13249892; rs753509; rs429787; rs7818193; rs11778165; rs2083739; rs4732714; rs415524; rs17055546; rs11783896; rs12541952; rs17055500; rs12549410; rs403185; rs11775967; rs17055504; rs2120049; rs17055487; rs11775859; rs12546827; rs12546828; rs1808892; rs17322408; rs17321041; rs17055489; rs327228; rs11781865; rs12545134; rs327216; rs17322051; rs11780034; rs17088245; rs17419937; rs11990271; rs379266; rs17055482; rs17055494; rs7845756; rs7816762; rs17055502; rs17055605; rs2585458; rs10441614; rs7015088; rs17055514; rs7460917; rs327236; rs7008546; rs17055492; rs11780147; rs2322130; rs11784967; rs11781198; rs7009085; rs17055537; rs17055582; rs17055480; rs327214; rs327235; rs17055521; rs13249543; rs6557932; rs17055536; rs13260473; rs371255; rs3808564; rs6988457; rs6557926; rs17055491; rs11995685; rs6998628; rs6983262; rs7827731; rs7828056; rs2585456; rs445678; rs400181; rs367948; rs35621323; rs4733059; rs34588307; rs1803519; rs35258691; rs11527; rs34335048; rs17055639; rs3837184; rs1058457; rs41276289; rs34673092; rs35314544; rs1058333; rs1058313; rs11399423; rs35690946; rs28470992; rs34792838; rs34382438; rs6982026; rs390323; rs41276287; rs41276285; rs399788; rs34226529; rs34238466; rs920630; rs167855; rs34978863; rs28649929; rs34204302; rs2584183; rs35446474; rs3074034; rs34051886; rs35134585; rs34375962; rs10691983; rs35587383; rs2584182; rs35321818; rs11427313; rs35493897; rs920695; rs11400209; rs10584379; rs35273847; rs34633365; rs13262574; rs11998448; rs35225449; rs35476823; rs35253282; rs7010042; rs13248890; rs2584184; rs2120048; rs10556349; rs28889579; rs35219984; rs7015859; rs28750171; rs13276391; rs3074029; rs35474814; rs35226523; rs327213; rs34151191; rs7828110; rs33993906; rs11399087; rs11786298; rs11384905; rs3926189; rs12542360; rs36063450; rs7002026; rs17055594; rs327220; rs34880068; rs36110958; rs3779913; rs34241661; rs35006006; rs35117658; rs327231; rs10690987; rs35491396; rs33963820; rs36177037; rs4055147; rs11383598; rs35692875; rs28498128; rs11287159; rs1442337; rs34321710; rs7017875; rs35004176; rs35696405; rs4733051; rs7014178; rs2584185; rs35346128; rs35539107; rs34007808; rs7820494; rs35258351; rs35498265; rs11427312; rs35717375; rs10690986; rs11357827; rs35866474; rs35153261; rs41432246; rs7821827; rs378278; rs11285674; rs35363743; rs1966766; rs11355802; rs10606826; rs431246; rs3840708; rs17088240; rs11774816; rs11778187; rs11784283; rs11786284; rs11993953; rs12155555; rs13249662; rs13258612; rs13259621; rs13275466; rs17055673; rs17088247; rs17088251; rs17320101; rs17320156; rs17330335; rs2584188; rs2585455; rs364508; rs380423; rs401004; rs408157; rs418624; rs424422; rs429020; rs431217; rs442103; rs6557935; rs6987195; rs6987220; rs7827953; rs7831883; rs7842128; rs7845740; rs894330; rs920696; rs9644119

# Macromolecular_Interacting_Partner_2_General_References:
7637782; 8973361; 10574455; 10757975

# Macromolecular_Interacting_Partner_2_References:
Not Available

End of HMDB00026

Beginning of HMDB00027
# Accession_No:
HMDB00027

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 16:13:55

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Tetrahydrobiopterin

# Description:
Tetrahydrobiopterin or BH4 is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase. A defect in BH4 production and/or a defect in the enzyme dihydropteridine reductase (DHPR) causes phenylketonuria type IV, as well as dopa-responsive dystonias. -- Wikipedia.  

# Synonyms:
(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol; 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-Pteridinone; 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; 5,6,7,8-Tetrahydrobiopterin; 5,6,7,8-erythro-tetrahydrobiopterin; 5,6,7,8-tetra-H-biopterin; L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon; Tetrahydrobiopterin; tetra-H-biopterin; tetra-hydro-biopterin

# Chemical_IUPAC_Name:
2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-1H-pteridin-4-one

# Chemical_Formula:
C9H15N5O3

# Chemical_Structure:
tbl_chemical:::HMDB00027_ZOOM.png:::119283139231966374

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00027_THUMB.png:::119283139033785907

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins; Pterins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; 1,2-diol; 1,2-aminoalcohol; primary amine; primary aromatic amine; secondary amine; secondary aliphatic/aromatic amine (alkylarylamine); oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Enzyme co-factor; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Tryptophan metabolism; Component of Tyrosine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
241.11749

# Molecular_Weight_Avg:
241.24710

# Smiles_String_isomeric:
CC(O)C(O)C1CNC2=C(N1)C(=O)NC(N)=N2

# Smiles_String_canonical:
CC(O)C(O)C1CNC2=C(N1)C(=O)NC(N)=N2

# KEGG_Compound_ID:
C00272

# BioCyc_ID:
TETRA-H-BIOPTERIN

# PubChem_CID:
1125

# PubChem_SID:
3570; 5642916; 7365597; 8150986; 207223; 3210; 8143160

# OMIM_ID:
126060; 182125; 233910; 261630; 261640; 264070

# Metagene_ID:
Not Available

# BiGG_ID:
34464

# Wikipedia_ID:
Tetrahydrobiopterin

# METLIN_ID:
5098

# Ref_ID:
11573638; 14500751; 3536512; 11416883; 12891653; 932231; 11168813; 3939528; 16165391; 12971421; 7869898; 16033258; 3888618; 9667588; 6139056; 11486900

# ChEBI_ID:
15372

# CAS_Registry_Number:
17528-72-2

# InChI:
InChI=1/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)

# Synthesis_Reference:
Not Available

# Melting_Point:
250-255 oC (hydrochloride salt)

# Melting_Point_predicted:
132.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
2.03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.82 [Predicted by ALOGPS]; -1.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00272.mol:::1132723802187504536

# SDF_File_[Text]:
tbl_chemical:::HMDB00027.sdf:::119283138562730381

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00027.pdb:::119283138866196305

# PDB_ID:
1DF1

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1DF1.txt:::113272089896859924

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::5,6,7,8-Tetrahydrobiopterin.gif:::1132732100078758123

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00027_peaks.txt:::1156309495564847060

# Predicted_C_NMR_Spectrum:
tbl_chemical:::5,6,7,8-Tetrahydrobiopterin_C.gif:::1132737660522595907

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00027_peaks.txt:::1156310687395293200

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm (Predicted from LogP); nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	2 (0-4)	uM	Adult:>18_yrs_old	Both	Normal	11573638


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	14400.0	umol/L	Newborn:0-30_days_old	Both	Seizures	7869898


# Associated_Disorders:
Biopterin Deficiency; Neuroblastoma; Phenylketonuria III; Pheochromocytoma; Seizures; Septic Shock

# Pathway_Names:
Folate biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00790

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5711

# Metabolic_Enzyme_1_Name:
Tryptophan 5-hydroxylase 2

# Metabolic_Enzyme_1_Synonyms:
Tryptophan 5-monooxygenase 2; Neuronal tryptophan hydroxylase

# Metabolic_Enzyme_1_Gene_Name:
TPH2

# Metabolic_Enzyme_1_Protein_Sequence:
>Tryptophan 5hydroxylase 2
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI

# Metabolic_Enzyme_1_Number_of_Residues:
490

# Metabolic_Enzyme_1_Molecular_Weight:
56057

# Metabolic_Enzyme_1_Theoretical_pI:
6.36

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tryptophan 5-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  neurotransmitter metabolism
Process:  neurotransmitter biosynthesis
Process:  serotonin biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
L-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_1_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_1_Reaction:
L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.16.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
27497159

# Metabolic_Enzyme_1_SwissProt_ID:
TPH2_HUMAN (Q8IWU9)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
TPH2

# Metabolic_Enzyme_1_Geneatlas_id:
TPH2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20692

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1473 bp
ATGCAGCCAGCAATGATGATGTTTTCCAGTAAATACTGGGCACGGAGAGGGTTTTCCCTG
GATTCAGCAGTGCCCGAAGAGCATCAGCTACTTGGCAGCTCAACACTAAATAAACCTAAC
TCTGGCAAAAATGACGACAAAGGCAACAAGGGAAGCAGCAAACGTGAAGCTGCTACCGAA
AGTGGCAAGACAGCAGTTGTTTTCTCCTTGAAGAATGAAGTTGGTGGATTGGTAAAAGCA
CTGAGGCTCTTTCAGGAAAAACGTGTCAACATGGTTCATATTGAATCCAGGAAATCTCGG
CGAAGAAGTTCTGAGGTTGAAATCTTTGTGGACTGTGAGTGTGGGAAAACAGAATTCAAT
GAGCTCATTCAGTTGCTGAAATTTCAAACCACTATTGTGACGCTGAATCCTCCAGAGAAC
ATTTGGACAGAGGAAGAAGAGCTAGAGGATGTGCCCTGGTTCCCTCGGAAGATCTCTGAG
TTAGACAAATGCTCTCACAGAGTTCTCATGTATGGTTCTGAGCTTGATGCTGACCACCCA
GGATTTAAGGACAATGTCTATCGACAGAGAAGAAAGTATTTTGTGGATGTGGCCATGGGT
TATAAATATGGTCAGCCCATTCCCAGGGTGGAGTATACTGAAGAAGAAACTAAAACTTGG
GGTGTTGTATTCCGGGAGCTCTCCAAACTCTATCCCACTCATGCTTGCCGAGAGTATTTG
AAAAACTTCCCTCTGCTGACTAAATACTGTGGCTACAGAGAGGACAATGTGCCTCAACTC
GAAGATGTCTCCATGTTTCTGAAAGAAAGGTCTGGCTTCACGGTGAGGCCGGTGGCTGGA
TACCTGAGCCCACGAGACTTTCTGGCAGGACTGGCCTACAGAGTGTTCCACTGTACCCAG
TACATCCGGCATGGCTCAGATCCCCTCTACACCCCAGAACCAGACACATGCCATGAACTC
TTGGGACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGT
CTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTC
ACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTC
CTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTT
GACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTT
GTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACC
CGTCCCTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACC
AGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCT
TTAAACAAAATGAACCAATATCTGGGGATTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AY098914

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q21.1

# Metabolic_Enzyme_1_SNPs:
rs17110563; rs4290270; rs7305115; rs17110747; rs1386493; rs2129575; rs1386494; rs2220330; rs1843809; rs1386495; rs1487284; rs1352251; rs1386497; rs1007023; rs1386488; rs990234; rs1386496; rs1843812; rs1352250; rs7310090; rs4760747; rs4760750; rs1473473; rs1386483; rs7963720; rs6582080; rs6582073; rs10748187; rs1487278; rs6582078; rs12322900; rs4760754; rs6582074; rs1386489; rs1386486; rs4641528; rs10748186; rs10879352; rs10748185; rs1487279; rs10879345; rs7954332; rs10879348; rs1386482; rs3903502; rs4430554; rs2200579; rs1386485; rs4760817; rs7295981; rs11179039; rs10879350; rs1386492; rs7979770; rs10784947; rs7978692; rs10748188; rs7978482; rs9325202; rs6582081; rs10879354; rs4760816; rs7299582; rs12230512; rs4488237; rs11834114; rs10879351; rs7307319; rs7315855; rs4760815; rs10879355; rs12231731; rs11179018; rs1487280; rs1487276; rs4641527; rs11179049; rs11179001; rs10879357; rs4565946; rs7967686; rs1386490; rs11179065; rs10506646; rs10506647; rs10748190; rs2368049; rs6582077; rs11178999; rs17722134; rs10784944; rs10784942; rs11179002; rs4760748; rs1532008; rs12319219; rs11615016; rs7300490; rs4469933; rs11830353; rs11179023; rs4760753; rs4760818; rs11179051; rs7969114; rs11179047; rs11179050; rs10784941; rs10506645; rs10506648; rs1386491; rs10879358; rs12311278; rs11830135; rs2046582; rs1843811; rs7964252; rs10879344; rs7968346; rs7300641; rs10879353; rs10784943; rs11179066; rs17110540; rs12301662; rs11179027; rs4474484; rs7309686; rs10748189; rs11833554; rs4760749; rs10506644; rs1843810; rs11179003; rs11179033; rs17110536; rs7967586; rs7963226; rs7955501; rs10879346; rs11179052; rs11179000; rs11831550; rs17110627; rs1487281; rs1386498; rs2171363; rs4760755; rs12229394; rs1487275; rs17110690; rs12231341; rs11834097; rs1023990; rs12231356; rs7954568; rs11179044; rs7134722; rs11830147; rs7954758; rs11179063; rs10879347; rs11179056; rs11179032; rs11179007; rs11179046; rs4453277; rs4760820; rs2171364; rs11179064; rs17110566; rs10879349; rs11179017; rs17110477; rs7299528; rs7487961; rs17110741; rs4362185; rs11179031; rs17110532; rs4573728; rs10784946; rs12231408; rs11179041; rs10784945; rs6582076; rs12228278; rs4503586; rs17110507; rs7139179; rs990235; rs4362186; rs6582075; rs17110668; rs7967568; rs4573729; rs10879359; rs11179034; rs12228879; rs11179048; rs7962607; rs11179024; rs11179008; rs17110467; rs7954105; rs4760814; rs7977183; rs2171365; rs17840794; rs1017933; rs4341581; rs4531512; rs11835828; rs2367899; rs11179058; rs11179059; rs11179020; rs6582079; rs6582072; rs7954142; rs12321434; rs17110489; rs7139195; rs11179015; rs4760751; rs11179043; rs11179022; rs12230254; rs17110472; rs7300445; rs11179004; rs11179038; rs11179045; rs4570625; rs7963717; rs7963803; rs11178996; rs34115267; rs7488262; rs2887147; rs41317132; rs2887148; rs41317122; rs41317118; rs41317116; rs11178998; rs12813452; rs2632292; rs35993964; rs36102830; rs34100617; rs12831769; rs7350608; rs1487286; rs12312472; rs2046583; rs12831265; rs11179060; rs2632287; rs41265611; rs35367496; rs2450502; rs12831272; rs12314642; rs2008391; rs5799059; rs35958105; rs1487273; rs2450501; rs35035554; rs1023989; rs10716615; rs12302940; rs11179012; rs11179037; rs41317136; rs2468914; rs7304392; rs12814228; rs12296809; rs11179025; rs2468917; rs11179019; rs34378240; rs7298203; rs7958320; rs2468920; rs7315349; rs35794144; rs11179055; rs12812037; rs12228469; rs9738929; rs2632290; rs34599234; rs2632293; rs41317128; rs11829559; rs34046675; rs11179054; rs35124331; rs11316791; rs2129576; rs2632288; rs35446623; rs2732333; rs1005691; rs10550878; rs11179011; rs11330029; rs5799058; rs12814265; rs5799061; rs2450504; rs35402781; rs12821195; rs36018735; rs2931544; rs34856767; rs2632294; rs12228247; rs11385244; rs11462521; rs763541; rs34763587; rs34121208; rs34723664; rs2632291; rs4503587; rs17840795; rs34428545; rs35425528; rs35583269; rs12812852; rs2468922; rs2732329; rs34488392; rs11179036; rs41317124; rs4760752; rs11179053; rs34679573; rs5799057; rs2200580; rs35694485; rs35463818; rs11179014; rs35205883; rs41317134; rs35597435; rs1487274; rs2468916; rs12821199; rs6582082; rs7968971; rs34540665; rs11179016; rs12424793; rs11179062; rs2632289; rs12367924; rs2220329; rs34303765; rs41317120; rs5799060; rs10574609; rs35440773; rs12301107; rs12829796; rs2450503; rs36090475; rs12812015; rs11830809; rs12812513; rs2931545; rs11179010; rs11179005; rs12831748; rs2468921; rs2468919; rs35445127; rs34487536; rs2468915; rs2046584; rs9668942; rs34206155; rs35740727; rs12811510; rs11179009; rs11179013; rs36017866; rs34790266; rs1386484; rs41317126; rs2129574; rs34517220; rs2468918; rs11179029; rs34354367; rs34133267; rs12812196; rs34334884; rs34169600; rs41317130; rs11179057; rs35633991; rs11179006; rs10578769; rs11179061; rs11179028; rs12230557; rs41317114; rs41269717; rs41269713; rs11178997; rs41269707; rs41269715; rs41269709; rs41269711; rs41265615; rs41269719; rs11178991; rs11178992; rs11178993; rs11179068; rs12229424; rs12309337; rs12580063; rs1386487; rs17110443; rs17110451; rs17110459; rs1872824; rs2632286; rs2732330; rs2732331; rs2732332; rs3935748; rs4131348; rs4145228; rs4448731; rs4760813; rs6582071; rs6582083; rs7296397; rs7296838; rs7309440; rs7969998; rs901597

# Metabolic_Enzyme_1_General_References:
12511643

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5816

# Metabolic_Enzyme_2_Name:
Dihydropteridine reductase

# Metabolic_Enzyme_2_Synonyms:
HDHPR; Quinoid dihydropteridine reductase

# Metabolic_Enzyme_2_Gene_Name:
QDPR

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydropteridine reductase
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF

# Metabolic_Enzyme_2_Number_of_Residues:
244

# Metabolic_Enzyme_2_Molecular_Weight:
25790

# Metabolic_Enzyme_2_Theoretical_pI:
7.45

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases

# Metabolic_Enzyme_2_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_2_Reaction:
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.1.34

# Metabolic_Enzyme_2_GenBank_ID_Protein:
30819

# Metabolic_Enzyme_2_SwissProt_ID:
DHPR_HUMAN (P09417)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
QDPR

# Metabolic_Enzyme_2_Geneatlas_id:
QDPR

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9752

# Metabolic_Enzyme_2_PDB_ID:
1HDR

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>735 bp
ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC
GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT
GATGTGGTGGAGAATGAAGAGGCCAGCGCTACGATCATTGTTAAAATGACAGACTCGTTC
ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG
GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC
TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT
CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC
CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC
TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG
CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC
TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC
CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC
CCAGCATATTTTTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X04882

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4p15.31

# Metabolic_Enzyme_2_SNPs:
rs3733570; rs12645938; rs3733569; rs2597775; rs1031327; rs1031326; rs1049581; rs1049600; rs699459; rs1049601; rs10604; rs699460; rs1049582; rs2597778; rs10008024; rs10006709; rs1411985; rs2315248; rs12644621; rs10939729; rs2518609; rs3822231; rs3733575; rs12512471; rs10004095; rs4698601; rs6819744; rs6827193; rs7660043; rs2518613; rs2518610; rs2597770; rs11722315; rs744729; rs2518616; rs731437; rs17458406; rs2253130; rs3796809; rs10013112; rs3094278; rs2252995; rs7696913; rs12647753; rs2518618; rs2597768; rs744731; rs2518615; rs7662925; rs9998021; rs10516314; rs10000532; rs10011038; rs2244804; rs12644449; rs12498807; rs9995626; rs3775922; rs10084995; rs11946133; rs3733572; rs2597777; rs12511229; rs13121927; rs3733573; rs28418409; rs10939724; rs10939725; rs7670743; rs3775921; rs3733574; rs3822234; rs2597767; rs744730; rs7676618; rs10030250; rs10020171; rs2518624; rs2518625; rs2597766; rs6449303; rs6811303; rs2244788; rs2597765; rs2305316; rs2597764; rs2597781; rs2518623; rs1031325; rs2315246; rs2315247; rs12512495; rs11556809; rs2518608; rs11556811; rs41268391; rs1803486; rs35601449; rs9995723; rs28407193; rs2305315; rs2518614; rs6841929; rs34374888; rs35810383; rs2597769; rs2518611; rs2597771; rs10027962; rs10031275; rs3733571; rs28678909; rs2597774; rs28587968; rs28465580; rs10008333; rs41268393; rs28547068; rs7436922; rs28394602; rs36202813; rs28548890; rs4083729; rs10028346; rs34235865; rs28391487; rs10050325; rs5856425; rs35863325; rs28375535; rs34319569; rs34528211; rs11736337; rs3822233; rs28435289; rs2597773; rs2518612; rs35068359; rs12498326; rs34914923; rs34012502; rs13137081; rs35469730; rs34100425; rs35826618; rs28449900; rs10632253; rs12647416; rs28580482; rs34858847; rs35314811; rs2597776; rs10598892; rs3217604; rs2597779; rs28621908; rs5856426; rs11351628; rs10022501; rs28425622; rs7685575; rs2518622; rs2597772; rs35054011; rs34311884; rs7660847; rs36094070; rs35198436; rs3066734; rs2597780; rs11935131; rs6823650; rs7672603; rs7694662; rs2518606; rs11556808; rs2597782; rs2518607; rs10026004; rs11733530; rs12499694; rs13128422; rs13128427; rs13128864; rs13131273; rs13138275; rs1473352; rs1551091; rs1551092; rs16895134; rs16895143; rs1868733; rs1868734; rs1868735; rs2122571; rs2247952; rs2518603; rs2518604; rs2518605; rs2518626; rs2597752; rs2597753; rs2597754; rs2597755; rs2597756; rs2597757; rs2597758; rs2597783; rs2597784; rs2597786; rs2697688; rs2697689; rs4698189; rs4698599; rs4698603; rs6817052; rs6835304; rs7661303

# Metabolic_Enzyme_2_General_References:
3031582; 3033643; 9744478; 8262916; 7627180; 8326489; 2116088; 10408783; 11153907

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5505

# Metabolic_Enzyme_3_Name:
Tyrosine 3-monooxygenase

# Metabolic_Enzyme_3_Synonyms:
Tyrosine 3-hydroxylase; TH

# Metabolic_Enzyme_3_Gene_Name:
TH

# Metabolic_Enzyme_3_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Metabolic_Enzyme_3_Number_of_Residues:
528

# Metabolic_Enzyme_3_Molecular_Weight:
58525

# Metabolic_Enzyme_3_Theoretical_pI:
6.25

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Metabolic_Enzyme_3_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_3_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00351:Biopterin_H

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.16.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
37127

# Metabolic_Enzyme_3_SwissProt_ID:
TY3H_HUMAN (P07101)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TH

# Metabolic_Enzyme_3_Geneatlas_id:
TH

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11782

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Y00414

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p15.5

# Metabolic_Enzyme_3_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Metabolic_Enzyme_3_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5673

# Metabolic_Enzyme_4_Name:
Sepiapterin reductase

# Metabolic_Enzyme_4_Synonyms:
SPR

# Metabolic_Enzyme_4_Gene_Name:
SPR

# Metabolic_Enzyme_4_Protein_Sequence:
>Sepiapterin reductase
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK

# Metabolic_Enzyme_4_Number_of_Residues:
261

# Metabolic_Enzyme_4_Molecular_Weight:
28049

# Metabolic_Enzyme_4_Theoretical_pI:
8.19

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  sepiapterin reductase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin

# Metabolic_Enzyme_4_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_4_Reaction:
7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.1.1.153

# Metabolic_Enzyme_4_GenBank_ID_Protein:
338021

# Metabolic_Enzyme_4_SwissProt_ID:
SPRE_HUMAN (P35270)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SPR

# Metabolic_Enzyme_4_Geneatlas_id:
SPR

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11257

# Metabolic_Enzyme_4_PDB_ID:
1Z6Z

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>786 bp
ATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGC
CGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGC
GCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGC
CTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTC
GGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAAC
GCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTG
AACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAG
GCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCC
CTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTG
TTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCT
CTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAA
GGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAA
CTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGAC
AAATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M76231

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2p14-p12

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
1883349; 8440319; 11825621

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5709

# Metabolic_Enzyme_5_Name:
Tryptophan 5-hydroxylase 1

# Metabolic_Enzyme_5_Synonyms:
Tryptophan 5-monooxygenase 1

# Metabolic_Enzyme_5_Gene_Name:
TPH1

# Metabolic_Enzyme_5_Protein_Sequence:
>Tryptophan 5hydroxylase 1
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI

# Metabolic_Enzyme_5_Number_of_Residues:
444

# Metabolic_Enzyme_5_Molecular_Weight:
50986

# Metabolic_Enzyme_5_Theoretical_pI:
7.23

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tryptophan 5-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  neurotransmitter metabolism
Process:  neurotransmitter biosynthesis
Process:  serotonin biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-tryptophan + tetrahydrobiopterin + O(2) = 5- hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_5_Pathway:
map00380  Tryptophan metabolism

# Metabolic_Enzyme_5_Reaction:
L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.16.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
37955

# Metabolic_Enzyme_5_SwissProt_ID:
TPH1_HUMAN (P17752)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
TPH1

# Metabolic_Enzyme_5_Geneatlas_id:
TPH1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12008

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Not Available

# Metabolic_Enzyme_5_Gene_Sequence:
>1335 bp
ATGATTGAAGACAATAAGGAGAACAAAGACCATTCCTTAGAAAGGGGAAGAGCAAGTCTC
ATTTTTTCCTTAAAGAATGAAGTTGGAGGACTTATAAAAGCCCTGAAAATCTTTCAGGAG
AAGCATGTGAATCTGTTACATATCGAGTCCCGAAAATCAAAAAGAAGAAACTCAGAATTT
GAGATTTTTGTTGACTGTGACATCAACAGAGAACAATTGAATGATATTTTTCATCTGCTG
AAGTCTCATACCAATGTTCTCTCTGTGAATCTACCAGATAATTTTACTTTGAAGGAAGAT
GGTATGGAAACTGTTCCTTGGTTTCCAAAGAAGATTTCTGACCTGGACCATTGTGCCAAC
AGAGTTCTGATGTATGGATCTGAACTAGATGCAGACCATCCTGGCTTCAAAGACAATGTC
TACCGTAAACGTCGAAAGTATTTTGCGGACTTGGCTATGAACTATAAACATGGAGACCCC
ATTCCAAAGGTTGAATTCACTGAAGAGGAGATTAAGACCTGGGGAACCGTATTCCAAGAG
CTCAACAAACTCTACCCAACCCATGCTTGCAGAGAGTATCTCAAAAACTTACCTTTGCTT
TCTAAATATTGTGGATATCGGGAGGATAATATCCCACAATTGGAAGATGTCTCCAACTTT
TTAAAAGAGCGTACAGGTTTTTCCATCCGTCCTGTGGCTGGTTACTTATCACCAAGAGAT
TTCTTATCAGGTTTAGCCTTTCGAGTTTTTCACTGCACTCAATATGTGAGACACAGTTCA
GATCCCTTCTATACCCCAGAGCCAGATACCTGCCATGAACTCTTAGGTCATGTCCCGCTT
TTGGCTGAACCTAGTTTTGCCCAATTCTCCCAAGAAATTGGCTTGGCTTCTCTTGGCGCT
TCAGAGGAGGCTGTTCAAAAACTGGCAACGTGCTACTTTTTCACTGTGGAGTTTGGTCTA
TGTAAACAAGATGGACAGCTAAGAGTCTTTGGTGCTGGCTTACTTTCTTCTATCAGTGAA
CTCAAACATGCACTTTCTGGACATGCCAAAGTAAAGCCCTTTGATCCCAAGATTACCTGC
AAACAGGAATGTCTTATCACAACTTTTCAAGATGTCTACTTTGTATCTGAAAGTTTTGAA
GATGCAAAGGAGAAGATGAGAGAATTTACCAAAACAATTAAGCGTCCATTTGGAGTGAAG
TATAATCCATATACACGGAGTATTCAGATCCTGAAAGACACCAAGAGCATAACCAGTGCC
ATGAATGAGCTGCAGCATGATCTCGATGTTGTCAGTGATGCCCTTGCTAAGGTCAGCAGG
AAGCCGAGTATCTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X52836

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_5_Locus:
11p15.3-p14

# Metabolic_Enzyme_5_SNPs:
rs211107; rs172423; rs2056246; rs211105; rs1800532; rs1799913; rs684302; rs508924; rs1607395; rs685657; rs211102; rs10488683; rs10741734; rs211106; rs169806; rs591556; rs17794760; rs10832874; rs7933505; rs211104; rs11606304; rs11575890; rs2237907; rs11024447; rs685247; rs685249; rs11024449; rs10832876; rs17721739; rs500135; rs480425; rs211108; rs623580; rs10488682; rs2108977; rs8176799; rs12098985; rs7129561; rs41274348; rs41274350; rs503964; rs490895; rs7926900; rs34779435; rs35527095; rs34366393; rs35266509; rs10638620; rs593839; rs10658055; rs593414; rs11575863; rs211100; rs11413954; rs502962; rs211101; rs35668313; rs490966; rs34768875; rs592588; rs3216310; rs34651161; rs12279367; rs12279256; rs491779; rs592576; rs34286483; rs34892919; rs34584326; rs10655479; rs211103; rs12279322; rs592536; rs11024448; rs10832875; rs12287062; rs12279255; rs36020452; rs36063783; rs34067973; rs35878128; rs1134530; rs34396122; rs1133758; rs11024454; rs12365674; rs12575070; rs211109; rs3741201; rs3741202; rs4537731; rs521318; rs6486403; rs652458; rs7110238; rs7122118; rs7130929

# Metabolic_Enzyme_5_General_References:
2377472; 7986090; 9751214; 12379098

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5512

# Metabolic_Enzyme_6_Name:
Phenylalanine-4-hydroxylase

# Metabolic_Enzyme_6_Synonyms:
PAH; Phe-4- monooxygenase

# Metabolic_Enzyme_6_Gene_Name:
PAH

# Metabolic_Enzyme_6_Protein_Sequence:
>Phenylalanine4hydroxylase
MSTAVLENPGLGRKLSDFGQETSYIEDNCNQNGAISLIFSLKEEVGALAKVLRLFEENDV
NLTHIESRPS
RLKKDEYEFFTHLDKRSLPALTNIIKILRHDIGATVHELSRDKKKDTVP
WFPRTIQELDRFANQILSYGA
ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVE
YMEEEKKTWGTVFKTLKSLYKTHACYEYNHIF
PLLEKYCGFHEDNIPQLEDVSQFLQTC
TGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPE
PDICHELLGHVPLFSD
RSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSS
FGELQ
YCLSEKPKLLPLELEKTAIQNYTVTEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYD
PYTQR
IEVLDNTQQLKILADSINSEIGILCSALQKIK

# Metabolic_Enzyme_6_Number_of_Residues:
452

# Metabolic_Enzyme_6_Molecular_Weight:
51863

# Metabolic_Enzyme_6_Theoretical_pI:
6.57

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  phenylalanine 4-monooxygenase activity
Function:  amine binding
Function:  amino acid binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  L-phenylalanine metabolism
Process:  L-phenylalanine catabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_6_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis

# Metabolic_Enzyme_6_Reaction:
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01842:ACT;
PF00351:Biopterin_H

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.16.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
189937

# Metabolic_Enzyme_6_SwissProt_ID:
PH4H_HUMAN (P00439)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
PAH

# Metabolic_Enzyme_6_Geneatlas_id:
PAH

# Metabolic_Enzyme_6_hgnc_id:
HGNC:8582

# Metabolic_Enzyme_6_PDB_ID:
2PHM

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1359 bp

ATGTCCACTGCGGTCCTGGAAAACCCAGGCTTGGGCAGGAAACTCTCTGACTTTGGACA
GGAAACAAGCT
ATATTGAAGACAACTGCAATCAAAATGGTGCCATATCACTGATCTTCT
CACTCAAAGAAGAAGTTGGTGC
ATTGGCCAAAGTATTGCGCTTATTTGAGGAGAATGAT
GTAAACCTGACCCACATTGAATCTAGACCTTCT
CGTTTAAAGAAAGATGAGTATGAATT
TTTCACCCATTTGGATAAACGTAGCCTGCCTGCTCTGACAAACA
TCATCAAGATCTTGA
GGCATGACATTGGTGCCACTGTCCATGAGCTTTCACGAGATAAGAAGAAAGACAC
AGTG
CCCTGGTTCCCAAGAACCATTCAAGAGCTGGACAGATTTGCCAATCAGATTCTCAGCTAT
GGAGCG
GAACTGGATGCTGACCACCCTGGTTTTAAAGATCCTGTGTACCGTGCAAGACG
GAAGCAGTTTGCTGACA
TTGCCTACAACTACCGCCATGGGCAGCCCATCCCTCGAGTGG
AATACATGGAGGAAGAAAAGAAAACATG
GGGCACAGTGTTCAAGACTCTGAAGTCCTTG
TATAAAACCCATGCTTGCTATGAGTACAATCACATTTTT
CCACTTCTTGAAAAGTACTG
TGGCTTCCATGAAGATAACATTCCCCAGCTGGAAGACGTTTCTCAATTCC
TGCAGACTT
GCACTGGTTTCCGCCTCCGACCTGTGGCTGGCCTGCTTTCCTCTCGGGATTTCTTGGGTG
G
CCTGGCCTTCCGAGTCTTCCACTGCACACAGTACATCAGACATGGATCCAAGCCCATG
TATACCCCCGAA
CCTGACATCTGCCATGAGCTGTTGGGACATGTGCCCTTGTTTTCAGA
TCGCAGCTTTGCCCAGTTTTCCC
AGGAAATTGGCCTTGCCTCTCTGGGTGCACCTGATG
AATACATTGAAAAGCTCGCCACAATTTACTGGTT
TACTGTGGAGTTTGGGCTCTGCAAA
CAAGGAGACTCCATAAAGGCATATGGTGCTGGGCTCCTGTCATCC
TTTGGTGAATTACA
GTACTGCTTATCAGAGAAGCCAAAGCTTCTCCCCCTGGAGCTGGAGAAGACAGCCA
TCC
AAAATTACACTGTCACGGAGTTCCAGCCCCTGTATTACGTGGCAGAGAGTTTTAATGATG
CCAAGGA
GAAAGTAAGGAACTTTGCTGCCACAATACCTCGGCCCTTCTCAGTTCGCTAC
GACCCATACACCCAAAGG
ATTGAGGTCTTGGACAATACCCAGCAGCTTAAGATTTTGGC
TGATTCCATTAACAGTGAAATTGGAATCC
TTTGCAGTGCCCTCCAGAAAATAAAGTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
K03020

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_6_Locus:
12q22-q24.2

# Metabolic_Enzyme_6_SNPs:
rs5030849; rs1042503; rs1126758; rs1801152; rs772897; rs2280615; rs1801153; rs2280616; rs1616681; rs1722387; rs940527; rs772893; rs937475; rs1722383; rs1522295; rs2251897; rs1718305; rs1722392; rs1617090; rs2133298; rs2245360; rs12425434; rs2270729; rs11111419; rs10860933; rs1718312; rs10860929; rs2242381; rs1722381; rs1498688; rs1718303; rs1498694; rs2252031; rs2247836; rs2251905; rs10860936; rs2037639; rs2056602; rs4646986; rs12580432; rs1522296; rs10860928; rs1522307; rs10778202; rs2712618; rs10860935; rs10512929; rs10860931; rs4764918; rs1718301; rs772896; rs1353766; rs11836916; rs1718307; rs798709; rs11111412; rs1357765; rs10778201; rs12297049; rs4264203; rs10860930; rs1522304; rs3847931; rs869916; rs7295308; rs1718300; rs772895; rs1391685; rs1718304; rs1718306; rs4646987; rs10778204; rs1915932; rs940528; rs937476; rs1814728; rs1722399; rs7310181; rs1072528; rs1568795; rs2251799; rs870072; rs3805120; rs12306510; rs937474; rs3805122; rs1718297; rs10778209; rs7964033; rs2251894; rs1353767; rs7131709; rs17842947; rs1718302; rs11111413; rs6539058; rs7485666; rs3847930; rs12302563; rs1568792; rs1718310; rs10860934; rs7295112; rs7295979; rs10778205; rs11838076; rs772894; rs1718298; rs7485659; rs1722382; rs10778208; rs1722389; rs12309781; rs7138986; rs12578292; rs2454388; rs11830620; rs3817446; rs11831257; rs11111408; rs7488136; rs7485655; rs11838082; rs7488937; rs12301066; rs34181115; rs34191345; rs3828473; rs772899; rs12309687; rs1718292; rs7958897; rs7958750; rs35774237; rs772898; rs1851381; rs10778203; rs11111411; rs10778207; rs12579415; rs11830089; rs10778200; rs3913258; rs12099586; rs12831013; rs1106703; rs11111414; rs12581989; rs17033372; rs7487151; rs1522306; rs3828474; rs1722390; rs11830010; rs2953059; rs11111410; rs7485683; rs10778206; rs12312872; rs12298125; rs10450750; rs12299182; rs11830600; rs10745953; rs1718311; rs10860932; rs1722401; rs2252026; rs7306260; rs2133296; rs4646988; rs7305565; rs17842946; rs1522305; rs1718299; rs7485331; rs1498691; rs1522299; rs17546516; rs4764917; rs9804733; rs1522297; rs17041406; rs9804734; rs9804735; rs17033310; rs17852373; rs5030860; rs5030850; rs5030844; rs5030859; rs5030853; rs5030845; rs5030841; rs5030858; rs5030846; rs5030857; rs5030842; rs5030847; rs5030856; rs5030843; rs5030848; rs5030854; rs1801145; rs17852374; rs1801146; rs1801147; rs1042575; rs35465699; rs7954004; rs1042517; rs2264807; rs12099867; rs2647897; rs35620841; rs3062641; rs36183603; rs36087290; rs34044682; rs12319699; rs11486309; rs28672962; rs34903440; rs7980371; rs34297779; rs2454390; rs5030855; rs12314561; rs5800541; rs12310461; rs7969007; rs11835429; rs36013270; rs34089141; rs1814727; rs35544736; rs28380089; rs11111416; rs5800545; rs34757647; rs11384108; rs3062683; rs11111403; rs10615224; rs2133295; rs11830601; rs2647898; rs34956913; rs28626587; rs7965426; rs12307398; rs3840258; rs34694965; rs2691046; rs2270730; rs2712619; rs5800539; rs35080156; rs36197099; rs12829528; rs12815628; rs12424675; rs34356627; rs34923793; rs12099657; rs12314229; rs5800540; rs2373950; rs34877550; rs1799970; rs2264808; rs3792590; rs10525182; rs2949366; rs4764717; rs34906755; rs34950520; rs36191797; rs34480214; rs7970760; rs10573967; rs34400076; rs34425560; rs35822536; rs1623295; rs34451887; rs1403053; rs35008014; rs3062642; rs11833762; rs3062651; rs7302089; rs10573968; rs7970836; rs34857170; rs36195189; rs36201576; rs7295778; rs11111415; rs11111404; rs12826510; rs2264805; rs7970576; rs5800538; rs34358876; rs12099871; rs34437790; rs11829260; rs34584245; rs2133297; rs1976893; rs1722391; rs1498692; rs34539983; rs3062690; rs35776069; rs11338333; rs28854495; rs10542654; rs10679406; rs36134134; rs2264624; rs28630510; rs2691045; rs28620071; rs1081847; rs10526127; rs1568791; rs3847932; rs5800537; rs10531439; rs35530192; rs1976895; rs5800543; rs28655776; rs12809761; rs35490165; rs11111409; rs12424546; rs2247184; rs12320836; rs34506832; rs1722384; rs11833709; rs2373951; rs5030852; rs35081455; rs34824304; rs35681476; rs35507682; rs1619404; rs10654199; rs35194286; rs35197515; rs35855475; rs2264625; rs1463823; rs11111405; rs11111418; rs2264806; rs35019215; rs11837660; rs34418090; rs5800535; rs5800536; rs12099868; rs11608454; rs11305173; rs34213541; rs34619720; rs12578276; rs35350743; rs2264623; rs34426190; rs35530065; rs35780730; rs12099870; rs35122890; rs7308175; rs1568793; rs2647899; rs12826142; rs28673013; rs35520828; rs28435260; rs28396626; rs28496869; rs2173444; rs1718309; rs12829846; rs2102005; rs5030861; rs34438405; rs34426240; rs34299540; rs3062645; rs4764919; rs12313998; rs7964941; rs34330841; rs35790027; rs5800542; rs12427231; rs12307663; rs7135561; rs28380242; rs1622379; rs10573966; rs35823784; rs12313245; rs1522298; rs12312033; rs36053636; rs34637625; rs34730283; rs34674687; rs9738302; rs35118563; rs35048664; rs7485315; rs17041408; rs1498690; rs35026116; rs1498689; rs5030654; rs10860925; rs11111402; rs17842962; rs34068029; rs4764916; rs7314670; rs7978669

# Metabolic_Enzyme_6_General_References:
2986678; 2461704; 9406548; 9843368; 9642259; 10694386; 11718561; 1679029; 2246858; 1301187; 8594560; 2840952; 2564729; 2615649; 1975559; 1671810; 2014802; 1672294; 1672290; 1679030; 1709636; 1358789; 1355066; 1363837; 1363838; 8406445; 8098245; 8068076; 8088845; 7833954; 8889583; 8889590; 9048935; 9101291; 9450897; 9521426; 9600453; 9452061; 9452062; 9792407; 9792411; 9852673; 10679941; 11326337; 11180595; 11385716; 11461196

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
6878

# Metabolic_Enzyme_7_Name:
Catalase

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
CAT

# Metabolic_Enzyme_7_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_7_Number_of_Residues:
527

# Metabolic_Enzyme_7_Molecular_Weight:
59757

# Metabolic_Enzyme_7_Theoretical_pI:
7.41

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_7_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_7_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_7_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_7_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
CAT

# Metabolic_Enzyme_7_Geneatlas_id:
CAT

# Metabolic_Enzyme_7_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_7_PDB_ID:
1F4J

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_7_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11p13

# Metabolic_Enzyme_7_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_7_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_7_References:
2900841

# Metabolic_Enzyme_8_ID:
7375

# Metabolic_Enzyme_8_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
Not Available

# Metabolic_Enzyme_8_Gene_Name:
SOD2

# Metabolic_Enzyme_8_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_8_Number_of_Residues:
222

# Metabolic_Enzyme_8_Molecular_Weight:
24722

# Metabolic_Enzyme_8_Theoretical_pI:
8.45

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_8_Pathway:
Not Available

# Metabolic_Enzyme_8_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_8_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_8_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
SOD2

# Metabolic_Enzyme_8_Geneatlas_id:
SOD2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_8_PDB_ID:
1LUV

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q25.3

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_8_References:
16631534; 16891102

# Metabolic_Enzyme_9_ID:
8206

# Metabolic_Enzyme_9_Name:
Nitric-oxide synthase, endothelial

# Metabolic_Enzyme_9_Synonyms:
EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS

# Metabolic_Enzyme_9_Gene_Name:
NOS3

# Metabolic_Enzyme_9_Protein_Sequence:
>Nitricoxide synthase, endothelial
MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLT
QPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAP
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDT
NSP

# Metabolic_Enzyme_9_Number_of_Residues:
1203

# Metabolic_Enzyme_9_Molecular_Weight:
133290

# Metabolic_Enzyme_9_Theoretical_pI:
7.27

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets

# Metabolic_Enzyme_9_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_9_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 1.14.13.39

# Metabolic_Enzyme_9_GenBank_ID_Protein:
189212

# Metabolic_Enzyme_9_SwissProt_ID:
NOS3_HUMAN (P29474)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NOS3

# Metabolic_Enzyme_9_Geneatlas_id:
NOS3

# Metabolic_Enzyme_9_hgnc_id:
HGNC:7876

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cell membrane; caveola. Cytoplasm; cytoskeleton. Golgi apparatus. Note= Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity

# Metabolic_Enzyme_9_Gene_Sequence:
>3612 bp
ATGGGCAACTTGAAGAGCGTGGCCCAGGAGCCTGGGCCACCCTGCGGCCTGGGGCTGGGG
CTGGGCCTTGGGCTGTGCGGCAAGCAGGGCCCAGCCACCCCGGCCCCTGAGCCCAGCCGG
GCCCCAGCATCCCTACTCCCACCAGCGCCAGAACACAGCCCCCCGAGCTCCCCGCTAACC
CAGCCCCCAGAGGGGCCCAAGTTCCCTCGTGTGAAGAACTGGGAGGTGGGGAGCATCACC
TATGACACCCTCAGCGCCCAGGCGCAGCAGGATGGGCCCTGCACCCCAAGACGCTGCCTG
GGCTCCCTGGTATTTCCACGGAAACTACAGGGCCGGCCCTCCCCCGGCCCCCCGGCCCCT
GAGCAGCTGCTGAGTCAGGCCCGGGACTTCATCAACCAGTACTACAGCTCCATTAAGAGG
AGCGGCTCCCAGGCCCACGAACAGCGGCTTCAAGAGGTGGAAGCCGAGGTGGCAGCCACA
GGCACCTACCAGCTTAGGGAGAGCGAGCTGGTGTTCGGGGCTAAGCAGGCCTGGCGCAAC
GCTCCCCGCTGCGTGGGCCGGATCCAGTGGGGGAAGCTGCAGGTGTTCGATGCCCGGGAC
TGCAGGTCTGCACAGGAAATGTTCACCTACATCTGCAACCACATCAAGTATGCCACCAAC
CGGGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCTGCCCTGGCCGAGGAGAC
TTCCGAATCTGGAACAGCCAGCTGGTGCGCTACGCGGGCTACCGGCAGCAGGACGGCTCT
GTGCGGGGGGACCCAGCCAACGTGGAGATCACCGAGCTCTGCATTCAGCACGGCTGGACC
CCAGGAAACGGTCGCTTCGACGTGCTGCCCCTGCTGCTGCAGGCCCCAGATGAGCCCCCA
GAACTCTTCCTTCTGCCCCCCGAGCTGGTCCTTGAGGTGCCCCTGGAGCACCCCACGCTG
GAGTGGTTTGCAGCCCTGGGCCTGCGCTGGTACGCCCTCCCGGCAGTGTCCAACATGCTG
CTGGAAATTGGGGGCCTGGAGTTCCCCGCAGCCCCCTTCAGTGGCTGGTACATGAGCACT
GAGATCGGCACGAGGAACCTGTGTGACCCTCACCGCTACAACATCCTGGAGGATGTGGCT
GTCTGCATGGACCTGGATACCCGGACCACCTCGTCCCTGTGGAAAGACAAGGCAGCAGTG
GAAATCAACGTGGCCGTGCTGCACAGTTACCAGCTAGCCAAAGTCACCATCGTGGACCAC
CACGCCGCCACGGCCTCTTTCATGAAGCACCTGGAGAATGAGCAGAAGGCCAGGGGGGGC
TGCCCTGCAGACTGGGCCTGGATCGTGCCCCCCATCTCGGGCAGCCTCACTCCTGTTTTC
CATCAGGAGATGGTCAACTATTTCCTGTCCCCGGCCTTCCGCTACCAGCCAGACCCCTGG
AAGGGGAGTGCCGCCAAGGGCACCGGCATCACCAGGAAGAAGACCTTTAAAGAAGTGGCC
AACGCCGTGAAGATCTCCGCCTCGCTCATGGGCACGGTGATGGCGAAGCGAGTGAAGGCG
ACAATCCTGTATGGCTCCGAGACCGGCCGGGCCCAGAGCTACGCACAGCAGCTGGGGAGA
CTCTTCCGGAAGGCTTTTGATCCCCGGGTCCTGTGTATGGATGAGTATGACGTGGTGTCC
CTCGAACACGAGACGCTGGTGCTGGTGGTAACCAGCACATTTGGGAATGGGGATCCCCCG
GAGAATGGAGAGAGCTTTGCAGCTGCCCTGATGGAGATGTCCGGCCCCTACAACAGCTCC
CCTCGGCCGGAACAGCACAAGAGTTATAAGATCCGCTTCAACAGCATCTCCTGCTCAGAC
CCACTGGTGTCCTCTTGGCGGCGGAAGAGGAAGGAGTCCAGTAACACAGACAGTGCAGGG
GCCCTGGGCACCCTCAGGTTCTGTGTGTTCGGGCTCGGCTCCCGGGCATACCCCCACTTC
TGCGCCTTTGCTCGTGCCGTGGACACACGGCTGGAGGAACTGGGCGGGGAGCGGCTGCTG
CAGCTGGGCCAGGGCGACGAGCTGTGCGGCCAGGAGGAGGCCTTCCGAGGCTGGGCCCAG
GCTGCCTTCCAGGCCGCCTGTGAGACCTTCTGTGTGGGAGAGGATGCCAAGGCCGCCGCC
CGAGACATCTTCAGCCCCAAACGGAGCTGGAAGCGCCAGAGGTACCGGCTGAGCGCCCAG
GCCGAGGGCCTGCAGTTGCTGCCAGGTCTGATCCACGTGCACAGGCGGAAGATGTTCCAG
GCTACAATCCGCTCAGTGGAAAACCTGCAAAGCAGCAAGTCCACGAGGGCCACCATCCTG
GTGCGCCTGGACACCGGAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCACATAGGT
GTCTGCCCGCCCAACCGGCCCGGCCTTGTGGAGGCGCTGCTGAGCCGCGTGGAGGACCCG
CCGGCGCCCACTGAGCCCGTGGCAGTAGAGCAGCTGGAGAAGGGCAGCCCTGGTGGCCCT
CCCCCCGGCTGGGTGCGGGACCCCCGGCTGCCCCCGTGCACGCTGCGCCAGGCTCTCACC
TTCTTCCTGGACATCACCTCCCCACCCAGCCCTCAGCTCTTGCGGCTGCTCAGCACCTTG
GCAGAAGAGCCCAGGGAACAGCAGGAGCTGGAGGCCCTCAGCCAGGATCCCCGACGCTAC
GAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTCCCGTCG
GTGGCGCTGCCTGCCCCACTGCTCCTCACCCAGCTGCCTCTGCTCCAGCCCCGGTACTAC
TCAGTCAGCTCGGCACCCAGCACCCACCCAGGAGAGATCCACCTCACTGTAGCTGTGCTG
GCATACAGGACTCAGGATGGGCTGGGCCCCCTGCACTATGGAGTCTGCTCCACGTGGCTA
AGCCAGCTCAAGCCCGGAGACCCTGTGCCCTGCTTCATCCGGGGGGCTCCCTCCTTCCGG
CTGCCACCCGATCCCAGCTTGCCCTGCATCCTGGTGGGTCCAGGCACTGGCATTGCCCCC
TTCCGGGGATTCTGGCAGGAGCGGCTGCATGACATTGAGAGCAAAGGGCTGCAGCCCACT
CCCATGACTTTGGTGTTCGGCTGCCGATGCTCCCAACTTGACCATCTCTACCGCGACGAG
GTGCAGAACGCCCAGCAGCGCGGGGTGTTTGGCCGAGTCCTCACCGCCTTCTCCCGGGAA
CCTGACAACCCCAAGACCTACGTGCAGGACATCCTGAGGACGGAGCTGGCTGCGGAGGTG
CACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTTACCATGGCA
ACCAACGTCCTGCAGACCGTGCAGCGCATCCTGGCGACGGAGGGCGACATGGAGCTGGAC
GAGGCCGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTACCACGAAGACATTTTC
GGGCTCACGCTGCGCACCCAGGAGGTGACAAGCCGCATACGCACCCAGAGCTTTTCCTTG
CAGGAGCGTCAGTTGCGGGGCGCAGTGCCCTGGGCGTTCGACCCTCCCGGCTCAGACACC
AACAGCCCCTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M93718

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7q36

# Metabolic_Enzyme_9_SNPs:
rs3918234; rs3918232; rs1799983; rs3918201; rs3918166; rs2566514; rs9282804; rs34967063; rs3918233; rs35281220; rs1549758; rs9282803; rs3918163; rs1800779; rs3918226; rs3918159; rs3918160; rs2243311; rs3918162; rs2070744; rs3918225; rs1800783; rs3918155; rs3918158; rs3918157; rs3918156; rs3918161; rs1808593; rs743507; rs1008140; rs3793341; rs3918196; rs3730002; rs3730003; rs3918188; rs2566511; rs891511; rs3918177; rs3730305; rs3730009; rs867225; rs3918182; rs1007311; rs3834873; rs2853792; rs3918192; rs3918227; rs3918175; rs3918171; rs1800782; rs3918187; rs2853795; rs3918205; rs3918176; rs3918202; rs1541861; rs3918178; rs753482; rs3918204; rs3793342; rs3918174; rs3918167; rs3730010; rs1800781; rs3918203; rs1800780; rs3918198; rs3918180; rs3918194; rs3918184; rs891512; rs3729625; rs743506; rs3918181; rs3918190; rs3918228; rs3918172; rs3918230; rs3918169; rs3918191; rs3730001; rs2853796; rs3918186; rs3918170; rs3918165; rs3918183; rs34919745; rs3730006; rs34372288; rs35795287; rs3918193; rs34554797; rs3918179; rs3918164; rs13305982; rs3918197; rs3918229; rs2243310; rs3918231; rs3918189; rs3918173; rs3918168; rs3918195; rs3918199; rs3918185; rs3918200; rs11771443; rs41377046; rs6947833; rs7792133; rs41508746; rs11552661; rs2566519; rs34417010; rs2566516; rs35886277; rs11371169; rs35480369; rs33915751; rs3730306; rs2566513; rs11974098; rs2566508; rs13305984; rs2566512; rs13311166; rs13310774; rs3730007; rs7776461; rs2853798; rs13305985; rs2853791; rs34110189; rs35771718; rs41385244; rs2853800; rs2566515; rs34833695; rs41490944; rs1799984; rs13310854; rs10539416; rs2566509; rs2566506; rs28763995; rs6969597; rs41322052; rs2853797; rs2853794; rs2566510; rs10539415; rs10255980; rs28763996; rs41408449; rs13310763; rs2566507; rs41394247; rs10595051; rs4725985; rs34617549; rs3828997; rs2853793; rs34204527; rs10531586; rs10265237; rs10276930; rs10277237; rs1064353; rs1077872; rs12666088; rs12703107; rs13307588; rs2373929; rs2373961; rs2373962; rs2566518; rs3134740; rs3730011; rs3730012; rs3800787; rs3918207; rs3918211; rs3918212; rs3918215; rs3918218; rs3918220; rs4496877; rs6951150; rs933163

# Metabolic_Enzyme_9_General_References:
1378832; 1379542; 7688726; 7509596; 7519987; 7514568; 7475956; 10074942; 12437348; 9737779

# Metabolic_Enzyme_9_References:
10580434; 10749876; 10924132; 11356602

# Metabolic_Enzyme_10_ID:
8027

# Metabolic_Enzyme_10_Name:
Nitric-oxide synthase, brain

# Metabolic_Enzyme_10_Synonyms:
NOS type I; Neuronal NOS; N-NOS; nNOS; Constitutive NOS; NC-NOS; bNOS

# Metabolic_Enzyme_10_Gene_Name:
NOS1

# Metabolic_Enzyme_10_Protein_Sequence:
>Nitricoxide synthase, brain
MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS

# Metabolic_Enzyme_10_Number_of_Residues:
1434

# Metabolic_Enzyme_10_Molecular_Weight:
160972

# Metabolic_Enzyme_10_Theoretical_pI:
7.44

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  protein binding
Function:  calmodulin binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter

# Metabolic_Enzyme_10_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_10_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase;
PF00595:PDZ

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 1.14.13.39

# Metabolic_Enzyme_10_GenBank_ID_Protein:
642526

# Metabolic_Enzyme_10_SwissProt_ID:
NOS1_HUMAN (P29475)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
NOS1

# Metabolic_Enzyme_10_Geneatlas_id:
NOS1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:7872

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cell membrane; sarcolemma; peripheral membrane protein. Cell projection; dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity)

# Metabolic_Enzyme_10_Gene_Sequence:
>4305 bp
ATGGAGGATCACATGTTCGGTGTTCAGCAAATCCAGCCCAATGTCATTTCTGTTCGTCTC
TTCAAGCGCAAAGTTGGGGGCCTGGGATTTCTGGTGAAGGAGCGGGTCAGTAAGCCGCCC
GTGATCATCTCTGACCTGATTCGTGGGGGCGCCGCAGAGCAGAGTGGCCTCATCCAGGCC
GGAGACATCATTCTTGCGGTCAACGGCCGGCCCTTGGTGGACCTGAGCTATGACAGCGCC
CTGGAGGTACTCAGAGGCATTGCCTCTGAGACCCACGTGGTCCTCATTCTGAGGGGCCCT
GAAGGTTTCACCACGCACCTGGAGACCACCTTTACAGGTGATGGGACCCCCAAGACCATC
CGGGTGACACAGCCCCTGGGTCCCCCCACCAAAGCCGTGGATCTGTCCCACCAGCCACCG
GCCGGCAAAGAACAGCCCCTGGCAGTGGATGGGGCCTCGGGTCCCGGGAATGGGCCTCAG
CATGCCTACGATGATGGGCAGGAGGCTGGCTCACTCCCCCATGCCAACGGCCTGGCCCCC
AGGCCCCCAGGCCAGGACCCCGCGAAGAAAGCAACCAGAGTCAGCCTCCAAGGCAGAGGG
GAGAACAATGAACTGCTCAAGGAGATAGAGCCTGTGCTGAGCCTTCTCACCAGTGGGAGC
AGAGGGGTCAAGGGAGGGGCACCTGCCAAGGCAGAGATGAAAGATATGGGAATCCAGGTG
GACAGAGATTTGGACGGCAAGTCACACAAACCTCTGCCCCTCGGCGTGGAGAACGACCGA
GTCTTCAATGACCTATGGGGGAAGGGCAATGTGCCTGTCGTCCTCAACAACCCATATTCA
GAGAAGGAGCAGCCCCCCACCTCAGGAAAACAGTCCCCCACAAAGAATGGCAGCCCCTCC
AAGTGTCCACGCTTCCTCAAGGTCAAGAACTGGGAGACTGAGGTGGTTCTCACTGACACC
CTCCACCTTAAGAGCACATTGGAAACGGGATGCACTGAGTACATCTGCATGGGCTCCATC
ATGCATCCTTCTCAGCATGCAAGGAGGCCTGAAGACGTCCGCACAAAAGGACAGCTCTTC
CCTCTCGCCAAAGAGTTTATTGATCAATACTATTCATCAATTAAAAGATTTGGCTCCAAA
GCCCACATGGAAAGGCTGGAAGAGGTGAACAAAGAGATCGACACCACTAGCACTTACCAG
CTCAAGGACACAGAGCTCATCTATGGGGCCAAGCACGCCTGGCGGAATGCCTCGCGCTGT
GTGGGCAGGATCCAGTGGTCCAAGCTGCAGGTATTCGATGCCCGTGACTGCACCACGGCC
CACGGGATGTTCAACTACATCTGTAACCATGTCAAGTATGCCACCAACAAAGGGAACCTC
AGGTCTGCCATCACCATATTCCCCCAGAGGACAGACGGCAAGCACGACTTCCGAGTCTGG
AACTCCCAGCTCATCCGCTACGCTGGCTACAAGCAGCCTGACGGCTCCACCCTGGGGGAC
CCAGCCAATGTGCAGTTCACAGAGATATGCATACAGCAGGGCTGGAAACCGCCTAGAGGC
CGCTTCGATGTCCTGCCGCTCCTGCTTCAGGCCAACGGCAATGACCCTGAGCTCTTCCAG
ATTCCTCCAGAGCTGGTGTTGGAAGTTCCCATCAGGCACCCCAAGTTTGAGTGGTTCAAG
GACCTGGGGCTGAAGTGGTACGGCCTCCCCGCCGTGTCCAACATGCTCCTAGAGATTGGC
GGCCTGGAGTTCAGCGCCTGTCCCTTCAGTGGCTGGTACATGGGCACAGAGATTGGTGTC
CGCGACTACTGTGACAACTCCCGCTACAATATCCTGGAGGAAGTGGCCAAGAAGATGAAC
TTAGACATGAGGAAGACGTCCTCCCTGTGGAAGGACCAGGCGCTGGTGGAGATCAATATC
GCGGTTCTCTATAGCTTCCAGAGTGACAAAGTGACCATTGTTGACCATCACTCCGCCACC
GAGTCCTTCATTAAGCACATGGAGAATGAGTACCGCTGCCGGGGGGGCTGCCCTGCCGAC
TGGGTGTGGATCGTGCCCCCCATGTCCGGAAGCATCACCCCTGTGTTCCACCAGGAGATG
CTCAACTACCGGCTCACCCCCTCCTTCGAATACCAGCCTGATCCCTGGAACACGCATGTC
TGGAAAGGCACCAACGGGACCCCCACAAAGCGGCGAGCCATCGGCTTCAAGAAGCTAGCA
GAAGCTGTCAAGTTCTCGGCCAAGCTGATGGGGCAGGCTATGGCCAAGAGGGTGAAAGCG
ACCATCCTCTATGCCACAGAGACAGGCAAATCGCAAGCTTATGCCAAGACCTTGTGTGAG
ATCTTCAAACACGCCTTTGATGCCAAGGTGATGTCCATGGAAGAATATGACATTGTGCAC
CTGGAACATGAAACTCTGGTCCTTGTGGTCACCAGCACCTTTGGCAATGGAGATCCCCCT
GAGAATGGGGAGAAATTCGGCTGTGCTTTGATGGAAATGAGGCACCCCAACTCTGTGCAG
GAAGAAAGGAAGAGCTACAAGGTCCGATTCAACAGCGTCTCCTCCTACTCTGACTCCCAA
AAATCATCAGGCGATGGGCCCGACCTCAGAGACAACTTTGAGAGTGCTGGACCCCTGGCC
AATGTGAGGTTCTCAGTTTTTGGCCTCGGCTCACGAGCATACCCTCACTTTTGCGCCTTC
GGACACGCTGTGGACACCCTCCTGGAAGAACTGGGAGGGGAGAGGATCCTGAAGATGAGG
GAAGGGGATGAGCTCTGTGGGCAGGAAGAGGCTTTCAGGACCTGGGCCAAGAAGGTCTTC
AAGGCAGCCTGTGATGTCTTCTGTGTGGGAGATGATGTCAACATTGAAAAGGCCAACAAT
TCCCTCATCAGCAATGATCGCAGCTGGAAGAGAAACAAGTTCCGCCTCACCTTTGTGGCC
GAAGCTCCAGAACTCACACAAGGTCTATCCAATGTCCACAAAAAGCGAGTCTCAGCTGCC
CGGCTCCTTAGCCGTCAAAACCTCCAGAGCCCTAAATCCAGTCGGTCAACTATCTTCGTG
CGTCTCCACACCAACGGGAGCCAGGAGCTGCAGTACCAGCCTGGGGACCACCTGGGTGTC
TTCCCTGGCAACCACGAGGACCTCGTGAATGCCCTGATCGAGCGGCTGGAGGACGCGCCG
CCTGTCAACCAGATGGTGAAAGTGGAACTGCTGGAGGAGCGGAACACGGCTTTAGGTGTC
ATCAGTAACTGGACAGACGAGCTCCGCCTCCCGCCCTGCACCATCTTCCAGGCCTTCAAG
TACTACCTGGACATCACCACGCCACCAACGCCTCTGCAGCTGCAGCAGTTTGCCTCCCTA
GCTACCAGCGAGAAGGAGAAGCAGCGTCTGCTGGTCCTCAGCAAGGGTTTGCAGGAGTAC
GAGGAATGGAAATGGGGCAAGAACCCCACCATCGTGGAGGTGCTGGAGGAGTTCCCATCT
ATCCAGATGCCGGCCACCCTGCTCCTGACCCAGCTGTCCCTGCTGCAGCCCCGCTACTAT
TCCATCAGCTCCTCCCCAGACATGTACCCTGATGAAGTGCACCTCACTGTGGCCATCGTT
TCCTACCGCACTCGAGATGGAGAAGGACCAATTCACCACGGCGTATGCTCCTCCTGGCTC
AACCGGATACAGGCTGACGAACTGGTCCCCTGTTTCGTGAGAGGAGCACCCAGCTTCCAC
CTGCCCCGGAACCCCCAAGTCCCCTGCATCCTCGTTGGACCAGGCACCGGCATTGCCCCT
TTCCGAAGCTTCTGGCAACAGCGGCAATTTGATATCCAACACAAAGGAATGAACCCCTGC
CCCATGGTCCTGGTCTTCGGGTGCCGGCAATCCAAGATAGATCATATCTACAGGGAAGAG
ACCCTGCAGGCCAAGAACAAGGGGGTCTTCAGAGAGCTGTACACGGCTTACTCCCGGGAG
CCAGACAAACCAAAGAAGTACGTGCAGGACATCCTGCAGGAGCAGCTGGCGGAGTCTGTG
TACCGAGCCCTGAAGGAGCAAGGGGGCCACATATACGTCTGTGGGGACGTCACCATGGCT
GCTGATGTCCTCAAAGCCATCCAGCGCATCATGACCCAGCAGGGGAAGCTCTCGGCAGAG
GACGCCGGCGTATTCATCAGCCGGATGAGGGATGACAACCGATACCATGAGGATATTTTT
GGAGTCACCCTGCGAACGTACGAAGTGACCAACCGCCTTAGATCTGAGTCCATTGCCTTC
ATTGAAGAGAGCAAAAAAGACACCGATGAGGTTTTCAGCTCCTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U17327

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_10_Locus:
12q24.2-q24.31

# Metabolic_Enzyme_10_SNPs:
rs9658403; rs9658445; rs3741475; rs2293054; rs34375182; rs1047735; rs9658446; rs9658276; rs9658501; rs2293044; rs13377860; rs9658362; rs9658278; rs816296; rs1681506; rs1552227; rs570234; rs576881; rs7298863; rs1123425; rs11068415; rs579604; rs1552228; rs3782218; rs693534; rs7958407; rs3782221; rs10507279; rs499776; rs4767533; rs527590; rs1001087; rs4766845; rs482555; rs17509231; rs10160911; rs545343; rs939473; rs1004356; rs545654; rs7132722; rs10161234; rs2682826; rs11068454; rs571895; rs9658261; rs9658265; rs9658566; rs4767534; rs9658562; rs483589; rs3782219; rs17617937; rs9658559; rs9658266; rs12424669; rs7135565; rs9658565; rs9658567; rs551340; rs3782222; rs9658561; rs9658256; rs9658557; rs1966119; rs3741473; rs3741481; rs11609784; rs9658564; rs7134020; rs12425916; rs4767532; rs9658273; rs9658260; rs16947485; rs9658267; rs16947469; rs9658264; rs7305221; rs9658263; rs7301872; rs9658563; rs4482113; rs1004355; rs34406980; rs9658258; rs9658259; rs9658274; rs16947472; rs11833539; rs2101238; rs9658268; rs12826020; rs17430966; rs471075; rs9658262; rs10850814; rs11068452; rs17431015; rs9658269; rs3782220; rs2650163; rs816353; rs549098; rs2077171; rs816361; rs816357; rs532967; rs2293050; rs1520810; rs2293046; rs884847; rs2293051; rs2291908; rs845820; rs1483757; rs816363; rs2682820; rs1093330; rs12578547; rs7970178; rs7309163; rs6490123; rs816360; rs7133438; rs10850810; rs2293047; rs2293045; rs561712; rs1093325; rs7299154; rs7310618; rs7138586; rs10774909; rs539291; rs10850809; rs522910; rs2650162; rs4767524; rs2006789; rs816352; rs1879418; rs2293048; rs9658498; rs2682825; rs7314935; rs2682822; rs4767525; rs4766836; rs9658474; rs547954; rs2293052; rs2650164; rs3825102; rs904658; rs4767529; rs7961096; rs10850803; rs2682821; rs1353939; rs567581; rs7961147; rs7964845; rs530393; rs7977109; rs939474; rs7298903; rs7295972; rs9658361; rs9658420; rs3782195; rs816354; rs526810; rs549040; rs3782214; rs7967328; rs567910; rs7961049; rs9658335; rs3782202; rs11068447; rs2293053; rs3837438; rs7967614; rs9658443; rs9658447; rs9658321; rs9658463; rs9658315; rs1875140; rs4766842; rs9658309; rs864641; rs9658301; rs816358; rs11068451; rs2682819; rs1879419; rs10744891; rs9658384; rs9658535; rs9658490; rs1520812; rs4767527; rs3741477; rs7312437; rs7308402; rs552268; rs11068422; rs9658426; rs9658551; rs9658304; rs2271984; rs471871; rs9658281; rs9658286; rs11068445; rs9658372; rs12579387; rs12321917; rs9658504; rs816347; rs9658317; rs9658471; rs12099598; rs3782203; rs11611788; rs11068450; rs11836446; rs7304788; rs12829185; rs2893707; rs3782211; rs4766843; rs9658481; rs473640; rs7306863; rs10850805; rs12811583; rs9658300; rs9658450; rs3741476; rs9658491; rs11068438; rs1093327; rs11835005; rs9658397; rs2291909; rs528558; rs816346; rs9658377; rs9658330; rs816348; rs9658534; rs9658427; rs816362; rs3782200; rs9658303; rs9658525; rs9658480; rs9658351; rs11612772; rs474523; rs9658282; rs11068446; rs499262; rs2271986; rs9658536; rs9658340; rs9658382; rs9658354; rs16947411; rs10774910; rs9658449; rs9658505; rs2293055; rs17584270; rs9658479; rs1520811; rs7959232; rs3782212; rs9658552; rs1093328; rs7139134; rs6490121; rs1607817; rs816351; rs3782204; rs2271987; rs9658466; rs3782213; rs816293; rs1093329; rs733334; rs3741480; rs509190; rs6490124; rs7297780; rs2139733; rs3782201; rs9658424; rs9658414; rs4767526; rs816359; rs16947443; rs9658478; rs4766841; rs9658353; rs9658314; rs10850808; rs7960451; rs12830203; rs877995; rs9658544; rs3825103; rs865857; rs9658556; rs551846; rs3215291; rs9658327; rs9658452; rs9658507; rs17617737; rs9658527; rs9658312; rs9658418; rs493948; rs11835908; rs9658339; rs7977360; rs9658391; rs9658432; rs9658532; rs9658408; rs9658293; rs12824048; rs9658518; rs9658409; rs12814350; rs7959158; rs12319599; rs9658367; rs10850806; rs1843019; rs9658325; rs499813; rs4766837; rs9658472; rs9658550; rs9658543; rs11068426; rs3782198; rs1843020; rs492596; rs9658497; rs4767523; rs9658280; rs9658496; rs12319601; rs9658360; rs9658503; rs9658417; rs9658380; rs9658508; rs9658370; rs2393208; rs7979667; rs6490122; rs11068429; rs552275; rs9658526; rs3782206; rs7315796; rs9658464; rs9658313; rs11068437; rs816349; rs41462551; rs497373; rs9658352; rs553715; rs524946; rs9658433; rs9658322; rs9658546; rs10774908; rs9658411; rs9658512; rs7305526; rs9658341; rs904657; rs9658329; rs9658337; rs9658422; rs4766838; rs11282297; rs9658308; rs9658517; rs9658381; rs4767528; rs7306231; rs9658371; rs3782207; rs9658469; rs9658385; rs9658485; rs12424169; rs9658398; rs9658406; rs9658475; rs10850812; rs9658438; rs9658369; rs524945; rs9658465; rs10850804; rs744664; rs884846; rs11068431; rs9658459; rs9658378; rs9658494; rs7968487; rs9658283; rs496505; rs11832564; rs11831562; rs9658522; rs9658399; rs7486002; rs12810591; rs12811676; rs9658515; rs9658419; rs12227767; rs9658323; rs9658529; rs9658387; rs816356; rs11068418; rs9658423; rs9658336; rs505381; rs9658549; rs9658307; rs10850802; rs9658454; rs9658326; rs2271985; rs11068428; rs41386547; rs9658555; rs9658350; rs9658444; rs7139256; rs9658333; rs9658401; rs9658324; rs9658390; rs9658506; rs9658492; rs9658483; rs9658448; rs11068443; rs816297; rs9658388; rs9658318; rs3782196; rs9658458; rs3782208; rs9658453; rs1818732; rs16947421; rs9658524; rs816355; rs16947426; rs12227412; rs9658364; rs508304; rs9658495; rs12423054; rs9658521; rs9658434; rs2056352; rs9658373; rs9658320; rs7303718; rs12815584; rs7978471; rs3782205; rs9658537; rs7957789; rs11068444; rs9658487; rs6490120; rs9658429; rs9658542; rs11068416; rs12422515; rs3741479; rs9658374; rs9658297; rs11068427; rs16947447; rs9658473; rs9658306; rs9658528; rs478027; rs12578810; rs9658548; rs9658305; rs9658462; rs9669709; rs11616132; rs9658247; rs9658255; rs9658570; rs9658573; rs9658251; rs9658254; rs9658253; rs11615277; rs9658252; rs9658574; rs9658250; rs7303761; rs9658482; rs41514244; rs41356652; rs41474747; rs9658279; rs4519169; rs9658356; rs41340250; rs9658275; rs9658533; rs41410247; rs9658500; rs2291906; rs9658545; rs9658277; rs41347148; rs41413747; rs9658302; rs41459647; rs7314856; rs12816421; rs36054002; rs11068456; rs9658272; rs3825106; rs35032440; rs12319061; rs35983257; rs11350853; rs35097914; rs41472247; rs3782217; rs34353855; rs5801225; rs9658271; rs4463915; rs34401373; rs3825107; rs9658569; rs34639968; rs11613900; rs12811414; rs11068455; rs3837440; rs5022854; rs41444054; rs35276550; rs9658558; rs1966118; rs900625; rs12828499; rs35484983; rs7976697; rs12315429; rs35546970; rs34677429; rs10532086; rs3841422; rs12812145; rs3937939; rs35667543; rs34618211; rs34266766; rs35856269; rs12813001; rs36021382; rs41511544; rs9658568; rs12827766; rs12322249; rs1384871; rs3814246; rs11068453; rs36211363; rs550720; rs35253422; rs9658560; rs9658257; rs11610556; rs41502449; rs34054618; rs16947488; rs9658270; rs34539949; rs5801226; rs2133681; rs7304189; rs34482297; rs1384870; rs12307475; rs34494717; rs9658431; rs12829099; rs35718760; rs10532868; rs41376150; rs9658389; rs35666260; rs41372344; rs35405377; rs9658359; rs11068440; rs41485049; rs41472952; rs9658319; rs11068436; rs34872534; rs9658477; rs488484; rs12312476; rs28662816; rs11068419; rs9658541; rs36065807; rs7980322; rs11068425; rs9658538; rs1879415; rs9658531; rs34374129; rs9658467; rs2393207; rs12829054; rs41379845; rs10687797; rs2170784; rs41486744; rs35453078; rs9658316; rs11314930; rs2291907; rs41507951; rs41420145; rs9658328; rs9658553; rs9658425; rs34889380; rs9658456; rs34243436; rs35266333; rs41325947; rs35665808; rs41500645; rs33913257; rs9658413; rs3071370; rs1093326; rs9658410; rs33975959; rs34929026; rs7133096; rs12314660; rs12826953; rs10554360; rs11611292; rs514015; rs41432944; rs35267348; rs11347925; rs34837209; rs9658486; rs9658342; rs12821989; rs12304129; rs9658436; rs11435908; rs17430697; rs9658396; rs35296681; rs17508609; rs9658375; rs9658332; rs36001580; rs1915362; rs9658520; rs9658435; rs34869803; rs12366342; rs12307719; rs9658421; rs41390845; rs9658394; rs36083220; rs9658338; rs35293946; rs9658386; rs12826015; rs41383549; rs35267485; rs10655356; rs34973520; rs41458949; rs9658358; rs41396553; rs17430945; rs9658455; rs35031132; rs3070338; rs9658476; rs9658416; rs9658437; rs7307623; rs41366351; rs13328977; rs9658493; rs9658442; rs1681505; rs555648; rs35223509; rs9658468; rs12827134; rs9658366; rs7308875; rs10565062; rs9658451; rs41503148; rs11423140; rs41383344; rs12307476; rs9658345; rs41420451; rs9658407; rs9658334; rs7297846; rs35879104; rs41455345; rs9658376; rs9658539; rs5801224; rs9658513; rs34947893; rs11068424; rs9658523; rs3837439; rs28607014; rs7971809; rs41476045; rs41455546; rs34631148; rs35303550; rs41399550; rs9658346; rs12300042; rs11068448; rs41457644; rs34022865; rs34229487; rs10611949; rs11068433; rs35736046; rs41497546; rs41486647; rs12812274; rs41361947; rs10672770; rs34828673; rs9658392; rs41395745; rs16947370; rs12829334; rs34305939; rs527540; rs12823828; rs9658509; rs9658540; rs9658355; rs35277030; rs9658292; rs41478451; rs36064109; rs34104292; rs12831124; rs9658344; rs35666257; rs9658295; rs41325949; rs12318813; rs35555584; rs41426547; rs11834656; rs41366451; rs41515346; rs10595279; rs4569079; rs9658395; rs9658402; rs41451245; rs35994161; rs41501744; rs41445448; rs41437349; rs2139734; rs9658511; rs11326692; rs2626134; rs10686986; rs10567372; rs3782197; rs35578100; rs41455545; rs3830565; rs34287548; rs7961022; rs11068423; rs41418246; rs9658415; rs9658412; rs9658470; rs9658357; rs10626233; rs9658287; rs10588671; rs11068439; rs9658489; rs12314144; rs35236225; rs9658291; rs9658488; rs34165543; rs41452648; rs9658290; rs9658393; rs9658441; rs34589596; rs34443779; rs11429761; rs12425008; rs4766840; rs34321698; rs9658310; rs12811988; rs9658484; rs2293049; rs41373045; rs9658461; rs9658428; rs12314981; rs34457241; rs9658349; rs41475345; rs41359947; rs12581092; rs34249731; rs9658516; rs12322448; rs9658298; rs35725343; rs11068442; rs11068449; rs1607818; rs9658368; rs528507; rs9658519; rs35301315; rs35146766; rs11068435; rs35656036; rs36232027; rs9658284; rs9658400; rs3837437; rs35556284; rs12821259; rs9658547; rs9658343; rs11413465; rs9658405; rs12425263; rs12229416; rs4500558; rs9658499; rs34918872; rs36020061; rs34665031; rs28722559; rs11373221; rs9658365; rs35536440; rs41362246; rs9658379; rs41418550; rs12811221; rs11398507; rs9658430; rs34474757; rs10536808; rs9658510; rs9658439; rs4641555; rs11068430; rs35152095; rs34896001; rs41350246; rs28491965; rs11411313; rs10602103; rs9658440; rs11391019; rs12826961; rs9658404; rs9658502; rs41448349; rs36033657; rs11608271; rs41531646; rs9658383; rs35976283; rs1879416; rs2170783; rs9658285; rs9658530; rs9658294; rs12829328; rs35704581; rs33951458; rs816350; rs7137324; rs41494753; rs34385734; rs9658288; rs41417246; rs9658348; rs35750643; rs34322576; rs12815242; rs9658514; rs34438096; rs35320403; rs41384051; rs9658311; rs41337253; rs12308759; rs9658457; rs34594895; rs41344546; rs35285730; rs41403945; rs34411345; rs9658576; rs9658571; rs34041352; rs35842215; rs9658248; rs34133408; rs35873722; rs9658246; rs10693750; rs9658572; rs36077311; rs9658249; rs12818970; rs34230698; rs9658575; rs10774906; rs10774907; rs1105026; rs11068411; rs11068457; rs11068458; rs11068459; rs12302304; rs12423857; rs1273887; rs1879417; rs1915361; rs35611019; rs36016891; rs4767520; rs4767535; rs527017; rs957948

# Metabolic_Enzyme_10_General_References:
7528745; 7515942; 7678401; 8879752; 9111048

# Metabolic_Enzyme_10_References:
12709574; 15161750; 15891335; 16216381

# Metabolic_Enzyme_11_ID:
8379

# Metabolic_Enzyme_11_Name:
Pterin-4-alpha-carbinolamine dehydratase

# Metabolic_Enzyme_11_Synonyms:
PHS; 4-alpha- hydroxy-tetrahydropterin dehydratase; Phenylalanine hydroxylase- stimulating protein; Pterin carbinolamine dehydratase; PCD; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; DCoH

# Metabolic_Enzyme_11_Gene_Name:
PCBD1

# Metabolic_Enzyme_11_Protein_Sequence:
>Pterin4alphacarbinolamine dehydratase
MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKL
DHHPEWFNVY
NKVHITLSTHECAGLSERDINLASFIEQVAVSMT

# Metabolic_Enzyme_11_Number_of_Residues:
104

# Metabolic_Enzyme_11_Molecular_Weight:
12000

# Metabolic_Enzyme_11_Theoretical_pI:
6.80

# Metabolic_Enzyme_11_GO_Classification:
Not Available

# Metabolic_Enzyme_11_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Regulates the dimerization of homeodomain protein HNF-1- alpha and enhances its transcriptional activity

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF01329:Pterin_4a

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 4.2.1.96

# Metabolic_Enzyme_11_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_11_SwissProt_ID:
PHS_HUMAN (P61457)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
PCBD1

# Metabolic_Enzyme_11_Geneatlas_id:
PCBD1

# Metabolic_Enzyme_11_hgnc_id:
HGNC:8646

# Metabolic_Enzyme_11_PDB_ID:
1DCP

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear

# Metabolic_Enzyme_11_Gene_Sequence:
Not Available

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M83742

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_11_Locus:
10q22

# Metabolic_Enzyme_11_SNPs:
rs9712; rs827237; rs827241; rs827242; rs12570183; rs12218438; rs7900028; rs2854611; rs1767233; rs844124; rs16928052; rs2854610; rs11554325; rs15279; rs2630336; rs827238; rs827239; rs7916976; rs2854615; rs2788579; rs12249858; rs10999573; rs12769766; rs2854613; rs2854614; rs1683940; rs827240; rs10999574; rs2854616; rs10999572; rs12783479; rs34835357; rs2630331; rs5786013; rs34500372; rs10999571; rs35541340; rs1683922; rs1683926; rs1059266; rs10762410; rs10823633; rs12248382; rs12252993; rs12253257; rs12259664; rs12264592; rs12267758; rs12770815; rs1338643; rs17533359; rs17533443; rs2688758; rs2691148; rs2881; rs4747110; rs6480465; rs6480466; rs7096028; rs7917488; rs7917828; rs827243; rs827244; rs827246; rs827349; rs827350; rs827351; rs877034; rs923177; rs973982

# Metabolic_Enzyme_11_General_References:
1763325; 7763270; 10098606; 8444860; 8352282; 9760199

# Metabolic_Enzyme_11_References:
10403117; 14729142; 14766237; 8178819

# Macromolecular_Interacting_Partner_1_ID:
6070

# Macromolecular_Interacting_Partner_1_Name:
Dihydrofolate reductase

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
DHFR

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
187

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
21453

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.60

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Macromolecular_Interacting_Partner_1_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_1_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00186:DHFR_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.5.1.3

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
182724

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DYR_HUMAN (P00374)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DHFR

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DHFR

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:2861

# Macromolecular_Interacting_Partner_1_PDB_ID:
1MVT

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
J00140

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q11.2-q13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Macromolecular_Interacting_Partner_1_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Macromolecular_Interacting_Partner_1_References:
4004257; 7756597

# Macromolecular_Interacting_Partner_2_ID:
7197

# Macromolecular_Interacting_Partner_2_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_2_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_2_Signals:
1-26

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2p23.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_2_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_2_References:
16293777; 3009141

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
11009561; 11167133; 11230293; 16160605

# Macromolecular_Interacting_Partner_4_ID:
7551

# Macromolecular_Interacting_Partner_4_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_4_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21.3

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_4_References:
10788433; 8245346; 8883940

# Macromolecular_Interacting_Partner_5_ID:
7552

# Macromolecular_Interacting_Partner_5_Name:
Interferon gamma precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
IFN-gamma; Immune interferon

# Macromolecular_Interacting_Partner_5_Gene_Name:
IFNG

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Interferon gamma precursor
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
166

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
19349

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interferon-gamma receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00714:IFN-gamma

# Macromolecular_Interacting_Partner_5_Signals:
1-23

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
32692

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
IFNG_HUMAN (P01579)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
IFNG

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
IFNG

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:5438

# Macromolecular_Interacting_Partner_5_PDB_ID:
1HIG

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCAA
GGTCGAAGAGCATCCCAGTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X13274

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12q14

# Macromolecular_Interacting_Partner_5_SNPs:
rs2069723; rs2069734; rs2069722; rs2234687; rs1042274; rs2069721; rs2069718; rs1861493; rs2069719; rs2069714; rs2069716; rs2069720; rs1861494; rs2069713; rs2069717; rs9282708; rs2234685; rs3087272; rs2069715; rs2069733; rs2430561; rs2193049; rs2069728; rs2069705; rs2069724; rs2069731; rs2193050; rs2069725; rs2069709; rs3181034; rs2069727; rs2069736; rs2069707; rs7956940; rs7956720; rs2069706; rs2069732; rs9282709; rs2069729; rs2069726; rs2069730; rs2069710; rs7957366; rs35040375; rs35314021; rs34079299; rs2069712; rs10611634; rs2234686; rs34399538; rs2069711; rs28910281; rs10599707; rs35008976; rs35994963; rs2069737; rs35751061; rs7956688; rs2069735; rs35815094; rs3814242; rs4394909; rs2069708; rs10878762; rs10878763; rs11177072; rs11177073; rs11177074; rs11831576; rs12306852; rs12366912; rs12369470; rs2098395; rs2111059; rs2870953; rs3181032; rs3181033; rs3181035; rs6421227; rs6581791; rs6581794; rs6581795; rs7138107; rs7139169; rs7298719; rs7302488; rs7350604; rs7968411; rs7969745

# Macromolecular_Interacting_Partner_5_General_References:
6180322; 6173769; 2860101; 6329718; 6176945; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 1525157

# Macromolecular_Interacting_Partner_5_References:
2120210; 2511835; 8314853; 8724983

# Macromolecular_Interacting_Partner_6_ID:
5319

# Macromolecular_Interacting_Partner_6_Name:
Tyrosinase precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

# Macromolecular_Interacting_Partner_6_Gene_Name:
TYR

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Tyrosinase precursor
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
529

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
60394

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.05

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

# Macromolecular_Interacting_Partner_6_Pathway:
map00350  Tyrosine metabolism;
 map00740  Riboflavin metabolism;
 map00940  Stilbene, coumarine and lignin biosynthesis;
 map00950  Alkaloid biosynthesis I

# Macromolecular_Interacting_Partner_6_Reaction:
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00264:Tyrosinase

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
477-497

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 1.14.18.1

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
340037

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TYRO_HUMAN (P14679)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
TYR

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
TYR

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:12442

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Melanosome; melanosomal membrane; single- pass type I membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1590 bp
ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M27160

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_6_Locus:
11q14-q21

# Macromolecular_Interacting_Partner_6_SNPs:
rs33955261; rs1042602; rs1126809; rs1042608; rs4987234; rs3913543; rs3913544; rs1502267; rs3913542; rs1827430; rs1432447; rs12799137; rs2186640; rs12273884; rs6483004; rs11018524; rs12803764; rs621313; rs7358418; rs7117973; rs7929991; rs11018541; rs6483000; rs11820797; rs10765196; rs11824837; rs4753215; rs11018528; rs12420237; rs1393350; rs12804012; rs4399330; rs7108676; rs6483008; rs6483001; rs12419949; rs1939258; rs7940773; rs7945829; rs6483006; rs591260; rs574028; rs7929015; rs12419351; rs12808785; rs6483002; rs4396293; rs501301; rs3900053; rs11018530; rs7115192; rs6483007; rs7123654; rs7940760; rs10765197; rs9919559; rs3793974; rs16913104; rs1847142; rs7943909; rs16913107; rs7107143; rs17793750; rs7111110; rs12418383; rs1939253; rs4121403; rs7947262; rs2000554; rs12420674; rs12416719; rs1847134; rs12419364; rs7115568; rs11018525; rs12418646; rs7941532; rs11820635; rs7105390; rs12419262; rs16912259; rs6483003; rs2866556; rs12808381; rs7123206; rs3793976; rs10765200; rs10830241; rs12791412; rs12786274; rs16913039; rs2000553; rs7112373; rs7927996; rs7941110; rs12417182; rs12420662; rs11823675; rs10830250; rs7941686; rs12420278; rs4121401; rs7117190; rs12421397; rs4418813; rs12807810; rs12789914; rs10765198; rs10741305; rs12808354; rs12421155; rs12417077; rs12418148; rs11824443; rs10765201; rs2002720; rs1942493; rs12098971; rs12806466; rs7101897; rs1939255; rs2298458; rs17174064; rs7924589; rs11018544; rs10501700; rs12421402; rs12417632; rs3793975; rs7117826; rs10830253; rs17191474; rs12419341; rs12420348; rs594647; rs7129973; rs12280928; rs7117213; rs16912972; rs16912981; rs11018522; rs12417166; rs7103781; rs12280693; rs11820834; rs10830245; rs1939262; rs12799347; rs7933595; rs10830248; rs12808219; rs7942587; rs12421746; rs12574987; rs7940368; rs4601783; rs16913084; rs12420864; rs12419071; rs7116589; rs16913095; rs10501698; rs11018549; rs12416958; rs7925659; rs7358330; rs12270717; rs12365043; rs12421030; rs12577992; rs16912983; rs11018555; rs12793071; rs11018545; rs11018535; rs16912966; rs11828655; rs7947052; rs11828731; rs12795158; rs3936992; rs1939263; rs9919546; rs4290229; rs660491; rs10830240; rs7933594; rs16912262; rs7117255; rs11821815; rs575429; rs10830249; rs6482999; rs1074304; rs10830244; rs11018542; rs11018548; rs17793678; rs645592; rs11018553; rs12799516; rs598769; rs10765199; rs4087499; rs16913089; rs10501699; rs16913011; rs1939251; rs4753214; rs7935604; rs11018543; rs12421505; rs10830239; rs12417327; rs11018532; rs7939929; rs6415994; rs2000555; rs12795171; rs7925468; rs2155148; rs7103787; rs16913040; rs11018562; rs1939252; rs12286618; rs7116973; rs12363772; rs10830243; rs12808283; rs7943159; rs16912994; rs7116716; rs7936840; rs9736253; rs4512823; rs3936623; rs7929736; rs11018539; rs535527; rs2155149; rs2155147; rs12803765; rs877072; rs10830247; rs10830246; rs7934212; rs12417026; rs7117974; rs6485980; rs10830238; rs12799768; rs7924913; rs525883; rs12418178; rs12288824; rs12792733; rs12799349; rs4542415; rs12792959; rs1892924; rs4547091; rs1799989; rs5021654; rs7930949; rs7940945; rs28940878; rs13312744; rs13312739; rs34297847; rs34878847; rs13312741; rs28940880; rs11545463; rs13312740; rs11826502; rs11824499; rs11545464; rs28940877; rs28940879; rs36006590; rs28940876; rs28940881; rs13312743; rs1939261; rs1939260; rs35541275; rs1800421; rs13312738; rs34814690; rs11453031; rs36041295; rs1939254; rs7121593; rs34175287; rs7951381; rs11018554; rs35062445; rs34947445; rs34656455; rs11411684; rs28634864; rs11018559; rs11018540; rs34017963; rs34698766; rs2134299; rs12788302; rs35963892; rs12786392; rs11018547; rs36137175; rs1060297; rs34202080; rs12788985; rs12365772; rs12578000; rs35218219; rs12788993; rs11018560; rs4121402; rs35026809; rs35311585; rs4121397; rs5793396; rs17852431; rs36124916; rs7929045; rs4561218; rs34486762; rs34289520; rs35905469; rs34003066; rs4429061; rs34661861; rs4987235; rs12796520; rs34703992; rs28578270; rs34373463; rs11018523; rs34739346; rs12786829; rs905283; rs5793397; rs12277937; rs11018527; rs34899701; rs34429128; rs34758368; rs34773602; rs1074303; rs36055732; rs12803508; rs13312742; rs16913082; rs36007597; rs12804213; rs35654391; rs10526067; rs28620862; rs12791524; rs35555968; rs11018536; rs7396600; rs10551522; rs34876778; rs11018556; rs1783963; rs35928779; rs7946027; rs12786751; rs7924312; rs4079453; rs4087500; rs3907204; rs35930733; rs35724269; rs12804722; rs7934646; rs35477235; rs35801536; rs34425156; rs41320146; rs1939257; rs12789480; rs34675404; rs12805094; rs11018550; rs35501966; rs35514600; rs34903891; rs12803535; rs12294360; rs4512825; rs34634444; rs592486; rs17852430; rs35663695; rs10573250; rs12788260; rs35032790; rs34621048; rs12099254; rs34873297; rs694934; rs34700959; rs4611200; rs7127196; rs35103430; rs35217407; rs35464565; rs5793398; rs10547762; rs16913085; rs34422026; rs7928821; rs35222097; rs34604882; rs609630; rs12796336; rs10671315; rs35457014; rs12271965; rs7946211; rs12805443; rs35434176; rs12789834; rs4121400; rs12146614; rs35105852; rs3907205; rs35774080; rs35744603; rs1939256; rs35428928; rs648871; rs35937494; rs582480; rs12786390; rs625401; rs11018563; rs12797237; rs636613; rs12788232; rs12807511; rs35959534; rs34067617; rs36098386; rs12788214; rs35518533; rs7112858; rs5793399; rs34584385; rs35607520; rs11018557; rs12805030; rs12574349; rs2008320; rs516696; rs35526885; rs12805221; rs35342940; rs11018551; rs1847136; rs11018538; rs11018546; rs34530512; rs34857319; rs35029283; rs11018534; rs1074305; rs35523924; rs12789159; rs35300336; rs11517465; rs603082; rs34295137; rs28826427; rs34469199; rs12787683; rs35430241; rs35115224; rs35597809; rs12295166; rs4614456; rs905281; rs10583155; rs35770150; rs34754918; rs7924785; rs35581621; rs1987513; rs12786588; rs2173998; rs33998063; rs12285584; rs12805029; rs11381844; rs12099178; rs11018558; rs28625671; rs4121398; rs35531191; rs649687; rs7927845; rs34029150; rs35008750; rs7122606; rs475629; rs34865967; rs34625776; rs35549872; rs4121399; rs35764186; rs3834913; rs7483274; rs11018526; rs12786201; rs1939259; rs28625370; rs35804290; rs34388247; rs16912961; rs35195697; rs7105284; rs35638921; rs7119171; rs12364170; rs10691193; rs28521275; rs11374501; rs10830237; rs11824466; rs11827921; rs12795279; rs1954771; rs35402334; rs7949856; rs949537; rs949538

# Macromolecular_Interacting_Partner_6_General_References:
1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 2480811; 2504160; 11214319; 8477259; 10094567; 2342539; 1970634; 1903591; 1642278; 1899321; 1900309; 1943686; 1487241; 7902671; 8128955; 7955413; 8644824; 9158138; 9259202; 10987646; 10571953; 11295837; 11858948

# Macromolecular_Interacting_Partner_6_References:
10643998; 16293777; 16778797; 7826365

# Macromolecular_Interacting_Partner_7_ID:
7386

# Macromolecular_Interacting_Partner_7_Name:
GTP cyclohydrolase 1 feedback regulatory protein

# Macromolecular_Interacting_Partner_7_Synonyms:
GTP cyclohydrolase I feedback regulatory protein; GFRP; p35

# Macromolecular_Interacting_Partner_7_Gene_Name:
GCHFR

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>GTP cyclohydrolase 1 feedback regulatory protein
MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKL
ERRGFRVLSMTGVGQTLVWCLHKE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
84

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
9698

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_7_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. This inhibition is reversed by L-phenylalanine

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF06399:GFRP

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
1698997

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
GFRP_HUMAN (P30047)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
GCHFR

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
GCHFR

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:4194

# Macromolecular_Interacting_Partner_7_PDB_ID:
1IS8

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>255 bp
ATGCCCTACCTGCTCATCAGCACCCAGATCCGCATGGAGGTGGGCCCCACTATGGTGGGC
GATGAACAGTCGGATCCAGAGCTGATGCAGCATCTGGGGGCTTCAAAGAGAAGAGCCTTG
GGAAACAACTTTTATGAATACTACGTCGATGACCCTCCCCGCATAGTCCTGGACAAGCTG
GAACGCAGGGGCTTCCGTGTGCTGAGCATGACGGGGGTGGGCCAGACGCTGGTGTGGTGT
CTGCACAAGGAGTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
U78190

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_7_Locus:
15q15

# Macromolecular_Interacting_Partner_7_SNPs:
rs2016546; rs6492966; rs2412552; rs7182456; rs2301176; rs2412550; rs7164342; rs3759796; rs35183988; rs2898998; rs35049045; rs7182689; rs36099274; rs8042544; rs35856446; rs36031661; rs11413960; rs10600318; rs2412551; rs7163862; rs12901051; rs34211024; rs11558807; rs12442845; rs12904662; rs12911144; rs16970995; rs16970997; rs1866170; rs2004043; rs2289218; rs2289219; rs35673728; rs3784289; rs3784290; rs6492964; rs7165694; rs7166719; rs7169273; rs7172251; rs7174551; rs7174651; rs7175361; rs7175711; rs8023337; rs8025558; rs8031526; rs8035141

# Macromolecular_Interacting_Partner_7_General_References:
1286669

# Macromolecular_Interacting_Partner_7_References:
15167268; 15649650; 8702680; 9685352

# Macromolecular_Interacting_Partner_8_ID:
6226

# Macromolecular_Interacting_Partner_8_Name:
GTP cyclohydrolase I

# Macromolecular_Interacting_Partner_8_Synonyms:
GTP-CH-I

# Macromolecular_Interacting_Partner_8_Gene_Name:
GCH1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>GTP cyclohydrolase 
IMEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPR
SEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLND
AIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRL
QVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPK
TREEFLTLIRS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
250

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
27903

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
8.82

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cyclohydrolase activity
Function:  GTP cyclohydrolase activity
Function:  GTP cyclohydrolase I activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_8_Specific_Function:
Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown

# Macromolecular_Interacting_Partner_8_Pathway:
map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_8_Reaction:
GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF01227:GTP_cyclohydroI

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
EC 3.5.4.16

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
7242659

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
GCH1_HUMAN (P30793)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
GCH1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
GCH1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4193

# Macromolecular_Interacting_Partner_8_PDB_ID:
1IS8

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>753 bp
ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT
GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG
CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC
GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC
TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG
GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT
ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG
TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG
CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA
GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT
GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA
ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT
CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
Z29434

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_8_Locus:
14q22.1-q22.2

# Macromolecular_Interacting_Partner_8_SNPs:
rs841; rs17128017; rs6572984; rs10136966; rs2878168; rs8004018; rs2183081; rs8007201; rs8004445; rs4411417; rs10133662; rs7492600; rs3783638; rs3783642; rs10131232; rs8017210; rs998259; rs9671371; rs10149945; rs8009759; rs12589758; rs7147286; rs8018688; rs7147201; rs10139282; rs7147200; rs17128021; rs7156475; rs10133661; rs11848732; rs7161034; rs12587434; rs10143089; rs4462519; rs10141456; rs17128052; rs10136545; rs11626298; rs7155501; rs10498472; rs3783641; rs17128050; rs752688; rs3783637; rs12147422; rs17128028; rs10133650; rs2183082; rs10873086; rs2183084; rs10129528; rs10133941; rs17128033; rs8019824; rs17253591; rs7141433; rs9671850; rs8018355; rs12432756; rs11158027; rs8010461; rs2878169; rs10131633; rs8020798; rs10150825; rs3783640; rs3783639; rs10498471; rs10220514; rs8009470; rs10149080; rs2149482; rs11626155; rs4363780; rs10134429; rs7141319; rs11620796; rs7155099; rs17253577; rs11850691; rs12879111; rs10220342; rs7140523; rs10140721; rs7155309; rs2149483; rs1952437; rs17128057; rs11158026; rs8010282; rs10147430; rs4402455; rs10782425; rs7141483; rs8011751; rs10134163; rs10138301; rs4363781; rs10132356; rs10146658; rs11627828; rs10137504; rs10145097; rs17832263; rs10144581; rs3825611; rs12885400; rs10138429; rs17253584; rs11627767; rs10220344; rs8019791; rs10137881; rs11626210; rs10139369; rs9989242; rs2183080; rs7493025; rs9671455; rs7142517; rs17739146; rs10137071; rs3759662; rs10144972; rs11851287; rs17671485; rs10144725; rs17128008; rs3759663; rs17128011; rs11847085; rs10136972; rs41298440; rs41298432; rs41298442; rs987; rs10151500; rs1753589; rs34156666; rs28458175; rs41298438; rs34808879; rs9743836; rs10444720; rs8011712; rs34787772; rs4047209; rs8016730; rs35533684; rs35111582; rs34499089; rs13329058; rs1136927; rs11461307; rs34544088; rs35662681; rs7147040; rs11439363; rs35987298; rs10131563; rs34339930; rs10138594; rs28757745; rs12884925; rs35139021; rs35880039; rs3965763; rs34713671; rs41298436; rs11444305; rs7153566; rs35776259; rs35265487; rs28481447; rs35926285; rs10598935; rs2878170; rs34618298; rs41298426; rs10146709; rs28532361; rs10645822; rs11312854; rs10133449; rs10143025; rs34119917; rs12883072; rs7153186; rs11845055; rs2878171; rs28477407; rs36225285; rs34831360; rs35041629; rs35951874; rs3825610; rs34027548; rs34037186; rs10129468; rs35476604; rs35827455; rs34859174; rs35407542; rs34576183; rs36095464; rs8003903; rs9805909; rs35116635; rs12323905; rs3945570; rs9672037; rs28542181; rs11412107; rs28643468; rs11844799; rs34191865; rs11624963; rs13329045; rs41298430; rs28413055; rs35587902; rs36150047; rs35600814; rs9972204; rs8010689; rs35892399; rs34163543; rs2183083; rs34635384; rs2004633; rs11410453; rs10545051; rs28417208; rs41298434; rs41298428; rs3759660; rs34824784; rs11468814; rs35711887; rs3759661; rs7342548; rs11468813; rs10695628; rs10145336; rs10483639; rs11621165; rs11847771; rs1187894; rs17127998; rs17128004; rs17671345; rs17738966; rs2057368; rs2057369; rs2145945; rs2878172; rs3759664; rs3759665; rs7148831; rs8007267; rs8008858

# Macromolecular_Interacting_Partner_8_General_References:
1520321; 8695054; 1482676; 8666288; 7730309; 8068008; 9222755; 7874165; 7501255; 8957022; 8852666; 9120469; 9328244; 9667588; 9778264; 10987649; 10582612; 10208576; 10076897; 10825351; 11113234; 12391354

# Macromolecular_Interacting_Partner_8_References:
10079965; 10321973; 10496263; 10619653

# Macromolecular_Interacting_Partner_9_ID:
7682

# Macromolecular_Interacting_Partner_9_Name:
Interleukin-2 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
IL-2; T-cell growth factor; TCGF; Aldesleukin

# Macromolecular_Interacting_Partner_9_Gene_Name:
IL2

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Interleukin2 precursor
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
17628

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-2 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00715:IL2

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
5729676

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
IL2_HUMAN (P60568)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
IL2

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
IL2

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6001

# Macromolecular_Interacting_Partner_9_PDB_ID:
1PW6

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>462 bp
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTGCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
J00264

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_9_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_9_SNPs:
rs3087209; rs2069763; rs2069778; rs2069769; rs2069764; rs2069779; rs1479920; rs2069768; rs2069765; rs1479921; rs2069771; rs2069772; rs2069773; rs2069770; rs2069777; rs2069776; rs2069762; rs2067006; rs2069774; rs1479922; rs11575812; rs10019970; rs11575810; rs1051753; rs34762647; rs35084452; rs2069767; rs34501152; rs11575807; rs41304870; rs33988980; rs34863848; rs34419809; rs2448491; rs2069766; rs11575808; rs2069760; rs2069775; rs11575811; rs36215455; rs2069780; rs36215457; rs36215454; rs11575813; rs2069761; rs35007569; rs36215456; rs35104399; rs10027390; rs11932411; rs13435525; rs1479923; rs1479924; rs2219865; rs3136534; rs4833248

# Macromolecular_Interacting_Partner_9_General_References:
6330695; 6403867; 6312994; 6306584; 6608729; 6324170; 7722480; 8824916; 3264184; 3491296; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123

# Macromolecular_Interacting_Partner_9_References:
1535794; 2120210; 2613745; 3490393

# Macromolecular_Interacting_Partner_10_ID:
7130

# Macromolecular_Interacting_Partner_10_Name:
Calmodulin

# Macromolecular_Interacting_Partner_10_Synonyms:
CaM

# Macromolecular_Interacting_Partner_10_Gene_Name:
CALM1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Calmodulin
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
149

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
16838

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
3.84

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00036:efhand

# Macromolecular_Interacting_Partner_10_Signals:
None

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
179888

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
CALM_HUMAN (P62158)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
CALM1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
CALM1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:1442

# Macromolecular_Interacting_Partner_10_PDB_ID:
1IQ5

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>450 bp
ATGGCTGACCAGCTGACTGAGGAGCAGATTGCAGAGTTCAAGGAGGCCTTCTCCCTCTTT
GACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTG
GGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGG
AACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACA
GACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAATGGCTAC
ATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGGAGAAGCTGACCGATGAG
GAGGTGGATGAGATGATCAGGGAGGCTGACATCGATGGAGATGGCCAGGTCAATTATGAA
GAGTTTGTACAGATGATGACTGCAAAGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
J04046

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_10_Locus:
14q24-q31

# Macromolecular_Interacting_Partner_10_SNPs:
rs1059296; rs3179089; rs3814843; rs5871; rs3814845; rs12886342; rs3814846; rs1058903; rs3213718; rs2300499; rs9646173; rs2300501; rs2300502; rs2268433; rs2300497; rs3729787; rs2300500; rs3213719; rs7156456; rs3729785; rs2300496; rs3729783; rs2300498; rs3759708; rs11621831; rs3814847; rs12885713; rs11541171; rs11541170; rs11287138; rs35418035; rs15414; rs12886083; rs1059285; rs3814844; rs12886186; rs11539544; rs35149335; rs11541173; rs12895206; rs33952244; rs7155325; rs3060982; rs10140889; rs41304357; rs35204775; rs28691160; rs41317298; rs34384220; rs7155363; rs35428964; rs33976329; rs34825576; rs3729786; rs41307098; rs12886752; rs28460357; rs12894793; rs34068835; rs34704743; rs5810498; rs35688922; rs4620900; rs7148581; rs34983137; rs10146938; rs10148565; rs10873403; rs11629265; rs12891145; rs17126708; rs17126717; rs17126719; rs2068086; rs2110114; rs2401887; rs2896135; rs4904687; rs6575131; rs6575134; rs7144225; rs8006462; rs876259

# Macromolecular_Interacting_Partner_10_General_References:
3182832; 2445749; 6385987; 2223880; 7925473; 9681195; 12508121; 7093203; 11807546

# Macromolecular_Interacting_Partner_10_References:
1373797; 15235013; 16300634; 7541350

# Macromolecular_Interacting_Partner_11_ID:
5672

# Macromolecular_Interacting_Partner_11_Name:
6-pyruvoyl tetrahydrobiopterin synthase

# Macromolecular_Interacting_Partner_11_Synonyms:
PTPS; PTP synthase

# Macromolecular_Interacting_Partner_11_Gene_Name:
PTS

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>6pyruvoyl tetrahydrobiopterin synthase
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVH
GEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQK
VLPVGVLYKVKVYETDNNIVVYKGE

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
145

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
16386

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.67

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-oxygen lyase activity
Function:  carbon-oxygen lyase activity, acting on phosphates
Function:  6-pyruvoyltetrahydropterin synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Coenzyme transport and metabolism 

# Macromolecular_Interacting_Partner_11_Specific_Function:
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin

# Macromolecular_Interacting_Partner_11_Pathway:
map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_11_Reaction:
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF01242:PTPS

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 4.2.3.12

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
177789

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PTPS_HUMAN (Q03393)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
PTS

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
PTS

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:9689

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>438 bp
ATGAGCACGGAAGGTGGTGGCCGTCGCTGCCAGGCACAAGTGTCCCGCCGCATCTCCTTC
AGCGCGAGCCACCGATTGTACAGTAAATTTCTAAGTGATGAAGAAAACTTGAAACTGTTT
GGGAAATGCAACAATCCAAATGGCCATGGGCACAATTATAAAGTTGTGGTGACAGTACAT
GGAGAGATTGACCCTGCTACGGGAATGGTTATGAATCTGGCTGATCTCAAAAAATATATG
GAGGAGGCGATTATGCAGCCCCTTGATCATAAGAATCTGGATATGGATGTGCCATACTTT
GCAGATGTGGTGAGCACGACTGAAAATGTAGCTGTTTATATCTGGGACAACCTCCAGAAA
GTTCTTCCTGTAGGAGTTCTTTATAAAGTAAAAGTATACGAAACTGACAATAATATTGTG
GTTTATAAAGGAGAATAG

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M97655

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_11_Locus:
11q22.3-q23.3

# Macromolecular_Interacting_Partner_11_SNPs:
rs3819331; rs2518351; rs2676374; rs2518352; rs2564862; rs2518348; rs2564865; rs2564864; rs2564863; rs17851590; rs11541630; rs1126546; rs3211484; rs35196884; rs1139452; rs3018472; rs2564861; rs5794785; rs35989206; rs2676373; rs2518353; rs2518350; rs34252028; rs2904867; rs12291869; rs2518349; rs12291603; rs4025978; rs2435289; rs2676375; rs34457986; rs2435290; rs7945257; rs10690183; rs11464665; rs2019209; rs4369441; rs34155806; rs7105071; rs1154763; rs12293583; rs1367038; rs1811350; rs2217401; rs2518345; rs2518346; rs2518347; rs2676377; rs2904868; rs35082717; rs3758876; rs7110251; rs7938116; rs7941336; rs919479; rs957090; rs975020

# Macromolecular_Interacting_Partner_11_General_References:
1282802; 8216273; 7698774; 8841415; 10531334; 9222755; 8178819; 7493990; 8707300; 9222757; 9159737; 9450907; 10220141

# Macromolecular_Interacting_Partner_11_References:
10321973; 10987137; 14729142; 7698774

# Macromolecular_Interacting_Partner_12_ID:
8080

# Macromolecular_Interacting_Partner_12_Name:
Beta-nerve growth factor precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Beta-NGF

# Macromolecular_Interacting_Partner_12_Gene_Name:
NGFB

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Betanerve growth factor precursor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
241

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
26959

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
10.54

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00243:NGF

# Macromolecular_Interacting_Partner_12_Signals:
1-18

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
671883

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
NGF_HUMAN (P01138)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
NGFB

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
NGFB

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:7808

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>726 bp
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGTCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
V01511

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_12_Locus:
1p13.1

# Macromolecular_Interacting_Partner_12_SNPs:
rs6330; rs11466110; rs11466111; rs6325; rs1318345; rs2747058; rs719452; rs2179926; rs2254404; rs2856813; rs910330; rs2239622; rs10776800; rs2254527; rs3811015; rs4332358; rs10776798; rs4454548; rs4839028; rs4073129; rs4076194; rs4839435; rs4146585; rs6678788; rs4839436; rs6326; rs12082544; rs6328; rs6698675; rs7540561; rs6537860; rs4240542; rs7544068; rs4529705; rs7542555; rs4075872; rs11102929; rs2747063; rs10745349; rs7535026; rs10776799; rs2268792; rs6673867; rs4565713; rs4626883; rs2268793; rs4076018; rs2300692; rs6331; rs6686615; rs10858075; rs12402406; rs11466098; rs17540656; rs4573519; rs10858072; rs10489530; rs12060354; rs7516191; rs11466100; rs11102924; rs7530686; rs3730194; rs2856811; rs10776797; rs12026714; rs11102925; rs17033706; rs7513144; rs4298728; rs17033692; rs17033685; rs10442682; rs11102919; rs12067817; rs4382725; rs4567277; rs3738701; rs11102917; rs11466085; rs11102926; rs7544163; rs7523654; rs17033688; rs10858074; rs4634908; rs2300694; rs7520839; rs11466069; rs11466104; rs11466091; rs11466073; rs4240543; rs11466103; rs11466089; rs11466083; rs11466102; rs12026809; rs11102920; rs12145726; rs12048019; rs11466076; rs11102916; rs11466070; rs10442681; rs6678898; rs11466068; rs11466075; rs12061479; rs7415422; rs11466099; rs7555016; rs11466093; rs6658541; rs11466077; rs17033622; rs11466079; rs11466095; rs2300693; rs11466094; rs4623700; rs10858071; rs11466106; rs11466109; rs12058002; rs11466097; rs11466074; rs3811016; rs12061661; rs17033680; rs2300695; rs11466108; rs4644491; rs11102922; rs4406631; rs12058927; rs11466072; rs12091513; rs12060360; rs11466071; rs4298730; rs11466081; rs11466086; rs10858073; rs11466080; rs11102921; rs11102927; rs7536097; rs12760036; rs11102918; rs11466087; rs11466096; rs11466084; rs4320778; rs11584438; rs4348722; rs4456091; rs4839434; rs6329; rs7417254; rs11466088; rs10158276; rs4240544; rs11466082; rs3811014; rs10776801; rs11102930; rs11466113; rs11466066; rs11466063; rs11466065; rs11466062; rs34542615; rs28758211; rs11466112; rs34079702; rs35941329; rs11466092; rs12727497; rs35833423; rs11579116; rs35290932; rs11302114; rs2284830; rs12749420; rs3730184; rs28645283; rs2747059; rs11466090; rs35070942; rs11102923; rs12088144; rs35067920; rs11102928; rs11580846; rs35755250; rs11466107; rs34024301; rs12023088; rs28735771; rs28461336; rs11579131; rs34357271; rs34257515; rs11579114; rs35884898; rs12025459; rs12119346; rs35221274; rs35274060; rs12073677; rs12070188; rs11584424; rs35329343; rs34377570; rs11485078; rs3730215; rs35658308; rs3021067; rs4417063; rs12731678; rs2747061; rs35447405; rs12047130; rs11579133; rs13374803; rs35225488; rs9970214; rs719451; rs7528234; rs2747056; rs2856814; rs10157426; rs12731680; rs11466078; rs2747055; rs35917469; rs35011726; rs35337130; rs35044546; rs17033682; rs28505352; rs34063775; rs2856812; rs35439338; rs11466105; rs34845120; rs11586039; rs34042023; rs35071824; rs34402529; rs2747057; rs11466114; rs35603764; rs11466064; rs11466061; rs11466067; rs34611363; rs3841009; rs10776802; rs10858076; rs10858077; rs10858078; rs11102915; rs11102932; rs11466059; rs11583020; rs11805062; rs11807499; rs12074502; rs12075799; rs12085129; rs12139760; rs12723944; rs1474798; rs1535093; rs1555207; rs17033589; rs17033597; rs17033602; rs17033725; rs2068797; rs2982740; rs2982741; rs2982742; rs3014804; rs4073110; rs4131272; rs4131273; rs4310443; rs4418592; rs4504888; rs4839029; rs4839030; rs4839031; rs6327; rs6656381; rs6657711; rs6676284; rs6678944; rs6691765; rs7416420; rs7523086; rs7523831; rs7532754; rs7544256; rs926781

# Macromolecular_Interacting_Partner_12_General_References:
6688123; 6327169; 2374737; 10322959; 2025430; 10391209

# Macromolecular_Interacting_Partner_12_References:
10197775; 11716480; 8724983; 9383205

# Macromolecular_Interacting_Partner_13_ID:
8452

# Macromolecular_Interacting_Partner_13_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_13_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_13_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_13_Signals:
1-35

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_13_Locus:
6p21.3

# Macromolecular_Interacting_Partner_13_SNPs:
Not Available

# Macromolecular_Interacting_Partner_13_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_13_References:
15132301; 16052472; 2124251; 8809061

End of HMDB00027

Beginning of HMDB00030
# Accession_No:
HMDB00030

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:40:10

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Biotin

# Description:
A water-soluble, enzyme co-factor present in minute amounts in every living cell. Biotin is also known as vitamin H or B7 or coenzyme R. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin is important in the catalysis of essential metabolic reactions to synthesize fatty acids, in gluconeogenesis, and to metabolize leucine.

# Synonyms:
(+)-Biotin; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valerate; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid; 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate; 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid; Biodermatin; Bioepiderm; Bios II; Biotin; Coenzyme R; D(+)-Biotin; D-(+)-Biotin; D-Biotin; Factor S; Injacom H; Lutavit H2; Meribin; Rovimix H 2; Vitamin B7; Vitamin H; cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate; cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid; hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoate; hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid; hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoate; hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid; delta-(+)-Biotin; delta-Biotin

# Chemical_IUPAC_Name:
5-(3-oxo-7-thia-2,4-diazabicyclo[3.3.0]oct-6-yl)pentanoic acid

# Chemical_Formula:
C10H16N2O3S

# Chemical_Structure:
tbl_chemical:::HMDB00030_ZOOM.png:::119283140313715170

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00030_THUMB.png:::119283140105387587

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
thioether; carboxylic acid; urea; heterocyclic compound

# Taxonomy_Biofunction:
Essential vitamins; Component of Biotin metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
244.08817

# Molecular_Weight_Avg:
244.31064

# Smiles_String_isomeric:
OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12

# Smiles_String_canonical:
OC(=O)CCCCC1SCC2NC(=O)NC12

# KEGG_Compound_ID:
C00120

# BioCyc_ID:
BIOTIN

# PubChem_CID:
171548

# PubChem_SID:
826666; 834755; 10257672; 11486051; 7886365; 825094; 827176; 834758; 11108080; 8022850; 584877; 11466446; 6435802; 835031; 827863; 832719; 826557; 8143739; 826027; 834756; 11467566; 3139816; 838743; 749077; 834754; 842100; 832717; 8023123; 832726; 834757; 835033; 835030; 835032; 832718; 837148; 7853818; 832727; 819610; 832672; 7847097; 8028514; 11110441; 832725; 832724; 822205; 827480; 3420; 6435803; 827375; 834417; 832721

# OMIM_ID:
245400; 253260; 253270; 606054; 607483

# Metagene_ID:
Not Available

# BiGG_ID:
33931

# Wikipedia_ID:
Biotin

# METLIN_ID:
243

# Ref_ID:
10215065; 9022537; 9416479; 9164991; 1814646; 8750932; 2100006; 9176832; 16704206; 10064317; 9371938; 11481419; 12070309; 9038855; 15863846; 8333586; 9094878; 12603856

# ChEBI_ID:
15956

# CAS_Registry_Number:
58-85-5

# InChI:
InChI=1/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

# Synthesis_Reference:
A simple and enantioselective synthesis of (+)-biotin.     Corey, E. J.; Mehrotra, Mukund M.    Dep. Chem.,  Harvard Univ.,  Cambridge,  MA,  USA.    Tetrahedron Letters  (1988),  29(1),  57-60.

# Melting_Point:
232 oC

# Melting_Point_predicted:
115.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.22 mg/mL [MERCK INDEX (1996)]; 3 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1.22 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.17 [Predicted by ALOGPS]; 0.5 [Predicted by PubChem via XLOGP]; 0.39 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Biotin.pdf:::1132562190595561203

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Biotin.mol:::1132723802281899699

# SDF_File_[Text]:
tbl_chemical:::HMDB00030.sdf:::119283139650431089

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00030.pdb:::119283139937613853

# PDB_ID:
1AVD

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AVD.txt:::1132720899156149950

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Biotin.gif:::1132732100125843078

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00030_peaks.txt:::1156309496593954220

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Biotin_C.gif:::1132737660572611528

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00030_peaks.txt:::1156310688415907109

# Mass_Spectrum:
tbl_chemical:::HMDB00030.jpg:::1132798875312425422

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000227.png:::116907444976571912

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000227.txt:::116907444976516942

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000227.png:::116890832115662321

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000227.txt:::116890832143779875

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria; nucleus

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	0.049 +/- 0.035	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	1814646
Urine	0.023 (0.013-0.032)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9022537
Blood	0.0034 (0.002 - 0.0051)	umol/L	Newborn:0-30_days_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0016 (0.0009 - 0.0028)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0024 (0.0008 - 0.0041)	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	0.0012 +/- 0.00067	umol/L	Adult:>18_yrs_old	Both	Normal	1814646 


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Acariasis; Biotin deficiency; Biotin Deficiency Results in Mental Changes (Depression, Hallucinations), Paresthesia, Anorexia, and Nausea; Biotinidase Deficiency; Squamous Carcinoma

# Pathway_Names:
Fatty acid biosynthesis (path 1);Tetracycline biosynthesis;Pyruvate metabolism;Propanoate metabolism;Valine, leucine and isoleucine degradation;Alanine and aspartate metabolism;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;;;;valine,leucine,and_isoleucine_degradation.jpg;Aspartate_and_Alanine_metabolism.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00061;map00253;map00620;map00640;map00280;map00252;map00280;map00280

# Pathway_Graphs:
;;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Aspartate_and_Alanine_metabolism_Graph.jpg;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;;;;valine,leucine,and_isoleucine_degradation.xml;Aspartate_and_Alanine_metabolism.xml;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5247

# Metabolic_Enzyme_1_Name:
Acetyl-CoA carboxylase 2

# Metabolic_Enzyme_1_Synonyms:
ACC-beta[Includes: Biotin carboxylase

# Metabolic_Enzyme_1_Gene_Name:
ACACB

# Metabolic_Enzyme_1_Protein_Sequence:
>AcetylCoA carboxylase 2
MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQR
NGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGT
GTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV
AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHR
DFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVT
PEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL
PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGK
RISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQV
QSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP
LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNL
PAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDE
GFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA
LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGAL
NVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM
NGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP
SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVAR
LELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIK
LKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP
SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRV
EHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSD
ELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP
ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCV
VEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTR
NFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP
ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQL
ELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEY
LQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGS
RLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSF
GNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPK
DILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIG
SFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFK
YLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSL
AYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQL
GGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSR
APYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVE
TRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNREKLPLMIFANWRGF
SGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYA
DKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLK
AREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVK
QEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIR
ENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST

# Metabolic_Enzyme_1_Number_of_Residues:
2458

# Metabolic_Enzyme_1_Molecular_Weight:
276558

# Metabolic_Enzyme_1_Theoretical_pI:
6.46

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

# Metabolic_Enzyme_1_Pathway:
map00061  Fatty acid biosynthesis (path 1);
 map00253  Tetracycline biosynthesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08326:ACC_central;
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF01039:Carboxyl_trans;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_1_Signals:
1-24

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.4.1.2;EC 6.3.4.14

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2138330

# Metabolic_Enzyme_1_SwissProt_ID:
COA2_HUMAN (O00763)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ACACB

# Metabolic_Enzyme_1_Geneatlas_id:
ACACB

# Metabolic_Enzyme_1_hgnc_id:
HGNC:85

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Intracytoplasmic membrane. Note=May associate with membranes

# Metabolic_Enzyme_1_Gene_Sequence:
>7452 bp
ATGGTCTTGCTTCTTTGTCTATCTTGTCTGATTTTCTCCTGTCTGACCTTTTCCTGGTTA
AAAATCTGGGAGAAAATGACGGACTCCAAGCCGATCACCAAGAGTAAATCAGAAGCAAAC
CTCATCCCGAGCCAGGAGCCCTTTCCAGCCTCTGATAACTCAGGGGAGACACCGCAGAGA
AATGGGGAGGGCCACACTCTGCACAAAGACACCCAGCCAGGCCGAGCCCAGCCTCCCACA
AAGGCCCAAAGATCCGGTCGGCGGAGAAACTCCCTACCACCCTCCCGCCAGAAGCCCCCA
AGAAACCCCCTTTCTTCCAGTGACGCAGCACCCTCCCCAGAGCTTCAAGCCAACGGGACT
GGGACACAAGGTCTGGAGGCCACAGATACCAATGGCCTGTCCTCCTCAGCCAGGCCCCAG
GGCAGCAAGCTGGTCCCCTCCAAAGAAGACAAGAAGCAGGCAAACATCAAGAGGCAGCTG
ATGACCAACTTCATCCTGGGCTCTTTTGATGACTACTCCTCCGACGAGGACTCTGTTGCT
GGCTCATCTCGTGAGTCTACCCGGAAGGGCAGCCGGGCCAGCTTGGGGGCCCTGTCCCTG
GAGGCTTATCTGACCACAGGTGAAGCTGAGACCCGCGTCCCCACTATGAGGCCGAGCATG
TCGGGACTCCACCTGGTGAAGAGGGGACGGGAACACAAGAAGCTGGACCTGCACAGAGAC
TTTACCGTGGCTTCTCCCGCTGAGTTTGTCACACGCTTTGGGGGGGATCGGGTCATCGAG
AAGGTGCTTATTGCCAACAACGGGATTGCCGCTGTGAAGTGCATGCGCTCCATCCGCAGG
TGGGCCTATGAGATGTTCCGCAACGAGCGGGCCATCCGGTTTGTTCGCATGGTGACCCCC
GAGGACCTTAAGGCCAACGCAGAGTACATCAAGATGGCGGATCATTACGGGCCCGCCCCA
GGAGGGCCCAATAACAACAACTATGCCAACGTGGAGCTGATTGTGGACATTGCCAAGAGA
ATCCCGTTGCAGGCGGTGTGGGCTGGCTGGGGCCATGCTTTAGAAAACCCTAAACTTCCG
GAGCTGCTGTGCAAGAATGGAGTTGCTTTCTTAGGCCCTCCCAGGTTGAGGCCAATGGTG
GGTCTAGGAGATAAGATCGCCTCCACCGTTGTCGCCCAGACGCTACAGGTCCCAACCCTG
CCCAGGAGTGGAAGCGCCCTGACAGTGGAGTGGACAGAAGATGATCTGCAGCAGGGAAAA
AGAATCAGTGTCCCAGAAGATGTTTATGACAAGGGTTGCGTGAAAGACGTAGATGAGGGC
TTGGAGGCAGCAGAAAGAATTGGTTTTCCATTGATGATCAAAGCTTCTGAAGGTGGCGGA
GGGAAGGGAATCCGGGAAACTGAGAGTGCGGAGGACTTCCCGATCCTTTTCAGACAAGTA
CAGAGTGAGATCCCAGGCTCGCCCATCTTTCTCATGAAGCTGGCCCAGCACGCCCGTCAC
CTGGAAGTTCAGATCCTCGCTGACCAGTATGGGAATGCTGTGTCTCTGTTTGGTCGCGAC
TGCTCCATCCAGCGGCGGCATCAGAAGATCGTTGAGGAAGCACCGGCCACCATCGCGCCG
CTGGCCATATTCGAGTTCATGGAGCAGTGTGCCATTCGCCTGGCCAAGACCGTGGGCTAT
GTGAGTGCAGGGACAGTGGAATACCTCTATAGTCAGGATGGTAGCTTCCACTTCTTGGAG
CTGAATCCTCGCTTGCAGGTGGAACATCCCTGCACAGAAATGATTGCTGACGTTAATCTG
CCGGCCGCCCAGCTACAGATCGCCATGGGTGCCCCACTGCACCGGCTGAAAGATATCCGG
CTTCTGTATGGAGAGTCACCCTGGGGAGACTCCCCAATTTCTTTTGAAAACTCAGCTCAT
CTCCCCTGCCCCCGAGGCCACGTCATTGCCACCAGAATCACCAGCGAAAACCCAGACGAG
GGTTTTAAGCCGAGCTCCGGGACTGTCCAGGAACTGAATTTCCGGAGCAGCAAGAACGTC
TGGGGTTACTTCACGGTGGCCGCTACTGGAGGCCTGCACGAGTTTGCGATTTCCCAGTTT
GGGCACTGCTTCTCCTGGGGAGAGAACCGGAAAGAGGCCATTTCGAACATGGTGGTGGCT
TTGAAGGAACTGTCCCTCCGAGGCGACTTTAGGACTACCGTGGAATACCTCATTAACCTC
CTGGAGACCGAGAGCTTCCAGAACAACTACATCGACACCGGGTGGTTGGACTACCTCATT
GCTGAGAAAGTGCAAAAGAAACCGAATATCATGCTTGGGGTGGTATGCGGGGCCCTTGAA
CGTGGAGATGCGATGTTCAGAACGTGCATGACAGATTTCTTACACTCCCTGGAAAGGGGC
CAGGTCCTCCCAGCGGATTCACTACTGAACCTCGTAGATGTGGAATTAATTTACGAGGGT
GTAAAGTACATTCTAAAGGTGACCCGGCAGTCTCTGACCATGTTCGTTCTCATCATGAAT
GGCTGCCACATCGAGATTGATGCCCACCGGCTGAATGATGGGGGGCTCCTGCTCTCCTAC
AATGGGAACAGCTACACCACCTACATGAAGGAAGAGGTTGACAGTTACCGTACCATCGGC
AATAAGACGTGTGTTTTTGAGAAGGAGAACGATCCTACAGTCCTGAGATCCCCCTCGGCT
GGGAAGCTGACACAGATCACAGTGGAGGATGGGGGCCACGTTGAGGCTGGGAGACGCTAC
GCTGAGATGGAGGTGATGAAGATGATCATGACCCTGAACGTTCAGGAAAGAGGCCGGGTG
AAGTACATCAAGCGTCCAGGTGCGGTGCTGGAAGCAGGCTGCGTGGTGGCCAGGCTGGAG
CTCGATGACCCTTCTAAAGTCCACCCGGCTGAACCGTTCACAGGAGAACTCCCTGCCCAG
CAGAACACTGCCGACCTCGGAAAGAAACTGCACAGGGTCTTCCACAGCGTCCTGGGAAGC
CTCACCAACGTCATGAGTGGCTTTTGTCTGCCAGAGCCGTTTTTTAGCATAAAGCTGAAG
GAGTGGGTGCAGAAGCTCATGATGACCCTCCGGCACCCGTCACTGCTGCTGGACGTGCAG
GAGATCATGACCAGTCGTGCAGGCCGCATCCCCCCCCCTGTTGAGAAGTCTGTCCGCAAG
GTGATGGCCCAGTATGCCAGCAACATCACCTCGGTGCTGTGCCAGTTCCCCAGCCAGCAG
ATAGCCACCATCCTGGACTGCCATGCAGCCACCCTGCAGCGGAAGGCTGATCGAGAGGTC
TTCTTCATCAACACCCAGAGCATGGTGCAGTTGGTCCAGAGGTACCGAAGTGGAATCCGC
GGTCATATGAAAACAGTGGTGATCGATCTCTTGAGAAGATACTTGCGTGTTGAGACCATT
TTCGGCAAGGCAAGAGATGCTGATGCCAACTCCAGTGGGATGGTGGGGGGCGTGAGGAGC
CTGAGCTTTACCTCTGTGTGGGTGGTTTTGTCTCCCCCAGCCCACTACGACAAGTGTGTG
ATAAACCTCAGGGAACAGTTCAAGCCAGACATGTCCCAGGTGCTGGACTGCATCTTCTCC
CACGCACAGGTGACCAAGAAGAACCAGCTGGTGATCATGTTGATCGATGAGCTGTGTGGC
CCAGACCCTTCCCTGTCGGACGAGCTGATCTCCATCCTCAACGAGCTCACTCAGCTGAGC
AAAAGCGAGCACTGCAAAGTGGCCCTCAGAGCCCGGCAGATCCTGATCGCCTCCCCCTCC
TACGAGCTGCGGCATAACCAGGTGGAGTCCATTTTCCTGTCTGCCATTGACATGTACGGC
CACCAGTTCTGCCCCGAGAACCTCCAGAAATTAATACTTTCGGAAACAACCATCTTCGAC
GTCCTGAATACTTTCTTCTATCACGCAAACAAAGTCGTGTGCATGGCGTCCTTGGAGGTT
TACGTGGGGGGGGCTTACATCGCCTATGTGTTAAACAGCCTGCAGCACCGGCAGCTCCCG
GACGGCACCTGCGTGGTAGAATTCCAGTTCATGCTGCCGTCCTCCCACCCAAACCGGATG
ACCGTGCCCATCAGCATCACCAACCCTGACCTGCTGAGGCACACGACAGAGCTCTTCATG
GACAGCGGCTTCTCCCCACTGTGCCAGCGCATGGGAGCCATGGTAGCCTTCAGGAGATTC
GAGGACTTCACCAGAAATTTTGATGAAGTCATCTCTTGCTTCGCCAACGTGCCGAAAGAC
CCCCCCCTCTTCAGCGAGGCCCGCACCTCCCTATACTCCGAGGATGACTGCAAGAGCCTC
AGAGAAGAGCCCATCCACATTCTGAATGTGTCCATCCAGTGTGCGGACCACCTGGAGGAT
GAGGCACTGGTGCCGATTTTACGTACATTCGTACAGTCCAAGAAAAATATCCTTGTGGAT
TATGGACTCCGACGAATCCCATTCTTGATTGCCCAAGAGAAAGAATTTCCCAAGTTTTTC
ACATTCAGAGCAAGAGATGAGTTTGCAGAAGATCGCATTTACCGTCACTTGGAACCTGCC
CTGGCTTTCCAGCTGGAACTCAACCGGATGCGTAACTTCGATCTGACCGCCGTGCCCTGT
GCCAACCACAAGATGCACCTTTACCTGGGTGCTGCCAAGGTGGAAGGAAGGTATGAAGTG
ACGGACCATAGGTTCTTCATCCGTGCCATCATCAGGCACTCTGACCTGATCACAAAGGAA
GCCTCCTTCGAATACCTGCAGAACGAGGGTGAGCGGCTGCTCCTGGAGGCCATGGACGAG
CTGGAGGTGGCGTTCAATAACACCAACGTGCGCACCGACTGCAACCACATCTTCCTCAAC
TTCGTGCCCACTGTCATCATGGACCCCAACAAGATCGAGGAGTCCGTGCGCTACATGGTT
ATGCGCTACGGCAGCCGGCTGTGGAAACTCCGTGTGCTACAGGCTGAGGTCAAGATCAAC
ATCCGCCAGACCACCACCGGCAGTGCCGTTCCCATCCGCCTGTTCATCACCAATGAGTCG
GGCTACTACCTGGACATCAGCCTCTACAAAGAAGTGACTGACTCCAGATCTGGAAATATC
ATGTTTCACTCCTTCGGCAACAAGCAAGGGCCCCAGCACGGGATGCTGATCAATACTCCC
TACGTCACCAAGGATCTGCTCCAGGCCAAGCGATTCCAGGCCCAGACCCTGGGAACCACC
TACATCTATGACTTCCCGGAAATGTTCAGGCAGGCTCTCTTTAAACTGTGGGGCTCCCCA
GACAAGTATCCCAAAGACATCCTGACATACACTGAATTAGTGTTGGACTCTCAGGGCCAG
CTGGTGGAGATGAACCGACTTCCTGGTGGAAATGAGGTGGGCATGGTGGCCTTCAAAATG
AGGTTTAAGACCCAGGAGTACCCGGAAGGACGGGATGTGATCGTCATCGGCAATGACATC
ACCTTTCGCATTGGATCCTTTGGCCCTGGAGAGGACCTTCTGTACCTGCGGGCATCCGAG
ATGGCCCGGGCAGAGGCGATTCCCAAAATTTACGTGGCAGCCAACAGTGGCGCCCGTATT
GGCATGGCAGAGGAGATCAAACACATGTTCCACGTGGCTTGGGTGGACCCAGAAGACCCC
CACAAAGGATTTAAATACCTGTACCTGACTCCCCAAGACTACACCAGAATCAGCTCCCTG
AACTCCGTCCACTGTAAACACATCGAGGAAGGAGGAGAGTCCAGATACATGATCACGGAT
ATCATCGGGAAGGATGATGGCTTGGGCGTGGAGAATCTGAGGGGCTCAGGCATGATTGCT
GGGGAGTCCTCTCTGGCTTACGAAGAGATCGTCACCATTAGCTTGGTGACCTGCCGAGCC
ATTGGGATTGGGGCCTACTTGGTGAGGCTGGGCCAGCGAGTGATCCAGGTGGAGAATTCC
CACATCATCCTCACAGGAGCAAGTGCTCTCAACAAGGTCCTGGGAAGAGAGGTCTACACA
TCCAACAACCAGCTGGGTGGCGTTCAGATCATGCATTACAATGGTGTCTCCCACATCACC
GTGCCAGATGACTTTGAGGGGGTTTATACCATCCTGGAGTGGCTGTCCTATATGCCAAAG
GATAATCACAGCCCTGTCCCTATCATCACACCCACTGACCCCATTGACAGAGAAATTGAA
TTCCTCCCATCCAGAGCTCCCTACGACCCCCGGTGGATGCTTGCAGGAAGGCCTCACCCA
ACTCTGAAGGGAACGTGGCAGAGCGGATTCTTTGACCACGGCAGTTTCAAGGAAATCATG
GCACCCTGGGCGCAGACCGTGGTGACAGGACGAGCAAGGCTTGGGGGGATTCCCGTGGGA
GTGATTGCTGTGGAGACACGGACTGTGGAGGTGGCAGTCCCTGCAGACCCTGCCAACCTG
GATTCTGAGGCCAAGATAATTCAGCAGGCAGGACAGGTGTGGTTCCCAGACTCAGCCTAC
AAAACCGCCCAGGCCATCAAGGACTTCAACCGGGAGAAGTTGCCCCTGATGATCTTTGCC
AACTGGAGGGGGTTCTCCGGTGGCATGAAAGACATGTATGACCAGGTGCTGAAGTTTGGA
GCCTACATCGTGGACGGCCTTAGACAATACAAACAGCCCATCCTGATCTATATCCGCCCT
ATGCGGGAGCTCCGGGGAGGCTCCTGGGTGGTCATAGATGCCACCATCAACCCGCTGTGC
ATAGAAATGTATGCAGACAAAGAGAGCAGGGGTGGTGTTCTGGAACCAGAGGGGACAGTG
GAGATTAAGTTCCGAAAGGAAGATCTGATAAAGTCCATGAGAAGGATCGATCCAGCTTAC
AAGAAGCTCATGGAACAGCTAGGGGAACCTGATCTCTCCGACAAGGACCGAAAGGACCTG
GAGGGCCGGCTAAAGGCTCGCGAGGACCTGCTGCTCCCCATCTACCACCAGGTGGCGGTG
CAGTTCGCCGACTTCCATGACACACCCGGCCGGATGCTGGAGAAGGGCGTCATATCTGAC
ATCCTGGAGTGGAAGACCGCACGCACCTTCCTGTATTGGCGTCTGCGCCGCCTCCTCCTG
GAGGACCAGGTCAAGCAGGAGATCCTGCAGGCCAGCGGGGAGCTGAGTCACGTGCATATC
CAGTCCATGCTGCGTCGCTGGTTCGTGGAGACGGAGGGGGCTGTCAAGGCCTACTTGTGG
GACAACAACCAGGTGGTTGTGCAGTGGCTGGAACAGCACTGGCAGGCAGGGGATGGCCCG
CGCTCCACCATCCGTGAGAACATCACGTACCTGAAGCACGACTCTGTCCTCAAGACCATC
CGAGGCCTGGTTGAAGAAAACCCCGAGGTGGCCGTGGACTGTGTGATATACCTGAGCCAG
CACATCAGCCCAGCTGAGCGGGCGCAGGTCGTTCACCTGCTGTCTACCATGGACAGCCCG
GCCTCCACCTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U89344

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_1_Locus:
12q24.11

# Metabolic_Enzyme_1_SNPs:
rs2300455; rs2075260; rs16940029; rs2878960; rs11065772; rs7135947; rs3742023; rs2241220; rs4766516; rs11065765; rs2075262; rs2075263; rs12013; rs2080530; rs2066925; rs2284685; rs741402; rs34286; rs1642040; rs2300460; rs34274; rs2239607; rs2284689; rs7315465; rs4766547; rs2075258; rs2268403; rs3742026; rs2268391; rs2268389; rs2287221; rs1016331; rs4300440; rs2268392; rs2300453; rs4766565; rs34268; rs2268405; rs4766587; rs34276; rs3858707; rs4766455; rs2268393; rs6606697; rs2430683; rs2268404; rs34270; rs4766538; rs34266; rs2284695; rs12307255; rs759560; rs12818314; rs2300459; rs7974710; rs12818490; rs1654873; rs2075259; rs7974040; rs34275; rs2268400; rs6606694; rs11066004; rs2160602; rs2268390; rs3742027; rs2337855; rs2284691; rs7299171; rs7978168; rs12820677; rs4766564; rs12831686; rs2300452; rs16939985; rs10774608; rs34269; rs10849968; rs10849921; rs2284690; rs34271; rs11615824; rs7300608; rs7301145; rs34279; rs4766457; rs246090; rs2075261; rs34273; rs34267; rs2268388; rs12304751; rs246094; rs12581133; rs12304717; rs10744772; rs2300457; rs7316270; rs7358629; rs7300508; rs246095; rs11833565; rs7976552; rs11613533; rs4766506; rs2300456; rs4766494; rs7298135; rs246092; rs3753166; rs4766537; rs124549; rs2284684; rs4766444; rs7957249; rs2268387; rs246091; rs10849967; rs6606696; rs34285; rs9971877; rs2268384; rs2284693; rs16940082; rs16940038; rs10849926; rs2268399; rs2284694; rs2284686; rs4766584; rs7973985; rs4766548; rs7976245; rs12426388; rs7963249; rs2337857; rs7959681; rs2268385; rs11610260; rs4766583; rs11613784; rs2239608; rs2284700; rs34278; rs11065695; rs6606691; rs759559; rs11065800; rs7133315; rs7302945; rs12302208; rs7311180; rs4766495; rs7966218; rs2268394; rs7314964; rs2003590; rs7971400; rs11065873; rs7957340; rs12426437; rs4766445; rs10744776; rs246096; rs2067239; rs10774607; rs2284699; rs4766496; rs11065725; rs3742024; rs12426971; rs6606692; rs11065994; rs7962615; rs12817756; rs7969911; rs7966016; rs11065808; rs11065760; rs7959980; rs7138373; rs2300454; rs7313527; rs34280; rs10444495; rs7488423; rs7971878; rs7312701; rs12427317; rs7971854; rs12817739; rs12426445; rs2284687; rs2268396; rs6606698; rs2430684; rs2284697; rs34281; rs1654880; rs1654870; rs10732610; rs12824299; rs11616172; rs12297136; rs2268397; rs12823991; rs7968027; rs12425409; rs1642039; rs7295784; rs6606695; rs4766449; rs10849901; rs34708647; rs16940056; rs246089; rs7299500; rs7978359; rs12426447; rs7971745; rs34284; rs12425418; rs11065707; rs2268398; rs12371563; rs7398948; rs12818998; rs2284698; rs11065789; rs124550; rs16934132; rs7979520; rs246093; rs7973602; rs10774612; rs11065802; rs34283; rs246097; rs11609393; rs246088; rs11610881; rs7968098; rs1654874; rs1642041; rs11831322; rs16940069; rs4766454; rs12427320; rs6606693; rs11615890; rs12298635; rs12302686; rs34272; rs34874322; rs10774628; rs11065821; rs1013746; rs34282; rs2284696; rs7976118; rs2300458; rs11836009; rs12582316; rs17848825; rs3742025; rs12826842; rs17848802; rs17848833; rs17848829; rs17848835; rs17848820; rs7970183; rs17848814; rs17848845; rs11065655; rs17848813; rs11548069; rs3832872; rs34748130; rs35990385; rs34512735; rs2284688; rs28488820; rs35774241; rs28547878; rs11612011; rs17848840; rs35231287; rs7315250; rs11065745; rs35195118; rs34972531; rs1109760; rs11615298; rs12298475; rs17848817; rs9788095; rs11065768; rs34484411; rs35696831; rs165969; rs12316576; rs3036244; rs4766498; rs35008047; rs17848821; rs11065799; rs35186286; rs10437833; rs35926930; rs35867442; rs11065801; rs10571468; rs7974907; rs12307691; rs11065736; rs35552400; rs36177511; rs10437834; rs10538426; rs7964396; rs11065928; rs12299461; rs28720807; rs12296234; rs10710817; rs34724260; rs12823966; rs35920161; rs12831074; rs2268395; rs36109526; rs7969465; rs34403757; rs34117730; rs11066012; rs35405212; rs35954050; rs34476328; rs35307494; rs12316357; rs9788220; rs11065658; rs35795929; rs35681511; rs11503164; rs34770418; rs11065940; rs11395613; rs35720403; rs7488422; rs12579892; rs17848815; rs34837288; rs12825055; rs12824057; rs35109388; rs8181692; rs3858708; rs7973342; rs7486876; rs35377986; rs12821387; rs34104231; rs35850916; rs35572712; rs7310593; rs2337853; rs12299192; rs2337854; rs35687063; rs35811875; rs17848844; rs34557433; rs36026617; rs9788203; rs34277; rs16940066; rs36041654; rs11065662; rs2300461; rs34920588; rs11066017; rs4766465; rs36074981; rs34249818; rs7955252; rs12371594; rs28651750; rs12823154; rs35305860; rs35073931; rs12099597; rs2268386; rs34696463; rs35831566; rs7484350; rs5800844; rs11316464; rs36041556; rs36066302; rs17848828; rs11615286; rs16940064; rs35119176; rs12579592; rs34587709; rs12820080; rs34392052; rs34483985; rs12367997; rs34243322; rs35315851; rs34161814; rs16934151; rs3214393; rs3057528; rs34265; rs34289600; rs34435040; rs11066014; rs7969552; rs28720113; rs12298532; rs17848826; rs10624857; rs11610925; rs35399427; rs11611648; rs34705590; rs12824632; rs34681726; rs7953267; rs11065948; rs34174568; rs34959945; rs36042486; rs34726323; rs4766463; rs34849464; rs4766581; rs12313567; rs7131928; rs10668263; rs3216576; rs35999044; rs35102243; rs35804667; rs17848843; rs11614298; rs34163065; rs4540880; rs12314997; rs10661545; rs35966344; rs34264; rs7358773; rs34479274; rs11065895; rs11065721; rs11446315; rs7301465; rs11065775; rs34863094; rs35824270; rs3831809; rs11065990; rs7310798; rs35578182; rs11611744; rs12314181; rs35482988; rs11065797; rs11066016; rs35432960; rs35844029; rs7952806; rs35325175; rs35536047; rs17848819; rs17848836; rs35518223; rs35212189; rs11310506; rs12820656; rs35573065; rs3759388; rs34267119; rs10625076; rs11065726; rs2300451; rs12579902; rs36059668; rs10710816; rs7969904; rs17848818; rs7135143; rs10849899; rs35810122; rs35843775; rs12302530; rs17848804; rs12302388; rs2284692; rs5800843; rs34400478; rs11065798; rs35751957; rs7976048; rs11065723; rs34736443; rs9668738; rs34112199; rs10696128; rs17848848; rs35375735; rs34154284; rs10616119; rs11503165; rs9668198; rs34673513; rs34280406; rs35920688; rs4766493; rs3759389; rs34617875; rs5800845; rs35532847; rs10492215; rs1104738; rs11065634; rs11066035; rs11066064; rs11831841; rs12316092; rs12316300; rs12317282; rs12320115; rs12321538; rs12580798; rs1642036; rs1642037; rs1642038; rs1654875; rs1654876; rs1654884; rs16939972; rs34290629; rs7305012; rs7309513; rs7969109; rs882355

# Metabolic_Enzyme_1_General_References:
9099716; 8670171

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5755

# Metabolic_Enzyme_2_Name:
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
3-methylcrotonyl-CoA carboxylase 2; MCCase subunit beta; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 3- methylcrotonyl-CoA carboxylase non-biotin-containing subunit

# Metabolic_Enzyme_2_Gene_Name:
MCCC2

# Metabolic_Enzyme_2_Protein_Sequence:
>MethylcrotonoylCoA carboxylase beta chain, mitochondrial precursor
MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERV
EHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGII
TGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPR
QADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIF
LAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKL
DVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFA
RIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAK
DGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAAN
VLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLV
LGLSFSAALNAPIEKTDFGIFRM

# Metabolic_Enzyme_2_Number_of_Residues:
563

# Metabolic_Enzyme_2_Molecular_Weight:
61334

# Metabolic_Enzyme_2_Theoretical_pI:
7.75

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_2_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_2_Reaction:
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01039:Carboxyl_trans

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 6.4.1.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
10934059

# Metabolic_Enzyme_2_SwissProt_ID:
MCCC2_HUMAN (Q9HCC0)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MCCC2

# Metabolic_Enzyme_2_Geneatlas_id:
MCCC2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6937

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_2_Gene_Sequence:
>1692 bp
ATGTGGGCCGTCCTGAGGTTAGCCCTGCGGCCGTGTGCCCGCGCCTCTCCCGCCGGGCCG
CGCGCCTATCACGGGGACTCGGTGGCCTCGCTGGGCACCCAGCCGGACTTGGGCTCTGCC
CTCTACCAGGAGAACTACAAGCAGATGAAAGCACTAGTAAATCAGCTCCATGAACGAGTG
GAGCATATAAAACTAGGAGGTGGTGAGAAAGCCCGAGCACTTCACATATCAAGAGGAAAA
CTATTGCCCAGAGAAAGAATTGACAATCTCATAGACCCAGGGTCTCCATTTCTGGAATTA
TCCCAGTTTGCAGGTTACCAGTTATATGACAATGAGGAGGTGCCAGGAGGTGGCATTATT
ACAGGCATTGGAAGAGTATCAGGAGTAGAATGCATGATTATTGCCAATGATGCCACCGTC
AAAGGAGGTGCCTACTACCCAGTGACTGTGAAAAAACAATTACGGGCCCAAGAAATTGCC
ATGCAAAACAGGCTCCCCTGCATCTACTTAGTTGATTCGGGAGGAGCATACTTACCTCGA
CAAGCAGATGTGTTTCCAGATCGAGACCACTTTGGCCGTACATTCTATAATCAGGCAATT
ATGTCTTCTAAAAATATTGCACAGATCGCAGTGGTCATGGGCTCCTGCACCGCAGGAGGA
GCCTATGTGCCTGCCATGGCTGATGAAAACATCATTGTACGCAAGCAGGGTACCATTTTC
TTGGCAGGACCCCCCTTGGTTAAAGCGGCAACTGGGGAAGAAGTATCTGCTGAGGATCTT
GGAGGTGCTGATCTTCATTGCAGAAAGTCTGGAGTAAGTGACCACTGGGCTTTGGATGAT
CATCATGCCCTTCACTTAACTAGGAAGGTTGTGAGGAATCTAAATTATCAGAAGAAATTG
GATGTCACCATTGAACCTTCTGAAGAGCCTTTATTTCCTGCTGATGAATTGTATGGAATA
GTTGGTGCTAACCTTAAGAGGAGCTTTGATGTCCGAGAGGTCATTGCTAGAATCGTGGAT
GGAAGCAGATTCACTGAGTTCAAAGCCTTTTATGGAGACACATTAGTTACAGGATTTGCT
CGAATATTTGGGTACCCAGTAGGTATCGTTGGAAACAACGGAGTTCTCTTTTCTGAATCT
GCAAAAAAGGGTACTCACTTTGTCCAGTTATGCTGCCAAAGAAATATTCCTCTGCTGTTC
CTTCAAAACATTACTGGATTTATGGTTGGTAGAGAGTATGAAGCTGAAGGAATTGCCAAG
GATGGTGCCAAGATGGTGGCCGCTGTGGCCTGTGCCCAAGTGCCTAAGATAACCCTCATC
ATTGGGGGCTCCTATGGAGCCGGAAACTATGGGATGTGTGGCAGAGCGTATAGCCCAAGA
TTTCTCTACATTTGGCCAAATGCTCGTATCTCAGTGATGGGAGGAGAGCAGGCAGCCAAT
GTGTTGGCCACGATAACAAAGGACCAAAGAGCCCGGGAAGGAAAGCAGTTCTCCAGTGCT
GATGAAGCGGCTTTAAAAGAGCCCATCATTAAGAAGTTTGAAGAGGAAGGAAACCCTTAC
TATTCCAGCGCAAGGGTATGGGATGATGGGATCATTGATCCAGCAGACACCAGACTGGTC
TTGGGTCTCAGTTTTAGTGCAGCCCTCAACGCACCAATAGAGAAGACTGACTTCGGTATC
TTCAGGATGTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB050049

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
11406611; 11181649

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5756

# Metabolic_Enzyme_3_Name:
Biotin--protein ligase

# Metabolic_Enzyme_3_Synonyms:
Biotin apo-protein ligase[Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Holocarboxylase synthetase; HCS; Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase

# Metabolic_Enzyme_3_Gene_Name:
HLCS

# Metabolic_Enzyme_3_Protein_Sequence:
>Biotinprotein ligase
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR

# Metabolic_Enzyme_3_Number_of_Residues:
726

# Metabolic_Enzyme_3_Molecular_Weight:
80761

# Metabolic_Enzyme_3_Theoretical_pI:
5.34

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  biotin-protein ligase activity
Function:  biotin-[acetyl-CoA-carboxylase] ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Posttranslational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

# Metabolic_Enzyme_3_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_3_Reaction:
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF02237:BPL_C;
PF03099:BPL_LipA_LipB

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 6.3.4.9;EC 6.3.4.10;EC

# Metabolic_Enzyme_3_GenBank_ID_Protein:
577625

# Metabolic_Enzyme_3_SwissProt_ID:
BPL1_HUMAN (P50747)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HLCS

# Metabolic_Enzyme_3_Geneatlas_id:
HLCS

# Metabolic_Enzyme_3_hgnc_id:
HGNC:4976

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Mitochondrion

# Metabolic_Enzyme_3_Gene_Sequence:
>2181 bp
ATGGAAGATAGACTCCACATGGATAATGGACTGGTACCCCAAAAGATTGTGTCGGTGCAC
TTGCAGGACTCCACTCTGAAGGAAGTTAAGGATCAGGTCTCAAACAAGCAAGCCCAGATC
CTAGAGCCGAAGCCTGAACCTTCTCTTGAGATTAAGCCTGAGCAGGACGGTATGGAGCAT
GTTGGCAGAGATGACCCAAAGGCTCTTGGTGAAGAACCCAAACAAAGGAGAGGCAGTGCC
TCTGGGAGTGAGCCTGCTGGGGACAGTGACAGGGGAGGGGGCCCCGTTGAGCATTATCAC
CTCCATCTGTCTAGTTGCCACGAGTGTCTGGAACTTGAGAACAGCACCATTGAGTCAGTC
AAGTTTGCGTCTGCCGAGAACATTCCAGACCTTCCCTACGATTATAGCAGCAGTTTGGAG
AGTGTTGCTGATGAGACCTCCCCCGAAAGAGAAGGGAGGAGAGTCAACCTCACGGGAAAG
GCACCCAACATCCTCCTCTATGTGGGCTCCGACTCCCAGGAAGCCCTCGGCCGGTTCCAC
GAGGTCCGGTCTGTGCTGGCCGACTGTGTGGACATTGACAGTTATATTCTCTACCACCTG
CTGGAGGACAGTGCTCTCAGAGACCCGTGGACGGACAACTGTCTGCTGTTGGTCATTGCT
ACCAGGGAGTCCATTCCCGAAGACCTGTACCAGAAGTTCATGGCCTATCTTTCTCAGGGA
GGGAAGGTGTTGGGCCTGTCTTCATCCTTCACCTTTGGTGGCTTTCAGGTGACAAGCAAG
GGTGCACTGCACAAGACAGTCCAGAACTTGGTTTTCTCCAAGGCTGACCAGAGCGAGGTG
AAGCTCAGCGTCTTGAGCAGTGGCTGCAGGTACCAGGAAGGCCCCGTCCGGCTCAGCCCC
GGCAGGCTCCAGGGCCACCTGGAGAATGAGGACAAGGACAGGATGATTGTGCATGTGCCT
TTTGGAACTCGCGGGGGAGAAGCTGTTCTTTGCCAGGTGCACTTAGAACTACCTCCCAGC
TCCAACATAGTGCAAACTCCAGAAGATTTTAACTTGCTCAAGTCAAGCAATTTTAGAAGA
TACGAAGTCCTTAGAGAGATTCTGACAACCCTTGGCCTCAGCTGTGACATGAAACAAGTT
CCTGCCTTAACTCCTCTTTACTTGCTGTCAGCTGCGGAGGAAATCAGGGATCCTCTTATG
CAGTGGCTTGGGAAACATGTGGACTCCGAGGGAGAAATAAAATCCGGCCAGCTCTCTCTT
AGATTTGTTTCATCCTACGTGTCTGAAGTAGAAATAACCCCATCTTGTATACCTGTGGTG
ACCAACATGGAGGCCTTCTCATCAGAACATTTCAACTTAGAGATCTATCGCCAAAATCTG
CAGACCAAGCAGTTGGGGAAAGTAATTTTGTTTGCCGAAGTGACCCCCACAACGATGCGT
CTCCTGGATGGGCTGATGTTTCAGACACCGCAGGAAATGGGCTTAATAGTGATCGCGGCC
CGGCAGACCGAGGGCAAAGGACGGGGAGGGAATGTGTGGCTGAGCCCTGTGGGATGTGCT
CTTTCTACTCTGCTCATCTCCATTCCACTGAGATCCCAGCTGGGACAGAGGATCCCGTTT
GTCCAGCATCTGATGTCCGTGGCTGTCGTGGAAGCAGTGAGGTCCATTCCCGAGTATCAG
GATATCAACTTACGAGTGAAGTGGCCCAACGATATTTATTACAGTGACCTCATGAAGATC
GGCGGAGTTCTGGTTAACTCAACACTCATGGGAGAAACATTTTATATACTTATTGGCTGT
GGATTTAATGTGACTAACAGTAACCCTACCATCTGCATCAACGACCTCATCACAGAATAC
AATAAACAACACAAGGCAGAACTGAAGCCCTTAAGAGCCGATTATCTCATCGCCAGAGTC
GTGACTGTGCTGGAGAAACTGATCAAAGAGTTTCAGGACAAAGGGCCCAACAGCGTCCTT
CCCCTTTATTACCGATACTGGGTCCACAGTGGTCAGCAAGTCCATCTGGGCAGCGCAGAG
GGACCAAAGGTGTCCATCGTTGGCCTGGACGATTCTGGCTTCCTCCAGGTTCACCAGGAG
GGCGGCGAGGTTGTGACTGTGCACCCGGACGGCAACTCCTTCGACATGCTGAGAAACCTC
ATCCTCCCCAAACGGCGGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D23672

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
rs1065759; rs1065758; rs2230182; rs2835547; rs2835543; rs2835554; rs2835544; rs1892916; rs2835553; rs2835545; rs2016215; rs2835557; rs2835546; rs2835552; rs9636908; rs2835548; rs2835555; rs1893653; rs2835550; rs2843637; rs3827189; rs2835549; rs2835541; rs4817839; rs12626528; rs8126588; rs8127595; rs2835551; rs11910240; rs12627541; rs6517397; rs369888; rs2835556; rs10084553; rs2845814; rs4816551; rs2409871; rs12483284; rs1571702; rs4817840; rs762373; rs445437; rs997627; rs2032087; rs12483456; rs762376; rs1893654; rs7277523; rs1893655; rs1571700; rs9978381; rs727961; rs6517396; rs3827190; rs3179477; rs6517395; rs4816557; rs7281321; rs14407; rs7276605; rs7283846; rs2409870; rs7277447; rs3819154; rs7282108; rs7280331; rs13052315; rs8127236; rs2835542; rs762374; rs12626531; rs1050706; rs7281251; rs2154530; rs13048613; rs13049125; rs11700650; rs9636909; rs8129634; rs11909178; rs11702480; rs9981774; rs9983516; rs1007423; rs11701986; rs8131277; rs7509886; rs7276406; rs4817832; rs2154533; rs762375; rs12482985; rs4817835; rs11909152; rs2154532; rs8126740; rs4816553; rs2843627; rs7276518; rs1012962; rs7280892; rs1986063; rs9981407; rs16997934; rs7509870; rs1055700; rs2016219; rs8130063; rs3191054; rs7276371; rs9967991; rs412162; rs2154529; rs7282422; rs1050707; rs4817838; rs12626619; rs1055699; rs2032086; rs1007421; rs10084551; rs4817834; rs12626945; rs2843633; rs9974970; rs9976131; rs2835520; rs2835489; rs2835535; rs2835505; rs2835472; rs2835531; rs2835463; rs2073425; rs2835516; rs765321; rs1984020; rs2835537; rs2835511; rs2835506; rs745147; rs2835532; rs2835480; rs2256034; rs2245447; rs2835515; rs2835483; rs2835455; rs2835454; rs2245524; rs2835474; rs2835510; rs2835487; rs1041437; rs2835538; rs2000550; rs2835539; rs2835534; rs2835486; rs2835465; rs2835485; rs2835519; rs2835513; rs2245349; rs2835525; rs2073424; rs3827185; rs3787749; rs2835508; rs2835467; rs7280984; rs2835491; rs2073420; rs2236435; rs2835499; rs762369; rs1892913; rs2156419; rs8134067; rs999373; rs1010385; rs3787755; rs2835500; rs2835458; rs8129544; rs3787759; rs7280602; rs2835527; rs6517385; rs2000549; rs2835484; rs2835471; rs8127309; rs999372; rs2835461; rs6517394; rs3787741; rs2835478; rs2835488; rs2835498; rs6517390; rs2835468; rs8130819; rs2835481; rs2835495; rs2835477; rs2245353; rs3787756; rs8134742; rs11088366; rs12627703; rs2835497; rs2835482; rs2835517; rs2835529; rs2835493; rs2835533; rs2835464; rs1015017; rs9978519; rs743429; rs2835503; rs2835509; rs8134293; rs2835514; rs2835473; rs8133376; rs8129637; rs762370; rs2835502; rs3787771; rs1467857; rs2835476; rs9981318; rs2835466; rs3787751; rs2835526; rs3787764; rs6517386; rs2835528; rs766212; rs928845; rs2835504; rs8131323; rs8133029; rs9977855; rs2835459; rs2187305; rs2835479; rs2156420; rs7282868; rs2835530; rs12627271; rs2835501; rs6517384; rs11702761; rs1009778; rs2845810; rs3787739; rs2845805; rs8131621; rs3787752; rs9941899; rs7278038; rs9981513; rs4402840; rs2835524; rs2845811; rs1023409; rs12627285; rs11910692; rs8134448; rs2850120; rs2835507; rs2835496; rs6517392; rs8130179; rs2073421; rs6517389; rs11701858; rs3787748; rs11088368; rs16994604; rs12627666; rs9981651; rs2835475; rs2073419; rs2835494; rs2016223; rs12151959; rs2845804; rs2835518; rs2845812; rs6517391; rs9977488; rs7279278; rs2835470; rs8132538; rs7275269; rs2276230; rs9680246; rs10483036; rs2835523; rs2835490; rs10154119; rs6517388; rs13047304; rs1029248; rs8131480; rs11088367; rs7276758; rs2070523; rs3827187; rs8134687; rs12481910; rs2835453; rs743430; rs2409842; rs2073422; rs16994521; rs7276082; rs2835457; rs7276265; rs12627662; rs762367; rs9977769; rs3787757; rs2835536; rs13050480; rs2835469; rs2409865; rs2850104; rs2850106; rs11910768; rs7275322; rs725719; rs2105752; rs11702134; rs2236434; rs8134083; rs2845817; rs1029247; rs2835492; rs2835521; rs13052249; rs6517387; rs2073423; rs4817822; rs9636905; rs9647169; rs8127553; rs13047322; rs3787754; rs732252; rs1041832; rs8130235; rs8132874; rs16994508; rs3827188; rs2835462; rs7276185; rs2898312; rs7278981; rs8133818; rs999374; rs11911767; rs16994519; rs11701035; rs3787750; rs2073418; rs2850118; rs3787765; rs7277563; rs2835460; rs17228878; rs11701632; rs13050751; rs8131510; rs8129230; rs8132327; rs7278075; rs6517381; rs2245325; rs3842450; rs4817828; rs7283004; rs16997932; rs12627476; rs7281419; rs16994573; rs11700783; rs2065303; rs17192962; rs11700880; rs8129291; rs8131843; rs11088365; rs4501027; rs8132225; rs3838087; rs7278053; rs12627335; rs933159; rs762368; rs3787767; rs7280590; rs12481800; rs8130004; rs3787753; rs12483475; rs17814272; rs10451759; rs8129887; rs2282501; rs9647072; rs7510213; rs8132547; rs12482724; rs3787768; rs4817823; rs1968034; rs16994591; rs12626955; rs9977713; rs8126803; rs7279810; rs12626368; rs16994424; rs2845819; rs11702434; rs8129140; rs8132325; rs960498; rs11702727; rs8130658; rs1968035; rs12627519; rs3787740; rs17814278; rs13052574; rs9978312; rs4817821; rs8134086; rs11909707; rs8131697; rs16994586; rs4146071; rs3787760; rs7509790; rs7280746; rs11909766; rs2835522; rs2850119; rs2845813; rs7279818; rs16994438; rs2409867; rs11911648; rs7283401; rs17228899; rs1892912; rs17284196; rs16994530; rs2835456; rs9305605; rs11701958; rs11910919; rs7283417; rs16994503; rs2835512; rs7283871; rs16994435; rs8130485; rs8130689; rs9985116; rs10154239; rs7280597; rs2850105; rs16994594; rs2850103; rs7280357; rs7283538; rs13045992; rs11088364; rs2898305; rs2032320; rs2096494; rs28934602; rs10586592; rs7280923; rs11393391; rs4817837; rs3035109; rs10555694; rs6147500; rs28593435; rs2010867; rs13050516; rs4816555; rs35275580; rs11911628; rs3035147; rs13047776; rs10439668; rs2250250; rs9976746; rs35410170; rs34322027; rs11088370; rs9978378; rs34080483; rs4817833; rs5843777; rs34917953; rs12481939; rs35414914; rs7283304; rs8130102; rs35626237; rs4817836; rs34507014; rs3035114; rs11911653; rs35627163; rs35955622; rs35662085; rs35497414; rs2154531; rs12627081; rs9975027; rs13046475; rs9980304; rs7281145; rs10714466; rs35614243; rs9979522; rs11327894; rs35458660; rs34562090; rs28690635; rs33973072; rs28429232; rs34401947; rs11446217; rs11386640; rs8131045; rs35291269; rs28650072; rs1571701; rs4816552; rs34710014; rs12627106; rs2848944; rs28694191; rs28530; rs11326506; rs3031056; rs34107101; rs10572120; rs35365431; rs10658878; rs28873986; rs35392286; rs35583976; rs2845823; rs35174119; rs34036236; rs35269254; rs11345329; rs7276359; rs7280124; rs2848945; rs7276076; rs13050356; rs5843783; rs13049535; rs35601107; rs34807872; rs2845822; rs1540010; rs2843959; rs34377311; rs12626655; rs35868871; rs35980239; rs35710980; rs4816554; rs35634082; rs13049080; rs34220466; rs35662012; rs35520036; rs34080155; rs13046468; rs13050438; rs3035105; rs7280358; rs13050355; rs35779811; rs36112603; rs28610288; rs13050617; rs8128381; rs12481773; rs3787776; rs35700333; rs3035112; rs33951816; rs13051338; rs9984942; rs13052725; rs34357006; rs8133111; rs36042341; rs9983255; rs35509622; rs2850116; rs35869521; rs11294369; rs35182597; rs4437044; rs11297044; rs12483583; rs9305606; rs9680205; rs35822038; rs5843781; rs11702621; rs13053024; rs35796252; rs35095559; rs34254252; rs2845809; rs34407031; rs34091454; rs12152092; rs11701245; rs34788426; rs11390960; rs1892914; rs2409866; rs10533053; rs13050215; rs34132309; rs1080320; rs11367391; rs34296856; rs4817819; rs34750859; rs7510407; rs10222039; rs10222041; rs34494258; rs36115487; rs10527838; rs7281668; rs10675191; rs12482385; rs36094571; rs34518438; rs11700970; rs7280703; rs35996984; rs34580139; rs11701954; rs4816549; rs36030626; rs35066001; rs7278768; rs35736294; rs28433522; rs34042688; rs10667373; rs34834985; rs35033735; rs28420273; rs34614171; rs4817826; rs13048483; rs10578979; rs34474993; rs9978513; rs35086153; rs7281557; rs35055957; rs28717023; rs34606135; rs34108918; rs34352427; rs9305607; rs4817820; rs10673271; rs34525201; rs11464249; rs10671954; rs34011883; rs34569598; rs13048364; rs35780817; rs3787762; rs1807005; rs7277291; rs35188541; rs2850117; rs35393537; rs34364909; rs11297456; rs34450454; rs6517380; rs34753772; rs2845818; rs34057978; rs8128030; rs34115036; rs7276860; rs35778622; rs2845808; rs11384058; rs12626778; rs10701851; rs35753864; rs13049458; rs9980828; rs8127419; rs35751606; rs11909879; rs11297170; rs35402890; rs34791770; rs35945376; rs34814328; rs28478303; rs2850107; rs34260234; rs10660857; rs12482621; rs34247489; rs34777766; rs11306825; rs36038593; rs34292112; rs34938617; rs11418922; rs34340177; rs8133296; rs11317768; rs7278191; rs2898307; rs9975316; rs11701120; rs34199456; rs36086662; rs11291576; rs35352430; rs35493457; rs8130859; rs34541224; rs2845815; rs9979967; rs35818278; rs8134476; rs35808041; rs33933191; rs34276663; rs17461392; rs13047682; rs7283722; rs28837399; rs2845807; rs2845816; rs13047748; rs12627632; rs34836716; rs7281692; rs34141324; rs8134223; rs35389223; rs8127533; rs35468614; rs8128099; rs35329905; rs11908840; rs12627303; rs10460714; rs7278010; rs34602439; rs34203769; rs2409864; rs1023151; rs28393024; rs34954888; rs34016490; rs35012674; rs8134332; rs35663376; rs35419478; rs13047923; rs35436718; rs4146072; rs34087473; rs36053269; rs34963503; rs9305608; rs9636906; rs34820991; rs35737292; rs35524379; rs7277631; rs3787747; rs34722227; rs11464248; rs34473124; rs34498809; rs5843779; rs4817824; rs11344082; rs10683958; rs766213; rs36004832; rs35877361; rs36071670; rs10601692; rs8127710; rs35854823; rs34695780; rs2898306; rs34861975; rs11445706; rs3787763; rs35372493; rs35181716; rs4817829; rs35148498; rs13052306; rs34623773; rs9982979; rs34491680; rs8128357; rs765322; rs12627215; rs35114323; rs34254349; rs7279029; rs5843780; rs4817825; rs6517382; rs8134282; rs3838088; rs35086549; rs35178355; rs36094620; rs2845806; rs34601566; rs16994535; rs34372660; rs2409841; rs7276595; rs34045793; rs35693831; rs9636907; rs33997626; rs35529573; rs13049750; rs9631176; rs35395049; rs35754533; rs34877069; rs35184977; rs28625302; rs11701876; rs34016299; rs3840081; rs2409868; rs11287408; rs35744528; rs11908847; rs35420087; rs11290275; rs11323079; rs35056286; rs10699749; rs35246209; rs11464250; rs7280002; rs5843778; rs35247519; rs11353178; rs36000333; rs11088363; rs34153712; rs34389255; rs16994517; rs35042573; rs36027016; rs35323345; rs11701088; rs11464247; rs34592171; rs35050680; rs34390839; rs10696901; rs8127560; rs34392668; rs9680178; rs34427088; rs9984754; rs36040380; rs34908465; rs7282396; rs34792541; rs3132398; rs2843630; rs3094305; rs2843629; rs35788112; rs1005404; rs12627480; rs13050453; rs13052602; rs16994660; rs1892915; rs1893656; rs1970053; rs2002799; rs2051397; rs2070519; rs2070520; rs2073416; rs2073417; rs2073601; rs2073602; rs2073603; rs2186335; rs2187102; rs2409872; rs2835451; rs2835540; rs2843961; rs7281817; rs8131293; rs8132470; rs877686; rs9982519

# Metabolic_Enzyme_3_General_References:
7842009; 11735028; 10830953; 9503011; 8541348; 8817339; 9396568; 10190325

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5757

# Metabolic_Enzyme_4_Name:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
3-methylcrotonyl-CoA carboxylase 1; MCCase subunit alpha; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; 3- methylcrotonyl-CoA carboxylase biotin-containing subunit

# Metabolic_Enzyme_4_Gene_Name:
MCCC1

# Metabolic_Enzyme_4_Protein_Sequence:
>MethylcrotonoylCoA carboxylase subunit alpha, mitochondrial precursor
MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEI
ACRVMRTAKK
LGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKT
SAAQAIHPGCGFLSENMEFAE
LCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVV
EGYHGEDQSDQCLKEHARRIGYPVMIKAVRGG
GGKGMRIVRSEQEFQEQLESARREAKK
SFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR
RHQKIIEEAPAPGIKS
EVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMI
TGTDL
VEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTR
IETGV
RQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLS
GHPEFEAGNVHTDFIP
QHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQ
FSPFSSSSGRRLNISYTRNMTLKDGKN
NVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSE
GDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEID
IPVPKYLSSVSSQETQGGPLA
PMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYR
EGAQANRHTP
LVEFEEEESDKRESE

# Metabolic_Enzyme_4_Number_of_Residues:
725

# Metabolic_Enzyme_4_Molecular_Weight:
80474

# Metabolic_Enzyme_4_Theoretical_pI:
7.86

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_4_Pathway:
map00280  Valine, leucine and isoleucine degradation

# Metabolic_Enzyme_4_Reaction:
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_4_Signals:
1-14

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 6.4.1.4

# Metabolic_Enzyme_4_GenBank_ID_Protein:
12382296

# Metabolic_Enzyme_4_SwissProt_ID:
MCCA_HUMAN (Q96RQ3)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
MCCC1

# Metabolic_Enzyme_4_Geneatlas_id:
MCCC1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:6936

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>2178 bp

ATGGCGGCGGCCTCTGCGGTGTCGGTGCTGCTGGTGGCGGCGGAGAGGAACCGGTGGCA
TCGTCTCCCGA
GCCTGCTCCTGCCGCCGAGGACATGGGTGTGGAGGCAAAGAACCATGA
AGTACACAACAGCCACAGGAAG
AAACATTACCAAGGTCCTCATTGCAAACAGAGGAGAA
ATTGCCTGCAGGGTGATGCGCACAGCCAAAAAA
CTGGGTGTACAGACTGTGGCGGTTTA
TAGTGAGGCTGACAGAAATTCCATGCATGTAGATATGGCAGATG
AAGCATATTCCATCG
GCCCCGCTCCCTCCCAGCAGAGCTACCTATCTATGGAGAAAATCATTCAAGTGGC
CAAG
ACCTCTGCTGCACAGGCTATCCATCCAGGATGCGGTTTTCTTTCAGAAAACATGGAATTT
GCTGAA
CTTTGTAAGCAAGAAGGAATTATTTTTATAGGCCCTCCTCCATCTGCAATTAG
AGACATGGGTATAAAGA
GCACATCCAAATCCATAATGGCTGCTGCTGGAGTACCTGTTG
TGGAGGGTTATCATGGTGAGGACCAATC
AGACCAGTGCCTGAAGGAACACGCCAGGAGA
ATTGGCTATCCTGTCATGATTAAAGCCGTCCGGGGTGGA
GGAGGAAAAGGAATGAGGAT
TGTTAGATCAGAACAAGAATTTCAAGAACAGTTAGAGTCAGCACGGAGAG
AAGCTAAGA
AGTCTTTCAATGATGATGCTATGCTGATCGAGAAGTTTGTAGACACACCGAGGCATGTAG
A
AGTCCAGGTGTTTGGTGATCACCATGGCAATGCTGTGTACTTGTTTGAAAGAGACTGT
AGTGTGCAGAGG
CGACATCAGAAGATCATTGAGGAGGCCCCAGCGCCTGGTATTAAATC
TGAAGTAAGAAAAAAGCTGGGAG
AAGCTGCAGTCAGAGCTGCTAAAGCTGTAAATTATG
TTGGAGCAGGGACTGTGGAGTTTATTATGGACTC
AAAACATAATTTCTGTTTCATGGAG
ATGAATACAAGGCTGCAAGTGGAACATCCTGTTACTGAGATGATC
ACAGGAACTGACTT
GGTGGAGTGGCAGCTTAGAATTGCAGCAGGAGAGAAGATTCCTTTGAGCCAGGAAG
AAA
TAACTCTGCAGGGCCATGCCTTCGAAGCTAGAATATATGCAGAAGATCCTAGCAATAACT
TCATGCC
TGTGGCAGGCCCATTAGTGCACCTCTCTACTCCTCGAGCAGACCCTTCCACC
AGGATTGAAACTGGAGTA
CGGCAAGGAGACGAAGTTTCCGTGCATTATGACCCCATGAT
TGCGAAGCTGGTCGTGTGGGCAGCAGATC
GCCAGGCGGCATTGACAAAACTGAGGTACA
GCCTTCGTCAGTACAATATTGTTGGACTGCACACCAACAT
TGACTTCTTACTCAACCTG
TCTGGCCACCCAGAGTTTGAAGCTGGGAACGTGCACACTGATTTCATCCCT
CAACACCA
CAAACAGTTGTTGCTCAGTCGGAAGGCTGCAGCCAAAGAGTCTTTATGCCAGGCAGCCCT
GG
GTCTCATCCTCAAGGAGAAAGCCATGACCGACACTTTCACTCTTCAGGCACATGATC
AATTCTCTCCATT
TTCGTCTAGCAGTGGAAGAAGACTGAATATCTCGTATACCAGAAAC
ATGACTCTTAAAGATGGTAAAAAC
AATGTAGCCATAGCTGTAACGTATAACCATGATGG
GTCTTATAGCATGCAGATTGAAGATAAAACTTTCC
AAGTCCTTGGTAATCTTTACAGCG
AGGGAGACTGCACTTACCTGAAATGTTCTGTTAATGGAGTTGCTAG
TAAAGCGAAGCTG
ATTATCCTGGAAAACACTATTTACCTATTTTCCAAGGAAGGAAGTATTGAGATTGAC
AT
TCCAGTCCCCAAATACTTATCTTCTGTGAGCTCACAAGAAACTCAGGGCGGCCCCTTAGC
TCCTATGA
CTGGAACCATTGAAAAGGTGTTTGTCAAAGCTGGAGACAAAGTGAAAGCGG
GAGATTCCCTCATGGTTAT
GATCGCCATGAAGATGGAGCATACCATAAAGTCTCCAAAG
GATGGCACAGTAAAGAAAGTGTTCTACAGA
GAAGGTGCTCAGGCCAACAGACACACTCC
TTTAGTCGAGTTTGAGGAGGAAGAATCAGACAAAAGGGAAT
CGGAATAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AF310972

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_4_Locus:
3q27

# Metabolic_Enzyme_4_SNPs:
rs35219417; rs2270968; rs7622479; rs937652; rs2270967; rs1540735; rs1995426; rs6443848; rs10212195; rs10937108; rs6443849; rs6771735; rs6801608; rs9882050; rs6785680; rs11928508; rs6806390; rs7611168; rs2270969; rs6443846; rs1995427; rs6443842; rs7640612; rs12491196; rs1502762; rs4859271; rs10937112; rs12486983; rs4859156; rs1604586; rs1566705; rs12497989; rs11712267; rs9861225; rs7632904; rs10513789; rs4859274; rs2134427; rs6782692; rs1540736; rs10937106; rs13326553; rs10937111; rs1056565; rs4859154; rs6786878; rs10804888; rs7432920; rs2292057; rs11917464; rs11917378; rs12638619; rs12637471; rs6806083; rs9822789; rs2292056; rs9877289; rs10937105; rs9812846; rs13078931; rs6443850; rs9838514; rs9823766; rs6772568; rs3732604; rs12495806; rs4859266; rs13322798; rs10513790; rs13322863; rs3772721; rs6443845; rs4859265; rs13097765; rs4859153; rs11927776; rs2292058; rs1948799; rs7624867; rs6801522; rs13088830; rs6443844; rs7614207; rs7613986; rs9879377; rs7637448; rs9834143; rs4859273; rs7629763; rs2314738; rs4859268; rs12496512; rs13072934; rs1910279; rs11716229; rs10937107; rs4859151; rs3772722; rs9821577; rs7649701; rs2872702; rs11926525; rs13075596; rs12636930; rs4859267; rs1970864; rs9861464; rs6806354; rs6780763; rs2314737; rs13075011; rs9877655; rs12634147; rs12495766; rs12498020; rs11708689; rs1910280; rs4859276; rs13061424; rs1970863; rs7433755; rs13066020; rs7629760; rs11927250; rs11711666; rs16833689; rs9810968; rs4859264; rs7622140; rs7615536; rs4859275; rs7646991; rs6443843; rs9290752; rs7623700; rs7652556; rs1135365; rs6443840; rs1547910; rs7615451; rs4859262; rs9290751; rs9290750; rs4859150; rs7618801; rs6443851; rs35706839; rs36206712; rs34749281; rs11540930; rs41265429; rs35110907; rs34449442; rs34467860; rs35938218; rs35900486; rs35742027; rs6789698; rs11324054; rs28589465; rs11423070; rs3056488; rs34297292; rs12632373; rs11373462; rs34715234; rs4859263; rs7651093; rs6443847; rs28413605; rs10663232; rs35283773; rs34895943; rs4859269; rs11313652; rs17541829; rs35587538; rs10571331; rs13059375; rs10637737; rs28366717; rs35071527; rs12330492; rs35177725; rs11411314; rs28575398; rs34472753; rs34126309; rs34937697; rs34971116; rs34161676; rs7622965; rs28427471; rs6805277; rs10937110; rs10704597; rs4859270; rs34793741; rs34873451; rs35348780; rs28793315; rs16833679; rs11329735; rs36099251; rs34822404; rs10937109; rs11426247; rs36062669; rs4859272; rs34723716; rs4859155; rs41265427; rs11463635; rs35914626; rs16833681; rs4380436; rs35493081; rs28708863; rs34409416; rs35702045; rs10692178; rs34601027; rs34254014; rs34132711; rs7616810; rs35356364; rs34962125; rs13326155; rs35554340; rs34484607; rs35294219; rs6806155; rs10709578; rs11433120; rs36037059; rs5015387; rs34422438; rs4859152; rs9876859; rs35192508; rs34319336; rs6769550; rs6766367; rs6785198; rs34764997; rs10580342; rs35330892; rs34882766; rs6806512; rs34130252; rs34643375; rs10669856; rs33937574; rs6777617; rs36107560; rs34943658; rs28364748; rs35853083; rs35081437; rs11710342; rs11714270; rs11921003; rs12496089; rs4074110; rs4074310; rs4241561; rs6762373; rs6762726; rs6764058; rs6773022; rs6791884; rs7618830; rs7621434; rs7635560; rs9841498; rs9858038; rs9877549

# Metabolic_Enzyme_4_General_References:
11401427; 11406611; 11181649

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5490

# Metabolic_Enzyme_5_Name:
Propionyl-CoA carboxylase beta chain, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta

# Metabolic_Enzyme_5_Gene_Name:
PCCB

# Metabolic_Enzyme_5_Protein_Sequence:
>PropionylCoA carboxylase beta chain, mitochondrial precursor
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHK
RGKLTARERI
SLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLV
YVFSQDFTVFGGSLSGAHAQK
ICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYAD
IFLRNVTASGVIPQISLIMGPCAGGAVYSPAL
TDFTFMVKDTSYLFITGPDVVKSVTNE
DVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPL
SSQDPAPVRECHDPSD
RLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGR
TVGIV
GNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKL
LYAFA
EATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFK
GHENVEAAQAEYIEKF
ANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRK
HANIPL

# Metabolic_Enzyme_5_Number_of_Residues:
539

# Metabolic_Enzyme_5_Molecular_Weight:
58216

# Metabolic_Enzyme_5_Theoretical_pI:
7.69

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_5_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_5_Reaction:
ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01039:Carboxyl_trans

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 6.4.1.3

# Metabolic_Enzyme_5_GenBank_ID_Protein:
312812

# Metabolic_Enzyme_5_SwissProt_ID:
PCCB_HUMAN (P05166)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PCCB

# Metabolic_Enzyme_5_Geneatlas_id:
PCCB

# Metabolic_Enzyme_5_hgnc_id:
HGNC:8654

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_5_Gene_Sequence:
>1620 bp

ATGGCGGCGGCATTACGGGTGGCGGCGGTCGGGGCAAGGCTCAGCGTTCTGGCGAGCGG
TCTCCGCGCCG
CGGTCCGCAGCCTTTGCAGCCAGGCCACCTCTGTTAACGAACGCATCG
AAAACAAGCGCCGGACCGCGCT
GCTGGGAGGGGGCCAACGCCGTATTGACGCGCAGCAC
AAGCGAGGAAAGCTAACAGCCAGGGAGAGGATC
AGTCTCTTGCTGGACCCTGGCAGCTT
TGTTGAGAGCGACATGTTTGTGGAACACAGATGTGCAGATTTTG
GAATGGCTGCTGACA
AGAATAAGTTTCCTGGAGACAGCGTGGTCACTGGACGAGGCCGAATCAATGGAAG
ATTG
GTTTATGTCTTCAGTCAGGATTTTACAGTTTTTGGAGGCAGTCTGTCAGGAGCACATGCC
CAAAAG
ATCTGCAAAATCATGGACCAGGCCATAACGGTGGGGGCTCCAGTGATTGGGCT
GAATGACTCTGGGGGAG
CACGGATCCAAGAAGGAGTGGAGTCTTTGGCTGGCTATGCAG
ACATCTTTCTGAGGAATGTTACGGCATC
CGGAGTCATCCCTCAGATTTCTCTGATCATG
GGCCCATGTGCTGGTGGGGCCGTCTACTCCCCAGCCCTA
ACAGACTTCACGTTCATGGT
AAAGGACACCTCCTACCTGTTCATCACTGGCCCTGATGTTGTGAAGTCTG
TCACCAATG
AGGATGTTACCCAGGAGGAGCTCGGTGGTGCCAAGACCCACACCACCATGTCAGGTGTGG
C
CCACAGAGCTTTTGAAAATGATGTTGATGCCTTGTGTAATCTCCGGGATTTCTTCAAC
TACCTGCCCCTG
AGCAGTCAGGACCCGGCTTCCGTCCGTGAGTGCCACGATCCCAGTGA
CCGTCTGGTTCCTGAGCTTGACA
CAATTGTCCCTTTGGAATCAACCAAAGCCTACAACA
TGGTGGACATCATACACTCTGTTGTTGATGAGCG
TGAATTTTTTGAGATCATGCCCAAT
TATGCCAAGAACATCATTGTTGGTTTTGCAAGAATGAATGGGAGG
ACTGTTGGAATTGT
TGGCAACCAACCTAAGGTGGCCTCAGGATGCTTGGATATTAATTCATCTGTGAAAG
GGG
CTCGTTTTGTCAGATTCTGTGATGCATTCAATATTCCACTCATCACTTTTGTTGATGTCC
CTGGCTT
TCTACCTGGCACAGCACAGGAATACGGGGGCATCATCCGGCATGGTGCCAAG
CTTCTCTACGCATTTGCT
GAGGCAACTGTACCCAAAGTCACAGTCATCACCAGGAAGGC
CTATGGAGGTGCCTATGATGTCATGAGCT
CTAAGCACCTTTGTGGTGATACCAACTATG
CCTGGCCCACCGCAGAGATTGCAGTCATGGGAGCAAAGGG
CGCTGTGGAGATCATCTTC
AAAGGGCATGAGAATGTGGAAGCTGCTCAGGCAGAGTACATCGAGAAGTTT
GCCAACCC
TTTCCCTGCAGCAGTGCGAGGGTTTGTGGATGACATCATCCAACCTTCTTCCACACGTGC
CC
GAATCTGCTGTGACCTGGATGTCTTGGCCAGCAAGAAGGTACAACGTCCTTGGAGAA
AACATGCAAATAT
TCCATTGTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X73424

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_5_Locus:
3q21-q22

# Metabolic_Enzyme_5_SNPs:
rs1711171; rs1153877; rs9844666; rs6776841; rs7622833; rs548288; rs1279425; rs2290131; rs1279086; rs553018; rs632016; rs650326; rs696081; rs4678428; rs664088; rs576771; rs650505; rs1279840; rs7650071; rs1279424; rs9872326; rs665200; rs9843348; rs6774573; rs7626889; rs17252498; rs6796523; rs12695645; rs4484145; rs684195; rs12492830; rs838202; rs681783; rs1618069; rs589092; rs9843801; rs483465; rs12488721; rs9853387; rs9826146; rs3821445; rs9833162; rs7653249; rs9289507; rs9289506; rs9835482; rs7633476; rs1279950; rs7622929; rs16843918; rs16843892; rs16843879; rs7615203; rs6785225; rs1291921; rs6808143; rs7611416; rs9848883; rs9866840; rs489398; rs7633573; rs11713514; rs12330635; rs6765839; rs6807002; rs9856769; rs3732520; rs9809806; rs2305265; rs518972; rs7615199; rs7615252; rs17265675; rs9829390; rs676237; rs1711170; rs13090330; rs3732521; rs3732519; rs7611507; rs16843829; rs16843806; rs3755636; rs28934887; rs1130114; rs2686559; rs35923895; rs11434447; rs2948153; rs13099771; rs1300031; rs1698984; rs598989; rs556788; rs552098; rs34350990; rs3994934; rs865113; rs7430820; rs11276589; rs570621; rs3913715; rs11421458; rs13067714; rs28848266; rs519766; rs35915403; rs598576; rs711979; rs2971555; rs1720751; rs586381; rs35875406; rs863900; rs1698983; rs10602343; rs9864912; rs11715586; rs1711167; rs480330; rs34690853; rs34167145; rs34943743; rs34551310; rs35316359; rs10524213; rs7613584; rs2689386; rs1298857; rs34031772; rs11916366; rs866782; rs4678429; rs7642585; rs13068199; rs34066658; rs33956304; rs11719796; rs675335; rs9884075; rs680487; rs12330421; rs9812837; rs641415; rs1292281; rs515181; rs2971556; rs12163608; rs36106592; rs2689389; rs517847; rs1279949; rs521775; rs34417976; rs34673387; rs35507003; rs10576866; rs35790151; rs34160582; rs13071533; rs35871807; rs7628146; rs34362321; rs6148083; rs1612376; rs34481240; rs11707791; rs865668; rs28804502; rs35786833; rs1279962; rs9834054; rs35524055; rs34349947; rs610691; rs1097472; rs34947225; rs34864084; rs1711166; rs1667321; rs35582341; rs2971557; rs34864587; rs35322388; rs4317048; rs2103087; rs34976823; rs7618114; rs34038836; rs9872178; rs11385401; rs35681043; rs2971554; rs606725; rs34409113; rs1300014; rs674902; rs1299252; rs1298842; rs34354052; rs35633718; rs34303028; rs36123354; rs35144965; rs13072038; rs3884120; rs35522825; rs4125861; rs1316208; rs4383459; rs865667; rs35228700; rs34511849; rs3994953; rs9852811; rs34106072; rs34726739; rs35227703; rs34153877; rs35942146; rs28812220; rs34428695; rs9871320; rs34974143; rs12633129; rs1300032; rs9872091; rs13071085; rs1720752; rs13067567; rs677825; rs527888; rs35529413; rs34146770; rs35838767; rs10513002; rs11926660; rs13785; rs17199880; rs17199978; rs3894140; rs534944; rs561307; rs610860; rs6439638; rs6783337; rs696520; rs7626261; rs8045; rs9812513

# Metabolic_Enzyme_5_General_References:
8188292; 8225321; 9683601; 3460076; 2154743; 8411997; 10447268; 10502773; 12559849

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5276

# Metabolic_Enzyme_6_Name:
Acetyl-CoA carboxylase 1

# Metabolic_Enzyme_6_Synonyms:
ACC-alpha[Includes: Biotin carboxylase

# Metabolic_Enzyme_6_Gene_Name:
ACACA

# Metabolic_Enzyme_6_Protein_Sequence:
>AcetylCoA carboxylase 1
MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLS
DLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEK
VLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG
GPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWAL
GDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQA
AEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEV
QILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA
GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMY
GVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGY
FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLET
ESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQV
LPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDG
SSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYA
EIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ
STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQ
DIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREV
FFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSD
MNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALR
ARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYH
SNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRM
SFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP
PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLV
DHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQ
LELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFE
YLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYG
SRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQA
YGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQA
FLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI
GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVD
PEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGS
GMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGR
EVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPID
RIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGG
IPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPL
MVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI
NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAE
RKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLR
RLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTE
EDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILST
MDSPST

# Metabolic_Enzyme_6_Number_of_Residues:
2346

# Metabolic_Enzyme_6_Molecular_Weight:
265557

# Metabolic_Enzyme_6_Theoretical_pI:
6.32

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

# Metabolic_Enzyme_6_Pathway:
map00061  Fatty acid biosynthesis (path 1);
 map00253  Tetracycline biosynthesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_6_Reaction:
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF08326:ACC_central;
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF01039:Carboxyl_trans;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.4.1.2;EC 6.3.4.14

# Metabolic_Enzyme_6_GenBank_ID_Protein:
849083

# Metabolic_Enzyme_6_SwissProt_ID:
COA1_HUMAN (Q13085)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ACACA

# Metabolic_Enzyme_6_Geneatlas_id:
ACACA

# Metabolic_Enzyme_6_hgnc_id:
HGNC:84

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>7041 bp
ATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGCTGAACCAGCACTCTCGATTCATA
ATAGGTTCTGTGTCAGAAGATAACTCAGAGGATGAGATCAGCAACCTGGTGAAGCTGGAC
CTACTGGAGGAGAAGGAGGGCTCCTTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCT
GATTTGGGGATCTCTGCCCTACAGGATGGCTTGGCCTTGCACATAAGGTCCAGCTGGTCT
GGCTTGCACCTAGTAAAGCAGGGCGGAGACAGAAAGAAAATAGATTCTCAACGAGATTTC
ACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAGTGATTGAGAAG
GTTCTCATCGCTAACAATGGCATTGCAGCAGTGAAATGCATGCGGTCTATCCGTAGGTGG
TCTTATGAAATGTTTCGAAATGAACGTGCAATTAGATTCGTTGTCATGGTCACACCTGAA
GACCTTAAAGCCAATGCAGAATACATTAAGATGGCAGATCACTATGTGCCGGTGCCTGGA
GGAGCAAACAACAACAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATC
CCAGTGCAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACCGGAA
CTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAACCAGGCCATGTGGGCTTTA
GGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTGCAGGTATCCCAACTCTTCCCTGG
AGCGGCAGTGGTCTTCGTGTGGACTGGCAGGAAAATGATTTTTCAAAACGTATCTTAAAT
GTTCCCCAGGAGCTATATGAAAAAGGTTATGTGAAAGATGTGGATGATGGGCTAAAGGCA
GCTGAGAAGGTTGGATATCCAGTAATGATCAAGGCCTCAGAGGGAGGAGGAGGGAAGGGA
ATTAGAAAAGTTAACAATGCAGATGACTTCCCTAATCTCTTCAGACAGGTTCAAGCTGAA
GTTCCTGGATCTCCCATATTTGTGATGAGACTAGCCAAACAATCTCGTCATCTGGAGGTG
CAGATCTTAGCGGACCAATATGGCAATGCTATCTCTTTGTTTGGTCGTGATTGCTCTGTA
CAACGCAGGCATCAGAAGATTATTGAAGAAGCACCTGCTACTATTGCTACTCCAGCAGTA
TTTGAACACATGGAACAGTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCT
GGGACTGTGGAATACCTGTACAGCCAGGATGGCAGCTTCTACTTTCTAGAATTGAACCCT
CGGCTACAGGTTGAACAACCTTGTACAGAGATGGTGGCTGATGTCAATCTCCCCGCAGCA
CAGCTCCAGATTGCCATGGGGATTCCTCTATATAGAATCAAGGATATCCGTATGATGTAT
GGGGTATCTCCTTGGGGTGATTCTCCCATTGATTTTGAAAATTCTGCTCACGTTCCTTGT
CCAAGGGGCCATGTTATTGCTGCTCGGATCACTAGTGAAAATCCAGATGAGGGTTTTAAG
CCCAGCTCAGGAACAGTTCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATAT
TTCAGTGTTGCTGCTGCAGGGGGACTTCATGAATTTGCTGGTTCTCAGTTTGGTCACTGC
TTTTCTTGGGGAGAAAACAGAGAAGAAGCAATTTCAAACATGGTGGTGGCATTGAAGGAG
CTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACT
GAAAGCTTTCAAATGAACAGAATTGATACTGGCTGGCTGGACAGACTGATAGCAGAAAAA
GTACGGGCTGAGCGTCCTGACACCATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTCGGA
GATGTGAGCCTGCGAAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTC
CTTCCGGCTCATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTCAAG
TATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATCATGAATGGCTCA
TGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGC
AGCAGTTACACCACGTATATGAAGGAGGAAGTAGACAGATATCGCATCACAATTGGCAAT
AAAACCTGTGTGTTTGAGAAGGAAAATGACCCATCGGTGATGCGCTCACCTTCTGCTGGG
AAGTTAATCCAGTACATTGTAGAAGATGGAGGTCATGTGTTTGCCGGCCAGTGCTATGCA
GAGATTGAGGTAATGAAGATGGTAATGACTTTGACAGCTGTGGAGTCTGGCTGTATCCAT
TACGTCAAGCGTCCTGGAGCAGCTCTTGACCCTGGCTGTGTACTCGCCAAAATGCAACTG
GACAACCCCAGCAAGGTTCAGCAGGCTGAACTTCACACAGGTAGTCTGCCACGGATCCAG
AGCACCGCTCTCCGAGGCGAGAAGCTCCATCGAGTGTTCCACTATGTCCTGGATAATCTG
GTCAATGTAATGAATGGATACTGCCTTCCAGATCCTTTCTTTAGCAGCAAGGTAAAAGAC
TGGGTAGAACGATTGATGAAAACCCTCAGAGATCCCTCCCTGCCTCTCCTAGAATTGCAA
GATATTATGACCAGTGTGTCTGGCCGCATTCCCCCCAATGTGGAGAAGTCTATCAAGAAG
GAAATGGCTCAGTATGCTAGCAACATCACATCAGTCCTCTGTCAGTTTCCCAGCCAGCAG
ATTGCAAACATCCTAGATAGCCATGCAGCTACATTGAACCGGAAATCTGAACGGGAAGTC
TTCTTTATGAATACTCAGAGCATTGTCCAGCTGGTACAGAGGTACCGAAGTGGCATCCGA
GGCCACATGAAGGCTGTGGTGATGGATCTGCTCCGGCAGTACCTGCGAGTAGAGACACAA
TTCCAGAATGGTCACTATGACAAATGTGTATTCGCCCTTCGAGAAGAGAATAAGAGTGAC
ATGAACACTGTACTGAACTACATCTTCTCTCACGCTCAAGTCACCAAGAAGAATCTTCTG
GTCACAATGCTTATTGATCAGTTGTGTGGCCGGGACCCTACTCTAACTGATGAGCTGCTG
AGTATTCTCACAGAGCTAACTCAACTCAGTAAGACCACCAATGCCAAAGTAGCACTTCGA
GCACGCCAGGTTCTTATTGCCTCCCATTTGCCATCATATGACGTTCGCCATAACCAAGTA
GAGTCTATCTTCCTATCAGCTATTGACATGTATGGACATCAATTTTGCATTGAGAACCTG
CAGAAACTCATCCTATCAGAAACATCTATTTTTGATGTCCTACCAAACTTCTTCTATCAC
AGCAACCAAGTAGTGAGGATGGCAGCTCTGGAGGTGTACGTTCGAAGGGCTTATATTGCC
TATGAACTTAACAGCGTACAACACCGCCAGCTTAAGGACAACACCTGCGTGGTGGAATTC
CAGTTCATGCTGCCCACATCTCATCCAAACAGAGGGAACATCCCTACGCTAAACAGAATG
TCCTTCTCCTCCAACCTCAACCACTATGGCATGACCCATGTAGCTAGTGTCAGCGATGTT
CTGTTGGACAACGCCTTCACACCACCTTGTCAACGCATGGGCGGAATGGTCTCTTTTCGG
ACTTTTGAAGATTTTGTCAGGATCTTTGATGAAGTAATGGGCTGCTTCTGTGACTCCCCA
CCCCAGAGTCCCACATTCCCTGAGGCAGGTCACACGTCTCTTTATGATGAGGATAAGGTT
CCCAGGGATGAACCAATTCACATTCTCAATGTGGCTATCAAGACTGACGGTGATATTGAG
GATGACAGGCTGGCAGCTATGTTCAGAGAATTCACCCAGCAAAATAAAGCTACCCTGGCT
GACCATGGGATCCGGCGCCTGACTTTCCTGGTTGCACAAAAGGATTTCAGAAAGCAGGTC
AACTATGAGGTGGATCGGAGATTTCATAGAGAATTCCCTAAATTTTTTACATTCCGAGCA
AGGGATAAGTTTGAGGAGGATCGTATCTATCGTCATCTGGAGCCTGCTCTGGCTTTCCAG
TTAGAGCTGAACCGGATGAGAAATTTTGACCTCACTGCCATTCCATGTGCTAATCACAAG
ATGCACCTGTATCTCGGGGCAGCCAAGGTGGAAGTGGGCACAGAAGTGACAGACTACAGG
TTCTTTGTTCGTGCAATCATCAGGCATTCTGATCTGGTCACCAAGGAAGCTTCTTTTGAA
TATCTGCAAAGTGAAGGGGAGCGGCTACTCCTGGAAGCCATGGATGAGTTGGAAGTTGCT
TTTAACAATACAAATGTCCGCACTGACTGTAACCACATCCTCCTCAACTTTGTGCCCACG
GTTATCATGGACCCATCAAAGATTGAGGAATCCGTGCGGAGCATGGTAATGCGGTATGGA
AGTCGCCTGTGGAAATTGCGCGTCCTCCAGGCAGAACTGAAAATCAACATTCGCCTGACG
CCAACTGGAAAAGCAATTCCCATCCGCCTTTTCCTGACAAACGAGTCTGGCTATTACTTG
GATATCAGCCTATACAAGGAAGTGACTGACTCCAGGACAGCACAGATCATGTTTCAGGCA
TATGGAGACAAGCAGGGACCACTGCATGGAATGTTAATCAATACTCCATATGTGACCAAA
GACCTGCTGCAATCAAAGAGGTTCCAGGCACAATCCTTAGGGACAACGTACATATATGAT
ATCCCAGAGATGTTTCGGCAGTCCCTGATCAAACTCTGGGAGTCTATGTCAACTCAAGCA
TTTCTTCCATCTCCCCCTCTGCCTTCTGACATGCTGACTTACACTGAACTGGTACTGGAT
GATCAAGGTCAGCTGGTCCACATGAACAGGCTTCCAGGAGGAAATGAGATTGGCATGGTA
GCTTGGAAAATGAGCCTTAAAAGTCCTGAATATCCAGAAGGCCGAGATGTTATTGTTATT
GGCAATGACATTACATACCGAATTGGGTCCTTTGGGCCTCAAGAAGATTTGTTATTTCTC
AGAGCTTCCGAACTTGCTAGGGCCGAAGGCATTCCACGCATCTATGTATCAGCCAACAGT
GGAGCAAGAATCGGACTGGCAGAAGAAATTCGCCATATGTTTCATGTGGCCTGGGTAGAT
TCTGAGGATCCTTACAAGGGATACAGGTATTTATATCTGACTCCTCAAGATTATAAGAGA
GTCGGTGCTCTCAACTCTGTCCATTGTGAACACGTGGAAGATGAAGGAGAATCCAGGTAC
AAGATAACAGATATTATTGGGAAAGAAGAGGGAATTGGACCCGAGAACCTTCGAGGTTCT
GGAATGATCGCTGGAGAATCCTCATTGGCCTATAATGAGATCATTACCATCAGCCTGGTG
ACGTCCCGGGCCATTGGGATTGGGGCTTACCTTGTCCGGCTGGGACAGAGAACCATCCAG
GTTGAGAATTCTCACTTGATTCTAACAGGAGCTGGAGCCCTCAACAAAGTCCTCGGGCGG
GAAGTGTACACCTCCAATAACCAGCTGGGGGGCATCCAGATTACGCACAACAATGGGGTG
ACCCACTGCACTGTGTGTGACGGCTTTGAAGGGGTTTTCACTGTCCTGCACTGGCTGTCT
TACATGCCCAAGAGCGTACACAGTTCAGTTCCTCTTCTGAACTCAAAGGATCCTATAGAC
AGAATCATCGAGTTTGTTCCCACAAAGACCCCATATGATCCTCGATGGATGCTAGCAGGC
CGCCCTCACCCAACCCAAAAAGGTCAGTGGTTGAGTGGCTTTTTTGACTATGGATCTTTC
TCAGAGATTATGCAGCCCTGGGCACAGACGGTGGTGGTTGGTAGAGCCAGGTTAGGGGGA
ATACCTGTGGGAGTTGTTGCTGTAGAAACCCGGACAGTAGAACTAAGTGTACCAGCTGAT
CCAGCAAACCTGGATTCTGAAGCCAAGATAATCCAGCACGCCGGCCAAGTTTGGTTTCCG
GATTCTGCGTTTAAGACGTATCAGGCCATCAAGGACTTCAACCGGGAAGGGCTACCTCTA
ATGGTCTTTGCCAACTGGAGAGGCTTCTCTGGTGGAATGAAAGATATGTATCACCAAGTG
CTGAAGTTTGGTGCTTACATTGTGGATGGCTTGCGGGAATGTTCCCAGCCTGTGCTGGTC
TACATTCCTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATCGACCCAACCATC
AATCCTCGGCACATGGAGATGTATGCTGACCGAGAAAGCAGGGGATCTGTTCTGGAGCCA
GAAGGGACGGTAGAAATCAAATTCCGCAGAAAGGATCTGGTGAAAACCATGCGTCGGGTG
GACCCAGTCTACATCCACTTGGCTGAGCGATTGGGGACCCCAGAGCTGAGCCCAACTGAG
CGGAAGGAGTTGGAGAGCAAGTTGAAGGAGCGGGAGGAATTCCTAATTCCAATTTACCAT
CAGGTAGCCGTGCAGTTTGCTGACTTGCACGACACTCCAGGCCGGATGCAGGAGAAGGGT
GTTATTAGCGATATCCTGGATTGGAAAACATCCCGTACCTTCTTCTACTGGCGACTGAGG
CGTCTTCTGCTGGAGGACCTGGTCAAGAAGAAAATCCACAGTGCCAACCCTGAGCTGACT
GATGGCCAGATTCAAGCCATGTTAAGACGCTGGTTTGTGGAAGTGGAAGGAACAGTGAAG
GCTTATGTTTGGGACAATAATAAGGATCTGGCGGAGTGGCTAGAGAAACAGCTGACAGAG
GAGGATGGTGTTCACTCGGTAATAGAGGAAAACATCAAATGCATCAGCAGAGACTACGTC
CTCAAGCAAATCCGCAGCTTGGTCCAGGCCAATCCAGAGGTTGCCATGGATTCCATCATC
CATATGACGCAGCACATATCACCCACTCAGCGGGCAGAAGTCATAAGGATCCTTTCCACT
ATGGACTCCCCTTCTACGTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
U19822

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_6_Locus:
17q21

# Metabolic_Enzyme_6_SNPs:
rs2229416; rs2946342; rs1464255; rs878520; rs7216136; rs2542668; rs11656221; rs829168; rs1464257; rs829157; rs4795194; rs1464256; rs712038; rs2946537; rs12948120; rs1714996; rs954673; rs8076591; rs829160; rs9893734; rs829161; rs829156; rs12452294; rs2542666; rs2030314; rs6607369; rs829162; rs12451927; rs11869216; rs2049038; rs712037; rs7225031; rs17841479; rs1473626; rs9913481; rs9895936; rs1112174; rs8080851; rs12942424; rs8080375; rs8078306; rs17139041; rs8066509; rs9907598; rs8065658; rs8076589; rs9898293; rs9891762; rs4795193; rs2542670; rs829151; rs9898680; rs7223837; rs7222669; rs1715000; rs11871085; rs4500789; rs829167; rs17138792; rs11650095; rs11649798; rs7406300; rs7224009; rs9910658; rs8065811; rs9904519; rs2090603; rs7211305; rs12453651; rs7501676; rs11868780; rs9902736; rs9913542; rs8079644; rs9915232; rs12952401; rs7502962; rs1096038; rs8072619; rs2542665; rs1268567; rs2302800; rs2590728; rs1266182; rs2246459; rs2542653; rs2542660; rs1266180; rs895245; rs1878941; rs2680395; rs1900101; rs2121017; rs2898659; rs2255527; rs2542662; rs1266175; rs2680398; rs2017571; rs9286331; rs725038; rs2053670; rs11652379; rs9789070; rs9897583; rs2680392; rs9912138; rs2542663; rs11653028; rs11650464; rs3816309; rs2302803; rs7215365; rs9909876; rs9330250; rs4572453; rs2248509; rs7215615; rs3815059; rs1445487; rs9903451; rs8072064; rs10908287; rs7219583; rs6607364; rs2542659; rs7208613; rs9900363; rs7207026; rs9895998; rs9330249; rs9901601; rs2254914; rs1519091; rs4299194; rs7221404; rs8076694; rs3785948; rs12450937; rs2542655; rs7219671; rs12449696; rs4795190; rs4794753; rs12451365; rs2285655; rs8081866; rs7222524; rs11650327; rs7222727; rs2680400; rs9906543; rs11263823; rs9891423; rs2921368; rs17841492; rs2287352; rs4795181; rs9330251; rs7221195; rs11659129; rs2680399; rs9330248; rs4794750; rs7211430; rs11655013; rs2305097; rs17573357; rs7214025; rs10512477; rs11263824; rs2245093; rs2909264; rs8077266; rs2106772; rs3744589; rs11651239; rs12603098; rs11653093; rs7208053; rs11869869; rs2271855; rs12719988; rs2542654; rs11263825; rs12150477; rs17249662; rs17574651; rs4523972; rs9902961; rs9908334; rs12951598; rs2542661; rs9891027; rs17138930; rs7215485; rs2305099; rs17138934; rs3848462; rs4795189; rs2305098; rs10512478; rs12453407; rs12103832; rs1878942; rs2252757; rs3817376; rs34565612; rs17138898; rs12940254; rs2542652; rs7207912; rs1634334; rs7208404; rs4325613; rs8066577; rs7211788; rs4795182; rs8074739; rs4795172; rs2018578; rs2542656; rs12938125; rs9899403; rs9912155; rs1634335; rs4795177; rs12452907; rs8071957; rs17138899; rs2542664; rs8079975; rs11871055; rs1266183; rs12946127; rs17573893; rs8081936; rs2542657; rs17138804; rs2245066; rs2680394; rs2680402; rs8080705; rs9910098; rs7212022; rs7225778; rs9889428; rs4795180; rs9904710; rs8080136; rs17148; rs2049037; rs12945106; rs1266181; rs17138935; rs7224248; rs8078027; rs9914270; rs12603373; rs17695209; rs4795188; rs34196517; rs8079659; rs2680390; rs4795178; rs12603097; rs1266184; rs9910582; rs9652902; rs2278679; rs2542651; rs9915979; rs12601872; rs7208415; rs9899506; rs8072607; rs8071315; rs4473247; rs17652319; rs11263822; rs2680401; rs8071882; rs10153271; rs9915088; rs12601074; rs8082438; rs9895266; rs8068286; rs7221648; rs8068285; rs9893030; rs8068136; rs17841494; rs17138999; rs9630753; rs8072177; rs8078876; rs17139011; rs1634333; rs4795179; rs11867576; rs9899159; rs7502022; rs9905678; rs9906044; rs732770; rs17848757; rs17848759; rs2287351; rs1057349; rs1470452; rs2302802; rs1057347; rs1057348; rs1057350; rs8078349; rs4795192; rs1714623; rs35720275; rs9904194; rs3177098; rs11871196; rs2946344; rs11268107; rs28477683; rs12947290; rs11374277; rs1714619; rs11871581; rs9898204; rs35858056; rs9903488; rs5820211; rs1714994; rs9890038; rs11650629; rs5017481; rs35707017; rs7215677; rs35449295; rs8075744; rs7502476; rs35218514; rs9911273; rs8073540; rs35127394; rs7406337; rs34322212; rs1714999; rs35940399; rs11436121; rs34122401; rs36037660; rs34553247; rs9905514; rs35089144; rs12451158; rs11442383; rs9902122; rs35244497; rs10638342; rs35613288; rs1714614; rs1714628; rs7220707; rs12103707; rs11433722; rs35767845; rs35037307; rs35348805; rs34046448; rs34748698; rs9890298; rs34538373; rs5820212; rs2411158; rs35737118; rs9909611; rs12948635; rs2030285; rs8073434; rs12451423; rs35250857; rs35643626; rs7212437; rs12939217; rs34849930; rs35218812; rs12951107; rs3214149; rs11657433; rs1714622; rs35280698; rs35296298; rs12951195; rs35287948; rs853333; rs9912715; rs34732682; rs2542669; rs8064856; rs34680925; rs35438041; rs34937393; rs34068224; rs35921490; rs34937895; rs35348280; rs12938337; rs8080102; rs11452189; rs34866388; rs11291539; rs34308874; rs34550633; rs12939093; rs28601768; rs3197958; rs7350918; rs1714613; rs35610236; rs11653615; rs11327792; rs1102920; rs34530185; rs12944932; rs12945602; rs35059960; rs11409136; rs11557526; rs35451821; rs12945037; rs9914773; rs829158; rs35341859; rs34762337; rs11867736; rs865491; rs11871794; rs7502448; rs36034193; rs2680397; rs35040059; rs11658403; rs35046713; rs12952788; rs35309005; rs28621473; rs9900503; rs28559981; rs11658965; rs6607367; rs35706744; rs2285654; rs1112173; rs829159; rs11415508; rs35754179; rs17575843; rs35907016; rs2946343; rs1714624; rs34855609; rs5820210; rs34804632; rs7350920; rs1096037; rs35982452; rs1714998; rs2542667; rs34434804; rs12947603; rs11263826; rs7215696; rs12939724; rs829166; rs35728907; rs2898658; rs9906090; rs9903691; rs7213581; rs34384471; rs4795176; rs11654466; rs36094533; rs2542650; rs17848793; rs9890317; rs12942615; rs36093723; rs4570909; rs35053139; rs10645751; rs35471229; rs10671588; rs8076806; rs3841372; rs9898937; rs11347340; rs9915785; rs34671149; rs35248132; rs17848784; rs12949088; rs35230979; rs35061044; rs9900876; rs4795175; rs35956114; rs1271488; rs10568449; rs9674488; rs2411159; rs8075779; rs35737781; rs12947676; rs34458625; rs17848762; rs34182921; rs28477777; rs12941070; rs28698959; rs4510071; rs28528949; rs12949085; rs11303351; rs34482887; rs35220171; rs7212002; rs35538188; rs7214764; rs35098874; rs1634339; rs34489372; rs34997067; rs17848797; rs12942721; rs17848788; rs34367681; rs1664309; rs9914608; rs11299899; rs939129; rs36021448; rs35499336; rs35872142; rs5820208; rs12939415; rs17848771; rs3049593; rs12951401; rs35332296; rs35493433; rs11399349; rs10671587; rs2542658; rs1634340; rs11655089; rs11336184; rs35050543; rs35959861; rs11656682; rs35181821; rs35888166; rs34622871; rs1052813; rs8066905; rs34848337; rs34889497; rs35120204; rs1269928; rs34019734; rs28718742; rs11344097; rs7221916; rs36041619; rs17848758; rs28715486; rs12936609; rs6607365; rs34165656; rs10690897; rs2590729; rs3896990; rs35784797; rs11658519; rs34419580; rs9907032; rs2680393; rs5011489; rs1664313; rs2440930; rs9909663; rs35278959; rs34556010; rs36038126; rs7224720; rs11316017; rs12162164; rs8069192; rs35944181; rs35601261; rs9909209; rs34982826; rs34820331; rs36029062; rs34711647; rs12951295; rs10668354; rs35110941; rs17848785; rs11869067; rs28758642; rs35803116; rs1664312; rs9789078; rs7503749; rs4283266; rs4795173; rs28469706; rs7218958; rs12936483; rs17848760; rs12451360; rs12937002; rs34788014; rs28433321; rs3914775; rs35990848; rs11380975; rs34325998; rs2946338; rs9896763; rs33998928; rs17848782; rs10631083; rs1272399; rs11872016; rs1664308; rs9916468; rs12938356; rs11454831; rs12601087; rs34202919; rs34870931; rs34045470; rs36040010; rs35115636; rs11658482; rs1664307; rs34200410; rs9897866; rs9891120; rs7222011; rs35381652; rs34417650; rs17848773; rs12937687; rs11449332; rs36012737; rs28601670; rs1664310; rs34867690; rs35646199; rs10552606; rs35904405; rs17848777; rs34828277; rs35067909; rs17848791; rs17848779; rs34360478; rs34819116; rs34347402; rs35596715; rs28637322; rs1634336; rs35355755; rs5820207; rs12949895; rs11415930; rs1634341; rs3049582; rs9891493; rs35820505; rs9914412; rs10533480; rs10531552; rs34797415; rs28422855; rs36094882; rs9914097; rs4395121; rs12949666; rs2218492; rs34390024; rs35212343; rs10528744; rs11399968; rs12949301; rs1829409; rs12373130; rs4795184; rs35895326; rs12603225; rs35132757; rs35607802; rs34376457; rs28407410; rs11387933; rs34462409; rs9709110; rs35355558; rs34324549; rs4141321; rs11655124; rs4794751; rs35480307; rs12949893; rs34204061; rs1269929; rs11353672; rs12948010; rs11290127; rs35902268; rs34687448; rs17848794; rs35051577; rs10559180; rs36049042; rs11655018; rs9896459; rs10671586; rs10533479; rs5820209; rs35953832; rs1664311; rs12162162; rs2590727; rs4794752; rs4795174; rs17841491; rs9889809; rs28690443; rs34915260; rs17848765; rs34202102; rs17848792; rs35340914; rs5820206; rs1664306; rs17848781; rs1634337; rs28562944; rs12943917; rs1634342; rs2302801; rs8081655; rs11276038; rs35654179; rs2680391; rs34347667; rs35927365; rs7216802; rs34888479; rs28479986; rs4794749; rs35005664; rs28729196; rs34064045; rs4313849; rs17848775; rs34370484; rs9908693; rs3217177; rs28536028; rs34847496; rs34102178; rs35977079; rs36105403; rs12938721; rs12947675; rs34306905; rs10664252; rs4795170; rs28481702; rs1634338; rs9913086; rs34260630; rs34732750; rs11649942; rs12950056; rs34587818; rs9891491; rs2411160; rs17848783; rs35737566; rs34799022; rs35653728; rs7215793; rs11655157; rs35123372; rs12942719; rs2680396; rs1822944; rs11353673; rs35748619; rs12943201; rs8079157; rs11315644; rs12950440; rs5820205; rs34978266; rs36103499; rs1046873; rs11656455; rs11867460; rs11871275; rs12601443; rs12938498; rs1681809; rs17138766; rs1714986; rs1714987; rs1822941; rs1822942; rs1822943; rs2005356; rs2005357; rs2411161; rs2946340; rs34232224; rs7211875; rs7224522; rs8066442; rs8068303; rs8073074; rs8082190; rs829163; rs829164; rs829165; rs873409; rs873410; rs9890344; rs9916113

# Metabolic_Enzyme_6_General_References:
7732023; 12810950

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5817

# Metabolic_Enzyme_7_Name:
Biotinidase precursor

# Metabolic_Enzyme_7_Synonyms:
Not Available

# Metabolic_Enzyme_7_Gene_Name:
BTD

# Metabolic_Enzyme_7_Protein_Sequence:
>Biotinidase precursor
MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQ
EALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRW
NPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVF
SNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRD
YKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESF
WYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHC
DEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYAL
GVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFL
TSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

# Metabolic_Enzyme_7_Number_of_Residues:
523

# Metabolic_Enzyme_7_Molecular_Weight:
58914

# Metabolic_Enzyme_7_Theoretical_pI:
5.72

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

# Metabolic_Enzyme_7_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_7_Reaction:
biotin amide + H2O = biotin + NH3

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_7_Signals:
1-21

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.1.12

# Metabolic_Enzyme_7_GenBank_ID_Protein:
468824

# Metabolic_Enzyme_7_SwissProt_ID:
BTD_HUMAN (P43251)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
BTD

# Metabolic_Enzyme_7_Geneatlas_id:
BTD

# Metabolic_Enzyme_7_hgnc_id:
HGNC:1122

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_7_Gene_Sequence:
>1632 bp
ATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATT
ATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTG
GGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCT
GCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAA
GAGGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCA
GCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAACTTT
ACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGG
AACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGCTCCAGCGCCTGAGTTGT
ATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCTTGTCAT
AGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTC
AGCAATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCA
TTCGATGTTCCTCTTAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTT
GGCATCTTCACATGCTTTGATATATTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGAC
TACAAGGTGAAGCATGTTGTGTACCCAACTGCCTGGATGAACCAGCTCCCACTCTTGGCA
GCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAACGTTCTGGCAGCTAAT
GTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAGTCCTTT
TGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAAT
CCAGTGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAG
TTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGT
GATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTAT
GACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAAT
GGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTG
GGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTG
GTCAGGTGTGGGGGTCTTGGCTTCGACACCTGCGGACAGGAAATCACAGAGGCCACGGGG
ATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTG
ACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTC
CTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTAT
GAGAGGGACTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U03274

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_7_Locus:
3p25

# Metabolic_Enzyme_7_SNPs:
rs35034250; rs13078881; rs3817641; rs924814; rs2471809; rs2455826; rs4094397; rs2455820; rs9853116; rs2455810; rs1021849; rs2455916; rs9880034; rs4478067; rs2280770; rs13320591; rs760066; rs2471807; rs11128749; rs7651039; rs6773682; rs2455827; rs2470526; rs12489825; rs2455823; rs2470529; rs2455915; rs10510441; rs13319547; rs741747; rs741748; rs9858977; rs9310480; rs9866477; rs1296433; rs2734308; rs9858784; rs7640807; rs34356435; rs9310481; rs9849809; rs10212184; rs12330387; rs7621332; rs4626087; rs9827673; rs4309707; rs9825546; rs2455828; rs9310479; rs9830528; rs17041367; rs2470551; rs12639040; rs6807875; rs9836533; rs2174267; rs28934601; rs35976361; rs13073139; rs34885143; rs35145938; rs28475858; rs28612795; rs2055564; rs9838247; rs13066152; rs12494340; rs11714810; rs34101231; rs34976221; rs11916854; rs2471806; rs4298027; rs2470528; rs2455918; rs6803821; rs12493340; rs35141065; rs35452512; rs2470541; rs2654647; rs12631444; rs2455825; rs13068169; rs9873582; rs13075998; rs35719864; rs4685254; rs2734309; rs35863533; rs35004427; rs10621505; rs28576968; rs36065590; rs11915606; rs12330789; rs4407396; rs11717801; rs13088542; rs9755; rs35369543; rs7620644; rs9825684; rs4582034; rs35742912; rs28450862; rs28758269; rs34826323; rs7429324; rs2470527; rs13099874; rs35741795; rs34655059; rs9867921; rs36018115; rs2455822; rs2455824; rs28374257; rs6800368; rs1504098; rs1875798; rs2455917; rs9882597; rs11369757; rs11405819; rs6773959; rs35402548; rs9838246; rs34597886; rs36078683; rs35244780; rs2455821; rs35735277; rs9847991; rs9840496; rs34143777; rs34795748; rs2280771; rs12488812; rs34408221; rs28553993; rs9868928; rs9870498; rs35638740; rs13061544; rs34718841; rs35175965; rs2470525; rs4684257; rs36053401; rs11918810; rs12490588; rs13076664; rs13076834; rs13076843; rs13099347; rs1504099; rs2004783; rs2014933; rs2019160; rs2089054; rs2134784; rs2279841; rs2455852; rs2455853; rs2455854; rs2470530; rs2470531; rs2470532; rs2734307; rs3732720; rs3796302; rs3796305; rs6773994; rs6784844; rs6804782; rs7626148; rs869569; rs905555; rs9647358; rs9830541; rs9834785; rs9879788

# Metabolic_Enzyme_7_General_References:
7509806; 9530634; 9099842; 9654207

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5491

# Metabolic_Enzyme_8_Name:
Propionyl-CoA carboxylase alpha chain, mitochondrial precursor

# Metabolic_Enzyme_8_Synonyms:
PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha

# Metabolic_Enzyme_8_Gene_Name:
PCCA

# Metabolic_Enzyme_8_Protein_Sequence:
>PropionylCoA carboxylase alpha chain, mitochondrial precursor
MLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKM
GIKTVAIHSD
VDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYG
FLSENKEFARCLAAEDVVFIG
PDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAE
EAVRIAREIGYPVMIKASAGGGGKGMRIAWDD
EETRDGFRLSSQEAASSFGDDRLLIEK
FIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPS
IFLDAETRRAMGEQAV
ALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIR
VAKGY
PLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSD
ISIYY
DPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDI
STKFLSDVYPDGFKGH
MLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIAN
WELSVKLHDKVHTVVASNNGSVFSVEV
DGSKLNVTSTWNLASPLLSVSVDGTQRTVQCL
SREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVT
EDTSSVLRSPMPGVVVAVSVK
PGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLV
ELE

# Metabolic_Enzyme_8_Number_of_Residues:
703

# Metabolic_Enzyme_8_Molecular_Weight:
77355

# Metabolic_Enzyme_8_Theoretical_pI:
7.07

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
ATP + propanoyl-CoA + HCO(3)(-) = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_8_Pathway:
map00280  Valine, leucine and isoleucine degradation;
 map00640  Propanoate metabolism

# Metabolic_Enzyme_8_Reaction:
ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.4.1.3

# Metabolic_Enzyme_8_GenBank_ID_Protein:
296366

# Metabolic_Enzyme_8_SwissProt_ID:
PCCA_HUMAN (P05165)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
PCCA

# Metabolic_Enzyme_8_Geneatlas_id:
PCCA

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8653

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_8_Gene_Sequence:
>2112 bp

ATGCTGAGCGCGGCGCTGCGGACCCTGAAGCATGTTCTGTACTATTCAAGACAGTGCTT
AATGGTGTCCC
GTAATCTTGGTTCAGTGGGATATGATCCTAATGAAAAAACTTTTGATA
AAATTCTTGTTGCTAATAGAGG
AGAAATTGCATGTCGGGTTATTAGAACTTGCAAGAAG
ATGGGCATTAAGACAGTTGCCATCCACAGTGAT
GTTGATGCTAGTTCTGTTCATGTGAA
AATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTA
AAAGCTACCTCAACA
TGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCTGTACATCCAGG
TTAT
GGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTGGCAGCAGAAGATGTCGTTTTC
ATTGGA
CCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTGAAAGCAAATTATT
AGCTAAGAAAGCAGAGG
TTAATACAATCCCTGGCTTTGATGGAGTAGTCAAGGATGCAG
AAGAAGCTGTCAGAATTGCAAGGGAAAT
TGGCTACCCTGTCATGATCAAGGCCTCAGCA
GGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGAT
GAAGAGACCAGGGATGGTTT
TAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTAC
TAATAGAAA
AATTTATTGATAATCCTCGTCATATAGAAATCCAGGTTCTAGGTGATAAACATGGGAATG
C
TTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGTGGAG
GAAGCACCAAGC
ATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCTGT
AGCTCTTGCCAGAGCAGTAAAAT
ATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGACT
CTAAGAAGAATTTTTATTTCTTGGAAATGAATAC
AAGACTCCAGGTTGAGCATCCTGTC
ACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGT
GTTGCTAAGGGCTA
CCCTCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTC
GGG
TTTATGCTGAGGACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGT
ACCAAGA
ACCGTTACATCTACCTGGTGTCCGAGTGGACAGTGGCATCCAACCAGGAAGT
GATATTAGCATTTATTAT
GATCCTATGATTTCAAAACTAATCACATATGGCTCTGATAG
AACTGAGGCACTGAAGAGAATGGCAGATG
CACTGGATAACTATGTTATTCGAGGTGTTA
CACATAATATTGCATTACTTCGAGAGGTGATAATCAACTC
ACGCTTTGTAAAAGGAGAC
ATCAGCACTAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAGGACAC
ATGCTAAC
CAAGAGTGAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTT
AA
GAGCACAACATTTTCAAGAAAATTCAAGAATGCCTGTTATTAAACCAGACATAGCCA
ACTGGGAGCTCTC
AGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAAT
GGGTCAGTGTTCTCGGTGGAAGTT
GATGGGTCGAAACTAAATGTGACCAGCACGTGGAA
CCTGGCTTCGCCCTTATTGTCTGTCAGCGTTGATG
GCACTCAGAGGACTGTCCAGTGTC
TTTCTCGAGAAGCAGGTGGAAACATGAGCATTCAGTTTCTTGGTAC
AGTGTACAAGGTG
AATATCTTAACCAGACTTGCCGCAGAATTGAACAAATTTATGCTGGAAAAAGTGACT
GA
GGACACAAGCAGTGTTCTGCGTTCCCCGATGCCCGGAGTGGTGGTGGCCGTCTCTGTCAA
GCCTGGAG
ACGCGGTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGC
AGAATAGTATGACAGCTGG
GAAAACTGGCACGGTGAAATCTGTGCACTGTCAAGCTGGA
GACACAGTTGGAGAAGGGGATCTGCTCGTG
GAGCTGGAATGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X14608

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:13

# Metabolic_Enzyme_8_Locus:
13q32

# Metabolic_Enzyme_8_SNPs:
rs16957356; rs538229; rs2390383; rs2039677; rs945884; rs1283280; rs2254579; rs1296332; rs681561; rs1556799; rs2760308; rs2893018; rs767282; rs1890139; rs767281; rs675342; rs2783228; rs837335; rs837332; rs2184970; rs1889681; rs2038672; rs2760306; rs1556801; rs2043347; rs1034266; rs3783169; rs7989467; rs9518035; rs2281709; rs7335573; rs1283289; rs2893025; rs9300589; rs7983901; rs4772284; rs6491551; rs733275; rs2152881; rs4489854; rs2277437; rs9518016; rs9300602; rs7333958; rs6491547; rs7997808; rs7990105; rs4772302; rs3902595; rs7492217; rs9518017; rs6491555; rs6491561; rs7991183; rs2253546; rs4499105; rs9585372; rs9585448; rs7983459; rs4772293; rs2783226; rs11069395; rs6491564; rs1000160; rs11839967; rs1297355; rs1112044; rs837325; rs8002078; rs7998989; rs9300597; rs4772278; rs4772300; rs2783230; rs2390465; rs7997125; rs9518060; rs7322595; rs2783212; rs837324; rs3783172; rs4772292; rs2277436; rs9585348; rs7981326; rs12583282; rs7984538; rs7998080; rs4306370; rs6491544; rs7333362; rs7996215; rs4772291; rs6491563; rs11069396; rs4772268; rs6491567; rs7990780; rs2783224; rs9300598; rs9518081; rs7318781; rs9557426; rs9513740; rs4772270; rs2390399; rs837322; rs9557399; rs684215; rs2390402; rs9513735; rs9585387; rs7339265; rs10851114; rs9554686; rs9518053; rs837290; rs2057447; rs2484360; rs9743146; rs2150883; rs1298169; rs9554681; rs7984311; rs2146653; rs2184382; rs9557432; rs3783171; rs7982776; rs6491566; rs9585385; rs1283292; rs9518011; rs7326758; rs1888839; rs7328935; rs2390401; rs9513736; rs9557398; rs8001633; rs4772271; rs2783222; rs837323; rs4771357; rs6491562; rs6491554; rs4772265; rs1415685; rs9585449; rs7318874; rs1298507; rs8002928; rs2039679; rs9518077; rs11069401; rs12428848; rs7326712; rs9518047; rs3783174; rs9557397; rs1298919; rs7989679; rs1745799; rs3825505; rs1292969; rs7991251; rs12708381; rs1415684; rs837292; rs1556800; rs9300591; rs4771360; rs12431036; rs837318; rs6491560; rs9518049; rs7325804; rs12100240; rs9554684; rs6491565; rs9300586; rs837328; rs9585412; rs2390464; rs6491557; rs1972237; rs7981517; rs1998467; rs4772269; rs4772280; rs11620415; rs655862; rs2485550; rs9518012; rs2482463; rs681487; rs9585419; rs7993680; rs12586047; rs7324795; rs3783181; rs17493763; rs9518036; rs9557380; rs17196569; rs9513748; rs1283279; rs3783177; rs11617787; rs9585416; rs1577898; rs1407761; rs837329; rs9554670; rs3783173; rs7990089; rs11840109; rs7998326; rs7319383; rs6491558; rs837334; rs9518014; rs7339213; rs837286; rs1932240; rs4483714; rs7987087; rs9518032; rs9582395; rs6491556; rs9300600; rs12430531; rs9518013; rs2104868; rs1610386; rs9557430; rs2760311; rs837321; rs7991032; rs9554685; rs4772299; rs10492559; rs2783209; rs1889682; rs6491543; rs7324156; rs9582378; rs7998122; rs2057449; rs9582393; rs12430759; rs17196604; rs17491680; rs2476207; rs10508043; rs9513739; rs6491549; rs837289; rs9585415; rs13378764; rs9518029; rs4771355; rs3783176; rs10851115; rs837294; rs945882; rs958424; rs12019900; rs4772295; rs9557448; rs7339029; rs11618349; rs6491553; rs9585401; rs2760312; rs3759477; rs6491546; rs7998419; rs17196645; rs9300601; rs9518039; rs9585424; rs837285; rs2181482; rs2253446; rs9518033; rs4771358; rs12428645; rs2039678; rs3742245; rs1889683; rs12431159; rs12853977; rs6491559; rs9557383; rs7983948; rs9518015; rs9300605; rs11839348; rs2390469; rs7325252; rs7997468; rs9518041; rs9300599; rs1297356; rs17196583; rs2152880; rs2095487; rs6491548; rs2760310; rs16957441; rs9518048; rs7319215; rs7330241; rs9513757; rs1283287; rs16957276; rs9518074; rs9554677; rs9557413; rs9582387; rs4561310; rs2783223; rs4772294; rs12583054; rs9300595; rs6491545; rs837288; rs17474996; rs9518042; rs9557419; rs9557382; rs16957301; rs2184971; rs9518078; rs12429006; rs7984576; rs6650288; rs7338151; rs7335466; rs7334796; rs7318220; rs3858784; rs7338491; rs7317761; rs11842730; rs9557381; rs9582386; rs9554698; rs9585369; rs12867712; rs7998254; rs9557429; rs2390468; rs837284; rs9557446; rs9554692; rs12585450; rs9557407; rs3783180; rs7326745; rs9518019; rs7995301; rs11840872; rs9518050; rs11620125; rs12431335; rs7991498; rs7995634; rs7994935; rs837337; rs8000597; rs837287; rs2146652; rs611122; rs4772283; rs7983989; rs7983504; rs9554671; rs17569833; rs7984330; rs837342; rs7328351; rs1298921; rs7984396; rs7318347; rs9554688; rs12877004; rs4526878; rs8002362; rs3783170; rs16957309; rs16957278; rs3783183; rs9557384; rs7987388; rs9518055; rs9554668; rs7333194; rs9518061; rs499180; rs11843919; rs9585366; rs11069390; rs2783218; rs11842591; rs12428073; rs9518084; rs4772266; rs9585406; rs7330254; rs1932241; rs1283290; rs4772273; rs7998029; rs9557393; rs8001168; rs12428535; rs28537986; rs1745806; rs7998142; rs11843106; rs12860027; rs12431182; rs9582369; rs1283284; rs9585423; rs7333379; rs9585370; rs2065748; rs7335918; rs7997932; rs9585431; rs2787867; rs9554691; rs837297; rs17492220; rs9554675; rs9585361; rs9300604; rs9585442; rs7998207; rs9585452; rs9557396; rs11840082; rs4771356; rs9582379; rs1283281; rs7991210; rs4772296; rs1932239; rs9300603; rs857294; rs7989993; rs9582398; rs1124035; rs2783217; rs3215976; rs7320133; rs6491552; rs629509; rs16957348; rs9585427; rs4322518; rs11840165; rs12429061; rs17196562; rs9557436; rs3783184; rs1298506; rs2482464; rs12864917; rs837293; rs837319; rs2783229; rs8001073; rs7995595; rs7997368; rs1292970; rs9518028; rs530936; rs7993746; rs1115189; rs4771363; rs9518044; rs2184554; rs9554697; rs9518038; rs9554676; rs9582385; rs12867319; rs17254227; rs7326971; rs7991395; rs7328106; rs2057450; rs7324290; rs4772267; rs9585405; rs2255873; rs4772274; rs12428048; rs12431051; rs9513744; rs4772288; rs7982075; rs12853194; rs473180; rs9585383; rs837298; rs7986115; rs9513759; rs7329607; rs7324860; rs9554680; rs9557378; rs7999074; rs539158; rs9557443; rs3783178; rs2150886; rs1034267; rs7998648; rs9518040; rs4772286; rs12870630; rs7333679; rs1577899; rs1074602; rs9513731; rs9518064; rs7400074; rs7328528; rs7319103; rs9585417; rs1283357; rs2783216; rs569393; rs1283293; rs6650267; rs7326284; rs9557414; rs9557412; rs2783211; rs7999397; rs7996261; rs9585441; rs16957305; rs9585363; rs9585350; rs9585352; rs7326580; rs11840848; rs7994168; rs3949482; rs11069399; rs837326; rs9554689; rs16957340; rs4772264; rs1283285; rs17792266; rs12431042; rs1856217; rs9513743; rs12430705; rs7999102; rs4772279; rs17492046; rs9585450; rs2485548; rs9518004; rs837295; rs16957384; rs9557437; rs12560555; rs7981883; rs12018334; rs2095025; rs7337028; rs16957280; rs9518037; rs7996460; rs1300090; rs13378881; rs7997732; rs9585357; rs7331834; rs7328501; rs1624962; rs4622375; rs12429310; rs7318324; rs9585410; rs9585371; rs9557391; rs7329820; rs8001215; rs16957391; rs2390466; rs2152274; rs9582392; rs35055557; rs958439; rs7319707; rs4771362; rs12430993; rs9518063; rs4771365; rs9585368; rs9585377; rs9554699; rs11839111; rs7984104; rs1283288; rs11839052; rs4772298; rs4772285; rs7336442; rs16957255; rs7319434; rs7991180; rs4772276; rs4772290; rs7993067; rs2057448; rs11842030; rs7339196; rs9518054; rs10775030; rs9557386; rs9585432; rs9557389; rs4771361; rs9300590; rs9518006; rs4625587; rs4424775; rs7330289; rs9585364; rs7336947; rs837336; rs9518080; rs12874460; rs9300606; rs9585440; rs1745800; rs9582388; rs9585381; rs7139771; rs11840916; rs837291; rs9585386; rs1745807; rs7337835; rs9585407; rs1283282; rs1298922; rs7997975; rs9513742; rs4772281; rs1283286; rs9585411; rs9585408; rs12428913; rs2150882; rs837296; rs9557385; rs8002537; rs4771364; rs837317; rs7329721; rs17612953; rs2057446; rs9554669; rs9557445; rs9518059; rs9518062; rs4772272; rs837333; rs8000615; rs9557421; rs9513745; rs3783175; rs2783227; rs11069400; rs7321438; rs9518023; rs7993241; rs3742251; rs3742250; rs35719359; rs11539554; rs41281120; rs3899076; rs15466; rs41281122; rs41281124; rs35218503; rs1577900; rs35706510; rs9582371; rs28526486; rs12021107; rs35803542; rs9585437; rs9585443; rs5806157; rs7993228; rs34466523; rs35122716; rs10661172; rs9557433; rs2390435; rs11355553; rs34328488; rs12869110; rs28661086; rs9557410; rs9585397; rs11459500; rs11616574; rs9557424; rs35156913; rs5003101; rs1953696; rs35796452; rs10524763; rs7320936; rs35093653; rs12864519; rs9513756; rs12862978; rs9554679; rs9585360; rs10604327; rs35369764; rs35125499; rs9585446; rs34738581; rs9518075; rs837320; rs9554678; rs34906541; rs9554700; rs28688090; rs35416560; rs34061785; rs7334376; rs11620549; rs9513760; rs9518005; rs35596876; rs10689053; rs9585392; rs28791556; rs7489822; rs28718206; rs33937642; rs35291158; rs5806153; rs9513752; rs3058405; rs9585403; rs34460515; rs10678691; rs2184553; rs12863689; rs9518030; rs9585359; rs35584409; rs11362141; rs11349569; rs10547695; rs11289175; rs11330623; rs35332994; rs12017175; rs9585422; rs3842309; rs28841347; rs9518066; rs11332898; rs34453394; rs34801958; rs10638400; rs9585384; rs16957232; rs12877483; rs12877100; rs9585345; rs9585413; rs12866574; rs28687769; rs11360946; rs34224240; rs12020635; rs4356338; rs11324666; rs9557416; rs9585365; rs9582394; rs4142254; rs11620277; rs9513737; rs9557402; rs12870346; rs34690408; rs35753173; rs35302187; rs1299717; rs7322773; rs35260191; rs2390430; rs3034652; rs10528668; rs9585380; rs35322811; rs34997795; rs12866977; rs7335300; rs35100060; rs9585391; rs9582381; rs9518070; rs12865697; rs10467267; rs35971629; rs1575426; rs9513750; rs11427645; rs34719542; rs9582376; rs35891374; rs35316615; rs3930954; rs5806158; rs2095687; rs9634520; rs35377395; rs12872748; rs10710806; rs9518001; rs35434538; rs4772289; rs11298759; rs12868924; rs9585409; rs9518079; rs7326540; rs33945207; rs35503587; rs34304223; rs9585426; rs35322720; rs28687796; rs35779718; rs4301891; rs9585428; rs35199463; rs34015838; rs34236601; rs11838790; rs35495647; rs7324843; rs476423; rs9513730; rs9585378; rs9585389; rs9518043; rs10523177; rs12867888; rs35668106; rs28513438; rs36067066; rs34450564; rs3759478; rs35025633; rs9582373; rs35916377; rs11469076; rs34884605; rs34750393; rs12583455; rs34318074; rs9557442; rs34853750; rs10659778; rs950464; rs35895984; rs7322344; rs1283283; rs9585347; rs2760309; rs3034687; rs9557447; rs9518051; rs35433903; rs35795158; rs13378999; rs35362032; rs11269288; rs11295976; rs12877028; rs9513755; rs9518056; rs12585094; rs9585356; rs9557406; rs35058674; rs1407762; rs9518076; rs35145273; rs9557450; rs3034643; rs35054945; rs13378781; rs12100366; rs34277733; rs35338370; rs34532636; rs35233154; rs28479616; rs12864511; rs4772275; rs35523660; rs5806149; rs9585362; rs34978050; rs10129081; rs35763665; rs9557411; rs12864647; rs7991968; rs837330; rs11370189; rs9582370; rs35258256; rs34833232; rs36061462; rs9585414; rs35589266; rs34337277; rs35284370; rs7991510; rs7316948; rs35792322; rs4594108; rs34902611; rs34860703; rs2255870; rs35693167; rs34598548; rs35822001; rs35097485; rs9513734; rs34500107; rs7982816; rs12855571; rs34459939; rs36103425; rs9557405; rs12876330; rs34819598; rs34101703; rs5806150; rs5806160; rs10635557; rs35815231; rs12560943; rs7327479; rs2011329; rs16957249; rs11308030; rs36103827; rs12864651; rs7989113; rs10543745; rs28627700; rs36094195; rs34584543; rs9518083; rs34493131; rs2390431; rs3837564; rs16957258; rs4772301; rs36018621; rs9585390; rs17675144; rs35207720; rs9518071; rs35189840; rs7320549; rs35006674; rs11285694; rs12100195; rs11069391; rs28408802; rs34279630; rs34678286; rs9557417; rs34915815; rs11427230; rs34994367; rs9585373; rs2485547; rs9554694; rs11429370; rs2068451; rs34768722; rs36102222; rs12867207; rs28538960; rs36097264; rs12431041; rs16957362; rs2760316; rs9557400; rs35771657; rs11434240; rs4433673; rs3840814; rs12560571; rs16957245; rs12870926; rs36122017; rs2150884; rs9585451; rs7336260; rs12865897; rs7327523; rs34774210; rs11301747; rs35109451; rs12017512; rs34711695; rs9585399; rs34008829; rs11445363; rs10707237; rs9585388; rs7335221; rs36043786; rs9582372; rs34275910; rs9585379; rs35709393; rs12865702; rs9518065; rs670267; rs10628487; rs5806159; rs5806163; rs4261386; rs36007149; rs10467266; rs35705573; rs35809308; rs12874223; rs34917017; rs36006722; rs9300593; rs36065725; rs34765739; rs4772287; rs34256704; rs34724712; rs3742246; rs34499580; rs12869896; rs9518052; rs9557409; rs35341211; rs11840220; rs11290977; rs12864307; rs34887615; rs9585429; rs35356122; rs34276767; rs837331; rs34877951; rs35353266; rs11418617; rs7318831; rs35418436; rs9513754; rs35324283; rs35903696; rs10532627; rs11341639; rs35323808; rs13313342; rs865665; rs33975886; rs9300587; rs7338869; rs7325806; rs12864297; rs35559113; rs837340; rs10664308; rs3059677; rs9585420; rs35907275; rs9585382; rs12864837; rs10668689; rs7336935; rs9518008; rs12873170; rs1407763; rs3058594; rs36073901; rs35971474; rs10601032; rs6145198; rs9557404; rs9585394; rs34909389; rs36098330; rs34204823; rs11415038; rs34092855; rs837338; rs35401040; rs4001007; rs3825507; rs9557392; rs34528219; rs9557395; rs10606930; rs36102435; rs1974268; rs34516203; rs28607660; rs5806148; rs9582380; rs34622804; rs9582389; rs10591009; rs9518045; rs28650871; rs8181885; rs34407991; rs34944334; rs12869250; rs35077778; rs9557441; rs36055642; rs35750831; rs9557401; rs12864303; rs3088068; rs2390433; rs35996077; rs9513747; rs35686595; rs36112331; rs2390432; rs9518072; rs9518057; rs34301097; rs9557440; rs9585433; rs9518069; rs9585439; rs9554695; rs35132430; rs9585374; rs1576749; rs4772282; rs34026332; rs9554666; rs12100122; rs35584361; rs2484361; rs11439835; rs35091131; rs10688336; rs9554690; rs35539537; rs9557427; rs34433157; rs35959916; rs35612172; rs10540542; rs7990651; rs13378894; rs34214400; rs9554696; rs16957263; rs1890317; rs11459166; rs35462522; rs28735769; rs11308074; rs5806162; rs4592517; rs34812833; rs35303505; rs5806155; rs12875272; rs3837563; rs9557431; rs35563553; rs9554673; rs9582375; rs9518087; rs34268384; rs10540137; rs34731560; rs9300594; rs9557444; rs2208991; rs9585421; rs34061633; rs9557420; rs2105131; rs9557438; rs34456372; rs10613480; rs12865092; rs10628557; rs35565115; rs8181802; rs9557422; rs34079344; rs35217402; rs16957227; rs12875886; rs35822727; rs34078284; rs585662; rs36028025; rs36087144; rs7326430; rs35058442; rs34062773; rs9557379; rs10681816; rs7330143; rs35362938; rs12855843; rs2275308; rs11069392; rs34688976; rs9518058; rs12864683; rs9585398; rs7338308; rs11460805; rs9557418; rs34111533; rs28609665; rs11415881; rs28498276; rs34099057; rs34382982; rs28565916; rs10714550; rs3034651; rs10559269; rs3742248; rs34099689; rs33939903; rs35195082; rs34411352; rs7490699; rs837341; rs34041195; rs35480161; rs9585445; rs2485549; rs34291904; rs837327; rs9518067; rs837339; rs6491550; rs9585418; rs35712396; rs1885857; rs35502067; rs12866571; rs34448856; rs3058409; rs521273; rs34304013; rs28689742; rs35328550; rs9585351; rs9585349; rs4630394; rs35363090; rs10535490; rs2150885; rs10657744; rs7997277; rs34601214; rs11357539; rs9518085; rs35040953; rs2390434; rs9585404; rs28712549; rs35970742; rs35359284; rs35700826; rs9300588; rs9554693; rs9585425; rs9557428; rs7324491; rs12867611; rs11439153; rs10579468; rs3034654; rs12856604; rs12854911; rs34245334; rs11397353; rs12561151; rs9582396; rs9518073; rs8181884; rs9582400; rs28678447; rs9582377; rs9585358; rs9518068; rs35524627; rs9634521; rs35541111; rs11329867; rs9557449; rs34756197; rs9557435; rs9585438; rs28584582; rs13378193; rs9557394; rs12430630; rs35499079; rs9518046; rs7324595; rs34512005; rs7992830; rs35997465; rs4771354; rs36013684; rs11459852; rs35796024; rs3840000; rs35836219; rs5806161; rs9557434; rs36018558; rs34528026; rs10709727; rs9513733; rs2181483; rs34886548; rs35481117; rs35861672; rs9585393; rs7337677; rs34610298; rs9554674; rs35505501; rs28396410; rs34752772; rs35930661; rs5806151; rs12561161; rs34909719; rs4083752; rs11326412; rs2105130; rs28488250; rs9585400; rs34567478; rs35640811; rs28750247; rs9554687; rs7336287; rs12869263; rs9557390; rs9557403; rs28647513; rs8181887; rs34223246; rs34394682; rs1283291; rs12875978; rs8001596; rs7984018; rs10545091; rs9585354; rs12861615; rs11319347; rs7998878; rs11838791; rs34185685; rs2482462; rs11377141; rs12871481; rs35429295; rs8002297; rs12872169; rs35816963; rs2390467; rs3034650; rs34300502; rs11462726; rs35931512; rs9518018; rs35445114; rs28705975; rs10685524; rs9518086; rs34336952; rs11450784; rs34279341; rs41281118; rs11333141; rs10523739; rs34997541; rs11350199; rs11439395; rs7324988; rs12016978; rs9557439; rs3034690; rs5806156; rs11315386; rs9585444; rs35520065; rs34884178; rs9518002; rs10454528; rs35027327; rs9557423; rs34109551; rs34133206; rs35437792; rs34689498; rs36065592; rs3742252; rs12873320; rs12873358; rs3742249; rs9513729; rs35321520; rs12100185; rs16957483; rs1885858; rs2760307; rs28706364; rs35235268; rs35998503; rs4772303; rs7140059; rs7335993; rs7984886; rs837301; rs837343; rs837344; rs9513721; rs9585454

# Metabolic_Enzyme_8_General_References:
2740237; 3460076; 8434582; 3555348; 10502773; 10101253; 12559849; 10329019

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5248

# Metabolic_Enzyme_9_Name:
Pyruvate carboxylase, mitochondrial precursor

# Metabolic_Enzyme_9_Synonyms:
Pyruvic carboxylase; PCB

# Metabolic_Enzyme_9_Gene_Name:
PC

# Metabolic_Enzyme_9_Protein_Sequence:
>Pyruvate carboxylase, mitochondrial precursor
MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELG
IRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGF
LSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEA
HEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIE
KPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAK
QVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL
GLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP
HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQF
IDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAG
FRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSK
LFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVF
KFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSL
QYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGV
AAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEG
ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQM
LGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFP
EPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHF
KDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFEL
NGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVL
SAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE

# Metabolic_Enzyme_9_Number_of_Residues:
1178

# Metabolic_Enzyme_9_Molecular_Weight:
129635

# Metabolic_Enzyme_9_Theoretical_pI:
6.83

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  ligase activity, forming carbon-carbon bonds
Function:  pyruvate carboxylase activity
Function:  ligase activity
Function:  vitamin binding
Function:  biotin binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  gluconeogenesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate

# Metabolic_Enzyme_9_Pathway:
map00020  Citrate cycle (TCA cycle);
 map00252  Alanine and aspartate metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF02785:Biotin_carb_C;
PF00364:Biotin_lipoyl;
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2;
PF00682:HMGL-like;
PF02436:PYC_OADA

# Metabolic_Enzyme_9_Signals:
1-21

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 6.4.1.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
458236

# Metabolic_Enzyme_9_SwissProt_ID:
PYC_HUMAN (P11498)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PC

# Metabolic_Enzyme_9_Geneatlas_id:
PC

# Metabolic_Enzyme_9_hgnc_id:
HGNC:8636

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_9_Gene_Sequence:
>3537 bp
ATGCTGAAGTTCCGAACAGTCCATGGGGGCCTGAGGCTCCTGGGAATCCGCCGAACCTCC
ACCGCCCCCGCTGCCTCCCCAAATGTCCGGCGCCTGGAGTATAAGCCCATCAAGAAAGTC
ATGGTGGCCAACAGAGGTGAGATTGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGC
ATCCGCACCGTAGCCATCTACTCTGAGCAGGACACGGGCCAGATGCACCGGCAGAAAGCA
GATGAAGCCTATCTCATCGGCCGCGGCCTGGCCCCCGTGCAGGCCTACCTGCACATCCCA
GACATCATCAAGGTGGCCAAGGAGAACAACGTAGATGCAGTGCACCCTGGCTACGGGTTC
CTCTCTGAGCGAGCGGACTTCGCCCAGGCCTGCCAGGATGCAGGGGTCCGGTTTATTGGG
CCAAGCCCAGAAGTGGTCCGCAAGATGGGAGACAAGGTGGAGGCCCGGGCCATCGCCATT
GCTGCGGGTGTTCCCGTTGTCCCTGGCACAGATGCCCCCATCACGTCCCTGCATGAGGCC
CACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCGGCCTATGGGGGTGGA
GGGCGTGGCATGAGGGTGGTGCACAGCTACGAGGAGCTGGAGGAGAATTACACCCGGGCC
TACTCAGAGGCTCTGGCCGCCTTTGGGAATGGGGCGCTGTTTGTGGAGAAGTTCATCGAG
AAGCCACGGCACATCGAGGTGCAGATCTTGGGGGACCAGTATGGGAACATCCTGCACCTG
TACGAGCGAGACTGCTCCATCCAGCGGCGGCACCAGAAGGTGGTCGAGATTGCCCCCGCC
GCCCACCTGGACCCGCAGCTTCGGACTCGGCTCACCAGCGACTCTGTGAAACTCGCTAAA
CAGGTGGGCTACGAGAACGCAGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCAC
TACTTCATCGAGGTCAACTCCCGCCTGCAGGTGGAGCACACGGTCACAGAGGAGATCACC
GACGTAGACCTGGTCCATGCTCAGATCCACGTGGCTGAGGGCAGGAGCCTACCCGACCTG
GGCCTGCGGCAGGAGAACATCCGCATCAACGGGTGTGCCATCCAGTGCCGGGTCACCACC
GAGGACCCCGCGCGCAGCTTCCAGCCGGACACCGGCCGCATTGAGGTGTTCCGGAGCGGA
GAGGGCATGGGCATCCGCCTGGATAATGCTTCCGCCTTCCAAGGAGCCGTCATCTCGCCC
CACTACGACTCCCTGCTGGTCAAAGTCATTGCCCACGGCAAAGACCACCCCACGGCCGCC
ACCAAGATGAGCAGGGCCCTTGCGGAGTTCCGCGTCCGAGGTGTGAAGACCAACATCGCC
TTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTC
ATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTG
TTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCC
AGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGT
TTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCAC
CCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACT
CGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAG
CTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTAT
GAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAG
ATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTC
AAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTC
AACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTG
GAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTG
CAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATC
AAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGG
GACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTG
GCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCC
ATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACT
CCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGG
GCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGAC
GTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGC
ATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATG
CTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTT
ATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTT
CCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCC
GAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCC
TCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAG
GAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTC
AAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAG
GGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATC
AAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTC
AATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTC
CACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTG
ATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTC
AGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTT
CATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
U04641

# Metabolic_Enzyme_9_Chromosome_Location:
Not Available

# Metabolic_Enzyme_9_Locus:
Not Available

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
7918683; 8048912; 3555348; 6548474; 9585612; 9585002

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
7434

# Metabolic_Enzyme_10_Name:
Caspase-3 precursor

# Metabolic_Enzyme_10_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Metabolic_Enzyme_10_Gene_Name:
CASP3

# Metabolic_Enzyme_10_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Metabolic_Enzyme_10_Number_of_Residues:
277

# Metabolic_Enzyme_10_Molecular_Weight:
31608

# Metabolic_Enzyme_10_Theoretical_pI:
6.51

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Not Available

# Metabolic_Enzyme_10_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Metabolic_Enzyme_10_Pathway:
Not Available

# Metabolic_Enzyme_10_Reaction:
Not Available

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.4.22.56

# Metabolic_Enzyme_10_GenBank_ID_Protein:
561666

# Metabolic_Enzyme_10_SwissProt_ID:
CASP3_HUMAN (P42574)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
CASP3

# Metabolic_Enzyme_10_Geneatlas_id:
CASP3

# Metabolic_Enzyme_10_hgnc_id:
HGNC:1504

# Metabolic_Enzyme_10_PDB_ID:
1CP3

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U13737

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q34

# Metabolic_Enzyme_10_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Metabolic_Enzyme_10_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Metabolic_Enzyme_10_References:
15956583; 15971673; 16254845; 16374167

# Metabolic_Enzyme_11_ID:
7792

# Metabolic_Enzyme_11_Name:
Mitogen-activated protein kinase 14

# Metabolic_Enzyme_11_Synonyms:
Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A

# Metabolic_Enzyme_11_Gene_Name:
MAPK14

# Metabolic_Enzyme_11_Protein_Sequence:
>Mitogenactivated protein kinase 14
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES


# Metabolic_Enzyme_11_Number_of_Residues:
360

# Metabolic_Enzyme_11_Molecular_Weight:
41294

# Metabolic_Enzyme_11_Theoretical_pI:
5.58

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis

# Metabolic_Enzyme_11_Pathway:
Not Available

# Metabolic_Enzyme_11_Reaction:
Not Available

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_11_GenBank_ID_Protein:
603917

# Metabolic_Enzyme_11_SwissProt_ID:
MK14_HUMAN (Q16539)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
MAPK14

# Metabolic_Enzyme_11_Geneatlas_id:
MAPK14

# Metabolic_Enzyme_11_hgnc_id:
HGNC:6876

# Metabolic_Enzyme_11_PDB_ID:
1W84

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_11_Gene_Sequence:
>1083 bp
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
L35263

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_11_Locus:
6p21.3-p21.2

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
7997261; 7696354; 7479834; 10727080; 11866441; 14574404; 12665801; 7923354; 7493921; 10943842; 10838079; 8910361; 9095200; 9753691

# Metabolic_Enzyme_11_References:
15979553

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
16410837; 16602722; 17023148

# Macromolecular_Interacting_Partner_2_ID:
5331

# Macromolecular_Interacting_Partner_2_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_2_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_2_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_2_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_2_Signals:
1-19

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_2_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q37

# Macromolecular_Interacting_Partner_2_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_2_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_2_References:
15907640; 16459608; 16890168; 17107008

# Macromolecular_Interacting_Partner_3_ID:
6352

# Macromolecular_Interacting_Partner_3_Name:
Atrial natriuretic peptide receptor B precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
ANP-B; ANPRB; GC-B; Guanylate cyclase B; NPR-B; Atrial natriuretic peptide B-type receptor

# Macromolecular_Interacting_Partner_3_Gene_Name:
NPR2

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Atrial natriuretic peptide receptor B precursor
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
GDVEMKGKGKMRTYWLLGERKGPPGLL

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
1047

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
117024

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.86

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP > BNP > ANP

# Macromolecular_Interacting_Partner_3_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_3_Reaction:
GTP = 3',5'-cyclic GMP + diphosphate

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01094:ANF_receptor;
PF00211:Guanylate_cyc;
PF00069:Pkinase

# Macromolecular_Interacting_Partner_3_Signals:
1-22

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
459-478

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
EC 4.6.1.2

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
5139790

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
ANPRB_HUMAN (P20594)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
NPR2

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
NPR2

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:7944

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>3144 bp
ATGGCGCTGCCATCACTTCTGCTGTTGGTGGCAGCCCTGGCAGGTGGGGTGCGTCCTCCC
GGGGCGCGGAACCTGACGCTGGCGGTGGTGCTGCCAGAACACAACCTGAGCTATGCCTGG
GCCTGGCCACGGGTGGGACCCGCTGTGGCACTAGCTGTGGAGGCTCTGGGCCGGGCACTG
CCCGTGGACCTGCGGTTTGTCAGCTCCGAACTGGAAGGCGCCTGCTCTGAGTACCTGGCA
CCGCTGAGCGCTGTGGACCTCAAGCTGTACCATGACCCCGACCTGCTGTTAGGTCCCGGT
TGCGTGTACCCTGCTGCCTCTGTGGCCCGCTTTGCCTCCCACTGGCGCCTTCCCCTGCTG
ACTGCGGGTGCTGTGGCCTCTGGTTTTTCGGCTAAGAATGACCATTATCGTACCCTGGTT
CGCACTGGCCCCTCTGCTCCCAAGCTGGGTGAGTTTGTGGTGACACTACACGGGCACTTC
AATTGGACTGCCCGTGCTGCCTTGCTGTACCTGGATGCTCGCACAGATGACCGGCCTCAC
TACTTCACCATCGAGGGCGTCTTTGAGGCCCTGCAGGGCAGCAACCTCAGTGTGCAGCAC
CAGGTGTATGCCCGAGAGCCAGGGGGCCCCGAGCAGGCCACCCACTTCATCCGGGCCAAC
GGGCGCATTGTGTATATCTGCGGCCCTCTGGAGATGCTGCATGAGATCCTGCTTCAGGCC
CAGAGGGAGAATCTGACCAATGGGGATTATGTCTTCTTTTACCTGGATGTCTTTGGGGAG
AGTCTCCGTGCAGGCCCCACACGTGCTACAGGCCGGCCCTGGCAGGACAATCGCACCCGG
GAACAGGCCCAGGCCCTCAGAGAGGCCTTTCAGACTGTATTGGTGATCACGTACCGAGAA
CCCCCAAATCCTGAGTATCAGGAATTCCAGAATCGTCTGCTGATAAGAGCCCGGGAAGAC
TTTGGTGTGGAGCTGGGCCCTTCCCTGATGAACCTCATCGCTGGCTGCTTCTATGATGGG
ATCCTGCTATATGCTGAAGTCCTGAATGAGACAATACAGGAAGGAGGCACCCGGGAGGAT
GGACTTCGAATTGTGGAAAAGATGCAGGGACGAAGATATCACGGTGTAACTGGGCTGGTT
GTCATGGACAAGAACAATGACCGAGAGACTGACTTTGTCCTCTGGGCCATGGGAGACCTG
GATTCTGGGGACTTTCAGCCTGCAGCCCACTACTCGGGAGCTGAGAAGCAGATTTGGTGG
ACGGGACGGCCTATTCCCTGGGTGAAGGGGGCTCCTCCCTCGGACAATCCCCCCTGTGCC
TTTGACTTGGACGACCCATCCTGTGATAAAACTCCACTTTCAACCCTGGCAATTGTGGCT
CTGGGCACAGGAATCACCTTCATCATGTTTGGTGTTTCCAGCTTCCTAATTTTCCGAAAG
CTGATGCTGGAGAAGGAGCTGGCTAGCATGTTGTGGCGTATTCGCTGGGAAGAACTGCAG
TTTGGCAACTCAGAGCGTTATCACAAAGGTGCAGGCAGTCGCCTCACACTGTCGCTGCGG
GGATCCAGTTACGGCTCGCTCATGACAGCCCATGGGAAATACCAGATCTTTGCCAACACC
GGTCACTTCAAGGGAAATGTTGTCGCCATCAAACATGTGAATAAGAAGCGCATTGAGCTG
ACCCGGCAGGTTCTGTTTGAACTCAAACATATGAGAGATGTTCAGTTCAACCATCTCACT
CGCTTCATTGGCGCCTGCATAGACCCTCCCAACATTTGCATTGTCACTGAATACTGTCCT
CGTGGGAGTTTACAGGATATTCTAGAAAATGACAGCATCAACTTGGACTGGATGTTTCGT
TATTCACTCATTAATGACCTTGTTAAGGGCATGGCCTTTCTCCACAACAGCATTATTTCA
TCGCATGGGAGTCTCAAGTCCTCCAACTGTGTGGTGGATAGTCGTTTTGTGCTCAAAATC
ACAGACTATGGCCTGGCCAGCTTCCGATCAACTGCTGAACCTGATGACAGCCATGCCCTC
TATGCCAAGAAGCTGTGGACTGCCCCAGAACTGCTCAGTGGGAACCCCTTGCCAACCACA
GGCATGCAGAAGGCTGACGTCTATAGCTTTGGGATCATCCTGCAGGAGATAGCACTTCGC
AGTGGTCCTTTCTACTTGGAGGGCCTGGACCTCAGCCCCAAAGAGATTGTCCAGAAGGTA
CGAAATGGTCAGCGGCCATATTTCCGGCCAAGCATTGACCGGTCCCAACTGAATGAAGAG
CTAGTTTTGCTGATGGAGCGATGTTGGGCTCAGGACCCAGCTGAGCGGCCAGACTTTGGA
CAGATTAAGGGCTTCATTCGGCGCTTTAACAAGGAGGGTGGCACCAGCATATTGGACAAC
CTCCTGCTGCGCATGGAACAGTATGCCAATAACTTGGAGAAGCTGGTGGAGGAACGCACA
CAGGCCTATCTGGAGGAAAAACGCAAGGCTGAAGCTCTGCTCTACCAAATCCTACCCCAT
TCAGTGGCAGAGCAGTTAAAACGGGGAGAGACTGTACAGGCTGAGGCCTTTGACAGTGTT
ACCATCTACTTCAGTGACATTGTTGGCTTCACAGCATTGTCAGCAGAGAGCACCCCCATG
CAGGTAGTGACACTTCTTAATGACCTGTATACCTGCTTTGATGCCATAATTGACAACTTT
GATGTCTACAAGGTGGAGACGATTGGGGATGCTTACATGGTGGTATCTGGCCTCCCAGGC
CGAAATGGTCAACGCCATGCACCAGAAATTGCTCGTATGGCCCTAGCATTACTAGATGCA
GTTTCTTCCTTTCGCATCCGCCACCGACCCCATGACCAGCTGAGGCTACGCATAGGGGTC
CATACTGGGCCAGTCTGTGCTGGGGTTGTTGGCCTGAAGATGCCCCGTTATTGTCTTTTT
GGAGACACAGTGAACACTGCTTCTCGAATGGAGTCTAATGGTCAAGCGCTGAAGATCCAT
GTCTCCTCTACCACCAAGGATGCCCTAGATGAGCTAGGATGCTTCCAGCTAGAGCTTCGG
GGGGATGTGGAAATGAAGGGAAAAGGAAAGATGCGAACATACTGGCTCTTAGGAGAGCGG
AAAGGACCTCCTGGACTCCTGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AB005647

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_3_Locus:
9p21-p12

# Macromolecular_Interacting_Partner_3_SNPs:
rs2228580; rs5812; rs7043647; rs10758325; rs10814276; rs1322044; rs7034957; rs3793543; rs7021716; rs7031237; rs7864199; rs1407295; rs2236290; rs2236289; rs2890702; rs13288085; rs1078081; rs10758324; rs12347878; rs12553111; rs5816; rs28931581; rs28929479; rs3729731; rs3729730; rs28931582; rs5813; rs28764009; rs5815; rs4512468; rs5024028; rs13293624; rs28764011; rs34474231; rs28764014; rs4879927; rs10603903; rs35323702; rs12005446; rs35457827; rs12686421; rs34532812; rs28764012; rs3069788; rs11328092; rs35713408; rs35484064; rs1407296; rs28764008; rs1322043; rs35170845; rs28764010; rs35145770; rs28764013; rs34349173; rs3750438; rs3842217; rs34754193; rs10972585; rs35743544; rs10758323; rs10972591; rs12337802; rs12338156; rs12342037; rs13292880; rs13294264; rs13294295; rs13299765; rs2145923; rs2281645; rs2281646; rs3763631; rs3808864; rs3808865; rs4879928; rs4879929; rs6476491; rs7848310; rs7866903; rs7873145; rs878749; rs878750

# Macromolecular_Interacting_Partner_3_General_References:
2570358; 10082481; 10073597

# Macromolecular_Interacting_Partner_3_References:
15905112; 15992685; 16309850

# Macromolecular_Interacting_Partner_4_ID:
7936

# Macromolecular_Interacting_Partner_4_Name:
Apoptosis regulator Bcl-2

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
BCL2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Apoptosis regulator Bcl2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
239

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
26266

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.32

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of programmed cell death
Process:  regulation of apoptosis
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00452:Bcl-2;
PF02180:BH4

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
212-233

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
179367

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
BCL2_HUMAN (P10415)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
BCL2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
BCL2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:990

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass membrane protein. Nucleus; nuclear membrane; single- pass membrane protein. Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>720 bp
ATGGCGCACGCTGGGAGAACGGGGTACGACAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGCGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGGCCCTCCGCCAAGCC
GGCGACGACTTCTCCCGCCGCTACCGCGGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGAGCCACAAGTGA


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M13994

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_4_Locus:
18q21.33|18q21.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs1800477; rs1801018; rs1564483; rs1016860; rs4987853; rs4987861; rs4987843; rs4987852; rs3744935; rs4987864; rs4987856; rs4987854; rs4987855; rs4987846; rs4987851; rs4987858; rs4987850; rs4987859; rs4987865; rs4987845; rs4987869; rs3744937; rs4987847; rs1473418; rs4987867; rs720321; rs1383596; rs1944419; rs1531697; rs2046136; rs1545812; rs1481031; rs2332673; rs726510; rs899968; rs2062011; rs2850763; rs1381548; rs949037; rs2156192; rs2850761; rs7226979; rs1009726; rs4940576; rs2850762; rs6567334; rs2551397; rs2849377; rs2199937; rs4987792; rs11872403; rs11152377; rs4941195; rs4941183; rs2156190; rs2062010; rs8094489; rs11152375; rs12606418; rs8083946; rs726511; rs3810027; rs1542578; rs8094651; rs1462129; rs4941189; rs4941192; rs3810031; rs3943258; rs8088662; rs8096380; rs4940573; rs7228914; rs11661511; rs7240326; rs2156193; rs8086404; rs6567336; rs2849381; rs8094315; rs11876772; rs4987790; rs11152370; rs4987752; rs4940575; rs4456611; rs1893506; rs2046135; rs12457700; rs8088100; rs7242402; rs11661497; rs4940572; rs1944420; rs9955190; rs1944422; rs12454650; rs1977971; rs8089331; rs2850758; rs2046137; rs1573493; rs8084922; rs8089538; rs4987802; rs6567328; rs8095050; rs2156191; rs2849380; rs1481032; rs11875184; rs1807999; rs9807663; rs4940574; rs7230053; rs1982674; rs12457170; rs4941188; rs1344229; rs7234941; rs6567327; rs11152374; rs11152372; rs9965844; rs6567326; rs7239838; rs9962222; rs9959874; rs4940571; rs2187162; rs4987819; rs2051423; rs3810028; rs899966; rs4987739; rs6567329; rs4941185; rs4987718; rs10503079; rs8098548; rs3744933; rs3744948; rs17070798; rs4987760; rs8098848; rs4987788; rs7243201; rs4941187; rs12968517; rs4987772; rs4987722; rs4987803; rs731014; rs3744951; rs1982673; rs4987736; rs17070904; rs6567330; rs11659758; rs2850760; rs9967405; rs8099575; rs17757981; rs9630855; rs4987786; rs12454712; rs12457893; rs4987724; rs8099140; rs12970840; rs4987778; rs4987831; rs4987829; rs1026825; rs12458289; rs9972995; rs10503077; rs6567325; rs4987823; rs4987765; rs4987726; rs4987757; rs11152371; rs12605881; rs4987746; rs11875971; rs4987827; rs12961976; rs4987795; rs4987797; rs899965; rs7244617; rs1531695; rs9962656; rs12457831; rs11872329; rs4987838; rs4941184; rs2051424; rs2615200; rs7242542; rs8094630; rs7236090; rs6567324; rs7231914; rs1893806; rs4987768; rs17070959; rs1005793; rs8085707; rs17070739; rs11875686; rs17679032; rs4987721; rs4987808; rs765102; rs8097624; rs3744950; rs4987801; rs1009725; rs6567335; rs17070848; rs17685559; rs956572; rs12961672; rs11663275; rs744569; rs4987764; rs12457190; rs4941186; rs17070861; rs4941194; rs4987835; rs2170294; rs4987755; rs6567331; rs4987841; rs4987737; rs9959983; rs768058; rs7243091; rs8095077; rs4987725; rs4987733; rs17756073; rs11877475; rs8093973; rs4987839; rs4987759; rs4987783; rs960804; rs4987743; rs4987779; rs10503078; rs17757541; rs899964; rs7230970; rs4987716; rs7232625; rs9951943; rs9958550; rs8092560; rs4941190; rs12457371; rs4987828; rs3826622; rs8096471; rs8083727; rs4987821; rs2849382; rs9962051; rs17756365; rs17070913; rs8087120; rs2170295; rs4987810; rs6567332; rs899967; rs4987774; rs1381546; rs10460157; rs11873429; rs4987826; rs4987798; rs1473435; rs7242904; rs4987809; rs7242501; rs4987800; rs7232512; rs12957119; rs10164240; rs4987742; rs3948977; rs4987719; rs12458944; rs4987796; rs7231901; rs17678177; rs8099218; rs2551399; rs4987770; rs4987825; rs17070714; rs4987781; rs12962644; rs4987812; rs12963263; rs4987834; rs4987747; rs4987767; rs17758695; rs9963148; rs17841945; rs4987744; rs9959769; rs12457361; rs9946649; rs4987794; rs11152373; rs11872297; rs17070779; rs4987728; rs12963776; rs12958785; rs17686373; rs1976005; rs12457841; rs8092884; rs7240319; rs9946637; rs9961642; rs17759096; rs11877911; rs4987773; rs1944421; rs2170296; rs11877925; rs9961796; rs7230177; rs4987715; rs4987732; rs17070777; rs11874082; rs9965829; rs4987761; rs17758456; rs17062654; rs4987789; rs4987771; rs17070827; rs17758816; rs7232082; rs11661184; rs12962650; rs3842401; rs8098586; rs17678294; rs17677569; rs17070818; rs954954; rs9957149; rs1541298; rs4987717; rs9962421; rs17070841; rs4987730; rs8097918; rs8089306; rs12967026; rs7236202; rs4987750; rs17685987; rs2840358; rs4987787; rs4987780; rs17841946; rs4987723; rs7237139; rs1481030; rs12454618; rs12968867; rs9966563; rs17070877; rs17070809; rs9958905; rs6567333; rs3810030; rs4987741; rs12964150; rs9972996; rs7245234; rs1381547; rs17756248; rs4987807; rs12604822; rs17070735; rs17756266; rs4987824; rs12456572; rs2850755; rs17070943; rs4987749; rs17070946; rs17759659; rs12605858; rs4987791; rs4987815; rs9962963; rs3927911; rs8091529; rs4987822; rs8085473; rs4987731; rs17758403; rs4987745; rs4987818; rs9965425; rs4987793; rs1541295; rs4987832; rs12455492; rs4987720; rs4987817; rs2849379; rs17070750; rs4987830; rs4987873; rs2448799; rs8087606; rs4987872; rs2279115; rs41301945; rs5825508; rs2078303; rs4987849; rs17070680; rs41306972; rs34741396; rs4987866; rs34360708; rs34883036; rs1050618; rs34811186; rs4987707; rs4987868; rs4987844; rs4987862; rs34223591; rs4987842; rs4987870; rs4987848; rs4987710; rs4987860; rs34143126; rs4987706; rs3744936; rs4987863; rs4987857; rs11351478; rs35558540; rs36046351; rs34986306; rs11384331; rs12327138; rs34592237; rs34479040; rs35443488; rs35735146; rs4987738; rs35954402; rs9953797; rs11286497; rs34714510; rs34470267; rs2127872; rs34356346; rs10597397; rs7230110; rs5825509; rs4987769; rs11346802; rs35765197; rs35992365; rs28744646; rs35421280; rs7242051; rs7230703; rs3216124; rs11878084; rs3833192; rs9320014; rs34032861; rs10536242; rs28613776; rs35702853; rs35957660; rs11877270; rs36089071; rs11411155; rs34999271; rs28603232; rs8099362; rs11424742; rs34128466; rs4987740; rs36230193; rs35775563; rs34585115; rs9944895; rs4987754; rs34926393; rs35844118; rs4987753; rs4987763; rs9949240; rs4987751; rs7242531; rs11421019; rs28669125; rs28550381; rs28502762; rs28662060; rs34092929; rs28702921; rs35942763; rs35275357; rs35195646; rs2332672; rs7232179; rs11381388; rs34385891; rs34140806; rs28460613; rs2187163; rs35366804; rs28699603; rs4384687; rs35180138; rs12958555; rs4987713; rs4987805; rs35063180; rs28564323; rs9959358; rs4987837; rs596876; rs4987799; rs4987814; rs34360704; rs34927632; rs36074022; rs7232529; rs4987840; rs4987813; rs34603960; rs34737549; rs34810572; rs4987782; rs12956558; rs34724235; rs35832816; rs11396022; rs4987734; rs35916533; rs11426842; rs34422779; rs35788320; rs7243686; rs34269955; rs34821656; rs34331087; rs4987735; rs2615199; rs7245040; rs28537871; rs34628711; rs34530559; rs34280008; rs9946231; rs34246997; rs35618914; rs7504762; rs11285614; rs9955851; rs4987784; rs12454033; rs35117243; rs4987833; rs35832711; rs11876939; rs4987711; rs2085958; rs4987776; rs4987816; rs11271834; rs9807796; rs34929825; rs2849378; rs34498028; rs8094130; rs34272291; rs8089583; rs5825512; rs35786465; rs11437030; rs3810029; rs10560567; rs34392530; rs11875445; rs36010160; rs33935449; rs1870863; rs11874495; rs28566629; rs35829205; rs10604257; rs12327294; rs4987758; rs11407054; rs34122166; rs35501583; rs12454460; rs34597011; rs34215080; rs11664592; rs11330056; rs11348997; rs4987762; rs11346034; rs641060; rs35852603; rs34970907; rs7238198; rs35043985; rs10640757; rs35621103; rs34019962; rs4987820; rs11333396; rs12326606; rs11269260; rs36107927; rs34843082; rs35457535; rs12969008; rs10564352; rs4987748; rs35869219; rs1273018; rs28417258; rs17070962; rs34520768; rs34167266; rs34372247; rs34877412; rs1138828; rs12962685; rs12955832; rs28588396; rs12958518; rs33983598; rs4411604; rs2849374; rs8089784; rs1679896; rs12956104; rs35051109; rs28552905; rs3744949; rs34724758; rs7230557; rs4987811; rs34616260; rs34660120; rs34455531; rs7231840; rs4987766; rs11343409; rs11377778; rs11282101; rs11663364; rs12327297; rs12957272; rs34096346; rs12954887; rs35880134; rs8097683; rs7245041; rs11152376; rs11307145; rs11389759; rs34302549; rs35608542; rs34601248; rs35378587; rs34971240; rs7239903; rs4987727; rs34857794; rs34026129; rs36077676; rs34008827; rs11289698; rs28552745; rs35997590; rs36078664; rs10688243; rs35024611; rs35764546; rs34513836; rs34355655; rs720849; rs10718817; rs36027128; rs8092584; rs4987756; rs35555671; rs7242090; rs35771638; rs1789627; rs1271892; rs7236823; rs4987785; rs4987714; rs1462128; rs35032484; rs12605689; rs7239542; rs4941193; rs10537349; rs12970504; rs10642228; rs35689542; rs11393921; rs12962313; rs4987836; rs36095867; rs35696527; rs34059678; rs35046846; rs34022610; rs5825511; rs35369252; rs34870728; rs34960660; rs7244494; rs36099507; rs35770276; rs35956166; rs12964435; rs28562101; rs34051656; rs11271898; rs4987804; rs4987729; rs7231259; rs35818172; rs34831717; rs28464692; rs4987777; rs34298527; rs7504665; rs35161404; rs5825510; rs35593106; rs35291046; rs7230565; rs34430054; rs8098774; rs34875078; rs34683668; rs28484798; rs1531696; rs34596364; rs11399943; rs4987712; rs28431965; rs765479; rs34457708; rs36088248; rs12958359; rs2516293; rs34174534; rs35525138; rs2551400; rs35834230; rs4987705; rs4987871; rs2448798; rs2472571; rs35953169; rs34619379; rs10460159; rs11660715; rs17070659; rs17676919; rs17676949; rs17749561; rs1944423; rs2051422; rs2448800; rs2448804; rs2448805; rs2448806; rs2472572; rs2472574; rs2472576; rs2472577; rs2472578; rs2472579; rs2472581; rs2551402; rs2551404; rs2551405; rs2850764; rs698708; rs7243985; rs8086644; rs8094041; rs8099294; rs9320013; rs9945794; rs9957746; rs9989529

# Macromolecular_Interacting_Partner_4_General_References:
3523487; 1508712; 2875799; 2834197; 3285301; 1339299; 2250705; 8183370; 9395403; 8668206; 11368354; 10567572; 11463391; 12901880

# Macromolecular_Interacting_Partner_4_References:
16196285; 16867874

# Macromolecular_Interacting_Partner_5_ID:
8202

# Macromolecular_Interacting_Partner_5_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_5_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_5_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_5_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_5_References:
16153151; 16563343; 16723704

# Macromolecular_Interacting_Partner_6_ID:
8120

# Macromolecular_Interacting_Partner_6_Name:
Sodium-dependent multivitamin transporter

# Macromolecular_Interacting_Partner_6_Synonyms:
Na(+-dependent multivitamin transporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC5A6

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodiumdependent multivitamin transporter
MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELL
MADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPV
FYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSV
LALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGR
ISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPF
QQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLF
SGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQM
GPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMG
FSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIV
VGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKP
RNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
635

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
68703

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.32

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Transports pantothenate, biotin and lipoate in the presence of sodium

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
24-44
68-88
101-121
143-163
176-196
199-219
256-276
297-317
336-356
396-416
428-448
456-476
528-548

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
5006439

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC5A6_HUMAN (Q9Y289)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC5A6

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC5A6

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11041

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1908 bp
ATGAGTGTAGGGGTGAGCACCTCAGCCCCTCTTTCCCCAACCTCGGGCACAAGCGTGGGC
ATGTCTACCTTCTCCATCATGGACTATGTGGTGTTCGTCCTGCTGCTGGTTCTCTCTCTT
GCCATTGGGCTCTACCATGCTTGTCGTGGCTGGGGCCGGCATACTGTTGGTGAGCTGCTG
ATGGCGGACCGCAAAATGGGCTGCCTTCCGGTGGCACTGTCCCTGCTGGCCACCTTCCAG
TCAGCCGTGGCCATCCTGGGTGTGCCGTCAGAGATCTACCGATTTGGGACCCAATATTGG
TTCCTGGGCTGCTGCTACTTTCTGGGGCTGCTGATACCTGCACACATCTTCATCCCCGTT
TTCTACCGCCTGCATCTCACCAGTGCCTATGAGTACCTGGAGCTTCGATTCAATAAAACT
GTGCGAGTGTGTGGAACTGTGACCTTCATCTTTCAGATGGTGATCTACATGGGAGTTGTG
CTCTATGCTCCGTCATTGGCTCTCAATGCAGTGACTGGCTTTGATCTGTGGCTGTCCGTG
CTGGCCCTGGGCATTGTCTGTACCGTCTATACAGCTCTGGGTGGGCTGAAGGCCGTCATC
TGGACAGATGTGTTCCAGACACTGGTCATGTTCCTCGGGCAGCTGGCAGTTATCATCGTG
GGGTCAGCCAAGGTGGGCGGCTTGGGGCGTGTGTGGGCCGTGGCTTCCCAGCACGGCCGC
ATCTCTGGGTTTGAGCTGGATCCAGACCCCTTTGTGCGGCACACCTTCTGGACCTTGGCC
TTCGGGGGTGTCTTCATGATGCTCTCCTTATACGGGGTGAACCAGGCTCAGGTGCAGCGG
TACCTCAGTTCCCGCACGGAGAAGGCTGCTGTGCTCTCCTGTTATGCAGTGTTCCCCTTC
CAGCAGGTGTCCCTCTGCGTGGGCTGCCTCATTGGCCTGGTCATGTTCGCGTATTACCAG
GAGTATCCCATGAGCATTCAGCAGGCTCAGGCAGCCCCAGACCAGTTCGTCCTGTACTTT
GTGATGGATCTCCTGAAGGGCCTGCCAGGCCTGCCAGGGCTCTTCATTGCCTGCCTCTTC
AGCGGCTCTCTCAGCACTATATCCTCTGCTTTTAATTCATTGGCAACTGTTACGATGGAA
GACCTGATTCGACCTTGGTTCCCTGAGTTCTCTGAAGCCCGGGCCATCATGCTTTCCAGA
GGCCTTGCCTTTGGCTATGGGCTGCTTTGTCTAGGAATGGCCTATATTTCCTCCCAGATG
GGACCTGTGCTGCAGGCAGCAATCAGCATCTTTGGCATGGTTGGGGGACCGCTGCTGGGA
CTCTTCTGCCTTGGAATGTTCTTTCCATGTGCTAACCCTCCTGGTGCTGTTGTGGGCCTG
TTGGCTGGGCTCGTCATGGCCTTCTGGATTGGCATCGGGAGCATCGTGACCAGCATGGGC
TTCAGCATGCCACCCTCTCCCTCTAATGGGTCCAGCTTCTCCCTGCCCACCAATCTAACC
GTTGCCACTGTGACCACACTGATGCCCTTGACTACCTTCTCCAAGCCCACAGGGCTGCAG
CGGTTCTATTCCTTGTCTTACTTATGGTACAGTGCTCACAACTCCACCACAGTGATTGTG
GTGGGCCTGATTGTCAGTCTACTCACTGGGAGAATGCGAGGCCGGTCCCTGAACCCTGCA
ACCATTTACCCAGTGTTGCCAAAGCTCCTGTCCCTCCTTCCGTTGTCCTGTCAGAAGCGG
CTCCACTGCAGGAGCTACGGCCAGGACCACCTCGACACTGGCCTGTTTCCTGAGAAGCCG
AGGAATGGTGTGCTGGGGGACAGCAGAGACAAGGAGGCCATGGCCCTGGATGGCACAGCC
TATCAGGGGAGCAGCTCCACCTGCATCCTCCAGGAGACCTCCCTGTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
AF116241

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2p23

# Macromolecular_Interacting_Partner_6_SNPs:
rs1395; rs1064845; rs7081; rs1275530; rs1275528; rs6547496; rs2580759; rs1275529; rs1275522; rs1275521; rs2580761; rs1006898; rs1275525; rs1275527; rs1275526; rs1659685; rs41288805; rs12466181; rs11542419; rs1275523; rs1275524; rs4327199; rs35656364; rs2580758; rs996650; rs13424785; rs7424503; rs1275531; rs41288803; rs1985770; rs10638396; rs1275519; rs1298361; rs4309540; rs2580760; rs35824171; rs2014284; rs1008670; rs2580762; rs7420893; rs41288809; rs2735861; rs3072731; rs41288807; rs1882849; rs2735863; rs2735862; rs2580381; rs1044325; rs11126918; rs11608; rs11936; rs12465084; rs12469900; rs1275501; rs1275504; rs1275532; rs1275533; rs1275536; rs1275537; rs1275538; rs13383098; rs1659687; rs1659700; rs1659701; rs2078616; rs2289363; rs2735864; rs4617; rs4665373; rs4665374; rs4665958; rs724310; rs724311; rs7437

# Macromolecular_Interacting_Partner_6_General_References:
10329687; 10334869

# Macromolecular_Interacting_Partner_6_References:
15905112; 16749865; 17038304

End of HMDB00030

Beginning of HMDB00031
# Accession_No:
HMDB00031

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 16:01:17

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Androsterone

# Description:
Androsterone (ADT) is a steroid hormone with weak androgenic activity.  It is important for sex determination in the fetus and the maintenance of genitalia function.  Androsterone is a metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.  Androsterone is made in the liver from the metabolism of testosterone. It was first isolated in 1931, by Adolf Friedrich Johann Butenandt and Kurt Tscherning. They distilled over 17000 liters of male urine, from which they got 50 milligrams of crystalline androsterone, which was sufficient to find that the chemical formula was very similar to estrone. -- Wikipedia

# Synonyms:
(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one; (3alpha,5alpha)-3-hydroxy-Androstan-17-one; 3-Epihydroxyetioallocholan-17-one; 3-Hydroxyandrostan-17-one; 3-alpha-Hydroxy-17-androstanone; 3-alpha-Hydroxy-5-alpha-androstan-17-one; 3-alpha-Hydroxy-5-alpha-androstane-17-one; 3-alpha-Hydroxyetioallocholan-17-one; 3-alpha-hydroxy-5alpha-Androstan-17-one; 3-hydroxy-(3-alpha,5-alpha)-Androstan-17-one; 3a-Hydroxyetioallocholan-17-one; 3alpha-Hydroxy-17-androstanone; 3alpha-Hydroxy-5alpha-androstan-17-one; 3alpha-Hydroxyetioallocholan-17-one; 5-alpha-Androstan-3-alpha-ol-17-one; 5-alpha-Androstane-3alpha-ol-17-one; 5-alpha-Androsterone; 5a-Androstan-3a-ol-17-one; 5a-Androstane-3a-ol-17-one; 5a-Androsterone; 5alpha-Androstane-3alpha-ol-17-one; 5alpha-Androsterone; Androkinine; Androstanon-3-alpha-ol-17-one; Androsterone; Androtine; Atromide ICI; cis-Androsterone

# Chemical_IUPAC_Name:
(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one

# Chemical_Formula:
C19H30O2

# Chemical_Structure:
tbl_chemical:::HMDB00031_ZOOM.png:::1192831414786180

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00031_THUMB.png:::119283141268477404

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; secondary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
290.22458

# Molecular_Weight_Avg:
290.44031

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CCC4CC(O)CCC34C)C1CCC2=O

# KEGG_Compound_ID:
C00523

# BioCyc_ID:
ANDROSTERONE

# PubChem_CID:
5879

# PubChem_SID:
7885731; 11486037; 10321647; 8145036; 11532920; 11466439; 4266383; 8153634; 3806; 148682; 11467559; 585814; 854588; 75252; 3138568; 841382

# OMIM_ID:
Not Available

# Metagene_ID:
3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: 95; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
35244

# Wikipedia_ID:
Androsterone

# METLIN_ID:
2797

# Ref_ID:
3802509; 6211346; 10625505; 158859; 7245287; 15946323; 15894033; 3162156; 2946134; 15954157; 16078844; 79632

# ChEBI_ID:
16032

# CAS_Registry_Number:
53-41-8

# InChI:
InChI=1/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12?,13-,14+,15+,16+,18+,19+/m1/s1

# Synthesis_Reference:
Marker, R.E. (1935) JACS 57:1755-1756

# Melting_Point:
185 oC

# Melting_Point_predicted:
118.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.012 mg/mL at 23 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
6.37e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
3.69 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
3.71 [Predicted by ALOGPS]; 4.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Androsterone.pdf:::1132562191066860960

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Androsterone.mol:::1132723802359819972

# SDF_File_[Text]:
tbl_chemical:::HMDB00031.sdf:::11928314070852731

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00031.pdb:::119283141100456043

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::Androsterone_00031_CDCl3_noesy1d_1feb07.fid.zip:::117078848418381840

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050118_P00_08_IS_1DP_Assigned.png:::117078848421922730

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050118_P00_08_1S_2DHSQC_98.png:::114835597534634235

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050118_P00_08_IS_2DHSQC_98.zip:::114835597538116709

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050118_P00_08_1S_2DHSQC_98_Assigned.png:::116190061621084035

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Androsterone.gif:::1132732100343922805

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00031_peaks.txt:::1156309497626920121

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Androsterone_C.gif:::1132737661213513112

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00031_peaks.txt:::1156310689436126235

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00031.png:::116543399568370957; Medium Energy:tbl_ms:::HMDB00031.png:::1165433870595200662; High Energy:tbl_ms:::HMDB00031.png:::1165433912609133613

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum; Extracellular

# Tissue_Location:
Intestine; Most Tissues; Primarily Liver; Prostate; Testis

# deuterated:
No

# Biofluid_Location:
CSF; Urine

# Concentration_[Normal]:
Urine	0.66	umol/mmol_creatinine	Children:1-13_yrs_old	Both	Normal	2946134
Urine	6.69 +/- 1.65	umol/mmol_creatinine	Adult:>18_yrs_old	Female	Normal	6211346
Cerebrospinal_Fluid(CSF)	0.00016 +/- 0.000058	uM	Adult:>18_yrs_old	Male	Normal	10625505
N/A	0.041 +/-0.017	uM	Adult:>18_yrs_old	Both	Normal	79632


# Concentration_[Abnormal]:
N/A	0.014 +/- 0.001	uM	Adult:>18_yrs_old	Both	Benign Prostatic Hyperplasia (Prostate tissue)	79632


# Associated_Disorders:
21-Hydroxylase Deficiency (CYP21); 3-Beta-Hydroxysteroid Dehydrogenase Deficiency; Benign Prostatic Hyperplasia (Prostate tissue); Hyperinsulinemia; Hypothyroidism; Ullrich Turner Syndrome

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism;Prostaglandin and leukotriene metabolism;Bile acid biosynthesis;C21-Steroid hormone metabolism

# Pathway_Images:
;;;;;;

# KEGG_Images:
map00040;map00150;map00500;map00860;map0059;map00120;map00140

# Pathway_Graphs:
;;;;;;

# Pathway_SBMLs:
;;;;;;

# Metabolic_Enzyme_1_ID:
5722

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_1_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_1_Gene_Name:
UGT2B15

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_1_Number_of_Residues:
530

# Metabolic_Enzyme_1_Molecular_Weight:
60989

# Metabolic_Enzyme_1_Theoretical_pI:
9.04

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_1_Signals:
1-23

# Metabolic_Enzyme_1_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_1_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT2B15

# Metabolic_Enzyme_1_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_1_Locus:
4q13

# Metabolic_Enzyme_1_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_1_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5596

# Metabolic_Enzyme_2_Name:
Aldo-keto reductase family 1 member C3

# Metabolic_Enzyme_2_Synonyms:
Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; 3-alpha- hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Prostaglandin F synthase; PGFS; Estradiol 17-beta-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; Chlordecone reductase homolog HAKRb; HA1753; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD3; DD-3

# Metabolic_Enzyme_2_Gene_Name:
AKR1C3

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldoketo reductase family 1 member C3
MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY

# Metabolic_Enzyme_2_Number_of_Residues:
323

# Metabolic_Enzyme_2_Molecular_Weight:
36845

# Metabolic_Enzyme_2_Theoretical_pI:
8.06

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. Functions as a bi-directional 3alpha-, 17beta- and 20alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone

# Metabolic_Enzyme_2_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_2_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.3.1.20;EC 1.1.1.213;

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4261711

# Metabolic_Enzyme_2_SwissProt_ID:
AK1C3_HUMAN (P42330)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AKR1C3

# Metabolic_Enzyme_2_Geneatlas_id:
AKR1C3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:386

# Metabolic_Enzyme_2_PDB_ID:
1XF0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>972 bp
ATGGATTCCAAACAGCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTTGAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTATCAAACTTCAACCGCAGGCAGCTGGAGATCATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTCCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
S68288

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10p15-p14

# Metabolic_Enzyme_2_SNPs:
rs12529; rs1804062; rs35575889; rs34186955; rs35961894; rs12387; rs1937839; rs28943574; rs7741; rs3209896; rs1937840; rs2801883; rs2275928; rs2245191; rs1937843; rs2154309; rs9329316; rs11252951; rs4641368; rs4478887; rs7076063; rs4242785; rs10508294; rs4512728; rs10904418; rs9888062; rs2298305; rs2518049; rs4881400; rs7917546; rs2801882; rs17173403; rs7091485; rs2154307; rs10795245; rs11252945; rs11252941; rs33921818; rs17155732; rs1937841; rs11252942; rs33979906; rs11252943; rs12769666; rs12775701; rs9888075; rs10508293; rs11252944; rs2154306; rs10160019; rs3750566; rs11252950; rs10904416; rs12242350; rs11252939; rs35768949; rs12267712; rs35567055; rs34760938; rs34936429; rs36050091; rs4987101; rs17396032; rs11252940; rs7090349; rs4559587; rs35955223; rs12244591; rs11252946; rs4347280; rs34291069; rs36003741; rs12775913; rs17134355; rs34320249; rs7920141; rs36204597; rs2339; rs34140485; rs4584484; rs10904417; rs4584485; rs34304688; rs12775922; rs35983920; rs9329315; rs35047456; rs4264066; rs12782982; rs12244584; rs10904419; rs34335319; rs3763676; rs10904421; rs11818810; rs10904415; rs11252935; rs1937845; rs7894034; rs2518047; rs17134359; rs11252936; rs36000531; rs34516592; rs34722940; rs35483669; rs35531692; rs11252937; rs28942669; rs11551178; rs1131132; rs4987102; rs41306308; rs1804059; rs28943579; rs7342072; rs17849485; rs1131124; rs1804061; rs1804060; rs6581; rs28943581; rs28943582; rs35460332; rs35951787; rs35498365; rs34464507; rs3996506; rs11273607; rs34805426; rs35558480; rs34376012; rs12219397; rs1937844; rs4987103; rs12775924; rs34401009; rs35550189; rs11252947; rs7913166; rs35859199; rs34365063; rs35516441; rs7089963; rs2298304; rs41306310; rs35338655; rs34942947; rs34429432; rs12413055; rs34774984; rs11252948; rs35174293; rs10637298; rs5782801; rs28758366; rs7090071; rs34977292; rs10654845; rs35681139; rs10637297; rs11270349; rs35857003; rs11252938; rs3216070; rs35888676; rs34948891; rs34791059; rs5782800; rs11252949; rs34835891; rs35156069; rs11592217; rs34747896; rs28943578; rs34819103; rs11819187; rs5782802; rs34506108; rs34070010; rs35613411; rs35843850; rs28943577; rs36201177; rs35754932; rs1937846; rs35143522; rs28943576; rs35288974; rs10904422; rs10904423; rs10904428; rs11252931; rs11252932; rs11252934; rs11252955; rs11252960; rs11813521; rs12263243; rs12354530; rs12414038; rs17134288; rs1937847; rs1937848; rs1937849; rs1937905; rs1937906; rs2211624; rs2211625; rs2211630; rs2226260; rs34706100; rs4636560; rs4880708; rs4880709; rs4880710; rs7068685; rs7070041; rs7086771; rs7088288; rs7477623; rs7478099; rs7904863; rs7917079; rs7921327

# Metabolic_Enzyme_2_General_References:
8274401; 7650035; 7626489; 9415401; 10622721; 10557352; 10672042; 11165022; 7788527; 9927279

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5731

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_3_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_3_Gene_Name:
UGT2B17

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
61096

# Metabolic_Enzyme_3_Theoretical_pI:
8.73

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-23

# Metabolic_Enzyme_3_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_3_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT2B17

# Metabolic_Enzyme_3_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
8798464; 9364925

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5732

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_4_Gene_Name:
UGT1A6

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
532

# Metabolic_Enzyme_4_Molecular_Weight:
60751

# Metabolic_Enzyme_4_Theoretical_pI:
8.55

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-26

# Metabolic_Enzyme_4_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_4_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A6

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_4_Chromosome_Location:
Not Available

# Metabolic_Enzyme_4_Locus:
Not Available

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5696

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_5_Gene_Name:
UGT2B4

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_5_Number_of_Residues:
528

# Metabolic_Enzyme_5_Molecular_Weight:
60513

# Metabolic_Enzyme_5_Theoretical_pI:
8.75

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_5_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B4

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_5_Locus:
4q13

# Metabolic_Enzyme_5_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_5_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5726

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_6_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_6_Gene_Name:
UGT1A9

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_6_Number_of_Residues:
530

# Metabolic_Enzyme_6_Molecular_Weight:
59942

# Metabolic_Enzyme_6_Theoretical_pI:
7.96

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-25

# Metabolic_Enzyme_6_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_6_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT1A9

# Metabolic_Enzyme_6_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Microsome

# Metabolic_Enzyme_6_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_6_Chromosome_Location:
Not Available

# Metabolic_Enzyme_6_Locus:
Not Available

# Metabolic_Enzyme_6_SNPs:
Not Available

# Metabolic_Enzyme_6_General_References:
1910331; 11434514

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5623

# Metabolic_Enzyme_7_Name:
Aldo-keto reductase family 1 member C1

# Metabolic_Enzyme_7_Synonyms:
20-alpha- hydroxysteroid dehydrogenase; 20-alpha-HSD; Trans- 1,2-dihydrobenzene-1,2-diol dehydrogenase; High- affinity hepatic bile acid-binding protein; HBAB; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2

# Metabolic_Enzyme_7_Gene_Name:
AKR1C1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldoketo reductase family 1 member C1
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY

# Metabolic_Enzyme_7_Number_of_Residues:
323

# Metabolic_Enzyme_7_Molecular_Weight:
36789

# Metabolic_Enzyme_7_Theoretical_pI:
7.99

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Converts progesterone to its inactive form, 20alpha- dihydroxyprogesterone (20alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. May play a role in myelin formation

# Metabolic_Enzyme_7_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_7_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.1.1.149;EC 1.3.1.20

# Metabolic_Enzyme_7_GenBank_ID_Protein:
181549

# Metabolic_Enzyme_7_SwissProt_ID:
AK1C1_HUMAN (Q04828)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
AKR1C1

# Metabolic_Enzyme_7_Geneatlas_id:
AKR1C1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:384

# Metabolic_Enzyme_7_PDB_ID:
1MRQ

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_7_Gene_Sequence:
>972 bp
ATGGATTCGAAATATCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTG
GCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACGTGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M86609

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_7_Locus:
10p15-p14

# Metabolic_Enzyme_7_SNPs:
rs8483; rs35763015; rs35289491; rs7076886; rs7083234; rs3925947; rs4445550; rs3890593; rs2904802; rs2904804; rs2961611; rs7073738; rs3927919; rs7893456; rs12571627; rs3923936; rs7083246; rs7908994; rs4242782; rs2023630; rs35578180; rs1468085; rs7089378; rs3927918; rs10128163; rs6650153; rs7916644; rs5001364; rs2904799; rs6601881; rs3927917; rs3927913; rs12264914; rs11815346; rs7074155; rs1468084; rs12263850; rs12256271; rs7916500; rs3890643; rs3898029; rs1139139; rs4881373; rs2904795; rs11252852; rs1138575; rs1138569; rs1138570; rs1138571; rs1138576; rs15986; rs1138567; rs1138600; rs1138573; rs11548049; rs1138566; rs7097713; rs1138574; rs7069696; rs10562538; rs12263706; rs3925302; rs6143754; rs12250190; rs35909591; rs11252855; rs34344919; rs3923937; rs10685217; rs34098462; rs35308766; rs33990529; rs12264439; rs36033871; rs7069625; rs5782795; rs10595294; rs41305675; rs10664133; rs41298222; rs10128236; rs3927914; rs5010127; rs3930966; rs11330324; rs2961613; rs2518036; rs12254797; rs7087263; rs41305663; rs41314242; rs35816821; rs28451635; rs41298224; rs35617876; rs12773163; rs7085135; rs12256328; rs41305667; rs2904798; rs41314625; rs2961612; rs28464583; rs28580360; rs35691694; rs5001363; rs2904801; rs3930965; rs2518035; rs5782794; rs41305661; rs12241237; rs11252853; rs2854470; rs11310552; rs41305677; rs11252864; rs2904800; rs2904803; rs34581211; rs4255441; rs6601882; rs6601887; rs6601888; rs7068923; rs7909151; rs7914666; rs7915338

# Metabolic_Enzyme_7_General_References:
8486699; 8132567; 7626489; 10672042; 11013348; 8274401; 8172617; 12899831

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5730

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_8_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_8_Gene_Name:
UGT1A10

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
530

# Metabolic_Enzyme_8_Molecular_Weight:
59810

# Metabolic_Enzyme_8_Theoretical_pI:
7.31

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_8_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A10

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_8_Locus:
2q37

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
9271343; 11434514

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5727

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_9_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_9_Gene_Name:
UGT1A8

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_9_Number_of_Residues:
530

# Metabolic_Enzyme_9_Molecular_Weight:
59742

# Metabolic_Enzyme_9_Theoretical_pI:
7.73

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_9_Signals:
1-25

# Metabolic_Enzyme_9_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_9_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT1A8

# Metabolic_Enzyme_9_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_9_Chromosome_Location:
Not Available

# Metabolic_Enzyme_9_Locus:
Not Available

# Metabolic_Enzyme_9_SNPs:
Not Available

# Metabolic_Enzyme_9_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5687

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B28

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
60907

# Metabolic_Enzyme_10_Theoretical_pI:
8.80

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-24

# Metabolic_Enzyme_10_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_10_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B28

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_10_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_10_General_References:
11300766

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5719

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_11_Gene_Name:
UGT1A4

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60026

# Metabolic_Enzyme_11_Theoretical_pI:
8.68

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_11_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A4

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5728

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_12_Gene_Name:
UGT1A3

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
534

# Metabolic_Enzyme_12_Molecular_Weight:
60339

# Metabolic_Enzyme_12_Theoretical_pI:
8.28

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-28

# Metabolic_Enzyme_12_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_12_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A3

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q37

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1339448; 11434514

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5624

# Metabolic_Enzyme_13_Name:
Aldo-keto reductase family 1 member C2

# Metabolic_Enzyme_13_Synonyms:
Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; Type III 3- alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Dihydrodiol dehydrogenase 2; DD2

# Metabolic_Enzyme_13_Gene_Name:
AKR1C2

# Metabolic_Enzyme_13_Protein_Sequence:
>Aldoketo reductase family 1 member C2
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY

# Metabolic_Enzyme_13_Number_of_Residues:
323

# Metabolic_Enzyme_13_Molecular_Weight:
36736

# Metabolic_Enzyme_13_Theoretical_pI:
7.55

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Works in concert with the 5alpha/5beta-steroid reductases to convert steroid hormones into the 3alpha/5alpha and 3alpha/5beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT) to 5-alpha-androstane-3alpha,17beta-diol (3-alpha-diol)

# Metabolic_Enzyme_13_Pathway:
Not Available

# Metabolic_Enzyme_13_Reaction:
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.3.1.20;EC 1.1.1.213

# Metabolic_Enzyme_13_GenBank_ID_Protein:
531160

# Metabolic_Enzyme_13_SwissProt_ID:
AK1C2_HUMAN (P52895)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
AKR1C2

# Metabolic_Enzyme_13_Geneatlas_id:
AKR1C2

# Metabolic_Enzyme_13_hgnc_id:
HGNC:385

# Metabolic_Enzyme_13_PDB_ID:
1IHI

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_13_Gene_Sequence:
>972 bp
ATGGATTCGAAATACCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTCTAGAGGCCGTCAAATTG
GCAATAGAAGCCGGGTTCCACCATATTGATTCTGCACATGTTTACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGAGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGACTATGTTGACCTCTATCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACGTGGGAGGCCATGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCACAGGCTGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCATCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
U05598

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_13_Locus:
10p15-p14

# Metabolic_Enzyme_13_SNPs:
rs2854482; rs3207909; rs1937863; rs1937855; rs4620617; rs7088486; rs12769178; rs3902926; rs7086564; rs1937865; rs4375350; rs10795218; rs1937868; rs1937856; rs2895050; rs7088509; rs7082231; rs1937892; rs7075514; rs1937889; rs1937867; rs2801886; rs4601669; rs2398174; rs7915365; rs7073591; rs7098927; rs2518040; rs1937870; rs1937860; rs10795221; rs7091798; rs2226258; rs1937854; rs2398175; rs11252885; rs1937866; rs2801885; rs11252879; rs1937890; rs7091942; rs7073715; rs12146227; rs7087112; rs7099721; rs10904388; rs1937861; rs4529810; rs7073878; rs11252884; rs1937853; rs1937862; rs7086573; rs10795220; rs1937891; rs12571988; rs1132229; rs4881375; rs2854494; rs2854466; rs2904806; rs2801891; rs9804390; rs2518045; rs9804392; rs10904387; rs3885233; rs3900662; rs2904812; rs4881372; rs4344395; rs11819128; rs2275929; rs2801926; rs3885232; rs9732372; rs2801897; rs2801893; rs1937872; rs2854491; rs11819348; rs11252869; rs10904385; rs2518039; rs2518044; rs10904384; rs12764498; rs10904386; rs2854467; rs2997319; rs2904807; rs11252876; rs1937873; rs11812106; rs12355347; rs4300311; rs2854490; rs2801895; rs7912100; rs3927920; rs11252870; rs2801896; rs2904808; rs11816204; rs9733478; rs1937888; rs10904383; rs1937884; rs1937886; rs10618; rs3207898; rs2518042; rs13933; rs3207901; rs3207905; rs2854486; rs2518043; rs8493; rs13945; rs3207904; rs13840; rs3207903; rs17846645; rs8314; rs41316041; rs2854468; rs7069541; rs2854469; rs2398165; rs28488494; rs12784525; rs2398172; rs2398170; rs1937859; rs11252882; rs2398177; rs2895048; rs2895051; rs12782334; rs35322662; rs4363495; rs1138743; rs36026148; rs28590375; rs34805072; rs1937857; rs3020658; rs11252880; rs2398169; rs3020659; rs28594873; rs2398166; rs1138738; rs1937852; rs2895052; rs11252883; rs2895045; rs1138758; rs2895049; rs2398164; rs2801884; rs35454481; rs35486838; rs1937851; rs2854479; rs1937871; rs28711900; rs12782301; rs3902925; rs4472836; rs12784556; rs2398173; rs2398176; rs28613695; rs1937858; rs7082227; rs35264282; rs7085982; rs28567035; rs2398171; rs3020660; rs1138741; rs11252881; rs2398178; rs3020657; rs10904389; rs2895047; rs11252878; rs2398163; rs35166812; rs3020656; rs2895046; rs1138759; rs35722966; rs2518041; rs2895053; rs10904390; rs4529809; rs10692238; rs2398168; rs2515679; rs1138745; rs6601877; rs2398167; rs28651095; rs1937869; rs2801928; rs36076403; rs11252875; rs2854478; rs34515072; rs3926326; rs2904811; rs3020668; rs2854472; rs12267144; rs34792441; rs2997315; rs3926325; rs11380937; rs2854474; rs35979147; rs11252871; rs12357650; rs11812357; rs2854492; rs2997320; rs34747355; rs11813483; rs34612007; rs41304583; rs2854476; rs2854481; rs4307630; rs2997321; rs2801887; rs12258087; rs11819572; rs34776622; rs2490065; rs11252873; rs3020664; rs34448751; rs2997323; rs2997314; rs3020666; rs2904809; rs2854487; rs11813470; rs2854484; rs2854485; rs5782796; rs3020667; rs7902108; rs2997322; rs11818926; rs2801927; rs2518038; rs10643636; rs2854473; rs7896657; rs2854477; rs11252872; rs2854480; rs2854489; rs2904810; rs2997318; rs2801892; rs2801929; rs12772460; rs41313802; rs2854475; rs2997324; rs41304573; rs2854488; rs2997316; rs2518034; rs2854493; rs4492708; rs3020665; rs34371823; rs7092546; rs41313806; rs11819371; rs35767584; rs34716664; rs11252874; rs28571848; rs11517324; rs1937887; rs34907157; rs10710137; rs11252866; rs28568332; rs34040160; rs12253443; rs12252183; rs11252864; rs11252887; rs11252889; rs12411321; rs12570475; rs17134158; rs2398193; rs4143630; rs4143631; rs6601887; rs6601888; rs7068923; rs7909151; rs7915338

# Metabolic_Enzyme_13_General_References:
8011662; 8274401; 7959017; 9716498; 10672042

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5725

# Metabolic_Enzyme_14_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_14_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_14_Gene_Name:
UGT1A1

# Metabolic_Enzyme_14_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_14_Number_of_Residues:
533

# Metabolic_Enzyme_14_Molecular_Weight:
59592

# Metabolic_Enzyme_14_Theoretical_pI:
8.09

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_14_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_14_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_14_Signals:
1-25

# Metabolic_Enzyme_14_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_14_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_14_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
UGT1A1

# Metabolic_Enzyme_14_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_14_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Microsome

# Metabolic_Enzyme_14_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_14_Locus:
2q37

# Metabolic_Enzyme_14_SNPs:
Not Available

# Metabolic_Enzyme_14_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5741

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_15_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_15_Gene_Name:
UGT1A7

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_15_Number_of_Residues:
530

# Metabolic_Enzyme_15_Molecular_Weight:
59819

# Metabolic_Enzyme_15_Theoretical_pI:
7.85

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-25

# Metabolic_Enzyme_15_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_15_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT1A7

# Metabolic_Enzyme_15_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_15_Locus:
2q37

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5721

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_16_Gene_Name:
UGT2B7

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_16_Number_of_Residues:
529

# Metabolic_Enzyme_16_Molecular_Weight:
60695

# Metabolic_Enzyme_16_Theoretical_pI:
8.45

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-23

# Metabolic_Enzyme_16_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_16_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT2B7

# Metabolic_Enzyme_16_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_16_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_16_Locus:
4q13

# Metabolic_Enzyme_16_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_16_General_References:
2159463; 11186130

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5303

# Metabolic_Enzyme_17_Name:
Aldo-keto reductase family 1 member C4

# Metabolic_Enzyme_17_Synonyms:
Chlordecone reductase; CDR; 3-alpha-hydroxysteroid dehydrogenase type I; 3-alpha-HSD1; Dihydrodiol dehydrogenase 4; DD4; HAKRA

# Metabolic_Enzyme_17_Gene_Name:
AKR1C4

# Metabolic_Enzyme_17_Protein_Sequence:
>Aldoketo reductase family 1 member C4
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY

# Metabolic_Enzyme_17_Number_of_Residues:
323

# Metabolic_Enzyme_17_Molecular_Weight:
37095

# Metabolic_Enzyme_17_Theoretical_pI:
7.19

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3alpha,17beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route

# Metabolic_Enzyme_17_Pathway:
map00120  Bile acid biosynthesis;
 map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_17_Reaction:
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 1.1.1.225;EC 1.1.1.50

# Metabolic_Enzyme_17_GenBank_ID_Protein:
4261710

# Metabolic_Enzyme_17_SwissProt_ID:
AK1C4_HUMAN (P17516)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AKR1C4

# Metabolic_Enzyme_17_Geneatlas_id:
AKR1C4

# Metabolic_Enzyme_17_hgnc_id:
HGNC:387

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_17_Gene_Sequence:
>972 bp
ATGGATCCCAAATATCAGCGTGTAGAGCTAAATGATGGTCATTTCATGCCCGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGGAACAGAGCTGTAGAGGTCACCAAATTA
GCAATAGAAGCTGGCTTCCGCCATATTGATTCTGCTTATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCACTTTCTTTCAACCACAGATGGTCCAACCAGCCTTGGAA
AGCTCACTGAAAAAACTTCAACTGGACTATGTTGACCTCTATCTTCTTCATTTCCCAATG
GCTCTCAAGCCAGGTGAGACGCCACTACCAAAAGATGAAAATGGAAAAGTAATATTCGAC
ACAGTGGATCTCTCTGCCACATGGGAGGTCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCAAACTTCAACTGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCTTACCTCAACCAGAGC
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCCACAGTGCTCTGGGA
ACCCAACGACATAAACTATGGGTGGACCCAAACTCCCCAGTTCTTTTGGAGGACCCAGTT
CTTTGTGCCTTAGCAAAGAAACACAAACGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGGATCAGAGAGAAC
ATCCAGGTTTTTGAATTCCAGTTGACATCAGAGGATATGAAAGTTCTAGATGGTCTAAAC
AGAAATTATCGATATGTTGTCATGGATTTTCTTATGGACCATCCTGATTATCCATTTTCA
GATGAATATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
S68287

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10p15-p14

# Metabolic_Enzyme_17_SNPs:
rs3829125; rs17134592; rs11253043; rs17306779; rs2398157; rs17307359; rs1413622; rs10458795; rs1931679; rs7085249; rs1413781; rs1413624; rs2050308; rs7921838; rs7088788; rs6601927; rs4881412; rs6601924; rs7078211; rs12247748; rs11594448; rs7101071; rs17134526; rs7092102; rs3750572; rs10795255; rs3750569; rs12762017; rs1413780; rs2225695; rs3750567; rs7070862; rs1832007; rs10904440; rs10795256; rs3750568; rs3750571; rs7074004; rs1889457; rs4881413; rs7475281; rs7908297; rs11253046; rs7475279; rs17134531; rs7083869; rs7897431; rs1334475; rs2151896; rs7087111; rs17134533; rs1334474; rs11594520; rs12257364; rs17134589; rs4881411; rs11594428; rs4098025; rs17134585; rs11253045; rs7477230; rs17134523; rs34463109; rs34030369; rs11253042; rs7100517; rs12771394; rs1831977; rs11253041; rs2398160; rs1334473; rs2210681; rs7477114; rs7893850; rs36048054; rs11596429; rs3996505; rs7099303; rs4478889; rs4427472; rs11253047; rs2095367; rs12264733; rs7099651; rs2050309; rs4612705; rs35950499; rs17134588; rs12252186; rs4880716; rs6601928; rs7072596; rs17134601; rs11253048; rs17134604; rs4880718; rs17851824; rs3038974; rs1413623; rs35960357; rs11327365; rs11268534; rs2398158; rs3039101; rs7096122; rs3750570; rs2398159; rs5782814; rs11253044; rs35917693; rs10600924; rs9423555; rs4350268; rs7909380; rs10586998; rs7915357; rs41305665; rs4420164; rs4424574; rs5782812; rs4642979; rs915135; rs34826816; rs12784055; rs3039090; rs35154936; rs2151895; rs35283379; rs1334472; rs7912751; rs7909379; rs2104997; rs5782813; rs12776936; rs2065661; rs10458789; rs34351269; rs11253040; rs1811960; rs3812617; rs11402533; rs12774775; rs10711188; rs11291778; rs11427518; rs3841204; rs3812616; rs10795253; rs10904441; rs10904442; rs11253038; rs12253078; rs12267307; rs12269559; rs12360316; rs12775790; rs1334466; rs17134607; rs17134608; rs17134610; rs17134614; rs17134616; rs17134617; rs17155741; rs17306485; rs1889456; rs1931681; rs2151901; rs6422393; rs6601929; rs7091223; rs7096360; rs9423382

# Metabolic_Enzyme_17_General_References:
8274401; 7650035; 7626489; 10634139; 10672042; 11158055; 2187532; 8172617; 1530633

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5733

# Metabolic_Enzyme_18_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_18_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_18_Gene_Name:
UGT1A5

# Metabolic_Enzyme_18_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_18_Number_of_Residues:
534

# Metabolic_Enzyme_18_Molecular_Weight:
60072

# Metabolic_Enzyme_18_Theoretical_pI:
8.14

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_18_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_18_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_18_Signals:
1-28

# Metabolic_Enzyme_18_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_18_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_18_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
UGT1A5

# Metabolic_Enzyme_18_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_18_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Microsome

# Metabolic_Enzyme_18_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_18_Locus:
2q37

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
1339448; 11434514

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5724

# Metabolic_Enzyme_19_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_19_Synonyms:
Not Available

# Metabolic_Enzyme_19_Gene_Name:
UGT2A1

# Metabolic_Enzyme_19_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_19_Number_of_Residues:
527

# Metabolic_Enzyme_19_Molecular_Weight:
59873

# Metabolic_Enzyme_19_Theoretical_pI:
9.29

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_19_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_19_Signals:
1-20

# Metabolic_Enzyme_19_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_19_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_19_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
UGT2A1

# Metabolic_Enzyme_19_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_19_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Membrane

# Metabolic_Enzyme_19_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_19_Locus:
4q13

# Metabolic_Enzyme_19_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_19_General_References:
10359671

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5734

# Metabolic_Enzyme_20_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_20_Synonyms:
UDPGT

# Metabolic_Enzyme_20_Gene_Name:
UGT2B11

# Metabolic_Enzyme_20_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_20_Number_of_Residues:
529

# Metabolic_Enzyme_20_Molecular_Weight:
61039

# Metabolic_Enzyme_20_Theoretical_pI:
9.29

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_20_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_20_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_20_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_20_Signals:
1-21

# Metabolic_Enzyme_20_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_20_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_20_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
UGT2B11

# Metabolic_Enzyme_20_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_20_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Microsome

# Metabolic_Enzyme_20_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_20_Locus:
4q13.2

# Metabolic_Enzyme_20_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_20_General_References:
9675083

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5583

# Metabolic_Enzyme_21_Name:
Bile salt sulfotransferase

# Metabolic_Enzyme_21_Synonyms:
Hydroxysteroid Sulfotransferase; HST; Dehydroepiandrosterone sulfotransferase; DHEA-ST; ST2; ST2A3

# Metabolic_Enzyme_21_Gene_Name:
SULT2A1

# Metabolic_Enzyme_21_Protein_Sequence:
>Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVP
IWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYL
MRNPRDVLVSGYFFWKNMKFI
KKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKN
FLLLSYEELKQDTGRTIEKICQFLGKTLEPEE
LNLILKNSSFQSMKENKMSNYSLLSVD
YVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRE
LFPWE

# Metabolic_Enzyme_21_Number_of_Residues:
285

# Metabolic_Enzyme_21_Molecular_Weight:
33780

# Metabolic_Enzyme_21_Theoretical_pI:
5.76

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Not Available

# Metabolic_Enzyme_21_Specific_Function:
Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands

# Metabolic_Enzyme_21_Pathway:
Not Available

# Metabolic_Enzyme_21_Reaction:
3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 2.8.2.14

# Metabolic_Enzyme_21_GenBank_ID_Protein:
306702

# Metabolic_Enzyme_21_SwissProt_ID:
ST2A1_HUMAN (Q06520)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
SULT2A1

# Metabolic_Enzyme_21_Geneatlas_id:
SULT2A1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:11458

# Metabolic_Enzyme_21_PDB_ID:
1OV4

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_21_Gene_Sequence:
>858 bp

ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATC
CGAAACCTTAA
GAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATAT
TGACTTACCCCAAATCAGGAAC
AAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCC
AAGGGGGATGCCAAGTGGATCCAATCTGTGCCC
ATCTGGGAGCGATCACCCTGGGTAGA
GAGTGAGATTGGGTATACAGCACTCAGTGAAAGCGAGAGTCCAC
GTTTATTCTCCTCCC
ACCTCCCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGAT
TTAT
CTCATGAGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAG
TTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGT
GCTATATGGGTCATGGT
TTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAA
ACTTCCTGTTACTGAGTTATGAGGAGCT
GAAACAGGACACAGGAAGAACCATAGAGAAG
ATCTGTCAATTCCTGGGAAAGACGTTAGAACCCGAAGAA
CTGAACTTAATTCTCAAGAA
CAGCTCCTTTCAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCC
TGAGTGTTG
ATTATGTAGTGGACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATC
A
CTTCACAGTGGCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGAT
CTTCCTCGAGAG
CTGTTCCCATGGGAATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
L20000

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_21_Locus:
19q13.3

# Metabolic_Enzyme_21_SNPs:
rs11569681; rs11569679; rs11569685; rs11083907; rs296365; rs11083903; rs296366; rs296367; rs2547238; rs2547241; rs212099; rs4149448; rs2910394; rs2547236; rs11083905; rs11671690; rs2547240; rs11083904; rs2637116; rs296364; rs2431829; rs296361; rs2431828; rs2431830; rs2547237; rs2910393; rs11083906; rs4149452; rs10425629; rs10426201; rs296362; rs10401763; rs296359; rs296363; rs2547235; rs7247968; rs9676884; rs212100; rs8113396; rs2547242; rs2451834; rs2547231; rs12461808; rs10425975; rs2547239; rs8108674; rs16972519; rs10420308; rs4149449; rs10425154; rs7256697; rs182420; rs296368; rs188440; rs2932766; rs10401229; rs7508610; rs10402030; rs17464626; rs177037; rs17851828; rs1131405; rs1131404; rs4149454; rs10416994; rs36012387; rs10676904; rs10048437; rs34884527; rs10697302; rs35135607; rs11668504; rs10425963; rs35486252; rs36196588; rs35795715; rs12461162; rs7251378; rs12985420; rs35150217; rs4149451; rs34559609; rs34468125; rs34642376; rs34027366; rs34692560; rs9304669; rs4149450; rs2637115; rs2547234; rs11352410; rs34339793; rs12151061; rs12975483; rs3936308; rs35243293; rs296360; rs2547233; rs2972624; rs35067360; rs28830294; rs2972622; rs35543847; rs35489406; rs4002939; rs35975330; rs177036; rs2910392; rs2972623; rs28505302; rs28762460; rs8104798; rs11569677; rs11569678; rs11569680; rs11569683; rs11569684; rs12461421; rs2547229; rs2910397; rs2910400; rs296381; rs296390; rs296391; rs296394; rs2972612; rs6509347; rs6509348; rs8105359

# Metabolic_Enzyme_21_General_References:
7678732; 1588921; 7589785; 7598806; 7710689; 1520333

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5720

# Metabolic_Enzyme_22_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_22_Synonyms:
UDPGT

# Metabolic_Enzyme_22_Gene_Name:
UGT2B10

# Metabolic_Enzyme_22_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_22_Number_of_Residues:
528

# Metabolic_Enzyme_22_Molecular_Weight:
60775

# Metabolic_Enzyme_22_Theoretical_pI:
9.40

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_22_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_22_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_22_Signals:
1-23

# Metabolic_Enzyme_22_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_22_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
UGT2B10

# Metabolic_Enzyme_22_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_22_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Microsome

# Metabolic_Enzyme_22_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_22_Locus:
4q13.2

# Metabolic_Enzyme_22_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_22_General_References:
8333863

# Metabolic_Enzyme_22_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5818

# Macromolecular_Interacting_Partner_1_Name:
Dehydrogenase/reductase SDR family member 8 precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17-beta- HSD XI; 17betaHSDXI; 17bHSD11; 17betaHSD11; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Cutaneous T-cell lymphoma- associated antigen HD-CL-03; CTCL tumor antigen HD-CL-03

# Macromolecular_Interacting_Partner_1_Gene_Name:
DHRS8

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Dehydrogenase/reductase SDR family member 8 precursor
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK
SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN
AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP
FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE
EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIGYKMKAQ


# Macromolecular_Interacting_Partner_1_Number_of_Residues:
300

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32964

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.70

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Can convert androstan-3-alpha,17-beta-diol (3alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_1_Signals:
1-19

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
6318544

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
DHRS8_HUMAN (Q8NBQ5)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
DHRS8

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
DHRS8

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:22960

# Macromolecular_Interacting_Partner_1_PDB_ID:
1YB1

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein (Potential)

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>903 bp
ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAG
TCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTG
ATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA
AGCAAGCTGGTTCTCTGGGATATAAATAAGCATGGACTGGAGGAAACAGCTGCCAAATGC
AAGGGACTGGGTGCCAAGGTTCATACCTTTGTGGTAGACTGCAGCAACCGAGAAGATATT
TACAGCTCTGCAAAGAAGGTGAAGGCAGAAATTGGAGATGTTAGTATTTTAGTAAATAAT
GCTGGTGTAGTCTATACATCAGATTTGTTTGCTACACAAGATCCTCAGATTGAAAAGACT
TTTGAAGTTAATGTACTTGCACATTTCTGGACTACAAAGGCATTTCTTCCTGCAATGACG
AAGAATAACCATGGCCATATTGTCACTGTGGCTTCGGCAGCTGGACATGTCTCGGTCCCC
TTCTTACTGGCTTACTGTTCAAGCAAGTTTGCTGCTGTTGGATTTCATAAAACTTTGACA
GATGAACTGGCTGCCTTACAAATAACTGGAGTCAAAACAACATGTCTGTGTCCTAATTTC
GTAAACACTGGCTTCATCAAAAATCCAAGTACAAGTTTGGGACCCACTCTGGAACCCGAG
GAAGTGGTAAACAGGCTGATGCATGGGATTCTGACTGAGCAGAAGATGATTTTTATTCCA
TCTTCTATAGCTTTTTTAACAACATTGGAAAGGATCCTTCCTGAGCGTTTCCTGGCAGTT
TTAAAACGAAAAATCAGTGTTAAGTTTGATGCAGTTATTGGATATAAAATGAAAGCGCAA
TAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF126780

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q22.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs9991501; rs6531985; rs34025653; rs4438729; rs6853049; rs11732896; rs7691791; rs6840247; rs6531984; rs7667870; rs6845304; rs7682516; rs4585263; rs6849846; rs7688962; rs7665549; rs10028441; rs10213098; rs11946278; rs6849382; rs7679024; rs7662528; rs6531980; rs6531983; rs6531978; rs7690170; rs6857133; rs4574370; rs4635784; rs10022096; rs6811010; rs7677036; rs11721653; rs9307030; rs9991773; rs7682892; rs6818142; rs12649023; rs9307029; rs6531979; rs7665638; rs11946391; rs10050247; rs7685308; rs11734330; rs6833678; rs6531981; rs4469031; rs7664717; rs7698689; rs6817242; rs12642212; rs7671900; rs11097147; rs11737402; rs9684766; rs9307033; rs11097138; rs11939415; rs9996312; rs11727469; rs9283038; rs11097142; rs7665178; rs11931674; rs10002620; rs10433938; rs13150578; rs10049870; rs12108413; rs10856866; rs11930147; rs7697960; rs11946007; rs7684816; rs13435093; rs13102469; rs7690005; rs10856868; rs7661455; rs11930112; rs9993968; rs10856865; rs10049871; rs12510079; rs12386427; rs11097148; rs34853672; rs12643799; rs7696417; rs12505484; rs10856864; rs4443241; rs9715078; rs9307031; rs7667924; rs10433939; rs11930079; rs11097132; rs9715814; rs12505515; rs7677323; rs7689292; rs11097131; rs10025212; rs10004027; rs10222732; rs9684778; rs10049877; rs7676865; rs9968375; rs11946465; rs10856867; rs11934060; rs11930151; rs7665207; rs10433942; rs11939903; rs12644152; rs11939901; rs10032597; rs13138636; rs13138404; rs11549855; rs11549856; rs17850359; rs17850360; rs1127976; rs28654511; rs35289628; rs7681452; rs9968374; rs34915404; rs35304276; rs7677089; rs11505071; rs11097141; rs35707697; rs28566586; rs28379583; rs7660178; rs12054554; rs10433940; rs34923084; rs7698196; rs10049876; rs28427373; rs11314228; rs35567335; rs9761964; rs11097145; rs10695001; rs9968378; rs7696693; rs10012256; rs11390748; rs11379289; rs11505072; rs34215760; rs28889052; rs34864984; rs34512161; rs4435709; rs12499635; rs34571928; rs11097146; rs34601270; rs10029525; rs28709117; rs33949743; rs7675202; rs10618602; rs11418537; rs13126720; rs35829908; rs7671001; rs11097140; rs35724745; rs34571158; rs11398850; rs11097139; rs28433555; rs9684665; rs13146673; rs13133008; rs4257627; rs35359937; rs35581746; rs10433944; rs5860065; rs11097134; rs11495896; rs34360552; rs10627889; rs34847051; rs36085525; rs10856863; rs34733992; rs10003964; rs4422389; rs34828348; rs34740220; rs34311718; rs28514476; rs35122175; rs9968472; rs9799596; rs11458362; rs13124657; rs36047590; rs9684661; rs9685939; rs6839620; rs28696943; rs11722370; rs35787384; rs35905628; rs12386465; rs5860066; rs13138956; rs35699282; rs9761953; rs12386426; rs11097135; rs34342374; rs34976142; rs12505512; rs11304481; rs34331407; rs13105267; rs11097144; rs12649727; rs35056297; rs6839488; rs11409719; rs34513313; rs7675190; rs9799600; rs11443991; rs10592172; rs35077787; rs35602834; rs7436357; rs28706177; rs11369073; rs9684675; rs35017020; rs13105100; rs7677270; rs10433943; rs9307034; rs10028111; rs10546404; rs9761931; rs7678904; rs11097136; rs10034537; rs9715072; rs12054555; rs9684659; rs10684477; rs34984566; rs10000196; rs7697871; rs34827349; rs13132871; rs36084090; rs28415220; rs9307032; rs10433941; rs28610908; rs11375790; rs35482923; rs9684649; rs28655026; rs35761085; rs9715490; rs11097143; rs4331743; rs34224827; rs7661662; rs10706118; rs12512628; rs7694996; rs9884512; rs9760980; rs9760969; rs11097133; rs12054553; rs28445336; rs11097137; rs5860067; rs34851429; rs35478513; rs13119092; rs7697166; rs11305478; rs7671151; rs34137527; rs6840102; rs34109910; rs11514606; rs6817185; rs13126721; rs34525853; rs35898510; rs34694146; rs34505217; rs28366407; rs35236094; rs35123085; rs35767759; rs34521557; rs34714042; rs34538986; rs10010988; rs10023606; rs12500021; rs4388049; rs6840298; rs7674658; rs7699172

# Macromolecular_Interacting_Partner_1_General_References:
10800688; 12975309; 9888557; 11165019; 12697717

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
7549

# Macromolecular_Interacting_Partner_2_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
INS

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
INS

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11p15.5

# Macromolecular_Interacting_Partner_2_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_2_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_2_References:
1874169; 9861330

End of HMDB00031

Beginning of HMDB00032
# Accession_No:
HMDB00032

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-09-26 12:54:18

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
7-Dehydrocholesterol

# Description:
7-Dehydrocholesterol is a zoosterol (a sterol produced by animals rather than plants).  It is a provitamin-D. The presence of this compound in skin enables humans to manufacture vitamin D3 from ultra-violet rays in the sun light, via an intermediate isomer provitamin D3. It is also found in breast milk.

# Synonyms:
(-)-7-dehydrocholesterol; (3b)-Cholesta-5,7-dien-3-ol; (3beta)-Cholesta-5,7-dien-3-ol; 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol; 17-(1,5-dimethylhexyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 5,7-Cholestadien-3-beta-ol; 5,7-Cholestandien-3-ol; 5,7-Cholestandien-3beta-ol; 7,8-Didehydrocholesterol; 7,8-dehydro-cholesterol; 7-Dehydrocholesterin; 7-Dehydrocholesterol; 7-dehydro-cholesterol; 7DHC; Cholesta-5,7-dien-3-beta-ol; Cholesta-5,7-dien-3-ol; Cholesta-5,7-dien-3beta-ol; Dehydrocholesterin; Dehydrocholesterol; Provitamin D3; cholesta-5,7-dien-3 beta -ol; cholesta-5,7-dien-3b-ol; delta5,7-Cholestadien-3beta-ol; delta5,7-Cholesterol; delta7-Cholesterol; provitamin-D3

# Chemical_IUPAC_Name:
10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol

# Chemical_Formula:
C27H44O

# Chemical_Structure:
tbl_chemical:::HMDB00032_ZOOM.png:::119283142813985097

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00032_THUMB.png:::119283142580378387

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sterols

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
secondary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
384.33920

# Molecular_Weight_Avg:
384.63766

# Smiles_String_isomeric:
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

# Smiles_String_canonical:
CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C

# KEGG_Compound_ID:
C01164

# BioCyc_ID:
7-DEHYDRO-CHOLESTEROL

# PubChem_CID:
439423

# PubChem_SID:
3132652; 8144019; 4391; 12157001; 7850692; 10298334

# OMIM_ID:
223370; 270400

# Metagene_ID:
SMITH-LEMLI-OPITZ SYNDROME: 337

# BiGG_ID:
36958

# Wikipedia_ID:
7-Dehydrocholesterol

# METLIN_ID:
5101

# Ref_ID:
11710930; 12887150; 9290088; 10946022; 11590227; 9266395; 10069708; 11141372; 16451140; 2277111

# ChEBI_ID:
17759

# CAS_Registry_Number:
434-16-2

# InChI:
InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1951),  73  4496.

# Melting_Point:
150.5 oC

# Melting_Point_predicted:
124.9 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
1.08e-07 mg/mL [MEYLAN,WM et al. (1996)]; 1.48e-04 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
7.30 [Predicted by ALOGPS]; 7.2 [Predicted by PubChem via XLOGP]; 8.65 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::7-Dehydrocholesterol.pdf:::113256219138653277

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::7-Dehydrocholesterol.mol:::1132723802437137144

# SDF_File_[Text]:
tbl_chemical:::HMDB00032.sdf:::119283141907277821

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00032.pdb:::119283142406874161

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:


# H_NMR_FIDS_Spectra_Sykes:


# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80.png:::114828332386044165

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80.zip:::1148283323884359

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_07_IS_2DHSQC_80_Assigned.png:::116198757027244469

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7-Dehydrocholesterol.gif:::1132732100562804871

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00032_peaks.txt:::1156309498659645949

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7-Dehydrocholesterol_C.gif:::1132737661823934196

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00032_peaks.txt:::1156310690459304260

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00032L.png:::117555261855225736; Medium Energy:tbl_ms:::HMDB00032M.png:::117555266965166177; High Energy:tbl_ms:::HMDB00032H.png:::117555270849492203

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adrenal Gland; Brain; Epidermis; Fetus; Fibroblasts; Liver; Skin; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Urine	0.029 (0.0068-0.051)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	16451140
Blood	0.005 +/- 0.0022	uM	Adult:>18_yrs_old	Both	Normal	11590227
Cerebrospinal_Fluid(CSF)	0 - 0.02	umol/L	Adult:>18_yrs_old	Both	Normal	10946022


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	0.3 +/- 0.2 (0.1 - 0.6)	umol/L	Infant:0-1_yr_old	Both	Smith-Lemli-Opitz syndrome	9266395


# Associated_Disorders:
RSH Syndrome; Smith-Lemli-Opitz syndrome

# Pathway_Names:
Biosynthesis of steroids

# Pathway_Images:
Not Available

# KEGG_Images:
map00100

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5819

# Metabolic_Enzyme_1_Name:
7-dehydrocholesterol reductase

# Metabolic_Enzyme_1_Synonyms:
7-DHC reductase; Sterol Delta(7-reductase; Putative sterol reductase SR-2

# Metabolic_Enzyme_1_Gene_Name:
DHCR7

# Metabolic_Enzyme_1_Protein_Sequence:
>7dehydrocholesterol reductase
MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF

# Metabolic_Enzyme_1_Number_of_Residues:
475

# Metabolic_Enzyme_1_Molecular_Weight:
54490

# Metabolic_Enzyme_1_Theoretical_pI:
8.82

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)

# Metabolic_Enzyme_1_Pathway:
map00100  Biosynthesis of steroids

# Metabolic_Enzyme_1_Reaction:
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01222:ERG4_ERG24

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
40-60
154-174
177-197
266-286
306-326
331-351
420-440

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.21

# Metabolic_Enzyme_1_GenBank_ID_Protein:
4191398

# Metabolic_Enzyme_1_SwissProt_ID:
DHCR7_HUMAN (Q9UBM7)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
DHCR7

# Metabolic_Enzyme_1_Geneatlas_id:
DHCR7

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2860

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1428 bp
ATGGCTGCAAAATCGCAACCCAACATTCCCAAAGCCAAGAGTCTAGATGGCGTCACCAAT
GACAGAACCGCATCTCAAGGGCAGTGGGGCCGTGCCTGGGAGGTGGACTGGTTTTCACTG
GCGAGCGTCATCTTCCTACTGCTGTTCGCCCCCTTCATCGTCTACTACTTCATCATGGCT
TGTGACCAATACAGCTGCGCCCTGACCGGCCCTGTGGTGGACATCGTCACCGGACATGCT
CGGCTCTCGGACATCTGGGCCAAGACTCCACCTATAACGAGGAAAGCCGCCCAGCTCTAT
ACCTTGTGGGTCACCTTCCAGGTGCTTCTGTACACGTCTCTCCCTGACTTCTGCCATAAG
TTTCTACCCGGCTACGTAGGAGGCATCCAGGAGGGGGCCGTGACTCCTGCAGGGGTTGTG
AACAAGTATCAGATCAACGGCCTGCAAGCCTGGCTCCTCACGCACCTGCTCTGGTTTGCA
AACGCTCATCTCCTGTCCTGGTTCTCGCCCACCATCATCTTCGACAACTGGATCCCACTG
CTGTGGTGCGCCAACATCCTTGGCTATGCCGTCTCCACCTTCGCCATGGTCAAGGGCTAC
TTCTTCCCCACCAGCGCCAGAGACTGCAAATTCACAGGCAATTTCTTTTACAACTACATG
ATGGGCATCGAGTTTAACCCTCGGATCGGGAAGTGGTTTGACTTCAAGCTGTTCTTCAAT
GGGCGCCCCGGGATCGTCGCCTGGACCCTCATCAACCTGTCCTTCGCAGCGAAGCAGCGG
GAGCTCCACAGCCATGTGACCAATGCCATGGTCCTGGTCAACGTCCTGCAGGCCATCTAC
GTGATTGACTTCTTCTGGAACGAAACCTGGTACCTGAAGACCATTGACATCTGCCATGAC
CACTTCGGGTGGTACCTGGGCTGGGGCGACTGTGTCTGGCTGCCTTATCTTTACACGCTG
CAGGGTCTGTACTTGGTGTACCACCCCGTGCAGCTGTCCACCCCGCACGCCGTGGGCGTC
CTGCTGCTGGGCCTGGTGGGCTACTACATCTTCCGGGTGGCCAACCACCAGAAGGACCTG
TTCCGCCGCACGGATGGGCGCTGCCTCATCTGGGGCAGGAAGCCCAAGGTCATCGAGTGC
TCCTACACATCCGCCGACGGGCAGAGGCACCACAGCAAGCTGCTGGTGTCGGGCTTCTGG
GGCGTGGCCCGCCACTTCAACTACGTCGGCGACCTGATGGGCAGCCTGGCCTACTGCCTG
GCCTGTGGCGGTGGCCACCTGCTGCCCTACTTCTACATCATCTACATGGCCATCCTGCTG
ACCCACCGCTGCCTCCGGGACGAGCACCGCTGCGCCAGCAAGTACGGCCGGGACTGGGAG
CGCTACACCGCCGCAGTGCCTTACCGCCTGCTGCCTGGAATCTTCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF096305

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_1_Locus:
11q13.2-q13.5

# Metabolic_Enzyme_1_SNPs:
rs760242; rs12577137; rs1790334; rs1044482; rs949177; rs760241; rs4316537; rs909217; rs1790345; rs1044535; rs3750997; rs12573951; rs10450661; rs7690; rs1790324; rs736894; rs1790328; rs1790330; rs1792268; rs17161531; rs1790327; rs1790329; rs1630498; rs949176; rs1792264; rs2852853; rs11603330; rs2851693; rs11606033; rs1790325; rs1792265; rs1790326; rs10898144; rs12422045; rs1792270; rs1790348; rs7122671; rs1790346; rs4944949; rs28364617; rs7928249; rs10450662; rs1790347; rs4944946; rs11555217; rs1127869; rs28939698; rs12800; rs35946774; rs11233662; rs34258235; rs5792560; rs1802126; rs34995793; rs12407; rs7950991; rs11233706; rs34541828; rs34240558; rs1802125; rs11555218; rs35616583; rs12271811; rs1802378; rs34463022; rs35826756; rs2852855; rs28364772; rs12281087; rs34405099; rs2851692; rs12294879; rs2852857; rs2852850; rs12283656; rs12285189; rs760238; rs2852849; rs2852858; rs760240; rs1790331; rs1792223; rs1792267; rs2852851; rs2852854; rs5792559; rs34177783; rs11233679; rs2852856; rs760239; rs1790332; rs2851691; rs28364773; rs2852852; rs35589965; rs11233713; rs35649052; rs28364616; rs11546508; rs34809983; rs7944310; rs12804192; rs11366361; rs12270619; rs12272475; rs12280295; rs12285168; rs12285333; rs12419279; rs12419334; rs12785878; rs12797951; rs1623080; rs1629055; rs1790349; rs1790351; rs1790352; rs1790353; rs1790373; rs1792271; rs1792272; rs1792273; rs1792275; rs1792276; rs1792277; rs1792278; rs1792279; rs1792316; rs2002063; rs2002064; rs3184354; rs4944955; rs4944956; rs4944957; rs4944958; rs4944959; rs7944926

# Metabolic_Enzyme_1_General_References:
9683613; 9465114; 9878250; 9634533; 9653161; 10677299; 10995508; 11175299; 12949967

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5367

# Metabolic_Enzyme_2_Name:
Lathosterol oxidase

# Metabolic_Enzyme_2_Synonyms:
Lathosterol 5-desaturase; Delta(7-sterol 5-desaturase; C-5 sterol desaturase; Sterol-C5- desaturase

# Metabolic_Enzyme_2_Gene_Name:
SC5DL

# Metabolic_Enzyme_2_Protein_Sequence:
>Lathosterol oxidase
MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE

# Metabolic_Enzyme_2_Number_of_Residues:
299

# Metabolic_Enzyme_2_Molecular_Weight:
35301

# Metabolic_Enzyme_2_Theoretical_pI:
8.24

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01598:Sterol_desat

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
32-52
79-99
117-137
186-206

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.21.6

# Metabolic_Enzyme_2_GenBank_ID_Protein:
1906796

# Metabolic_Enzyme_2_SwissProt_ID:
SC5D_HUMAN (O75845)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
SC5DL

# Metabolic_Enzyme_2_Geneatlas_id:
SC5DL

# Metabolic_Enzyme_2_hgnc_id:
HGNC:10547

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein (Probable)

# Metabolic_Enzyme_2_Gene_Sequence:
>711 bp
ATGGATCTTGTACTCCGTGTTGCAGATTACTATTTTTTTACACCATACGTGTATCCAGCC
ACATGGCCAGAAGATGACATCTTCCGACAAGCTATTAGTCTTCTGATTGTAACAAATGTT
GGTGCTTACATCCTTTATTTCTTCTGTGCAACACTGAGCTATTATTTTGTCTTCGATCAT
GCATTAATGAAACATCCACAATTTTTAAAGAATCAAGTCCGTCGAGAGATTAAGTTTACT
GTCCAGGCATTGCCATGGATAAGTATTCTTACTGTTGCACTGTTCTTGCTGGAGATAAGA
GGTTACAGCAAATTACATGATGACCTAGGAGAGTTTCCATATGGATTGTTTGAACTTGTC
GTTAGTATAATATCTTTCCTCTTTTTCACTGACATGTTCATCTACTGGATTCACAGAGGC
CTTCATCATAGACTGGTATATAAGCGCCTACATAAACCTCACCATATTTGGAAGATTCCT
ACTCCATTTGCAAGTCATGCTTTTCACCCTATTGATGGCTTTCTTCAGAGTCTACCTTAC
CATATATACCCTTTTATCTTTCCATTACACAAGGTGGTTTATTTAAGTCTGTACATCTTG
GTTAATATCTGGACAATTTCCATTCATGACGGTGATTTTCGTGTAAGAATGAAAAATTAT
TCAATGGAGAGTTTACAAAGACTGAATAGATTATTGCCCAGTTATTCTTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
D85181

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_2_Locus:
11q23.3

# Metabolic_Enzyme_2_SNPs:
rs1061332; rs11218245; rs17125142; rs7112214; rs11823304; rs12362657; rs7930204; rs2060008; rs7942396; rs2060007; rs12786590; rs35536707; rs11551925; rs17854634; rs1801852; rs34614904; rs35233317; rs11551924; rs34831010; rs35940360; rs35781210; rs35783080; rs11218244; rs10712296; rs35440276; rs7943648; rs35224843; rs11415316; rs12418379; rs12421209; rs10750184; rs10892720; rs10892721; rs11218247; rs11218248; rs12223482; rs12223498; rs12275106; rs12284608; rs12287112; rs12292444; rs12421079; rs12421277; rs1560409; rs2115923; rs2115925; rs2163281; rs3741013; rs6589870; rs6589872; rs6589873; rs7103341; rs7115581; rs7115602; rs7125671; rs7128047; rs7128664; rs727422; rs751417; rs7924558; rs7924930; rs7928868; rs7929848; rs7939864; rs891435; rs891441

# Metabolic_Enzyme_2_General_References:
8976377; 10344195; 10786622; 12189593; 12812989

# Metabolic_Enzyme_2_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
6198

# Macromolecular_Interacting_Partner_1_Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase

# Macromolecular_Interacting_Partner_1_Synonyms:
HMG-CoA reductase

# Macromolecular_Interacting_Partner_1_Gene_Name:
HMGCR

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>3hydroxy3methylglutarylcoenzyme A reductase
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
888

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
97477

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.72

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  organelle membrane
Component:  endoplasmic reticulum membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_1_Specific_Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis

# Macromolecular_Interacting_Partner_1_Pathway:
map00100  Biosynthesis of steroids

# Macromolecular_Interacting_Partner_1_Reaction:
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00368:HMG-CoA_red

# Macromolecular_Interacting_Partner_1_Signals:
1-23

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.1.1.34

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
306865

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
HMDH_HUMAN (P04035)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
HMGCR

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
HMGCR

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5006

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Peroxisome; peroxisomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>2667 bp
ATGTTGTCAAGACTTTTTCGAATGCATGGCCTCTTTGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACACTGACCATCTGCATGATGTCCATGAACATGTTTACTGGTAAC
AATAAGATCTGTGGTTGGAATTATGAATGTCCAAAGTTTGAAGAGGATGTTTTGAGCAGT
GACATTATAATTCTGACAATAACACGATGCATAGCCATCCTGTATATTTACTTCCAGTTC
CAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGCCTTTTCACAATT
TTCTCAAGTTTTGTATTCAGTACAGTTGTCATTCACTTCTTAGACAAAGAATTGACAGGC
TTGAATGAAGCTTTGCCCTTTTTCCTACTTTTGATTGACCTTTCCAGAGCAAGCACATTA
GCAAAGTTTGCCCTCAGTTCCAACTCACAGGATGAAGTAAGGGAAAATATTGCTCGTGGA
ATGGCAATTTTAGGTCCTACGTTTACCCTCGATGCTCTTGTTGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTACGTCAGCTTGAAATTATGTGCTGCTTTGGCTGCATGTCA
GTTCTTGCCAACTACTTCGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTATTA
GAGCTTTCTCGGGAAAGCCGCGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCCCGA
GTTTTAGAAGAAGAAGAAAATAAGCCGAATCCTGTAACTCAGAGGGTCAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCATGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGTACAGCAGATACTTCTAAGGTTTCATTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAACAGAGACAGAATCTACACTCTCATTAAAAAACCCTATCACATCTCCTGTAGTGACA
CAAAAGAAAGTCCCAGACAATTGTTGTAGACGTGAACCTATGCTGGTCAGAAATAACCAG
AAATGTGATTCAGTAGAGGAAGAGACAGGGATAAACCGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTAGTGGCTGAAACAGATACCCCAAACAGAGCTACATTTGTGGTTGGTAACTCC
TCCTTACTCGATACTTCATCAGTACTGGTGACACAGGAACCTGAAATTGAACTTCCCAGG
GAACCTCGGCCTAATGAAGAATGTCTACAGATACTTGGGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTAGTCAATGCTAAGCATATCCCAGCCTACAAG
TTGGAAACTCTGATGGAAACTCATGAGCGTGGTGTATCTATTCGCCGACAGTTACTTTCC
AAGAAGCTTTCAGAACCTTCTTCTCTCCAGTACCTACCTTACAGGGATTATAATTACTCC
TTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCCCTTTGCTTAGATGAAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGT
TGTCTTGTGGCCAGCACCAATAGAGGCTGCAGAGCAATAGGTCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGATGGGATGACTCGTGGCCCAGTTGTGCGTCTTCCACGTGCTTGT
GACTCTGCAGAAGTGAAAGCCTGGCTCGAAACATCTGAAGGGTTCGCAGTGATAAAGGAG
GCATTTGACAGCACTAGCAGATTTGCACGTCTACAGAAACTTCATACAAGTATAGCTGGA
CGCAACCTTTATATCCGTTTCCAGTCCAGGTCAGGGGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTTTCAAAACTTCACGAGTATTTCCCTGAAATGCAGATT
CTAGCCGTTAGTGGTAACTATTGTACTGACAAGAAACCTGCTGCTATAAATTGGATAGAG
GGAAGAGGAAAATCTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACCACAGAGGCTATGATTGAGGTCAACATTAACAAGAATTTAGTGGGCTCT
GCCATGGCTGGGAGCATAGGAGGCTACAACGCCCATGCAGCAAACATTGTCACCGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCAAACTGTATTACTTTA
ATGGAAGCAAGTGGTCCCACAAATGAAGATTTATATATCAGCTGCACCATGCCATCTATA
GAGATAGGAACGGTGGGTGGTGGGACCAACCTACTACCTCAGCAAGCCTGTTTGCAGATG
CTAGGTGTTCAAGGAGCATGCAAAGATAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGA
ATTGTGTGTGGGACCGTAATGGCTGGGGAATTGTCACTTATGGCAGCATTGGCAGCAGGA
CATCTTGTCAAAAGTCACATGATTCACAACAGGTCGAAGATCAATTTACAAGACCTCCAA
GGAGCTTGCACCAAGAAGACAGCCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M11058

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_1_Locus:
5q13.3-q14

# Macromolecular_Interacting_Partner_1_SNPs:
rs5908; rs10038095; rs12916; rs10045497; rs5909; rs17883498; rs17244932; rs17238554; rs17238379; rs17244771; rs17238372; rs17244764; rs17238393; rs17244757; rs17244743; rs17244778; rs6805; rs10474435; rs2241402; rs2878419; rs3846662; rs3846661; rs10942735; rs3846663; rs6453131; rs6882842; rs17244855; rs12654264; rs7717396; rs17244841; rs17244806; rs17238596; rs17238540; rs17244862; rs10473972; rs10474434; rs17244890; rs11742194; rs10515198; rs17238477; rs17244848; rs17244883; rs17238449; rs17244834; rs2303152; rs17244813; rs17238484; rs3064877; rs11957984; rs10053643; rs17238435; rs2303151; rs17238456; rs17238603; rs35767444; rs17238575; rs17238589; rs17244897; rs17244827; rs10063134; rs35635349; rs3843482; rs17238519; rs17238498; rs17244792; rs17244799; rs17244960; rs17244785; rs17238442; rs17244876; rs4629571; rs3761739; rs17244953; rs17238337; rs17238330; rs17244708; rs3761738; rs3761740; rs17244946; rs17244715; rs34652146; rs34334938; rs35436905; rs35561739; rs36010179; rs1044453; rs11402730; rs35855355; rs34198674; rs11453557; rs12657545; rs35306582; rs10683134; rs11379632; rs17648121; rs33988510; rs11443896; rs10590407; rs2898551; rs3064191; rs35744174; rs35152895; rs35491024; rs33926107; rs13436857; rs11743717; rs11749783; rs11957619; rs16872521; rs16872523; rs3180743; rs35176659; rs3733907; rs3761741; rs3843480; rs3843481; rs3931914; rs4703670; rs4704209; rs7703051

# Macromolecular_Interacting_Partner_1_General_References:
2991281; 10698924; 10391209

# Macromolecular_Interacting_Partner_1_References:
7557099; 9548596

End of HMDB00032

Beginning of HMDB00033
# Accession_No:
HMDB00033

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-19 15:13:42

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Carnosine

# Description:
Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies. (PMID 16804013) Carnosine is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the "hyperactivity" seen in autistic subjects at higher doses.  Carnosine also exhibits some anti-oxidant effects.

# Synonyms:
Beta-Alanyl-L-histidine; Carnosine; Ignotine; Karnozin; Karnozzn; L-Carnosine; N-(3-Aminopropanoyl)histidine; N-(b-Alanyl)-L-histidine; N-b-alanyl-L-Histidine; N-beta-alanyl-L-Histidine; b-Alanyl-L-histidine; b-Alanylhistidine; beta-Alanylhistidine

# Chemical_IUPAC_Name:
2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid

# Chemical_Formula:
C9H14N4O3

# Chemical_Structure:
tbl_chemical:::HMDB00033_ZOOM.png:::119283143906862773

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00033_THUMB.png:::119283143702551120

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; secondary carboxylic acid amide; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of beta-Alanine metabolism; Component of Histidine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
226.10658

# Molecular_Weight_Avg:
226.23245

# Smiles_String_isomeric:
C[C@H](N)C(=O)C([C@H](N)C(O)=O)C1=CNC=N1

# Smiles_String_canonical:
CC(N)C(=O)C(C(N)C(O)=O)C1=CNC=N1

# KEGG_Compound_ID:
C00386

# BioCyc_ID:
CARNOSINE

# PubChem_CID:
439224

# PubChem_SID:
11366634; 3676; 11494992; 11488270; 10298255; 11537748; 11377358; 11491027; 11369196; 11361828; 11113307; 8143363; 11487230; 3138777; 11364072; 11493487; 11484264; 11375363; 11341645; 11372223

# OMIM_ID:
212200; 236130; 237400

# Metagene_ID:
GABA TRANSAMINASE DEFICIENCY: 32; CARNOSINURIA: 82

# BiGG_ID:
1800369

# Wikipedia_ID:
Carnosine

# METLIN_ID:
38

# Ref_ID:
15941308; 16181134; 9928418; 16162015; 11707898; 2674258; 15878720; 11976203; 1735411; 11470131; 12139778; 11911459; 9029640; 16287364; 15853927; 8689392

# ChEBI_ID:
15727

# CAS_Registry_Number:
305-84-0

# InChI:
InChI=1/C9H14N4O3/c1-4(10)8(14)6(7(11)9(15)16)5-2-12-3-13-5/h2-4,6-7H,10-11H2,1H3,(H,12,13)(H,15,16)/t4-,6?,7-/m0/s1

# Synthesis_Reference:
Synthesis of carnosine by trimethylsilyl protection.     Vezenkov, L.; Yanachkov, O.    Dep. Org. Chem.,  Higher Inst. Chem. Technol.,  Sofia,  Bulg.    Dokladi na Bulgarskata Akademiya na Naukite  (1991),  44(8),  53-6

# Melting_Point:
253-256 oC

# Melting_Point_predicted:
109.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
384 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
82.1 mg/mL [MEYLAN,WM et al. (1996)]; 32.1 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.72 [Predicted by ALOGPS]; -4.1 [Predicted by PubChem via XLOGP]; -1.81 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Carnosine.pdf:::1132562191646531638

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Carnosine.mol:::1132723802515305277

# SDF_File_[Text]:
tbl_chemical:::HMDB00033.sdf:::119283143249152549

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00033.pdb:::119283143529157339

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_presat_expanded_2.gif:::114460751555437021

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_presat.zip:::1175124305325404209

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::050110_P00_02_IS_1DP_Assigned.png:::116414673131324051

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76.jpg:::114168392349448013

# C_NMR_FIDS_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76.zip:::114168392318065290

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::050110_P00_02_IS_1DC_76_Assigned.jpg:::116000060034661306

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254.jpg:::114608659377263489

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254.zip:::114608659379341224

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050110_P00_02_IS_2DHSQC_254_Assigned.jpg:::114608659406624555

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Carnosine.gif:::115324906652996401

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00033_peaks.txt:::1156309499758261496

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Carnosine_C.gif:::115324906653888774

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00033_peaks.txt:::1156310691468422149

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00033L.png:::117555261937624170; Medium Energy:tbl_ms:::HMDB00033M.png:::117555267061464108; High Energy:tbl_ms:::HMDB00033H.png:::11755527091703986

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000246.png:::116907445173427345

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000246.txt:::116907445173416905

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000246.png:::116890832812577418

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000246.txt:::11689083283432036

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Brain; Fibroblasts; Intestine; Kidney; Liver; Muscle; Neurons; Skeletal Muscle

# deuterated:
No

# Biofluid_Location:
Blood; Urine

# Concentration_[Normal]:
Urine	<6.579	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Urine	0.014-0.032	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	Doctor's Data
Urine	1.1+/-0.5	umol/mmol_creatinine	N/A	Both	Normal	9029640
Blood	3.1 +/- 7.5	umol/L	Infant:0-1_yr_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 80-97. Edited by Cornelius Lentner. ; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. ; Basle, Switzerland c1981-1992. 
Blood	81.5 (0.0-163.0)	uM	Adult:>18_yrs_old	Both	Normal	15941308


# Concentration_[Abnormal]:
Urine	56.56-113.1	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Carnosinuria	2674258


# Associated_Disorders:
Carnosinuria; Chronic Renal Failure; Neuromuscular Diseases

# Pathway_Names:
Beta-Alanine metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00410

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5713

# Metabolic_Enzyme_1_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_1_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_1_Gene_Name:
CNDP1

# Metabolic_Enzyme_1_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_1_Number_of_Residues:
507

# Metabolic_Enzyme_1_Molecular_Weight:
56693

# Metabolic_Enzyme_1_Theoretical_pI:
4.95

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_1_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_1_Signals:
1-26

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_1_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_1_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CNDP1

# Metabolic_Enzyme_1_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_1_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_1_Locus:
18q22.3

# Metabolic_Enzyme_1_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_1_General_References:
12975309

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5712

# Metabolic_Enzyme_2_Name:
Ceruloplasmin precursor

# Metabolic_Enzyme_2_Synonyms:
Ferroxidase

# Metabolic_Enzyme_2_Gene_Name:
CP

# Metabolic_Enzyme_2_Protein_Sequence:
>Ceruloplasmin precursor
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP
DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH
SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH
SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC
SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH
GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS
SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY
KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV
RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY
SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF
TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF
SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR
QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK
KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ
TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC
RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA
INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP
GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG

# Metabolic_Enzyme_2_Number_of_Residues:
1065

# Metabolic_Enzyme_2_Molecular_Weight:
122206

# Metabolic_Enzyme_2_Theoretical_pI:
5.50

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_2_Specific_Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It is involved in iron transport across the cell membrane

# Metabolic_Enzyme_2_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00394:Cu-oxidase;
PF07731:Cu-oxidase_2;
PF07732:Cu-oxidase_3

# Metabolic_Enzyme_2_Signals:
1-19

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.16.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
180256

# Metabolic_Enzyme_2_SwissProt_ID:
CERU_HUMAN (P00450)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CP

# Metabolic_Enzyme_2_Geneatlas_id:
CP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2295

# Metabolic_Enzyme_2_PDB_ID:
1KCW

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_2_Gene_Sequence:
>3198 bp
ATGAAGATTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAA
GAAAAGCATTATTACATTGGAATTATTGAAACGACTTGGGATTATGCCTCTGACCATGGG
GAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCA
GATAGAATTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTT
AGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTTTAGGCCCTATTATCAAAGCTGAA
ACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCAT
TCACATGGAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACA
GATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAGAGCAGTATACATACATGTTGCTT
GCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCAT
TCCCACATTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGT
AAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATATTGACCGAGAATTTGTGGTGATG
TTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGC
TCAGAACCAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTAT
TCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGACTCTCCATGTGTGCTGAAGACAGA
GTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCAC
GGGCAAGCACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACC
CTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAGAATGGATGCTCAGCTGTCAGAAT
CTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCT
TCATCAAAGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAA
ATCATCTGGAACTATGCTCCCTCTGGTATAGACATCTTCACTAAAGAAAACTTAACAGCA
CCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTAT
AAAAAGCTGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGC
CCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCATTTGGGCAGAGGTGGGAGACACC
ATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTG
AGATTCAATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGA
AGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAGAAACATTCACCTATGAATGGACT
GTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTAT
TCTGCTGTGGATCCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGC
AAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAGATGTAGACAAGGAATTCTATTTG
TTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTT
ACAACTGCACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATG
CACTCCATGAATGGATTCATGTATGGGAATCAGCCGGGTCTCACTATGTGCAAAGGAGAT
TCGGTCGTGTGGTACTTATTCAGCGCCGGAAATGAGGCCGATGTACATGGAATATACTTT
TCAGGAAACACATATCTGTGGAGAGGAGAACGGAGAGACACAGCAAACCTCTTCCCTCAA
ACAAGTCTTACGCTCCACATGTGGCCTGACACAGAGGGGACTTTTAATGTTGAATGCCTT
ACAACTGATCATTACACAGGCGGCATGAAGCAAAAATATACTGTGAACCAATGCAGGCGG
CAGTCTGAGGATTCCACCTTCTACCTGGGAGAGAGGACATACTATATCGCAGCAGTGGAG
GTGGAATGGGATTATTCCCCACAAAGGGAGTGGGAAAAGGAGCTGCATCATTTACAAGAG
CAGAATGTTTCAAATGCATTTTTAGATAAGGGAGAGTTTTACATAGGCTCAAAGTACAAG
AAAGTTGTGTATCGGCAGTATACTGATAGCACATTCCGTGTTCCAGTGGAGAGAAAAGCT
GAAGAAGAACATCTGGGAATTCTAGGTCCACAACTTCATGCAGATGTTGGAGACAAAGTC
AAAATTATCTTTAAAAACATGGCCACAAGGCCCTACTCAATACATGCCCATGGGGTACAA
ACAGAGAGTTCTACAGTTACTCCAACATTACCAGGTGAAACTCTCACTTACGTATGGAAA
ATCCCAGAAAGATCTGGAGCTGGAACAGAGGATTCTGCTTGTATTCCATGGGCTTATTAT
TCAACTGTGGATCAAGTTAAGGACCTCTACAGTGGATTAATTGGCCCCCTGATTGTTTGT
CGAAGACCTTACTTGAAAGTATTCAATCCCAGAAGGAAGCTGGAATTTGCCCTTCTGTTT
CTAGTTTTTGATGAGAATGAATCTTGGTACTTAGATGACAACATCAAAACATACTCTGAT
CACCCCGAGAAAGTAAACAAAGATGATGAGGAATTCATAGAAAGCAATAAAATGCATGCT
ATTAATGGAAGAATGTTTGGAAACCTACAAGGCCTCACAATGCACGTGGGAGATGAAGTC
AACTGGTATCTGATGGGAATGGGCAATGAAATAGACTTACACACTGTACATTTTCACGGC
CATAGCTTCCAATACAAGCACAGGGGAGTTTATAGTTCTGATGTCTTTGACATTTTCCCT
GGAACATACCAAACCCTAGAAATGTTTCCAAGAACACCTGGAATTTGGTTACTCCACTGC
CATGTGACCGACCACATTCATGCTGGAATGGAAACCACTTACACCGTTCTACAAAATGAA
GACACCAAATCTGGCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M13699

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3q23-q25

# Metabolic_Enzyme_2_SNPs:
rs34624984; rs701753; rs1053709; rs34237139; rs34394958; rs35438054; rs9834971; rs1523514; rs6799507; rs772908; rs12496866; rs6768350; rs1523513; rs4974389; rs11917114; rs701755; rs3107836; rs34004251; rs16861576; rs11919626; rs16861598; rs1879169; rs16861602; rs16861633; rs6440590; rs11922514; rs16861593; rs773050; rs16861577; rs35284835; rs16861582; rs34171195; rs3736282; rs16861590; rs16861588; rs7632958; rs16861634; rs11714000; rs11924891; rs17847023; rs34951015; rs10935743; rs11921705; rs3816893; rs11709714; rs34865491; rs16861579; rs17787768; rs7632964; rs16861637; rs11924961; rs16861596; rs701751; rs3765125; rs701754; rs10935742; rs7652826; rs9853335; rs6792209; rs34861155; rs11915834; rs1523515; rs9841442; rs35593818; rs35610536; rs34481162; rs34300334; rs35903829; rs2681084; rs13072552; rs34175628; rs13092519; rs13095262; rs34626625; rs35191080; rs36074020; rs696994; rs772904; rs34079352; rs36021368; rs35229573; rs35966950; rs34013572; rs36098024; rs35773127; rs35386382; rs35876747; rs34649438; rs36106034; rs34443048; rs34656703; rs35716500; rs35272481; rs34067682; rs34042451; rs35899708; rs35378125; rs34842353; rs35653745; rs35123935; rs1908053; rs35165738; rs34930306; rs34650204; rs34052330; rs34617132; rs798842; rs35727759; rs35062355; rs34654392; rs1879168; rs35767691; rs34770768; rs16861639; rs13075891; rs34010341; rs34535555; rs34011114; rs35529745; rs34335440; rs13084448; rs34335607; rs11710581; rs34867923; rs35541542; rs34504513; rs34454179; rs36103494; rs36099841; rs35244189; rs34586382; rs16861636; rs13075921; rs34823342; rs13080467; rs35216818; rs34753475; rs34296476; rs772907; rs35334247; rs11288866; rs35516209; rs34907627; rs34670346; rs34091282; rs7634054; rs34645589; rs34516709; rs34312834; rs35848147; rs35198307; rs35976863; rs35090057; rs10935744; rs35364670; rs34049286; rs7632719; rs34155161; rs35904683; rs36027953; rs35718216; rs35503313; rs34142100; rs35358026; rs809554; rs34414552; rs34751274; rs35149808; rs35048481; rs701748; rs3755644; rs696993; rs701749; rs35682120; rs17838832; rs36024032; rs35691438; rs17838831; rs35622518; rs35474921; rs17838834; rs34851340; rs17838833; rs17847018; rs11553309; rs2681095; rs35331711; rs2640038; rs34386552; rs17847026; rs34987997; rs17847022; rs17847025; rs13314294; rs1063899; rs17847016; rs11553308; rs35142039; rs35334652; rs9833860; rs13080302; rs10540828; rs34817492; rs2681098; rs35103260; rs11920882; rs12107157; rs35879864; rs798841; rs34855818; rs35885078; rs17847019; rs28722677; rs701750; rs34399626; rs35132881; rs3103861; rs35551942; rs35238123; rs2933882; rs2640037; rs2681094; rs28657647; rs34861029; rs2640042; rs7623387; rs28361508; rs35019965; rs36103142; rs811635; rs6767930; rs10718513; rs13062843; rs9833659; rs34251410; rs9653952; rs809553; rs35465173; rs11926259; rs2681099; rs35766301; rs34321384; rs35942827; rs34375295; rs10663585; rs34372049; rs34929084; rs2681083; rs34355891; rs35721007; rs4974392; rs35900668; rs41267873; rs34841236; rs34145911; rs11451281; rs34568785; rs34757057; rs34750070; rs17847028; rs34113826; rs2640039; rs12487772; rs11380808; rs2933883; rs2933884; rs35193625; rs35236994; rs35752872; rs2681080; rs810089; rs35652604; rs34875136; rs10573853; rs10631065; rs35048131; rs35288810; rs34437667; rs13091064; rs34556731; rs35102207; rs9821640; rs34700374; rs34230520; rs34241019; rs10576836; rs34686915; rs3736520; rs701757; rs2946680; rs34895769; rs35927352; rs2640044; rs35196125; rs34550573; rs35076221; rs772906; rs34343199; rs34696248; rs35850459; rs35090033; rs35204894; rs34636664; rs701752; rs13079008; rs34445333; rs35267205; rs34315195; rs34873592; rs9857073; rs35360246; rs2681100; rs34016079; rs35335199; rs2640041; rs35974775; rs34523231; rs34832681; rs2681097; rs13091078; rs2681086; rs34171193; rs35682875; rs10661618; rs2971562; rs34575419; rs810088; rs35387181; rs34239280; rs3070607; rs35855023; rs17847024; rs36107315; rs17847017; rs2640043; rs35913214; rs2681082; rs6777849; rs34003547; rs34938986; rs11374895; rs11309557; rs34618068; rs11347585; rs35972521; rs34587777; rs701756; rs2933885; rs2681093; rs35886571; rs2640040; rs35068918; rs13068416; rs34168096; rs28390156; rs34571365; rs28408096; rs36074830; rs13068197; rs35937468; rs35816853; rs35358355; rs11288867; rs812829; rs36036828; rs35296558; rs2681085; rs34510606; rs34053109; rs35633059; rs34334174; rs34109328; rs34110798; rs11708215; rs11720427; rs12494334; rs13066364; rs13095764; rs13096289; rs13098532; rs16846602; rs16861642; rs16861645; rs16861646; rs16861647; rs16861649; rs17195505; rs2177392; rs2681092; rs2681096; rs2681101; rs2981470; rs2981471; rs34060990; rs35196849; rs35355363; rs35371359; rs35555422; rs3732557; rs3755641; rs3755642; rs4681170; rs4681490; rs7623663; rs9877778

# Metabolic_Enzyme_2_General_References:
2873574; 7702601; 3755405; 3486416; 6582496; 6571985; 6940148; 6987229; 6987230; 2355023; 12055353

# Metabolic_Enzyme_2_References:
11911459; 12132593

# Metabolic_Enzyme_3_ID:
6878

# Metabolic_Enzyme_3_Name:
Catalase

# Metabolic_Enzyme_3_Synonyms:
Not Available

# Metabolic_Enzyme_3_Gene_Name:
CAT

# Metabolic_Enzyme_3_Protein_Sequence:
>Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

# Metabolic_Enzyme_3_Number_of_Residues:
527

# Metabolic_Enzyme_3_Molecular_Weight:
59757

# Metabolic_Enzyme_3_Theoretical_pI:
7.41

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
Function:  catalase activity
 ||
>>>
Process:  oxygen and reactive oxygen species metabolism
Process:  response to oxidative stress
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

# Metabolic_Enzyme_3_Pathway:
map00380  Tryptophan metabolism;
 map00680  Methane metabolism

# Metabolic_Enzyme_3_Reaction:
2 H2O2 = O2 + 2 H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00199:Catalase

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.11.1.6

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1228085

# Metabolic_Enzyme_3_SwissProt_ID:
CATA_HUMAN (P04040)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CAT

# Metabolic_Enzyme_3_Geneatlas_id:
CAT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:1516

# Metabolic_Enzyme_3_PDB_ID:
1F4J

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_3_Gene_Sequence:
>66 bp
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X04085

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p13

# Metabolic_Enzyme_3_SNPs:
rs17880442; rs11032709; rs769217; rs35677492; rs1049982; rs2234940; rs1050032; rs566979; rs769218; rs511895; rs524167; rs494024; rs1408035; rs560807; rs10488736; rs2284367; rs482322; rs7947841; rs480496; rs11032699; rs2300182; rs2284365; rs7103083; rs499406; rs3758730; rs4755372; rs508370; rs7933285; rs1000343; rs554576; rs2073059; rs11032701; rs17886008; rs4755373; rs484214; rs6484722; rs543701; rs17884666; rs2420389; rs551929; rs480575; rs10836244; rs2179625; rs7113917; rs2268063; rs533425; rs12272630; rs17881488; rs486256; rs17884576; rs2073058; rs11604331; rs17884491; rs7120960; rs1408034; rs524154; rs7109778; rs7101395; rs17881288; rs12269988; rs7126610; rs10836235; rs16925608; rs16925614; rs11824384; rs2284368; rs17883121; rs2420388; rs4756146; rs16925606; rs17884086; rs2284364; rs7930427; rs12803540; rs1408036; rs17268652; rs2284366; rs17881567; rs2300181; rs7928213; rs11032702; rs16925581; rs525938; rs11032700; rs17881921; rs17884095; rs17885743; rs17881476; rs17883793; rs11826620; rs12270780; rs35915891; rs2268064; rs17883592; rs17884725; rs17881482; rs17880673; rs2284369; rs17883544; rs11032703; rs12273124; rs17884248; rs35755143; rs7126640; rs2076556; rs4755374; rs1055981; rs17884335; rs17884518; rs17880274; rs17883699; rs4756148; rs17886200; rs475043; rs564250; rs769214; rs9282626; rs7943316; rs9282627; rs7104301; rs17883920; rs1001179; rs17881029; rs17886350; rs2266625; rs34455645; rs3180560; rs11546300; rs1050028; rs2266629; rs2266619; rs14527; rs2266628; rs35012776; rs34964953; rs34727149; rs3831770; rs17886810; rs35927227; rs7121850; rs17885881; rs17882812; rs17885837; rs17880607; rs17882039; rs17881916; rs17880549; rs34138762; rs28586982; rs34503767; rs36074933; rs515130; rs35099202; rs35849009; rs17881846; rs17887048; rs17881224; rs17884421; rs34840731; rs17881231; rs35340649; rs35292563; rs17884242; rs12286702; rs35034960; rs28733253; rs17887248; rs35791482; rs35703808; rs35648206; rs34808995; rs35386961; rs34420404; rs856714; rs17883483; rs17884804; rs17883367; rs17883534; rs17880160; rs17886672; rs34281397; rs34790990; rs2982523; rs35122257; rs2284370; rs12798927; rs35781217; rs11032707; rs17886592; rs4483566; rs34890123; rs4272763; rs12789374; rs17881734; rs35330036; rs17883434; rs35081167; rs17886155; rs17886248; rs34840787; rs34890990; rs17881192; rs17881586; rs34267165; rs12786539; rs35834969; rs3818354; rs17884443; rs36224415; rs36224416; rs36224102; rs10312; rs10836230; rs10836233; rs10836234; rs11032717; rs1107573; rs11606946; rs12284341; rs12807961; rs12808450; rs1323690; rs1535718; rs1535719; rs1535720; rs1535721; rs16925525; rs2073057; rs208678; rs208679; rs208681; rs208682; rs208683; rs2231828; rs2266624; rs2266630; rs2296144; rs409598; rs554518; rs7109862; rs7114869; rs7118388; rs7928156; rs7941147; rs7944397; rs7949972

# Metabolic_Enzyme_3_General_References:
3755525; 3755526; 11728823; 8282800; 12665801; 6548744; 10666617; 10656833; 11134921

# Metabolic_Enzyme_3_References:
15878720; 16100910; 8312381; 8608175

# Metabolic_Enzyme_4_ID:
7375

# Metabolic_Enzyme_4_Name:
Superoxide dismutase [Mn], mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
Not Available

# Metabolic_Enzyme_4_Gene_Name:
SOD2

# Metabolic_Enzyme_4_Protein_Sequence:
>Superoxide dismutase Mn, mitochondrial precursor
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK

# Metabolic_Enzyme_4_Number_of_Residues:
222

# Metabolic_Enzyme_4_Molecular_Weight:
24722

# Metabolic_Enzyme_4_Theoretical_pI:
8.45

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  metal ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on superoxide radicals as acceptor
Function:  superoxide dismutase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  oxygen and reactive oxygen species metabolism
Process:  superoxide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
2 O2*- + 2 H+ = O2 + H2O2

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF02777:Sod_Fe_C;
PF00081:Sod_Fe_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.15.1.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
34709

# Metabolic_Enzyme_4_SwissProt_ID:
SODM_HUMAN (P04179)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SOD2

# Metabolic_Enzyme_4_Geneatlas_id:
SOD2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11180

# Metabolic_Enzyme_4_PDB_ID:
1LUV

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>669 bp
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGCTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCAACGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X59445

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_4_Locus:
6q25.3

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
2462451; 3684581; 3399391; 2831093; 1988135; 1699607; 7702755; 14574404; 6386798; 7895732; 7498159; 9150946; 1394426; 8605177; 9537988; 9537987; 10852710; 11580280

# Metabolic_Enzyme_4_References:
10564779; 11866117; 11985892; 1649087

# Metabolic_Enzyme_5_ID:
5515

# Metabolic_Enzyme_5_Name:
Aspartate aminotransferase, cytoplasmic

# Metabolic_Enzyme_5_Synonyms:
Transaminase A; Glutamate oxaloacetate transaminase 1

# Metabolic_Enzyme_5_Gene_Name:
GOT1

# Metabolic_Enzyme_5_Protein_Sequence:
>Aspartate aminotransferase, cytoplasmic
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ

# Metabolic_Enzyme_5_Number_of_Residues:
413

# Metabolic_Enzyme_5_Molecular_Weight:
46248

# Metabolic_Enzyme_5_Theoretical_pI:
7.01

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  transaminase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00272  Cysteine metabolism;
 map00330  Arginine and proline metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00401  Novobiocin biosynthesis;
 map00710  Carbon fixation;
 map00950  Alkaloid biosynthesis I

# Metabolic_Enzyme_5_Reaction:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.6.1.1

# Metabolic_Enzyme_5_GenBank_ID_Protein:
179067

# Metabolic_Enzyme_5_SwissProt_ID:
AATC_HUMAN (P17174)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
GOT1

# Metabolic_Enzyme_5_Geneatlas_id:
GOT1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:4432

# Metabolic_Enzyme_5_PDB_ID:
1AJS

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1242 bp
ATGGCACCTCCGTCAGTCTTTGCCGAGGTTCCGCAGGCCCAGCCTGTCCTGGTCTTCAAG
CTCACTGCCGACTTCAGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCA
TATCGCACGGATGACTGCCATCCCTGGGTTTTGCCAGTAGTGAAGAAAGTGGAGCAGAAG
ATTGCTAATGACAATAGCCTAAATCACGAGTATCTGCCAATCCTGGGCCTGGCTGAGTTC
CGGAGCTGTGCTTCTCGTCTTGCCCTTGGGGATGACAGCCCAGCACTCAAGGAGAAGCGG
GTAGGAGGTGTGCAATCTTTGGGGGGAACAGGTGCACTTCGAATTGGAGCTGATTTCTTA
GCGCGTTGGTACAATGGAACAAACAACAAGAACACACCTGTCTATGTGTCCTCACCAACC
TGGGAGAATCACAATGCTGTGTTTTCCGCTGCTGGTTTTAAAGACATTCGGTCCTATCGC
TACTGGGATGCAGAGAAGAGAGGATTGGACCTCCAGGGCTTCCTGAATGATCTGGAGAAT
GCTCCTGAGTTCTCCATTGTTGTCCTCCACGCCTGTGCACACAACCCAACTGGGATTGAC
CCAACTCCGGAGCAGTGGAAGCAGATTGCTTCTGTCATGAAGCACCGGTTTCTGTTCCCC
TTCTTTGACTCAGCCTATCAGGGCTTCGCATCTGGAAACCTGGAGAGAGATGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGCTTCGAGTTCTTCTGTGCCCAGTCCTTCTCCAAGAAC
TTCGGGCTCTACAATGAGAGAGTCGGGAATCTGACTGTGGTTGGAAAAGAACCTGAGAGC
ATCCTGCAAGTCCTTTCCCAGATGGAGAAGATCGTGCGGATTACTTGGTCCAATCCCCCC
GCCCAGGGAGCACGAATTGTGGCCAGCACCCTCTCTAACCCTGAGCTCTTTGAGGAATGG
ACAGGTAATGTGAAGACAATGGCTGACCGGATTCTGACCATGAGATCTGAACTCAGGGCA
CGACTAGAAGCCCTCAAAACCCCTGGGACCTGGAACCACATCACTGATCAAATTGGCATG
TTCAGCTTCACTGGGTTGAACCCCAAGCAGGTTGAGTATCTGGTCAATGAAAAGCACATC
TACCTGCTGCCAAGTGGTCGAATCAACGTGAGTGGCTTAACCACCAAAAATCTAGATTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M37400

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_5_Locus:
10q24.1-q25.1

# Metabolic_Enzyme_5_SNPs:
rs2234971; rs2641; rs11867; rs1126878; rs11190083; rs2862611; rs4328160; rs4919310; rs11813054; rs3793935; rs4919308; rs17111658; rs3750897; rs2275952; rs7906501; rs7918062; rs7067702; rs9971275; rs9971274; rs11190087; rs11594790; rs12571181; rs12249347; rs10883343; rs11819158; rs4353208; rs3763793; rs11190088; rs17569447; rs3793933; rs7921465; rs12253915; rs3793934; rs2494651; rs10883341; rs2862612; rs2490280; rs12768505; rs17111665; rs2862613; rs17569578; rs4567385; rs11815136; rs10883342; rs10748775; rs4919309; rs17491012; rs12253861; rs11190081; rs2862614; rs12217584; rs11815637; rs12766044; rs17111645; rs17111694; rs4919311; rs12411568; rs11557841; rs4564264; rs41290500; rs11557840; rs1126927; rs11190082; rs2642; rs1802509; rs1802508; rs41290498; rs34854950; rs12777843; rs35687189; rs11394746; rs34971146; rs34646712; rs35478605; rs34582301; rs3045656; rs12252840; rs35736782; rs11378738; rs7918037; rs41400447; rs7896693; rs5787336; rs9731375; rs35003844; rs11456562; rs11313874; rs12358477; rs10668892; rs12241455; rs41436049; rs5787337; rs9971276; rs35500142; rs35096443; rs11456561; rs2902275; rs7899976; rs13377085; rs12777646; rs10629267; rs12414885; rs35193236; rs11325628; rs12777641; rs34254460; rs1892505; rs12776735; rs12776369; rs4917866; rs12775973; rs11816599; rs6584274; rs33928164; rs10786543; rs7917808; rs11429814; rs35546038; rs10716499; rs35665184; rs11190090; rs34122561; rs2234894; rs10748774; rs10786545; rs11190080; rs11190094; rs1132364; rs11592057; rs11598504; rs17111699; rs17490682; rs2298315; rs2298316; rs2490281; rs2490283; rs2494652; rs2494653; rs2494654; rs2862610; rs34183428; rs3750896; rs3793931; rs3793932; rs4345898; rs4917862; rs4917864; rs4919307; rs7099391; rs7914408; rs7920356

# Metabolic_Enzyme_5_General_References:
1974457; 2241899

# Metabolic_Enzyme_5_References:
10447557; 10789500; 15234195

# Macromolecular_Interacting_Partner_1_ID:
6352

# Macromolecular_Interacting_Partner_1_Name:
Atrial natriuretic peptide receptor B precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
ANP-B; ANPRB; GC-B; Guanylate cyclase B; NPR-B; Atrial natriuretic peptide B-type receptor

# Macromolecular_Interacting_Partner_1_Gene_Name:
NPR2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Atrial natriuretic peptide receptor B precursor
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
GDVEMKGKGKMRTYWLLGERKGPPGLL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1047

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
117024

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.86

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  peptide receptor activity, G-protein coupled
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Signal transduction mechanisms 

# Macromolecular_Interacting_Partner_1_Specific_Function:
Receptor for atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Has guanylate cyclase activity on binding of ligand. The activation order seems to be CNP > BNP > ANP

# Macromolecular_Interacting_Partner_1_Pathway:
map00230  Purine metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
GTP = 3',5'-cyclic GMP + diphosphate

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01094:ANF_receptor;
PF00211:Guanylate_cyc;
PF00069:Pkinase

# Macromolecular_Interacting_Partner_1_Signals:
1-22

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
459-478

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 4.6.1.2

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
5139790

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ANPRB_HUMAN (P20594)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
NPR2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
NPR2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:7944

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>3144 bp
ATGGCGCTGCCATCACTTCTGCTGTTGGTGGCAGCCCTGGCAGGTGGGGTGCGTCCTCCC
GGGGCGCGGAACCTGACGCTGGCGGTGGTGCTGCCAGAACACAACCTGAGCTATGCCTGG
GCCTGGCCACGGGTGGGACCCGCTGTGGCACTAGCTGTGGAGGCTCTGGGCCGGGCACTG
CCCGTGGACCTGCGGTTTGTCAGCTCCGAACTGGAAGGCGCCTGCTCTGAGTACCTGGCA
CCGCTGAGCGCTGTGGACCTCAAGCTGTACCATGACCCCGACCTGCTGTTAGGTCCCGGT
TGCGTGTACCCTGCTGCCTCTGTGGCCCGCTTTGCCTCCCACTGGCGCCTTCCCCTGCTG
ACTGCGGGTGCTGTGGCCTCTGGTTTTTCGGCTAAGAATGACCATTATCGTACCCTGGTT
CGCACTGGCCCCTCTGCTCCCAAGCTGGGTGAGTTTGTGGTGACACTACACGGGCACTTC
AATTGGACTGCCCGTGCTGCCTTGCTGTACCTGGATGCTCGCACAGATGACCGGCCTCAC
TACTTCACCATCGAGGGCGTCTTTGAGGCCCTGCAGGGCAGCAACCTCAGTGTGCAGCAC
CAGGTGTATGCCCGAGAGCCAGGGGGCCCCGAGCAGGCCACCCACTTCATCCGGGCCAAC
GGGCGCATTGTGTATATCTGCGGCCCTCTGGAGATGCTGCATGAGATCCTGCTTCAGGCC
CAGAGGGAGAATCTGACCAATGGGGATTATGTCTTCTTTTACCTGGATGTCTTTGGGGAG
AGTCTCCGTGCAGGCCCCACACGTGCTACAGGCCGGCCCTGGCAGGACAATCGCACCCGG
GAACAGGCCCAGGCCCTCAGAGAGGCCTTTCAGACTGTATTGGTGATCACGTACCGAGAA
CCCCCAAATCCTGAGTATCAGGAATTCCAGAATCGTCTGCTGATAAGAGCCCGGGAAGAC
TTTGGTGTGGAGCTGGGCCCTTCCCTGATGAACCTCATCGCTGGCTGCTTCTATGATGGG
ATCCTGCTATATGCTGAAGTCCTGAATGAGACAATACAGGAAGGAGGCACCCGGGAGGAT
GGACTTCGAATTGTGGAAAAGATGCAGGGACGAAGATATCACGGTGTAACTGGGCTGGTT
GTCATGGACAAGAACAATGACCGAGAGACTGACTTTGTCCTCTGGGCCATGGGAGACCTG
GATTCTGGGGACTTTCAGCCTGCAGCCCACTACTCGGGAGCTGAGAAGCAGATTTGGTGG
ACGGGACGGCCTATTCCCTGGGTGAAGGGGGCTCCTCCCTCGGACAATCCCCCCTGTGCC
TTTGACTTGGACGACCCATCCTGTGATAAAACTCCACTTTCAACCCTGGCAATTGTGGCT
CTGGGCACAGGAATCACCTTCATCATGTTTGGTGTTTCCAGCTTCCTAATTTTCCGAAAG
CTGATGCTGGAGAAGGAGCTGGCTAGCATGTTGTGGCGTATTCGCTGGGAAGAACTGCAG
TTTGGCAACTCAGAGCGTTATCACAAAGGTGCAGGCAGTCGCCTCACACTGTCGCTGCGG
GGATCCAGTTACGGCTCGCTCATGACAGCCCATGGGAAATACCAGATCTTTGCCAACACC
GGTCACTTCAAGGGAAATGTTGTCGCCATCAAACATGTGAATAAGAAGCGCATTGAGCTG
ACCCGGCAGGTTCTGTTTGAACTCAAACATATGAGAGATGTTCAGTTCAACCATCTCACT
CGCTTCATTGGCGCCTGCATAGACCCTCCCAACATTTGCATTGTCACTGAATACTGTCCT
CGTGGGAGTTTACAGGATATTCTAGAAAATGACAGCATCAACTTGGACTGGATGTTTCGT
TATTCACTCATTAATGACCTTGTTAAGGGCATGGCCTTTCTCCACAACAGCATTATTTCA
TCGCATGGGAGTCTCAAGTCCTCCAACTGTGTGGTGGATAGTCGTTTTGTGCTCAAAATC
ACAGACTATGGCCTGGCCAGCTTCCGATCAACTGCTGAACCTGATGACAGCCATGCCCTC
TATGCCAAGAAGCTGTGGACTGCCCCAGAACTGCTCAGTGGGAACCCCTTGCCAACCACA
GGCATGCAGAAGGCTGACGTCTATAGCTTTGGGATCATCCTGCAGGAGATAGCACTTCGC
AGTGGTCCTTTCTACTTGGAGGGCCTGGACCTCAGCCCCAAAGAGATTGTCCAGAAGGTA
CGAAATGGTCAGCGGCCATATTTCCGGCCAAGCATTGACCGGTCCCAACTGAATGAAGAG
CTAGTTTTGCTGATGGAGCGATGTTGGGCTCAGGACCCAGCTGAGCGGCCAGACTTTGGA
CAGATTAAGGGCTTCATTCGGCGCTTTAACAAGGAGGGTGGCACCAGCATATTGGACAAC
CTCCTGCTGCGCATGGAACAGTATGCCAATAACTTGGAGAAGCTGGTGGAGGAACGCACA
CAGGCCTATCTGGAGGAAAAACGCAAGGCTGAAGCTCTGCTCTACCAAATCCTACCCCAT
TCAGTGGCAGAGCAGTTAAAACGGGGAGAGACTGTACAGGCTGAGGCCTTTGACAGTGTT
ACCATCTACTTCAGTGACATTGTTGGCTTCACAGCATTGTCAGCAGAGAGCACCCCCATG
CAGGTAGTGACACTTCTTAATGACCTGTATACCTGCTTTGATGCCATAATTGACAACTTT
GATGTCTACAAGGTGGAGACGATTGGGGATGCTTACATGGTGGTATCTGGCCTCCCAGGC
CGAAATGGTCAACGCCATGCACCAGAAATTGCTCGTATGGCCCTAGCATTACTAGATGCA
GTTTCTTCCTTTCGCATCCGCCACCGACCCCATGACCAGCTGAGGCTACGCATAGGGGTC
CATACTGGGCCAGTCTGTGCTGGGGTTGTTGGCCTGAAGATGCCCCGTTATTGTCTTTTT
GGAGACACAGTGAACACTGCTTCTCGAATGGAGTCTAATGGTCAAGCGCTGAAGATCCAT
GTCTCCTCTACCACCAAGGATGCCCTAGATGAGCTAGGATGCTTCCAGCTAGAGCTTCGG
GGGGATGTGGAAATGAAGGGAAAAGGAAAGATGCGAACATACTGGCTCTTAGGAGAGCGG
AAAGGACCTCCTGGACTCCTGTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB005647

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:9

# Macromolecular_Interacting_Partner_1_Locus:
9p21-p12

# Macromolecular_Interacting_Partner_1_SNPs:
rs2228580; rs5812; rs7043647; rs10758325; rs10814276; rs1322044; rs7034957; rs3793543; rs7021716; rs7031237; rs7864199; rs1407295; rs2236290; rs2236289; rs2890702; rs13288085; rs1078081; rs10758324; rs12347878; rs12553111; rs5816; rs28931581; rs28929479; rs3729731; rs3729730; rs28931582; rs5813; rs28764009; rs5815; rs4512468; rs5024028; rs13293624; rs28764011; rs34474231; rs28764014; rs4879927; rs10603903; rs35323702; rs12005446; rs35457827; rs12686421; rs34532812; rs28764012; rs3069788; rs11328092; rs35713408; rs35484064; rs1407296; rs28764008; rs1322043; rs35170845; rs28764010; rs35145770; rs28764013; rs34349173; rs3750438; rs3842217; rs34754193; rs10972585; rs35743544; rs10758323; rs10972591; rs12337802; rs12338156; rs12342037; rs13292880; rs13294264; rs13294295; rs13299765; rs2145923; rs2281645; rs2281646; rs3763631; rs3808864; rs3808865; rs4879928; rs4879929; rs6476491; rs7848310; rs7866903; rs7873145; rs878749; rs878750

# Macromolecular_Interacting_Partner_1_General_References:
2570358; 10082481; 10073597

# Macromolecular_Interacting_Partner_1_References:
1353937; 1361362; 1981669; 7910045

# Macromolecular_Interacting_Partner_2_ID:
7803

# Macromolecular_Interacting_Partner_2_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_2_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_2_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_2_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_2_References:
1334706; 4253964; 6331862; 9461633

# Macromolecular_Interacting_Partner_3_ID:
8254

# Macromolecular_Interacting_Partner_3_Name:
Oligopeptide transporter, small intestine isoform

# Macromolecular_Interacting_Partner_3_Synonyms:
Peptide transporter 1; Intestinal H(+/peptide cotransporter; Solute carrier family 15 member 1

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC15A1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Oligopeptide transporter, small intestine isoform
MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFV
ALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPV
HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTII
TPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCI
GFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQ
GSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKK
MAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP
MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQK
PEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQ
PNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSV
TGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVC
VIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
708

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
78807

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.64

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  transporter activity
Function:  peptide transporter activity
Function:  oligopeptide transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  peptide transport
Process:  oligopeptide transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00854:PTR2

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
1-21
54-74
83-103
119-139
162-182
199-219
277-297
328-348
362-382
585-605
620-640
646-666

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
773588

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S15A1_HUMAN (P46059)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC15A1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC15A1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10920

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>2127 bp
ATGGGAATGTCCAAATCACACAGTTTCTTTGGTTATCCCCTGAGCATCTTCTTCATCGTG
GTCAATGAGTTTTGCGAAAGATTTTCCTACTATGGAATGCGAGCAATCCTGATTCTGTAC
TTCACAAATTTCATCAGCTGGGATGATAACCTGTCCACCGCCATCTACCATACGTTTGTG
GCTCTGTGCTACCTGACGCCAATTCTCGGAGCTCTTATCGCCGACTCGTGGCTGGGAAAG
TTCAAGACCATTGTGTCGCTCTCCATTGTCTACACAATTGGACAAGCAGTCACCTCAGTA
AGCTCCATTAATGACCTCACAGACCACAACCATGATGGCACCCCCGACAGCCTTCCTGTG
CACGTGGTGCTGTCCTTGATCGGCCTGGCCCTGATAGCTCTCGGGACTGGAGGAATCAAA
CCCTGTGTGTCTGCGTTTGGTGGAGATCAGTTTGAAGAGGGCCAGGAGAAACAAAGAAAC
AGATTTTTTTCCATCTTTTACTTGGCTATTAATGCTGGAAGTTTGCTTTCCACAATCATC
ACACCCATGCTCAGAGTTCAACAATGTGGAATTCACAGTAAACAAGCTTGTTACCCACTG
GCCTTTGGGGTTCCTGCTGCTCTCATGGCTGTAGCCCTGATTGTGTTTGTCCTTGGCAGT
GGGATGTACAAGAAGTTCAAGCCACAGGGCAACATCATGGGTAAAGTGGCCAAGTGCATC
GGTTTTGCCATCAAAAATAGATTTAGGCATCGGAGTAAGGCATTTCCCAAGAGGGAGCAC
TGGCTGGACTGGGCTAAAGAGAAATACGATGAGCGGCTCATCTCCCAAATTAAGATGGTT
ACGAGGGTGATGTTCCTGTATATTCCACTCCCAATGTTCTGGGCCTTGTTTGACCAGCAG
GGCTCCAGGTGGACACTGCAGGCAACAACTATGTCCGGGAAAATCGGAGCTCTTGAAATT
CAGCCCGATCAGATGCAGACCGTGAACGCCATCCTGATCGTGATCATGGTCCCGATCTTC
GATGCTGTGCTGTACCCTCTCATTGCAAAATGTGGCTTCAATTTCACCTCCTTGAAGAAG
ATGGCAGTTGGCATGGTCCTGGCCTCCATGGCCTTTGTGGTGGCTGCCATCGTGCAGGTG
GAAATCGATAAAACTCTTCCAGTCTTCCCCAAAGGAAACGAAGTCCAAATTAAAGTTTTG
AATATAGGAAACAATACCATGAATATATCTCTTCCTGGAGAGATGGTGACACTTGGCCCA
ATGTCTCAAACAAATGCATTTATGACTTTTGATGTAAACAAACTGACAAGGATAAACATT
TCTTCTCCTGGATCACCAGTCACTGCTGTAACTGACGACTTCAAGCAGGGCCAACGCCAC
ACGCTTCTAGTGTGGGCCCCCAATCACTACCAGGTGGTAAAGGATGGTCTTAACCAGAAG
CCAGAAAAAGGGGAAAATGGAATCAGATTTGTAAATACTTTTAACGAGCTCATCACCATC
ACAATGAGTGGGAAAGTTTATGCAAACATCAGCAGCTACAATGCCAGCACATACCAGTTT
TTTCCTTCTGGCATAAAAGGCTTCACAATAAGCTCAACAGAGATTCCGCCACAATGTCAA
CCTAATTTCAATACTTTCTACCTTGAATTTGGTAGTGCTTATACCTATATAGTCCAAAGG
AAGAATGACAGCTGCCCTGAAGTGAAGGTGTTTGAAGATATTTCAGCCAACACAGTTAAC
ATGGCTCTGCAAATCCCGCAGTATTTTCTTCTCACCTGTGGCGAAGTGGTCTTCTCTGTC
ACGGGATTGGAATTCTCATATTCTCAGGCTCCTTCCAACATGAAGTCGGTGCTTCAGGCA
GGATGGCTGCTGACCGTGGCTGTTGGCAACATCATTGTGCTCATCGTGGCAGGGGCAGGC
CAGTTCAGCAAACAGTGGGCCGAGTACATTCTATTTGCCGCGTTGCTTCTGGTCGTCTGT
GTAATTTTTGCCATCATGGCTCGGTTCTATACTTACATCAACCCAGCGGAGATCGAAGCT
CAATTTGATGAGGATGAAAAGAAAAACAGACTGGAAAAGAGTAACCCATATTTCATGTCA
GGGGCCAATTCACAGAAACAGATGTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
U13173

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_3_Locus:
13q33-q34

# Macromolecular_Interacting_Partner_3_SNPs:
rs2297322; rs4646227; rs8187820; rs8187838; rs2274828; rs2274827; rs8187821; rs8187830; rs1339067; rs8187840; rs8187832; rs8187836; rs8187823; rs1289389; rs4646234; rs7331216; rs4646206; rs9554495; rs3783002; rs1768043; rs950906; rs950905; rs2297319; rs2802390; rs1331251; rs1289393; rs883962; rs8187826; rs6491441; rs9300504; rs2185207; rs3825428; rs11069326; rs6491438; rs1289394; rs4772122; rs4608199; rs4646215; rs4646221; rs9557034; rs1289390; rs7318138; rs4772124; rs10492578; rs7992817; rs9557033; rs914300; rs7326286; rs4646214; rs8001466; rs4772126; rs9517416; rs1289392; rs9584911; rs9513475; rs12853199; rs11618107; rs9513470; rs3782997; rs4772132; rs2263235; rs6491446; rs1768042; rs9584906; rs4771316; rs2066079; rs4646217; rs2297318; rs3782996; rs2390092; rs9513474; rs9300505; rs6491440; rs4772130; rs4772129; rs4646216; rs2390106; rs6491445; rs4646209; rs7997477; rs7998137; rs4772131; rs7983644; rs6491448; rs7338228; rs9584919; rs4646212; rs3782999; rs6491447; rs4646222; rs3783001; rs9584921; rs2297320; rs9517424; rs7324010; rs6491442; rs3782994; rs9554498; rs4350452; rs7990232; rs9513478; rs2297321; rs7339292; rs1576644; rs10454525; rs12427740; rs9517413; rs4646213; rs3783000; rs11069325; rs3782993; rs12853441; rs7331065; rs7995801; rs9584925; rs7335599; rs9783535; rs16955752; rs9582259; rs2802392; rs8000767; rs4646223; rs914301; rs12867528; rs9517428; rs4771315; rs11618901; rs9517414; rs9517417; rs9517419; rs6491449; rs12100089; rs7325784; rs1892503; rs7335430; rs9557036; rs9517406; rs4646224; rs9582260; rs7336318; rs7335961; rs7984336; rs4772128; rs9513477; rs7983080; rs6491443; rs1756988; rs9554496; rs7983051; rs7327300; rs9517423; rs1782672; rs8002712; rs4646208; rs7994445; rs9300508; rs6491444; rs2149494; rs9584922; rs12586112; rs16955725; rs1289391; rs8187837; rs12853368; rs4646207; rs9584916; rs9300509; rs1934064; rs6491437; rs6491450; rs16955728; rs9517409; rs3825429; rs4366582; rs7986109; rs4646235; rs7981545; rs1782674; rs3737087; rs35329772; rs1126836; rs11354027; rs9513468; rs35432591; rs9584926; rs809536; rs35418914; rs34315299; rs12876638; rs34823897; rs9584908; rs4644732; rs12866917; rs11409104; rs9584903; rs9554497; rs7321176; rs1782673; rs3831216; rs946402; rs9557037; rs12866940; rs4646220; rs34508410; rs7334595; rs9584915; rs7989936; rs34165009; rs34520897; rs9783588; rs4646210; rs8002282; rs34503390; rs12428457; rs2017894; rs12020036; rs9584909; rs11433753; rs17701332; rs1756989; rs11347963; rs5806073; rs12855763; rs35205657; rs9582257; rs35484191; rs34373331; rs9582258; rs12855410; rs9584914; rs9584924; rs2149495; rs7489959; rs4646230; rs11838832; rs35539223; rs9584907; rs946401; rs35520800; rs11309992; rs7990839; rs812231; rs11842116; rs9517420; rs35799720; rs11390654; rs7333570; rs4646218; rs35424966; rs9645892; rs3782995; rs12868220; rs12877013; rs11378347; rs9513467; rs9557035; rs9584904; rs12870597; rs9517418; rs9517421; rs34760702; rs9584913; rs28504043; rs6145194; rs17575153; rs35159274; rs4646231; rs3837539; rs33982897; rs4646219; rs1625299; rs4646228; rs9517405; rs1768044; rs10454524; rs35038911; rs10684111; rs12184574; rs34078820; rs34679094; rs35949883; rs7985400; rs9584902; rs34518098; rs1756990; rs9517430; rs4772127; rs35314410; rs4001067; rs35217525; rs12867080; rs9584905; rs35414294; rs9584912; rs33989824; rs7982748; rs9517412; rs9513476; rs7985707; rs4646226; rs9517411; rs9513471; rs4646232; rs7335161; rs12867104; rs2802391; rs7981646; rs13378672; rs4646211; rs7328065; rs34440379; rs36004561; rs35857425; rs932950; rs9557038; rs4646229; rs12871129; rs34922002; rs35251576; rs35455856; rs34803894; rs28514895; rs34078760; rs9584928; rs7993908; rs28672752; rs28573788; rs35039740; rs34298145; rs9517431; rs11405904; rs10851093; rs11840154; rs12863327; rs1614209; rs1626391; rs1629183; rs16955723; rs17655581; rs1768047; rs1782671; rs2066080; rs2251861; rs2252341; rs2390105; rs2802388; rs2802389; rs34170268; rs7317249; rs7320943; rs7326447; rs7329621; rs8187812; rs8187816; rs8187817; rs8187818; rs8187819; rs8187825; rs8187829; rs8187833; rs8187834; rs8187835; rs8187841; rs955052; rs955053; rs9554493; rs9557030; rs9557031; rs9557032; rs9557043; rs9557045; rs956839; rs9584900

# Macromolecular_Interacting_Partner_3_General_References:
7896779

# Macromolecular_Interacting_Partner_3_References:
15630234

# Macromolecular_Interacting_Partner_4_ID:
8209

# Macromolecular_Interacting_Partner_4_Name:
Runt-related transcription factor 2

# Macromolecular_Interacting_Partner_4_Synonyms:
Core-binding factor, alpha 1 subunit; CBF-alpha 1; Acute myeloid leukemia 3 protein; Oncogene AML-3; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEA2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Osteoblast- specific transcription factor 2; OSF-2

# Macromolecular_Interacting_Partner_4_Gene_Name:
RUNX2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Runtrelated transcription factor 2
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQ
QQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPN
FLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPS
LFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYD
QSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKS
QAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHT
YLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGS
TLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
521

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
56648

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.05

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  transcription factor activity
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits MYST4-dependent transcriptional activation

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00853:Runt;
PF08504:RunxI

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
RUNX2_HUMAN (Q13950)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
RUNX2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
RUNX2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10472

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF001450

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p21

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
9182765; 9434946; 14574404; 9651525; 9233771; 12145306; 9207800; 10521292; 10545612; 10689183; 10980549

# Macromolecular_Interacting_Partner_4_References:
15102049

# Macromolecular_Interacting_Partner_5_ID:
8202

# Macromolecular_Interacting_Partner_5_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_5_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_5_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_5_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_5_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q22

# Macromolecular_Interacting_Partner_5_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_5_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_5_References:
16046297; 3095942

# Macromolecular_Interacting_Partner_6_ID:
8424

# Macromolecular_Interacting_Partner_6_Name:
Oligopeptide transporter, kidney isoform

# Macromolecular_Interacting_Partner_6_Synonyms:
Peptide transporter 2; Kidney H(+/peptide cotransporter; Solute carrier family 15 member 2

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC15A2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Oligopeptide transporter, kidney isoform
MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSY
YGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLV
YVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEER
TRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSK
IYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRHDWLDWAAEKYPKQLIMDVKALT
RVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFD
FVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAARVEIKINEMAPAQPGPQEVFLQVLN
LADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHS
VQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVG
EDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIED
IPANKMSIRWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIV
LVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMI
KLETKKTKL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
729

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
81942

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.38

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  peptide transporter activity
Function:  oligopeptide transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  peptide transport
Process:  oligopeptide transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_6_Specific_Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00854:PTR2

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
58-78
88-108
115-135
140-160
184-204
218-238
296-316
344-364
381-401
568-588
612-632
644-664
675-695

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
999213

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
S15A2_HUMAN (Q16348)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC15A2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC15A2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:10921

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2190 bp
ATGAATCCTTTCCAGAAAAATGAGTCCAAGGAAACTCTTTTTTCACCTGTCTCCATTGAA
GAGGTACCACCTCGACCACCTAGCCCTCCAAAGAAGCCATCTCCGACAATCTGTGGCTCC
AACTATCCACTGAGCATTGCCTTCATTGTGGTGAATGAATTCTGCGAGCGCTTTTCCTAT
TATGGAATGAAAGCTGTGCTGATCCTGTATTTCCTGTATTTCCTGCACTGGAATGAAGAT
ACCTCCACATCTATATACCATGCCTTCAGCAGCCTCTGTTATTTTACTCCCATCCTGGGA
GCAGCCATTGCTGACTCGTGGTTGGGAAAATTCAAGACAATCATCTATCTCTCCTTGGTG
TATGTGCTTGGCCATGTGATCAAGTCCTTGGGTGCCTTACCAATACTGGGAGGACAAGTG
GTACACACAGTCCTATCATTGATCGGCCTGAGTCTAATAGCTTTGGGGACAGGAGGCATC
AAACCCTGTGTGGCAGCTTTTGGTGGAGACCAGTTTGAAGAAAAACATGCAGAGGAACGG
ACTAGATACTTCTCAGTCTTCTACCTGTCCATCAATGCAGGGAGCTTGATTTCTACATTT
ATCACACCCATGCTGAGAGGAGATGTGCAATGTTTTGGAGAAGACTGCTATGCATTGGCT
TTTGGAGTTCCAGGACTGCTCATGGTAATTGCACTTGTTGTGTTTGCAATGGGAAGCAAA
ATATACAATAAACCACCCCCTGAAGGAAACATAGTGGCTCAAGTTTTCAAATGTATCTGG
TTTGCTATTTCCAATCGTTTCAAGAACCGTTCTGGAGACATTCCAAAGCGACACGACTGG
CTAGACTGGGCGGCTGAGAAATATCCAAAGCAGCTCATTATGGATGTAAAGGCACTGACC
AGGGTACTATTCCTTTATATCCCATTGCCCATGTTCTGGGCTCTTTTGGATCAGCAGGGT
TCACGATGGACTTTGCAAGCCATCAGGATGAATAGGAATTTGGGGTTTTTTGTGCTTCAG
CCGGACCAGATGCAGGTTCTAAATCCCCTTCTGGTTCTTATCTTCATCCCGTTGTTTGAC
TTTGTCATTTATCGTCTGGTCTCCAAGTGTGGAATTAACTTCTCATCACTTAGGAAAATG
GCTGTTGGTATGATCCTAGCATGCCTGGCATTTGCAGTTGCGGCACGTGTAGAGATAAAA
ATAAATGAAATGGCCCCAGCCCAGCCAGGTCCCCAGGAGGTTTTCCTACAAGTCTTGAAT
CTGGCAGATGATGAGGTGAAGGTGACAGTGGTGGGAAATGAAAACAATTCTCTGTTGATA
GAGTCCATCAAATCCTTTCAGAAAACACCACACTATTCCAAACTGCACCTGAAAACAAAA
AGCCAGGATTTTCACTTCCACCTGAAATATCACAATTTGTCTCTCTACACTGAGCATTCT
GTGCAGGAGAAGAACTGGTACAGTCTTGTCATTCGTGAAGATGGGAACAGTATCTCCAGC
ATGATGGTAAAGGATACAGAAAGCAGAACAACCAATGGGATGACAACCGTGAGGTTTGTT
AACACTTTGCATAAAGATGTCAACATCTCCCTGAGTACAGATACCTCTCTCAATGTTGGT
GAAGACTATGGTGTGTCTGCTTATAGAACTGTGCAAAGAGGAGAATACCCTGCAGTGCAC
TGTAGAACAGAAGATAAGAACTTTTCTCTGAATTTGGGTCTTCTAGACTTTGGTGCAGCA
TATCTGTTTGTTATTACTAATAACACCAATCAGGGTCTTCAGGCCTGGAAGATTGAAGAC
ATTCCAGCCAACAAAATGTCCATTCGGTGGCAGCTACCACAATATGCCCTGGTTACAGCT
GGGGAGGTCATGTTCTCTGTCACAGGTCTTGAGTTTTCTTATTCTCAGGCTCCCTCTAGC
ATGAAATCTGTGCTCCAGGCAGCTTGGCTATTGACAATTGCAGTTGGGAATATCATCGTG
CTTGTTGTGGCACAGTTCAGTGGCCTGGTACAGTGGGCCGAATTCATTTTGTTTTCCTGC
CTCCTGCTGGTGATCTGCCTGATCTTCTCCATCATGGGCTACTACTATGTTCCTGTAAAG
ACAGAGGATATGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGATC
AAACTAGAGACCAAGAAGACAAAACTCTGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S78203

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_6_Locus:
3q13.33

# Macromolecular_Interacting_Partner_6_SNPs:
rs1143672; rs2257212; rs1143671; rs1143668; rs1143667; rs1920314; rs1143673; rs2293616; rs1143670; rs1143669; rs1920313; rs2689273; rs2049331; rs1357531; rs866928; rs2877568; rs874741; rs866929; rs1523519; rs2049330; rs2332054; rs2141615; rs1881998; rs11914993; rs2293615; rs953730; rs3805134; rs874742; rs4305455; rs9812515; rs2332055; rs9289182; rs9830721; rs3817601; rs11920521; rs2293612; rs9862977; rs3762822; rs6803757; rs2257214; rs2689283; rs1882000; rs3805132; rs2877566; rs866927; rs2689284; rs2257132; rs3805138; rs1881997; rs9289183; rs2293614; rs866926; rs1316397; rs1920302; rs1316301; rs2257119; rs9849724; rs2250067; rs1882002; rs9842387; rs6780234; rs2689288; rs3762819; rs7635449; rs2700424; rs1881999; rs4583698; rs3762821; rs2332052; rs1920303; rs2332046; rs2332044; rs2689282; rs9816071; rs2877569; rs6438687; rs2689272; rs2689291; rs9836339; rs2700421; rs7645647; rs9815649; rs4465981; rs9863155; rs9815756; rs1881995; rs2332053; rs6770115; rs2178415; rs9289181; rs2250065; rs9816215; rs2332050; rs6794360; rs2700426; rs2700420; rs7623754; rs2257120; rs2257123; rs2293613; rs2257109; rs2332051; rs9866936; rs2700425; rs9868185; rs9850685; rs9870245; rs4118376; rs9822474; rs9843053; rs1920315; rs3932367; rs2257115; rs2257124; rs2700423; rs11920547; rs9871534; rs9845790; rs1920319; rs2689292; rs7637569; rs9835875; rs3817599; rs3792596; rs6799626; rs11918861; rs12330644; rs9713652; rs2951471; rs6791876; rs9827390; rs9810707; rs7619800; rs9829070; rs12496036; rs9837144; rs3792597; rs9713657; rs9713895; rs2262494; rs2293611; rs1920317; rs11707541; rs9827473; rs11924085; rs9713900; rs2689277; rs6414289; rs9831607; rs10934562; rs2293608; rs9811473; rs6775183; rs9714033; rs9714238; rs9714239; rs11922812; rs2332049; rs1881996; rs2877567; rs1882004; rs2700416; rs6765799; rs9831723; rs9844954; rs2689281; rs9828753; rs1344279; rs2332043; rs17203299; rs1882003; rs4285028; rs4603998; rs11720061; rs11720058; rs10470412; rs12498028; rs17854312; rs1920305; rs4388019; rs41271413; rs2332045; rs34567530; rs35119143; rs7652204; rs2332047; rs28790275; rs41271421; rs36202666; rs4432693; rs11425666; rs41271419; rs3215371; rs35902163; rs3926094; rs1920304; rs10703708; rs12489233; rs13068438; rs11371908; rs34226020; rs34273335; rs28481518; rs36038750; rs1920301; rs12629742; rs36019076; rs13319084; rs35492489; rs2689289; rs3805136; rs13093033; rs1920300; rs35943712; rs7428886; rs6780559; rs35032381; rs7629964; rs5852283; rs28861465; rs2293610; rs3215370; rs36045594; rs34837785; rs34909578; rs13064029; rs41271415; rs13317021; rs34611077; rs1920318; rs6790936; rs28529298; rs35406725; rs3840261; rs28844001; rs28871629; rs4250029; rs3047583; rs13086454; rs11425667; rs28789687; rs36159816; rs41271417; rs36177447; rs2332048; rs35879145; rs34900621; rs13077082; rs34542794; rs3762820; rs35694140; rs28390159; rs34354261; rs2689287; rs28823352; rs9828757; rs35577523; rs35480514; rs2091666; rs34227248; rs9877671; rs10470411; rs1136995; rs11924158; rs1343979; rs13860; rs1920307; rs1920308; rs1920309; rs1920310; rs1920311; rs1920312; rs2689275; rs35446226; rs35538837; rs4422354; rs6438689; rs6790281; rs7615571; rs7650341; rs9289180; rs9790267; rs9822660; rs9829181; rs9867460; rs9871743

# Macromolecular_Interacting_Partner_6_General_References:
7756356

# Macromolecular_Interacting_Partner_6_References:
11474785; 15056281; 17034769

# Macromolecular_Interacting_Partner_7_ID:
7913

# Macromolecular_Interacting_Partner_7_Name:
Heat shock 70 kDa protein 1

# Macromolecular_Interacting_Partner_7_Synonyms:
HSP70.1; HSP70-1/HSP70-2

# Macromolecular_Interacting_Partner_7_Gene_Name:
HSPA1A

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Heat shock 70 kDa protein 1
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
641

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
70053

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.31

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Posttranslational modification, protein turnover, chaperones 

# Macromolecular_Interacting_Partner_7_Specific_Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00012:HSP70

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
188488

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
HSP71_HUMAN (P08107)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
HSPA1A

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
HSPA1A

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5232

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1926 bp
ATGGCCAAAGCCGCGGCGATCGGCATCGACCTGGGCACCACCTACTCCTGCGTGGGGGTG
TTCCAACACGGCAAGGTGGAGATCATCGCCAACGACCAGGGCAACCGCACCACCCCCAGC
TACGTGGCCTTCACGGACACCGAGCGGCTCATCGGGGATGCGGCCAAGAACCAGGTGGCG
CTGAACCCGCAGAACACCGTGTTTGACGCGAAGCGCCTGATTGGCCGCAAGTTCGGCGAC
CCGGTGGTGCAGTCGGACATGAAGCACTGGCCTTTCCAGGTGATCAACGACGGAGACAAG
CCCAAGGTGCAGGTGAGCTACAAGGGGGAGACCAAGGCATTCTACCCCGAGGAGATCTCG
TCCATGGTGCTGACCAAGATGAAGGAGATCGCCGAGGCGTACCTGGGCTACCCGGTGACC
AACGCGGTGATCACCGTGCCGGCCTACTTCAACGACTCGCAGCGCCAGGCCACCAAGGAT
GCGGGTGTGATCGCGGGGCTCAACGTGCTGCGGATCATCAACGAGCCCACGGCCGCCGCC
ATCGCCTACGGCCTGGACAGAACGGGCAAGGGGGAGCGCAACGTGCTCATCTTTGACCTG
GGCGGGGGCACCTTCGACGTGTCCATCCTGACGATCGACGACGGCATCTTCGAGGTGAAG
GCCACGGCCGGGGACACCCACCTGGGTGGGGAGGACTTTGACAACAGGCTGGTGAACCAC
TTCGTGGAGGAGTTCAAGAGAAAACACAAGAAGGACATCAGCCAGAACAAGCGAGCCGTG
AGGCGGCTGCGCACCGCCTGCGAGAGGGCCAAGAGGACCCTGTCGTCCAGCACCCAGGCC
AGCCTGGAGATCGACTCCCTGTTTGAGGGCATCGACTTCTACACGTCCATCACCAGGGCG
AGGTTCGAGGAGCTGTGCTCCGACCTGTTCCGAAGCACCCTGGAGCCCGTGGAGAAGGCT
CTGCGCGACGCCAAGCTGGACAAGGCCCAGATTCACGACCTGGTCCTGGTCGGGGGCTCC
ACCCGCATCCCCAAGGTGCAGAAGCTGCTGCAGGACTTCTTCAACGGGCGCGACCTGAAC
AAGAGCATCAACCCCGACGAGGCTGTGGCCTACGGGGCGGCGGTGCAGGCGGCCATCCTG
ATGGGGGACAAGTCCGAGAACGTGCAGGACCTGCTGCTGCTGGACGTGGCTCCCCTGTCG
CTGGGGCTGGAGACGGCCGGAGGCGTGATGACTGCCCTGATCAAGCGCAACTCCACCATC
CCCACCAAGCAGACGCAGATCTTCACCACCTACTCCGACAACCAACCCGGGGTGCTGATC
CAGGTGTACGAGGGCGAGAGGGCCATGACGAAAGACAACAATCTGTTGGGGCGCTTCGAG
CTGAGCGGCATCCCTCCGGCCCCCAGGGGCGTGCCCCAGATCGAGGTGACCTTCGACATC
GATGCCAACGGCATCCTGAACGTCACGGCCACGGACAAGAGCACCGGCAAGGCCAACAAG
ATCACCATCACCAACGACAAGGGCCGCCTGAGCAAGGAGGAGATCGAGCGCATGGTGCAG
GAGGCGGAGAAGTACAAAGCGGAGGACGAGGTGCAGCGCGAGAGGGTGTCAGCCAAGAAC
GCCCTGGAGTCCTACGCCTTCAACATGAAGAGCGCCGTGGAGGATGAGGGGCTCAAGGGC
AAGATCAGCGAGGCCGACAAGAAGAAGGTGCTGGACAAGTGTCAAGAGGTCATCTCGTGG
CTGGACGCCAACACCTTGGCCGAGAAGGACGAGTTTGAGCACAAGAGGAAGGAGCTGGAG
CAGGTGTGTAACCCCATCATCAGCGGACTGTACCAGGGTGCCGGTGGTCCCGGGCCTGGG
GGCTTCGGGGCTCAGGGTCCCAAGGGAGGGTCTGGGTCAGGCCCCACCATTGAGGAGGTA
GATTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M59828

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_7_Locus:
6p21.3

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
1700760; 3931075; 14574404; 2538825; 3786141; 10216320

# Macromolecular_Interacting_Partner_7_References:
12498304; 16945336; 16949620; 16984587

End of HMDB00033

Beginning of HMDB00034
# Accession_No:
HMDB00034

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-22 17:00:42

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenine

# Description:
Adenine is a purine base. Adenine is found in both DNA and RNA. Adenine is a fundamental component of adenine nucleotides. Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose; it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between chemical reactions.
Purine inborn errors of metabolism (IEM) are serious hereditary disorders, which should be suspected in any case of neonatal fitting, failure to thrive, recurrent infections, neurological deficit, renal disease, self-mutilation and other manifestations. Investigation usually starts with uric acid (UA) determination in urine and plasma. (OMIM 300322, 229600, 603027, 232400, 232600, 232800, 201450, 220150, 232200, 162000, 164050, 278300). (PMID: 17052198, 17520339)

# Synonyms:
1,6-Dihydro-6-iminopurine; 1H-Purin-6-amine; 1H-Purine-6-amine; 3,6-Dihydro-6-iminopurine; 6-Amino-1H-purine; 6-Amino-3H-purine; 6-Amino-7H-purine; 6-Amino-9H-purine; 6-Aminopurine; 6-amino-Purine; 9H-Purin-6-amine; 9H-Purin-6-yl-amin; 9H-Purine-6-amine; 9H-purin-6-ylamine; Ade; Adenin; Adenine; Adeninimine; Vitamin B4

# Chemical_IUPAC_Name:
7H-purin-6-amine

# Chemical_Formula:
C5H5N5

# Chemical_Structure:
tbl_chemical:::HMDB00034_ZOOM.png:::119283144823038917

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00034_THUMB.png:::11928314464392350

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aromatic amine; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
DNA component; Component of Purine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
135.05449

# Molecular_Weight_Avg:
135.12671

# Smiles_String_isomeric:
NC1=NC=NC2=C1NC=N2

# Smiles_String_canonical:
NC1=NC=NC2=C1NC=N2

# KEGG_Compound_ID:
C00147

# BioCyc_ID:
ADENINE

# PubChem_CID:
190

# PubChem_SID:
8144939; 11405393; 828509; 11377286; 10322142; 832226; 7987265; 11361989; 589178; 836808; 149245; 11487391; 823652; 7885703; 826914; 11370094; 585680; 610762; 11484162; 826232; 11369124; 7847102; 11109934; 854817; 11493705; 822670; 823493; 828511; 10408453; 7853710; 11494920; 11371752; 826855; 841461; 11488399; 11373133; 827713; 830718; 834956; 823885; 584702; 830750; 823157; 5385494; 11367532; 819247; 830693; 11375694; 834959; 11341806; 3135000; 820745; 854374; 822025; 11490432; 12016036; 11375582; 3447; 11537598; 7885710; 826016; 11378265; 10317179; 11364970; 8025303; 825133; 5344002; 10534154; 7885885; 11366562; 11364000; 855041; 8150497; 2101; 830741; 2102; 825880; 830162

# OMIM_ID:
102600; 103220

# Metagene_ID:
ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT): 406

# BiGG_ID:
34039

# Wikipedia_ID:
Adenine

# METLIN_ID:
85

# Ref_ID:
12951489; 15063338; 15994977; 16055624; 17126311; 15715490; 401462; 16613999; 6656991; 12829005; 11985597

# ChEBI_ID:
16708

# CAS_Registry_Number:
73-24-5

# InChI:
InChI=1/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

# Synthesis_Reference:
Journal of the Chemical Society  (1943),     386-7.

# Melting_Point:
360 oC

# Melting_Point_predicted:
116.0 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1.03 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
11.5 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-0.09 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.24 [Predicted by ALOGPS]; -0.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Adenine.htm:::1132562191927978699

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Adenine.mol:::1132723802593374589

# SDF_File_[Text]:
tbl_chemical:::HMDB00034.sdf:::119283144312182809

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00034.pdb:::119283144469572592

# PDB_ID:
1AHA

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AHA.txt:::113272089925084109

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_PRESAT_expanded_2.gif:::114168246164641225

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_presat.zip:::1175124391570355147

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041008_P00_02_HW_1DP_Assigned.png:::11465975787836228

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::73_24_5p_presat_JM.GIF:::1132883818453983363

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041008_P00_02_HW_1DP_presat.zip:::115203982965426049

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794.png:::114805794258284634

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794.zip:::114805794258629976

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041008_P00_02_HW_2DHSQC_794_Assigned.png:::115023651715193146

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenine.gif:::1132732101000585129

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00034_peaks.txt:::1156309500777524545

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenine_C.gif:::1132737663175405845

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00034_peaks.txt:::1156310692490605820

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00034L.png:::117555261869239412; Medium Energy:tbl_ms:::HMDB00034M.png:::11755526700088852; High Energy:tbl_ms:::HMDB00034H.png:::117555270868050927

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000060.png:::116890825170340102

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000060.txt:::116890825204663179

# Cellular_Location:
Cytoplasm; Nucleus; Extracellular; lysosome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Urine

# Concentration_[Normal]:
Blood	0.300 (0.200-0.400)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Blood	 0.64 +/- 0.15	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0 - 0.2	uM	Adult:>18_yrs_old	Both	Normal	6656991


# Concentration_[Abnormal]:
Urine	7.11	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenine Phosphoribosyltransferase (APRT) Deficiency	17126311
Blood	3.57	uM	Adult:>18_yrs_old	Both	Adenine phosphoribosyltransferase (APRT) deficiency.	17126311
Cerebrospinal_Fluid(CSF)	0.5 (0 - 18.0)	uM	Children:1-13_yrs_old	N/A	Bacterial meningitis	12581805
Cerebrospinal_Fluid(CSF)	0.35 (0 - 23.4)	uM	Children:1-13_yrs_old	N/A	Tuberculous meningitis	12581805
Cerebrospinal_Fluid(CSF)	0.96 (0 - 12.0)	uM	Children:1-13_yrs_old	N/A	Viral meningitis	12581805


# Associated_Disorders:
Adenine Phosphoribosyltransferase (APRT) Deficiency; Adenine phosphoribosyltransferase (APRT) deficiency.; Bacterial meningitis; Friedreich's Ataxia; Heterotopia; Tuberculous meningitis; Viral meningitis

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg

# KEGG_Images:
map00230;map00760

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml

# Metabolic_Enzyme_1_ID:
5806

# Metabolic_Enzyme_1_Name:
Thymidine phosphorylase precursor

# Metabolic_Enzyme_1_Synonyms:
TdRPase; TP; Platelet-derived endothelial cell growth factor; PD-ECGF; Gliostatin

# Metabolic_Enzyme_1_Gene_Name:
ECGF1

# Metabolic_Enzyme_1_Protein_Sequence:
>Thymidine phosphorylase precursor
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ

# Metabolic_Enzyme_1_Number_of_Residues:
482

# Metabolic_Enzyme_1_Molecular_Weight:
49956

# Metabolic_Enzyme_1_Theoretical_pI:
5.19

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_1_Reaction:
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02885:Glycos_trans_3N;
PF00591:Glycos_transf_3;
PF07831:PYNP_C

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.2.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
189701

# Metabolic_Enzyme_1_SwissProt_ID:
TYPH_HUMAN (P19971)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ECGF1

# Metabolic_Enzyme_1_Geneatlas_id:
ECGF1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:3148

# Metabolic_Enzyme_1_PDB_ID:
1UOU

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1449 bp
ATGGCAGCCTTGATGACCCCGGGAACCGGGGCCCCACCCGCGCCTGGTGACTTCTCCGGG
GAAGGGAGCCAGGGACTTCCCGACCCTTCGCCAGAGCCCAAGCAGCTCCCGGAGCTGATC
CGCATGAAGCGAGACGGAGGCCGCCTGAGCGAAGCGGACATCAGGGGCTTCGTGGCCGCT
GTGGTGAATGGGAGCGCGCAGGGCGCACAGATCGGGGCCATGCTGATGGCCATCCGACTT
CGGGGCATGGATCTGGAGGAGACCTCGGTGCTGACCCAGGCCCTGGCTCAGTCGGGACAG
CAGCTGGAGTGGCCAGAGGCCTGGCGCCAGCAGCTTGTGGACAAGCATTCCACAGGGGGT
GTGGGTGACAAGGTCAGCCTGGTCCTCGCACCTGCCCTGGCGGCATGTGGCTGCAAGGTG
CCAATGATCAGCGGACGTGGTCTGGGGCACACAGGAGGCACCTTGGATAAGCTGGAGTCT
ATTCCTGGATTCAATGTCATCCAGAGCCCAGAGCAGATGCAAGTGCTGCTGGACCAGGCG
GGCTGCTGTATCGTGGGTCAGAGTGAGCAGCTGGTTCCTGCGGACGGAATCCTATATGCA
GCCAGAGATGTGACAGCCACCGTGGACAGCCTGCCACTCATCACAGCCTCCATTCTCAGT
AAGAAACTCGTGGAGGGGCTGTCCGCTCTGGTGGTGGACGTTAAGTTCGGAGGGGCCGCC
GTCTTCCCCAACCAGGAGCAGGCCCGGGAGCTGGCAAAGACGCTGGTTGGCGTGGGAGCC
AGCCTAGGGCTTCGGGTCGCGGCAGCGCTGACCGCCATGGACAAGCCCCTGGGTCGCTGC
GTGGGCCACGCCCTGGAGGTGGAGGAGGCGCTGCTCTGCATGGACGGCGCAGGCCCGCCA
GACTTAAGGGACCTGGTCACCACGCTCGGGGGCGCCCTGCTCTGGCTCAGCGGACACGCG
GGGACTCAGGCTCAGGGCGCTGCCCGGGTGGCCGCGGCGCTGGACGACGGCTCGGCCCTT
GGCCGCTTCGAGCGGATGCTGGCGGCGCAGGGCGTGGATCCCGGTCTGGCCCGAGCCCTG
TGCTCGGGAAGTCCCGCAGAACGCCGGCAGCTGCTGCCTCGCGCCCGGGAGCAGGAGGAG
CTGCTGGCGCCCGCAGATGGCACCGTGGAGCTGGTCCGGGCGCTGCCGCTGGCGCTGGTG
CTGCACGAGCTCGGGGCCGGGCGCAGCCGCGCTGGGGAGCCGCTCCGCCTGGGGGTGGGC
GCAGAGCTGCTGGTCGACGTGGGTCAGAGGCTGCGCCGTGGGACCCCCTGGCTCCGCGTG
CACCGGGACGGCCCCGCGCTCAGCGGCCCGCAGAGCCGCGCCCTGCAGGAGGCGCTCGTA
CTCTCCGACCGCGCGCCATTCGCCGCCCCCTCGCCCTTCGCAGAGCTCGTTCTGCCGCCG
CAGCAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M63193

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_1_Locus:
22q13|22q13.33

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
2467210; 1570012; 1400349; 1590793; 9924029; 12177387

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5634

# Metabolic_Enzyme_2_Name:
S-methyl-5-thioadenosine phosphorylase

# Metabolic_Enzyme_2_Synonyms:
5'- methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase

# Metabolic_Enzyme_2_Gene_Name:
MTAP

# Metabolic_Enzyme_2_Protein_Sequence:
>Smethyl5thioadenosine phosphorylase
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH

# Metabolic_Enzyme_2_Number_of_Residues:
283

# Metabolic_Enzyme_2_Molecular_Weight:
31236

# Metabolic_Enzyme_2_Theoretical_pI:
7.21

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
S-methyl-5-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.2.28

# Metabolic_Enzyme_2_GenBank_ID_Protein:
847724

# Metabolic_Enzyme_2_SwissProt_ID:
MTAP_HUMAN (Q13126)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MTAP

# Metabolic_Enzyme_2_Geneatlas_id:
MTAP

# Metabolic_Enzyme_2_hgnc_id:
HGNC:7413

# Metabolic_Enzyme_2_PDB_ID:
1SD2

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>852 bp
ATGGCCTCTGGCACCACCACCACCGCCGTGAAGATTGGAATAATTGGTGGAACAGGCCTG
GATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAG
CCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCATCCTCCTTGCAAGG
CATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCT
TTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAG
GAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGA
CCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATG
GCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGA
CTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGG
GCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCA
GAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGAT
TATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTG
AAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCC
ACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTA
CCAAGACATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
U22233

# Metabolic_Enzyme_2_Chromosome_Location:
Not Available

# Metabolic_Enzyme_2_Locus:
Not Available

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
7604019; 8650244; 8687427; 10404592

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5676

# Metabolic_Enzyme_3_Name:
Adenine phosphoribosyltransferase

# Metabolic_Enzyme_3_Synonyms:
APRT

# Metabolic_Enzyme_3_Gene_Name:
APRT

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE


# Metabolic_Enzyme_3_Number_of_Residues:
180

# Metabolic_Enzyme_3_Molecular_Weight:
19608

# Metabolic_Enzyme_3_Theoretical_pI:
5.82

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  adenine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base salvage
Process:  adenine salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.2.7

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28819

# Metabolic_Enzyme_3_SwissProt_ID:
APT_HUMAN (P07741)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
APRT

# Metabolic_Enzyme_3_Geneatlas_id:
APRT

# Metabolic_Enzyme_3_hgnc_id:
HGNC:626

# Metabolic_Enzyme_3_PDB_ID:
1ORE

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_3_Gene_Sequence:
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
Y00486

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_3_Locus:
16q24

# Metabolic_Enzyme_3_SNPs:
rs8191472; rs8191473; rs2242172; rs8191478; rs8191483; rs3214057; rs8191477; rs8191489; rs8191488; rs8191480; rs8191492; rs2242173; rs8191470; rs8191487; rs8191484; rs8191493; rs8191475; rs8191471; rs537641; rs3826075; rs564235; rs535070; rs8191463; rs3759950; rs541276; rs3759952; rs3759951; rs8191468; rs8191460; rs8191465; rs3826074; rs8191464; rs8191469; rs8191466; rs8191461; rs8191458; rs8191494; rs28999113; rs35148077; rs35095508; rs3169258; rs2911456; rs34926513; rs8191476; rs8191491; rs8191482; rs8191495; rs8191486; rs8191481; rs8191479; rs8191474; rs8191485; rs8191490; rs8191457; rs35132384; rs8191459; rs12929472; rs28712013; rs12929307; rs8191467; rs11076715; rs11076716; rs11076718; rs1141390; rs11640595; rs12932340; rs12935469; rs15829; rs1799825; rs1834065; rs2070256; rs2303271; rs2303272; rs2303273; rs3177509; rs3218720; rs3218721; rs3218722; rs3218723; rs3218724; rs3218725; rs3218726; rs3218727; rs3218728; rs3218729; rs3218730; rs3743548; rs3784890; rs3826065; rs3826066; rs3826067; rs3826068; rs3826069; rs3826070; rs3826071; rs4356464; rs4503779; rs4695; rs475667; rs480727; rs507329; rs510862; rs550269; rs555812; rs559678; rs565211; rs572275; rs8059203; rs8191502; rs8191504; rs8191509

# Metabolic_Enzyme_3_General_References:
3684585; 3554238; 3531209; 12665801; 1746557; 7915931; 3680503; 3343350; 1353080; 11243733

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5805

# Metabolic_Enzyme_4_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_4_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_4_Gene_Name:
NP

# Metabolic_Enzyme_4_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_4_Number_of_Residues:
289

# Metabolic_Enzyme_4_Molecular_Weight:
32118

# Metabolic_Enzyme_4_Theoretical_pI:
6.95

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_4_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_4_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
NP

# Metabolic_Enzyme_4_Geneatlas_id:
NP

# Metabolic_Enzyme_4_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_4_PDB_ID:
1RT9

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_4_Locus:
14q13.1

# Metabolic_Enzyme_4_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_4_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5937

# Metabolic_Enzyme_5_Name:
Adenosine deaminase

# Metabolic_Enzyme_5_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_5_Gene_Name:
ADA

# Metabolic_Enzyme_5_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_5_Number_of_Residues:
363

# Metabolic_Enzyme_5_Molecular_Weight:
40765

# Metabolic_Enzyme_5_Theoretical_pI:
5.80

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_5_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_5_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_5_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ADA

# Metabolic_Enzyme_5_Geneatlas_id:
ADA

# Metabolic_Enzyme_5_hgnc_id:
HGNC:186

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_5_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_5_Locus:
20q12-q13.11

# Metabolic_Enzyme_5_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_5_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_5_References:
16256072

# Macromolecular_Interacting_Partner_1_ID:
6985

# Macromolecular_Interacting_Partner_1_Name:
Adenosine A3 receptor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ADORA3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Adenosine A3 receptor
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
318

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
36185

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.04

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A3 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
15-37
49-72
85-106
127-148
178-198
232-255
262-284

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
349449

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
AA3R_HUMAN (P33765)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ADORA3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ADORA3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:268

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>957 bp
ATGCCCAACAACAGCACTACTCTGTCATTGGCCAATGTTACCTACATCACCATGGAAATT
TTCATTGGACTCTGCGCCATAGTGGGCAACGTGCTGGTCATCTGCGTGGTCAAGCTGAAC
CCCAGCCTGCAGACCACCACCTTCTATTTCATTGTCTCTCTAGCCCTGGCTGACATTGCT
GTTGGGGTGCTGGTCATGCCTTTGGCCATTGTTGTCAGCCTGGGCATCACAATCCACTTC
TACAGCTGCCTTTTTATGACTTGCCTACTGCTTATCTTTACCCACGCCTCCATCATGTCC
TTGCTGGCCATCGCTGTGGACCGATACTTGCGGGTCAAGCTTACCGTCAGATACAAGAGG
GTCACCACTCACAGAAGAATATGGCTGGCCCTGGGCCTTTGCTGGCTGGTGTCATTCCTG
GTGGGATTGACCCCCATGTTTGGCTGGAACATGAAACTGACCTCAGAGTACCACAGAAAT
GTCACCTTCCTTTCATGCCAATTTGTTTCCGTCATGAGAATGGACTACATGGTATACTTC
AGCTTCCTCACCTGGATTTTCATCCCCCTGGTTGTCATGTGCGCCATCTATCTTGACATC
TTTTACATCATTCGGAACAAACTCAGTCTGAACTTATCTAACTCCAAAGAGACAGGTGCA
TTTTATGGACGGGAGTTCAAGACGGCTAAGTCCTTGTTTCTGGTTCTTTTCTTGTTTGCT
CTGTCATGGCTGCCTTTATCTATCATCAACTGCATCATCTACTTTAATGGTGAGGTACCA
CAGCTTGTGCTGTACATGGGCATCCTGCTGTCCCATGCCAACTCCATGATGAACCCTATC
GTCTATGCCTATAAAATAAAGAAGTTCAAGGAAACCTACCTTTTGATCCTCAAAGCCTGT
GTGGTCTGCCATCCCTCTGATTCTTTGGACACAAGCATTGAGAAGAATTCTGAGTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
L20463

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1p13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs2800889; rs35511654; rs2275797; rs2229155; rs1415792; rs1415793; rs923; rs1544223; rs3394; rs1544224; rs3393; rs7737; rs9025; rs2252739; rs2800907; rs2065992; rs1361134; rs2798566; rs2800898; rs2800908; rs2095731; rs3767602; rs7547951; rs7544118; rs1361133; rs1780556; rs6684144; rs7517018; rs12127443; rs2275796; rs17027794; rs6672858; rs6537702; rs3767601; rs1361135; rs2789539; rs2252740; rs2800888; rs6659177; rs3767597; rs2032007; rs17027796; rs2789541; rs1628597; rs7549031; rs2262952; rs2252198; rs2800906; rs3767599; rs2252197; rs2032006; rs1962125; rs2800902; rs2786996; rs10857885; rs10857886; rs10857887; rs10776728; rs11102286; rs2298191; rs10776727; rs17027791; rs35986308; rs2789537; rs17852706; rs35789323; rs1417372; rs1591993; rs41282520; rs3908963; rs41282522; rs2298190; rs2789540; rs7512445; rs10697750; rs11434724; rs11434889; rs11434726; rs12137500; rs34799830; rs11434722; rs11804136; rs28651435; rs11311759; rs6660209; rs41282516; rs12125678; rs12126504; rs6678079; rs10697753; rs35262507; rs11321711; rs10602162; rs11434888; rs11337394; rs35344043; rs34457698; rs35537319; rs6668383; rs10686710; rs10697749; rs11434890; rs34492052; rs34460629; rs10596470; rs11434725; rs35259782; rs10686711; rs10602166; rs10602160; rs35611547; rs10697748; rs10618863; rs2486265; rs41290394; rs12136686; rs28528074; rs10614217; rs11434892; rs35767792; rs12126471; rs7548753; rs35584333; rs11434723; rs1780557; rs10602164; rs3831359; rs11273132; rs28760561; rs34567608; rs34093957; rs34272338; rs10686709; rs10602163; rs10686708; rs28757604; rs41282518; rs10614218; rs11434891; rs2488943; rs35689000; rs34693250; rs11314583; rs3835605; rs2265691; rs11102285; rs3216055; rs34273340; rs10711590; rs3904838; rs34622560; rs5777061; rs35606913; rs34225315; rs35077141; rs1054680; rs10857888; rs10857889; rs10857890; rs11102281; rs11102284; rs11102290; rs11102291; rs11102292; rs11576988; rs11810580; rs12039025; rs12042310; rs12142663; rs12566343; rs1361136; rs1419091; rs1538251; rs17027773; rs17027867; rs17027880; rs2211494; rs2298189; rs2786992; rs2786994; rs2786995; rs2800886; rs4593826; rs4839139; rs6537704; rs6537705; rs6692745; rs6703267

# Macromolecular_Interacting_Partner_1_General_References:
8399349; 8234299; 12975309; 11214319

# Macromolecular_Interacting_Partner_1_References:
16033270; 16305531; 17149867

# Macromolecular_Interacting_Partner_2_ID:
8758

# Macromolecular_Interacting_Partner_2_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_2_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_2_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_2_Locus:
11q13

# Macromolecular_Interacting_Partner_2_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_2_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8857

# Macromolecular_Interacting_Partner_3_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_3_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_3_Locus:
10q22.1

# Macromolecular_Interacting_Partner_3_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_3_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_3_References:
Not Available

End of HMDB00034

Beginning of HMDB00036
# Accession_No:
HMDB00036

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-07-17 14:06:26

# biospider_lastupdate:
2007-07-24 17:08:12

# Common_Name:
Taurocholic acid

# Description:
Taurocholic acid is the product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic (a bile purging agent). Hydrolysis of taurocholic acid yields taurine, a nonessential amino acid.
Taurocholic acid is one of the main components of urinary nonsulfated bile acids in Biliary Atresia. Raised levels of the bile acid taurocholate in the fetal serum in obstetric cholestasis may result in the development of a fetal dysrhythmia and in sudden intra-uterine death. (PMID: 3944741, 11256973)
A bile acid. Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. 
Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. 
Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues. (PMID: 11316487, 16037564, 12576301, 11907135)


# Synonyms:
3a,7a,12a-Trihydroxy-5b-cholanic acid-24-taurine; Cholaic acid; Cholic acid taurine conjugate; Cholyltaurine; N-Choloyltaurine; n-choloyl-Taurine

# Chemical_IUPAC_Name:
2-[4-[(3R,5S,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

# Chemical_Formula:
C26H45NO7S

# Chemical_Structure:
tbl_chemical:::HMDB00036_ZOOM.png:::119283146132157772

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00036_THUMB.png:::119283145913587514

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Bile Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
sulfonic acid; secondary carboxylic acid amide; secondary alcohol

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
515.29163

# Molecular_Weight_Avg:
515.70300

# Smiles_String_isomeric:
CC(CCC(=O)NCCS(O)(=O)=O)C1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CCC4(C)C3C[C@H](O)C12C

# Smiles_String_canonical:
CC(CCC(=O)NCCS(O)(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C

# KEGG_Compound_ID:
C05122

# BioCyc_ID:
CPD-3743

# PubChem_CID:
440567

# PubChem_SID:
7544

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
45150

# Wikipedia_ID:
Taurocholate

# METLIN_ID:
5104

# Ref_ID:
8359688; 7913319; 9322525; 12891557; 16178789; 9508530; 10480314; 16014767; 12631271; 10100884; 12883481; 16606610; 2757635; 11927623; 11160372; 3683732; 11408531; 16078136

# ChEBI_ID:
28865

# CAS_Registry_Number:
81-24-3

# InChI:
InChI=1/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15?,16-,17+,18?,19?,20?,21+,22-,24?,25?,26?/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
125 oC

# Melting_Point_predicted:
167.8 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
7.17 mg/mL [MEYLAN,WM et al. (1996)]; 0.0771 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
0.79 [Predicted by ALOGPS]; 2.7 [Predicted by PubChem via XLOGP]; 0.01 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00036_msds.html:::1132562192197607836

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05122.mol:::1132723802687473294

# SDF_File_[Text]:
tbl_chemical:::HMDB00036.sdf:::119283145231260128

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00036.pdb:::119283145740282670

# PDB_ID:
1AQL

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AQL.txt:::1132720899375129179

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7-Epicholic acid.gif:::1132732101218673419

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00036_peaks.txt:::1156309501819829201

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7-Epicholic acid_C.gif:::1132737663816572184

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00036_peaks.txt:::1156310693510858719

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; Extracellular; peroxisome

# Tissue_Location:
Fibroblasts; Hepatocyte; Intestine; Liver; Liver Predominantly; Myelin

# deuterated:
No

# Biofluid_Location:
Bile; Blood

# Concentration_[Normal]:
Blood	0.20	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Bile	9910 (9600-10220)	uM	Adult:>18_yrs_old	Both	Normal	11160372


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Acute Pancreatitis; Cholestasis

# Pathway_Names:
Bile acid biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00120

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5821

# Metabolic_Enzyme_1_Name:
Bile acid CoA:amino acid N-acyltransferase

# Metabolic_Enzyme_1_Synonyms:
BAT; BACAT; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase

# Metabolic_Enzyme_1_Gene_Name:
BAAT

# Metabolic_Enzyme_1_Protein_Sequence:
>Bile acid CoA:amino acid Nacyltransferase
MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDL
NHASSLGGDY
MGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVA
SAPKASLTLERWYVAPGVTRI
KVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRA
SLLASRGFASLALAYHNYEDLPRKPEVTDLEY
FEEAANFLLRHPKVFGSGVGVVSVCQG
VQIGLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPH
SAQLISTNALGLLELY
RTFETTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKN
NWTLL
SYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVT
SQL

# Metabolic_Enzyme_1_Number_of_Residues:
418

# Metabolic_Enzyme_1_Molecular_Weight:
46300

# Metabolic_Enzyme_1_Theoretical_pI:
7.00

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  thiolester hydrolase activity
Function:  CoA hydrolase activity
Function:  palmitoyl-CoA hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs

# Metabolic_Enzyme_1_Pathway:
map00120  Bile acid biosynthesis;
 map00430  Taurine and hypotaurine metabolism

# Metabolic_Enzyme_1_Reaction:
palmitoyl-CoA + H2O = CoA + palmitate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF08840:BAAT_C;
PF04775:Bile_Hydr_Trans

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.3.1.65;EC 3.1.2.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
532505

# Metabolic_Enzyme_1_SwissProt_ID:
BAAT_HUMAN (Q14032)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BAAT

# Metabolic_Enzyme_1_Geneatlas_id:
BAAT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:932

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1257 bp

ATGATCCAGTTGACAGCTACCCCTGTGAGTGCACTTGTTGATGAGCCAGTGCATATCCG
AGCTACAGGCC
TGATTCCCTTTCAGATGGTGAGTTTTCAGGCATCACTGGAAGATGAAA
ACGGAGACATGTTTTATTCTCA
AGCCCACTATAGGGCCAATGAATTCGGTGAGGTGGAC
CTGAATCATGCTTCTTCACTTGGAGGGGATTAT
ATGGGAGTCCACCCCATGGGTCTCTT
CTGGTCTCTGAAACCTGAAAAGCTATTAACAAGACTGTTGAAAA
GAGATGTGATGAATA
GGCCTTTCCAGGTCCAAGTAAAACTTTATGACTTAGAGTTAATAGTGAACAATAA
AGTT
GCCAGTGCTCCAAAGGCCAGCCTGACTTTGGAGAGGTGGTATGTGGCACCTGGTGTCACA
CGAATT
AAGGTTCGAGAAGGCCGCCTTCGAGGAGCTCTCTTTCTCCCTCCAGGAGAGGG
TCTCTTCCCAGGGGTAA
TTGATTTGTTTGGTGGTTTGGGTGGGCTGCTTGAATTTCGGG
CCAGCCTCCTAGCCAGTCGTGGCTTCGC
CTCCTTGGCCTTGGCTTACCATAACTATGAA
GACCTGCCCCGCAAACCAGAAGTAACAGATTTGGAATAT
TTTGAGGAGGCTGCCAACTT
TCTCCTGAGACATCCAAAGGTCTTTGGCTCAGGCGTTGGGGTAGTCTCTG
TATGTCAAG
GAGTACAGATTGGACTATCTATGGCTATTTACCTAAAGCAAGTCACAGCCACGGTACTTA
T
TAATGGGACCAACTTTCCTTTTGGCATTCCACAGGTATATCATGGTCAGATCCATCAG
CCCCTTCCCCAT
TCTGCACAATTAATATCCACCAATGCCTTGGGGTTACTAGAGCTCTA
TCGCACTTTTGAGACAACTCAAG
TTGGGGCCAGTCAATATTTGTTTCCTATTGAAGAGG
CCCAGGGGCAATTCCTCTTCATTGTAGGAGAAGG
TGATAAGACTATCAACAGCAAAGCA
CACGCTGAACAAGCCATAGGACAGCTGAAGAGACATGGGAAGAAC
AACTGGACCCTGCT
ATCTTACCCTGGGGCAGGCCACCTGATAGAACCTCCCTATTCTCCTCTGTGCTGTG
CCT
CAACGACCCACGATTTGAGGTTACACTGGGGAGGAGAGGTGATCCCACACGCAGCTGCAC
AGGAACA
TGCTTGGAAGGAGATCCAGAGATTTCTCAGGAAGCACCTCATTCCAGATGTG
ACCAGTCAACTCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
L34081

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q22.3

# Metabolic_Enzyme_1_SNPs:
rs1572983; rs1226149; rs7043029; rs1226148; rs2229594; rs3824471; rs10819923; rs11791228; rs1226146; rs1891218; rs16936057; rs11560557; rs11496612; rs1226147; rs10120345; rs13294625; rs1341762; rs7048634; rs1341761; rs11792588; rs10989484; rs11788495; rs7848855; rs10114241; rs1341760; rs2417252; rs1341763; rs10760793; rs16920259; rs12336316; rs12350797; rs12351725; rs12338315; rs2417251; rs12341413; rs4322060; rs16920270; rs11793528; rs1226151; rs10118584; rs10123392; rs1226150; rs28937579; rs41281027; rs34425366; rs34962203; rs35281640; rs35538457; rs41274983; rs41281023; rs34155990; rs34005912; rs1135370; rs12115514; rs41274981; rs35109318; rs11351334; rs5899439; rs1057381; rs3847297; rs11420217; rs41281025; rs28599990; rs11524206; rs34334602; rs41301517; rs41316534; rs1057380; rs11433573; rs4595182; rs28447257; rs11349375; rs12350768; rs12379847; rs33919057; rs34003904; rs7037661; rs3081772; rs12004919; rs10989483; rs12341591; rs34603354; rs12683613; rs10124497; rs10989481; rs10989485; rs34755395; rs34701662; rs34724095; rs34197213; rs10123365; rs35371378; rs10989482; rs11787566; rs10122439; rs12342218; rs10119499; rs10120225; rs10118966; rs10819924; rs10989478; rs10989480; rs10989486; rs11790161; rs11793356; rs11793745; rs11795072; rs11795175; rs12348863; rs12376826; rs16920288; rs1857027; rs4742813; rs7023837; rs7023948; rs7023972; rs7033167; rs7847420

# Metabolic_Enzyme_1_General_References:
8034703; 12704386

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5297

# Metabolic_Enzyme_2_Name:
85 kDa calcium-independent phospholipase A2

# Metabolic_Enzyme_2_Synonyms:
iPLA2; CaI- PLA2; Group VI phospholipase A2; GVI PLA2

# Metabolic_Enzyme_2_Gene_Name:
PLA2G6

# Metabolic_Enzyme_2_Protein_Sequence:
>85 kDa calciumindependent phospholipase A2
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG
VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
ALWETEVYIYEHREEFQKLIQLLLSP

# Metabolic_Enzyme_2_Number_of_Residues:
806

# Metabolic_Enzyme_2_Molecular_Weight:
89904

# Metabolic_Enzyme_2_Theoretical_pI:
7.28

# Metabolic_Enzyme_2_GO_Classification:
Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity

# Metabolic_Enzyme_2_Pathway:
map00564  Glycerophospholipid metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Metabolic_Enzyme_2_Reaction:
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00023:Ank

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.1.1.4

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3142700

# Metabolic_Enzyme_2_SwissProt_ID:
PA2G6_HUMAN (O60733)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
PLA2G6

# Metabolic_Enzyme_2_Geneatlas_id:
PLA2G6

# Metabolic_Enzyme_2_hgnc_id:
HGNC:9039

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Isoform LH-iPLA2:Membrane; peripheral membrane protein. Isoform SH-iPLA2:Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>2421 bp
ATGCAGTTCTTTGGCCGCCTGGTCAATACCTTCAGTGGCGTCACCAACTTGTTCTCTAAC
CCATTCCGGGTGAAGGAGGTGGCTGTGGCCGACTACACCTCGAGTGACCGAGTTCGGGAG
GAAGGGCAGCTGATTCTGTTCCAGAACACTCCCAACCGCACCTGGGACTGCGTCCTGGTC
AACCCCAGGAACTCACAGAGTGGATTCCGACTCTTCCAGCTGGAGTTGGAGGCTGACGCC
CTAGTGAATTTCCATCAGTATTCTTCCCAGCTGCTACCCTTCTATGAGAGCTCCCCTCAG
GTCCTGCACACTGAGGTCCTGCAGCACCTGACCGACCTCATCCGTAACCACCCCAGCTGG
TCAGTGGCCCACCTGGCTGTGGAGCTAGGGATCCGCGAGTGCTTCCATCACAGCCGTATC
ATCAGCTGTGCCAATTGCGCGGAGAACGAGGAGGGCTGCACACCCCTGCACCTGGCCTGC
CGCAAGGGTGATGGGGAGATCCTGGTGGAGCTGGTGCAGTACTGCCACACTCAGATGGAT
GTCACCGACTACAAGGGAGAGACCGTCTTCCATTATGCTGTCCAGGGTGACAATTCTCAG
GTGCTGCAGCTCCTTGGAAGGAACGCAGTGGCTGGCCTGAACCAGGTGAATAACCAAGGG
CTGACCCCGCTGCACCTGGCCTGCCAGCTGGGGAAGCAGGAGATGGTCCGCGTGCTGCTG
CTGTGCAATGCTCGGTGCAACATCATGGGCCCCAACGGCTACCCCATCCACTCGGCCATG
AAGTTCTCTCAGAAGGGGTGTGCGGAGATGATCATCAGCATGGACAGCAGCCAGATCCAC
AGCAAAGACCCCCGTTACGGAGCCAGCCCCCTCCACTGGGCCAAGAACGCAGAGATGGCC
CGCATGCTGCTGAAACGGGGCTGCAACGTGAACAGCACCAGCTCCGCGGGGAACACGGCC
CTGCACGTGGCGGTGATGCGCAACCGCTTCGACTGTGCCATAGTGCTGCTGACCCACGGG
GCCAACGCGGATGCCCGCGGAGAGCACGGCAACACCCCGCTGCACCTGGCCATGTCGAAA
GACAACGTGGAGATGATCAAGGCCCTCATCGTGTTCGGAGCAGAAGTGGACACCCCGAAT
GACTTTGGGGAGACTCCTACATTCCTAGCCTCCAAAATCGGCAGACTTGTCACCAGGAAG
GCGATCTTGACTCTGCTGAGAACCGTGGGGGCCGAATACTGCTTCCCACCCATCCACGGG
GTCCCCGCGGAGCAGGGCTCTGCAGCGCCACATCATCCCTTCTCCCTGGAAAGAGCTCAG
CCCCCACCGATCAGCCTAAACAACCTAGAACTACAGGATCTCATGCACATCTCACGGGCC
CGGAAGCCAGCGTTCATCCTGGGCTCCATGAGGGACGAGAAGCGGACCCACGACCACCTG
CTGTGCCTGGATGGAGGAGGAGTGAAAGGCCTCATCATCATCCAGCTCCTCATCGCCATC
GAGAAGGCCTCGGGTGTGGCCACCAAGGACCTGTTTGACTGGGTGGCGGGCACCAGCACT
GGAGGCATCCTGGCCCTGGCCATTCTGCACAGTAAGTCCATGGCCTACATGCGCGGCATG
TACTTTCGCATGAAGGATGAGGTGTTCCGGGGCTCCAGGCCCTACGAGTCGGGGCCCCTG
GAGGAGTTCCTGAAGCGGGAGTTTGGGGAGCACACCAAGATGACGGACGTCAGGAAACCC
AAGGTGATGCTGACAGGGACACTGTCTGACCGGCAGCCGGCTGAACTCCACCTCTTCCGG
AACTACGATGCTCCAGAAACTGTCCGGGAGCCTCGTTTCAACCAGAACGTTAACCTCAGG
CCTCCAGCTCAGCCCTCAGACCAGCTGGTGTGGCGGGCGGCCCGAAGCAGCGGGGCAGCT
CCTACTTACTTCCGACCCAATGGGCGCTTCCTGGACGGTGGGCTGCTGGCCAACAACCCC
ACGCTGGATGCCATGACCGAGATCCATGAGTACAATCAGGACCTGATCCGCAAGGGTCAG
GCCAACAAGGTGAAGAAACTCTCCATCGTTGTCTCCCTGGGGACAGGGAGGTCCCCACAA
GTGCCTGTGACCTGTGTGGATGTCTTCCGTCCCAGCAACCCCTGGGAGCTGGCCAAGACT
GTTTTTGGGGCCAAGGAACTGGGCAAGATGGTGGTGGACTGTTGCACGGATCCAGACGGG
CGGGCTGTGGACCGGGCACGGGCCTGGTGCGAGATGGTCGGCATCCAGTACTTCAGATTG
AACCCCCAGCTGGGGACGGACATCATGCTGGATGAGGTCAGTGACACAGTGCTGGTCAAC
GCCCTCTGGGAGACCGAGGTCTACATCTATGAGCACCGCGAGGAGTTCCAGAAGCTCATC
CACCTGCTGCTCTCACCCTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF064594

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_2_Locus:
22q13.1

# Metabolic_Enzyme_2_SNPs:
rs11570606; rs11570680; rs11570605; rs2413502; rs11570679; rs2267369; rs4384; rs2267371; rs133029; rs133006; rs2277844; rs2267370; rs738322; rs133007; rs4378; rs2413503; rs133009; rs738321; rs738320; rs132991; rs4379; rs133012; rs132989; rs9610911; rs133017; rs133014; rs132995; rs132998; rs11570601; rs738323; rs6001045; rs133019; rs9306323; rs4380; rs2092180; rs133008; rs133013; rs133015; rs132999; rs9610910; rs4385; rs132992; rs75387; rs133016; rs132994; rs133021; rs4381; rs4382; rs133018; rs11570598; rs132993; rs133001; rs133022; rs132996; rs5756947; rs6001037; rs133003; rs11570602; rs4820318; rs8142004; rs132997; rs4383; rs6001038; rs133023; rs4820320; rs11570599; rs6001040; rs16998801; rs11570603; rs133024; rs132985; rs132966; rs2076112; rs2016755; rs731821; rs9619724; rs2076118; rs5750542; rs6001030; rs132946; rs84473; rs1807559; rs4987198; rs6001029; rs4820314; rs2005974; rs4821751; rs2284066; rs6001034; rs4821740; rs3827354; rs6001031; rs3788535; rs3891103; rs2267367; rs2235346; rs8135333; rs7286105; rs5756921; rs4375; rs2284062; rs3788532; rs4820317; rs6001020; rs2076116; rs2076113; rs6001026; rs6001014; rs2012725; rs2235345; rs6001033; rs5756931; rs4821746; rs5756940; rs2235347; rs3788536; rs1807712; rs5750546; rs3788533; rs2267368; rs132954; rs5756922; rs2076117; rs11570645; rs9622746; rs6001028; rs6001022; rs132976; rs738317; rs4376; rs5756934; rs132941; rs6001027; rs2284059; rs8135937; rs2076115; rs11570753; rs132972; rs11570734; rs2272831; rs11570641; rs4497; rs736129; rs132979; rs11089864; rs11570681; rs5995538; rs132987; rs11570736; rs11570651; rs11570658; rs2284063; rs132988; rs6001018; rs132977; rs4377; rs11570682; rs11089868; rs132975; rs132944; rs3900948; rs4821741; rs2235344; rs6001023; rs4821747; rs2018663; rs3788534; rs2072867; rs11570724; rs11570761; rs132973; rs3827355; rs4987197; rs11570710; rs5750547; rs10427700; rs132953; rs11570678; rs11570666; rs6001021; rs11570647; rs10483197; rs6001035; rs2284067; rs5756926; rs5750549; rs5756932; rs6001015; rs132960; rs11570690; rs5756929; rs2076114; rs4820315; rs132986; rs2284060; rs12485185; rs132952; rs11570649; rs132959; rs9622732; rs7290177; rs11570608; rs11570739; rs11570762; rs11570717; rs10427916; rs11570737; rs132964; rs11570701; rs11570721; rs11570660; rs132969; rs9622738; rs11570670; rs11570744; rs12167576; rs132982; rs11570683; rs11266975; rs5995542; rs9622743; rs2284061; rs132978; rs5750548; rs11570750; rs11570707; rs11570687; rs11570667; rs11089869; rs6001036; rs5750544; rs132974; rs11570751; rs11570727; rs11570630; rs11913405; rs132984; rs11570639; rs4821742; rs11570732; rs11570635; rs5756933; rs4820316; rs5756930; rs11912233; rs11570674; rs11570677; rs11570609; rs10427908; rs2284065; rs11570715; rs11570748; rs11704062; rs11570730; rs133010; rs2179236; rs11570662; rs4821743; rs132970; rs11570714; rs6001019; rs16998769; rs11570726; rs11570657; rs11570713; rs11570614; rs16998759; rs11570745; rs5750543; rs4987199; rs11570709; rs11570672; rs11570696; rs11570700; rs11570668; rs11570722; rs16998753; rs11570747; rs11570728; rs11570684; rs11570638; rs132939; rs11913898; rs7284662; rs1005529; rs17563060; rs11570718; rs11570665; rs9610908; rs132971; rs16998755; rs11089865; rs132965; rs11570611; rs11570716; rs11570733; rs11570749; rs11570624; rs4821749; rs5756946; rs9610907; rs1005528; rs11570663; rs11570669; rs11089863; rs5750541; rs11570659; rs132945; rs11570640; rs2281108; rs6001017; rs2284064; rs11570719; rs11570634; rs11570653; rs11570620; rs4821748; rs11570702; rs11570711; rs6001032; rs132950; rs11089870; rs4821753; rs4820321; rs4821752; rs5995543; rs5750556; rs11570590; rs11570589; rs12157473; rs11570646; rs11570607; rs12627857; rs8142389; rs11570604; rs8137578; rs133020; rs36014862; rs35804966; rs2413504; rs34718565; rs133027; rs34139192; rs34365126; rs132990; rs735336; rs133000; rs34190594; rs35260453; rs133025; rs28565947; rs35526737; rs28653361; rs28718653; rs11570597; rs28421906; rs34856995; rs133005; rs11570600; rs2142838; rs133028; rs34809384; rs35231946; rs9607514; rs133004; rs35950199; rs34292639; rs133026; rs133002; rs28428653; rs35530438; rs133011; rs11471646; rs11570697; rs11570673; rs11570618; rs7291586; rs35501048; rs11570699; rs8142930; rs9610905; rs11570689; rs28719740; rs11570626; rs34701842; rs11570694; rs35313235; rs11570757; rs11570656; rs8140579; rs5756920; rs11570637; rs12329956; rs8140454; rs34536395; rs10543970; rs132943; rs11570725; rs132962; rs5995540; rs132956; rs34174459; rs9607512; rs28460110; rs11570616; rs132967; rs11704969; rs11570685; rs11570615; rs132980; rs12162857; rs12162828; rs8141149; rs35709752; rs12165507; rs2235343; rs12167913; rs11570621; rs11441204; rs9610906; rs34612391; rs6001013; rs11570729; rs11570623; rs11570691; rs9610909; rs11570706; rs35883426; rs11570756; rs11570631; rs11570664; rs28695983; rs11570610; rs5845373; rs11570741; rs11570654; rs132937; rs132949; rs11570712; rs5756927; rs10709435; rs11570743; rs11570703; rs9610904; rs34951630; rs6001016; rs34848813; rs11570758; rs35736012; rs11570693; rs34164997; rs11570628; rs11570704; rs12169611; rs11570619; rs5750554; rs11570652; rs11570642; rs34471882; rs5845371; rs2281107; rs7511015; rs132948; rs5756925; rs132935; rs35449261; rs11570661; rs34143772; rs34550422; rs9619722; rs11570612; rs132958; rs11570648; rs9622739; rs11570671; rs35897756; rs11570650; rs5845374; rs11570752; rs4521147; rs11570695; rs11570686; rs34896234; rs132961; rs9622729; rs11570644; rs34944600; rs11570688; rs11570617; rs35195613; rs11570698; rs11913581; rs132981; rs132951; rs12168078; rs11570633; rs11570754; rs5995541; rs11570731; rs132983; rs35205726; rs35928089; rs132942; rs28366733; rs35103228; rs41274545; rs11570738; rs132938; rs10427716; rs11308495; rs35120028; rs132968; rs34478021; rs11570759; rs5845372; rs35606878; rs11570625; rs35795447; rs9607513; rs9622727; rs35440920; rs35948405; rs11570742; rs5995539; rs132947; rs132936; rs36103241; rs5750551; rs11570632; rs35214564; rs35737378; rs132955; rs11570723; rs4610161; rs9622731; rs12165464; rs11570705; rs9622745; rs11570735; rs11570760; rs12484261; rs11570643; rs11570675; rs5756924; rs13054568; rs35788613; rs132957; rs132940; rs34184783; rs5995537; rs5756919; rs11570613; rs11570622; rs11570692; rs36110979; rs11442770; rs11570740; rs132963; rs34379826; rs35337783; rs11570708; rs34566636; rs7290683; rs11570629; rs11570755; rs11570592; rs11570591; rs11570594; rs12167142; rs12167111; rs35918994; rs2142729; rs11570593; rs13054001; rs11570595; rs5756950; rs11570596; rs34482513; rs34112430; rs11089861; rs11570773; rs12484232; rs13055413; rs34184838; rs4296527; rs4820313; rs4821737; rs4821738; rs4821754; rs5756914; rs5756916; rs5995544; rs6001007; rs6001008; rs6001009; rs8140036; rs9306324; rs9622726

# Metabolic_Enzyme_2_General_References:
9417066; 10092647; 10336645; 10591208

# Metabolic_Enzyme_2_References:
10438167; 9135530

# Metabolic_Enzyme_3_ID:
8371

# Metabolic_Enzyme_3_Name:
Multidrug resistance protein 1

# Metabolic_Enzyme_3_Synonyms:
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243 antigen

# Metabolic_Enzyme_3_Gene_Name:
ABCB1

# Metabolic_Enzyme_3_Protein_Sequence:
>Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ

# Metabolic_Enzyme_3_Number_of_Residues:
1280

# Metabolic_Enzyme_3_Molecular_Weight:
141464

# Metabolic_Enzyme_3_Theoretical_pI:
9.44

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_3_General_Function:
Defense mechanisms 

# Metabolic_Enzyme_3_Specific_Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
52-72
120-140
189-209
216-236
297-317
326-346
711-731
757-777
833-853
854-874
937-957
974-994

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.6.3.44

# Metabolic_Enzyme_3_GenBank_ID_Protein:
307180

# Metabolic_Enzyme_3_SwissProt_ID:
MDR1_HUMAN (P08183)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ABCB1

# Metabolic_Enzyme_3_Geneatlas_id:
ABCB1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:40

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>3843 bp
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M14758

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_3_Locus:
7q21.1

# Metabolic_Enzyme_3_SNPs:
rs2032582; rs2229107; rs2229109; rs9282565; rs9282564; rs1202183; rs28364274; rs28401798; rs1045642; rs1128503; rs34748655; rs9282563; rs2235051; rs2235012; rs2188524; rs4728709; rs2214102; rs3213619; rs28381802; rs4148730; rs17149824; rs12720464; rs28364275; rs28381800; rs17328260; rs12536690; rs17328288; rs4148731; rs1978095; rs28381792; rs28381776; rs28381783; rs28381778; rs17328198; rs28381789; rs28381774; rs28364277; rs13233308; rs28381799; rs28381777; rs17149810; rs28381801; rs28364278; rs28381790; rs28381796; rs28381780; rs28381772; rs28381795; rs12668917; rs28381797; rs17064; rs28381787; rs28381781; rs28364279; rs28381771; rs28746504; rs28381779; rs28381773; rs3214119; rs3842; rs28381782; rs12671453; rs28381794; rs11395081; rs28381785; rs2235052; rs4148732; rs28381791; rs28381775; rs17149813; rs28381784; rs2091766; rs1202168; rs1202172; rs1202186; rs1002205; rs1922240; rs1882478; rs1202179; rs1202181; rs2520464; rs2235046; rs2235013; rs1882479; rs1202185; rs4148738; rs2373587; rs4148744; rs6961419; rs2235019; rs1202171; rs7779562; rs10236274; rs10244266; rs4148737; rs4148736; rs10264990; rs3789244; rs1989830; rs4148750; rs10274587; rs956825; rs7787082; rs4148751; rs12539098; rs10268314; rs6952752; rs1186745; rs7787569; rs7795817; rs2235049; rs1202184; rs10248420; rs1202170; rs2235067; rs1202167; rs2141849; rs1202169; rs6949448; rs1202166; rs6961882; rs4148740; rs1202182; rs4437575; rs1211433; rs1882477; rs4148745; rs10225464; rs7802773; rs2235074; rs10276036; rs1922242; rs12704364; rs11975994; rs2235048; rs6961665; rs1922243; rs4148743; rs6980101; rs2235035; rs4148735; rs10260862; rs4148733; rs6950978; rs1016794; rs1202178; rs1202174; rs2032584; rs10256836; rs955000; rs2373588; rs11983225; rs12720066; rs10274441; rs6946379; rs12535512; rs11763872; rs2235033; rs6961417; rs12673269; rs10274623; rs12668877; rs12154941; rs10263741; rs10244116; rs1002204; rs1922241; rs10280101; rs12720067; rs17149754; rs2888599; rs2214104; rs10259849; rs10276603; rs2235018; rs4148742; rs4148739; rs2235026; rs28381837; rs10234411; rs10808072; rs1202175; rs10240953; rs11760837; rs2214103; rs4728702; rs1922244; rs17149738; rs1016793; rs11772987; rs6979885; rs3789243; rs2373586; rs2032583; rs10246696; rs11979702; rs1989831; rs2373589; rs2235027; rs2235040; rs17149792; rs6959435; rs6948766; rs1202176; rs17327624; rs4148749; rs868755; rs10808071; rs17327442; rs4728700; rs4728701; rs6978925; rs1858923; rs17131983; rs17149772; rs2235066; rs3789246; rs28381958; rs28401770; rs1211152; rs28381878; rs28381872; rs4728705; rs2235016; rs28381965; rs2032585; rs4148747; rs28401778; rs28381857; rs2235043; rs28746509; rs7787424; rs28381920; rs28381895; rs2235020; rs2235065; rs28381845; rs13226726; rs28381826; rs28381928; rs16706; rs28381905; rs17149699; rs28401802; rs2235014; rs28381827; rs2235028; rs28381957; rs2235042; rs28401784; rs28381929; rs7804127; rs28401815; rs28381809; rs28401779; rs2235070; rs28381931; rs28381839; rs4148734; rs28381877; rs2235015; rs28381884; rs28381939; rs28381919; rs6971264; rs28381866; rs2235034; rs1202177; rs12334183; rs28401776; rs2235045; rs28381868; rs28381946; rs2235023; rs10280623; rs28381831; rs28401816; rs1186746; rs28381855; rs7804128; rs3028303; rs7787421; rs4728699; rs28401819; rs28381892; rs28401796; rs2214105; rs28381963; rs28381944; rs28381908; rs28381885; rs7802257; rs28381816; rs28401809; rs28381807; rs2235069; rs28401777; rs28381820; rs28381817; rs28381832; rs2373585; rs16885829; rs28381886; rs2235075; rs11304553; rs28401801; rs28381962; rs28381875; rs28381907; rs28381850; rs28401782; rs4148746; rs28381887; rs1186744; rs16885833; rs28364273; rs1024409; rs11769518; rs11761122; rs28381861; rs28381869; rs28381880; rs28381853; rs28381924; rs28746505; rs11972405; rs28401805; rs28401799; rs28381940; rs28746510; rs2235021; rs2235047; rs28381838; rs28381842; rs28381961; rs28381848; rs10249333; rs2032588; rs28381876; rs28381916; rs2235024; rs2235064; rs1989829; rs28401788; rs28381909; rs4728707; rs13239201; rs1211151; rs28381947; rs4728706; rs28401806; rs28381960; rs28381903; rs28401814; rs28381934; rs12704363; rs2188526; rs2235063; rs28401820; rs13229143; rs28381852; rs10225473; rs28381863; rs17327942; rs28381873; rs28364271; rs6970380; rs28381825; rs28381847; rs2235030; rs28381840; rs28381819; rs28381814; rs2235050; rs28381862; rs2188525; rs28401817; rs28381917; rs28401812; rs28401797; rs17149790; rs28381910; rs2235041; rs28381911; rs28401792; rs1209054; rs12154319; rs28381883; rs2235029; rs28364270; rs28401773; rs28381856; rs1202180; rs17327747; rs2032586; rs13237132; rs1202173; rs28401781; rs28381922; rs28381950; rs28381841; rs1055302; rs12539997; rs11984161; rs28381914; rs41309225; rs2707944; rs28381804; rs28381902; rs41315618; rs2032581; rs28381967; rs2235039; rs41305517; rs41316450; rs41309231; rs2235036; rs1128501; rs41309228; rs28381867; rs41304191; rs1128502; rs41311775; rs1128500; rs2235044; rs28381915; rs2707943; rs2235022; rs28381966; rs9332385; rs6977171; rs28381788; rs5014440; rs35770463; rs35644241; rs35267921; rs41296639; rs35012650; rs34081055; rs28655259; rs11294617; rs28364281; rs35855743; rs35453635; rs35447943; rs35141338; rs28381798; rs13242633; rs35260049; rs1468149; rs35477648; rs35998786; rs11440098; rs7794477; rs41297363; rs5885591; rs4604363; rs35132449; rs34962462; rs35268090; rs11342943; rs10275895; rs34208689; rs5014439; rs3926353; rs28381786; rs28381793; rs1966313; rs28364280; rs3926352; rs35998484; rs28381803; rs6952798; rs11440100; rs10275536; rs41297348; rs10600037; rs41278761; rs28381815; rs35600470; rs2706100; rs2235025; rs35471539; rs6971424; rs10252821; rs41297360; rs28381906; rs4728697; rs35757402; rs13230066; rs28401785; rs34947426; rs2706098; rs28381951; rs35227154; rs5014436; rs10600040; rs28381921; rs34445246; rs28381836; rs35818141; rs2235072; rs41308867; rs34775842; rs34289914; rs34776171; rs41297351; rs6980354; rs28381871; rs17149783; rs28401790; rs28381890; rs34445458; rs34628915; rs4148752; rs35639555; rs34885273; rs34598903; rs28381899; rs28549812; rs35711803; rs41316453; rs36015329; rs36218788; rs28401807; rs35335128; rs28381844; rs28381854; rs28381927; rs41309234; rs28381833; rs28401795; rs36097582; rs35513721; rs36008665; rs28381900; rs28381870; rs2373590; rs28746508; rs28381964; rs4148741; rs28381828; rs28381829; rs34298931; rs35280822; rs1922238; rs28381834; rs28381953; rs28401793; rs11440096; rs7457890; rs41309222; rs6952359; rs28381952; rs34609577; rs28381913; rs28401786; rs28381808; rs10273964; rs28381851; rs35981891; rs33959732; rs28381941; rs5014438; rs10237477; rs28381888; rs2235062; rs28381897; rs10532925; rs28381901; rs11974399; rs12720440; rs28381821; rs28746507; rs34127337; rs28381954; rs35440979; rs11768388; rs28681479; rs28401794; rs35766168; rs28381945; rs28381932; rs5014437; rs28381959; rs10244525; rs28381943; rs5885590; rs28401813; rs2706099; rs5885589; rs6973406; rs28381935; rs28381904; rs41297354; rs41297345; rs41316456; rs12720069; rs28401803; rs28381818; rs13245606; rs28381948; rs28746506; rs28381898; rs35334908; rs35070592; rs28381891; rs28381810; rs34923788; rs34332398; rs41296636; rs28381933; rs10600038; rs28381806; rs34657813; rs28401774; rs41296633; rs28381822; rs35498006; rs35572298; rs41274218; rs2235017; rs2235073; rs28401775; rs28381811; rs2235038; rs28381860; rs5885588; rs28381874; rs28381955; rs11322711; rs34291906; rs28381936; rs28381894; rs10661738; rs28371078; rs28401821; rs34614047; rs11348505; rs28381881; rs35522790; rs41296630; rs6150207; rs28381823; rs34986820; rs28381843; rs1212957; rs28401804; rs2235032; rs10600039; rs28401811; rs1922237; rs28401768; rs28381805; rs28364268; rs28401783; rs34532729; rs28401787; rs36119114; rs28401791; rs41304188; rs2235037; rs4727148; rs28381893; rs35635932; rs28401772; rs28381812; rs35238388; rs5885587; rs34517102; rs28381882; rs28381956; rs2373591; rs28401808; rs28381835; rs36218789; rs28381858; rs35259034; rs28381937; rs35687466; rs34513210; rs28381865; rs28401780; rs28381923; rs34325451; rs1882480; rs36125978; rs41278758; rs41309219; rs28401800; rs28381830; rs10240853; rs28381824; rs12720070; rs10274054; rs28718458; rs11771798; rs28381925; rs2235071; rs28381912; rs35881718; rs7809208; rs41297357; rs28401769; rs41304194; rs28381864; rs41296642; rs28401771; rs41315621; rs28381879; rs28381942; rs28381859; rs28364272; rs28381930; rs28381918; rs28381949; rs28381849; rs2706101; rs28381926; rs10713802; rs28401789; rs34766508; rs28381889; rs28364269; rs28381938; rs28381813; rs1202165; rs35820221; rs28401818; rs28381846; rs35396007; rs35583835; rs41312547; rs34127828; rs28381896; rs1055304; rs1055305; rs36074739; rs1015415; rs10231033; rs10232449; rs10233247; rs10246878; rs10254392; rs10261685; rs10264856; rs10267099; rs10275831; rs10276499; rs10278483; rs10486996; rs11973812; rs11975403; rs11983274; rs11983624; rs11984283; rs12538707; rs12539395; rs12540931; rs12670317; rs12672720; rs12704366; rs13221839; rs13231229; rs17149840; rs17149850; rs17149854; rs17149864; rs17149866; rs17209837; rs17250003; rs2028026; rs2157926; rs2157928; rs2157929; rs2188528; rs2188530; rs34398291; rs34767983; rs34800935; rs35633772; rs3747802; rs4148727; rs4148728; rs4263684; rs6465118; rs6951067; rs6952194; rs6957599; rs6963426; rs6968274; rs6969155; rs7455204; rs7786524; rs7790722; rs7790798; rs7796247; rs7799907; rs7802783; rs7810499; rs916715; rs9641019; rs998671

# Metabolic_Enzyme_3_General_References:
2876781; 1967175; 9038218; 12853948; 1972623; 2568832; 11258197; 2897240; 9473242; 10790226; 10716719; 11240981; 11829140

# Metabolic_Enzyme_3_References:
12642476

# Metabolic_Enzyme_4_ID:
7940

# Metabolic_Enzyme_4_Name:
Bile salt-activated lipase precursor

# Metabolic_Enzyme_4_Synonyms:
BAL; Bile salt-stimulated lipase; BSSL; Carboxyl ester lipase; Sterol esterase; Cholesterol esterase; Pancreatic lysophospholipase

# Metabolic_Enzyme_4_Gene_Name:
CEL

# Metabolic_Enzyme_4_Protein_Sequence:
>Bile saltactivated lipase precursor
MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTK
ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPV
MIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPG
NYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQS
GVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYP
MLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT
EEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIA
LAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTV
SKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLR
YWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG
APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP
PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDS
EAAPVPPTDDSKEAQMPAVIRF

# Metabolic_Enzyme_4_Number_of_Residues:
742

# Metabolic_Enzyme_4_Molecular_Weight:
78346

# Metabolic_Enzyme_4_Theoretical_pI:
5.01

# Metabolic_Enzyme_4_GO_Classification:
Not Available

# Metabolic_Enzyme_4_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides

# Metabolic_Enzyme_4_Pathway:
map00120  Bile acid biosynthesis

# Metabolic_Enzyme_4_Reaction:
A steryl ester + H2O = a sterol + a fatty acid

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00135:COesterase

# Metabolic_Enzyme_4_Signals:
1-20

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.3;EC 3.1.1.13

# Metabolic_Enzyme_4_GenBank_ID_Protein:
29501

# Metabolic_Enzyme_4_SwissProt_ID:
CEL_HUMAN (P19835)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CEL

# Metabolic_Enzyme_4_Geneatlas_id:
CEL

# Metabolic_Enzyme_4_hgnc_id:
HGNC:1848

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>2238 bp
ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTG
GCGAGTGCCGCGAAGCTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAAT
AAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT
CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAGGGACCCTGAAGGCC
AAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGAT
GAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAGTCTCCCGGGAC
CTGCCCGTTATGATCTGGATCTATGGAGGCGCCTTCCTCATGGGGTCCGGCCATGGGGCC
AACTTCCTCAACAACTACCTGTATGACGGCGAGGAGATCGCCACACGCGGAAACGTCATC
GTGGTCACCTTCAACTACCGTGTCGGCCCCCTTGGGTTCCTCAGCACTGGGGACGCCAAT
CTGCCAGGTAACTATGGCCTTCGGGATCAGCACATGGCCATTGCTTGGGTGAAGAGGAAT
ATCGCGGCCTTCGGGGGGGACCCCAACAACATCACGCTCTTCGGGGAGTCTGCTGGAGGT
GCCAGCGTCTCTCTGCAGACCCTCTCCCCCTACAACAAGGGCCTCATCCGGCGAGCCATC
AGCCAGAGCGGCGTGGCCCTGAGTCCCTGGGTCATCCAGAAAAACCCACTCTTCTGGGCC
AAAAAGGTGGCTGAGAAGGTGGGTTGCCCTGTGGGTGATGCCGCCAGGATGGCCCAGTGT
CTGAAGGTTACTGATCCCCGAGCCCTGACGCTGGCCTATAAGGTGCCGCTGGCAGGCCTG
GAGTACCCCATGCTGCACTATGTGGGCTTCGTCCCTGTCATTGATGGAGACTTCATCCCC
GCTGACCCGATCAACCTGTACGCCAACGCCGCCGACATCGACTATATAGCAGGCACCAAC
AACATGGACGGCCACATCTTCGCCAGCATCGACATGCCTGCCATCAACAAGGGCAACAAG
AAAGTCACGGAGGAGGACTTCTACAAGCTGGTCAGTGAGTTCACAATCACCAAGGGGCTC
AGAGGCGCCAAGACGACCTTTGATGTCTACACCGAGTCCTGGGCCCAGGACCCATCCCAG
GAGAATAAGAAGAAGACTGTGGTGGACTTTGAGACCGATGTCCTCTTCCTGGTGCCCACC
GAGATTGCCCTAGCCCAGCACAGAGCCAATGCCAAGAGTGCCAAGACCTACGCCTACCTG
TTTTCCCATCCCTCTCGGATGCCCGTCTACCCCAAATGGGTGGGGGCCGACCATGCAGAT
GACATTCAGTACGTTTTCGGGAAGCCCTTCGCCACCCCCACGGGCTACCGGCCCCAAGAC
AGGACAGTCTCTAAGGCCATGATCGCCTACTGGACCAACTTTGCCAAAACAGGGGACCCC
AACATGGGCGACTCGGCTGTGCCCACACACTGGGAACCCTACACTACGGAAAACAGCGGC
TACCTGGAGATCACCAAGAAGATGGGCAGCAGCTCCATGAAGCGGAGCCTGAGAACCAAC
TTCCTGCGCTACTGGACCCTCACCTATCTGGCGCTGCCCACAGTGACCGACCAGGAGGCC
ACCCCTGTGCCCCCCACAGGGGACTCCGAGGCCACTCCCGTGCCCCCCACGGGTGACTCC
GAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGT
GACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCC
ACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTG
CCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGCGCCCCC
CCCGTGCCGCCCACGGGTGACGCCGGGCCCCCCCCCGTGCCGCCCACGGGTGACTCCGGC
GCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGACCCCCACGGGTGAC
TCCGAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCTGTGCCCCCCACG
GGTGACTCTGAGGCTGCCCCTGTGCCCCCCACAGATGACTCCAAGGAAGCTCAGATGCCT
GCAGTCATTAGGTTTTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X54457

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34.3

# Metabolic_Enzyme_4_SNPs:
rs2013751; rs592267; rs8193020; rs657740; rs668809; rs658107; rs657747; rs674908; rs1734945; rs9328542; rs35169970; rs2480920; rs34800980; rs2480922; rs35939167; rs490954; rs657704; rs2480921; rs11552537; rs13287310; rs13283110; rs2480923; rs488087; rs657617; rs35171271; rs2257704; rs598333; rs8193023; rs640509; rs2013695; rs1318508; rs2855061; rs11243990; rs12341761; rs915953; rs35064121; rs2855063; rs2855064; rs2855057; rs2773809; rs12351505; rs11243989; rs2855059; rs36126424; rs11355299; rs8193019; rs7851444; rs644166; rs2855062; rs915950; rs34365056; rs2855056; rs687763; rs34519053; rs34646804; rs11243991; rs2855058; rs640507; rs2855055; rs12344494; rs2855049; rs600825; rs2855066; rs11243988; rs470512; rs2855060; rs2905087; rs2855053; rs12001261; rs2855050; rs12001694; rs674510; rs642440; rs2855054; rs2855052; rs13296252; rs2001000; rs34064957; rs10121942; rs1047780; rs11792806; rs12236821; rs17150138; rs2073821; rs2283134; rs28758507; rs35181097; rs491904; rs509064; rs526855; rs534629; rs563864; rs586977; rs590504; rs607809; rs637435; rs640720; rs645736; rs645841; rs6597598; rs685959; rs7021286; rs7044003; rs7324; rs7852868; rs7863758; rs8193017

# Metabolic_Enzyme_4_General_References:
1698625; 2265692; 1988041; 1639390; 7578248; 1991511; 7654718; 10024660; 11045623

# Metabolic_Enzyme_4_References:
8639615; 9366275

# Metabolic_Enzyme_5_ID:
8348

# Metabolic_Enzyme_5_Name:
Enteropeptidase precursor

# Metabolic_Enzyme_5_Synonyms:
Enterokinase; Serine protease 7[Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]

# Metabolic_Enzyme_5_Gene_Name:
PRSS7

# Metabolic_Enzyme_5_Protein_Sequence:
>Enteropeptidase precursor
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARA
TFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSII
VVFDLFFAQWVSDQNVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNV
SIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQA
THYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETN
PGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDL
NDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEP
ACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFN
AFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSST
NFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPG
PVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVN
LCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLG
LGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQD
ITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAI
LGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEE
NQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYE
EGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH

# Metabolic_Enzyme_5_Number_of_Residues:
1019

# Metabolic_Enzyme_5_Molecular_Weight:
112925

# Metabolic_Enzyme_5_Theoretical_pI:
4.67

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  scavenger receptor activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
Function:  enteropeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases

# Metabolic_Enzyme_5_Pathway:
Not Available

# Metabolic_Enzyme_5_Reaction:
Activation of trypsinogen by selective cleavage of Lys6-|-Ile bond

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00431:CUB;
PF00057:Ldl_recept_a;
PF00629:MAM;
PF01390:SEA;
PF00530:SRCR;
PF00089:Trypsin

# Metabolic_Enzyme_5_Signals:
1-40

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.4.21.9

# Metabolic_Enzyme_5_GenBank_ID_Protein:
746413

# Metabolic_Enzyme_5_SwissProt_ID:
ENTK_HUMAN (P98073)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PRSS7

# Metabolic_Enzyme_5_Geneatlas_id:
PRSS7

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9490

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein (Probable)

# Metabolic_Enzyme_5_Gene_Sequence:
>3060 bp
ATGGGGTCGAAAAGAGGCATATCTTCTAGGCATCATTCTCTCAGCTCCTATGAAATCATG
TTTGCAGCTCTCTTTGCCATATTGGTAGTGCTCTGTGCTGGATTAATTGCAGTATCCTGC
CTGACAATCAAGGAATCCCAACGAGGTGCAGCACTTGGACAGAGTCATGAAGCCAGAGCG
ACATTTAAAATAACATCCGGAGTTACATATAATCCTAATTTGCAAGACAAACTCTCAGTG
GATTTCAAAGTTCTTGCTTTTGACCTTCAGCAAATGATAGATGAGATCTTTCTATCAAGC
AATCTGAAGAATGAATATAAGAACTCAAGAGTTTTACAATTTGAAAATGGCAGCATTATA
GTCGTATTTGACCTTTTCTTTGCCCAGTGGGTGTCAGATCAAAATGTAAAAGAAGAACTG
ATTCAAGGCCTTGAAGCAAATAAATCCAGCCAACTGGTCACTTTCCATATTGATTTGAAC
AGCGTTGATATCCTAGACAAGCTAACAACCACCAGTCATCTGGCAACTCCAGGAAATGTC
TCAATAGAGTGCCTGCCTGGTTCAAGTCCTTGTACTGATGCTCTAACGTGTATAAAAGCT
GATTTATTTTGTGATGGAGAAGTAAACTGTCCAGATGGTTCTGACGAAGACAATAAAATG
TGTGCCACAGTTTGTGATGGAAGATTTTTGTTAACTGGATCATCTGGGTCTTTCCAGGCT
ACTCATTATCCAAAACCTTCTGAAACAAGTGTTGTCTGCCAGTGGATCATACGTGTAAAC
CAAGGACTTTCCATTAAACTGAGCTTCGATGATTTTAATACATATTATACAGATATATTA
GATATTTATGAAGGTGTAGGATCAAGCAAGATTTTAAGAGCTTCTATTTGGGAAACTAAT
CCTGGCACAATAAGAATTTTTTCCAACCAAGTTACTGCCACCTTTCTTATAGAATCTGAT
GAAAGTGATTATGTTGGCTTTAATGCAACATATACTGCATTTAACAGCAGTGAGCTTAAT
AATTATGAGAAAATTAATTGTAACTTTGAGGATGGCTTTTGTTTCTGGGTCCAGGATCTA
AATGATGATAATGAATGGGAAAGGATTCAGGGAAGCACCTTTTCTCCTTTTACTGGACCC
AATTTTGACCACACTTTTGGCAATGCTTCAGGATTTTACATTTCTACCCCAACTGGACCA
GGAGGGAGACAAGAACGAGTGGGGCTTTTAAGCCTCCCTTTGGACCCCACTTTGGAGCCA
GCTTGCCTTAGTTTCTGGTATCATATGTATGGTGAAAATGTCCATAAATTAAGCATTAAT
ATCAGCAATGACCAAAATATGGAGAAGACAGTTTTCCAAAAGGAAGGAAATTATGGAGAC
AATTGGAATTATGGACAAGTAACCCTAAATGAAACAGTTAAATTTAAGGTTGCTTTTAAT
GCTTTTAAAAACAAGATCCTGAGTGATATTGCGTTGGATGACATTAGCCTAACATATGGG
ATTTGCAATGGGAGTCTTTATCCAGAACCAACTTTGGTGCCAACTCCTCCACCAGAACTT
CCTACGGACTGTGGAGGACCTTTTGAGCTGTGGGAGCCAAATACAACATTCAGTTCTACG
AACTTTCCAAACAGCTACCCTAATCTGGCTTTCTGTGTTTGGATTTTAAATGCACAAAAA
GGAAAGAATATACAACTTCATTTTCAAGAATTTGACTTAGAAAATATTAACGATGTAGTT
GAAATAAGAGATGGTGAAGAAGCTGATTCCTTGCTCTTAGCTGTGTACACAGGGCCTGGC
CCAGTAAAGGATGTGTTCTCTACCACCAACAGAATGACTGTGCTTCTCATCACTAACGAT
GTGTTGGCAAGAGGAGGGTTTAAAGCAAACTTTACTACTGGCTATCACTTGGGGATTCCA
GAGCCATGCAAGGCAGACCATTTTCAATGTAAAAATGGAGAGTGTGTTCCACTGGTGAAT
CTCTGTGACGGTCATCTGCACTGTGAGGATGGCTCAGATGAAGCAGATTGTGTGCGTTTT
TTCAATGGCACAACGAACAACAATGGTTTAGTGCGGTTCAGAATCCAGAGCATATGGCAT
ACAGCTTGTGCTGAGAACTGGACCACCCAGATTTCAAATGATGTTTGTCAACTGCTGGGA
CTAGGGAGTGGAAACTCATCAAAGCCAATCTTCTCTACCGATGGTGGACCATTTGTCAAA
TTAAACACAGCACCTGATGGCCACTTAATACTAACACCCAGTCAACAGTGTTTACAGGAT
TCCTTGATTCGGTTACAGTGTAACCATAAATCTTGTGGAAAAAAACTGGCAGCTCAAGAC
ATCACCCCAAAGATTGTTGGAGGAAGTAATGCCAAAGAAGGGGCCTGGCCCTGGGTTGTG
GGTCTGTATTATGGCGGCCGACTGCTCTGCGGCGCATCTCTCGTCAGCAGTGACTGGCTG
GTGTCCGCCGCACACTGCGTGTATGGGAGAAACTTAGAGCCATCCAAGTGGACAGCAATC
CTAGGCCTGCATATGAAATCAAATCTGACCTCTCCTCAAACAGTCCCTCGATTAATAGAT
GAAATTGTCATAAACCCTCATTACAATAGGCGAAGAAAGGACAACGACATTGCCATGATG
CATCTGGAATTTAAAGTGAATTACACAGATTACATACAACCTATTTGTTTACCGGAAGAA
AATCAAGTTTTTCCTCCAGGAAGAAATTGTTCTATTGCTGGTTGGGGGACGGTTGTATAT
CAAGGTACTACTGCAAACATATTGCAAGAAGCTGATGTTCCTCTTCTATCAAATGAGAGA
TGCCAACAGCAGATGCCAGAATATAACATTACTGAAAATATGATATGTGCAGGCTATGAA
GAAGGAGGAATAGATTCTTGTCAGGGGGATTCAGGAGGACCATTAATGTGCCAAGAAAAC
AACAGGTGGTTCCTTGCTGGTGTGACCTCATTTGGATACAAGTGTGCCCTGCCTAATCGC
CCCGGAGTGTATGCCAGGGTCTCAAGGTTTACCGAATGGATACAAAGTTTTCTACATTAG


# Metabolic_Enzyme_5_GenBank_ID_Gene:
U09860

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
rs2824790; rs2824721; rs2824804; rs8134187; rs11088674; rs8130110; rs35987974; rs2273204; rs2824751; rs17698445; rs2027614; rs927; rs9979816; rs7276699; rs2824787; rs1023386; rs2824737; rs2824752; rs2824740; rs2824808; rs2824766; rs2824771; rs2824795; rs2824807; rs2824731; rs1023387; rs1023385; rs2824794; rs2824767; rs1540000; rs2824788; rs1028979; rs2824723; rs2824764; rs2824757; rs2824746; rs2824716; rs2824728; rs2824760; rs719521; rs1041406; rs722682; rs1023388; rs2824724; rs2824738; rs2824765; rs1888409; rs990261; rs2824773; rs2824719; rs2150384; rs2824748; rs2824720; rs2824768; rs2824714; rs1041805; rs2824796; rs2207387; rs2824725; rs2244884; rs2824770; rs1573442; rs2824718; rs2824713; rs2824762; rs1475893; rs7281534; rs2824803; rs2824726; rs2406174; rs1999289; rs2824753; rs4482570; rs6517805; rs2824717; rs2824747; rs724128; rs2824722; rs1155077; rs2824756; rs7277215; rs1474822; rs1023127; rs9984010; rs2824727; rs2824784; rs8130490; rs9978650; rs2824797; rs2824799; rs2824763; rs8131365; rs1474823; rs2824772; rs2824742; rs6517803; rs2824778; rs3787593; rs2824750; rs2824749; rs8130250; rs2210228; rs7275997; rs2144204; rs2824739; rs3787580; rs8132055; rs2824785; rs2824745; rs9305864; rs2824754; rs2824715; rs1888410; rs7283555; rs8131942; rs1079663; rs2824732; rs2824774; rs2824805; rs2824780; rs2210227; rs2824729; rs2824743; rs985824; rs7276303; rs2144205; rs2824761; rs2824733; rs2824776; rs989891; rs974400; rs7277468; rs2824775; rs2824806; rs6517810; rs2824744; rs2824786; rs2824802; rs7283398; rs2824769; rs2824734; rs1474825; rs2207386; rs2824730; rs990214; rs3787590; rs11909148; rs10222071; rs2824800; rs10084582; rs997087; rs2824791; rs985825; rs985326; rs2824781; rs6517809; rs997088; rs11911826; rs4322926; rs2824736; rs7279876; rs990213; rs7282215; rs10084581; rs2824782; rs1023126; rs9977229; rs4143364; rs9305863; rs9982848; rs17771186; rs17781453; rs7280630; rs8133512; rs7283748; rs9983637; rs10482896; rs7277098; rs9980774; rs726489; rs8127494; rs8132226; rs2207385; rs8133003; rs1155847; rs726490; rs2225405; rs8130332; rs9983921; rs8130254; rs7281437; rs8128746; rs1474824; rs2406176; rs7278326; rs7279538; rs12483073; rs11700830; rs1040634; rs8134661; rs2824798; rs11911916; rs11909758; rs10482897; rs9305859; rs2225404; rs2824779; rs8134450; rs2824801; rs7278018; rs9980111; rs2824758; rs6517804; rs2824755; rs11702128; rs9305865; rs3787592; rs2824759; rs985327; rs1040633; rs17699052; rs10084615; rs4452233; rs2824792; rs17836432; rs11911274; rs9974453; rs10222073; rs7283358; rs7279594; rs4507184; rs3787582; rs12627490; rs9978427; rs7283355; rs4395327; rs13046004; rs11908859; rs10222197; rs7281938; rs17781093; rs8127654; rs17002539; rs10222065; rs17002571; rs13050432; rs4557074; rs8126494; rs7281980; rs7281315; rs13047640; rs7276475; rs10222194; rs7279017; rs11702131; rs6517811; rs9305862; rs17002576; rs13050461; rs10084622; rs9983765; rs11702854; rs3787581; rs3859710; rs10222066; rs9305860; rs17002579; rs8130619; rs17002589; rs9982094; rs2824741; rs2210229; rs9982295; rs9981155; rs12482824; rs7277309; rs1970047; rs11702545; rs743379; rs7278155; rs7282891; rs7283015; rs7275641; rs8126615; rs8127480; rs2154691; rs17002545; rs9977711; rs11702698; rs7281295; rs2824777; rs17836380; rs1474821; rs11702334; rs11909781; rs2298406; rs17002585; rs2824783; rs13052606; rs9983373; rs750084; rs11909416; rs9305861; rs9979516; rs9981106; rs17002532; rs10222198; rs17002548; rs9983837; rs8126674; rs6517807; rs2027613; rs2824793; rs10854427; rs2824735; rs7282779; rs2144203; rs12627311; rs17771793; rs17836456; rs8130239; rs10084618; rs17781399; rs2207384; rs7282391; rs7283085; rs7281997; rs11909952; rs8127478; rs17771702; rs9983501; rs9978705; rs997086; rs2027612; rs17836378; rs8126607; rs8128177; rs11088673; rs11910808; rs13047771; rs13052044; rs34543832; rs2051359; rs2824712; rs4312576; rs1569835; rs9975674; rs9979147; rs4493348; rs11088672; rs12626834; rs34162864; rs36047222; rs1005; rs35098038; rs7278479; rs7276084; rs8126887; rs34402555; rs13052987; rs11276239; rs1023384; rs34582893; rs9976107; rs3787583; rs34484160; rs12627091; rs13047058; rs35990835; rs28532285; rs10222190; rs17002592; rs34859334; rs35171230; rs2897386; rs13047487; rs28485981; rs11415439; rs1118289; rs4571147; rs8129347; rs10711798; rs28520584; rs7364052; rs28436100; rs28503505; rs35081352; rs36105980; rs743380; rs11360491; rs35734028; rs12483433; rs35326743; rs28555397; rs13049874; rs5842687; rs17002565; rs9984181; rs10692651; rs36008545; rs2210226; rs2039251; rs35032801; rs35775458; rs34158404; rs3082172; rs13050192; rs10084570; rs28549104; rs35152086; rs34401752; rs3215891; rs10655380; rs10522756; rs8130892; rs28368710; rs9983169; rs7283087; rs3082168; rs34494313; rs9975296; rs35794591; rs10716082; rs34250702; rs11342942; rs28698883; rs34000631; rs9974380; rs11445711; rs8128003; rs34807048; rs35606282; rs28523855; rs17002629; rs9975548; rs34336190; rs28427028; rs28533761; rs28660362; rs28605207; rs35796863; rs5842682; rs35422651; rs34998887; rs9974961; rs8128121; rs4380333; rs8134400; rs11359024; rs9981260; rs34646259; rs34421539; rs7282954; rs13046109; rs34185085; rs8128136; rs35194749; rs5842686; rs10673626; rs8132178; rs11088675; rs7283485; rs17002547; rs4622814; rs13046051; rs35428923; rs3077993; rs28564713; rs33969369; rs13049231; rs13050218; rs7364087; rs35936554; rs4401286; rs10655381; rs28436812; rs10646189; rs13049960; rs35449329; rs10451745; rs35096074; rs7283650; rs9984448; rs4446140; rs9979507; rs3838063; rs10084609; rs8128038; rs9978155; rs35745106; rs41421549; rs11274502; rs35008192; rs10700342; rs34745418; rs34819616; rs9984682; rs7283118; rs34233774; rs6147433; rs12481767; rs9975718; rs9976109; rs7282782; rs12483255; rs28602344; rs5842685; rs35623451; rs8127234; rs5842681; rs13052998; rs17699350; rs34505525; rs9975116; rs33940921; rs10583675; rs4571148; rs34172485; rs10541071; rs35011121; rs11277295; rs13050741; rs3787584; rs11700619; rs35859531; rs34232905; rs997089; rs11415685; rs9983629; rs13050848; rs34897835; rs8132001; rs34703253; rs7275275; rs34859096; rs34924498; rs28637313; rs5842679; rs10854426; rs35050572; rs28438747; rs34851604; rs735587; rs34897917; rs34428802; rs8135009; rs9979832; rs10154181; rs9978711; rs34787707; rs34738152; rs10531849; rs34006357; rs5842683; rs9982987; rs10544329; rs34888947; rs35909926; rs28691719; rs7283705; rs13049006; rs13047279; rs3077991; rs3077967; rs8133660; rs35493450; rs13049075; rs9941891; rs11353083; rs11360557; rs34737434; rs34084673; rs11357306; rs10701453; rs35335139; rs3859709; rs35459605; rs28713519; rs34247769; rs35449998; rs13048566; rs5842680; rs35075011; rs11438174; rs9979312; rs12626940; rs28473094; rs35986295; rs34089904; rs2406175; rs10537881; rs13047621; rs4578944; rs35329978; rs8127878; rs35990274; rs7282946; rs34073617; rs3991146; rs3077964; rs3077965; rs34733991; rs1034317; rs35493306; rs35893025; rs34942696; rs35820113; rs34824949; rs35184231; rs1051520; rs1051526; rs1051530; rs11088671; rs11909235; rs11909352; rs11909449; rs11911895; rs11911907; rs12627551; rs2051357; rs2051358; rs2180022; rs2210231; rs2252042; rs2300513; rs2300514; rs2824809; rs2824810; rs2824811; rs34172611; rs36042528; rs3827160; rs3920685; rs4381857; rs7276893; rs8130195; rs8132893; rs9979144; rs9980992; rs9984371

# Metabolic_Enzyme_5_General_References:
7718557; 11719902; 10830953; 8052624

# Metabolic_Enzyme_5_References:
7479669

# Metabolic_Enzyme_6_ID:
8278

# Metabolic_Enzyme_6_Name:
Ectonucleoside triphosphate diphosphohydrolase 2

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
ENTPD2

# Metabolic_Enzyme_6_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 2
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPA
DKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLG
ATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENF
IKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSF
LCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVS
LSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMG
LPVATLQQLEAAAVNVCNQTWAQQLLSRGYGFDERAFGGVIFQKKAADTAVGWALGYMLN
LTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALVLLLRQVHSAKLPSTI

# Metabolic_Enzyme_6_Number_of_Residues:
472

# Metabolic_Enzyme_6_Molecular_Weight:
51162

# Metabolic_Enzyme_6_Theoretical_pI:
8.10

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Not Available

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Not Available

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
7-29; 438-460

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.6.1.3

# Metabolic_Enzyme_6_GenBank_ID_Protein:
55962657

# Metabolic_Enzyme_6_SwissProt_ID:
Q5SPY6_HUMAN (Q5SPY6)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ENTPD2

# Metabolic_Enzyme_6_Geneatlas_id:
ENTPD2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:3364

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_6_Gene_Sequence:
>1419 bp
ATGGCCGGGAAGGTGCGGTCACTGCTGCCGCCGCTGCTGCTGGCCGCCGCGGGCCTCGCC
GGCCTCCTACTGCTGTGCGTCCCCACCCGCGACGTCCGGGAGCCGCCCGCCCTCAAGTAT
GGCATCGTCCTGGACGCTGGTTCTTCACACACGTCCATGTTTATCTACAAGTGGCCGGCA
GACAAGGAGAACGACACAGGCATTGTGGGCCAGCACAGCTCCTGTGATGTTCCAGGTGGG
GGCATCTCCAGCTATGCAGACAACCCTTCTGGGGCCAGCCAGAGTCTTGTTGGATGCCTC
GAACAGGCGCTTCAGGATGTGCCCAAAGAGAGACACGCGGGCACACCCCTCTACCTGGGA
GCCACAGCGGGTATGCGCCTGCTCAACCTGACCAATCCAGAGGCCTCGACCAGTGTGCTC
ATGGCAGTGACTCACACACTGACCCAGTACCCCTTTGACTTCCGGGGTGCACGCATCCTC
TCGGGCCAGGAAGAGGGGGTGTTTGGCTGGGTGACTGCCAACTACCTGCTGGAGAACTTC
ATCAAGTACGGCTGGGTGGGCCGGTGGTTCCGGCCACGGAAGGGGACACTGGGGGCCATG
GACCTGGGGGGTGCCTCTACCCAGATCACTTTTGAGACAACCAGTCCAGCTGAGGACAGA
GCCAGCGAGGTCCAGCTGCATCTCTACGGCCAGCACTACCGAGTCTACACCCACAGCTTC
CTCTGCTATGGCCGTGACCAGGTCCTCCAGAGGCTGCTGGCCAGCGCCCTCCAGACCCAC
GGCTTCCACCCCTGCTGGCCGAGGGGCTTTTCCACCCAAGTGCTGCTCGGGGATGTGTAC
CAGTCACCATGCACCATGGCCCAGCGGCCCCAGAACTTCAACAGCAGTGCCAGGGTCAGC
CTGTCAGGGAGCAGTGACCCCCACCTCTGCCGAGATCTGGTTTCTGGGCTCTTCAGCTTC
TCCTCCTGCCCCTTCTCCCGATGCTCTTTCAATGGGGTCTTCCAGCCCCCAGTGGCTGGG
AACTTTGTGGCCTTCTCTGCCTTCTTCTACACTGTGGACTTTTTGCGGACTTCGATGGGG
CTGCCCGTGGCCACCCTGCAGCAGCTGGAGGCAGCCGCAGTGAATGTCTGCAACCAGACC
TGGGCTCAGCAGCTGCTGAGTCGCGGCTACGGCTTCGACGAGCGCGCCTTCGGCGGCGTG
ATCTTCCAGAAGAAGGCCGCGGACACTGCAGTGGGCTGGGCGCTCGGCTACATGCTGAAC
CTGACCAACCTGATCCCCGCCGACCCGCCGGGGCTGCGCAAGGGCACAGACTTCAGCTCC
TGGGTCGTCCTCCTGCTGCTCTTCGCCTCCGCGCTCCTGGCTGCGCTTGTCCTGCTGCTG
CGTCAGGTGCACTCCGCCAAGCTGCCAAGCACCATTTAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AL807752

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_6_Locus:
9q34

# Metabolic_Enzyme_6_SNPs:
rs34618694; rs7873815; rs4880083; rs2292925; rs7861020; rs11145979; rs7390981; rs7024097; rs12005251; rs12555382; rs10735661; rs7848899; rs10870170; rs7869777; rs12004425; rs11145977; rs12005729; rs7860436; rs7869655; rs11145976; rs3763661; rs12551623; rs7390933; rs3763662; rs35983961; rs11539737; rs17853460; rs2271866; rs17853461; rs35674457; rs7041887; rs33994273; rs28545468; rs2271867; rs12004426; rs12554236; rs34679600; rs10870169; rs34657628; rs4880084; rs2292924; rs7869520; rs5023370; rs1568352; rs34616561; rs13292220; rs5023369; rs34429443; rs11788719; rs9411242; rs34832424; rs3750514; rs10781534; rs11145975; rs11145980; rs13289619; rs35547344; rs3750517; rs3763663; rs3814504; rs3829107; rs4273935; rs4880085; rs6605; rs7026504; rs7038280; rs7388830; rs9411299

# Metabolic_Enzyme_6_General_References:
Not Available

# Metabolic_Enzyme_6_References:
8106499

# Macromolecular_Interacting_Partner_1_ID:
7519

# Macromolecular_Interacting_Partner_1_Name:
Canalicular multispecific organic anion transporter 2

# Macromolecular_Interacting_Partner_1_Synonyms:
ATP-binding cassette sub-family C member 3; Multidrug resistance-associated protein 3; Multi-specific organic anion transporter-D; MOAT-D

# Macromolecular_Interacting_Partner_1_Gene_Name:
ABCC3

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Canalicular multispecific organic anion transporter 2
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
VAEFDSPANLIAARGIFYGMARDAGLA

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
1527

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
169345

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.20

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_1_Specific_Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
33-53
74-94
100-120
133-153
172-192
303-323
350-370
427-447
451-471
534-554
577-597
964-984
1022-1042
1086-1106
1108-1128
1200-1220
1223-1243

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3132270

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
MRP3_HUMAN (O15438)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ABCC3

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ABCC3

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:54

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>4584 bp
ATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCT
GTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGAACTCCCTGCTGGCCTGGGTG
CCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGT
CGTGGCTACATCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTG
TGGTGCGTCTCCTGGGCAGACCTTTTTTACTCCTTCCATGGCCTGGTCCATGGCCGGGCC
CCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACC
CTGCTGATACAGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTC
TGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCTCCAAGATCCTTTTAGCCAAG
GCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTG
GTACTCTCTGCCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAG
AATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCTTTCTCTCCCGCCTGTTTTTC
TGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTC
TGGTCCCTAAAGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGG
AGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAGCAGCACCTGGGAAAAATGCC
TCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTG
AAGGCCCTGCTGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATC
CAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCATCCTGATCAGGTTTATCTCC
AACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCC
ATGATGCAGTCGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAG
TTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTCTGGTTATCACCAACTCAGTC
AAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTC
ATGGACCTTGCCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCG
ATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGGCTGGAGTCGCTTTCATGGTC
TTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAA
ATGAAATTGAAGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTG
CTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGGTGGAGGGCATCAGGCAGGGT
GAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATG
TGCAGCCCCTTCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAAC
AATGTGCTGGACGCCGAGAAGGCCTATGTGTCTGTGTCCTTGTTTAATATCTTAAGACTT
CCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAA
CGGATCCAGCAATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACC
ATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCTTCACCTGGGCCCAGGACCTG
CCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTG
GGGCCTGTGGGCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAG
CTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATGTGCCCCAGCAGGCATGGATC
CAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTAC
CAGCAGACTCTGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGAT
CAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGGGCCAGCGGCAGCGGGTCAGT
CTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCG
GTGGACTCTCATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTG
GCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCTTCCTGCCCCAGACAGACTTC
ATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAG
CGCAACGGCTCCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCAC
CTGGAGGACAGCTGGACCGCGTTGGAAGGTGCAGAGGATAAGGAGGCACTGCTGATTGAA
GACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAG
AAGCAGTTTATGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCT
GTACCCCGGAGGCACCTGGGTCCATCAGAGAAGGTGCAGGTGACAGAGGCGAAGGCAGAT
GGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGG
GATTATGCCAAGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGT
CAAAGTGCGGCTGCCATTGGAGCCAATGTGTGGCTCAGTGCCTGGACAAATGATGCCATG
GCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATT
CTGCAAGGGTTCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCT
GCCCGTGTGTTGCACCAGGCACTGCTGCACAACAAGATACGCTCGCCACAGTCCTTCTTT
GACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGAT
GAGGTTCTGGCCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACT
CTTGTGGTCATCATGGCCAGCACGCCGCTCTTCACTGTGGTCATCCTGCCCCTGGCTGTG
CTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAA
TCAGTCAGCCGCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTC
ATCCGGGCCTACAACCGCAGCCGGGATTTTGAGATCATCAGTGATACTAAGGTGGATGCC
AACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAG
TTCGTGGGGAACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGC
CTGAACCCGGGGCTGGTGGGCCTTTCTGTGTCCTACTCCTTGCAGGTGACATTTGCTCTG
AACTGGATGATACGAATGATGTCAGATTTGGAATCTAACATCGTGGCTGTGGAGAGGGTC
AAGGAGTACTCCAAGACAGAGACAGAGGCGCCCTGGGTGGTGGAAGGCAGCCGCCCTCCC
GAAGGTTGGCCCCCACGTGGGGAGGTGGAGTTCCGGAATTATTCTGTGCGCTACCGGCCG
GGCCTAGACCTGGTGCTGAGAGACCTGAGTCTGCATGTGCATGGTGGCGAGAAGGTGGGG
ATCGTGGGCCGCACTGGGGCTGGCAAGTCTTCCATGACCCTTTGCCTGTTCCGCATCCTG
GAGGCGGCAAAGGGTGAAATCCGCATTGATGGCCTCAATGTGGCAGACATCGGCCTCCAT
GACCTGCGCTCTCAGCTGACCATCATCCCGCAGGACCCCATCCTGTTCTCGGGGACCCTG
CGCATGAACCTGGACCCCTTCGGCAGCTACTCAGAGGAGGACATTTGGTGGGCTTTGGAG
CTGTCCCACCTGCACACGTTTGTGAGCTCCCAGCCGGCAGGCCTGGACTTCCAGTGCTCA
GAGGGCGGGGAGAATCTCAGCGTGGGCCAGAGGCAGCTCGTGTGCCTGGCCCGAGCCCTG
CTCCGCAAGAGCCGCATCCTGGTTTTAGACGAGGCCACAGCTGCCATCGACCTGGAGACT
GACAACCTCATCCAGGCTACCATCCGCACCCAGTTTGATACCTGCACTGTCCTGACCATC
GCACACCGGCTTAACACTATCATGGACTACACCAGGGTCCTGGTCCTGGACAAAGGAGTA
GTAGCTGAGTTTGATTCTCCAGCCAACCTCATTGCAGCTAGAGGCATCTTCTACGGGATG
GCCAGAGATGCTGGACTTGCCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB010887

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_1_Locus:
17q22

# Macromolecular_Interacting_Partner_1_SNPs:
rs11568591; rs4148416; rs2277624; rs1051640; rs11568589; rs872793; rs11568607; rs8075406; rs3785911; rs2240802; rs12451302; rs2301837; rs8077268; rs967935; rs2412333; rs739923; rs4148413; rs1548529; rs4148412; rs1978153; rs4148415; rs739921; rs11651958; rs16949207; rs4794173; rs3785912; rs739922; rs8076674; rs4148411; rs2107438; rs733392; rs1541391; rs2301836; rs879459; rs12051822; rs2240801; rs886493; rs2072366; rs7216383; rs4148405; rs8079432; rs9902630; rs17562516; rs886492; rs16949205; rs1541392; rs1558287; rs11870374; rs3785913; rs9905584; rs8070592; rs12451964; rs4794178; rs17562467; rs9893660; rs740786; rs7215354; rs9303560; rs11654404; rs7218932; rs11658264; rs9892309; rs16949202; rs4148409; rs11079922; rs719717; rs4793666; rs4794174; rs1137449; rs733393; rs17642714; rs11869371; rs8079556; rs10153257; rs2015146; rs3826434; rs11870410; rs11869370; rs12604031; rs4794175; rs9894568; rs12603393; rs11869632; rs1989983; rs4793665; rs9895420; rs17563146; rs1003355; rs11656685; rs1003354; rs1051625; rs11549764; rs41280128; rs41280126; rs28470592; rs28586870; rs34221557; rs12450249; rs35364174; rs9896793; rs1989283; rs12103933; rs1558288; rs875238; rs3892688; rs1989226; rs7224093; rs5024133; rs34201788; rs35824469; rs12103817; rs12943812; rs4638630; rs4794176; rs10714203; rs4148414; rs4794177; rs12940921; rs8082610; rs2066763; rs4148407; rs34847172; rs12946653; rs10608553; rs28489929; rs35452921; rs4148408; rs11653384; rs34582346; rs35792889; rs11300167; rs35231927; rs1974609; rs2023907; rs34498638; rs35977569; rs9891029; rs8064807; rs35369910; rs11079921; rs732760; rs34856648; rs9890046; rs35128486; rs34564586; rs3063105; rs35538577; rs34556513; rs3216955; rs12946683; rs36088946; rs12452686; rs4148410; rs35481482; rs28581563; rs7224691; rs5024132; rs35968768; rs35516930; rs4793667; rs35957356; rs9891165; rs4423464; rs35147050; rs12944018; rs5024134; rs2072365; rs4423465; rs11654892; rs35507460; rs34858494; rs3063107; rs7222959; rs34956109; rs35623528; rs5820828; rs5024131; rs1974608; rs4148403; rs35467079; rs34183195; rs10491146; rs11568580; rs11568582; rs11568583; rs11568584; rs11568586; rs11568587; rs11568588; rs11568590; rs11568595; rs11568596; rs11568597; rs11568598; rs11568599; rs11568600; rs11568602; rs11568604; rs11568606; rs11568608; rs11867598; rs12602161; rs14882; rs17717246; rs2107441; rs2107442; rs2189595; rs2214566; rs2286650; rs2412332; rs3180373; rs34675700; rs34958340; rs35999272; rs3815378; rs4148418; rs7212045; rs739925; rs757420; rs757421; rs8073706; rs8075158; rs8081077; rs8196; rs9455; rs9893223; rs9901250; rs9910012; rs9911750

# Macromolecular_Interacting_Partner_1_General_References:
9738950; 10094960; 9813153; 9889399; 9827529; 9270026

# Macromolecular_Interacting_Partner_1_References:
10987286; 12763363

# Macromolecular_Interacting_Partner_2_ID:
7531

# Macromolecular_Interacting_Partner_2_Name:
Bile salt export pump

# Macromolecular_Interacting_Partner_2_Synonyms:
ATP-binding cassette sub-family B member 11

# Macromolecular_Interacting_Partner_2_Gene_Name:
ABCB11

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Bile salt export pump
MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW
LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN
QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR
RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK
LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE
VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLV
QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI
EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT
VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF
IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV
LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG
NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST
YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL
GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML
GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL
SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI
EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV
ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF
VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID
GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF
VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA
LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI
S

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
1321

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
146395

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
63-83
148-168
216-236
241-261
320-340
354-374
756-776
795-815
870-890
891-911
980-1000
1012-1032

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
3873243

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
ABCBB_HUMAN (O95342)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ABCB11

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ABCB11

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:42

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>3966 bp
ATGTCTGACTCAGTAATTCTTCGAAGTATAAAGAAATTTGGAGAGGAGAATGATGGTTTT
GAGTCAGATAAATCATATAATAATGATAAGAAATCAAGGTTACAAGATGAGAAGAAAGGT
GATGGCGTTAGAGTTGGCTTCTTTCAATTGTTTCGGTTTTCTTCATCAACTGACATTTGG
CTGATGTTTGTGGGAAGTTTGTGTGCATTTCTCCATGGAATAGCCCAGCCAGGCGTGCTA
CTCATTTTTGGCACAATGACAGATGTTTTTATTGACTACGACGTTGAGTTACAAGAACTC
CAGATTCCAGGAAAAGCATGTGTGAATAACACCATTGTATGGACTAACAGTTCCCTCAAC
CAGAACATGACAAATGGAACACGTTGTGGGTTGCTGAACATCGAGAGCGAAATGATCAAA
TTTGCCAGTTACTATGCTGGAATTGCTGTCGCAGTACTTATCACAGGATATATTCAAATA
TGCTTTTGGGTCATTGCCGCAGCTCGTCAGATACAGAAAATGAGAAAATTTTACTTTAGG
AGAATAATGAGAATGGAAATAGGGTGGTTTGACTGCAATTCAGTGGGGGAGCTGAATACA
AGATTCTCTGATGATATTAATAAAATCAATGATGCCATAGCTGACCAAATGGCCCTTTTC
ATTCAGCGCATGACCTCGACCATCTGTGGTTTCCTGTTGGGATTTTTCAGGGGTTGGAAA
CTGACCTTGGTTATTATTTCTGTCAGCCCTCTCATTGGGATTGGAGCAGCCACCATTGGT
CTGAGTGTGTCCAAGTTTACGGACTATGAGCTGAAGGCCTATGCCAAAGCAGGGGTGGTG
GCTGATGAAGTCATTTCATCAATGAGAACAGTGGCTGCTTTTGGTGGTGAGAAAAGAGAG
GTTGAAAGGTATGAGAAAAATCTTGTGTTCGCCCAGCGTTGGGGAATTAGAAAAGGAATA
GTGATGGGATTCTTTACTGGATTCGTGTGGTGTCTCATCTTTTTGTGTTATGCAGTGGCC
TTCTGGTACGGCTCCACACTTGTCCTGGATGAAGGAGAATATACACCAGGAACCCTTGTC
CAGATTTTCCTCAGTGTCATAGTAGGAGCTTTAAATCTTGGCAATGCCTCTCCTTGTTTG
GAAGCCTTTGCAACTGGACGTGCAGCAGCCACCAGCATTTTTGAGACAATAGACAGGAAA
CCCATCATTGACTGCATGTCAGAAGATGGTTACAAGTTGGATCGAATCAAGGGTGAAATT
GAATTCCATAATGTGACCTTCCATTATCCTTCCAGACCAGAGGTGAAGATTCTAAATGAC
CTCAACATGGTCATTAAACCAGGGGAAATGACAGCTCTGGTAGGACCCAGTGGAGCTGGA
AAAAGTACAGCACTGCAACTCATTCAGCGATTCTATGACCCCTGTGAAGGAATGGTGACC
GTGGATGGCCATGACATTCGCTCTCTTAACATTCAGTGGCTTAGAGATCAGATTGGGATA
GTGGAGCAAGAGCCAGTTCTGTTCTCTACCACCATTGCAGAAAATATTCGCTATGGCAGA
GAAGATGCAACAATGGAAGACATAGTCCAAGCTGCCAAGGAGGCCAATGCCTACAACTTC
ATCATGGACCTGCCACAGCAATTTGACACCCTTGTTGGAGAAGGAGGAGGCCAGATGAGT
GGTGGCCAGAAACAAAGGGTAGCTATCGCCAGAGCCCTCATCCGAAATCCCAAGATTCTG
CTTTTGGACATGGCCACCTCAGCTCTGGACAATGAGAGTGAAGCCATGGTGCAAGAAGTG
CTGAGTAAGATTCAGCATGGGCACACAATCATTTCAGTTGCTCATCGCTTGTCTACGGTC
AGAGCTGCAGATACCATCATTGGTTTTGAACATGGCACTGCAGTGGAAAGAGGGACCCAT
GAAGAATTACTGGAAAGGAAAGGTGTTTACTTCACTCTAGTGACTTTGCAAAGCCAGGGA
AATCAAGCTCTTAATGAAGAGGACATAAAGGATGCAACTGAAGATGACATGCTTGCGAGG
ACCTTTAGCAGAGGGAGCTACCAGGATAGTTTAAGGGCTTCCATCCGGCAACGCTCCAAG
TCTCAGCTTTCTTACCTGGTGCACGAACCTCCATTAGCTGTTGTAGATCATAAGTCTACC
TATGAAGAAGATAGAAAGGACAAGGACATTCCTGTGCAGGAAGAAGTTGAACCTGCCCCA
GTTAGGAGGATTCTGAAATTCAGTGCTCCAGAATGGCCCTACATGCTGGTAGGGTCTGTG
GGTGCAGCTGTGAACGGGACAGTCACACCCTTGTATGCCTTTTTATTCAGCCAGATTCTT
GGGACTTTTTCAATTCCTGATAAAGAGGAACAAAGGTCACAGATCAATGGTGTGTGCCTA
CTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTT
GCTAAATCTGGGGAGCTCCTAACAAAAAGGCTACGTAAATTTGGTTTCAGGGCAATGCTG
GGGCAAGATATTGCCTGGTTTGATGACCTCAGAAATAGCCCTGGAGCATTGACAACAAGA
CTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTC
AATTCCTTCACTAACGTCACTGTGGCCATGATCATTGCCTTCTCCTTTAGCTGGAAGCTG
AGCCTGGTCATCTTGTGCTTCTTCCCCTTCTTGGCTTTATCAGGAGCCACACAGACCAGG
ATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACA
AATGAAGCCCTCAGTAACATCCGCACTGTTGCTGGAATTGGAAAGGAGAGGCGGTTCATT
GAAGCACTTGAGACTGAGCTGGAGAAGCCCTTCAAGACAGCCATTCAGAAAGCCAATATT
TACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTAC
AGATATGGAGGTTACTTAATCTCCAATGAGGGGCTCCATTTCAGCTATGTGTTCAGGGTG
ATCTCTGCAGTTGTACTGAGTGCAACAGCTCTTGGAAGAGCCTTCTCTTACACCCCAAGT
TATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCA
ATCAGTGTATACAATACTGCAGGTGAAAAATGGGACAACTTCCAGGGGAAGATTGATTTT
GTTGATTGTAAATTTACATATCCTTCTCGACCTGACTCGCAAGTTCTGAATGGTCTCTCA
GTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGC
ACTAGCATTCAGCTGTTGGAACGTTTCTATGATCCTGATCAAGGGAAGGTGATGATAGAT
GGTCATGACAGCAAAAAAGTAAATGTCCAGTTCCTCCGCTCAAACATTGGAATTGTTTCC
CAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACC
AAAGAAATTCCCATGGAAAGAGTCATAGCAGCTGCAAAACAGGCTCAGCTGCATGATTTT
GTCATGTCACTCCCAGAGAAATATGAAACTAACGTTGGGTCCCAGGGGTCTCAACTCTCT
AGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTG
CTACTAGATGAAGCCACTTCTGCCTTAGACACAGAAAGTGAAAAGACGGTGCAGGTTGCT
CTAGACAAAGCCAGAGAGGGTCGGACCTGCATTGTCATTGCCCATCGCTTGTCCACCATC
CAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCAT
GAAGAACTGATGGCCCAAAAAGGAGCCTACTACAAACTAGTCACCACTGGATCCCCCATC
AGTTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AF091582

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q24

# Macromolecular_Interacting_Partner_2_SNPs:
rs11568357; rs2287622; rs2287617; rs1521808; rs11568361; rs7563233; rs11568377; rs497692; rs2287616; rs11568365; rs3815675; rs34200464; rs11568362; rs4148777; rs4148768; rs7578587; rs3770602; rs11892966; rs7602171; rs473351; rs495714; rs13416851; rs13430236; rs496550; rs11892650; rs12614405; rs12612685; rs12617788; rs13387523; rs3770603; rs4148772; rs10172523; rs34104195; rs35372131; rs11902424; rs12611596; rs13403581; rs3732038; rs13429894; rs4668115; rs13393726; rs4148770; rs10208125; rs494874; rs519887; rs853789; rs862662; rs853783; rs2685814; rs503931; rs853787; rs575671; rs2287618; rs555975; rs566879; rs3770582; rs13407866; rs484066; rs7602485; rs519035; rs3755157; rs10199694; rs2685805; rs6759871; rs11892887; rs6751546; rs853780; rs2241339; rs853772; rs6433100; rs853774; rs485094; rs7602204; rs10208831; rs13403911; rs6761690; rs3821120; rs853778; rs6709087; rs10192504; rs6433102; rs6733156; rs10170513; rs2241342; rs2058996; rs6759156; rs853785; rs10172795; rs3770599; rs13416802; rs2544360; rs1101531; rs486981; rs4148776; rs483234; rs508506; rs10179758; rs853788; rs3770593; rs551754; rs2287621; rs3770591; rs3755158; rs4148782; rs4148791; rs4148790; rs3897807; rs3770594; rs853773; rs2287613; rs4148783; rs2287615; rs6736455; rs508743; rs10208608; rs853775; rs3770592; rs567074; rs17267869; rs10211329; rs6433096; rs13404027; rs16856247; rs7605199; rs3770596; rs860510; rs2389610; rs2241341; rs853779; rs13403982; rs13400716; rs2389615; rs10176934; rs3770601; rs579060; rs6758316; rs2287614; rs12692889; rs10199881; rs4148784; rs11887272; rs7561903; rs853786; rs3770597; rs13432949; rs579275; rs6751775; rs4148793; rs11568378; rs4148798; rs853791; rs13404014; rs479682; rs3815676; rs569805; rs1402836; rs11902627; rs2241340; rs3770598; rs3770588; rs13384680; rs4140386; rs16856256; rs2892806; rs11901443; rs1101533; rs4148785; rs1581397; rs2287623; rs2389604; rs4148797; rs13404242; rs17540154; rs10188208; rs480562; rs16823014; rs552976; rs4148794; rs3755160; rs853784; rs853776; rs3770590; rs3770589; rs16856300; rs7560402; rs4148778; rs12613034; rs853781; rs569829; rs3770585; rs10184113; rs2389603; rs3770595; rs2287619; rs12621591; rs10200158; rs2193831; rs12618846; rs472614; rs10175055; rs6709971; rs16856258; rs13413844; rs10202842; rs10164496; rs10196984; rs4142230; rs7572878; rs10202892; rs2685810; rs34313070; rs3770587; rs2389605; rs10176901; rs16856332; rs9287908; rs12622271; rs10177080; rs7425273; rs10209995; rs2216503; rs2389608; rs35472607; rs2685811; rs7568243; rs35442846; rs6713587; rs2263243; rs11899077; rs16856314; rs13414957; rs10184334; rs2216502; rs10184421; rs11901379; rs3815677; rs2544367; rs7607790; rs3821121; rs7586497; rs9287906; rs11901292; rs2287620; rs2685812; rs10196426; rs2389607; rs3770583; rs11890609; rs16856261; rs11884980; rs853777; rs2685803; rs12477292; rs7566645; rs565412; rs2389611; rs16856327; rs4148780; rs36011224; rs11903009; rs508741; rs853782; rs35440743; rs11900829; rs34113235; rs2250677; rs2389609; rs2685813; rs7576531; rs13419622; rs3821122; rs4148773; rs34882395; rs3770584; rs10177015; rs2287612; rs2307959; rs864929; rs10208702; rs35178517; rs3836043; rs2389606; rs7570800; rs17267730; rs9287907; rs4148775; rs34532548; rs10206511; rs10167993; rs865528; rs16856252; rs10206671; rs4140387; rs2685807; rs10174358; rs13404228; rs531772; rs10200453; rs7558863; rs4148779; rs2216504; rs3829888; rs478333; rs557462; rs4148765; rs3814381; rs10930343; rs4148804; rs16856392; rs2947987; rs2241338; rs3814382; rs41265143; rs3755161; rs34782741; rs13390147; rs13397300; rs35236376; rs13425780; rs3834150; rs3755162; rs3836045; rs4148767; rs10198321; rs4148771; rs3755163; rs35322731; rs3770571; rs5836218; rs11393553; rs35314698; rs10178577; rs13015444; rs13390715; rs10181388; rs5836212; rs13382331; rs6724525; rs34998320; rs34497610; rs2544362; rs28556624; rs7419342; rs13395480; rs10579127; rs12990578; rs34477999; rs33988336; rs2893113; rs10184673; rs34210697; rs3836044; rs4148795; rs28719023; rs2893112; rs3770600; rs35384412; rs2272063; rs36089386; rs4142231; rs34130824; rs2632379; rs3770586; rs5836215; rs35728285; rs34539397; rs10168672; rs34376889; rs3084001; rs2685808; rs11898632; rs2193832; rs34307604; rs10533402; rs2632377; rs2544364; rs35351007; rs4148802; rs2544359; rs35908291; rs7566984; rs10687976; rs3841893; rs2389613; rs4148799; rs28810810; rs35201800; rs35103099; rs4148787; rs10636147; rs10533400; rs34849968; rs36121242; rs1101534; rs13393626; rs35174354; rs34526705; rs35501527; rs35362717; rs2544361; rs13428002; rs13389076; rs4667589; rs35120985; rs482508; rs10168323; rs7603227; rs11896548; rs10524072; rs2390792; rs35460880; rs12996841; rs853790; rs12996022; rs11302722; rs10533403; rs5836214; rs7605296; rs34135220; rs17268587; rs35101041; rs2389612; rs28374129; rs2544363; rs35051200; rs11356690; rs34760671; rs13410784; rs10624627; rs2685804; rs35964117; rs7580720; rs13420697; rs4148774; rs28689500; rs13389921; rs4148803; rs34285735; rs13404044; rs35592488; rs35297422; rs4148781; rs11457018; rs4668110; rs3898462; rs34483735; rs28578897; rs34627998; rs35279237; rs34996265; rs35960929; rs12463887; rs2544366; rs10533404; rs4148800; rs34287805; rs35050126; rs12477616; rs35127857; rs28735569; rs12989783; rs10637568; rs4148792; rs35973488; rs34781398; rs10690488; rs13390485; rs3770580; rs13383759; rs2892807; rs10699842; rs4148789; rs4000815; rs35032329; rs4408693; rs2685806; rs33998212; rs34589831; rs34691362; rs13004789; rs3084035; rs7606165; rs35154196; rs7570477; rs34059765; rs35977549; rs527150; rs10681889; rs34080185; rs35552243; rs35580713; rs35340526; rs5836217; rs10554578; rs4516393; rs2544365; rs34311278; rs10168093; rs35514442; rs36001889; rs3214428; rs4668113; rs2632378; rs2632371; rs34453330; rs35194008; rs13019923; rs13033087; rs34138939; rs13410266; rs28405534; rs35658999; rs35059993; rs4148786; rs11890781; rs34193789; rs35929467; rs28802954; rs35849398; rs13425860; rs36026125; rs4148796; rs28727965; rs28846465; rs13407637; rs28864721; rs3083997; rs35270920; rs35439431; rs10168165; rs17208900; rs10533401; rs2892808; rs34166812; rs1101532; rs3814383; rs13407824; rs35500066; rs35992163; rs34090697; rs34874425; rs34616346; rs10184740; rs10490134; rs10490135; rs10497346; rs10497347; rs11568356; rs11568358; rs11568359; rs11568360; rs11568363; rs11568364; rs11568366; rs11568371; rs11568373; rs11568374; rs11568376; rs11568379; rs11892211; rs11902639; rs12615867; rs13385351; rs13391933; rs13394065; rs13400268; rs13407094; rs13410081; rs13419326; rs1357170; rs16856185; rs16856187; rs16856196; rs16856207; rs16856209; rs16856406; rs2161037; rs2177075; rs2544368; rs2632376; rs4144857; rs4144858; rs4233823; rs475612; rs502570; rs504979; rs537183; rs563694; rs6433097; rs7577650

# Macromolecular_Interacting_Partner_2_General_References:
9806540; 11829140; 11815775

# Macromolecular_Interacting_Partner_2_References:
11179459; 11264982; 11557132; 12404239

# Macromolecular_Interacting_Partner_3_ID:
7546

# Macromolecular_Interacting_Partner_3_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
PRL

# Macromolecular_Interacting_Partner_3_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_3_Signals:
1-28

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_3_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_3_References:
11564677; 7945260

# Macromolecular_Interacting_Partner_4_ID:
7193

# Macromolecular_Interacting_Partner_4_Name:
Glucagon precursor [Contains: Glicentin; Glicentin-related polypeptide

# Macromolecular_Interacting_Partner_4_Synonyms:
GRPP; Oxyntomodulin; OXY; OXM; Glucagon; Glucagon-like peptide 1; GLP-1; Glucagon-like peptide 1(7-37; GLP-1(7-37; Glucagon-like peptide 1(7-36; GLP-1(7-36; Glucagon-like peptide 2; GLP-2]

# Macromolecular_Interacting_Partner_4_Gene_Name:
GCG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Glucagon precursor Contains: Glicentin; Glicentinrelated polypeptide
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTS
DYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFI
AWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK


# Macromolecular_Interacting_Partner_4_Number_of_Residues:
180

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
20909

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.14

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_4_Signals:
1-20

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
183270

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
GLUC_HUMAN (P01275)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
GCG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
GCG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:4191

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>543 bp
ATGAAAAGCATTTACTTTGTGGCTGGGTTATTTGTAATGCTGGTACAAGGCAGCTGGCAA
CGTTCCCTTCAAGACACAGAGGAGAAATCCAGATCATTCTCAGCTTCCCAGGCAGACCCA
CTCAGTGATCCTGATCAGATGAACGAGGACAAGCGCCATTCACAGGGCACATTCACCAGT
GACTACAGCAAGTATCTGGACTCCAGGCGTGCCCAAGATTTTGTGCAGTGGTTGATGAAT
ACCAAGAGGAACAGGAATAACATTGCCAAACGTCACGATGAATTTGAGAGACATGCTGAA
GGGACCTTTACCAGTGATGTAAGTTCTTATTTGGAAGGCCAAGCTGCCAAGGAATTCATT
GCTTGGCTGGTGAAAGGCCGAGGAAGGCGAGATTTCCCAGAAGAGGTCGCCATTGTTGAA
GAACTTGGCCGCAGACATGCTGATGGTTCTTTCTCTGATGAGATGAACACCATTCTTGAT
AATCTTGCCGCCAGGGACTTTATAAACTGGTTGATTCAGACCAAAATCACTGACAGGAAA
TAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
J04040

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2q36-q37

# Macromolecular_Interacting_Partner_4_SNPs:
rs5645; rs4664448; rs6732914; rs4664449; rs10490424; rs10164435; rs11897425; rs7581952; rs7569992; rs7559086; rs5649; rs4664447; rs5653; rs6727317; rs13306377; rs5647; rs5654; rs13306376; rs1990761; rs6717659; rs13001107; rs16846320; rs13416088; rs35424779; rs6717263; rs3811540; rs6717609; rs35328019; rs5650; rs11552334; rs35920035; rs11552338; rs1042405; rs11552330; rs11552335; rs34074912; rs11552339; rs17711059; rs11552332; rs16846334; rs11552331; rs11552336; rs35185096; rs35902561; rs35301560; rs10557377; rs10603613; rs5648; rs34801095; rs10671204; rs33949193; rs5652; rs5646; rs11378120; rs7569999; rs34405490; rs5651; rs11898004; rs35323923; rs13429709; rs10696486; rs34204135; rs35205044; rs3811539; rs7590067; rs11692314; rs17762054; rs41368446; rs34932341; rs10170813; rs10189636; rs11888030; rs13010545; rs13028221; rs2111487; rs2193494; rs2216338; rs2389680; rs2389681; rs3761656; rs4664450; rs6704722; rs6733736; rs7599142

# Macromolecular_Interacting_Partner_4_General_References:
2901414; 3725587; 6877358; 2753890; 8482423; 14557443; 14632334; 9287128; 12651102; 12554744; 12626323; 10605628; 9667960; 11943215; 12627948

# Macromolecular_Interacting_Partner_4_References:
15377289; 9724030

# Macromolecular_Interacting_Partner_5_ID:
7551

# Macromolecular_Interacting_Partner_5_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_5_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_5_References:
10613737

# Macromolecular_Interacting_Partner_6_ID:
7556

# Macromolecular_Interacting_Partner_6_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_6_Signals:
1-18

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_6_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_6_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_6_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_6_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_6_References:
11546646; 11682480; 8166281

# Macromolecular_Interacting_Partner_7_ID:
6198

# Macromolecular_Interacting_Partner_7_Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase

# Macromolecular_Interacting_Partner_7_Synonyms:
HMG-CoA reductase

# Macromolecular_Interacting_Partner_7_Gene_Name:
HMGCR

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>3hydroxy3methylglutarylcoenzyme A reductase
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
888

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
97477

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.72

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  hydroxymethylglutaryl-CoA reductase (NADPH) activity
 ||
>>>
Process:  primary metabolism
Process:  lipid metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  organelle membrane
Component:  endoplasmic reticulum membrane
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis

# Macromolecular_Interacting_Partner_7_Pathway:
map00100  Biosynthesis of steroids

# Macromolecular_Interacting_Partner_7_Reaction:
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00368:HMG-CoA_red

# Macromolecular_Interacting_Partner_7_Signals:
1-23

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 1.1.1.34

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
306865

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
HMDH_HUMAN (P04035)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
HMGCR

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
HMGCR

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5006

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; multi-pass membrane protein. Peroxisome; peroxisomal membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>2667 bp
ATGTTGTCAAGACTTTTTCGAATGCATGGCCTCTTTGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACACTGACCATCTGCATGATGTCCATGAACATGTTTACTGGTAAC
AATAAGATCTGTGGTTGGAATTATGAATGTCCAAAGTTTGAAGAGGATGTTTTGAGCAGT
GACATTATAATTCTGACAATAACACGATGCATAGCCATCCTGTATATTTACTTCCAGTTC
CAGAATTTACGTCAACTTGGATCAAAATATATTTTGGGTATTGCTGGCCTTTTCACAATT
TTCTCAAGTTTTGTATTCAGTACAGTTGTCATTCACTTCTTAGACAAAGAATTGACAGGC
TTGAATGAAGCTTTGCCCTTTTTCCTACTTTTGATTGACCTTTCCAGAGCAAGCACATTA
GCAAAGTTTGCCCTCAGTTCCAACTCACAGGATGAAGTAAGGGAAAATATTGCTCGTGGA
ATGGCAATTTTAGGTCCTACGTTTACCCTCGATGCTCTTGTTGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTACGTCAGCTTGAAATTATGTGCTGCTTTGGCTGCATGTCA
GTTCTTGCCAACTACTTCGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTATTA
GAGCTTTCTCGGGAAAGCCGCGAGGGTCGTCCAATTTGGCAGCTCAGCCATTTTGCCCGA
GTTTTAGAAGAAGAAGAAAATAAGCCGAATCCTGTAACTCAGAGGGTCAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCATGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGTACAGCAGATACTTCTAAGGTTTCATTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCAAGTGTTTCCCTCTGGCAGTTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAACAGAGACAGAATCTACACTCTCATTAAAAAACCCTATCACATCTCCTGTAGTGACA
CAAAAGAAAGTCCCAGACAATTGTTGTAGACGTGAACCTATGCTGGTCAGAAATAACCAG
AAATGTGATTCAGTAGAGGAAGAGACAGGGATAAACCGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTAGTGGCTGAAACAGATACCCCAAACAGAGCTACATTTGTGGTTGGTAACTCC
TCCTTACTCGATACTTCATCAGTACTGGTGACACAGGAACCTGAAATTGAACTTCCCAGG
GAACCTCGGCCTAATGAAGAATGTCTACAGATACTTGGGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTAGTCAATGCTAAGCATATCCCAGCCTACAAG
TTGGAAACTCTGATGGAAACTCATGAGCGTGGTGTATCTATTCGCCGACAGTTACTTTCC
AAGAAGCTTTCAGAACCTTCTTCTCTCCAGTACCTACCTTACAGGGATTATAATTACTCC
TTGGTGATGGGAGCTTGTTGTGAGAATGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCCCTTTGCTTAGATGAAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGT
TGTCTTGTGGCCAGCACCAATAGAGGCTGCAGAGCAATAGGTCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGATGGGATGACTCGTGGCCCAGTTGTGCGTCTTCCACGTGCTTGT
GACTCTGCAGAAGTGAAAGCCTGGCTCGAAACATCTGAAGGGTTCGCAGTGATAAAGGAG
GCATTTGACAGCACTAGCAGATTTGCACGTCTACAGAAACTTCATACAAGTATAGCTGGA
CGCAACCTTTATATCCGTTTCCAGTCCAGGTCAGGGGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTTTCAAAACTTCACGAGTATTTCCCTGAAATGCAGATT
CTAGCCGTTAGTGGTAACTATTGTACTGACAAGAAACCTGCTGCTATAAATTGGATAGAG
GGAAGAGGAAAATCTGTTGTTTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACCACAGAGGCTATGATTGAGGTCAACATTAACAAGAATTTAGTGGGCTCT
GCCATGGCTGGGAGCATAGGAGGCTACAACGCCCATGCAGCAAACATTGTCACCGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCAAACTGTATTACTTTA
ATGGAAGCAAGTGGTCCCACAAATGAAGATTTATATATCAGCTGCACCATGCCATCTATA
GAGATAGGAACGGTGGGTGGTGGGACCAACCTACTACCTCAGCAAGCCTGTTTGCAGATG
CTAGGTGTTCAAGGAGCATGCAAAGATAATCCTGGGGAAAATGCCCGGCAGCTTGCCCGA
ATTGTGTGTGGGACCGTAATGGCTGGGGAATTGTCACTTATGGCAGCATTGGCAGCAGGA
CATCTTGTCAAAAGTCACATGATTCACAACAGGTCGAAGATCAATTTACAAGACCTCCAA
GGAGCTTGCACCAAGAAGACAGCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M11058

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_7_Locus:
5q13.3-q14

# Macromolecular_Interacting_Partner_7_SNPs:
rs5908; rs10038095; rs12916; rs10045497; rs5909; rs17883498; rs17244932; rs17238554; rs17238379; rs17244771; rs17238372; rs17244764; rs17238393; rs17244757; rs17244743; rs17244778; rs6805; rs10474435; rs2241402; rs2878419; rs3846662; rs3846661; rs10942735; rs3846663; rs6453131; rs6882842; rs17244855; rs12654264; rs7717396; rs17244841; rs17244806; rs17238596; rs17238540; rs17244862; rs10473972; rs10474434; rs17244890; rs11742194; rs10515198; rs17238477; rs17244848; rs17244883; rs17238449; rs17244834; rs2303152; rs17244813; rs17238484; rs3064877; rs11957984; rs10053643; rs17238435; rs2303151; rs17238456; rs17238603; rs35767444; rs17238575; rs17238589; rs17244897; rs17244827; rs10063134; rs35635349; rs3843482; rs17238519; rs17238498; rs17244792; rs17244799; rs17244960; rs17244785; rs17238442; rs17244876; rs4629571; rs3761739; rs17244953; rs17238337; rs17238330; rs17244708; rs3761738; rs3761740; rs17244946; rs17244715; rs34652146; rs34334938; rs35436905; rs35561739; rs36010179; rs1044453; rs11402730; rs35855355; rs34198674; rs11453557; rs12657545; rs35306582; rs10683134; rs11379632; rs17648121; rs33988510; rs11443896; rs10590407; rs2898551; rs3064191; rs35744174; rs35152895; rs35491024; rs33926107; rs13436857; rs11743717; rs11749783; rs11957619; rs16872521; rs16872523; rs3180743; rs35176659; rs3733907; rs3761741; rs3843480; rs3843481; rs3931914; rs4703670; rs4704209; rs7703051

# Macromolecular_Interacting_Partner_7_General_References:
2991281; 10698924; 10391209

# Macromolecular_Interacting_Partner_7_References:
7835596; 7843727; 7986821; 8612995

# Macromolecular_Interacting_Partner_8_ID:
7569

# Macromolecular_Interacting_Partner_8_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_8_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_8_Signals:
1-29

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_8_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_8_Locus:
7p21

# Macromolecular_Interacting_Partner_8_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_8_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_8_References:
10947163; 7810656

# Macromolecular_Interacting_Partner_9_ID:
7574

# Macromolecular_Interacting_Partner_9_Name:
Cholecystokinins precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
CCK[Contains: Cholecystokinin 58; CCK58; Cholecystokinin 39; CCK39; Cholecystokinin 33; CCK33; Cholecystokinin 12; CCK12; Cholecystokinin 8; CCK8]

# Macromolecular_Interacting_Partner_9_Gene_Name:
CCK

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Cholecystokinins precursor
MNSGVCLCVLMAVLAAGALTQPVPPADPAGSGLQRAEEAPRRQLRVSQRTDGESRAHLGA
LLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
12670

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.22

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00918:Gastrin

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
179996

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
CCKN_HUMAN (P06307)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
CCK

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
CCK

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:1569

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>348 bp
ATGAACAGCGGCGTGTGCCTGTGCGTGCTGATGGCGGTACTGGCGGCTGGCGCCCTGACG
CAGCCGGTGCCTCCCGCAGATCCCGCGGGCTCCGGGCTGCAGCGGGCAGAGGAGGCGCCC
CGTAGGCAGCTGAGGGTATCGCAGAGAACGGATGGCGAGTCCCGAGCGCACCTGGGCGCC
CTGCTGGCAAGATACATCCAGCAGGCCCGGAAAGCTCCTTCTGGACGAATGTCCATCGTT
AAGAACCTGCAGAACCTGGACCCCAGCCACAGGATAAGTGACCGGGACTACATGGGCTGG
ATGGATTTTGGCCGTCGCAGTGCCGAGGAGTATGAGTACCCCTCCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
L00354

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_9_Locus:
3p22-p21.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs3774395; rs754635; rs747456; rs1799923; rs747455; rs8192473; rs2241996; rs6784327; rs6762874; rs11571844; rs2241997; rs11571876; rs11571846; rs11571843; rs11571847; rs1868522; rs4377469; rs8192472; rs10865918; rs2278794; rs4602358; rs11129949; rs11571857; rs11571855; rs11571851; rs3774396; rs11571864; rs11571866; rs11571863; rs11571875; rs7616571; rs11571867; rs11571871; rs11571856; rs11571849; rs11571853; rs10865917; rs11129948; rs11571877; rs11571888; rs11571878; rs11571842; rs11571884; rs11571887; rs11571882; rs11571880; rs11571841; rs3806691; rs11571838; rs11571879; rs11571848; rs11559016; rs1050815; rs11571845; rs3774394; rs11328368; rs4634088; rs34621311; rs11571859; rs11298401; rs11345711; rs11571873; rs11571862; rs4266164; rs11571865; rs11571852; rs11571860; rs11571858; rs11571872; rs11571869; rs11571854; rs11571874; rs11571861; rs35155419; rs7371919; rs11571870; rs11571868; rs11571881; rs11571886; rs34853186; rs11571839; rs11571840; rs11571883; rs35292864; rs11571885; rs10460960; rs11129946; rs11129947; rs11129950; rs12493571; rs13069836; rs17071699; rs17071704; rs17071771; rs1867020; rs1868520; rs1868521; rs2029127; rs4450782; rs4488805; rs4533619; rs6605331; rs6786615; rs7615049; rs7621531; rs7628785; rs7628795; rs9311317; rs935111; rs935112; rs9682785; rs9757702; rs9813346; rs9835027

# Macromolecular_Interacting_Partner_9_General_References:
3856870; 11076522

# Macromolecular_Interacting_Partner_9_References:
7678329; 9013282; 9712181

# Macromolecular_Interacting_Partner_10_ID:
7592

# Macromolecular_Interacting_Partner_10_Name:
Secretin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
SCT

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Secretin precursor
MAPRPLLLLLLLLGGSAARPAPPRARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQ
DAENSMAWTRLSAGLLCPSGSNMPILQAWMPLDGTWSPWLPPGPMVSEPAGAAAEGTLRP
R

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
121

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
13016

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
11.78

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00123:Hormone_2

# Macromolecular_Interacting_Partner_10_Signals:
1-18

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
11138667

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
SECR_HUMAN (P09683)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SCT

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SCT

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:10607

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>366 bp
ATGGCCCCCCGGCCCCTCCTGCTGCTGCTGCTGCTCCTCGGGGGCTCCGCCGCGCGCCCC
GCGCCCCCCAGGGCCCGGCGACACTCAGACGGGACGTTCACCAGCGAGCTCAGCCGCCTG
CGGGAGGGCGCGCGGCTCCAGCGGCTGCTACAGGGCCTGGTGGGGAAGCGCAGCGAGCAG
GACGCAGAGAACAGCATGGCCTGGACCAGGCTCAGCGCGGGTCTGCTCTGCCCGTCAGGG
TCCAACATGCCCATCCTGCAGGCCTGGATGCCCCTGGACGGGACCTGGTCTCCCTGGCTG
CCCCCTGGGCCTATGGTTTCAGAACCAGCTGGCGCTGCTGCAGAAGGAACCTTGCGGCCC
AGATGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF244355

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_10_Locus:
11p15.5

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
11060443

# Macromolecular_Interacting_Partner_10_References:
12360484; 16440368

# Macromolecular_Interacting_Partner_11_ID:
5331

# Macromolecular_Interacting_Partner_11_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_11_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_11_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_11_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_11_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_11_Signals:
1-19

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_11_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_11_Locus:
2q37

# Macromolecular_Interacting_Partner_11_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_11_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_11_References:
7488238; 7560859; 8099310

# Macromolecular_Interacting_Partner_12_ID:
5749

# Macromolecular_Interacting_Partner_12_Name:
Cytochrome P450 7A1

# Macromolecular_Interacting_Partner_12_Synonyms:
Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase

# Macromolecular_Interacting_Partner_12_Gene_Name:
CYP7A1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Cytochrome P450 7A1
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCK
LMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDG
NTTENINDTFIKTLQGHALNS
LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV
MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK
QFDKVFPALVAGLPIHMFRTAHNAREK
LAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHL
VVLWASQANTIPATFW
SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII
KESLR
LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE
NGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQA
KCPPLDQSRAGLGILP
PLNDIEFKYKFKHL

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
504

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
57661

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.34

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_12_Specific_Function:
Cholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O

# Macromolecular_Interacting_Partner_12_Pathway:
map00120  Bile acid biosynthesis

# Macromolecular_Interacting_Partner_12_Reaction:
cholesterol + NADPH + H+ + O2 = 7alpha-hydroxycholesterol + NADP+ + H2O

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_12_Signals:
1-23

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
EC 1.14.13.17

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
23909

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CP7A1_HUMAN (P22680)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CYP7A1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CYP7A1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2651

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1515 bp

ATGATGACCACATCTTTGATTTGGGGGATTGCTATAGCAGCATGCTGTTGTCTATGGCT
TATTCTTGGAA
TTAGGAGAAGGCAAACGGGTGAACCACCTCTAGAGAATGGATTAATTC
CATACCTGGGCTGTGCTCTGCA
ATTTGGTGCCAATCCTCTTGAGTTCCTCAGAGCAAAT
CAAAGGAAACATGGTCATGTTTTTACCTGCAAA
CTAATGGGAAAATATGTCCATTTCAT
CACAAATCCCTTGTCATACCATAAGGTGTTGTGCCACGGAAAAT
ATTTTGATTGGAAAA
AATTTCACTTTGCTACTTCTGCGAAGGCATTTGGGCACAGAAGCATTGACCCGAT
GGAT
GGAAATACCACTGAAAACATAAACGACACTTTCATCAAAACCCTGCAGGGCCATGCCTTG
AATTCC
CTCACGGAAAGCATGATGGAAAACCTCCAACGTATCATGAGACCTCCAGTCTC
CTCTAACTCAAAGACCG
CTGCCTGGGTGACAGAAGGGATGTATTCTTTCTGCTACCGAG
TGATGTTTGAAGCTGGGTATTTAACTAT
CTTTGGCAGAGATCTTACAAGGCGGGACACA
CAGAAAGCACATATTCTAAACAATCTTGACAACTTCAAG
CAATTCGACAAAGTCTTTCC
AGCCCTGGTAGCAGGCCTCCCCATTCACATGTTCAGGACTGCGCACAATG
CCCGGGAGA
AACTGGCAGAGAGCTTGAGGCACGAGAACCTCCAAAAGAGGGAAAGCATCTCAGAACTGA
T
CAGCCTGCGCATGTTTCTCAATGACACTTTGTCCACCTTTGATGATCTGGAGAAGGCC
AAGACACACCTC
GTGGTCCTCTGGGCATCGCAAGCAAACACCATTCCAGCGACTTTCTG
GAGTTTATTTCAAATGATTAGGA
ACCCAGAAGCAATGAAAGCAGCTACTGAAGAAGTGA
AAAGAACATTAGAGAATGCTGGTCAAAAAGTCAG
CTTGGAAGGCAATCCTATTTGTTTG
AGTCAAGCAGAACTGAATGACCTGCCAGTATTAAATAGTATAATC
AAGGAATCGCTGAG
GCTTTCCAGTGCCTCCCTCAACATCCGGACAGCTAAGGAGGATTTCACTTTGCACC
TTG
AGGACGGTTCCTACAACATCCGAAAAGATAGCATCATAGCTCTTTACCCACAGTTAATGC
ACTTAGA
TCCAGAAATCTACCCAGACCCTTTGACTTTTAAATATGATAGGTATCTTGAT
GAAAACGGGAAGACAAAG
ACTACCTTCTATTGTAATGGACTCAAGTTAAAGTATTACTA
CATGCCCTTTGGATCGGGAGCTACAATAT
GTCCTGGAAGATTGTTCGCTATCCACGAAA
TCAAGCAATTTTTGATTCTGATGCTTTCTTATTTTGAATT
GGAGCTTATAGAGGGCCAA
GCTAAATGTCCACCTTTGGACCAGTCCCGGGCAGGCTTGGGCATTTTGCCG
CCATTGAA
TGATATTGAATTTAAATATAAATTCAAGCATTTGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
X56088

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Locus:
Not Available

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
8439551; 2384150; 1610352; 8020987; 1312351; 12721789

# Macromolecular_Interacting_Partner_12_References:
7666012; 7735245; 7835596; 7843727

# Macromolecular_Interacting_Partner_13_ID:
6988

# Macromolecular_Interacting_Partner_13_Name:
Canalicular multispecific organic anion transporter 1

# Macromolecular_Interacting_Partner_13_Synonyms:
ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2; Canalicular multidrug resistance protein

# Macromolecular_Interacting_Partner_13_Gene_Name:
ABCC2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Canalicular multispecific organic anion transporter 1
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSS
TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS
RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI
FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS
KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG
TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG
YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET
VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL
STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS
QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI
SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD
IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL
FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD
IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV
EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS
ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG
KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR
DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI
VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF
YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW
ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS
EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII
PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG
QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD
SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
1545

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
174194

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.46

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  transporter activity
Function:  ATPase activity
Function:  hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Function:  ATPase activity, coupled to transmembrane movement of substances
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Defense mechanisms 

# Macromolecular_Interacting_Partner_13_Specific_Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00664:ABC_membrane;
PF00005:ABC_tran

# Macromolecular_Interacting_Partner_13_Signals:
None

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
28-48
69-89
94-114
127-147
166-186
314-334
361-381
438-458
462-482
545-565
588-608
972-992
1034-1054
1098-1118
1120-1140
1212-1232
1235-1255

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
1764162

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
MRP2_HUMAN (Q92887)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
ABCC2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
ABCC2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:53

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>4638 bp
ATGCTGGAGAAGTTCTGCAACTCTACTTTTTGGAATTCCTCATTCCTGGACAGTCCGGAG
GCAGACCTGCCACTTTGTTTTGAGCAAACTGTTCTGGTGTGGATTCCCTTGGGCTTCCTA
TGGCTCCTGGCCCCCTGGCAGCTTCTCCACGTGTATAAATCCAGGACCAAGAGATCCTCT
ACCACCAAACTCTATCTTGCTAAGCAGGTATTCGTTGGTTTTCTTCTTATTCTAGCAGCC
ATAGAGCTGGCCCTTGTACTCACAGAAGACTCTGGACAAGCCACAGTCCCTGCTGTTCGA
TATACCAATCCAAGCCTCTACCTAGGCACATGGCTCCTGGTTTTGCTGATCCAATACAGC
AGACAATGGTGTGTACAGAAAAACTCCTGGTTCCTGTCCCTATTCTGGATTCTCTCGATA
CTCTGTGGCACTTTCCAATTTCAGACTCTGATCCGGACACTCTTACAGGGTGACAATTCT
AATCTAGCCTACTCCTGCCTGTTCTTCATCTCCTACGGATTCCAGATCCTGATCCTGATC
TTTTCAGCATTTTCAGAAAATAATGAGTCATCAAATAATCCATCATCCATAGCTTCATTC
CTGAGTAGCATTACCTACAGCTGGTATGACAGCATCATTCTGAAAGGCTACAAGCGTCCT
CTGACACTCGAGGATGTCTGGGAAGTTGATGAAGAGATGAAAACCAAGACATTAGTGAGC
AAGTTTGAAACGCACATGAAGAGAGAGCTGCAGAAAGCCAGGCGGGCACTCCAGAGACGG
CAGGAGAAGAGCTCCCAGCAGAACTCTGGAGCCAGGCTGCCTGGCTTGAACAAGAATCAG
AGTCAAAGCCAAGATGCCCTTGTCCTGGAAGATGTTGAAAAGAAAAAAAAGAAGTCTGGG
ACCAAAAAAGATGTTCCAAAATCCTGGTTGATGAAGGCTCTGTTCAAAACTTTCTACATG
GTGCTCCTGAAATCATTCCTACTGAAGCTAGTGAATGACATCTTCACGTTTGTGAGTCCT
CAGCTGCTGAAATTGCTGATCTCCTTTGCAAGTGACCGTGACACATATTTGTGGATTGGA
TATCTCTGTGCAATCCTCTTATTCACTGCGGCTCTCATTCAGTCTTTCTGCCTTCAGTGT
TATTTCCAACTGTGCTTCAAGCTGGGTGTAAAAGTACGGACAGCTATCATGGCTTCTGTA
TATAAGAAGGCATTGACCCTATCCAACTTGGCCAGGAAGGAGTACACCGTTGGAGAAACA
GTGAACCTGATGTCTGTGGATGCCCAGAAGCTCATGGATGTGACCAACTTCATGCACATG
CTGTGGTCAAGTGTTCTACAGATTGTCTTATCTATCTTCTTCCTATGGAGAGAGTTGGGA
CCCTCAGTCTTAGCAGGTGTTGGGGTGATGGTGCTTGTAATCCCAATTAATGCGATACTG
TCCACCAAGAGTAAGACCATTCAGGTCAAAAATATGAAGAATAAAGACAAACGTTTAAAG
ATCATGAATGAGATTCTTAGTGGAATCAAGATCCTGAAATATTTTGCCTGGGAACCTTCA
TTCAGAGACCAAGTACAAAACCTCCGGAAGAAAGAGCTCAAGAACCTGCTGGCCTTTAGT
CAACTACAGTGTGTAGTAATATTCGTCTTCCAGTTAACTCCAGTCCTGGTATCTGTGGTC
ACATTTTCTGTTTATGTCCTGGTGGATAGCAACAATATTTTGGATGCACAAAAGGCCTTC
ACCTCCATTACCCTCTTCAATATCCTGCGCTTTCCCCTGAGCATGCTTCCCATGATGATC
TCCTCCATGCTCCAGGCCAGTGTTTCCACAGAGCGGCTAGAGAAGTACTTGGGAGGGGAT
GACTTGGACACATCTGCCATTCGACATGACTGCAATTTTGACAAAGCCATGCAGTTTTCT
GAGGCCTCCTTTACCTGGGAACATGATTCGGAAGCCACAGTCCGAGATGTGAACCTGGAC
ATTATGGCAGGCCAACTTGTGGCTGTGATAGGCCCTGTCGGCTCTGGGAAATCCTCCTTG
ATATCAGCCATGCTGGGAGAAATGGAAAATGTCCACGGGCACATCACCATCAAGGGCACC
ACTGCCTATGTCCCACAGCAGTCCTGGATTCAGAATGGCACCATAAAGGACAACATCCTT
TTTGGAACAGAGTTTAATGAAAAGAGGTACCAGCAAGTACTGGAGGCCTGTGCTCTCCTC
CCAGACTTGGAAATGCTGCCTGGAGGAGATTTGGCTGAGATTGGAGAGAAGGGTATAAAT
CTTAGTGGGGGTCAGAAGCAGCGGATCAGCCTGGCCAGAGCTACCTACCAAAATTTAGAC
ATCTATCTTCTAGATGACCCCCTGTCTGCAGTGGATGCTCATGTAGGAAAACATATTTTT
AATAAGGTCTTGGGCCCCAATGGCCTGTTGAAAGGCAAGACTCGACTCTTGGTTACACAT
AGCATGCACTTTCTTCCTCAAGTGGATGAGATTGTAGTTCTGGGGAATGGAACAATTGTA
GAGAAAGGATCCTACAGTGCTCTCCTGGCCAAAAAAGGAGAGTTTGCTAAGAATCTGAAG
ACATTTCTAAGACATACAGGCCCTGAAGAGGAAGCCACAGTCCATGATGGCAGTGAAGAA
GAAGACGATGACTATGGGCTGATATCCAGTGTGGAAGAGATCCCCGAAGATGCAGCCTCC
ATAACCATGAGAAGAGAGAACAGCTTTCGTCGAACACTTAGCCGCAGTTCTAGGTCCAAT
GGCAGGCATCTGAAGTCCCTGAGAAACTCCTTGAAAACTCGGAATGTGAATAGCCTGAAG
GAAGACGAAGAACTAGTGAAAGGACAAAAACTAATTAAGAAGGAATTCATAGAAACTGGA
AAGGTGAAGTTCTCCATCTACCTGGAGTACCTACAAGCAATAGGATTGTTTTCGATATTC
TTCATCATCCTTGCGTTTGTGATGAATTCTGTGGCTTTTATTGGATCCAACCTCTGGCTC
AGTGCTTGGACCAGTGACTCTAAAATCTTCAATAGCACCGACTATCCAGCATCTCAGAGG
GACATGAGAGTTGGAGTCTACGGAGCTCTGGGATTAGCCCAAGGTATATTTGTGTTCATA
GCACATTTCTGGAGTGCCTTTGGTTTCGTCCATGCATCAAATATCTTGCACAAGCAACTG
CTGAACAATATCCTTCGAGCACCTATGAGATTTTTTGACACAACACCCACAGGCCGGATT
GTGAACAGGTTTGCCGGCGATATTTCCACAGTGGATGACACCCTGCCTCAGTCCTTGCGC
AGCTGGATTACATGCTTCCTGGGGATAATCAGCACCCTTGTCATGATCTGCATGGCCACT
CCTGTCTTCACCATCATCGTCATTCCTCTTGGCATTATTTATGTATCTGTTCAGATGTTT
TATGTGTCTACCTCCCGCCAGCTGAGGCGTCTGGACTCTGTCACCAGGTCCCCAATCTAC
TCTCACTTCAGCGAGACCGTATCAGGTTTGCCAGTTATCCGTGCCTTTGAGCACCAGCAG
CGATTTCTGAAACACAATGAGGTGAGGATTGACACCAACCAGAAATGTGTCTTTTCCTGG
ATCACCTCCAACAGGTGGCTTGCAATTCGCCTGGAGCTGGTTGGGAACCTGACTGTCTTC
TTTTCAGCCTTGATGATGGTTATTTATAGAGATACCCTAAGTGGGGACACTGTTGGCTTT
GTTCTGTCCAATGCACTCAATATCACACAAACCCTGAACTGGCTGGTGAGGATGACATCA
GAAATAGAGACCAACATTGTGGCTGTTGAGCGAATAACTGAGTACACAAAAGTGGAAAAT
GAGGCACCCTGGGTGACTGATAAGAGGCCTCCGCCAGATTGGCCCAGCAAAGGCAAGATC
CAGTTTAACAACTACCAAGTGCGGTACCGACCTGAGCTGGATCTGGTCCTCAGAGGGATC
ACTTGTGACATCGGTAGCATGGAGAAGATTGGTGTGGTGGGCAGGACAGGAGCTGGAAAG
TCATCCCTCACAAACTGCCTCTTCAGAATCTTAGAGGCTGCCGGTGGTCAGATTATCATT
GATGGAGTAGATATTGCTTCCATTGGGCTCCACGACCTCCGAGAGAAGCTGACCATCATC
CCCCAGGACCCCATCCTGTTCTCTGGAAGCCTGAGGATGAATCTCGACCCTTTCAACAAC
TACTCAGATGAGGAGATTTGGAAGGCCTTGGAGCTGGCTCACCTCAAGTCTTTTGTGGCC
AGCCTGCAACTTGGGTTATCCCACGAAGTGACAGAGGCTGGTGGCAACCTGAGCATAGGC
CAGAGGCAGCTGCTGTGCCTGGGCAGGGCTCTGCTTCGGAAATCCAAGATCCTGGTCCTG
GATGAGGCCACTGCTGCGGTGGATCTAGAGACAGACAACCTCATTCAGACGACCATCCAA
AACGAGTTCGCCCACTGCACAGTGATCACCATCGCCCACAGGCTGCACACCATCATGGAC
AGTGACAAGGTAATGGTCCTAGACAACGGGAAGATTATAGAGTGCGGCAGCCCTGAAGAA
CTGCTACAAATCCCTGGACCCTTTTACTTTATGGCTAAGGAAGCTGGCATTGAGAATGTG
AACAGCACAAAATTCTAG

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
U63970

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_13_Locus:
10q24

# Macromolecular_Interacting_Partner_13_SNPs:
rs2273697; rs927344; rs7080681; rs8187699; rs8187692; rs17216317; rs17222723; rs8187710; rs17222674; rs17222547; rs8187706; rs3740070; rs8187709; rs8187707; rs3740066; rs17216198; rs7899457; rs17216296; rs1137968; rs4267009; rs34937870; rs717620; rs17216156; rs2002042; rs2804400; rs2756109; rs2073337; rs2756114; rs8187674; rs3740065; rs2756104; rs4148396; rs4148397; rs7393105; rs3740063; rs6584327; rs3740073; rs4148398; rs2756106; rs2756112; rs7476245; rs3740064; rs3740074; rs17112266; rs4581377; rs2756103; rs9794323; rs11818057; rs3758395; rs7914602; rs4148399; rs2073336; rs2756113; rs4148391; rs11597282; rs10786571; rs4148384; rs4077146; rs4148394; rs2756105; rs2804398; rs2224506; rs3740067; rs11595888; rs35885490; rs2756108; rs7901377; rs10883416; rs4919395; rs3780882; rs7920591; rs9794324; rs2902299; rs34839727; rs10082440; rs3780880; rs4611137; rs3740069; rs35408364; rs7393085; rs7900740; rs12257125; rs10748792; rs7090621; rs34456559; rs7922379; rs9633711; rs4148395; rs34660705; rs11190291; rs11816875; rs10883417; rs2756111; rs2804399; rs34683029; rs7898096; rs7906080; rs35509621; rs3740068; rs9943464; rs12257158; rs10883413; rs11498758; rs10786572; rs2804397; rs7922376; rs10748791; rs1962102; rs9804274; rs4362077; rs2756110; rs10883414; rs9794322; rs9633710; rs7076773; rs7920448; rs1885301; rs7910642; rs2804402; rs12251995; rs3740071; rs3740072; rs41318029; rs4148400; rs41286890; rs4148401; rs11362742; rs35648207; rs12268545; rs35371064; rs11498759; rs12771624; rs28697226; rs11190289; rs10450371; rs35688626; rs2862689; rs35000277; rs35762771; rs33925378; rs35125216; rs4994144; rs3824610; rs10667377; rs12252945; rs35530113; rs34849284; rs35428269; rs34871071; rs4148392; rs34542394; rs10579032; rs34992254; rs3893194; rs9731882; rs10561194; rs35963473; rs33998610; rs34709093; rs2281637; rs35827068; rs11190286; rs9733831; rs3047481; rs34662003; rs35138969; rs34959207; rs9733799; rs9420768; rs4148393; rs10577917; rs9731254; rs35683214; rs11817399; rs4412694; rs34351781; rs36233263; rs41318033; rs1136912; rs12253584; rs35296652; rs10883415; rs34967745; rs7900969; rs11598792; rs7078268; rs41286888; rs3893193; rs11498760; rs35883614; rs4439452; rs41318031; rs28434545; rs4427497; rs35152927; rs7922864; rs33947178; rs10644836; rs28498571; rs10453988; rs34093243; rs33948136; rs34256643; rs11190288; rs9731258; rs3047477; rs11190290; rs11190294; rs11594329; rs36042666; rs35852420; rs3961715; rs4148383; rs34382900; rs35836893; rs3780881; rs28409805; rs35388339; rs10683821; rs7394179; rs34343354; rs34401027; rs9731264; rs35091989; rs12240781; rs3047479; rs10082536; rs5787360; rs35682621; rs5787361; rs4148402; rs34743267; rs12258415; rs34937591; rs28537453; rs34918146; rs5013873; rs28532665; rs11190287; rs12359960; rs7901067; rs10555122; rs11442349; rs35567746; rs41318025; rs36012424; rs35853830; rs10559742; rs4919397; rs34706355; rs7899330; rs12253129; rs41318027; rs34398741; rs35444155; rs41318023; rs11592017; rs2490765; rs34423076; rs34009725; rs34827047; rs34834811; rs35066717; rs3047475; rs34693955; rs34200720; rs35059917; rs11190295; rs11190297; rs11190298; rs1137675; rs11816708; rs12268782; rs12762549; rs12826; rs17216149; rs17216177; rs17216212; rs17216345; rs17222540; rs17222554; rs17222561; rs17222589; rs17222596; rs17222610; rs17222624; rs17222632; rs17222744; rs17580483; rs2145852; rs2145853; rs2180989; rs2180990; rs2249983; rs2756098; rs2756107; rs4148385; rs4148386; rs4148387; rs4148388; rs4148389; rs7067971; rs7068581; rs7476419; rs7898268; rs7899883; rs7903716

# Macromolecular_Interacting_Partner_13_General_References:
8797578; 8662992; 10464142; 11076395; 11500505; 9425227; 10053008; 11093739; 11477083; 11266082

# Macromolecular_Interacting_Partner_13_References:
12763363

# Macromolecular_Interacting_Partner_14_ID:
5692

# Macromolecular_Interacting_Partner_14_Name:
Solute carrier organic anion transporter family member 1B1

# Macromolecular_Interacting_Partner_14_Synonyms:
Solute carrier family 21 member 6; Sodium-independent organic anion- transporting polypeptide 2; OATP 2; Liver-specific organic anion transporter 1; LST-1; OATP-C

# Macromolecular_Interacting_Partner_14_Gene_Name:
SLCO1B1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Solute carrier organic anion transporter family member 1B1
MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
NGSVMDEANLESLNKNKHFVPSAGADSETHC

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
691

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
76450

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_14_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_14_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
97-117
207-227
259-279
336-356
376-396
410-430
575-595

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
5051630

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
SO1B1_HUMAN (Q9Y6L6)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
SLCO1B1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
SLCO1B1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:10959

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Cell membrane; basolateral cell membrane; multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>2076 bp
ATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAACCTTCAGAGAATAAGAAA
ACAAGATACTGCAATGGATTGAAGATGTTCTTGGCAGCTCTGTCACTCAGCTTTATTGCT
AAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAG
ATATCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTGGAAATTTGCTTGTG
ATTGTATTTGTGAGTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGT
TGTTTCATTATGGGAATTGGAGGTGTTTTGACTGCTTTGCCACATTTCTTCATGGGATAT
TACAGGTATTCTAAAGAAACTAATATCAATTCATCAGAAAATTCAACATCGACCTTATCC
ACTTGTTTAATTAATCAAATTTTATCACTCAATAAAGCATCACCTGAGATAGTGGGAAAA
GGTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAATATGCTT
CGTGGAATAGGGGAGACTCCCATAGTACCACTGGGGCTTTCTTACATTGATGATTTCGCT
AAAGAAGGACATTCTTCTTTGTATTTAGGTATATTGAATGCAATAGCAATGATTGGTCCA
ATCATTGGCTTTACCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTT
AATCTAAGCACTATCAGGATAACTCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTT
AATTTCCTTGTGTCTGGACTATTCTCCATTATTTCTTCCATACCATTCTTTTTCTTGCCC
CAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGTCTTTGCATGTGCTGGAA
ACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATATTACCAAA
AATGTGACTGGTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATG
TTTGTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTC
AAATACGTAGAGCAACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGGGAGTC
ATAACCATACCTATTTTTGCAAGTGGAATGTTTTTAGGAGGATATATCATTAAAAAATTC
AAACTGAACACCGTTGGAATTGCCAAATTCTCATGTTTTACTGCTGTGATGTCATTGTCC
TTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAGTTGCCGGACTAACCATG
ACCTATGATGGAAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTATTGCAAC
TCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACT
TACATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATAGTG
TTTTACAACTGCAGTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCAT
TTGGGTGAATGCCCAAGAGATGATGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATA
CAAGTCTTGAATTTATTTTTCTCTGCACTTGGAGGCACCTCACATGTCATGCTGATTGTT
AAAATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCCACTCAATGGTTATACGA
GCACTAGGAGGAATTCTAGCTCCTATATATTTTGGGGCTCTGATTGATACAACGTGTATA
AAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCA
TTTTCAAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATAT
ATTATATTAATTTATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAA
AATGGAAGTGTCATGGATGAAGCAAACTTAGAATCCTTAAATAAAAATAAACATTTTGTC
CCTTCTGCTGGGGCAGATAGTGAAACACATTGTTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF060500

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_14_Locus:
12p

# Macromolecular_Interacting_Partner_14_SNPs:
rs2306283; rs4149056; rs2306282; rs11045819; rs11045852; rs34671512; rs2291075; rs4149057; rs11045818; rs11045854; rs11045859; rs3829310; rs3829307; rs3829306; rs1292914; rs2010668; rs4149085; rs7296230; rs11045891; rs12370655; rs11045782; rs4149087; rs7484637; rs12816706; rs1101248; rs4149088; rs11045783; rs4149019; rs1101250; rs4149018; rs10841752; rs3829309; rs11045784; rs2417954; rs2169970; rs999278; rs2417955; rs2061903; rs1000691; rs2291076; rs1564364; rs12812279; rs2900478; rs7973095; rs7137959; rs12320965; rs717958; rs6487213; rs4149026; rs3899743; rs717959; rs4149033; rs1564365; rs11045799; rs10743408; rs2199763; rs976754; rs4149061; rs2291077; rs4149042; rs4149069; rs2417957; rs4149022; rs4762698; rs11045823; rs4149062; rs2291073; rs11045786; rs987839; rs4149063; rs7295464; rs7299630; rs7139376; rs7969061; rs11045878; rs11045808; rs4149035; rs7969341; rs7966613; rs2417968; rs4149044; rs7137060; rs11045796; rs2219828; rs11045815; rs10841753; rs7965941; rs1120964; rs12372124; rs11045821; rs16923519; rs10841754; rs1871395; rs12427008; rs4149034; rs11045864; rs7966129; rs17329885; rs981264; rs4149045; rs11045785; rs4149050; rs4363657; rs11830252; rs4149064; rs2100996; rs7966037; rs4149058; rs7966269; rs981262; rs10841767; rs11045816; rs7296796; rs11045829; rs11045813; rs4149041; rs7978219; rs4149051; rs4149053; rs12305884; rs7962588; rs4149029; rs4149078; rs11045848; rs2417966; rs964614; rs7138177; rs11045825; rs7313506; rs11045863; rs7489119; rs4149032; rs7977197; rs10841763; rs10444413; rs4149040; rs7136150; rs4149036; rs4149054; rs1564370; rs7136445; rs12578392; rs12582717; rs964615; rs12310216; rs2417967; rs4149081; rs7966581; rs4149073; rs2169968; rs11045797; rs7966448; rs4149048; rs4149037; rs11045824; rs1987385; rs7486079; rs7969160; rs11045820; rs11045834; rs7310315; rs11045889; rs12319308; rs4149030; rs991263; rs11045890; rs11045836; rs11045844; rs11045877; rs10841766; rs4149067; rs4762697; rs11045869; rs12829704; rs2086271; rs4149023; rs12297423; rs11045812; rs11045802; rs11045885; rs11045805; rs12366582; rs7977097; rs7358672; rs4149076; rs2417963; rs12580258; rs4149066; rs4312110; rs7959887; rs991262; rs10841762; rs7962226; rs11045870; rs7971917; rs2046032; rs9669752; rs12830367; rs12296695; rs11833223; rs7962004; rs7957064; rs12302130; rs12315464; rs10841755; rs4149072; rs2417956; rs11045868; rs12307624; rs4149025; rs11045876; rs4381410; rs12317268; rs11045881; rs12821068; rs12812795; rs11045790; rs2291074; rs4149068; rs12303713; rs12313639; rs7956893; rs10743410; rs9668441; rs1987386; rs7961665; rs2417961; rs11045879; rs7306982; rs4149084; rs11045800; rs12318652; rs4149046; rs7307371; rs12307943; rs7956506; rs11045789; rs12369881; rs12305163; rs17388851; rs11045822; rs7957274; rs11045857; rs4149075; rs11045814; rs11615107; rs10841756; rs10841758; rs9669758; rs11045884; rs12312746; rs4149074; rs11045862; rs3919879; rs7954542; rs4149028; rs11045809; rs4149071; rs3830216; rs1564369; rs10841764; rs4149047; rs4149049; rs12311454; rs1871396; rs12372300; rs12305852; rs7962129; rs7958771; rs4149021; rs4149038; rs4149052; rs1988807; rs2127301; rs12368356; rs4149070; rs7137806; rs7968318; rs12310977; rs11045887; rs10841760; rs11045803; rs11045845; rs2127303; rs7956885; rs12315627; rs7953338; rs11045831; rs4149031; rs10770791; rs10770789; rs12371604; rs7980544; rs7957297; rs12302293; rs11834710; rs7294549; rs11045858; rs2169969; rs7297468; rs9669760; rs996124; rs12319213; rs12368894; rs12821228; rs10841757; rs10841759; rs11045801; rs1463565; rs10841765; rs1002552; rs11045828; rs7958671; rs4149027; rs4149024; rs12426084; rs11045787; rs12301796; rs7968317; rs12424765; rs10841768; rs7485550; rs11513225; rs2199765; rs10770792; rs2199766; rs6487214; rs7973837; rs7956886; rs10841761; rs4149082; rs1564366; rs10770790; rs11513411; rs11835045; rs12372157; rs4149014; rs17328763; rs11045893; rs11045892; rs4149013; rs11557087; rs4603354; rs11045853; rs3829308; rs4149086; rs34805753; rs35029154; rs4149017; rs34568199; rs34951575; rs12810986; rs4149089; rs35685797; rs4149091; rs34209816; rs34564768; rs1101249; rs12810599; rs4149092; rs4149016; rs1101251; rs1564362; rs34412011; rs9739284; rs12812227; rs12371160; rs35694378; rs28373147; rs11045781; rs35580583; rs12811096; rs12318078; rs1564361; rs1564363; rs4542460; rs11045780; rs36147810; rs4149090; rs12582669; rs34770540; rs2169967; rs35201007; rs35733645; rs11045882; rs11385923; rs11045791; rs5796893; rs11045849; rs35416146; rs7954207; rs10718437; rs11045855; rs35374921; rs12830545; rs12423134; rs35163063; rs34196286; rs34071906; rs35247215; rs12318075; rs7296435; rs28673691; rs10632490; rs4573740; rs34314656; rs33935989; rs28853611; rs35380692; rs7306239; rs35412568; rs1564367; rs35334634; rs11519273; rs34706516; rs10610238; rs12371570; rs11535997; rs7969577; rs4149083; rs35236625; rs35285913; rs2199764; rs11045874; rs11045830; rs11045851; rs12423121; rs35904483; rs4149098; rs34700678; rs11513413; rs11045860; rs3060544; rs12308079; rs34656931; rs3060614; rs12297133; rs35642680; rs11454454; rs34138322; rs11045826; rs12821033; rs35034604; rs35375240; rs12369359; rs11045841; rs5796892; rs34888642; rs4149060; rs11045856; rs7962611; rs11045888; rs35548137; rs35051063; rs4149079; rs2900479; rs34632551; rs12819994; rs35933705; rs35573378; rs3886198; rs12314902; rs12304130; rs11045832; rs34111581; rs12305699; rs7301251; rs35406304; rs12579183; rs12303414; rs35462387; rs11519274; rs34413949; rs9669765; rs34276829; rs11407708; rs2417964; rs34527818; rs35157563; rs1564368; rs12303159; rs11045840; rs11533476; rs11045806; rs11282766; rs11045873; rs7966270; rs11522782; rs7978260; rs12146883; rs34679454; rs12306105; rs4322445; rs34728625; rs34943592; rs12371691; rs35736025; rs6487212; rs4620775; rs35722973; rs5796891; rs34804201; rs28588986; rs35928112; rs12367262; rs12316905; rs17330253; rs12367888; rs7955751; rs11045842; rs4149099; rs11045807; rs34447226; rs7971855; rs35639129; rs12319834; rs4149065; rs2900477; rs34483590; rs7971104; rs11513414; rs28782899; rs12423136; rs11045827; rs12580064; rs34867520; rs3962562; rs12423123; rs4149077; rs12366994; rs11045872; rs12826050; rs7953829; rs3060502; rs34366034; rs10697756; rs7978634; rs12313667; rs11045838; rs11045875; rs34882548; rs35706009; rs11045798; rs12306098; rs2417965; rs35399651; rs7315147; rs12367371; rs35901911; rs4149096; rs12313491; rs11045883; rs4149100; rs12317451; rs6487211; rs11045886; rs34474710; rs12812334; rs4149080; rs35448052; rs12303784; rs35133125; rs4149043; rs7975393; rs12423150; rs36005374; rs11045833; rs11045788; rs4149055; rs11045866; rs11045793; rs35366829; rs2900476; rs12814646; rs35767860; rs11045861; rs7971088; rs35056525; rs35577038; rs2417962; rs10466794; rs35786525; rs11045847; rs3060579; rs34234515; rs34241429; rs11385920; rs11045850; rs11045837; rs4149059; rs12815795; rs11045871; rs11045839; rs11045792; rs28854565; rs35653374; rs7966140; rs11045811; rs11519275; rs12316911; rs9634094; rs34793374; rs35515882; rs34702734; rs34244521; rs12313499; rs7132052; rs11357260; rs35641021; rs11045846; rs12833325; rs11045843; rs11519272; rs35924420; rs35152201; rs11610616; rs34577475; rs4149015; rs10841751; rs10841769; rs11045776; rs11045777; rs11045778; rs11045895; rs11045900; rs11045901; rs12368786; rs12370842; rs12372067; rs12372111; rs12372162; rs17387842; rs327543; rs327544; rs327545; rs4149012; rs704166; rs7302619; rs7302951; rs7303299; rs7960384; rs7960688; rs7966893; rs852549; rs852550

# Macromolecular_Interacting_Partner_14_General_References:
10358072; 10601278; 10644574; 10779507; 11477075; 12196548; 12130747

# Macromolecular_Interacting_Partner_14_References:
14530907; 16479312

# Macromolecular_Interacting_Partner_15_ID:
7885

# Macromolecular_Interacting_Partner_15_Name:
Gamma-glutamyltranspeptidase 1 precursor

# Macromolecular_Interacting_Partner_15_Synonyms:
Gamma- glutamyltransferase 1; GGT 1; CD224 antigen[Contains: Gamma- glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain]

# Macromolecular_Interacting_Partner_15_Gene_Name:
GGT1

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Gammaglutamyltranspeptidase 1 precursor
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRD
GGSAVDAAIA
ALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMF
NSSEQSQKGGLSVAVPGEIRG
YELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAAL
ENKRTVIEQQPVLCEVFCRDRKVLREGERLTL
PQLADTYETLAIEGAQAFYNGSLTAQI
VKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAP
LSGPVLALILNILKGY
NFSRESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFF
AAQLR
AQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGI
LFNNE
MDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGG
TQITTATALAIIYNLW
FGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHH
TQIASTFIAVVQAIVRTAGGWAAASDS
RKGGEPAGY

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
569

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
61411

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
7.14

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring amino-acyl groups
Function:  gamma-glutamyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_15_Specific_Function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive

# Macromolecular_Interacting_Partner_15_Pathway:
map00430  Taurine and hypotaurine metabolism;
 map00450  Selenoamino acid metabolism;
 map00460  Cyanoamino acid metabolism;
 map00480  Glutathione metabolism;
 map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_15_Reaction:
(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF01019:G_glu_transpept

# Macromolecular_Interacting_Partner_15_Signals:
1-30

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.3.2.2

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
183138

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
GGT1_HUMAN (P19440)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
GGT1

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
GGT1

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:4250

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1710 bp

ATGAAGAAGAAGTTAGTGGTGCTGGGCCTGCTGGCCGTGGTCCTGGTGCTGGTCATTGT
CGGCCTCTGTC
TCTGGCTGCCCTCAGCCTCCAAGGAACCTGACAACCATGTGTACACCA
GGGCTGCCGTGGCCGCGGATGC
CAAGCAGTGCTCGAAGATTGGGAGGGATGCACTGCGG
GACGGTGGCTCTGCGGTGGATGCAGCCATTGCA
GCCCTGTTGTGTGTGGGGCTCATGAA
TGCCCACAGCATGGGCATCGGGGGTGGCCTCTTCCTCACCATCT
ACAACAGCACCACAC
GAAAAGCTGAGGTCATCAACGCCCGCGAGGTGGCCCCCAGGCTGGCCTTTGCCAC
CATG
TTCAACAGCTCGGAGCAGTCCCAGAAGGGGGGGCTGTCGGTGGCGGTGCCTGGGGAGATC
CGAGGC
TATGAGCTGGCACACCAGCGGCATGGGCGGCTGCCCTGGGCTCGCCTCTTCCA
GCCCAGCATCCAGCTGG
CCCGCCAGGGCTTCCCCGTGGGCAAGGGCTTGGCGGCAGCCC
TGGAAAACAAGCGGACCGTCATCGAGCA
GCAGCCTGTCTTGTGTGAGGTGTTCTGCCGG
GATAGAAAGGTGCTTCGGGAGGGGGAGAGACTGACCCTG
CCGCAGCTGGCTGACACCTA
CGAGACGCTGGCCATCGAGGGTGCCCAGGCCTTCTACAACGGCAGCCTCA
CGGCCCAGA
TTGTGAAGGACATCCAGGCGGCCGGGGGCATTGTGACAGCTGAGGACCTGAACAACTACC
G
TGCTGAGCTGATCGAGCACCCGCTGAACATCAGCCTGGGAGACGCGGTGCTGTACATG
CCCAGTGCGCCG
CTCAGCGGGCCCGTGCTGGCCCTCATCCTCAACATCCTCAAAGGGTA
CAACTTCTCCCGGGAGAGCGTGG
AGAGCCCCGAGCAGAAGGGCCTGACGTACCACCGCA
TCGTAGAGGCTTTCCGGTTTGCCTACGCCAAGAG
GACCCTGCTTGGGGACCCCAAGTTT
GTGGATGTGACTGAGGTGGTCCGCAACATGACCTCCGAGTTCTTC
GCTGCCCAGCTCCG
GGCCCAGATCTCTGACGACACCACTCACCCGATCTCCTACTACAAGCCCGAGTTCT
ACA
CGCCGGATGACGGGGGCACTGCTCACCTGTCTGTCGTCGCAGAGGACGGCAGTGCTGTGT
CCGCCAC
CAGCACCATCAACCTCTACTTTGGCTCCAAGGTCCGCTCCCCGGTCAGCGGG
ATCCTGTTCAATAATGAA
ATGGACGACTTCAGCTCTCCCAGCATCACCAACGAGTTTGG
GGTACCCCCCTCACCTGCCAATTTCATCC
AGCCAGGGAAGCAGCCGCTCTCGTCCATGT
GCCCGACGATCATGGTGGGCCAGGACGGCCAGGTCCGGAT
GGTGGTGGGAGCTGCTGGG
GGCACACAGATCACCACGGCCACTGCACTGGCCATCATCTACAACCTCTGG
TTCGGCTA
TGACGTGAAGCGGGCCGTGGAGGAGCCCCGGCTGCACAACCAGCTTCTGCCCAACGTCAC
GA
CAGTGGAGAGAAACATTGACCAGGCAGTGACTGCAGCCCTGGAGACCCGGCACCATC
ACACCCAGATCGC
GTCCACCTTCATCGCTGTGGTGCAAGCCATCGTCCGCACGGCTGGT
GGCTGGGCAGCTGCCTCGGACTCC
AGGAAAGGCGGGGAGCCTGCCGGCTACTGA

# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
J04131

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_15_Locus:
22q11.23

# Macromolecular_Interacting_Partner_15_SNPs:
rs2330837; rs3895576; rs2330838; rs2017869; rs2330795; rs2073398; rs9624507; rs2006092; rs6519520; rs5751901; rs6519519; rs7284489; rs3788375; rs7292010; rs5760495; rs4049889; rs2006094; rs5760494; rs2001180; rs6004192; rs5751905; rs5760493; rs2006227; rs9624506; rs2005589; rs4822516; rs5751904; rs2073397; rs5760492; rs2076999; rs3859862; rs2010657; rs2003757; rs16990490; rs8138050; rs4049918; rs9608300; rs2017188; rs1807629; rs2330797; rs4822517; rs6004195; rs7286626; rs3747117; rs5760491; rs2330805; rs9624510; rs743371; rs3876104; rs4820600; rs5751902; rs5760490; rs6004193; rs6004194; rs8135987; rs8139070; rs5751909; rs5751910; rs9306396; rs9612676; rs5760505; rs2330848; rs5760499; rs5760497; rs5760504; rs4049843; rs9680722; rs2330841; rs524033; rs11913233; rs9680724; rs4049855; rs380131; rs3934421; rs4822523; rs5760500; rs6004203; rs3901297; rs5760498; rs391837; rs5751908; rs9680612; rs3895577; rs4822520; rs4049869; rs3895575; rs7511507; rs7511598; rs389004; rs2236626; rs7285339; rs2330842; rs4049882; rs4049829; rs28621555; rs2330836; rs3966247; rs12159765; rs4049897; rs4049881; rs9612682; rs2330843; rs4049844; rs4049883; rs2330844; rs5751900; rs2330830; rs12169166; rs4049900; rs2330818; rs2330826; rs9624503; rs3966256; rs9612663; rs3966255; rs3895580; rs4049911; rs2877222; rs2330801; rs3033885; rs9624509; rs6004196; rs4049914; rs2330835; rs1832359; rs28509371; rs4049896; rs2298391; rs2330825; rs9624505; rs2877224; rs4049885; rs2330811; rs4049917; rs2330806; rs3876101; rs3887791; rs12484586; rs4049890; rs8139074; rs3895578; rs28550867; rs4049905; rs4049925; rs3966259; rs673673; rs753462; rs4049899; rs2330813; rs8138031; rs4049895; rs28605797; rs3966263; rs3876105; rs9612666; rs2330808; rs2330832; rs2076800; rs13057657; rs3033738; rs3966257; rs2330803; rs2330815; rs4049912; rs3033744; rs2330810; rs2330800; rs3895574; rs6004191; rs8137090; rs2330807; rs2330834; rs4049913; rs28449741; rs2330827; rs3966260; rs9624504; rs2330817; rs9612671; rs4049903; rs2877221; rs5751903; rs2330824; rs2079567; rs2330796; rs4049898; rs11913684; rs2877225; rs2330831; rs4049891; rs4049915; rs2330812; rs4049910; rs4049916; rs4049908; rs12106564; rs3876100; rs3859863; rs3032936; rs9624508; rs4049901; rs12163146; rs4049924; rs4049906; rs2330819; rs9612664; rs3788376; rs3895579; rs2330822; rs2330804; rs2330823; rs2077120; rs2089350; rs2330814; rs2006093; rs4049904; rs9608301; rs3865759; rs2330799; rs3966258; rs28566494; rs2330820; rs3876103; rs2330802; rs4049926; rs3894886; rs3966262; rs2079568; rs2330816; rs2330809; rs2330798; rs2877223; rs4049902; rs8139073; rs4049865; rs4049850; rs4049857; rs2877228; rs28663139; rs4049837; rs4049873; rs4049867; rs4049860; rs28545702; rs34659550; rs3865654; rs4049863; rs28377326; rs3865651; rs4535160; rs4049839; rs11913428; rs2096530; rs28366457; rs4049828; rs3865649; rs9608303; rs4049861; rs6004202; rs2330853; rs6004200; rs4049833; rs10602389; rs9624512; rs4049875; rs2330849; rs3865659; rs3966245; rs2330852; rs12167273; rs4049847; rs2096529; rs4049868; rs7287997; rs4049880; rs4049835; rs3865653; rs11703306; rs4049878; rs2330846; rs3865657; rs35411004; rs2330850; rs5760509; rs12168759; rs9620404; rs4049870; rs9612673; rs5760510; rs4049836; rs28441370; rs12170528; rs4049849; rs4049827; rs4049851; rs3865655; rs4049872; rs3865650; rs6004205; rs5751911; rs4049858; rs4049879; rs2877229; rs2330845; rs6004201; rs12159496; rs4426615; rs4049838; rs2877230; rs12168762; rs28418841; rs4049877; rs3876106; rs28477676; rs5760503; rs3938847; rs9620400; rs2330847; rs4049842; rs28402861; rs28718168; rs3865658; rs4049856; rs2877227; rs12166510; rs4049832; rs7284160; rs2105500; rs11416248; rs493075; rs2877231; rs3966265; rs2330851; rs3966264; rs6004198; rs3897519; rs4049864; rs4049854; rs4049830; rs3865656; rs2845424; rs9612672; rs5751465; rs4049871; rs11912608; rs9620401; rs2330840; rs4049859; rs28451181; rs4049834; rs4049862; rs9612679; rs3034881; rs4049874; rs3865652; rs35525727; rs3035043; rs12158857; rs2330854; rs35882418; rs5760483; rs11318518; rs11913638; rs12158094; rs16978739; rs2070477; rs2154611; rs4820599; rs5760485; rs5760488; rs7287904; rs737128; rs743369; rs743370; rs762286; rs874852; rs928785; rs9608299; rs9830

# Macromolecular_Interacting_Partner_15_General_References:
2904146; 2907498; 2563599; 2568315; 1968061; 1378736; 7689219; 10591208; 2896486; 10392451; 19463; 2900635; 8095045; 7759490; 7673200; 8827453

# Macromolecular_Interacting_Partner_15_References:
7488238; 7560859; 8099310

# Macromolecular_Interacting_Partner_16_ID:
8015

# Macromolecular_Interacting_Partner_16_Name:
Small inducible cytokine A4 precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
CCL4; Macrophage inflammatory protein 1-beta; MIP-1-beta; MIP-1-beta(1-69; T-cell activation protein 2; ACT-2; PAT 744; H400; SIS-gamma; Lymphocyte activation gene 1 protein; LAG-1; HC21; G-26 T-lymphocyte-secreted protein[Contains: MIP-1-beta(3-69]

# Macromolecular_Interacting_Partner_16_Gene_Name:
CCL4

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Small inducible cytokine A4 precursor
MKLCVTVLSLLMLVAAFCSPALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQ
PAVVFQTKRSKQVCADPSESWVQEYVYDLELN

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
92

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
10212

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
4.88

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  chemokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_16_Signals:
1-23

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
178018

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CCL4_HUMAN (P13236)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CCL4

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CCL4

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:10630

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>279 bp
ATGAAGCTCTGCGTGACTGTCCTGTCTCTCCTCATGCTAGTAGCTGCCTTCTGCTCTCCA
GCGCTCTCAGCACCAATGGGCTCAGACCCTCCCACCGCCTGCTGCTTTTCTTACACCGCG
AGGAAGCTTCCTCGCAACTTTGTGGTAGATTACTATGAGACCAGCAGCCTCTGCTCCCAG
CCAGCTGTGGTATTCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGATCCCAGTGAATCC
TGGGTCCAGGAGTACGTGTATGACCTGGAACTGAACTGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
J04130

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_16_Locus:
17q12

# Macromolecular_Interacting_Partner_16_SNPs:
rs1130750; rs1719152; rs9635771; rs1049807; rs1049750; rs2905541; rs1049811; rs1049828; rs1049824; rs1049833; rs1634517; rs1719144; rs2663832; rs1719145; rs1719147; rs1719148; rs4606761; rs1634516; rs7224167; rs2663833; rs1719149; rs1719140; rs1719153; rs9896211; rs1049746; rs1719141; rs1634514; rs1719142; rs7405858; rs2905540; rs10491121; rs1634518; rs1634513; rs1130760; rs1049805; rs1130755; rs1719146; rs1049804; rs1049834; rs1049838; rs1049839; rs1049813; rs1049821; rs1049840; rs1049837; rs1049819; rs1049823; rs1049815; rs1049826; rs9891632; rs2905542; rs11298041; rs7218357; rs1634515; rs1719150; rs9895812; rs4991992; rs4991991; rs4013799; rs3216921; rs34562211; rs4993527; rs7501539; rs2011522; rs940001; rs1719139; rs2376462; rs9895259; rs4993526; rs35451259; rs11658357; rs12453700; rs1357365; rs1619526; rs1619600; rs1622080; rs1626203; rs1634504; rs1634505; rs1634507; rs1634508; rs1634509; rs1634510; rs1634522; rs1634523; rs1634524; rs1634525; rs1719205; rs1719210; rs17617372; rs2072091; rs7207117; rs916839; rs9892580; rs9912185

# Macromolecular_Interacting_Partner_16_General_References:
2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 2809212; 9521068; 8525373; 12070155; 12401480; 8134838

# Macromolecular_Interacting_Partner_16_References:
12388182

# Macromolecular_Interacting_Partner_17_ID:
8186

# Macromolecular_Interacting_Partner_17_Name:
Solute carrier organic anion transporter family member 1A2

# Macromolecular_Interacting_Partner_17_Synonyms:
Solute carrier family 21 member 3; Sodium-independent organic anion transporter; Organic anion-transporting polypeptide 1; OATP1; OATP- A

# Macromolecular_Interacting_Partner_17_Gene_Name:
SLCO1A2

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Solute carrier organic anion transporter family member 1A2
MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGF
INGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVS
VSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGI
SYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTR
WVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYG
ITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGI
YNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINT
SYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMV
FQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMK
SEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYI
YLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTV
LKDDELKTKL

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
670

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
74146

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
5.75

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_17_General_Function:
Not Available

# Macromolecular_Interacting_Partner_17_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_17_Signals:
1-36

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
885978

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
SO1A2_HUMAN (P46721)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
SLCO1A2

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
SLCO1A2

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:10956

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>2013 bp
ATGGGAGAAACTGAGAAAAGAATTGAAACCCATAGAATAAGATGTCTTTCCAAGTTGAAG
ATGTTTCTGTTGGCAATAACATGTGCATTTGTATCCAAAACACTGTCTGGATCTTATATG
AATTCCATGCTCACACAAATAGAGAGACAATTCAACATCCCAACATCTCTAGTTGGATTC
ATTAATGGAAGCTTTGAGATTGGAAATCTTTTGTTGATTATATTTGTGAGTTATTTTGGA
ACCAAACTGCATAGACCTATAATGATTGGCATTGGATGTGTGGTTATGGGCTTAGGCTGT
TTCTTAAAATCACTACCTCATTTCCTCATGAACCAATATGAATATGAATCTACAGTTTCA
GTTTCAGGCAACTTGTCCTCAAACAGTTTCTTGTGTATGGAAAATGGAACCCAGATTTTA
AGACCAACGCAGGATCCATCAGAGTGTACAAAGGAAGTTAAATCATTAATGTGGGTGTAC
GTCCTAGTAGGCAATATTGTACGTGGAATGGGTGAAACTCCCATCCTGCCTTTGGGTATT
TCCTATATAGAAGATTTTGCCAAATTTGAAAATTCTCCTTTATATATTGGGCTTGTAGAA
ACAGGAGCTATTATTGGTCCTTTGATTGGACTTTTGTTGGCATCATTCTGTGCAAATGTT
TATGTTGACACTGGATTTGTGAACACAGATGATCTGATCATAACTCCCACTGACACTCGT
TGGGTCGGTGCATGGTGGTTTGGCTTTCTGATTTGTGCAGGAGTTAACGTGCTCACTGCC
ATTCCTTTTTTCTTTTTGCCCAACACACTTCCAAAGGAAGGACTAGAGACTAATGCTGAC
ATCATTAAAAATGAAAATGAAGACAAACAAAAAGAAGAGGTCAAGAAGGAAAAATATGGA
ATCACTAAAGATTTTCTACCTTTCATGAAAAGTCTTTCCTGCAATCCAATTTATATGCTT
TTCATACTTGTAAGTGTGATACAGTTCAATGCATTCGTTAACATGATCTCCTTCATGCCT
AAATACCTAGAACAGCAATATGGAATATCATCTTCAGATGCAATCTTTCTAATGGGTATT
TATAACTTACCTCCAATATGTATTGGATATATAATTGGTGGTTTAATTATGAAGAAGTTC
AAGATTACTGTCAAACAAGCTGCCCACATAGGATGTTGGTTATCCTTACTTGAGTATCTT
CTCTATTTTTTATCTTTTCTCATGACTTGTGAAAATTCTTCAGTTGTTGGAATAAATACC
TCTTATGAAGGAATTCCACAAGATTTATATGTGGAAAATGACATCTTTGCTGATTGCAAT
GTGGATTGCAACTGTCCATCTAAAATATGGGATCCTGTGTGTGGAAACAATGGCTTGTCA
TATCTGTCAGCTTGTCTTGCTGGTTGTGAGACATCCATTGGAACGGGAATAAACATGGTG
TTCCAAAATTGCAGCTGTATTCAAACATCAGGAAATTCATCTGCAGTTCTTGGGCTGTGC
GACAAAGGACCTGACTGTTCCTTGATGCTCCAGTACTTCCTAATCTTGTCAGCGATGAGC
AGTTTCATTTATTCTTTGGCTGCCATACCTGGATATATGGTTCTCTTGAGGTGTATGAAA
TCTGAAGAGAAGTCCCTTGGTGTGGGATTACATACATTTTGCACAAGAGTATTTGCTGGC
ATTCCTGCACCTATATATTTTGGCGCTTTAATGGATTCCACATGTTTACACTGGGGAACT
TTGAAATGTGGTGAGTCAGGGGCATGCAGGATATATGATTCCACCACCTTCAGATACATC
TACCTCGGATTGCCGGCAGCACTAAGAGGATCAAGCTTTGTTCCAGCCTTAATCATCTTA
ATTCTTTTGAGGAAGTGTCATCTACCTGGTGAAAATGCCTCTTCAGGAACAGAGCTTATA
GAGACAAAAGTCAAAGGGAAGGAAAATGAGTGCAAAGATATATACCAAAAGTCCACGGTT
TTGAAAGATGATGAATTGAAAACTAAATTGTAA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
U21943

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_17_Locus:
12p12

# Macromolecular_Interacting_Partner_17_SNPs:
rs11568567; rs2199688; rs11568563; rs3764045; rs10841795; rs11568574; rs11568554; rs11568550; rs2045938; rs4148978; rs10459076; rs12317073; rs10770797; rs4140389; rs2306229; rs10770805; rs11830638; rs7967770; rs2041613; rs2417977; rs11045919; rs7970493; rs7964783; rs10841791; rs10770800; rs10841802; rs7957203; rs10770801; rs4762701; rs10841801; rs7967902; rs11836987; rs11045994; rs1993906; rs2045941; rs11834359; rs2061825; rs11834836; rs17333047; rs11833771; rs3764042; rs11834777; rs10841797; rs11045971; rs11046010; rs7316461; rs4762700; rs2215732; rs4337089; rs11830952; rs12809573; rs11831407; rs11045988; rs10459074; rs12826226; rs4148977; rs12099523; rs12809856; rs17333533; rs2192172; rs4762699; rs11045970; rs10770804; rs12581287; rs10743413; rs2306231; rs11046008; rs12833409; rs11830214; rs11045972; rs12301085; rs3764041; rs4762818; rs11045967; rs11045969; rs11837182; rs7954757; rs12810446; rs10841798; rs10841803; rs4115170; rs10841800; rs17681288; rs11045968; rs4442593; rs4762819; rs11045920; rs7312628; rs2045943; rs12303202; rs7959833; rs2219791; rs4078; rs7298982; rs10841799; rs7980167; rs17418255; rs10841804; rs12369820; rs11046000; rs10770802; rs12322242; rs2127116; rs11836617; rs12298237; rs11046012; rs34103511; rs11045997; rs11045986; rs2045942; rs9919685; rs1871289; rs12818296; rs10082739; rs2192173; rs4762816; rs11838314; rs12307592; rs7301895; rs2045939; rs17681255; rs12308945; rs2041612; rs10841796; rs11045995; rs9919728; rs12312939; rs7312451; rs12319891; rs3764043; rs11833926; rs7303788; rs11046001; rs12824228; rs2857468; rs12099524; rs12820524; rs7488533; rs2045940; rs7954751; rs11045998; rs11614319; rs11046007; rs764906; rs12823714; rs4762817; rs7980742; rs2306230; rs7960160; rs7313671; rs10770803; rs12818993; rs10459075; rs11046013; rs2219793; rs2417973; rs4149002; rs4148989; rs2169883; rs4148998; rs11045959; rs2417974; rs4148987; rs4148991; rs10841782; rs6487215; rs11045922; rs11045923; rs4148986; rs2417971; rs3764044; rs3751270; rs4149005; rs722994; rs7977517; rs7980842; rs7978981; rs7967354; rs10841794; rs2306227; rs11045960; rs4148993; rs7962263; rs7316412; rs3794320; rs10743411; rs4148999; rs6487216; rs7955581; rs7977483; rs2199686; rs2199684; rs11045944; rs7968331; rs7486475; rs6487217; rs7978322; rs4148992; rs7298793; rs16923663; rs11045978; rs7974575; rs7966334; rs7958005; rs11830939; rs16923597; rs7967303; rs10841789; rs7305911; rs10841786; rs3736080; rs7965059; rs16923647; rs11045974; rs10505872; rs4148984; rs11830367; rs11832394; rs2199685; rs7963398; rs12298817; rs11045980; rs2127117; rs11045953; rs4148990; rs11832851; rs4149003; rs11838023; rs10770796; rs11045962; rs11045946; rs7967935; rs11045975; rs4149001; rs4148988; rs16923623; rs4149000; rs12231212; rs11836396; rs11045948; rs4148996; rs11836945; rs11045942; rs3736081; rs2127118; rs11045930; rs4148995; rs11045958; rs11833627; rs12231738; rs7952736; rs2086194; rs11045945; rs12231484; rs4522218; rs11045954; rs7304940; rs11045961; rs11045950; rs7977652; rs7967403; rs2086193; rs10770795; rs11045931; rs10743412; rs4148994; rs11830971; rs11045924; rs4148982; rs11045976; rs11045957; rs7300463; rs12228765; rs4148997; rs10841783; rs4149004; rs7975612; rs12230401; rs10841790; rs7962919; rs11045952; rs2199687; rs11045926; rs10841784; rs7137014; rs4453284; rs12311809; rs11045965; rs7296472; rs7300346; rs11045932; rs2199683; rs12307908; rs12300594; rs7305484; rs12227319; rs10431251; rs2417972; rs12830245; rs11045934; rs11045955; rs11045921; rs2219792; rs4508253; rs4148985; rs12423510; rs2306226; rs11045933; rs11837357; rs10841787; rs4148983; rs11045956; rs11045925; rs16923608; rs2900480; rs4148981; rs11045927; rs11829484; rs11837359; rs7315667; rs7968842; rs4149008; rs12317843; rs11045917; rs11045918; rs4149006; rs12816792; rs4149009; rs12580098; rs7975594; rs3962563; rs41275204; rs11046009; rs12831290; rs34052201; rs7959775; rs12813247; rs12831653; rs12296154; rs12817281; rs11045999; rs35001636; rs34091985; rs12319570; rs12822994; rs41275202; rs35166807; rs10569114; rs12314592; rs35695485; rs33997554; rs12811254; rs11045984; rs35589853; rs36091983; rs12825593; rs12316436; rs12320968; rs3983535; rs4460854; rs11045990; rs28419468; rs34233148; rs11045996; rs34822370; rs35824274; rs11830993; rs11502680; rs34587587; rs11046004; rs12372118; rs11612222; rs12809265; rs11502681; rs35754317; rs12303996; rs28788610; rs4762820; rs12321375; rs12307186; rs34057845; rs7139223; rs12297072; rs11502426; rs11454466; rs35529364; rs12820826; rs7484455; rs35419909; rs35620370; rs35523483; rs35618589; rs11046006; rs1871288; rs4148979; rs34700187; rs12296813; rs35286038; rs35808554; rs11502425; rs35197974; rs12099528; rs12230953; rs5796898; rs11045992; rs12303719; rs11045993; rs35527094; rs12816889; rs4356287; rs7980490; rs36187285; rs34383451; rs34971713; rs3834939; rs36176879; rs35421887; rs12832693; rs3060709; rs4088; rs34365880; rs12369265; rs12303514; rs12824084; rs11045989; rs12816621; rs7306015; rs11397114; rs34486399; rs34754153; rs7138451; rs10691224; rs35145133; rs7978677; rs2857467; rs11046011; rs35884174; rs11045987; rs11046003; rs35940473; rs34241344; rs12830157; rs12161785; rs1979405; rs12316340; rs5796897; rs34758237; rs2306228; rs12099809; rs11045991; rs10641127; rs34744403; rs11611759; rs11831262; rs34363261; rs12809659; rs34362845; rs34249976; rs10679944; rs34639930; rs11494560; rs7980430; rs12309871; rs4148980; rs28848212; rs34223788; rs12809503; rs12423228; rs11831346; rs7977606; rs11513229; rs12303558; rs12809668; rs7134327; rs4149010; rs11834403; rs7134424; rs12833802; rs10633168; rs35901590; rs11410921; rs11045929; rs12809150; rs34696667; rs34601649; rs12829670; rs12303296; rs12830055; rs11045947; rs11832186; rs35277470; rs11561152; rs12368481; rs35809194; rs12822221; rs12810530; rs3830206; rs12366423; rs11045936; rs12369723; rs34663140; rs41275206; rs28803237; rs11045981; rs11045963; rs28391834; rs5796895; rs11045940; rs11831362; rs34738036; rs35997979; rs3833795; rs11533477; rs11559786; rs12367236; rs12298425; rs10636619; rs11045938; rs11045979; rs7307090; rs11045941; rs7488230; rs11535999; rs7974395; rs12366425; rs12369884; rs5796896; rs12810718; rs28851185; rs11045951; rs34022980; rs34699822; rs35461166; rs34909017; rs11045937; rs36089711; rs34211424; rs35385843; rs3838822; rs7486674; rs34720124; rs11834943; rs12829514; rs11831367; rs11045977; rs35099304; rs12367829; rs11045943; rs4149011; rs35621428; rs3060621; rs11502677; rs34875372; rs11045928; rs3060625; rs12824165; rs11502679; rs11535998; rs3060667; rs34082434; rs12423216; rs34242025; rs12306839; rs11045939; rs35736956; rs12296619; rs12809155; rs35202436; rs12820529; rs11536000; rs28802276; rs35667496; rs12314183; rs12312475; rs1000626; rs34009532; rs11045949; rs11313789; rs3060632; rs12824944; rs34756415; rs3060629; rs28504595; rs12230350; rs34439424; rs11045964; rs12820457; rs12322006; rs34124645; rs34765941; rs12300690; rs11045966; rs34889748; rs11537394; rs34636443; rs35244847; rs35429838; rs12821721; rs12809167; rs11045935; rs12809647; rs35059155; rs12307049; rs4149007; rs34400572; rs12320362; rs3830207; rs1056007; rs10841777; rs10841778; rs10841779; rs10841780; rs10841781; rs11045913; rs11045915; rs11045916; rs11046017; rs11519068; rs11568557; rs11568564; rs11568565; rs11568566; rs11568570; rs11568572; rs11568573; rs11568575; rs11568576; rs11568578; rs11568579; rs11836625; rs12300126; rs12305367; rs12306121; rs12306305; rs12308181; rs12308255; rs12313651; rs12315259; rs12319824; rs12581327; rs12811082; rs12824378; rs12826421; rs17680758; rs17680787; rs1800203; rs2041614; rs2199680; rs2219790; rs2417970; rs34417126; rs34996992; rs3794319; rs4267114; rs4762821; rs4762822; rs4762823; rs5482; rs5483; rs5484; rs5486; rs5487; rs5488; rs5489; rs7137767; rs7311964; rs7350579; rs7953750; rs7967339; rs875234

# Macromolecular_Interacting_Partner_17_General_References:
7557095; 10779507; 11238933

# Macromolecular_Interacting_Partner_17_References:
12130705; 16436656; 9328325

# Macromolecular_Interacting_Partner_18_ID:
7956

# Macromolecular_Interacting_Partner_18_Name:
Ileal sodium/bile acid cotransporter

# Macromolecular_Interacting_Partner_18_Synonyms:
Ileal Na(+/bile acid cotransporter; Na(+-dependent ileal bile acid transporter; Ileal sodium-dependent bile acid transporter; ISBT; IBAT; Apical sodium- dependent bile acid transporter; ASBT; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2

# Macromolecular_Interacting_Partner_18_Gene_Name:
SLC10A2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Ileal sodium/bile acid cotransporter
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVALVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
348

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
37698

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
7.13

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  bile acid:sodium symporter activity
 ||
>>>
Process:  anion transport
Process:  organic anion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF01758:SBF

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
29-49
83-103
127-147
158-178
196-216
225-245
285-305

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
595399

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
NTCP2_HUMAN (Q12908)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
SLC10A2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
SLC10A2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:10906

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1047 bp
ATGAATGATCCGAACAGCTGTGTGGACAATGCAACAGTTTGCTCTGGTGCATCCTGTGTG
GTACCTGAGAGCAATTTCAATAACATCCTAAGTGTGGTCCTAAGTACGGTGCTGACCATC
CTGTTGGCCTTGGTGATGTTCTCCATGGGATGCAACGTGGAAATCAAGAAATTTCTAGGG
CACATAAAGCGGCCGTGGGGCATTTGTGTTGGCTTCCTCTGTCAGTTTGGAATCATGCCC
CTCACAGGATTCATCCTGTCGGTGGCCTTTGACATCCTCCCGCTCCAGGCCGTAGTGGTG
CTCATTATAGGATGCTGCCCTGGAGGAACTGCCTCCAATATCTTGGCCTATTGGGTCGAT
GGCGACATGGACCTGAGCGTCAGCATGACCACATGCTCCACACTGCTTGCCCTCGGAATG
ATGCCGCTGTGCCTCCTTATCTATACCAAAATGTGGGTCGACTCTGGGAGCATCGTAATT
CCCTATGATAACATAGGTACATCTCTGGTTGCTCTCGTTGTTCCTGTTTCCATTGGAATG
TTTGTTAATCACAAATGGCCCCAAAAAGCAAAGATCATACTTAAAATTGGGTCCATCGCG
GGCGCCATCCTCATTGTGCTCATAGCTGTGGTTGGAGGAATATTGTACCAAAGCGCCTGG
ATCATTGCTCCCAAACTGTGGATTATAGGAACAATATTTCCTGTGGCGGGTTACTCCCTG
GGGTTTCTTCTGGCTAGAATTGCTGGTCTACCCTGGTACAGGTGCCGAACGGTTGCTTTT
GAAACGGGGATGCAGAACACGCAGCTATGTTCCACCATCGTTCAGCTCTCCTTCACTCCT
GAGGAGCTCAATGTCGTATTCACCTTCCCGCTCATCTACAGCATTTTCCAGCTCGCCTTT
GCCGCAATATTCTTAGGATTTTATGTGGCATACAAGAAATGTCATGGAAAAAACAAGGCA
GAAATTCCAGAGAGCAAAGAAAATGGAACGGAGCCAGAGTCATCGTTTTATAAGGCAAAT
GGAGGATTTCAACCTGACGAAAAGTAG

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
U10417

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_18_Locus:
13q33

# Macromolecular_Interacting_Partner_18_SNPs:
rs188096; rs157381; rs279941; rs2301159; rs7987433; rs2301157; rs279942; rs16961281; rs3803258; rs279913; rs166833; rs169459; rs157266; rs397268; rs190716; rs183965; rs1886925; rs183963; rs182195; rs279916; rs279914; rs279939; rs279940; rs9300782; rs279917; rs9300784; rs1329515; rs7324197; rs9514092; rs279915; rs9300783; rs7330748; rs9554932; rs279936; rs1854519; rs279912; rs8000956; rs279937; rs7992777; rs4772525; rs16961277; rs9518912; rs696914; rs9557997; rs16961271; rs9514089; rs9586056; rs279938; rs3783238; rs17274342; rs9557994; rs9557996; rs9514091; rs1863441; rs2765583; rs16961268; rs9518913; rs157380; rs17274080; rs10508101; rs279919; rs9518915; rs9582652; rs7324008; rs696915; rs1863444; rs2567774; rs1925978; rs279920; rs9554931; rs7323231; rs1863442; rs9518914; rs7330697; rs17275126; rs9554933; rs12322975; rs9582653; rs1329516; rs3783239; rs9586057; rs11839892; rs17334872; rs1863443; rs457831; rs17273914; rs16961276; rs7324650; rs16961178; rs7139937; rs3753007; rs1886926; rs7323835; rs9300785; rs7337216; rs3837573; rs9557998; rs7330346; rs17273935; rs9514093; rs9586052; rs455925; rs157382; rs3759503; rs3759504; rs7990819; rs9582654; rs9582655; rs7335602; rs12018021; rs16961295; rs157268; rs279935; rs16961285; rs41281678; rs41281680; rs28544361; rs1977488; rs2301158; rs3034259; rs3216781; rs35033949; rs41281676; rs41281682; rs1977489; rs9586053; rs5806337; rs9518909; rs1854520; rs35359827; rs9586055; rs34157445; rs36055220; rs34163791; rs3837572; rs34542141; rs35597421; rs3216821; rs10688538; rs7321830; rs9652098; rs35097190; rs149455; rs35521067; rs35661595; rs11311257; rs9518910; rs34390008; rs413834; rs10695927; rs33930404; rs10644872; rs11408919; rs9586054; rs9514086; rs35462298; rs460577; rs2148161; rs279918; rs3831178; rs35629811; rs11336918; rs456794; rs28587191; rs9557995; rs35548160; rs9518911; rs34429788; rs34206110; rs34241706; rs9557992; rs3759501; rs3759502; rs34919736; rs9586058; rs28548218; rs1005976; rs10508099; rs10508100; rs11618082; rs11840747; rs11841179; rs11843134; rs12873753; rs1365194; rs1549836; rs1571513; rs157383; rs16961116; rs16961307; rs16961311; rs1886927; rs2390845; rs2567775; rs279933; rs6491728; rs6491729; rs696913; rs7319981; rs7329636; rs7986408; rs7992775; rs9514085; rs9518916; rs9582650; rs9582651; rs9586059; rs994720

# Macromolecular_Interacting_Partner_18_General_References:
7592981; 9109432; 12364586; 11589382

# Macromolecular_Interacting_Partner_18_References:
11447228; 15209631; 15834929; 16256913

# Macromolecular_Interacting_Partner_19_ID:
8049

# Macromolecular_Interacting_Partner_19_Name:
Sodium/bile acid cotransporter

# Macromolecular_Interacting_Partner_19_Synonyms:
Na(+/bile acid cotransporter; Na(+/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Cell growth-inhibiting gene 29 protein

# Macromolecular_Interacting_Partner_19_Gene_Name:
SLC10A1

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Sodium/bile acid cotransporter
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
349

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
38120

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
8.94

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  bile acid:sodium symporter activity
 ||
>>>
Process:  anion transport
Process:  organic anion transport
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF01758:SBF

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
25-45
60-80
91-111
120-140
156-176
191-211
220-240
283-303

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
410214

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
NTCP_HUMAN (Q14973)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
SLC10A1

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
SLC10A1

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:10905

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1050 bp
ATGGAGGCCCACAACGCGTCTGCCCCATTCAACTTCACCCTGCCACCCAACTTTGGCAAG
CGCCCCACAGACCTGGCACTGAGCGTCATCCTGGTGTTCATGTTGTTCTTCATCATGCTC
TCGCTGGGCTGCACCATGGAGTTCAGCAAGATCAAGGCTCACTTATGGAAGCCTAAAGGG
CTGGCCATCGCCCTGGTGGCACAGTATGGCATCATGCCCCTCACGGCCTTTGTGCTGGGC
AAGGTCTTCCGGCTGAAGAACATTGAGGCACTGGCCATCTTGGTCTGTGGCTGCTCACCT
GGAGGGAACCTGTCCAATGTCTTCAGTCTGGCCATGAAGGGGGACATGAACCTCAGCATT
GTGATGACCACCTGCTCCACCTTCTGTGCCCTTGGCATGATGCCTCTCCTCCTGTACATC
TACTCCAGGGGGATCTATGATGGGGACCTGAAGGACAAGGTGCCCTATAAAGGCATCGTG
ATATCACTGGTCCTGGTTCTCATTCCTTGCACCATAGGGATCGTCCTCAAATCCAAACGG
CCACAATACATGCGCTATGTCATCAAGGGAGGGATGATCATCATTCTCTTGTGCAGTGTG
GCCGTCACAGTTCTCTCTGCCATCAATGTGGGGAAGAGCATCATGTTTGCCATGACACCA
CTCTTGATTGCCACCTCCTCCCTGATGCCTTTTATTGGCTTTCTGCTGGGTTATGTTCTC
TCTGCTCTCTTCTGCCTCAATGGACGGTGCAGACGCACTGTCAGCATGGAGACTGGATGC
CAAAATGTCCAACTCTGTTCCACCATCCTCAATGTGGCCTTTCCACCTGAAGTCATTGGA
CCACTTTTCTTCTTTCCCCTCCTCTACATGATTTTCCAGCTTGGAGAAGGGCTTCTCCTC
ATTGCCATATTTTGGTGCTATGAGAAATTCAAGACTCCCAAGGATAAAACAAAAATGATC
TACACAGCTGCCACAACTGAAGAAACAATTCCAGGAGCTCTGGGAAATGGCACCTACAAA
GGGGAGGACTGCTCCCCTTGCACAGCCTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
L21893

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_19_Locus:
14q24.1

# Macromolecular_Interacting_Partner_19_SNPs:
rs2296651; rs4646285; rs10130174; rs4646286; rs943277; rs9944036; rs11624523; rs11849924; rs11626135; rs2332167; rs11621916; rs17556915; rs11622925; rs3784152; rs11624532; rs9323529; rs10146486; rs12434773; rs10145643; rs10142031; rs4646295; rs17107282; rs10142027; rs10137162; rs17107278; rs10459536; rs4646287; rs3784153; rs8022592; rs10134553; rs8020042; rs10146088; rs8011311; rs4646296; rs7154439; rs4646297; rs2148505; rs11628646; rs11623504; rs11628755; rs11845658; rs36098664; rs943276; rs28437822; rs35445784; rs3837669; rs10145650; rs35397817; rs35334890; rs10559679; rs4646290; rs34996682; rs4646289; rs4646294; rs8020504; rs35327778; rs11390058; rs34656743; rs3784154; rs35733530; rs35730433; rs35355208; rs35402952; rs11626064; rs34462658; rs36115704; rs10130124; rs10552156; rs3837667; rs34966619; rs34708301; rs35161261; rs10567834; rs28633309; rs28445972; rs28595072; rs10697796; rs10601222; rs35904913; rs11628839; rs35679376; rs34508610; rs10560156; rs10130926; rs10146537; rs1057683; rs1058081; rs12431573; rs12431979; rs12882299; rs1802832; rs1952204; rs1958085; rs2148504; rs2332168; rs2877597; rs3104; rs3105; rs34496118; rs3809399; rs6573908; rs7147944; rs7159823; rs8006833; rs8013586; rs8013598; rs8014019; rs8019166; rs8019999

# Macromolecular_Interacting_Partner_19_General_References:
8132774

# Macromolecular_Interacting_Partner_19_References:
10640286; 11352825; 12065290; 12510858

# Macromolecular_Interacting_Partner_20_ID:
7747

# Macromolecular_Interacting_Partner_20_Name:
AN1, ubiquitin-like, homolog

# Macromolecular_Interacting_Partner_20_Synonyms:
Xenopus laevis

# Macromolecular_Interacting_Partner_20_Gene_Name:
ANUBL1

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>AN1, ubiquitinlike, homolog
MDNRKEPPFFNDDNMGPFYYRLHFCDTMELFIETLTGTCFELRVSPFETVISVKAKIRRL
EGIPICRQHLIWNNMELENDYCLNDYNISEGCTLKLVLAMRGGPINTRRDLQIPR

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
115

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
13565

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00240:ubiquitin

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
55665296

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
Q5VVY2_HUMAN (Q5VVY2)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
ANUBL1

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
ANUBL1

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:23504

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>2184 bp
ATGGATAACAGAAAAGAGCCTCCATTCTTCAATGATGATAACATGGGACCATTTTACTAC
AGACTTCATTTCTGTGATACCATGGAGCTCTTCATTGAAACATTAACTGGAACATGTTTT
GAGCTGAGAGTTTCACCTTTTGAAACTGTTATTTCTGTGAAAGCAAAAATTCGAAGATTG
GAAGGTATTCCCATCTGTCGACAACACTTAATTTGGAATAACATGGAACTTGAAAATGAT
TATTGCTTGAATGATTACAACATTTCAGAAGGGTGTACCTTGAAGCTAGTTTTGGCTATG
CGTGGCGGACCTATAAATACTAGAAGAGTTCCTACAGACGATCCACTTAGGAAGATGGCA
GAGTACTTGGATTCCAGTCGAGTTGAGGTCTGGGAGAAGACCTCCTGCAGCAAACAAGTT
ACATTTTTGGTATACCAAGAAGGAGATCAATTGAATTTCTTTCCTGCAGTAGATAGGGGA
GATGGCACTTTAACACCGTTATCTGACTCTTCAAAGAAAATAGATTTTCATTTGCATGTC
CTACGGAGAAAAGGAGAACATCGTATGAGTGGTGGTTCTATGTATAATTCAGATACAGAT
GAGGATGAAGAAACTGAGCCTTCTTCTTCTGGGCAACAGATAATTGAAAATTCAATAACT
ATGAATAAGATGAAGCTGCTGAAGGCTAAGATGAAGAACATGAATCTCAGCAAAAAGCCT
AAGAAAGCTGTCAAGATAAAACCTCACCCACCTGTAGCTCCTCGACCTTCTAGTGGTTCC
ACTGCACCATCTCGCCACCGATTGTTAAGGGTCCTCCCCAACATTGGTCAATCTTGTTCA
CCTGCTTTTGGGAATGCATATCCGCCCGAAATCTCCAGGAATGGAATTTCAAGTTTGGCA
ACTCAACTCTCTGCTGAGAGATACATATCTTCTATCACTGGTGAATTTCTTAAGGAAGAT
AATAGCTGGGAGAATAACACACTGTCTCACTTCAGTAGCAACGTCAAACTACCTCCTCAG
ATACCCCATTTGGAGTTGGGAAATGACCAGGAGCTTGCTGACTCTGTTCTCCATCTTGGA
TCATCCCTGCCTAGGCAAACAAAACATTTTTTAGGAAACTTGCCATCTAGTAATGGGAAC
ATTGTCTTACCTTCAGAAGAATGTGTAACCGAACAATCACTTCTACCTAAAGTGGGCTCA
CTGGCTTCATTTGCAGAAGGAAATGCTGATGAACAGAGCAGCGGCTTAGAAGGTGCGTGC
AAAGTGAATCTGGAGTTGCTACTCACTAATGCTGACAAAGGGTTGAAAGCTCCAGAGCAG
CATCTCAAGCATGTTGCAGGAGTGCTGAATGGGGAATCAGTAGAGACTTCAGTTCTTAAC
TACCGGGAATTAAGTCCTCACAAGAATAGACTCTTGTCACCTCTTCGCTGTTCTGCACCA
ATGTCGCTACATAATTCTCTGGTGAAACCAGAGAGACAGTCCAAATGTTTTGAGTTTGGG
AAGCTACAGCCTTCTTCTTCTCAGTCACTGGATGTTCAAAACATAACTGATTCTTCTTTC
TCTAGGACTACTTGCTTTCAAGGTGTTAAAGTTGATTCACTTGGGAAAAGATCTGATGTT
ATTTCCAAAGTTGAGGCTCGGGATATCACAGAAATGACTAACAAGGCTTCCAAAGAGCCT
GTTGGTTGTGTAAATAATATCAGTTTTCTTGCCTCACTGGCCGGGAGCACAAGCAGAAAT
AGATTACAGAGCACACGTGGGGCAGGCAGGCTTCAGAACTCTGGAACTGGGCTGTCTACA
AACCTCCAGCATTTTCAGGAAGAAAACTTTAGGAAAAGTTCTCCCCAGTTAGAACATACA
GGAGTTTTTTTGTCTACCCATGGTGTTGGAATGAATGGAAATAATGCAGCAGCAGGGAAA
AGCGTAGGAGAATGTACTACTCATCACCTCCCACCTGTGAAAGCCCCTCTTCAGACAAAG
AAGAAAACAACAAATCATTGTTTTCTTTGTGGAAAGAAAACAGGACTGGCTAGTAGCTAC
GAATGCAGATGTGGAAACAACTTCTGTGCATCTCATCGTTATGCAGAAACTCATGGCTGT
ACCTATGATTACAAGAGTGCAGGGAGGAGATACTTGCACGAGGCAAATCCTGTGGTTAAT
GCACCAAAGCTTCCAAAAATCTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
AL445201

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_20_Locus:
10q11.21

# Macromolecular_Interacting_Partner_20_SNPs:
rs17854567; rs12267385; rs1060848; rs7069223; rs11528544; rs11592630; rs4949013; rs10751387; rs11239577; rs10900232; rs17768650; rs17157945; rs10751386; rs7074524; rs17696005; rs10793621; rs2305299; rs7091141; rs11239585; rs17768692; rs10793622; rs17157941; rs12766066; rs11239586; rs10900229; rs12764555; rs11239580; rs7087287; rs10900230; rs11239587; rs17157944; rs17696011; rs11239582; rs10751385; rs12778159; rs10900231; rs11592669; rs7898761; rs3802543; rs3739965; rs17857362; rs41299230; rs34082391; rs35142284; rs41314982; rs35101253; rs17854568; rs4949014; rs2926329; rs34048645; rs11492889; rs34938900; rs7920461; rs2926327; rs41313826; rs2926328; rs12240731; rs35219365; rs34187732; rs34028441; rs11239583; rs9422661; rs35859169; rs1201436; rs2923044; rs34671659; rs35601286; rs41301629; rs12774796; rs12247223; rs34853665; rs41301631; rs35337666; rs12778934; rs11239576; rs11362238; rs35415235; rs11819162; rs35229531; rs12778943; rs28587306; rs34624161; rs9703030; rs34048465; rs34923160; rs35721167; rs7089133; rs1072929; rs10736836; rs11239584; rs35873337; rs11446488; rs35106684; rs7086332; rs11239579; rs34406643; rs34034843; rs41301627; rs34763590; rs1075000; rs28867788; rs7096342; rs12245469; rs12354709; rs35599803; rs12778926; rs12776675; rs34576059; rs35979489; rs33997594; rs11239578; rs11239581; rs12356629; rs3824617; rs34305372; rs41301625; rs35228493; rs10751384; rs11239574; rs11239575; rs3802542; rs4418752; rs7091808; rs7100819

# Macromolecular_Interacting_Partner_20_General_References:
Not Available

# Macromolecular_Interacting_Partner_20_References:
10209268; 11470901; 17134679; 8223945

# Macromolecular_Interacting_Partner_21_ID:
8025

# Macromolecular_Interacting_Partner_21_Name:
CDNA FLJ16580 fis, clone TESTI2050780

# Macromolecular_Interacting_Partner_21_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_21_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>CDNA FLJ16580 fis, clone TESTI2050780
MFVGVARHSGSQDEVSRGVEPLDAARAQPAKDRRAKGTPKSSKPGKKHRYLRLLPEALIR
FGGFRKRKKAKSSVSKKPGEVDDSLEQPCGLGCLVSTCCECCNNIRCFMIFYCILLICQG
VVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFYGDRKKVIWFVASSFL
IGLGSLLCAFPSINEENKQSKVGIEGIAECTSMIGYALGYVLGAPLVKVPENTTSATKTG
KLGNLTAPCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCTYSKAQNQKKMYYNCSCIKEG
LITADAEGDFIDARPGKCDAKCYKLPLFIAFIFSTLIFSGFSGVPIVLAMTRVVPDKLRS
LALGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHRGRCWIYNKTKMAFLLVGIC
FLCKLCTIIFTTIAFFIYKRRLNENTDFPDVTVKNPKVKKKEETDL

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
466

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
51454

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
9.06

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF07648:Kazal_2;
PF03137:OATP

# Macromolecular_Interacting_Partner_21_Signals:
None

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
108-130; 171-193; 327-349; 415-437

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
47077405

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
Q6ZMY5_HUMAN (Q6ZMY5)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:23613

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1401 bp
ATGTTCGTAGGCGTCGCCCGGCACTCTGGGAGCCAGGATGAAGTCTCAAGGGGAGTAGAG
CCGCTGGATGCCGCGCGGGCCCAGCCTGCTAAGGACAGGAGGGCCAAGGGAACCCCGAAG
TCCTCGAAGCCCGGGAAAAAACACCGGTATCTGAGACTACTTCCAGAGGCCTTGATAAGG
TTCGGCGGTTTCCGAAAAAGGAAAAAAGCCAAGTCCTCAGTTTCCAAGAAGCCGGGAGAA
GTGGATGACAGTTTGGAGCAGCCCTGTGGTTTGGGCTGCTTAGTCAGCACCTGCTGTGAG
TGTTGCAATAACATTCGCTGCTTCATGATTTTCTACTGCATCCTGCTCATATGTCAAGGT
GTGGTGTTTGGTCTTATAGATGTCAGCATTGGCGATTTTCAGAAGGAATATCAACTGAAA
ACCATTGAGAAGTTGGCATTGGAAAAGAGTTACGATATTTCATCTGGCCTGGTAGCAATA
TTTATAGCATTCTATGGAGACAGAAAAAAAGTAATATGGTTTGTAGCTTCCTCTTTTTTA
ATAGGACTTGGATCACTTTTATGTGCTTTTCCATCCATTAATGAAGAAAATAAACAAAGT
AAGGTAGGAATTGAAGGTATTGCAGAATGTACATCAATGATTGGATATGCTCTGGGTTAT
GTGCTAGGAGCACCACTAGTTAAAGTCCCTGAGAATACTACTTCTGCAACAAAAACAGGG
AAGTTGGGAAACCTCACGGCTCCTTGCAATGAAAAATGTAGATGCTCATCTTCAATTTAT
TCTTCTATATGTGGAAGAGATGATATTGAATATTTTTCTCCCTGCTTTGCAGGGTGTACA
TATTCTAAAGCACAAAACCAAAAAAAGATGTACTACAATTGTTCTTGCATTAAAGAAGGA
TTAATAACTGCAGATGCAGAAGGTGATTTTATTGATGCCAGACCCGGGAAATGTGATGCA
AAGTGCTATAAGTTACCTTTGTTCATTGCTTTTATCTTTTCTACACTTATATTTTCTGGT
TTTTCTGGTGTACCAATCGTCTTGGCCATGACGCGGGTTGTACCTGACAAACTGCGTTCT
CTGGCCTTGGGTGTAAGCTATGTGATTTTGAGAATATTTGGGACTATTCCTGGACCATCA
ATCTTTAAAATGTCAGGAGAAACTTCTTGTATTTTACGGGATGTTAATAAATGTGGACAC
AGAGGACGTTGTTGGATATATAACAAGACAAAAATGGCTTTCTTATTGGTAGGAATATGT
TTTCTTTGCAAACTATGCACTATCATCTTCACTACTATTGCATTTTTCATATACAAACGT
CGTCTAAATGAGAACACTGACTTCCCAGATGTAACTGTGAAGAATCCAAAAGTTAAGAAA
AAAGAAGAAACTGACTTGTAA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
AK131445

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_21_Locus:
Not Available

# Macromolecular_Interacting_Partner_21_SNPs:
Not Available

# Macromolecular_Interacting_Partner_21_General_References:
Not Available

# Macromolecular_Interacting_Partner_21_References:
8768705; 9928634

# Macromolecular_Interacting_Partner_22_ID:
7838

# Macromolecular_Interacting_Partner_22_Name:
PACAP protein

# Macromolecular_Interacting_Partner_22_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>PACAP protein
MVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQQGRGALEALLCGGPQGACSEKVSATREE
L

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
61

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
6606

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
4.92

# Macromolecular_Interacting_Partner_22_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
31455257

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
Q7Z6N2_HUMAN (Q7Z6N2)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_22_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>186 bp
ATGGTCACAGGGGGCCCCTGGCCTACCAGGCTCTCCAGGACATGTTTGCACTACTTGGGG
GAGTTTGGAGAAGACCAGATCTATGAAGCCCACCAACAAGGCCGAGGGGCTCTGGAGGCA
TTGCTATGTGGGGGACCCCAGGGGGCCTGCTCAGAGAAGGTGTCAGCCACAAGAGAAGAG
CTCTAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
BC009931

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_22_Locus:
Not Available

# Macromolecular_Interacting_Partner_22_SNPs:
Not Available

# Macromolecular_Interacting_Partner_22_General_References:
12477932

# Macromolecular_Interacting_Partner_22_References:
15646343; 15702783

# Macromolecular_Interacting_Partner_23_ID:
8766

# Macromolecular_Interacting_Partner_23_Name:
Solute carrier organic anion transporter family member 4A1

# Macromolecular_Interacting_Partner_23_Synonyms:
Solute carrier family 21 member 12; Sodium-independent organic anion transporter E; Organic anion-transporting polypeptide E; OATP-E; Colon organic anion transporter; Organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT

# Macromolecular_Interacting_Partner_23_Gene_Name:
SLCO4A1

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Solute carrier organic anion transporter family member 4A1
MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLC
QLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTV
NGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLM
GTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVG
ATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELT
TESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEA
SNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASE
AATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVP
MAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATET
NVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALT
ATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQN
SAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQS
SV

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
722

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
77194

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF07648:Kazal_2
PF03137:OATP

# Macromolecular_Interacting_Partner_23_Signals:
1-188

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
104-124
144-164
172-192
229-249
263-283
309-329
372-392
424-444
454-474
579-599
617-637
667-687

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
6683743

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
SO4A1_HUMAN (Q96BD0)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
SLCO4A1

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
SLCO4A1

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:10953

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2169 bp
ATGCCCCTGCATCAGCTGGGGGACAAGCCGCTCACCTTCCCCAGCCCCAACTCAGCCATG
GAAAACGGGCTTGACCACACCCCACCCAGCAGGAGGGCATCCCCGGGCACACCCCTGAGC
CCCGGCTCCCTCCGCTCCGCTGCCCATAGCCCCCTGGACACCAGCAAGCAGCCCCTCTGC
CAGCTCTGGGCCGAGAAGCATGGCGCCCGGGGGACCCATGAGGTGCGGTACGTCTCGGCC
GGGCAGAGCGTGGCGTGCGGCTGGTGGGCCTTCGCACCGCCGTGCCTGCAGGTCCTCAAC
ACGCCCAAGGGCATCCTGTTCTTCCTGTGTGCGGCCGCATTCCTGCAGGGGATGACTGTG
AATGGCTTCATCAACACAGTCATCACCTCCCTGGAGCGCCGCTATGACCTGCACAGCTAC
CAGAGCGGGCTCATCGCCAGCTCCTACGACATTGCCGCCTGCCTCTGCCTCACCTTCGTC
AGCTACTTCGGGGGCTCAGGGCACAAGCCGCGCTGGCTGGGCTGGGGCGTGCTGCTTATG
GGCACGGGGTCGCTGGTGTTCGCGCTGCCCCACTTCACGGCTGGCCGCTATGAGGTGGAG
TTGGACGCGGGTGTCAGGACGTGCCCTGCCAACCCCGGCGCGGTGTGTGCGGACAGCACC
TCGGGCCTGTCCCGCTACCAGCTGGTCTTCATGCTGGGCCAGTTCCTGCATGGCGTGGGT
GCCACACCCCTCTACACGCTGGGCGTCACCTACCTGGATGAGAACGTCAAGTCCAGCTGC
TCGCCCGTCTACATTGCCATCTTCTACACAGCGGCCATCCTGGGCCCAGCTGCCGGCTAC
CTGATTGGAGGTGCCCTGCTGAATATCTACACGGAAATGGGCCGACGGACGGAGCTGACC
ACCGAGAGCCCACTGTGGGTCGGCGCCTGGTGGGTCGGCTTCCTGGGCTCTGGGGCCGCT
GCTTTCTTCACCGCCGTTCCCATCCTTGGTTACCCTCGGCAGCTGCCAGGCTCCCAGCGC
TACGCGGTCATGAGAGCGGCGGAAATGCACCAGTTGAAGGACAGCAGCCGTGGGGAGGCG
AGCAACCCGGACTTTGGGAAAACCATCAGAGACCTGCCTCTCTCCATCTGGCTCCTGCTG
AAGAACCCCACGTTCATCCTGCTCTGCCTGGCCGGGGCCACCGAGGCCACTCTCATCACC
GGCATGTCCACGTTCAGCCCCAAGTTCTTGGAGTCCCAGTTCAGCCTGAGTGCCTCAGAA
GCTGCCACCTTGTTTGGGTACCTGGTGGTGCCAGCGGGTGGTGGCGGCACCTTCCTGGGC
GGCTTCTTTGTGAACAAGCTCAGGCTCCGGGGCTCCGCGGTCATCAAGTTCTGCCTGTTC
TGCACCGTTGTCAGCCTGCTGGGCATCCTCGTCTTCTCACTGCACTGCCCCAGTGTGCCC
ATGGCGGGCGTCACAGCCAGCTACGGCGGGAGCCTCCTGCCCGAAGGCCACCTGAACCTA
ACGGCTCCCTGCAACGCTGCCTGCAGCTGCCAGCCAGAACACTACAGCCCTGTGTGCGGC
TCGGACGGCCTCATGTACTTCTCACTGTGCCACGCAGGGTGCCCTGCAGCCACGGAGACG
AATGTGGACGGCCAGAAGGTGTACCGAGACTGTAGCTGTATCCCTCAGAATCTTTCCTCT
GGTTTTGGCCATGCCACTGCAGGGAAATGCACTTCAACTTGTCAGAGAAAGCCCCTCCTT
CTGGTTTTCATATTCGTTGTAATTTTCTTTACATTCCTCAGCAGCATTCCTGCACTAACG
GCAACTCTACGATGTGTCCGTGACCCTCAGAGATCCTTTGCCCTGGGAATCCAGTGGATT
GTAGTTAGAATACTAGGGGGCATCCCGGGGCCCATCGCCTTCGGCTGGGTGATCGACAAG
GCCTGTCTGCTGTGGCAGGACCAGTGTGGCCAGCAGGGCTCCTGCTTGGTGTACCAGAAT
TCGGCCATGAGCCGCTACATACTCATCATGGGGCTCCTGTACAAGGTGCTGGGCGTCCTC
TTCTTTGCCATAGCCTGCTTCTTATACAAGCCCCTGTCGGAGTCTTCAGATGGCCTGGAA
ACTTGTCTGCCCAGCCAGTCCTCAGCCCCTGACAGTGCCACAGATAGCCAGCTCCAGAGC
AGCGTCTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
AB031051

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_23_Locus:
20q13.33

# Macromolecular_Interacting_Partner_23_SNPs:
rs34419428; rs1047099; rs6011477; rs34985812; rs3195701; rs3843758; rs6011369; rs6062690; rs3908923; rs7347500; rs2250931; rs6062689; rs2427363; rs4809464; rs1055196; rs2427365; rs6122080; rs6062723; rs2257367; rs2250853; rs6011438; rs3901528; rs11698303; rs2282313; rs2427364; rs17311216; rs2427362; rs12626098; rs6010766; rs2427367; rs2236553; rs872626; rs2282314; rs2258022; rs8125918; rs2427370; rs6062738; rs2275328; rs3787538; rs6011521; rs12481701; rs2275326; rs6011481; rs6062771; rs6011446; rs6011452; rs6010809; rs6090156; rs6011529; rs2427369; rs6062747; rs7263918; rs6011454; rs6011499; rs2427368; rs6011475; rs6011517; rs6122335; rs6011470; rs8124538; rs6010817; rs3787537; rs6090151; rs34190517; rs35183172; rs35517884; rs34474569; rs3761305; rs3848677; rs35070077; rs6062699; rs6062721; rs6090200; rs8116891; rs6122262; rs35989912; rs35552404; rs3842839; rs2427366; rs7270333; rs11274335; rs11696226; rs6122260; rs35415836; rs6010765; rs11475266; rs6090138; rs35768141; rs2427361; rs12233293; rs13433258; rs11699211; rs34200533; rs4264609; rs11476030; rs6512306; rs8184618; rs8119890; rs36035368; rs33947323; rs34171302; rs13041871; rs34570058; rs2275327; rs6062760; rs34247780; rs34464543; rs6011498; rs35150862; rs7270278; rs3838054; rs6011491; rs3060740; rs6011520; rs6010782; rs6011486; rs6090186; rs5842392; rs35059276; rs6090175; rs11421246; rs3827146; rs34701672; rs6090176; rs35667958; rs6011483; rs6062748; rs10624965; rs11475466; rs2277774; rs6062756; rs6011474; rs34471698; rs6090189; rs6011453; rs35977595; rs34442990; rs7263231; rs34340821; rs35747550; rs12626069; rs13037524; rs13037534; rs13040222; rs17318097; rs1815591; rs2185089; rs2313060; rs2313152; rs2427359; rs2427360; rs2427371; rs2427372; rs2427374; rs2427375; rs3915930; rs3915931; rs4239643; rs4549159; rs4606987; rs4809474; rs4809477; rs4809480; rs4809492; rs4809556; rs6010836; rs6010840; rs6011557; rs6011582; rs6011628; rs6011629; rs6011801; rs6062400; rs6062789; rs6062793; rs6062807; rs6062814; rs6062918; rs6089832; rs6089836; rs6089917; rs6090214; rs6122377; rs7261643; rs7266121; rs7267935; rs7271695; rs7273739; rs7274191; rs7508777; rs8123497; rs8124973

# Macromolecular_Interacting_Partner_23_General_References:
10873595; 11316767; 11780052

# Macromolecular_Interacting_Partner_23_References:
Not Available

End of HMDB00036

Beginning of HMDB00037
# Accession_No:
HMDB00037

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:14:23

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Aldosterone

# Description:
Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood.  Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.  It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine.

# Synonyms:
(+)-Aldosterone; (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; (11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al; 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde; 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; 18-Oxocorticosterone; Aldocorten; Aldocortene; Aldocortin; Aldosteronum; Electrocortin; Elektrocortin; Reichstein X; aldosterone; d-Aldosterone; delta-Aldosterone

# Chemical_IUPAC_Name:
11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde

# Chemical_Formula:
C21H28O5

# Chemical_Structure:
tbl_chemical:::HMDB00037_ZOOM.png:::119283147449648866

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00037_THUMB.png:::119283147239863274

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
aldehyde; ketone; primary alcohol; secondary alcohol; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
360.19370

# Molecular_Weight_Avg:
360.44403

# Smiles_String_isomeric:
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4C[C@@H](C[C@]4(C[C@H](O)[C@H]23)C=O)C(=O)CO

# Smiles_String_canonical:
CC12CCC(=O)C=C1CCC3C4CC(CC4(CC(O)C23)C=O)C(=O)CO

# KEGG_Compound_ID:
C01780

# BioCyc_ID:
ALDOSTERONE

# PubChem_CID:
5839

# PubChem_SID:
841789; 4910; 8144488; 625873; 7978658; 3139122; 8153606; 115922; 7885975; 7853718; 148643

# OMIM_ID:
103900; 145260; 201910; 202010; 202355; 203400; 218030; 264350

# Metagene_ID:
CORTICOSTERONE METHYL OXIDASE I DEFICIENCY- CMO I: 486; CORTICOSTERONE METHYL OXIDASE II DEFICIENCY - CMO II: 487; 21-HYDROXYLASE DEFICIENCY (CYP21): 235

# BiGG_ID:
38397

# Wikipedia_ID:
Aldosterone

# METLIN_ID:
418

# Ref_ID:
15814845; 1769794; 8350592; 11686541; 10888242; 14551679; 16146128; 6748658; 11835920; 10440591; 3258645; 16420280; 15630041; 8328738; 15901525; 14694143; 16572107; 2118736; 14621191; 14608520

# ChEBI_ID:
27584

# CAS_Registry_Number:
52-39-1

# InChI:
InChI=1/C21H28O5/c1-20-5-4-14(24)7-13(20)2-3-15-16-6-12(18(26)10-22)8-21(16,11-23)9-17(25)19(15)20/h7,11-12,15-17,19,22,25H,2-6,8-10H2,1H3/t12-,15-,16-,17-,19+,20-,21-/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
166.5 oC

# Melting_Point_predicted:
137.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0512 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.116 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
1.08 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
1.38 [Predicted by ALOGPS]; 0.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::HMDB00037.mol:::1180720963614653365

# SDF_File_[Text]:
tbl_chemical:::HMDB00037.sdf:::119283146543621858

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00037.pdb:::119283147072129608

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Aldosterone.gif:::1132732101265266164

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00037_peaks.txt:::1156309502881880473

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Aldosterone_C.gif:::1132737663886123329

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00037_peaks.txt:::115631069453339352

# Mass_Spectrum:
tbl_chemical:::HMDB00037.jpg:::1132798875609785928

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Adrenal Medulla; Cardiovascular System; Fibroblasts; Intestine; Kidney; Kidneys; Lung; Muscle; Nerves; Pancreas; Placenta; Platelet; Skeletal Muscle; Testes; Testis; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Blood; Saliva; Urine

# Concentration_[Normal]:
Urine	0.01 (0.006-0.014)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests. Fourth Edition 2006 Alan H. B. Hu. Saunders/Elsevier
Blood	0.000026 (0.000008 - 0.000044)	uM	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests. Fourth Edition 2006 Alan H. B. Hu. Saunders/Elsevier
Blood	0.001 (0.000055 -  0.002)	uM	Adult:>18_yrs_old	Both	Normal	15901525
Saliva	<1.00	umol/L	Adult:>18_yrs_old	Both	Normal	6748658


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
21-hydroxylase Deficiency; Adenoma; Aldosteronism; Corticosterone Methyl Oxidase I Deficiency; Corticosterone Methyl Oxidase II Deficiency; Hypokalemia; Primary Aldosteronism

# Pathway_Names:
C21-Steroid hormone metabolism;Bile acid biosynthesis;Androgen and estrogen metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00140;map00120;map00150

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
5808

# Metabolic_Enzyme_1_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_1_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_1_Gene_Name:
CYP11B2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_1_Number_of_Residues:
503

# Metabolic_Enzyme_1_Molecular_Weight:
57561

# Metabolic_Enzyme_1_Theoretical_pI:
9.78

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_1_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_1_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_1_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
CYP11B2

# Metabolic_Enzyme_1_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_1_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_1_Locus:
8q21-q22

# Metabolic_Enzyme_1_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_1_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5822

# Metabolic_Enzyme_2_Name:
3-oxo-5-beta-steroid 4-dehydrogenase

# Metabolic_Enzyme_2_Synonyms:
Delta(4-3- ketosteroid 5-beta-reductase; Aldo-keto reductase family 1 member D1

# Metabolic_Enzyme_2_Gene_Name:
AKR1D1

# Metabolic_Enzyme_2_Protein_Sequence:
>3oxo5betasteroid 4dehydrogenase
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIRE
KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYII
EVPMAFKPGDEIYPRDENGKW
LYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL
ILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQ
QHDIVITAYSPLGTSRNPIWVNVSSPP
LLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERI
KENFQIFDFSLTEEEM
KDIEALNKNVRFVELLMWRDHPEYPFHDEY

# Metabolic_Enzyme_2_Number_of_Residues:
326

# Metabolic_Enzyme_2_Molecular_Weight:
37377

# Metabolic_Enzyme_2_Theoretical_pI:
7.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_2_Reaction:
4,5beta-dihydrocortisone + NADP+ = cortisone + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.3.1.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
431857

# Metabolic_Enzyme_2_SwissProt_ID:
AK1D1_HUMAN (P51857)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
AKR1D1

# Metabolic_Enzyme_2_Geneatlas_id:
AKR1D1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:388

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>981 bp

ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCAT
CATCGGACTTG
GTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACAT
CGGTGAAGGTTGCTATTGACAC
AGGGTACCGACATATTGATGGGGCCTACATCTACCAA
AATGAACACGAAGTTGGGGAGGCCATCAGGGAG
AAGATAGCAGAAGGAAAGGTGCGGAG
GGAAGATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATG
TCCCAGAGATGGTCC
GCCCAACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTA
CATC
ATTGAAGTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGC
AAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAA
AGACGCTGGCTTGGTGA
AATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGC
TCATCCTGAACAAGCCAGGACTCAAACA
CAAGCCAGTCAGCAACCAGGTTGAGTGCCAT
CCGTATTTCACCCAGCCAAAACTCTTGAAATTTTGCCAA
CAACATGACATTGTCATTAC
TGCATATAGCCCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTT
CTTCTCCAC
CTTTGTTAAAGGATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTC
A
AATTGTTTTGCGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAAT
CTTGAAAGGATC
AAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAAT
GAAGGACATTGAAGCCTTGAATA
AAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCG
ATCATCCTGAATACCCATTTCATGATGAATACTG
A

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Z28339

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7q32-q33

# Metabolic_Enzyme_2_SNPs:
rs34703687; rs1872929; rs7780066; rs3735023; rs1872930; rs11763625; rs7799169; rs17169523; rs12540339; rs12532715; rs7780438; rs11763063; rs17169522; rs2306847; rs3805361; rs2120846; rs6467736; rs2035648; rs11982192; rs6467734; rs7799130; rs10263205; rs10280818; rs2166188; rs10269530; rs10257928; rs3805360; rs7784881; rs7795946; rs6956827; rs10226024; rs10278929; rs4728430; rs10236161; rs10954603; rs12111721; rs10228704; rs8180809; rs10276854; rs6943498; rs17169518; rs12668157; rs6980334; rs2035736; rs10263802; rs17169521; rs10954602; rs2306845; rs3805362; rs10264658; rs9642091; rs6945659; rs7799647; rs3857868; rs7784424; rs6943935; rs6951769; rs12670660; rs17169511; rs12670239; rs7799469; rs2306846; rs17169513; rs7783021; rs10279265; rs10229533; rs7784068; rs1872928; rs7803336; rs17543126; rs7784561; rs7784275; rs10244249; rs7780347; rs1038626; rs6467735; rs6977075; rs10264216; rs10279757; rs7797080; rs10228366; rs10280628; rs11762514; rs2352140; rs2035647; rs7794061; rs10280600; rs17169512; rs7784563; rs7788077; rs2882947; rs6962195; rs3816829; rs10230440; rs7784075; rs10258807; rs10085803; rs10229164; rs10236488; rs4732288; rs10244250; rs3807332; rs10246884; rs7779865; rs10231078; rs11766258; rs2465921; rs12540340; rs2465920; rs35535735; rs10274304; rs13243518; rs28601801; rs35429213; rs4732290; rs10230015; rs192475; rs13239794; rs10271851; rs4141795; rs28533201; rs11378949; rs35063839; rs10276951; rs13243967; rs9642092; rs10230284; rs28853972; rs35402657; rs34205888; rs10276855; rs6975550; rs35473428; rs28698638; rs1186272; rs13228410; rs28378643; rs13243508; rs41274197; rs34060691; rs28479257; rs36119043; rs596658; rs13244061; rs13243992; rs13243602; rs10541658; rs10280394; rs7803480; rs10230507; rs35802315; rs2465083; rs13223644; rs9642093; rs41274194; rs35504713; rs34727188; rs28609414; rs34315519; rs3857869; rs34005857; rs5887865; rs35808917; rs13243764; rs1186273; rs10264483; rs10229138; rs7784629; rs34809975; rs10259579; rs35109728; rs34437071; rs28558091; rs34613519; rs35807033; rs35415283; rs13243510; rs7787591; rs3902226; rs28547527; rs34789634; rs28587485; rs10259580; rs11762575; rs11975510; rs4311613; rs11269285; rs35579520; rs35629548; rs34739493; rs35926233; rs10227099; rs10228772; rs10233399; rs10233624; rs10235317; rs10243853; rs10258577; rs1025967; rs10260689; rs10265064; rs10954601; rs11760991; rs11764114; rs11976842; rs1487999; rs1488000; rs1586497; rs1601823; rs17169507; rs17169524; rs17277937; rs1817686; rs1994462; rs2440798; rs2440799; rs2440801; rs2465911; rs2633359; rs2709984; rs2859828; rs34416298; rs3757393; rs4732285; rs6942538; rs6950501; rs6960318; rs7785557; rs7796011; rs7796171; rs7812287; rs9692029

# Metabolic_Enzyme_2_General_References:
7508385; 11342103

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5809

# Metabolic_Enzyme_3_Name:
Cytochrome P450 21

# Metabolic_Enzyme_3_Synonyms:
Cytochrome P450 XXI; Steroid 21- hydroxylase; 21-OHase; P450-C21; P-450c21; P450-C21B

# Metabolic_Enzyme_3_Gene_Name:
CYP21A2

# Metabolic_Enzyme_3_Protein_Sequence:
>Cytochrome P450 21
MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVV
LNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH
KKLTRSALLLGIRDSMEPVVE
QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFG
DKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVD
VIPFLRFFPNPGLRRLKQAIEKRDHIV
EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH
VHMAAVDLLIGGTETT
ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIA
EVLRL
RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN
SRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQ
PFQVRLQPRGMGAHSP
GQNQ

# Metabolic_Enzyme_3_Number_of_Residues:
494

# Metabolic_Enzyme_3_Molecular_Weight:
55888

# Metabolic_Enzyme_3_Theoretical_pI:
7.90

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_3_Specific_Function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_3_Reaction:
a steroid + AH2 + O2 = a 21-hydroxysteroid + A + H2O

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_3_Signals:
1-15

# Metabolic_Enzyme_3_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.99.10

# Metabolic_Enzyme_3_GenBank_ID_Protein:
181290

# Metabolic_Enzyme_3_SwissProt_ID:
CP21A_HUMAN (P08686)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
CYP21A2

# Metabolic_Enzyme_3_Geneatlas_id:
CYP21A2

# Metabolic_Enzyme_3_hgnc_id:
HGNC:2600

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>102 bp

CGCATGAGAGCCCAGCCCGGCACCCCTGTGGCCATTGAGGAGGAATTCTCTCTCCTCAC
CTGCAGCATCA
TCTGTTACCTCACCTTCGGAGACAAGATCAAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M19711

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_3_Locus:
6p21.3

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
3487786; 3486422; 3038528; 1406709; 3871526; 3497399; 1864962; 8081391; 3257825; 2303461; 1937474; 2072928; 1644925; 1406699; 1496017; 8478006; 7749410; 9067760; 9187661; 8989258; 9580109; 9497336; 10094562; 10408778; 10408786; 10051010; 10391209; 12788866; 12915679

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
6443

# Metabolic_Enzyme_4_Name:
Proto-oncogene tyrosine-protein kinase Src

# Metabolic_Enzyme_4_Synonyms:
p60-Src; c- Src; pp60c-src

# Metabolic_Enzyme_4_Gene_Name:
SRC

# Metabolic_Enzyme_4_Protein_Sequence:
>Protooncogene tyrosineprotein kinase Src
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

# Metabolic_Enzyme_4_Number_of_Residues:
536

# Metabolic_Enzyme_4_Molecular_Weight:
59835

# Metabolic_Enzyme_4_Theoretical_pI:
7.47

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.10.2

# Metabolic_Enzyme_4_GenBank_ID_Protein:
10635153

# Metabolic_Enzyme_4_SwissProt_ID:
SRC_HUMAN (P12931)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
SRC

# Metabolic_Enzyme_4_Geneatlas_id:
SRC

# Metabolic_Enzyme_4_hgnc_id:
HGNC:11283

# Metabolic_Enzyme_4_PDB_ID:
2SRC

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Not Available

# Metabolic_Enzyme_4_Gene_Sequence:
>1629 bp
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC
GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG
CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG
CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC
CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG
ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACGAGGAAGGTG
GATGTCAGAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTAC
ATCCCCAGCAACTACGTGGCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGC
AAGATCACCAGACGGGAGTCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACC
TTCCTCGTGCGAGAAAGTGAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTC
GACAACGCCAAGGGCCTCAACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGC
TTCTACATCACCTCCCGCACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCC
AAACACGCCGATGGCCTGTGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAG
ACTCAGGGCCTGGCCAAGGATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTC
AAGCTGGGCCAGGGCTGCTTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGG
GTGGCCATCAAAACCCTGAAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCC
CAGGTCATGAAGAAGCTGAGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAG
GAGCCCATTTACATCGTCACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAG
GGGGAGACAGGCAAGTACCTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCC
TCAGGCATGGCGTACGTGGAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAAC
ATCCTGGTGGGAGAGAACCTGGTGTGCAAAGTGGCGGACTTTGGGCTGGCTCGGCTCATT
GAAGACAATGAGTACACGGCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCA
GAAGCTGCCCTCTATGGCCGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTG
CTGACTGAGCTCACCACAAAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTG
CTGGACCAGGTGGAGCGGGGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTG
CACGACCTCATGTGCCAGTGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTAC
CTGCAGGCCTTCCTGGAGGACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAG
AACCTCTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
AL133293

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_4_Locus:
20q12-q13

# Metabolic_Enzyme_4_SNPs:
rs1885257; rs744285; rs6018000; rs6018156; rs6017996; rs12329503; rs6094509; rs6018027; rs7275012; rs8126089; rs6018088; rs911496; rs6018148; rs6018199; rs6018042; rs1547836; rs6018038; rs747182; rs6018161; rs11905180; rs11697568; rs12106024; rs6090573; rs16986606; rs6017944; rs6094508; rs8117415; rs6063022; rs17785475; rs6018031; rs12480646; rs3762203; rs6012089; rs11905079; rs1547837; rs11908679; rs6063029; rs3940202; rs6090575; rs6094425; rs11907753; rs17787897; rs11906741; rs6012064; rs6066129; rs17194717; rs3762205; rs11697215; rs6090585; rs6018140; rs11904904; rs6018107; rs7269342; rs6017943; rs6018091; rs6011996; rs6018131; rs6018153; rs6017962; rs6018154; rs6017938; rs6018128; rs11908137; rs6090529; rs12479921; rs7347850; rs11908547; rs6090576; rs1573162; rs6018284; rs6018257; rs6018256; rs1570209; rs6124933; rs754625; rs11906658; rs8120573; rs6018246; rs6018233; rs2273677; rs3790149; rs10854173; rs754626; rs6018290; rs6012117; rs12233271; rs6090599; rs3790150; rs6124914; rs6017916; rs6017917; rs6017919; rs7273386; rs6011987; rs35093452; rs6018260; rs34881773; rs13036519; rs6018259; rs6018100; rs11483840; rs6094386; rs6122526; rs34905200; rs6018208; rs10535931; rs6018114; rs6066069; rs6090528; rs11468816; rs6018138; rs36003615; rs6018207; rs6094417; rs6090530; rs35008342; rs11470839; rs6124957; rs11472640; rs6018046; rs6124899; rs35931930; rs34256652; rs6122523; rs35987579; rs35694770; rs11470429; rs34071321; rs35475646; rs11470840; rs6090527; rs6090521; rs35624849; rs35282943; rs6011991; rs11479944; rs6090579; rs6094421; rs12106037; rs6017997; rs12481364; rs6066087; rs41282798; rs34939572; rs6018191; rs11450067; rs6090580; rs34795353; rs6094413; rs6090526; rs6018003; rs6094476; rs7352195; rs11086198; rs35472502; rs35466362; rs35522786; rs6066139; rs6090522; rs6066074; rs4810567; rs6017991; rs33975289; rs6124884; rs3762206; rs6018074; rs8125374; rs36113326; rs35074236; rs3762207; rs11472642; rs6090577; rs7348051; rs6066073; rs11473947; rs6094412; rs6018189; rs6066037; rs35623563; rs3078007; rs6094475; rs35528854; rs34660457; rs6066048; rs6018083; rs5841263; rs7345405; rs35422797; rs13036724; rs8117148; rs6017971; rs34916450; rs6012058; rs11697728; rs7264770; rs6066140; rs36208532; rs6017990; rs6066038; rs35784949; rs35731780; rs6094491; rs6066028; rs41282796; rs6094387; rs11467467; rs35547944; rs35732924; rs35446893; rs13043913; rs4809610; rs6063072; rs28763883; rs13039797; rs35489398; rs6124920; rs3827968; rs4810601; rs4809611; rs13043912; rs33973567; rs6124911; rs2295747; rs11475404; rs6018224; rs8115993; rs6018255; rs13038224; rs11479945; rs6122545; rs35311974; rs6066167; rs6066215; rs33926499; rs6018236; rs10714592; rs33965411; rs6018254; rs6094563; rs11467123; rs6018273; rs6124932; rs11086187; rs6094579; rs35223630; rs11474889; rs6066155; rs28763884; rs2145792; rs4810600; rs35480354; rs28763882; rs4810582; rs35182938; rs34190038; rs6063004; rs35683688; rs6094378; rs11427827; rs35612430; rs10084513; rs10084517; rs11697275; rs11905013; rs11908417; rs11908486; rs16986596; rs16986599; rs4809629; rs4810624; rs6011973; rs6017880; rs6017882; rs6017889; rs6017901; rs6017913; rs6018348; rs6018387; rs6018390; rs6018391; rs6094357; rs6094358; rs6094363; rs6094373; rs6094643; rs6122566; rs6124810; rs7272779; rs8114109; rs8117951; rs8118277; rs8118377

# Metabolic_Enzyme_4_General_References:
11780052; 3299057; 2582238; 2681803; 2581127; 12415108; 9024657; 9174343; 7532003

# Metabolic_Enzyme_4_References:
15699470; 16157790

# Metabolic_Enzyme_5_ID:
5683

# Metabolic_Enzyme_5_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_5_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_5_Gene_Name:
CYP11B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_5_Number_of_Residues:
503

# Metabolic_Enzyme_5_Molecular_Weight:
57530

# Metabolic_Enzyme_5_Theoretical_pI:
9.42

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_5_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_5_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
CYP11B1

# Metabolic_Enzyme_5_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_5_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_5_Locus:
8q21

# Metabolic_Enzyme_5_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_5_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_5_References:
15703266; 16973756; 16984984

# Metabolic_Enzyme_6_ID:
6486

# Metabolic_Enzyme_6_Name:
Mitogen-activated protein kinase 1

# Metabolic_Enzyme_6_Synonyms:
Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1

# Metabolic_Enzyme_6_Gene_Name:
MAPK1

# Metabolic_Enzyme_6_Protein_Sequence:
>Mitogenactivated protein kinase 1
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS


# Metabolic_Enzyme_6_Number_of_Residues:
360

# Metabolic_Enzyme_6_Molecular_Weight:
41390

# Metabolic_Enzyme_6_Theoretical_pI:
6.99

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
Not Available

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_6_GenBank_ID_Protein:
182191

# Metabolic_Enzyme_6_SwissProt_ID:
MK01_HUMAN (P28482)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
MAPK1

# Metabolic_Enzyme_6_Geneatlas_id:
MAPK1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:6871

# Metabolic_Enzyme_6_PDB_ID:
4ERK

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>1083 bp
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGAC
GTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGC
TCTGCTTATGATAATGTCAACAAAGTTCGAGTAGCTATCAAGAAAATCAGCCCCTTTGAG
CACCAGACCTACTGCCAGAGAACCCTGAGGGAGATAAAAATCTTACTGCGCTTCAGACAT
GAGAACATCATTGGAATCAATGACATTATTCGAGCACCAACCATCGAGCAAATGAAAGAT
GTATATATAGTACAGGACCTCATGGAAACAGATCTTTACAAGCTCTTGAAGACACAACAC
CTCAGCAATGACCATATCTGCTATTTTCTCTACCAGATCCTCAGAGGGTTAAAATATATC
CATTCAGCTAACGTTCTGCACCGTGACCTCAAGCCTTCCAACCTGCTGCTCAACACCACC
TGTGATCTCAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCAC
ACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTG
AATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAA
ATGCTTTCCAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAATCACATT
TTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCT
AGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCA
AATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAG
AGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGT
GACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAG
GAAAAGCTAAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCT
TAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M84489

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_6_Locus:
22q11.2|22q11.21

# Metabolic_Enzyme_6_SNPs:
rs1803545; rs3729910; rs6928; rs13943; rs5755074; rs743411; rs3810610; rs17759598; rs2266965; rs2276008; rs2298432; rs1063311; rs9340; rs13515; rs2266966; rs7292198; rs8138018; rs17821423; rs13058; rs2298434; rs2283792; rs2266969; rs743409; rs6518986; rs5749998; rs5755694; rs6518951; rs1892847; rs2266967; rs2283793; rs5999521; rs5755745; rs8141851; rs4821402; rs5999752; rs6518997; rs3788332; rs5750113; rs11912710; rs9607287; rs2276010; rs2283791; rs5999515; rs9607298; rs1892848; rs11912377; rs2283795; rs9610470; rs7292302; rs8141815; rs9610355; rs2283796; rs4821263; rs9610375; rs11704205; rs4821401; rs17213172; rs5999614; rs8136867; rs4821371; rs7284924; rs2266968; rs1892846; rs4821367; rs5755579; rs2070505; rs8139215; rs5755099; rs5999842; rs9610338; rs3827303; rs5749939; rs2154944; rs17759796; rs7290469; rs7286558; rs2876981; rs8135916; rs2283794; rs5751273; rs6518968; rs2006893; rs5999749; rs5999550; rs8136902; rs11704117; rs3729914; rs4821336; rs5755654; rs11703350; rs11913721; rs17820162; rs8142455; rs12159146; rs7285387; rs9610374; rs7510592; rs9680623; rs5749984; rs9607285; rs8136405; rs11704433; rs11704847; rs9607274; rs2096687; rs17213286; rs5999704; rs11703678; rs9610496; rs9610500; rs11913453; rs7290932; rs11704597; rs13053945; rs5999750; rs11089745; rs4821337; rs2329881; rs5749937; rs1557288; rs4640486; rs5999452; rs5749986; rs9610371; rs10222287; rs3729912; rs9610315; rs4821339; rs11705173; rs4516540; rs8135386; rs9610458; rs9680622; rs2027656; rs9610417; rs13055356; rs7292924; rs9610400; rs12172554; rs9610324; rs12628258; rs17821572; rs9610487; rs8140233; rs5999823; rs1557287; rs17004026; rs9607272; rs17003502; rs11913063; rs8136590; rs17821500; rs9607286; rs2276005; rs9607340; rs3810609; rs2276006; rs9610271; rs3810608; rs1048748; rs35401654; rs1130164; rs3188781; rs41282607; rs34573886; rs3810611; rs12158121; rs35774216; rs35450537; rs1048752; rs35268998; rs2276007; rs34155605; rs34338438; rs35097784; rs11704800; rs9607264; rs7292584; rs34478799; rs1803546; rs12168996; rs35926036; rs35419717; rs34746140; rs3891788; rs5999532; rs5999787; rs11913120; rs7289300; rs28727550; rs9610323; rs34349809; rs34637918; rs5999793; rs12167814; rs11704381; rs35051857; rs11703242; rs8141026; rs11462556; rs5755664; rs11273917; rs13053225; rs11414253; rs5755376; rs35061420; rs33953967; rs35881327; rs2186545; rs36122515; rs5995102; rs11393133; rs28780784; rs10598132; rs28862404; rs28373639; rs10222258; rs12373966; rs5999653; rs12159151; rs11390969; rs34007644; rs35825500; rs13058633; rs13055533; rs13056289; rs11267198; rs34347426; rs34196957; rs9610446; rs35225688; rs28370372; rs7285926; rs3949122; rs9624360; rs12484706; rs28704920; rs13058223; rs4821369; rs5999460; rs2298433; rs9712854; rs11303516; rs35736049; rs5749967; rs9610341; rs12628210; rs5999822; rs34042646; rs35604132; rs8142827; rs35276275; rs35913408; rs34915608; rs11705262; rs35967578; rs35791287; rs34033501; rs7286970; rs11426902; rs34817343; rs13054553; rs28513891; rs5755240; rs35418579; rs34412833; rs9610317; rs9610504; rs9610414; rs9607330; rs5995052; rs9712903; rs2008611; rs35950684; rs9610286; rs4478016; rs34544205; rs9610481; rs35001275; rs5999799; rs5999484; rs13056532; rs13056790; rs11405543; rs12169154; rs12163200; rs33914475; rs4050958; rs35723944; rs36031460; rs35843533; rs8136165; rs28720995; rs34842862; rs35399662; rs8141500; rs34987537; rs13057484; rs34644063; rs36123701; rs5999869; rs13054793; rs28763889; rs11385908; rs5755141; rs34431893; rs13055420; rs34550586; rs7284903; rs35676446; rs34145288; rs3052710; rs10663958; rs5755389; rs28803281; rs7284305; rs9680639; rs5755151; rs5999502; rs9623462; rs5999785; rs3052739; rs5999791; rs12159799; rs9610294; rs9610454; rs5844472; rs13058418; rs3729913; rs9610367; rs7289846; rs10599826; rs35444904; rs35220860; rs13056791; rs2329882; rs8140010; rs33986273; rs36087626; rs9610314; rs13056005; rs34522282; rs12158504; rs33922907; rs35578418; rs10641589; rs13057392; rs12172215; rs9622287; rs11360402; rs11490038; rs9607313; rs35389108; rs8142650; rs35096158; rs4050957; rs5755611; rs8136204; rs12172360; rs5999792; rs28566555; rs35248177; rs9607283; rs9622201; rs36031695; rs35318935; rs34416472; rs10714076; rs5999525; rs35644012; rs11277747; rs3729909; rs11703624; rs12170038; rs5755237; rs11089747; rs34534734; rs9610328; rs35907379; rs35585950; rs9607329; rs3841771; rs9680638; rs28697123; rs9607320; rs11352870; rs9610459; rs10598131; rs9610386; rs9610368; rs35593415; rs33932545; rs11272759; rs13058216; rs10664466; rs9622385; rs9622169; rs5999877; rs5999880; rs36042810; rs9610505; rs9607343; rs35549484; rs11914029; rs12157534; rs12160084; rs12167593; rs12627782; rs17759568; rs2876980; rs3810606; rs5749806; rs5749811; rs5754968; rs5754971; rs5755040; rs5999335; rs5999891; rs8139376; rs9607241

# Metabolic_Enzyme_6_General_References:
1540184; 1319925; 12665801; 8794306

# Metabolic_Enzyme_6_References:
15975997; 16087789

# Metabolic_Enzyme_7_ID:
8123

# Metabolic_Enzyme_7_Name:
Renin precursor

# Metabolic_Enzyme_7_Synonyms:
Angiotensinogenase

# Metabolic_Enzyme_7_Gene_Name:
REN

# Metabolic_Enzyme_7_Protein_Sequence:
>Renin precursor
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR

# Metabolic_Enzyme_7_Number_of_Residues:
406

# Metabolic_Enzyme_7_Molecular_Weight:
45058

# Metabolic_Enzyme_7_Theoretical_pI:
7.07

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  pepsin A activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  aspartic-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF07966:A1_Propeptide;
PF00026:Asp

# Metabolic_Enzyme_7_Signals:
1-23

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.4.23.15

# Metabolic_Enzyme_7_GenBank_ID_Protein:
190994

# Metabolic_Enzyme_7_SwissProt_ID:
RENI_HUMAN (P00797)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
REN

# Metabolic_Enzyme_7_Geneatlas_id:
REN

# Metabolic_Enzyme_7_hgnc_id:
HGNC:9958

# Metabolic_Enzyme_7_PDB_ID:
1BBS

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Secreted protein. Membrane. Note=Associated to membranes via binding to ATP6AP2

# Metabolic_Enzyme_7_Gene_Sequence:
>1221 bp
ATGGATGGATGGAGAAGGATGCCTCGCTGGGGACTGCTGCTGCTGCTCTGGGGCTCCTGT
ACCTTTGGTCTCCCGACAGACACCACCACCTTTAAACGGATCTTCCTCAAGAGAATGCCC
TCAATCCGAGAAAGCCTGAAGGAACGAGGTGTGGACATGGCCAGGCTTGGTCCCGAGTGG
AGCCAACCCATGAAGAGGCTGACACTTGGCAACACCACCTCCTCCGTGATCCTCACCAAC
TACATGGACACCCAGTACTATGGCGAGATTGGCATCGGCACCCCACCCCAGACCTTCAAA
GTCGTCTTTGACACTGGTTCGTCCAATGTTTGGGTGCCCTCCTCCAAGTGCAGCCGTCTC
TACACTGCCTGTGTGTATCACAAGCTCTTCGATGCTTCGGATTCCTCCAGCTACAAGCAC
AATGGAACAGAACTCACCCTCCGCTATTCAACAGGGACAGTCAGTGGCTTTCTCAGCCAG
GACATCATCACCGTGGGTGGAATCACGGTGACACAGATGTTTGGAGAGGTCACGGAGATG
CCCGCCTTACCCTTCATGCTGGCCGAGTTTGATGGGGTTGTGGGCATGGGCTTCATTGAA
CAGGCCATTGGCAGGGTCACCCCTATCTTCGACAACATCATCTCCCAAGGGGTGCTAAAA
GAGGACGTCTTCTCTTTCTACTACAACAGAGATTCCGAGAATTCCCAATCGCTGGGAGGA
CAGATTGTGCTGGGAGGCAGCGACCCCCAGCATTACGAAGGGAATTTCCACTATATCAAC
CTCATCAAGACTGGTGTCTGGCAGATTCAAATGAAGGGGGTGTCTGTGGGGTCATCCACC
TTGCTCTGTGAAGACGGCTGCCTGGCATTGGTAGACACCGGTGCATCCTACATCTCAGGT
TCTACCAGCTCCATAGAGAAGCTCATGGAGGCCTTGGGAGCCAAGAAGAGGCTGTTTGAT
TATGTCGTGAAGTGTAACGAGGGCCCTACACTCCCCGACATCTCTTTCCACCTGGGAGGC
AAAGAATACACGCTCACCAGCGCGGACTATGTATTTCAGGAATCCTACAGTAGTAAAAAG
CTGTGCACACTGGCCATCCACGCCATGGATATCCCGCCACCCACTGGACCCACCTGGGCC
CTGGGGGCCACCTTCATCCGAAAGTTCTACACAGAGTTTGATCGGCGTAACAACCGCATT
GGCTTCGCCTTGGCCCGCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
L00073

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1q32

# Metabolic_Enzyme_7_SNPs:
rs11571117; rs11571098; rs11571083; rs5705; rs11571120; rs11571124; rs7521667; rs2887284; rs1464816; rs1917539; rs6693954; rs5706; rs11571123; rs10900555; rs6676670; rs10900557; rs11571079; rs11240688; rs11571108; rs10900556; rs2368564; rs11571104; rs11571102; rs5707; rs11571078; rs11571107; rs11571114; rs11571091; rs11571119; rs11571082; rs11571088; rs11571077; rs11571105; rs11240686; rs11571106; rs3215332; rs3795574; rs11571092; rs11571111; rs3795575; rs11571112; rs2177695; rs3730102; rs11240689; rs11571086; rs6665480; rs11571113; rs3730104; rs11571084; rs3730103; rs11571118; rs11571100; rs11240687; rs11571087; rs2272237; rs6674952; rs11571110; rs11571085; rs11571103; rs11571101; rs11571121; rs11240685; rs11571109; rs11571080; rs11571076; rs11578877; rs11571081; rs11571115; rs11571090; rs6676458; rs11571122; rs11571116; rs6681776; rs6668858; rs6682082; rs11571096; rs11571073; rs11571075; rs11571097; rs11571074; rs11571093; rs11571128; rs11571126; rs11571095; rs11571094; rs11571127; rs11571125; rs6704321; rs11542630; rs34069565; rs1126947; rs1042875; rs5704; rs1042874; rs11799601; rs3730101; rs28580264; rs13306600; rs11284490; rs28730746; rs13306601; rs28417178; rs4439406; rs34296392; rs3839003; rs35241727; rs5708; rs4396166; rs35201130; rs34481638; rs11571099; rs11581713; rs28730747; rs2177694; rs10494849; rs1106778; rs16853059; rs16853062; rs16853072; rs1917542; rs1997034; rs2293337; rs3795576; rs6688425; rs6702587; rs7539596; rs7548714; rs940651; rs940652

# Metabolic_Enzyme_7_General_References:
6324167; 3530608; 6391881; 6138751; 3032746; 2540188; 3516796; 2016271; 12045255; 2493678; 1608447

# Metabolic_Enzyme_7_References:
15351948; 15356010; 15361890; 15364336

# Macromolecular_Interacting_Partner_1_ID:
6554

# Macromolecular_Interacting_Partner_1_Name:
Serine/threonine-protein kinase Sgk1

# Macromolecular_Interacting_Partner_1_Synonyms:
Serum/glucocorticoid-regulated kinase 1

# Macromolecular_Interacting_Partner_1_Gene_Name:
SGK

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serine/threonineprotein kinase Sgk1
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
431

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
48943

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.81

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00069:Pkinase;
PF00433:Pkinase_C

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
1834511

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
SGK1_HUMAN (O00141)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
SGK

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
SGK

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:10810

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1296 bp
ATGACGGTGAAAACTGAGGCTGCTAAGGGCACCCTCACTTACTCCAGGATGAGGGGCATG
GTGGCAATTCTCATCGCTTTCATGAAGCAGAGGAGGATGGGTCTGAACGACTTTATTCAG
AAGATTGCCAATAACTCCTATGCATGCAAACACCCTGAAGTTCAGTCCATCTTGAAGATC
TCCCAACCTCAGGAGCCTGAGCTTATGAATGCCAACCCTTCTCCTCCACCAAGTCCTTCT
CAGCAAATCAACCTTGGCCCGTCGTCCAATCCTCATGCTAAACCATCTGACTTTCACTTC
TTGAAAGTGATCGGAAAGGGCAGTTTTGGAAAGGTTCTTCTAGCAAGACACAAGGCAGAA
GAAGTGTTCTATGCAGTCAAAGTTTTACAGAAGAAAGCAATCCTGAAAAAGAAAGAGGAG
AAGCATATTATGTCGGAGCGGAATGTTCTGTTGAAGAATGTGAAGCACCCTTTCCTGGTG
GGCCTTCACTTCTCTTTCCAGACTGCTGACAAATTGTACTTTGTCCTAGACTACATTAAT
GGTGGAGAGTTGTTCTACCATCTCCAGAGGGAACGCTGCTTCCTGGAACCACGGGCTCGT
TTCTATGCTGCTGAAATAGCCAGTGCCTTGGGCTACCTGCATTCACTGAACATCGTTTAT
AGAGACTTAAAACCAGAGAATATTTTGCTAGATTCACAGGGACACATTGTCCTTACTGAT
TTCGGACTCTGCAAGGAGAACATTGAACACAACAGCACAACATCCACCTTCTGTGGCACG
CCGGAGTATCTCGCACCTGAGGTGCTTCATAAGCAGCCTTATGACAGGACTGTGGACTGG
TGGTGCCTGGGAGCTGTCTTGTATGAGATGCTGTATGGCCTGCCGCCTTTTTATAGCCGA
AACACAGCTGAAATGTACGACAACATTCTGAACAAGCCTCTCCAGCTGAAACCAAATATT
ACAAATTCCGCAAGACACCTCCTGGAGGGCCTCCTGCAGAAGGACAGGACAAAGCGGCTC
GGGGCCAAGGATGACTTCATGGAGATTAAGAGTCATGTCTTCTTCTCCTTAATTAACTGG
GATGATCTCATTAATAAGAAGATTACTCCCCCTTTTAACCCAAATGTGAGTGGGCCCAAC
GAGCTACGGCACTTTGACCCCGAGTTTACCGAAGAGCCTGTCCCCAACTCCATTGGCAAG
TCCCCTGACAGCGTCCTCGTCACAGCCAGCGTCAAGGAAGCTGCCGAGGCTTTCCTAGGC
TTTTCCTATGCGCCTCCCACGGACTCTTTCCTCTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
Y10032

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6q23

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
9114008; 9722955; 14574404; 10548550; 10191262; 10884438; 11154281; 12397388; 12631736

# Macromolecular_Interacting_Partner_1_References:
15452200; 15536167; 15576372; 16099816

# Macromolecular_Interacting_Partner_2_ID:
6752

# Macromolecular_Interacting_Partner_2_Name:
Epidermal growth factor receptor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Receptor tyrosine-protein kinase ErbB-1

# Macromolecular_Interacting_Partner_2_Gene_Name:
EGFR

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Epidermal growth factor receptor precursor
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
1210

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
134279

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.67

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  epidermal growth factor receptor activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  transmembrane receptor protein tyrosine kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  enzyme linked receptor protein signaling pathway
Process:  transmembrane receptor protein tyrosine kinase signaling pathway
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Isoform 2/truncated isoform may act as an antagonist

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00757:Furin-like;
PF07714:Pkinase_Tyr;
PF01030:Recep_L_domain

# Macromolecular_Interacting_Partner_2_Signals:
1-24

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
646-668

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 2.7.10.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
757924

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
EGFR_HUMAN (P00533)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
EGFR

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
EGFR

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:3236

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type I membrane protein. Isoform 2:Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>3633 bp
ATGCGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCG
GCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGAGTAACAAGCTCACGCAG
TTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTG
GTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAG
ACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCT
TTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCA
GTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTA
CAGGAAATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAG
AGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTC
CAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGG
GGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCC
GGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGC
ACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGC
AAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAAC
CCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTG
GTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAA
GACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATA
GGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAA
AACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCC
TTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAA
ATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTT
GAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTC
GTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGAT
GTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTG
TTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAG
GCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCC
AGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAAG
CTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCA
GAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATC
CAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATG
GGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGC
CATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGG
CCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTG
GCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGG
AGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAAC
CAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCC
GGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATT
CCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTC
GATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATC
TGCCTCACCTCCACCGTGCAACTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGAC
TATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAG
ATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCC
AGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAA
CTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGG
ATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTAC
GGGGTGACCGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCC
AGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACC
ATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAG
TTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTC
ATTCAGGGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCC
CTGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACCTCATCCCACAG
CAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCA
ACCAGCAACAATTCCACCGTGGCTTGCATTGATAGAAATGGGCTGCAAAGCTGTCCCATC
AAGGAAGACAGCTTCTTGCAGCGATACAGCTCAGACCCCACAGGCGCCTTGACTGAGGAC
AGCATAGACGACACCTTCCTCCCAGTGCCTGAATACATAAACCAGTCCGTTCCCAAAAGG
CCCGCTGGCTCTGTGCAGAATCCTGTCTATCACAATCAGCCTCTGAACCCCGCGCCCAGC
AGAGACCCACACTACCAGGACCCCCACAGCACTGCAGTGGGCAACCCCGAGTATCTCAAC
ACTGTCCAGCCCACCTGTGTCAACAGCACATTCGACAGCCCTGCCCACTGGGCCCAGAAA
GGCAGCCACCAAATTAGCCTGGACAACCCTGACTACCAGCAGGACTTCTTTCCCAAGGAA
GCCAAGCCAAATGGCATCTTTAAGGGCTCCACAGCTGAAAATGCAGAATACCTAAGGGTC
GCGCCACAAAGCAGTGAATTTATTGGAGCATGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
X00588

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_2_Locus:
7p12

# Macromolecular_Interacting_Partner_2_SNPs:
rs10258568; rs11543848; rs2072454; rs2293347; rs17290103; rs10258429; rs17290169; rs1050171; rs1140475; rs17290005; rs17290559; rs17337023; rs2302536; rs17289686; rs17336437; rs17336800; rs17289893; rs17336988; rs17290162; rs10228436; rs884225; rs10277413; rs712829; rs712830; rs17290225; rs17336995; rs759170; rs980653; rs712831; rs845554; rs759162; rs845561; rs2075112; rs1024748; rs1015793; rs2075110; rs984654; rs2075109; rs845552; rs2877260; rs6593206; rs1404908; rs12532468; rs917880; rs12718945; rs4947491; rs7803660; rs3735064; rs4947979; rs2058502; rs2075107; rs917879; rs887824; rs12668421; rs7798065; rs1344307; rs2330951; rs730437; rs6944695; rs11977660; rs6970029; rs12718946; rs2075101; rs11766798; rs11771471; rs7807517; rs2740763; rs4140770; rs6950826; rs6964647; rs4947963; rs10241326; rs1554718; rs12538371; rs3735059; rs723527; rs6947531; rs7795728; rs2017000; rs6970262; rs887826; rs2302534; rs6964705; rs2740764; rs1861005; rs6593207; rs12673622; rs763317; rs845559; rs11238349; rs11979158; rs845558; rs2241055; rs6593205; rs759169; rs11977388; rs7789965; rs11984267; rs1013127; rs7781264; rs7795743; rs759160; rs1861003; rs4947975; rs11506105; rs741153; rs6947594; rs11238354; rs3823585; rs2293348; rs2740762; rs6957176; rs917881; rs2270247; rs845560; rs11974185; rs10250225; rs12666347; rs10234806; rs7785163; rs6968014; rs2110290; rs2302535; rs11487218; rs2072453; rs9642564; rs12671550; rs1468727; rs7804688; rs7808697; rs1558544; rs13247687; rs759165; rs4947488; rs10244108; rs3800827; rs9642391; rs9692301; rs2075111; rs17172438; rs11770506; rs1558542; rs17337212; rs12669701; rs17335884; rs759166; rs11977757; rs17337353; rs12535536; rs17290336; rs10488141; rs2241054; rs12666182; rs17337289; rs4947983; rs17172431; rs7798980; rs7782830; rs10245472; rs17337331; rs7795564; rs11760406; rs17172450; rs11238353; rs17172455; rs17337233; rs6978771; rs11514996; rs17172446; rs1024750; rs747322; rs11770689; rs7786831; rs7780270; rs845555; rs11278449; rs17336184; rs10280515; rs17172434; rs17335808; rs10251909; rs7796139; rs1815156; rs6969570; rs17336331; rs17289099; rs2041647; rs17172443; rs1468726; rs2075103; rs17172448; rs11979406; rs13244618; rs7781062; rs10488140; rs13224708; rs2692451; rs4947978; rs17336744; rs7803520; rs6960438; rs11978110; rs17289638; rs17335898; rs17586344; rs6593210; rs17337135; rs6954351; rs17336101; rs17289001; rs11981175; rs4947987; rs12538489; rs3778866; rs4947986; rs13234622; rs2006704; rs17289434; rs2472520; rs6952904; rs741152; rs7785141; rs11979255; rs10241451; rs17172452; rs7799627; rs3735062; rs11536635; rs11976696; rs17290110; rs17172445; rs11973394; rs17172428; rs17336919; rs4947971; rs6956366; rs17337107; rs7801956; rs10488142; rs13243364; rs2075106; rs13437685; rs11977299; rs7785013; rs9649769; rs17337360; rs17172432; rs10447908; rs4947984; rs17336709; rs12672027; rs759158; rs11770531; rs17290253; rs17335738; rs17335864; rs7786946; rs17335759; rs6973500; rs4947973; rs7796872; rs17336451; rs1558543; rs17336974; rs6954181; rs17337051; rs17335891; rs17289413; rs4947490; rs2110285; rs17289078; rs10488137; rs12536476; rs17290587; rs12531163; rs12667668; rs17336386; rs17336282; rs10488143; rs747323; rs12535578; rs17336087; rs17172449; rs845556; rs3752651; rs17172430; rs17289672; rs845551; rs17335780; rs13222549; rs759167; rs4947492; rs17172451; rs17290406; rs12668175; rs4947972; rs4947985; rs741151; rs6959438; rs7785313; rs11981529; rs2075102; rs6975226; rs11978754; rs17290580; rs3735063; rs10269512; rs11772801; rs7781774; rs887825; rs11971773; rs17290678; rs17290692; rs1076452; rs12056121; rs12533495; rs17290426; rs12718939; rs11760524; rs1024749; rs6944906; rs17289984; rs17336149; rs11976065; rs11773818; rs10244987; rs4947974; rs3735061; rs17586365; rs17290378; rs11534100; rs17289582; rs12669749; rs11971051; rs7806790; rs10266005; rs12538116; rs10241363; rs17518446; rs13244925; rs7801281; rs729969; rs11974707; rs17337338; rs2041645; rs759159; rs1815157; rs7806891; rs17289725; rs17290489; rs17290033; rs11980828; rs17336493; rs17289274; rs7779645; rs17337121; rs17290301; rs17289907; rs11238352; rs1861002; rs10251695; rs2740761; rs10259974; rs17290183; rs17289533; rs10242263; rs10244468; rs6979102; rs17336352; rs17336577; rs6953397; rs11979536; rs17172436; rs6957999; rs17336310; rs17290552; rs845550; rs17290385; rs845557; rs17336556; rs17290734; rs17289148; rs6964933; rs17290727; rs17290545; rs17337444; rs6957411; rs12673110; rs17289977; rs17337247; rs17172441; rs17172426; rs759168; rs17336849; rs17336059; rs17336233; rs17335982; rs10256152; rs2692456; rs17336688; rs10276261; rs17290155; rs17335919; rs17290197; rs6965663; rs11971253; rs17290713; rs17289760; rs4947976; rs17335912; rs4947982; rs1861004; rs12112020; rs17289700; rs17337465; rs17336017; rs17289343; rs6593202; rs17336598; rs2041646; rs17289134; rs17514740; rs2877261; rs7782501; rs17288994; rs17335878; rs17336765; rs17337346; rs10244020; rs17290274; rs6593209; rs7809394; rs10258683; rs17290524; rs17335773; rs17289197; rs17290629; rs17336542; rs17336912; rs17290117; rs17335850; rs6959843; rs17289596; rs11980564; rs17289781; rs11521100; rs10229932; rs17290399; rs17336940; rs17335905; rs12535226; rs11238350; rs17289693; rs17335940; rs17289015; rs17290706; rs17337521; rs723526; rs1861007; rs17336423; rs17290720; rs6972381; rs17336779; rs17289970; rs2075108; rs17290461; rs7793720; rs17172437; rs17337191; rs17336653; rs17337303; rs17336933; rs17336660; rs17290671; rs17336821; rs17289141; rs4947967; rs11772679; rs17289802; rs17289809; rs17290392; rs17290748; rs17151934; rs4947966; rs17336500; rs11764242; rs10225877; rs17290075; rs17289561; rs9642565; rs737540; rs17289665; rs17290054; rs10273541; rs17289505; rs940813; rs17151952; rs17337268; rs11975526; rs17336031; rs17172435; rs17289232; rs7792218; rs17289575; rs17172425; rs9642393; rs13222385; rs9649847; rs17289746; rs17335961; rs17289512; rs10247160; rs11238346; rs17289043; rs17337310; rs17336080; rs17290741; rs10242779; rs17289385; rs17289991; rs17290246; rs17289092; rs17337114; rs1468724; rs7796081; rs17290061; rs17516612; rs17336205; rs17337296; rs6955125; rs17337493; rs17336024; rs17336254; rs9656703; rs4947988; rs759163; rs17289795; rs17335724; rs4590392; rs17172440; rs4947977; rs17151957; rs17172427; rs17290329; rs17290260; rs17335766; rs2692452; rs845562; rs17337100; rs7785854; rs17335752; rs6972246; rs17336289; rs17290371; rs6593201; rs17290357; rs3735058; rs17336737; rs17288966; rs17335717; rs17289949; rs17289872; rs6965365; rs17335745; rs17290510; rs17336108; rs17290124; rs845553; rs2075104; rs7784002; rs17336926; rs17336814; rs17336136; rs2075105; rs6593208; rs17289371; rs17337065; rs17337486; rs10241364; rs7784148; rs17172429; rs17336870; rs17172433; rs17336751; rs10225911; rs6958497; rs17290176; rs17290468; rs17290308; rs7779644; rs11981148; rs17290650; rs7804404; rs10256573; rs6593197; rs884904; rs759171; rs17335689; rs17288917; rs6965469; rs17335696; rs17335710; rs17290699; rs28929495; rs17336639; rs35515689; rs17337451; rs34352568; rs17337079; rs1140476; rs28384375; rs35918369; rs41321844; rs28384376; rs17289589; rs41494749; rs41396448; rs41420046; rs17337016; rs1063486; rs41522547; rs17290239; rs41499845; rs34043207; rs17337549; rs35473039; rs17290762; rs17288945; rs17337535; rs17337528; rs3807362; rs954311; rs41454444; rs17337009; rs41347952; rs5884404; rs35700282; rs41486949; rs17290755; rs5884400; rs17290350; rs17336198; rs36231681; rs17336177; rs35583802; rs17290267; rs17337177; rs35451379; rs17289788; rs17337500; rs13227565; rs3063039; rs2330950; rs11769870; rs17337324; rs17337030; rs28634290; rs17336212; rs17290503; rs34834666; rs35370311; rs3735060; rs17336191; rs36003468; rs6952965; rs28374832; rs17336947; rs35327977; rs41445246; rs35129851; rs35548632; rs7787051; rs28533424; rs17336863; rs17290664; rs17337205; rs13230678; rs17289554; rs34396811; rs17336226; rs17336619; rs3832476; rs28384374; rs10668776; rs17336338; rs2286962; rs35091605; rs35324931; rs34869938; rs13226762; rs2041648; rs41445047; rs10560613; rs41318645; rs41320254; rs4947965; rs11278025; rs10255899; rs17336400; rs6979667; rs17337149; rs6150121; rs36217273; rs17337282; rs17336772; rs6959684; rs36113077; rs13245120; rs17289851; rs10660950; rs41499254; rs17289914; rs17289456; rs34572421; rs35226721; rs17336612; rs17290287; rs17336570; rs41494445; rs34086818; rs35171442; rs17289392; rs34997281; rs41413244; rs34074299; rs17336472; rs17336967; rs17585650; rs17337128; rs34576937; rs17289225; rs28811354; rs11379797; rs6967929; rs17290068; rs768149; rs36101265; rs17289183; rs17290685; rs17337086; rs17336793; rs41373948; rs41344244; rs41488147; rs41364648; rs6954838; rs34753194; rs36017894; rs34687671; rs17290211; rs17289753; rs17289399; rs13240461; rs17336359; rs35199203; rs35876689; rs13228158; rs17336003; rs10233078; rs17289644; rs17337388; rs36114151; rs41424746; rs17289113; rs17336716; rs3063035; rs17337044; rs34638247; rs17289127; rs2110288; rs34041671; rs17335815; rs17336156; rs34119598; rs28557040; rs36074076; rs12718938; rs35822325; rs13310186; rs17337037; rs17290315; rs17289260; rs17336219; rs5884398; rs41498449; rs17336514; rs10252081; rs7808726; rs35243230; rs17289610; rs34617505; rs11337454; rs41462945; rs10609272; rs17336261; rs35419699; rs36025525; rs17335871; rs718836; rs28421208; rs10240870; rs10081281; rs10618345; rs845549; rs35969369; rs34724121; rs35462899; rs34808391; rs34755969; rs34751800; rs41298767; rs17289169; rs17290482; rs17289295; rs35958465; rs17336115; rs17336891; rs10229098; rs2110286; rs34072530; rs11280908; rs12536919; rs41362846; rs12535614; rs35008934; rs17290040; rs13243914; rs17289617; rs41368044; rs34737166; rs4947969; rs41344849; rs17290475; rs17336591; rs17337458; rs7781757; rs17335947; rs17336416; rs35951148; rs41492046; rs34254662; rs11762067; rs6962134; rs10564333; rs17335933; rs10046549; rs10259122; rs17289085; rs17337479; rs10618989; rs41395746; rs35679531; rs41474451; rs28552843; rs34723095; rs845547; rs17289935; rs17289427; rs11772099; rs17290204; rs5884403; rs11276204; rs17289998; rs41407249; rs17290190; rs17290082; rs17335829; rs41387647; rs41323247; rs36086067; rs17289120; rs2692453; rs28737319; rs35778067; rs10243865; rs1558545; rs17289357; rs17337416; rs34848679; rs34696698; rs35261409; rs35001050; rs41366547; rs17336324; rs17290594; rs34648195; rs10578460; rs4319040; rs34693985; rs34610296; rs17336486; rs5884397; rs17289050; rs17290622; rs28653292; rs17289281; rs17336038; rs3063038; rs17289309; rs17336380; rs4473992; rs17337430; rs2877259; rs10235245; rs17336373; rs34687896; rs35396623; rs17336898; rs1024747; rs11372886; rs17336905; rs35392351; rs17172453; rs41323746; rs13237127; rs35578833; rs7787060; rs41384551; rs17289631; rs17289942; rs17289239; rs17335731; rs17290138; rs28701637; rs36085258; rs17290089; rs10246420; rs36095339; rs17289956; rs17336066; rs17335836; rs2692455; rs845545; rs6969716; rs17289057; rs28505666; rs6967251; rs17336521; rs2472521; rs7784637; rs17289519; rs34118553; rs17289441; rs34720965; rs34101842; rs28444301; rs41341644; rs5015842; rs28704705; rs35450636; rs10241299; rs17290657; rs28728327; rs34022714; rs41421952; rs7789210; rs7787752; rs17290413; rs17289540; rs17289008; rs13234541; rs34807987; rs35633111; rs36002426; rs17336045; rs13237230; rs10543062; rs10631266; rs11405125; rs41491049; rs10225425; rs28384377; rs34139344; rs6970776; rs17289865; rs6947832; rs12718937; rs41446045; rs17336303; rs34580350; rs11396214; rs34059225; rs6954028; rs34783780; rs17288952; rs35892349; rs28683088; rs11381210; rs17289963; rs17337156; rs10227366; rs17337367; rs17289162; rs41323052; rs34619963; rs10540696; rs17288980; rs6948336; rs12667451; rs17290608; rs17290601; rs17336122; rs10650953; rs17288959; rs36045540; rs17289406; rs17336702; rs17336094; rs845548; rs17289204; rs17514371; rs17336884; rs7457993; rs34195760; rs17337374; rs17335989; rs35372285; rs11381480; rs10255134; rs28665309; rs41471148; rs17289624; rs17290096; rs17336247; rs13227700; rs17336275; rs17290026; rs1468725; rs13237226; rs2692450; rs17290454; rs10281594; rs34828355; rs1024745; rs41514345; rs3862854; rs17290420; rs1861006; rs17336366; rs17336646; rs35998188; rs5884402; rs34636342; rs41498945; rs34372589; rs13231202; rs17289568; rs34058394; rs36089840; rs10612331; rs17289211; rs17335794; rs726399; rs34760563; rs6971740; rs4487709; rs17336835; rs28628250; rs2110289; rs17335787; rs41367446; rs41402045; rs35999644; rs35004531; rs41399844; rs17336626; rs34287931; rs35701076; rs12538513; rs34259065; rs11347888; rs17335801; rs17289823; rs5884399; rs17336584; rs7787739; rs17335857; rs36031881; rs17336681; rs845546; rs6979621; rs28535343; rs940805; rs35056953; rs35957527; rs34383437; rs34384206; rs34784599; rs28573307; rs10273937; rs7808366; rs17289739; rs17289477; rs17336877; rs3173671; rs13237124; rs17290573; rs10279672; rs17290538; rs10572386; rs28411673; rs11376505; rs2692454; rs36124211; rs17290322; rs2110287; rs17289830; rs17289879; rs17337514; rs41519650; rs41466248; rs17290531; rs17337219; rs17335843; rs7800174; rs28416308; rs17289658; rs3063036; rs34478523; rs34594044; rs34282985; rs7800086; rs17289651; rs17290615; rs34291121; rs34758031; rs17336393; rs35456043; rs17289218; rs10268378; rs35225821; rs28656910; rs34533759; rs35184439; rs2192293; rs17337058; rs41436451; rs17336674; rs17288910; rs41359546; rs17288924; rs17290771; rs41371445; rs41399446; rs13228815; rs35782780; rs41509446; rs17335682; rs10215371; rs10277070; rs1107616; rs1107617; rs1107618; rs11761161; rs11971997; rs11973011; rs11977625; rs11978031; rs13242110; rs1357973; rs17151964; rs2280653; rs2330949; rs2331013; rs3088198; rs3800826; rs4051; rs4291223; rs6593211; rs6947902; rs6953202; rs6969537; rs7334; rs7776830; rs7784481; rs7790434; rs7792797; rs7809028; rs884419; rs884420; rs940806; rs940807; rs940810; rs940811

# Macromolecular_Interacting_Partner_2_General_References:
6328312; 7654368; 8918811; 9103388; 11161793; 6326261; 6330563; 6093780; 3329716; 1988448; 2991899; 6324343; 3138233; 2985580; 9556602; 6325948; 3039909; 2790960; 2543678; 8962717; 10731668; 11116146

# Macromolecular_Interacting_Partner_2_References:
15947891; 16543718

# Macromolecular_Interacting_Partner_3_ID:
7191

# Macromolecular_Interacting_Partner_3_Name:
Vasopressin-neurophysin 2-copeptin precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
AVP-NPII[Contains: Arg-vasopressin; Neurophysin 2; Neurophysin-II; Copeptin]

# Macromolecular_Interacting_Partner_3_Gene_Name:
AVP

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Vasopressinneurophysin 2copeptin precursor
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCA
DELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGF
HRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
17325

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
4.94

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  neurohypophyseal hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00220:Hormone_4;
PF00184:Hormone_5

# Macromolecular_Interacting_Partner_3_Signals:
1-19

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
340303

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
NEU2_HUMAN (P01185)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
AVP

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
AVP

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:894

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>495 bp
ATGCCTGACACCATGCTGCCCGCCTGCTTCCCTGGCCTACTGGCCTTCTCCTCCGCGTGC
TACTTCCAGAACTGCCCGAGGGGCGGCAAGAGGGCCATGTCCGACCTGGAGCTGAGACAG
TGCCTCCCCTGCGGCCCCGGGGGCAAAGGCCGCTGCTTCGGGCCCAGCATCTGCTGCGCG
GACGAGCTGGGCTGCTTCGTGGGCACGGCTGAGGCGCTGCGCTGCCAGGAGGAGAACTAC
CTGCCGTCGCCCTGCCAGTCCGGCCAGAAGGCGTGCGGGAGCGGGGGCCGCTGCGCCGCC
TTCGGCGTTTGCTGCAACGACGAGAGCTGCGTGACCGAGCCCGAGTGCCGCGAGGGCTTT
CACCGCCGCGCCCGCGCCAGCGACCGGAGCAACGCCACGCAGCTGGACGGGCCGGCCGGG
GCCTTGCTGCTGCGGCTGGTGCAGCTGGCCGGGGCGCCCGAGCCCTTCGAGCCCGCCCAG
CCCGACGCCTACTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
M11166

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_3_Locus:
20p13

# Macromolecular_Interacting_Partner_3_SNPs:
rs5195; rs2282018; rs3787482; rs2740204; rs2770381; rs2740185; rs6037481; rs3761249; rs3729965; rs6115785; rs1887854; rs11697831; rs1051744; rs28934878; rs13041277; rs13041150; rs13041148; rs3729964; rs1051747; rs13041122; rs1051748; rs1051746; rs6115784; rs2740190; rs11482923; rs13037218; rs4815565; rs34852810; rs7362057; rs2770380; rs1410713; rs2740188; rs2740207; rs2740208; rs2740210; rs2770378; rs4813627; rs6037478; rs6051572; rs6051578; rs6084265

# Macromolecular_Interacting_Partner_3_General_References:
2991279; 3768139; 4065330; 1740104; 11780052; 6574452; 7271787; 8370682; 8103767; 8514868; 8045958; 7714110; 8554046; 9360520; 9580132; 9814475; 10369876; 11017955; 11150885; 10677561; 11748489; 11161827; 11980620; 12012274; 12107248; 12359138; 12519420

# Macromolecular_Interacting_Partner_3_References:
15722667; 15951481

# Macromolecular_Interacting_Partner_4_ID:
7197

# Macromolecular_Interacting_Partner_4_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_4_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_4_Locus:
2p23.3

# Macromolecular_Interacting_Partner_4_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_4_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_4_References:
15351948; 15761539; 15764080; 15826924

# Macromolecular_Interacting_Partner_5_ID:
7549

# Macromolecular_Interacting_Partner_5_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
INS

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_5_Signals:
1-24

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
INS

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_5_Locus:
11p15.5

# Macromolecular_Interacting_Partner_5_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_5_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_5_References:
15671919; 16043663; 16139686; 16318400

# Macromolecular_Interacting_Partner_6_ID:
7551

# Macromolecular_Interacting_Partner_6_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_6_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_6_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6p21.3

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_6_References:
15754848; 15853966; 16298263; 17142138

# Macromolecular_Interacting_Partner_7_ID:
7555

# Macromolecular_Interacting_Partner_7_Name:
Fibronectin precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
FN; Cold-insoluble globulin; CIG

# Macromolecular_Interacting_Partner_7_Gene_Name:
FN1

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Fibronectin precursor
MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ
INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI
WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK
PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY
RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP
QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTQGGNSNGALC
HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ
PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP
GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP
LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL
LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG
YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG
TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT
FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP
RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG
VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV
SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT
PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS
DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD
NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA
PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL
IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK
STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV
KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE
SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP
DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA
QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT
SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT
IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL
VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ
KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS
GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGEEIQIGHIPREDVDYHLYP
HGPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLT
GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDE
WERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLG
NGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEP
SPEGTTGQSYNQYSQRYHQRTNTNVNCPIECFMPLDVQADREDSRE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
2386

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
262609

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.42

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00039:fn1;
PF00040:fn2;
PF00041:fn3

# Macromolecular_Interacting_Partner_7_Signals:
1-31

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
12053817

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
FINC_HUMAN (P02751)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
FN1

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
FN1

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:3778

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1929 bp
ATGCTTAGGGGTCCGGGGCCCGGGCTGCTGCTGCTGGCCGTCCAGTGCCTGGGGACAGCG
GTGCCCTCCACGGGAGCCTCGAAGAGCAAGAGGCAGGCTCAGCAAATGGTTCAGCCCCAG
TCCCCGGTGGCTGTCAGTCAAAGCAAGCCCGGTTGTTATGACAATGGAAAACACTATCAG
ATAAATCAACAGTGGGAGCGGACCTACCTAGGCAATGCGTTGGTTTGTACTTGTTATGGA
GGAAGCCGAGGTTTTAACTGCGAGAGTAAACCTGAAGCTGAAGAGACTTGCTTTGACAAG
TACACTGGGAACACTTACCGAGTGGGTGACACTTATGAGCGTCCTAAAGACTCCATGATC
TGGGACTGTACCTGCATCGGGGCTGGGCGAGGGAGAATAAGCTGTACCATCGCAAACCGC
TGCCATGAAGGGGGTCAGTCCTACAAGATTGGTGACACCTGGAGGAGACCACATGAGACT
GGTGGTTACATGTTAGAGTGTGTGTGTCTTGGTAATGGAAAAGGAGAATGGACCTGCAAG
CCCATAGCTGAGAAGTGTTTTGATCATGCTGCTGGGACTTCCTATGTGGTCGGAGAAACG
TGGGAGAAGCCCTACCAAGGCTGGATGATGGTAGATTGTACTTGCCTGGGAGAAGGCAGC
GGACGCATCACTTGCACTTCTAGAAATAGATGCAACGATCAGGACACAAGGACATCCTAT
AGAATTGGAGACACCTGGAGCAAGAAGGATAATCGAGGAAACCTGCTCCAGTGCATCTGC
ACAGGCAACGGCCGAGGAGAGTGGAAGTGTGAGAGGCACACCTCTGTGCAGACCACATCG
AGCGGATCTGGCCCCTTCACCGATGTTCGTGCAGCTGTTTACCAACCGCAGCCTCACCCC
CAGCCTCCTCCCTATGGCCACTGTGTCACAGACAGTGGTGTGGTCTACTCTGTGGGGATG
CAGTGGCTGAAGACACAAGGAAATAAGCAAATGCTTTGCACGTGCCTGGGCAACGGAGTC
AGCTGCCAAGAGACAGCTGTAACCCAGACTTACGGTGGCAACTCAAATGGAGAGCCATGT
GTCTTACCATTCACCTACAACGACAGGACGGACAGCACAACTTCGAATTATGAGCAGGAC
CAGAAATACTCTTTCTGCACAGACCACACTGTTTTGGTTCAGACTCGAGGAGGAAATTCC
AATGGTGCCTTGTGCCACTTCCCCTTCCTATACAACAACCACAATTACACTGATTGCACT
TCTGAGGGCAGAAGAGACAACATGAAGTGGTGTGGGACCACACAGAACTATGATGCCGAC
CAGAAGTTTGGGTTCTGCCCCATGGCTGCCCACGAGGAAATCTGCACAACCAATGAAGGG
GTCATGTACCGCATTGGAGATCAGTGGGATAAGCAGCATGACATGGGTCACATGATGAGG
TGCACGTGTGTTGGGAATGGTCGTGGGGAATGGACATGCATTGCCTACTCGCAGCTTCGA
GATCAGTGCATTGTTGATGACATCACTTACAATGTGAACGACACATTCCACAAGCGTCAT
GAAGAGGGGCACATGCTGAACTGTACATGCTTCGGTCAGGGTCGGGGCAGGTGGAAGTGT
GATCCCGTCGACCAATGCCAGGATTCAGAGACTGGGACGTTTTATCAAATTGGAGATTCA
TGGGAGAAGTATGTGCATGGTGTCAGATACCAGTGCTACTGCTATGGCCGTGGCATTGGG
GAGTGGCATTGCCAACCTTTACAGACCTATCCAAGCTCAAGTGGTCCTGTCGAAGTATTT
ATCACTGAGACTCCGAGTCAGCCCAACTCCCACCCCATCCAGTGGAATGCACCACAGCCA
TCTCACATTTCCAAGTACATTCTCAGGTGGAGACCTGTGAGTATCCCACCCAGAAACCTT
GGATACTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AJ276395

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2q34

# Macromolecular_Interacting_Partner_7_SNPs:
rs6728999; rs17449032; rs1250259; rs1053238; rs7584505; rs13652; rs7596677; rs2289202; rs7589580; rs11651; rs34923683; rs1263; rs1264; rs1250215; rs1250270; rs2289199; rs1250249; rs2692228; rs1250250; rs1250238; rs724617; rs2888354; rs1250248; rs1250240; rs940739; rs1250239; rs1250241; rs1561301; rs1250210; rs1250269; rs7575234; rs1250268; rs7586990; rs10202483; rs10804242; rs7557114; rs7570208; rs1250203; rs1437799; rs2577290; rs7609476; rs6707530; rs10199059; rs1250242; rs2577297; rs1525351; rs7560662; rs6725958; rs2692230; rs7588661; rs1347694; rs7349218; rs2577302; rs1968510; rs12615520; rs10932613; rs6435906; rs1561302; rs13021377; rs6435903; rs7574485; rs6731557; rs1866155; rs1437798; rs1250204; rs6744921; rs7588830; rs10207245; rs7608342; rs2304573; rs7567647; rs4622720; rs6734955; rs1837121; rs2462591; rs13423742; rs3213885; rs13018173; rs13306359; rs2692234; rs10498037; rs7568287; rs1250247; rs1250245; rs940740; rs13432972; rs1975319; rs17517509; rs9288508; rs7560554; rs1250213; rs12466925; rs1898536; rs2577289; rs1437797; rs2289200; rs7594168; rs17457002; rs10172425; rs1250244; rs1437795; rs3796123; rs6709607; rs13004592; rs12105173; rs11693652; rs7575551; rs6435905; rs10498038; rs17457252; rs2372544; rs10201850; rs1250214; rs9288507; rs1250246; rs940738; rs11883812; rs7598634; rs17516906; rs2289198; rs13431081; rs1250258; rs1250201; rs17456939; rs2372545; rs4328631; rs1250243; rs1437796; rs13020766; rs2692224; rs13414859; rs1370561; rs12694363; rs2577298; rs10185587; rs17457029; rs1525352; rs1250211; rs17457391; rs11687442; rs12468524; rs17456054; rs3732355; rs2372542; rs17458018; rs16854055; rs10179882; rs6435904; rs16854041; rs13306373; rs13306365; rs7422428; rs10804241; rs11674123; rs3214671; rs2692223; rs13416478; rs16853839; rs7572169; rs1250212; rs7579867; rs13385786; rs2692227; rs1250256; rs10188325; rs7562453; rs13021679; rs1968509; rs6728950; rs7580800; rs12991003; rs11897708; rs12472383; rs6716361; rs1250264; rs17517928; rs34255697; rs7592898; rs33996776; rs1250267; rs6729052; rs17515300; rs7595740; rs7598545; rs12464459; rs2692222; rs11690611; rs16853986; rs7580569; rs13306364; rs11687611; rs1058361; rs1250209; rs13306372; rs34043251; rs2577301; rs28379061; rs11544109; rs2118413; rs11544105; rs34174607; rs11544106; rs6782; rs35223740; rs35151953; rs35525385; rs2692226; rs35343655; rs13394662; rs34228975; rs10605109; rs10170514; rs34300660; rs13008516; rs35292159; rs28464508; rs35819982; rs34685276; rs35762962; rs17514904; rs35800609; rs1063272; rs2028203; rs1250205; rs11367419; rs5838505; rs35913187; rs34978418; rs1250207; rs7556711; rs2438174; rs36086086; rs7422768; rs10203450; rs7598615; rs10599440; rs35126158; rs5838506; rs5838509; rs36097152; rs28564011; rs10181380; rs5838513; rs16853904; rs9749692; rs6743670; rs41347752; rs9751656; rs13026921; rs35976930; rs35034272; rs10534431; rs34066120; rs34085634; rs34576780; rs13017248; rs10648691; rs5838511; rs1250266; rs1968508; rs1250257; rs10542238; rs10559309; rs11897227; rs1250251; rs34656990; rs2577300; rs13306367; rs10168572; rs13394972; rs3832178; rs34162130; rs11889491; rs35639338; rs2372541; rs28631799; rs34087019; rs34317431; rs35609230; rs34325359; rs7606467; rs10179937; rs10202709; rs34595854; rs35492653; rs34345666; rs35754566; rs9751659; rs35780063; rs5838503; rs13431830; rs1313044; rs6729046; rs6727989; rs35233997; rs34645626; rs7565821; rs10524797; rs5838512; rs2438173; rs36098055; rs34156003; rs1250208; rs35545936; rs5838504; rs10648148; rs1250216; rs11411384; rs11376297; rs36066561; rs1250206; rs1250263; rs7556883; rs3051917; rs1250265; rs35437250; rs35258787; rs10679143; rs7558917; rs13306371; rs12621043; rs4393746; rs35494414; rs16853944; rs34173232; rs34314527; rs5838507; rs11358448; rs2177736; rs34245778; rs10649966; rs10614770; rs2577296; rs34947596; rs10577918; rs9751655; rs33963377; rs13306368; rs16853844; rs16853861; rs34147750; rs2372543; rs11315848; rs5838508; rs11350861; rs1437794; rs35440741; rs6712858; rs5838515; rs5838501; rs11897252; rs34140794; rs13427569; rs13015576; rs5838510; rs35967269; rs35143823; rs2289201; rs34196672; rs10611390; rs13001466; rs6738126; rs7562601; rs13409661; rs6738148; rs5838516; rs13023606; rs10599084; rs28365987; rs35118035; rs10180997; rs1250227; rs1250228; rs1250229; rs1250230; rs1250232; rs1250233; rs1250234; rs1250235; rs1250237; rs12999909; rs13027307; rs2577292; rs2692225; rs3910516; rs4473378; rs6706415; rs6725921; rs6735789; rs7562597; rs7588799; rs7596482; rs7604984

# Macromolecular_Interacting_Partner_7_General_References:
11737888; 3770189; 3031656; 2992939; 3900070; 6462919; 3375063; 2822387; 3478690; 7050098; 6688418; 3003095; 3593230; 2992573; 6200322; 3021206; 12127832; 2989004; 3770201; 4019516; 6304699; 6630202; 3024962; 2414772; 2012601; 1400330; 7989369; 9501082; 1311202; 1423622; 8308892; 7583666; 9514732; 10196121; 10647176; 11285216; 11775745; 12736686; 8120888; 8548820; 10075919

# Macromolecular_Interacting_Partner_7_References:
16876110

# Macromolecular_Interacting_Partner_8_ID:
7556

# Macromolecular_Interacting_Partner_8_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_8_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_8_Signals:
1-18

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_8_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_8_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_8_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_8_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_8_References:
16476848; 16572107; 16671338

# Macromolecular_Interacting_Partner_9_ID:
7297

# Macromolecular_Interacting_Partner_9_Name:
Glucocorticoid receptor

# Macromolecular_Interacting_Partner_9_Synonyms:
GR

# Macromolecular_Interacting_Partner_9_Gene_Name:
NR3C1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Glucocorticoid receptor
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
777

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
85660

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  glucocorticoid receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF02155:GCR;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
31680

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
GCR_HUMAN (P04150)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
NR3C1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
NR3C1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:7978

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>2334 bp
ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
X03225

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_9_Locus:
5q31.3

# Macromolecular_Interacting_Partner_9_SNPs:
rs6192; rs6190; rs6195; rs6196; rs6189; rs6194; rs258751; rs6199; rs6193; rs4912910; rs6191; rs10052957; rs7701443; rs4912909; rs12656106; rs4607376; rs4244032; rs4403203; rs9324924; rs5871845; rs4912911; rs9324922; rs6198; rs10482605; rs10477211; rs13185164; rs13162395; rs4529231; rs4582314; rs4244031; rs10482611; rs10482620; rs12513857; rs6865292; rs4457111; rs9324923; rs4634384; rs11167811; rs6896209; rs4518434; rs12655166; rs10482609; rs4912912; rs10482616; rs11749561; rs13182800; rs10482603; rs10482617; rs10482707; rs17302697; rs10482610; rs10482714; rs4406157; rs7719514; rs17100289; rs6197; rs3806854; rs13186836; rs4518436; rs7723528; rs10482614; rs13170129; rs6882102; rs28364694; rs13153270; rs10482712; rs13155635; rs11747997; rs12653301; rs10043090; rs13184611; rs11167810; rs10482716; rs2301177; rs3806855; rs12054797; rs12515985; rs2918417; rs2918416; rs1866388; rs852980; rs33388; rs258813; rs6188; rs2963156; rs258750; rs852977; rs2918418; rs6877893; rs4986593; rs9324915; rs6866890; rs852982; rs1438732; rs2918419; rs9324914; rs10041520; rs12652915; rs10078410; rs4912905; rs10054283; rs852978; rs864082; rs33389; rs17209251; rs10482625; rs9324916; rs852976; rs10515522; rs2043840; rs10482655; rs2963145; rs9324918; rs12386466; rs11740792; rs11955803; rs9324917; rs2963152; rs9324921; rs4128428; rs10042644; rs258814; rs2118727; rs2398631; rs9324913; rs10482640; rs13355103; rs4912650; rs10482641; rs10482665; rs9324920; rs10482634; rs10482636; rs6871322; rs7716360; rs17100234; rs11745958; rs9324912; rs17339831; rs10482650; rs13358709; rs10482682; rs1438731; rs2963146; rs10515521; rs9324911; rs10482633; rs190488; rs852981; rs10482672; rs10482642; rs10482637; rs13306587; rs852979; rs10482630; rs13176292; rs2918415; rs10066267; rs10482646; rs10482668; rs17100236; rs10482669; rs10482654; rs10482679; rs10482704; rs10076665; rs2963155; rs11740747; rs10482631; rs17209258; rs4912907; rs10482676; rs10482681; rs2918421; rs10482701; rs10482688; rs10482638; rs10482689; rs13360865; rs1837262; rs17339455; rs10482686; rs13360160; rs10482667; rs13353867; rs10072193; rs10071869; rs10038016; rs852975; rs13171962; rs10482700; rs10482643; rs12109552; rs11750172; rs10045381; rs10482658; rs10055443; rs10041957; rs10042903; rs17399352; rs10482626; rs10482653; rs7730946; rs10076037; rs10482675; rs13178847; rs6861962; rs2963151; rs10040972; rs10042897; rs10042042; rs10053679; rs33380; rs10482659; rs2307674; rs3776216; rs10482690; rs13186482; rs10482628; rs10041040; rs13180461; rs2963154; rs12655424; rs9324919; rs10060545; rs10482645; rs1305061; rs11742942; rs3822376; rs34562334; rs10043707; rs10482698; rs10055444; rs10051482; rs10482693; rs10482623; rs10482683; rs17100237; rs13353891; rs13361140; rs10482639; rs2963149; rs10038464; rs860457; rs258747; rs6868190; rs17287758; rs258748; rs17209237; rs33391; rs1800445; rs10482622; rs13306589; rs13306588; rs13160969; rs11292842; rs10482621; rs10482618; rs35515833; rs13166252; rs10482608; rs13173940; rs10482606; rs35257270; rs10477210; rs5871844; rs5871846; rs34113205; rs13306586; rs4585488; rs34519266; rs6187; rs35726834; rs28546630; rs10482619; rs10482612; rs13306585; rs33978809; rs34580792; rs13166717; rs33968115; rs35132206; rs4244033; rs34123577; rs10482711; rs10482706; rs35956102; rs4441905; rs4075426; rs35159833; rs28392717; rs35174661; rs4912908; rs10577951; rs36208514; rs34471178; rs10482708; rs35314635; rs36028129; rs28635164; rs4367320; rs35715139; rs34248080; rs10482613; rs34027900; rs10482709; rs10482713; rs35555700; rs35500391; rs34449288; rs6894830; rs35728985; rs10482710; rs10482604; rs13178409; rs34207899; rs12652149; rs10482607; rs34226461; rs13176328; rs1803634; rs34861052; rs10440742; rs35224915; rs35722527; rs4434414; rs5871847; rs13169606; rs36029993; rs35296125; rs12189168; rs34569272; rs10482615; rs35612073; rs34961947; rs35290813; rs28609103; rs10043662; rs4388235; rs34396341; rs10482715; rs36208517; rs11552272; rs5871843; rs35572256; rs10482657; rs10482691; rs13158118; rs10038827; rs34523349; rs35918104; rs35271349; rs10043423; rs4912906; rs10477206; rs10482661; rs2398628; rs10482678; rs35786621; rs10482677; rs33963148; rs35947578; rs13358784; rs10482680; rs35598337; rs35023410; rs35592572; rs9654496; rs13169116; rs13359753; rs13356889; rs10053963; rs10477207; rs35020221; rs34756958; rs36027185; rs35396295; rs34641849; rs10037525; rs34808627; rs174050; rs2079687; rs34530390; rs10482644; rs3836768; rs28865014; rs4608948; rs34209560; rs10039663; rs10482647; rs10482670; rs10477208; rs860458; rs34841797; rs13169117; rs2963147; rs36008199; rs10042038; rs34427874; rs10482697; rs2963150; rs3861852; rs35245606; rs35176817; rs10062225; rs10477209; rs34535209; rs10482629; rs10073248; rs34319493; rs2022117; rs34780316; rs10482660; rs35624123; rs35302985; rs35299297; rs10482635; rs1140000; rs13306584; rs34194480; rs7715728; rs34260076; rs7734158; rs10482649; rs28822503; rs34638922; rs36090270; rs28453280; rs10045200; rs34152766; rs10482696; rs34346366; rs34743734; rs10055574; rs35527602; rs10035222; rs36010586; rs10037693; rs10482664; rs10482684; rs10482652; rs10482627; rs28821527; rs10482673; rs10482674; rs10482703; rs2963148; rs10060741; rs10482695; rs10053200; rs41423247; rs35655055; rs852974; rs10054713; rs10482624; rs34827388; rs34686112; rs10482692; rs35667604; rs10482694; rs35039262; rs2398629; rs34992369; rs10482687; rs35713866; rs10482685; rs2918420; rs10482666; rs35502804; rs10482648; rs10477204; rs33952897; rs36027730; rs34778988; rs10036278; rs2282800; rs11395012; rs33382; rs10042945; rs13361442; rs10036628; rs35923465; rs35999293; rs35241746; rs10214015; rs4912904; rs10041074; rs6882247; rs28791803; rs10482662; rs10482699; rs34186246; rs34494535; rs35434651; rs10482671; rs10482632; rs10482705; rs13355270; rs33944801; rs34632939; rs2963153; rs33381; rs35507823; rs34176759; rs34763421; rs10482656; rs34340042; rs10482702; rs10065326; rs6873841; rs36105398; rs10482651; rs35696265; rs185434; rs10079976; rs10036734; rs35335992; rs11378193; rs34911720; rs10482663; rs4437403; rs34019216; rs35067504; rs10482717; rs34876003; rs10041406; rs12519083; rs12521436; rs13190019; rs17287745; rs174048; rs258763; rs33383; rs4912913; rs7448383; rs7701582; rs7709864; rs7728835

# Macromolecular_Interacting_Partner_9_General_References:
2867473; 1707881; 2026589; 1958537; 11435610; 3841189; 9154805; 9590696; 10477749; 10566686; 8358712; 10902803; 10866662; 10639135; 11555652; 11238589; 12144530; 12000743; 12415108; 12151000; 12686538; 1704018; 8358735; 8445027; 7683692; 8316249; 9150737; 10391209; 10898924; 11589680; 11344238; 11701741; 11932321; 12050230

# Macromolecular_Interacting_Partner_9_References:
15919070

# Macromolecular_Interacting_Partner_10_ID:
7258

# Macromolecular_Interacting_Partner_10_Name:
Plasminogen activator inhibitor 1 precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
PAI-1; Endothelial plasminogen activator inhibitor; PAI

# Macromolecular_Interacting_Partner_10_Gene_Name:
SERPINE1

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Plasminogen activator inhibitor 1 precursor
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
45061

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
7.22

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_10_Signals:
1-23

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
35272

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
PAI1_HUMAN (P05121)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
SERPINE1

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
SERPINE1

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:8583

# Macromolecular_Interacting_Partner_10_PDB_ID:
1C5G

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>1209 bp
ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA
GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG
AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT
GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG
ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT
CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGACGAGATCAGCACCACAGACGCGATC
TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC
CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT
GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG
GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT
CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC
TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT
GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT
GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG
CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG
TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC
ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC
GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA
TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC
TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG
GAACCCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
X04429

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_10_Locus:
7q21.3-q22

# Macromolecular_Interacting_Partner_10_SNPs:
rs6090; rs6092; rs6091; rs1050813; rs11178; rs7242; rs2227636; rs2227714; rs2227698; rs2227716; rs2227700; rs7241; rs41423845; rs2227695; rs2227639; rs2227645; rs2227635; rs2227696; rs2227644; rs2227637; rs15196; rs2227699; rs1050766; rs2227692; rs2227683; rs2227657; rs2227674; rs2227673; rs2227690; rs2070682; rs2227677; rs2227663; rs2227711; rs2227694; rs2227672; rs2070683; rs2227682; rs2227667; rs2227684; rs2227691; rs2227660; rs2227693; rs1029528; rs2227678; rs2227686; rs2227654; rs2227648; rs2227658; rs2227653; rs2227659; rs2227662; rs2227710; rs2227676; rs2227679; rs6089; rs2227666; rs2227665; rs2227708; rs2227652; rs11976650; rs2227668; rs2227675; rs2227712; rs2227687; rs7788294; rs2227651; rs2227681; rs2227649; rs2227631; rs2227633; rs1050955; rs2227630; rs2227702; rs2227707; rs2227703; rs2227629; rs2227632; rs13306846; rs2227647; rs2227685; rs2227669; rs2227670; rs3177930; rs13306847; rs2854229; rs2227646; rs2854230; rs1801003; rs2227641; rs13230881; rs3209821; rs2227640; rs11553532; rs2227638; rs13306842; rs11553533; rs41334349; rs36228265; rs2227643; rs35674524; rs13306843; rs2227715; rs13306844; rs34950159; rs2227697; rs2227655; rs5886162; rs10274922; rs3020620; rs3071566; rs28503992; rs10563759; rs2227689; rs10249874; rs41281004; rs35391004; rs35447707; rs3020624; rs13306845; rs6959054; rs2227671; rs11279877; rs34817294; rs2227661; rs34814785; rs2227713; rs12535050; rs36172384; rs2227650; rs35467518; rs34384835; rs36051604; rs10600557; rs35764880; rs35459889; rs2227680; rs28460262; rs3020623; rs11409368; rs34132647; rs28695455; rs2854233; rs2227656; rs2854236; rs35399649; rs11375202; rs3020621; rs10265348; rs2227664; rs2227709; rs41432746; rs35952770; rs3020622; rs10577575; rs2527317; rs13240413; rs2227688; rs34472055; rs11272706; rs10563102; rs10582824; rs5886163; rs36227923; rs2227701; rs33997895; rs36228273; rs11553535; rs36114456; rs2227634; rs36228272; rs36228264; rs34857375; rs1799762; rs36228271; rs1799768; rs36228269; rs11416893; rs10228765; rs10243267; rs10281013; rs11560324; rs12534508; rs12536798; rs12540843; rs12673157; rs13238709; rs17135252; rs2227705; rs2854225; rs2854226; rs2854235; rs34144144; rs34699890; rs4727479; rs4729664; rs6465787; rs6950982; rs6956010; rs757716

# Macromolecular_Interacting_Partner_10_General_References:
2430793; 2820474; 3097076; 2612914; 3262512; 3132455; 12853948; 3092219; 3025016; 3026837; 7522053; 11384978; 1731226; 7552714; 9634700; 10368279; 10731421; 9194591; 10391209

# Macromolecular_Interacting_Partner_10_References:
15488878; 15576638; 17142138

# Macromolecular_Interacting_Partner_11_ID:
7570

# Macromolecular_Interacting_Partner_11_Name:
Endothelin-1 precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Preproendothelin-1; PPET1[Contains: Endothelin-1; ET-1; Big endothelin-1]

# Macromolecular_Interacting_Partner_11_Gene_Name:
EDN1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Endothelin1 precursor
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
24425

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.92

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  interaction between organisms
Process:  interspecies interaction between organisms
Process:  symbiosis, encompassing mutualism through parasitism
Process:  pathogenesis
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of organismal physiological process
Process:  regulation of vasoconstriction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Endothelins are endothelium-derived vasoconstrictor peptides

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00322:Endothelin

# Macromolecular_Interacting_Partner_11_Signals:
1-17

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
31255

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
EDN1_HUMAN (P05305)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
EDN1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
EDN1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:3176

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>639 bp
ATGGATTATTTGCTCATGATTTTCTCTCTGCTGTTTGTGGCTTGCCAAGGAGCTCCAGAA
ACAGCAGTCTTAGGCGCTGAGCTCAGCGCGGTGGGTGAGAACGGCGGGGAGAAACCCACT
CCCAGTCCACCCTGGCGGCTCCGCCGGTCCAAGCGCTGCTCCTGCTCGTCCCTGATGGAT
AAAGAGTGTGTCTACTTCTGCCACCTGGACATCATTTGGGTCAACACTCCCGAGCACGTT
GTTCCGTATGGACTTGGAAGCCCTAGGTCCAAGAGAGCCTTGGAGAATTTACTTCCCACA
AAGGCAACAGACCGTGAGAATAGATGCCAATGTGCTAGCCAAAAAGACAAGAAGTGCTGG
AATTTTTGCCAAGCAGGAAAAGAACTCAGGGCTGAAGACATTATGGAGAAAGACTGGAAT
AATCATAAGAAAGGAAAAGACTGTTCCAAGCTTGGGAAAAAGTGTATTTATCAGCAGTTA
GTGAGAGGAAGAAAAATCAGAAGAAGTTCAGAGGAACACCTAAGACAAACCAGGTCGGAG
ACCATGAGAAACAGCGTCAAATCATCTTTTCATGATCCCAAGCTGAAAGGCAAGCCCTCC
AGAGAGCGTTATGTGACCCACAACCGAGCACATTGGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
Y00749

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_11_Locus:
6p24.1

# Macromolecular_Interacting_Partner_11_SNPs:
Not Available

# Macromolecular_Interacting_Partner_11_General_References:
3282927; 2670930; 2659594; 8450044; 14574404; 2649896; 1864385; 9284755; 1515112; 7664037; 1859417; 1736987; 1422154; 7773179; 10231710; 10334806; 10391210

# Macromolecular_Interacting_Partner_11_References:
15808081; 16313806; 16333235; 16915013

# Macromolecular_Interacting_Partner_12_ID:
7577

# Macromolecular_Interacting_Partner_12_Name:
Calcitonin gene-related peptide 1 precursor

# Macromolecular_Interacting_Partner_12_Synonyms:
Calcitonin gene-related peptide I; CGRP-I; Alpha-type CGRP

# Macromolecular_Interacting_Partner_12_Gene_Name:
CALCA

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Calcitonin generelated peptide 1 precursor
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
128

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
13899

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00214:Calc_CGRP_IAPP

# Macromolecular_Interacting_Partner_12_Signals:
1-25

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
179828

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CALCA_HUMAN (P06881)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CALCA

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CALCA

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:1437

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>387 bp
ATGGGCTTCCAAAAGTTCTCCCCCTTCCTGGCTCTCAGCATCTTGGTCCTGTTGCAGGCA
GGCAGCCTCCATGCAGCACCATTCAGGTCTGCCCTGGAGAGCAGCCCAGCAGACCCGGCC
ACGCTCAGTGAGGACGAAGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAG
ATGAAGGCCAGTGAGCTGGAGCAGGAGCAAGAGAGAGAGGGCTCCAGAATCATTGCCCAG
AAGAGAGCCTGTGACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGA
TCAGGGGGTGTGGTGAAGAACAACTTTGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGC
AGGCGCCGCAGGGACCTTCAAGCCTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
M12667

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_12_Locus:
11p15.2-p15.1

# Macromolecular_Interacting_Partner_12_SNPs:
rs13306224; rs5241; rs5239; rs5240; rs5242; rs2956; rs7110615; rs5237; rs5243; rs2644690; rs35815751; rs5238; rs11607133; rs34901084; rs7925191; rs34294892; rs35212698; rs35909067; rs34815547; rs35731970; rs3758761; rs11023401; rs3781719; rs3781718; rs1553005; rs35365543; rs924099; rs11826691; rs11023400; rs34414857; rs34164367; rs34587547; rs34670162; rs2644689; rs35709504; rs35425520; rs7124346; rs2644687; rs34896084; rs35943755; rs35096144; rs2644688; rs13306223; rs2856867; rs34200140; rs35996804; rs35356387; rs34603621; rs34488736; rs35780811; rs2856866; rs1010042; rs12576047; rs34252928; rs2071411; rs7114837; rs34692826; rs7128563; rs28420578; rs12361439; rs34468174; rs13306225; rs11821926; rs1908683; rs34166188; rs35006116; rs35676062; rs35096190; rs12800646; rs35955129; rs35481990; rs28494031; rs34691228; rs12800297; rs12225355; rs12800139; rs34596504; rs1027425; rs1027426; rs1027427; rs10832338; rs11023403; rs11608134; rs11821055; rs11825513; rs11827349; rs1496163; rs1496166; rs16930769; rs16930770; rs16930784; rs17503142; rs763363; rs7929159; rs7948017; rs903808

# Macromolecular_Interacting_Partner_12_General_References:
3872459; 2571128; 6148938; 2408883; 6610687; 3034287; 6609312; 3492492; 1318039; 1988044; 2039456

# Macromolecular_Interacting_Partner_12_References:
16458982

# Macromolecular_Interacting_Partner_13_ID:
7263

# Macromolecular_Interacting_Partner_13_Name:
Small inducible cytokine A2 precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11

# Macromolecular_Interacting_Partner_13_Gene_Name:
CCL2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Small inducible cytokine A2 precursor
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
99

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
11025

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
9.72

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  chemokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane
Component:  extracellular region

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_13_Signals:
1-23

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
307163

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
CCL2_HUMAN (P13500)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
CCL2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
CCL2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:10618

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>300 bp
ATGAAAGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAA
GGGCTCGCTCAGCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAAT
AGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCC
AAAGAAGCTGTGATCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAG
AAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACTTGA


# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
M24545

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_13_Locus:
17q11.2-q12

# Macromolecular_Interacting_Partner_13_SNPs:
rs4586; rs13900; rs2215182; rs2857657; rs3917887; rs28730833; rs2857656; rs2190971; rs2857655; rs3760399; rs3091332; rs3917886; rs11575012; rs11575011; rs3760396; rs13306749; rs13306748; rs13306750; rs41507946; rs3917888; rs34095515; rs3760398; rs11575010; rs2190972; rs36231142; rs3917904; rs1014542; rs3760397; rs1024610; rs1024611; rs1080327; rs11575013; rs11575018; rs11652475; rs11652585; rs11655761; rs11656026; rs11656271; rs11867200; rs11870347; rs17652343; rs1860188; rs1860189; rs1860190; rs1989055; rs2530797; rs2857653; rs2857654; rs3091315; rs3091316; rs3917878; rs3917883; rs3917891; rs3917894; rs3917895; rs4795893; rs4795894; rs6505402; rs7210316; rs7503519; rs8068314; rs8074043; rs8079288; rs991804

# Macromolecular_Interacting_Partner_13_General_References:
2923622; 2513477; 2465924; 2518726; 2357211; 1661560; 8107690; 10918580; 2648385; 2322286; 2071154; 8195247; 8627182; 8898111; 1857712; 8639605; 8989326

# Macromolecular_Interacting_Partner_13_References:
16174286; 16571782

# Macromolecular_Interacting_Partner_14_ID:
7620

# Macromolecular_Interacting_Partner_14_Name:
Natriuretic peptides B precursor [Contains: Gamma-brain natriuretic peptide; Brain natriuretic peptide 32

# Macromolecular_Interacting_Partner_14_Synonyms:
BNP-32]

# Macromolecular_Interacting_Partner_14_Gene_Name:
NPPB

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Natriuretic peptides B precursor Contains: Gammabrain natriuretic peptide; Brain natriuretic peptide 32
MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE
QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRI
SSSSGLGCKVLRRH

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
134

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
14726

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
11.01

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_14_Signals:
1-26

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
179515

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
ANFB_HUMAN (P16860)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
NPPB

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
NPPB

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:7940

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>405 bp
ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCT
TTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACG
TCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAG
CAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGG
GAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCA
CCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATC
AGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M31776

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_14_Locus:
1p36.2

# Macromolecular_Interacting_Partner_14_SNPs:
rs5227; rs5229; rs35628673; rs5228; rs198389; rs198381; rs198388; rs6541007; rs3753581; rs198386; rs549596; rs198387; rs35640285; rs5230; rs35690395; rs13305989; rs35519114; rs35207557; rs35458601; rs3831247; rs34331786; rs13305990; rs616308; rs198380; rs12124640; rs13305991; rs35533748; rs12047640; rs12121986; rs12118667; rs35587340; rs1003632; rs1009591; rs1009592; rs1076626; rs11801879; rs11802855; rs11803049; rs12029160; rs12091159; rs12402363; rs12406089; rs12406383; rs12562819; rs12562952; rs12753716; rs1318408; rs13305986; rs17376426; rs1800773; rs198372; rs198373; rs198375; rs4846061; rs5063; rs5064; rs632793; rs6668352; rs6668659; rs6676300; rs6694164; rs6695740

# Macromolecular_Interacting_Partner_14_General_References:
2597152; 2522777; 2138890; 2136732

# Macromolecular_Interacting_Partner_14_References:
16298263

# Macromolecular_Interacting_Partner_15_ID:
6559

# Macromolecular_Interacting_Partner_15_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_15_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_15_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_15_Locus:
16p11.2

# Macromolecular_Interacting_Partner_15_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_15_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_15_References:
15608389; 15637466; 15699469; 15761031

# Macromolecular_Interacting_Partner_16_ID:
7645

# Macromolecular_Interacting_Partner_16_Name:
Connective tissue growth factor precursor

# Macromolecular_Interacting_Partner_16_Synonyms:
Hypertrophic chondrocyte- specific protein 24

# Macromolecular_Interacting_Partner_16_Gene_Name:
CTGF

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Connective tissue growth factor precursor
MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC
AKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSC
KYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALA
AYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVR
PCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTT
LPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
349

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
38092

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
8.03

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00007:Cys_knot;
PF00219:IGFBP;
PF00090:TSP_1;
PF00093:VWC

# Macromolecular_Interacting_Partner_16_Signals:
1-26

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
180924

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CTGF_HUMAN (P29279)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CTGF

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CTGF

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:2500

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Secreted protein; extracellular space; extracellular matrix. Secreted protein (By similarity)

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>1050 bp
ATGACCGCCGCCAGTATGGGCCCCGTCCGCGTCGCCTTCGTGGTCCTCCTCGCCCTCTGC
AGCCGGCCGGCCGTCGGCCAGAACTGCAGCGGGCCGTGCCGGTGCCCGGACGAGCCGGCG
CCGCGCTGCCCGGCGGGCGTGAGCCTCGTGCTGGACGGCTGCGGCTGCTGCCGCGTCTGC
GCCAAGCAGCTGGGCGAGCTGTGCACCGAGCGCGACCCCTGCGACCCGCACAAGGGCCTC
TTCTGTGACTTCGGCTCCCCGGCCAACCGCAAGATCGGCGTGTGCACCGCCAAAGATGGT
GCTCCCTGCATCTTCGGTGGTACGGTGTACCGCAGCGGAGAGTCCTTCCAGAGCAGCTGC
AAGTACCAGTGCACGTGCCTGGACGGGGCGGTGGGCTGCATGCCCCTGTGCAGCATGGAC
GTTCGTCTGCCCAGCCCTGACTGCCCCTTCCCGAGGAGGGTCAAGCTGCCCGGGAAATGC
TGCGAGGAGTGGGTGTGTGACGAGCCCAAGGACCAAACCGTGGTTGGGCCTGCCCTCGCG
GCTTACCGACTGGAAGACACGTTTGGCCCAGACCCAACTATGATTAGAGCCAACTGCCTG
GTCCAGACCACAGAGTGGAGCGCCTGTTCCAAGACCTGTGGGATGGGCATCTCCACCCGG
GTTACCAATGACAACGCCTCCTGCAGGCTAGAGAAGCAGAGCCGCCTGTGCATGGTCAGG
CCTTGCGAAGCTGACCTGGAAGAGAACATTAAGAAGGGCAAAAAGTGCATCCGTACTCCC
AAAATCTCCAAGCCTATCAAGTTTGAGCTTTCTGGCTGCACCAGCATGAAGACATACCGA
GCTAAATTCTGTGGAGTATGTACCGACGGCCGATGCTGCACCCCCCACAGAACCACCACC
CTGCCGGTGGAGTTCAAGTGCCCTGACGGCGAGGTCATGAAGAAGAACATGATGTTCATC
AAGACCTGTGCCTGCCATTACAACTGTCCCGGAGACAATGACATCTTTGAATCGCTGTAC
TACAGGAAGATGTACGGAGACATGGCATGA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
M92934

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_16_Locus:
6q23.1

# Macromolecular_Interacting_Partner_16_SNPs:
Not Available

# Macromolecular_Interacting_Partner_16_General_References:
1654338; 1293144; 9054739; 14574404; 10614647; 12553878

# Macromolecular_Interacting_Partner_16_References:
15608389; 16723984

# Macromolecular_Interacting_Partner_17_ID:
5991

# Macromolecular_Interacting_Partner_17_Name:
Corticosteroid 11-beta-dehydrogenase isozyme 2

# Macromolecular_Interacting_Partner_17_Synonyms:
11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD- dependent 11-beta-hydroxysteroid dehydrogenase

# Macromolecular_Interacting_Partner_17_Gene_Name:
HSD11B2

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Corticosteroid 11betadehydrogenase isozyme 2
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALS
RLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP
GAIELRTCCSPRLRLLQMDLT
KPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAE
LSPVATFRSCMEVNFFGALELTKGLLPLLRSS
RGRIVTVGSPAGDMPYPCLGAYGTSKA
AVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRK
QLLLANLPQELLQAYG
KDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFI
HYYLP
EGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
405

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
44127

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
9.58

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Lipid transport and metabolism 

# Macromolecular_Interacting_Partner_17_Specific_Function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids

# Macromolecular_Interacting_Partner_17_Pathway:
Not Available

# Macromolecular_Interacting_Partner_17_Reaction:
Not Available

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00106:adh_short

# Macromolecular_Interacting_Partner_17_Signals:
1-21

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 1.1.1.146

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
565082

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
DHI2_HUMAN (P80365)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
HSD11B2

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
HSD11B2

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:5209

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Microsome

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>1218 bp

ATGGAGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCT
GCTGCAGCTGC
TGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGC
TGCTGGCCGCGCTCGACTGGCT
GTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCC
GTGCTGGCCGCCGCCGGCTGGATCGCGTTGTCC
CGCCTGGCGCGCCCGCAGCGCCTGCC
GGTGGCCACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTT
TTGGCAAGGAGACGG
CCAAGAAACTGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAA
CAGC
CCCGGTGCCATCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGAC
CTGACC
AAACCAGGAGACATTAGCCGCTTGCTAGAGTTCACCAAGGCCCACACCACCAG
CACCGGCCTGTGGGGCC
TCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGG
AGCTGTCTCCAGTGGCCACTTTCCGTAG
CTGCATGGAGGTGAATTTCTTTGGCGCGCTC
GAGCTGACCAAGGGCCTCCTGCCCCTGCTGCGCAGCTCA
AGGGGCCGCATCGTGACTGT
GGGGAGCCCAGCGGGGGACATGCCATATCCGTGCTTGGGGGCCTATGGAA
CCTCCAAAG
CGGCCGTGGCGCTACTCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGG
T
CAGCATCATCCAGCCTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGG
GAAAAGCGCAAG
CAATTGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGG
CAAGGACTACATCGAGCACTTGC
ATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGT
CCGACCTCACCCCAGTTGTAGATGCCATCACAGA
TGCGCTGCTGGCAGCTCGGCCCCGC
CGCCGCTATTACCCCGGCCAGGGCCTGGGGCTCATGTACTTCATC
CACTACTACCTGCC
TGAAGGCCTGCGGCGCCGCTTCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTC
GAG
CACTGCAGCCTGGCCAGCCTGGCACTACCCCACCACAGGACGCAGCCCAGGACCCAAACC
TGAGCCC
CGGCCCTTCCCCAGCAGTGGCTCGGTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
U14631

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_17_Locus:
16q22

# Macromolecular_Interacting_Partner_17_SNPs:
rs5479; rs5480; rs9923709; rs13329942; rs17855911; rs28934592; rs28934594; rs13306425; rs17853703; rs28934591; rs28934593; rs1139495; rs2855410; rs5481; rs2549646; rs35257037; rs2855408; rs12935213; rs12919979; rs12934342; rs12934368; rs2549644; rs12935253; rs12919584; rs12934351; rs28464206; rs12933947; rs34076422; rs2549647; rs11413878; rs2549645; rs12934369; rs13306424; rs2855411; rs2855407; rs2549643; rs2549641; rs2855406; rs2911119; rs2855405; rs2549642; rs2925933; rs28373713; rs12918538; rs2911120; rs1053099; rs1053271; rs11860837; rs1213164; rs12596882; rs16957430; rs1802795; rs2279023; rs34389524; rs4360931; rs6499129; rs8056260; rs9922476; rs9922624; rs9936153; rs9936306; rs9940901

# Macromolecular_Interacting_Partner_17_General_References:
7859916; 8530071; 8611140; 11350956; 2889032; 7608290; 7593417; 7670488; 9398712; 9683587; 9661590; 9851783; 9707624; 10489390; 10523339; 11238516

# Macromolecular_Interacting_Partner_17_References:
16109662; 16320254

# Macromolecular_Interacting_Partner_18_ID:
6751

# Macromolecular_Interacting_Partner_18_Name:
Rho-associated protein kinase 1

# Macromolecular_Interacting_Partner_18_Synonyms:
Rho-associated, coiled- coil-containing protein kinase 1; p160 ROCK-1; p160ROCK; Renal carcinoma antigen NY-REN-35

# Macromolecular_Interacting_Partner_18_Gene_Name:
ROCK1

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Rhoassociated protein kinase 1
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD
KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES
NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE
ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
1354

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
158177

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
5.67

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Necessary for apoptotic membrane blebbing. Plays a role in smooth muscle contraction. Required for centromere positioning and centromere- dependent exit from mitosis

# Macromolecular_Interacting_Partner_18_Pathway:
Not Available

# Macromolecular_Interacting_Partner_18_Reaction:
Not Available

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF00130:C1_1;
PF02185:HR1;
PF00169:PH;
PF00069:Pkinase;
PF00433:Pkinase_C;
PF08912:Rho_Binding

# Macromolecular_Interacting_Partner_18_Signals:
None

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
EC 2.7.11.1

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
1276901

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
ROCK1_HUMAN (Q13464)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
ROCK1

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
ROCK1

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:10251

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Cytoplasm. Centrosome; centriole. Golgi apparatus; Golgi apparatus membrane; peripheral membrane protein. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>4065 bp
ATGTCGACTGGGGACAGTTTTGAGACTCGATTTGAAAAAATGGACAACCTGCTGCGGGAT
CCCAAATCGGAAGTGAATTCGGATTGTTTGCTGGATGGATTGGATGCTTTGGTATATGAT
TTGGATTTTCCTGCCTTAAGAAAAAACAAAAATATTGACAACTTTTTAAGCAGATATAAA
GACACAATAAATAAAATCAGAGATTTACGAATGAAAGCTGAAGATTATGAAGTAGTGAAG
GTGATTGGTAGAGGTGCATTTGGAGAAGTTCAATTGGTAAGGCATAAATCCACCAGGAAG
GTATATGCTATGAAGCTTCTCAGCAAATTTGAAATGATAAAGAGATCTGATTCTGCTTTT
TTCTGGGAAGAAAGGGACATCATGGCTTTTGCCAACAGTCCTTGGGTTGTTCAGCTTTTT
TATGCATTCCAAGATGATCGTTATCTCTACATGGTGATGGAATACATGCCTGGTGGAGAT
CTTGTAAACTTAATGAGCAACTATGATGTGCCTGAAAAATGGGCACGATTCTATACTGCA
GAAGTAGTTCTTGCATTGGATGCAATCCATTCCATGGGTTTTATTCACAGAGATGTGAAG
CCTGATAACATGCTGCTGGATAAATCTGGACATTTGAAGTTAGCAGATTTTGGTACTTGT
ATGAAGATGAATAAGGAAGGCATGGTACGATGTGATACAGCGGTTGGAACACCTGATTAT
ATTTCCCCTGAAGTATTAAAATCCCAAGGTGGTGATGGTTATTATGGAAGAGAATGTGAC
TGGTGGTCGGTTGGGGTATTTTTATACGAAATGCTTGTAGGTGATACACCTTTTTATGCA
GATTCTTTGGTTGGAACTTACAGTAAAATTATGAACCATAAAAATTCACTTACCTTTCCT
GATGATAATGACATATCAAAAGAAGCAAAAAACCTTATTTGTGCCTTCCTTACTGACAGG
GAAGTGAGGTTAGGGCGAAATGGTGTAGAAGAAATCAAACGACATCTCTTCTTCAAAAAT
GACCAGTGGGCTTGGGAAACGCTCCGAGACACTGTAGCACCAGTTGTACCCGATTTAAGT
AGTGACATTGATACTAGTAATTTTGATGACTTGGAAGAAGATAAAGGAGAGGAAGAAACA
TTCCCTATTCCTAAAGCTTTCGTTGGCAATCAACTACCTTTTGTAGGATTTACATATTAT
AGCAATCGTAGATACTTATCTTCAGCAAATCCTAATGATAACAGAACTAGCTCCAATGCA
GATAAAAGCTTGCAGGAAAGTTTGCAAAAAACAATCTATAAGCTGGAAGAACAGCTGCAT
AATGAAATGCAGTTAAAAGATGAAATGGAGCAGAAGTGCAGAACCTCAAACATAAAACTA
GACAAGATAATGAAAGAATTGGATGAAGAGGGAAATCAAAGAAGAAATCTAGAATCTACA
GTGTCTCAGATTGAGAAGGAGAAAATGTTGCTACAGCATAGAATTAATGAGTACCAAAGA
AAAGCTGAACAGGAAAATGAGAAGAGAAGAAATGTAGAAAATGAAGTTTCTACATTAAAG
GATCAGTTGGAAGACTTAAAGAAAGTCAGTCAGAATTCACAGCTTGCTAATGAGAAGCTG
TCCCAGTTACAAAAGCAGCTAGAAGAAGCCAATGACTTACTTAGGACAGAATCGGACACA
GCTGTAAGATTGAGGAAGAGTCACACAGAGATGAGCAAGTCAATTAGTCAGTTAGAGTCC
CTGAACAGAGAGTTGCAAGAGAGAAATCGAATTTTAGAGAATTCTAAGTCACAAACAGAC
AAAGATTATTACCAGCTGCAAGCTATATTAGAAGCTGAACGAAGAGACAGAGGTCATGAT
TCTGAGATGATTGGAGACCTTCAAGCTCGAATTACATCTTTACAAGAGGAGGTGAAGCAT
CTCAAACATAATCTCGAAAAAGTGGAAGGAGAAAGAAAAGAGGCTCAAGACATGCTTAAT
CACTCAGAAAAGGAAAAGAATAATTTAGAGATAGATTTAAACTACAAACTTAAATCATTA
CAACAACGGTTAGAACAAGAGGTAAATGAACACAAAGTAACCAAAGCTCGTTTAACTGAC
AAACATCAATCTATTGAAGAGGCAAAGTCTGTGGCAATGTGTGAGATGGAAAAAAAGCTG
AAAGAAGAAAGAGAAGCTCGAGAGAAGGCTGAAAATCGGGTTGTTCAGATTGAGAAACAG
TGTTCCATGCTAGACGTTGATCTGAAGCAATCTCAGCAGAAACTAGAACATTTGACTGGA
AATAAAGAAAGGATGGAGGATGAAGTTAAGAATCTAACCCTGCAACTGGAGCAGGAATCA
AATAAGCGGCTGTTGTTACAAAATGAATTGAAGACTCAAGCATTTGAGGCAGACAATTTA
AAAGGTTTAGAAAAGCAGATGAAACAGGAAATAAATACTTTATTGGAAGCAAAGAGATTA
TTAGAATTTGAGTTAGCTCAGCTTACGAAACAGTATAGAGGAAATGAAGGACAGATGCGG
GAGCTACAAGATCAGCTTGAAGCTGAGCAATATTTCTCGACACTTTATAAAACCCAGGTA
AAGGAACTTAAAGAAGAAATTGAAGAAAAAAACAGAGAAAATTTAAAGAAAATACAGGAA
CTACAAAATGAAAAAGAAACTCTTGCTACTCAGTTGGATCTAGCAGAAACAAAAGCTGAG
TCTGAGCAGTTGGCGCGAGGCCTTCTGGAAGAACAGTATTTTGAATTGACGCAAGAAAGC
AAGAAAGCTGCTTCAAGAAATAGACAAGAGATTACAGATAAAGATCACACTGTTAGTCGG
CTTGAAGAAGCAAACAGCATGCTAACCAAAGATATTGAAATATTAAGAAGAGAGAATGAA
GAGCTAACAGAGAAAATGAAGAAGGCAGAGGAAGAATATAAACTGGAGAAGGAGGAGGAG
ATCAGTAATCTTAAGGCTGCCTTTGAAAAGAATATCAACACTGAACGAACCCTTAAAACA
CAGGCTGTTAACAAATTGGCAGAAATAATGAATCGAAAAGATTTTAAAATTGATAGAAAG
AAAGCTAATACACAAGATTTGAGAAAGAAAGAAAAGGAAAATCGAAAGCTGCAACTGGAA
CTCAACCAAGAAAGAGAGAAATTCAACCAGATGGTAGTGAAACATCAGAAGGAACTGAAT
GACATGCAAGCGCAATTGGTAGAAGAATGTGCACATAGGAATGAGCTTCAGATGCAGTTG
GCCAGCAAAGAGAGTGATATTGAGCAATTGCGTGCTAAACTTTTGGACCTCTCGGATTCT
ACAAGTGTTGCTAGTTTTCCTAGTGCTGATGAAACTGATGGTAACCTCCCAGAGTCAAGA
ATTGAAGGTTGGCTTTCAGTACCAAATAGAGGAAATATCAAACGATATGGCTGGAAGAAA
CAGTATGTTGTGGTAAGCAGCAAAAAAATTTTGTTCTATAATGACGAACAAGATAAGGAG
CAATCCAATCCATCTATGGTATTGGACATAGATAAACTGTTTCACGTTAGACCTGTAACC
CAAGGAGATGTGTATAGAGCTGAAACTGAAGAAATTCCTAAAATATTCCAGATACTATAT
GCAAATGAAGGTGAATGTAGAAAAGATGTAGAGATGGAACCAGTACAACAAGCTGAAAAA
ACTAATTTCCAAAATCACAAAGGCCATGAGTTTATTCCTACACTCTACCACTTTCCTGCC
AATTGTGATGCCTGTGCCAAACCTCTCTGGCATGTTTTTAAGCCACCCCCTGCCCTAGAG
TGTCGAAGATGCCATGTTAAGTGCCACAGAGATCACTTAGATAAGAAAGAGGACTTAATT
TGTCCATGTAAAGTAAGTTATGATGTAACATCAGCAAGAGATATGCTGCTGTTAGCATGT
TCTCAGGATGAACAAAAAAAATGGGTAACTCATTTAGTAAAGAAAATCCCTAAGAATCCA
CCATCTGGTTTTGTTCGTGCTTCCCCTCGAACGCTTTCTACAAGATCCACTGCAAATCAG
TCTTTCCGGAAAGTGGTCAAAAATACATCTGGAAAAACTAGTTAA

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
U43195

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_18_Locus:
18q11.1

# Macromolecular_Interacting_Partner_18_SNPs:
rs1045142; rs1481280; rs6507132; rs8089751; rs394715; rs431765; rs7244299; rs4800118; rs8094619; rs288980; rs1006881; rs7240577; rs2018403; rs7242932; rs7228948; rs720109; rs288985; rs7239317; rs7237677; rs4800119; rs4800367; rs2219950; rs7244278; rs7238386; rs8096762; rs8090088; rs8085654; rs1552110; rs10775457; rs288979; rs288990; rs11876799; rs167029; rs9966660; rs9949153; rs11873648; rs4800112; rs11877741; rs288981; rs1842609; rs4284728; rs11877273; rs17202361; rs17202375; rs6507131; rs9947681; rs17202347; rs2127958; rs11876032; rs7228804; rs9946327; rs8083275; rs9963775; rs9946941; rs8089184; rs9946192; rs9948357; rs16945468; rs10084016; rs7234943; rs12957846; rs8092199; rs9959590; rs8084725; rs12963497; rs8083580; rs8086381; rs4800803; rs288991; rs7407164; rs9952792; rs11876153; rs9950940; rs12454435; rs4095320; rs167030; rs9953703; rs9959737; rs2170343; rs16964623; rs7237099; rs10221433; rs8085504; rs9957177; rs288989; rs412957; rs16945048; rs288982; rs9955908; rs9953184; rs12458373; rs11665272; rs10164253; rs8097942; rs7231120; rs9965597; rs10853665; rs7227454; rs17202368; rs2136423; rs12956671; rs8085986; rs10221439; rs4800927; rs7241868; rs433301; rs16941481; rs9962144; rs9957055; rs427009; rs2663695; rs288986; rs288983; rs11874761; rs6507467; rs3810041; rs13381022; rs35810558; rs2292296; rs35881519; rs2271255; rs2663698; rs16977695; rs10221369; rs34420242; rs35502945; rs12961735; rs35839101; rs35571240; rs34259251; rs34513739; rs34919797; rs35989724; rs11663442; rs28542979; rs12958389; rs28712007; rs288984; rs3907851; rs377629; rs34307576; rs430919; rs28783679; rs2663692; rs188286; rs35993531; rs35231243; rs35001699; rs10594886; rs34205037; rs35541933; rs34539787; rs413304; rs2663699; rs7234154; rs34360056; rs35084641; rs35742013; rs7236166; rs35818888; rs10696723; rs7233330; rs34771086; rs35982785; rs288987; rs182315; rs34374162; rs28688499; rs34724806; rs35680498; rs28460186; rs9951807; rs35559179; rs35918484; rs36022881; rs34175330; rs10699060; rs35635723; rs28596492; rs33983077; rs9964200; rs2663696; rs34526425; rs35120121; rs1552111; rs34855015; rs34525612; rs409223; rs35308483; rs3914052; rs34260822; rs35127623; rs3907852; rs34950642; rs35852910; rs4007699; rs34517512; rs184087; rs191748; rs35477732; rs35101122; rs11876588; rs34530098; rs34422397; rs36048437; rs9945231; rs34217637; rs28805324; rs34178945; rs28554172; rs7228360; rs35855149; rs2663693; rs34675169; rs9966300; rs11334095; rs35799573; rs7231242; rs35473579; rs10552765; rs35778842; rs9955366; rs34128110; rs35069391; rs35371044; rs34251484; rs34153516; rs10468929; rs34394368; rs9962182; rs35484011; rs11420525; rs7233027; rs12955676; rs35843639; rs34825611; rs190836; rs288988; rs9956016; rs12959966; rs9954965; rs34237874; rs28628243; rs35017267; rs34391179; rs34550208; rs28401685; rs8099337; rs34978965; rs34360889; rs185970; rs176396; rs11367017; rs1552112; rs36028960; rs35585248; rs35633449; rs12957585; rs28532370; rs34203914; rs3838904; rs11344426; rs34574242; rs34734770; rs3914053; rs28656187; rs190837; rs34853602; rs12971060; rs34759565; rs11434159; rs35172134; rs35293147; rs16974954; rs34458918; rs8091263; rs34189792; rs7240394; rs35631259; rs35884206; rs8086115; rs34970736; rs35180891; rs35738276; rs12954030; rs33938715; rs35077728; rs34292703; rs36076192; rs36112524; rs34942095; rs420980; rs7243358; rs35353434; rs34934193; rs4414579; rs34310042; rs192624; rs5823294; rs8094951; rs7243774; rs16978270; rs34108991; rs10718814; rs10708353; rs35403307; rs28709741; rs8090829; rs35443203; rs176397; rs34885138; rs8098729; rs35294556; rs35565387; rs34217716; rs12969280; rs188287; rs12955714; rs34945520; rs3907850; rs3914054; rs34641736; rs9955452; rs11387860; rs2663703; rs4007700; rs34499105; rs2663702; rs7237731; rs2663701; rs28667053; rs28536090; rs35996865; rs12607616; rs1275227; rs2555396; rs373153; rs398528

# Macromolecular_Interacting_Partner_18_General_References:
8617235; 10508479; 11283607; 12773565

# Macromolecular_Interacting_Partner_18_References:
16555582

# Macromolecular_Interacting_Partner_19_ID:
7803

# Macromolecular_Interacting_Partner_19_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_19_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_19_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_19_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_19_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_19_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_19_SNPs:
Not Available

# Macromolecular_Interacting_Partner_19_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_19_References:
15872074; 16633090

# Macromolecular_Interacting_Partner_20_ID:
8108

# Macromolecular_Interacting_Partner_20_Name:
Angiotensinogen precursor

# Macromolecular_Interacting_Partner_20_Synonyms:
Serpin A8[Contains: Angiotensin-1; Angiotensin I; Ang I; Angiotensin-2; Angiotensin II; Ang II; Angiotensin-3; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II]

# Macromolecular_Interacting_Partner_20_Gene_Name:
AGT

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Angiotensinogen precursor
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAG
KPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGM
HSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKV
LSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLD
FTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEF
WVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLT
FQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIR
VGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVAN
PLSTA

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
485

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
53155

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
6.27

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  protease inhibitor activity
Function:  endopeptidase inhibitor activity
Function:  serine-type endopeptidase inhibitor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
Angiotensin-3 stimulates aldosterone release

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF00079:Serpin

# Macromolecular_Interacting_Partner_20_Signals:
1-33

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
178640

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
ANGT_HUMAN (P01019)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
AGT

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
AGT

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:333

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>1458 bp
ATGCGGAAGCGAGCACCCCAGTCTGAGATGGCTCCTGCCGGTGTGAGCCTGAGGGCCACC
ATCCTCTGCCTCCTGGCCTGGGCTGGCCTGGCTGCAGGTGACCGGGTGTACATACACCCC
TTCCACCTCGTCATCCACAATGAGAGTACCTGTGAGCAGCTGGCAAAGGCCAATGCCGGG
AAGCCCAAAGACCCCACCTTCATACCTGCTCCAATTCAGGCCAAGACATCCCCTGTGGAT
GAAAAGGCCCTACAGGACCAGCTGGTGCTAGTCGCTGCAAAACTTGACACCGAAGACAAG
TTGAGGGCCGCAATGGTCGGGATGCTGGCCAACTTCTTGGGCTTCCGTATATATGGCATG
CACAGTGAGCTATGGGGCGTGGTCCATGGGGCCACCGTCCTCTCCCCAACGGCTGTCTTT
GGCACCCTGGCCTCTCTCTATCTGGGAGCCTTGGACCACACAGCTGACAGGCTACAGGCA
ATCCTGGGTGTTCCTTGGAAGGACAAGAACTGCACCTCCCGGCTGGATGCGCACAAGGTC
CTGTCTGCCCTGCAGGCTGTACAGGGCCTGCTAGTGGCCCAGGGCAGGGCTGATAGCCAG
GCCCAGCTGCTGCTGTCCACGGTGGTGGGCGTGTTCACAGCCCCAGGCCTGCACCTGAAG
CAGCCGTTTGTGCAGGGCCTGGCTCTCTATACCCCTGTGGTCCTCCCACGCTCTCTGGAC
TTCACAGAACTGGATGTTGCTGCTGAGAAGATTGACAGGTTCATGCAGGCTGTGACAGGA
TGGAAGACTGGCTGCTCCCTGATGGGAGCCAGTGTGGACAGCACCCTGGCTTTCAACACC
TACGTCCACTTCCAAGGGAAGATGAAGGGCTTCTCCCTGCTGGCCGAGCCCCAGGAGTTC
TGGGTGGACAACAGCACCTCAGTGTCTGTTCCCATGCTCTCTGGCATGGGCACCTTCCAG
CACTGGAGTGACATCCAGGACAACTTCTCGGTGACTCAAGTGCCCTTCACTGAGAGCGCC
TGCCTGCTGCTGATCCAGCCTCACTATGCCTCTGACCTGGACAAGGTGGAGGGTCTCACT
TTCCAGCAAAACTCCCTCAACTGGATGAAGAAACTGTCTCCCCGGACCATCCACCTGACC
ATGCCCCAACTGGTGCTGCAAGGATCTTATGACCTGCAGGACCTGCTCGCCCAGGCTGAG
CTGCCCGCCATTCTGCACACCGAGCTGAACCTGCAAAAATTGAGCAATGACCGCATCAGG
GTGGGGGAGGTGCTGAACAGCATTTTTTTTGAGCTTGAAGCGGATGAGAGAGAGCCCACA
GAGTCTACCCAACAGCTTAACAAGCCTGAGGTCTTGGAGGTGACCCTGAACCGCCCATTC
CTGTTTGCTGTGTATGATCAAAGCGCCACTGCCCTGCACTTCCTGGGCCGCGTGGCCAAC
CCGCTGAGCACAGCATGA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
K02215

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_20_Locus:
1q42-q43

# Macromolecular_Interacting_Partner_20_SNPs:
rs11568032; rs699; rs11568053; rs34829218; rs4762; rs11568041; rs2478522; rs5040; rs11568052; rs2004776; rs3789679; rs7539020; rs3789678; rs11568028; rs11568050; rs2493134; rs3889728; rs11568051; rs1078499; rs11568025; rs11568022; rs7539013; rs2148582; rs11568024; rs3827750; rs11568023; rs11568026; rs11122576; rs5050; rs5044; rs11568021; rs11568027; rs11568049; rs11568029; rs11122578; rs11568030; rs5051; rs4753; rs11122577; rs11568031; rs5043; rs5042; rs913147; rs1326883; rs5052; rs7079; rs2478539; rs2493132; rs2493129; rs3789671; rs1926722; rs11568055; rs10864772; rs11568044; rs3789669; rs11568036; rs11568034; rs3789664; rs11568040; rs3789666; rs11568045; rs2478543; rs2478545; rs6687360; rs1926723; rs2493133; rs11568039; rs2478544; rs2493131; rs11122575; rs11568054; rs3827749; rs11568056; rs2493130; rs3789677; rs11568038; rs11568042; rs2478523; rs11568035; rs11568037; rs3789670; rs3789667; rs11568043; rs3789672; rs11568033; rs7543316; rs10864771; rs10864770; rs943580; rs11568048; rs11568014; rs5046; rs6683321; rs7536290; rs2071404; rs5049; rs2067853; rs11568057; rs11568019; rs11568016; rs11122580; rs11122574; rs11568015; rs943581; rs2071406; rs2071405; rs2493136; rs11568018; rs11122573; rs5045; rs11568046; rs5048; rs2478524; rs5047; rs2493135; rs16852352; rs11568017; rs11568020; rs7533803; rs5039; rs1805090; rs5041; rs11557882; rs13306155; rs11557881; rs1803105; rs2229389; rs11557883; rs41271499; rs17856352; rs11557884; rs11557886; rs11557885; rs4029126; rs1803106; rs1803104; rs34099195; rs15022; rs1800585; rs1045464; rs11684; rs35680836; rs1803103; rs35832019; rs28730748; rs34041147; rs34069211; rs35937843; rs12125552; rs13306154; rs3789665; rs35832452; rs34924695; rs34433365; rs36218431; rs10545629; rs10593363; rs34758442; rs5781599; rs11445360; rs34933000; rs36218766; rs1051038; rs10864769; rs10864773; rs12042687; rs12059975; rs12083907; rs12723373; rs12746025; rs1326885; rs1326886; rs1410142; rs1410144; rs1854053; rs2296801; rs2478534; rs2493125; rs2493127; rs2493137; rs3789657; rs3789662; rs4028824; rs4284270; rs4628514; rs4846866; rs7524283; rs7549009; rs7555650; rs9804147

# Macromolecular_Interacting_Partner_20_General_References:
6089875; 2924688; 1692023; 2885106; 3579322; 7259779; 7539791; 4300938; 3934016; 1132082; 9492317; 1394429; 8513325; 7607642; 7744780; 8621667

# Macromolecular_Interacting_Partner_20_References:
15344688; 15492573; 15523303; 15526241

# Macromolecular_Interacting_Partner_21_ID:
8444

# Macromolecular_Interacting_Partner_21_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_21_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_21_Signals:
1-29

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_21_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_21_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_21_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_21_References:
16524053; 16790507

# Macromolecular_Interacting_Partner_22_ID:
8193

# Macromolecular_Interacting_Partner_22_Name:
Atrial natriuretic factor precursor

# Macromolecular_Interacting_Partner_22_Synonyms:
ANF; Atrial natriuretic peptide; ANP; Prepronatriodilatin; CDD-ANF[Contains: Cardiodilatin-related peptide; CDP]

# Macromolecular_Interacting_Partner_22_Gene_Name:
NPPA

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Atrial natriuretic factor precursor
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPP
QVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLT
APRSLRRSSCFGGRMDRIGAQSGLGCNSFRYRR

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
16708

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
7.27

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00212:ANP

# Macromolecular_Interacting_Partner_22_Signals:
1-25

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
178630

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
ANF_HUMAN (P01160)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
NPPA

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
NPPA

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:7939

# Macromolecular_Interacting_Partner_22_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>456 bp
ATGAGCTCCTTCTCCACCACCACCGTGAGCTTCCTCCTTTTACTGGCATTCCAGCTCCTA
GGTCAGACCAGAGCTAATCCCATGTACAATGCCGTGTCCAACGCAGACCTGATGGATTTC
AAGAATTTGCTGGACCATTTGGAAGAAAAGATGCCTTTAGAAGATGAGGTCGTGCCCCCA
CAAGTGCTCAGTGAGCCGAATGAAGAAGCGGGGGCTGCTCTCAGCCCCCTCCCTGAGGTG
CCTCCCTGGACCGGGGAAGTCAGCCCAGCCCAGAGAGATGGAGGTGCCCTCGGGCGGGGC
CCCTGGGACTCCTCTGATCGATCTGCCCTCCTAAAAAGCAAGCTGAGGGCGCTGCTCACT
GCCCCTCGGAGCCTGCGGAGATCCAGCTGCTTCGGGGGCAGGATGGACAGGATTGGAGCC
CAGAGCGGACTGGGCTGTAACAGCTTCCGGTACTGA

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
K02043

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_22_Locus:
1p36.21

# Macromolecular_Interacting_Partner_22_SNPs:
rs5063; rs5065; rs5067; rs5066; rs5068; rs5064; rs198368; rs198367; rs198365; rs198369; rs198366; rs12744433; rs198364; rs198359; rs198358; rs17376426; rs198361; rs198357; rs7552330; rs198372; rs198360; rs198373; rs13305986; rs1803268; rs13305987; rs3170926; rs12565; rs1049827; rs11121835; rs198370; rs12744757; rs35427399; rs41300100; rs12723768; rs41275508; rs41307784; rs6695740; rs35183869; rs5772478; rs17037488; rs1003632; rs12024265; rs1023252; rs11802855; rs12029160; rs12047640; rs12091159; rs12567204; rs14078; rs169158; rs171983; rs17350396; rs198375; rs198381; rs198387; rs198388; rs198402; rs198403; rs198404; rs198405; rs198406; rs198408; rs198409; rs198410; rs198411; rs198412; rs198413; rs198414; rs198415; rs2075538; rs2075539; rs2272802; rs2272803; rs632793; rs6541007; rs6668352; rs6694164; rs7412854

# Macromolecular_Interacting_Partner_22_General_References:
6203042; 6547996; 6095118; 6095119; 6542248; 3158606; 6097248; 6238331; 6230082; 1826098; 8043577

# Macromolecular_Interacting_Partner_22_References:
16212963; 16298263; 16533503

# Macromolecular_Interacting_Partner_23_ID:
8137

# Macromolecular_Interacting_Partner_23_Name:
Mineralocorticoid receptor

# Macromolecular_Interacting_Partner_23_Synonyms:
MR

# Macromolecular_Interacting_Partner_23_Gene_Name:
NR3C2

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Mineralocorticoid receptor
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAI
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
AENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
984

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
107068

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
7.42

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_23_General_Function:
Carbohydrate transport and metabolism 

# Macromolecular_Interacting_Partner_23_Specific_Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
307166

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
MCR_HUMAN (P08235)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
NR3C2

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
NR3C2

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:7979

# Macromolecular_Interacting_Partner_23_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasm. Nucleus. Endoplasmic reticulum; endoplasmic reticulum membrane; peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>2955 bp
ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGT
CAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGGACCTACAGAGAGGACCGATGAGAAT
AACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT
CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGG
CCTGGGATTTTAACATCTGATATTAAAACTGAGCTGGAATCTAAGGAACTTTCAGCAACT
GTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG
CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTG
GTGAAATTTTACAAAGGAAATGGCCATCGTCCTTCCACTCTAAGTTGTGTGAACACGCCC
TTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCATT
GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATG
ACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTCTGTGTCCTCCACCACAGCCAGCTTT
GGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT
GCTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCT
CTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAATTTCCAGCCCTCCAAGTCACTGCAGT
GTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT
GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCC
ACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATCTATCTGTAGCCCTGTAAACAATGCC
TTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC
AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTA
GAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCTTAATATTGTCCAGTACATAAAACCA
GAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT
TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCT
TTTAAAGGGAATCCAACAGTAAACCCGTTTCCATTTATGGATGGCTCGTATTTTTCCTTT
ATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT
GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGACGGG
AGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGCTATTGTTGGGGTGAATTCAGGTGGA
CAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA
GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGG
AAATCACACGGCGACCTGTCGTCTAGAAGAAGTGATGGGTATCCGGTCTTAGAATACATT
CCAGAAAATGTATCAAGCTCTACTTTACGAAGTGTTTCTACTGGATCTTCAAGACCTTCA
AAAATATGTTTGGTGTGTGGGGATGAGGCTTCAGGATGCCATTATGGGGTAGTCACCTGT
GGCAGCTGCAAAGTTTTCTTCAAAAGAGCAGTGGAAGGGCAACACAACTATTTATGTGCT
GGAAGAAATGATTGCATCATTGATAAGATTCGACGAAAGAATTGTCCTGCTTGCAGACTT
CAGAAATGTCTTCAAGCTGGAATGAATTTAGGAGCACGAAAGTCAAAGAAGTTGGGAAAG
TTAAAAGGGATTCACGAGGAGCAGCCACAGCAGCAGCAGCCCCCACCCCCACCCCCACCC
CCGCAAAGCCCAGAGGAAGGGACAACGTACATCGCTCCTGCAAAAGAACCCTCGGTCAAC
ACAGCACTGGTTCCTCAGCTCTCCACAATCTCACGAGCGCTCACACCTTCCCCCGTTATG
GTCCTTGAAAACATTGAACCTGAAATTGTATATGCAGGCTATGACAGCTCAAAACCAGAT
ACAGCCGAAAATCTGCTCTCCACGCTCAACCGCTTAGCAGGCAAACAGATGATCCAAGTC
GTGAAGTGGGCAAAGGTACTTCCAGGATTTAAAAACTTGCCTCTTGAGGACCAAATTACC
CTAATCCAGTATTCTTGGATGTGTCTATCATCATTTGCCTTGAGCTGGAGATCGTACAAA
CATACGAACAGCCAATTTCTCTATTTTGCACCAGACCTAGTCTTTAATGAAGAGAAGATG
CATCAGTCTGCCATGTATGAACTATGCCAGGGGATGCACCAAATCAGCCTTCAGTTCGTT
CGACTGCAGCTCACCTTTGAAGAATACACCATCATGAAAGTTTTGCTGCTACTAAGCACA
ATTCCAAAGGATGGCCTCAAAAGCCAGGCTGCATTTGAAGAAATGAGGACAAATTACATC
AAAGAACTGAGGAAGATGGTAACTAAGTGTCCCAACAATTCTGGGCAGAGCTGGCAGAGG
TTCTACCAACTGACCAAGCTGCTGGACTCCATGCATGACCTGGTGAGCGACCTGCTGGAA
TTCTGCTTCTACACCTTCCGAGAGTCCCATGCGCTGAAGGTAGAGTTCCCCGCAATGCTG
GTGGAGATCATCAGCGACCAGCTGCCCAAGGTGGAGTCGGGGAACGCCAAGCCGCTCTAC
TTCCACCGGAAGTGA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
M16801

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_23_Locus:
4q31.1

# Macromolecular_Interacting_Partner_23_SNPs:
rs5522; rs5527; rs12509135; rs5523; rs13306592; rs5525; rs5529; rs5524; rs5528; rs2070949; rs2871; rs5534; rs7658048; rs5536; rs2070951; rs2070950; rs5530; rs17024360; rs6814934; rs5533; rs5535; rs5537; rs5532; rs6822758; rs1879828; rs1994624; rs1512327; rs1403142; rs1512341; rs1532890; rs1512342; rs2063009; rs1546529; rs1403143; rs907620; rs2137335; rs1546531; rs2137330; rs2163172; rs993386; rs1879829; rs6857487; rs7668847; rs3910047; rs4835514; rs1512329; rs3920217; rs4835479; rs6812904; rs6857011; rs6844155; rs6535594; rs1040288; rs6823544; rs2063556; rs878152; rs3846309; rs11724226; rs6840127; rs10012553; rs7693776; rs6840141; rs10032020; rs4835128; rs1913023; rs11723856; rs6848375; rs6844424; rs3910054; rs2883929; rs4835486; rs10026568; rs7695118; rs12649394; rs4835500; rs6535581; rs2884445; rs3846307; rs7438918; rs13133240; rs9993133; rs6820751; rs1512332; rs6535590; rs6856803; rs3857084; rs11099695; rs4835485; rs3752701; rs12499873; rs3910056; rs6810951; rs3843411; rs6850597; rs11736161; rs10857231; rs3843410; rs2356210; rs9997090; rs6811001; rs6535583; rs3846329; rs3846318; rs4835494; rs1512337; rs10010766; rs4835488; rs6832421; rs907618; rs2048546; rs1858416; rs6535599; rs4835478; rs2272089; rs3846319; rs879206; rs11099690; rs13133379; rs6847959; rs7677409; rs1818448; rs3846302; rs1512344; rs7661835; rs1879827; rs6831376; rs11099680; rs4835490; rs6535580; rs13105361; rs1355613; rs6535597; rs3846306; rs10434100; rs4027073; rs6856424; rs7665528; rs4635799; rs4835516; rs3846317; rs6535598; rs6832393; rs6535584; rs6815984; rs2293162; rs10011595; rs3846322; rs2063555; rs11929719; rs3910044; rs1512343; rs13103641; rs6535577; rs1490453; rs2048547; rs6820304; rs13116347; rs7696770; rs6535579; rs12512126; rs7670229; rs10023128; rs907619; rs6535602; rs4835519; rs3931397; rs2137334; rs7691663; rs6828665; rs2883930; rs907621; rs6825530; rs10519942; rs11099681; rs6828378; rs745019; rs17024708; rs11725509; rs13117325; rs1987969; rs3910052; rs11937655; rs12511893; rs12647605; rs6849127; rs6849903; rs12711259; rs6849862; rs3846316; rs11733930; rs6854515; rs17024387; rs17581884; rs6817983; rs6817925; rs7693171; rs12641471; rs6535588; rs11736713; rs4835133; rs13147775; rs6535593; rs10050229; rs10018805; rs17484259; rs3925570; rs4087964; rs3846328; rs1512326; rs4835508; rs10026226; rs4835506; rs12711260; rs6831034; rs13137823; rs12506077; rs2063554; rs3887856; rs7691250; rs11099679; rs17620160; rs7670069; rs12507494; rs17620330; rs16998733; rs4835491; rs6826213; rs7680420; rs745020; rs12506058; rs11945778; rs17024397; rs6846614; rs13116332; rs9996961; rs4513547; rs17620775; rs6535596; rs12651282; rs3916013; rs12498662; rs10021848; rs3846312; rs11734888; rs10519945; rs992556; rs9631756; rs17484454; rs12499208; rs17483854; rs6816503; rs10519959; rs10034789; rs3846305; rs10004472; rs4594704; rs4087965; rs4260521; rs1546044; rs12640639; rs7694064; rs12508913; rs17620822; rs2358243; rs13112423; rs3846325; rs6831887; rs10031992; rs7698302; rs10519952; rs10031538; rs7694706; rs17581311; rs6826471; rs11735947; rs6826594; rs3911846; rs3910046; rs13150372; rs10519955; rs7683540; rs7673644; rs13137836; rs1512330; rs4835493; rs10434130; rs12642178; rs4087963; rs7655438; rs1398269; rs11728254; rs6813167; rs7698307; rs4835504; rs17024456; rs2137331; rs4835482; rs17024654; rs13119790; rs2883917; rs11732490; rs2063553; rs3846320; rs17483391; rs6857716; rs7670173; rs11733686; rs4579099; rs1996025; rs3843413; rs3846301; rs17620105; rs9997336; rs6851669; rs4835131; rs17484357; rs11946576; rs10519951; rs3733421; rs7683313; rs6839414; rs17484671; rs3910051; rs10024999; rs11099692; rs17483979; rs6855032; rs4083100; rs10519963; rs17024482; rs2063557; rs13142954; rs7693077; rs4835138; rs6814226; rs10031194; rs1522451; rs13146357; rs17484873; rs3910053; rs6831212; rs11099678; rs3846326; rs12331321; rs6834935; rs6825048; rs6813869; rs11724292; rs6823323; rs11731398; rs10519954; rs17483833; rs9991002; rs3857079; rs10033040; rs10032250; rs6849817; rs4835484; rs7661326; rs1512331; rs4835503; rs10519958; rs4835483; rs6535600; rs3910057; rs3846321; rs17484678; rs11730274; rs13116524; rs11737660; rs13144030; rs6818452; rs7699349; rs6836191; rs1512335; rs2358336; rs17024443; rs11726964; rs3846299; rs1429915; rs7672951; rs4835136; rs17024479; rs10002896; rs17024514; rs1911120; rs2137332; rs10519962; rs13123626; rs4835497; rs2115800; rs10026826; rs6836072; rs11099677; rs17024718; rs17484783; rs13116099; rs12639977; rs7670121; rs6819635; rs17024666; rs17582206; rs11721992; rs10857232; rs11943992; rs10025629; rs11932750; rs12511415; rs6813390; rs3846300; rs12510074; rs13118475; rs17024611; rs17484811; rs17024683; rs17024380; rs3857083; rs11933180; rs17024408; rs4835512; rs12506066; rs17580772; rs6836246; rs17582031; rs11099688; rs11730626; rs17024706; rs6849327; rs9761994; rs3846313; rs17483701; rs17485033; rs7666711; rs11731400; rs9762822; rs6846738; rs17024633; rs9685254; rs6857339; rs17024541; rs13129830; rs3910058; rs7668671; rs11099686; rs12500487; rs7673925; rs765491; rs12499901; rs7686433; rs3910060; rs2172002; rs17581262; rs7690849; rs6833880; rs17024678; rs10034882; rs17581570; rs4560389; rs17484839; rs17024631; rs9994262; rs7698917; rs17581787; rs6816918; rs7687754; rs11736341; rs17484118; rs2137336; rs7694200; rs11099689; rs12647354; rs17024704; rs2137333; rs17484622; rs17581815; rs1964691; rs17484447; rs17484245; rs9995951; rs1398268; rs17024437; rs13146865; rs6822617; rs12502713; rs7665347; rs17024516; rs1512336; rs9994862; rs13148853; rs17007968; rs6843485; rs17484601; rs17024518; rs1429914; rs3846323; rs17581905; rs7698289; rs2883879; rs9685269; rs4091074; rs9760992; rs6850820; rs9683768; rs9685938; rs11099694; rs11931777; rs17024512; rs1512334; rs11939588; rs9761239; rs17581605; rs7700126; rs9992964; rs17024364; rs6829058; rs3846308; rs11729617; rs6535592; rs17024509; rs17024506; rs13137095; rs1858415; rs7442442; rs17024717; rs6840422; rs3846310; rs11932031; rs11722863; rs2056471; rs6858581; rs12504040; rs10026186; rs17581220; rs6535578; rs6841404; rs9990620; rs13133487; rs13109933; rs7690778; rs7689925; rs17621119; rs2356374; rs17024579; rs3857082; rs13150785; rs11099683; rs6846591; rs4835487; rs2048548; rs17024720; rs17024469; rs6832062; rs17581975; rs10034617; rs4835502; rs6846217; rs11721799; rs13108130; rs10012907; rs7688969; rs1512328; rs17024715; rs17024681; rs10857233; rs1877445; rs6854045; rs17484063; rs11099687; rs11099685; rs7682972; rs9685272; rs4835505; rs10010607; rs10033445; rs4301087; rs11931989; rs4835513; rs3846304; rs11732130; rs3910059; rs1033123; rs3910055; rs12508062; rs35644313; rs13118022; rs6855341; rs34861534; rs11727894; rs17580954; rs10001430; rs17024404; rs907617; rs17484991; rs7688209; rs12648444; rs17581996; rs12645409; rs1949169; rs6844150; rs6857670; rs11722067; rs3846315; rs13116551; rs17024560; rs11099696; rs7658039; rs11936376; rs878232; rs7698965; rs4835129; rs11725360; rs17024401; rs17024556; rs1980278; rs10009023; rs10434128; rs17376692; rs6856000; rs9995276; rs6841570; rs6842079; rs4835489; rs12509783; rs17676810; rs10519948; rs6853764; rs10011581; rs17581898; rs6851178; rs7690691; rs17581947; rs9998790; rs7692281; rs1522450; rs3857080; rs6854097; rs6846376; rs17483687; rs17024565; rs7674206; rs3910050; rs12506373; rs10029951; rs17581115; rs6812538; rs1873174; rs7696997; rs6836320; rs2301280; rs11936965; rs17024347; rs2248038; rs13306591; rs41511344; rs5526; rs34905604; rs5531; rs6848862; rs35832836; rs35396139; rs6823133; rs10708334; rs12643841; rs1062595; rs35360139; rs35586342; rs10028821; rs11292717; rs1062596; rs34293064; rs2070948; rs34347300; rs35771619; rs17580982; rs28549338; rs34802206; rs34026733; rs35713600; rs35258027; rs35789402; rs35606529; rs3054606; rs11730006; rs34476486; rs10562720; rs13138913; rs35132207; rs5862831; rs4505803; rs7668619; rs34734628; rs3910049; rs11939631; rs13144019; rs34471942; rs28647457; rs28594566; rs28656810; rs11384270; rs34886346; rs13139652; rs34030364; rs1946524; rs10021521; rs7699303; rs33936062; rs34054905; rs13149418; rs11381991; rs34431006; rs6815979; rs34953252; rs7674857; rs17580639; rs35590380; rs34165580; rs35135883; rs11940423; rs34244163; rs35978319; rs17024635; rs13112076; rs3887324; rs1512333; rs28672384; rs35224048; rs9993593; rs35237809; rs35378267; rs35436474; rs981372; rs3857081; rs13104218; rs5862829; rs35681362; rs13121960; rs34159127; rs3843414; rs9631755; rs36034042; rs5862838; rs7699209; rs35201774; rs36182734; rs35264279; rs11378484; rs35714983; rs35933180; rs35464072; rs35423790; rs28605213; rs11930469; rs35186171; rs1522449; rs11332546; rs10605309; rs6822304; rs9762356; rs6829009; rs4501202; rs35976575; rs2137338; rs11381917; rs1522452; rs9997290; rs35907005; rs35562931; rs11416123; rs13108703; rs34987101; rs34152444; rs34611880; rs35337326; rs34236655; rs35111299; rs3846330; rs28441385; rs7679518; rs33937448; rs3846303; rs35282722; rs35595748; rs17620469; rs28377603; rs35809828; rs4027074; rs6839408; rs11733477; rs5862833; rs34529215; rs35563216; rs17024667; rs34997890; rs34279352; rs4835515; rs35480965; rs3846327; rs11944891; rs2293163; rs33971837; rs28379421; rs35496556; rs34440852; rs6826827; rs28698626; rs6852036; rs35126311; rs35152746; rs28465033; rs11361774; rs36135256; rs1946523; rs10026777; rs7678106; rs35607293; rs2115798; rs35549271; rs7680091; rs34975695; rs7682465; rs35198554; rs13112089; rs34530174; rs10034839; rs34469488; rs10716270; rs28805917; rs35947630; rs4447838; rs4835501; rs28372032; rs7678425; rs35095537; rs6815139; rs28367185; rs3843412; rs35190729; rs34364416; rs35944210; rs35557372; rs4835137; rs1355612; rs6535591; rs10003237; rs1546530; rs7673832; rs35827730; rs11362297; rs34296798; rs35058866; rs35315376; rs33962250; rs28798239; rs34298854; rs28698266; rs11349017; rs34206536; rs2356394; rs11725517; rs13132072; rs7691775; rs13137655; rs34453040; rs28639664; rs13111594; rs36012041; rs34621287; rs13434549; rs11386119; rs33973334; rs28723458; rs35806661; rs11099682; rs13108682; rs11935760; rs28837820; rs13132300; rs6815356; rs17024561; rs3045289; rs35258207; rs35591475; rs28702892; rs35992616; rs36196281; rs28604902; rs34170216; rs13137039; rs34489084; rs4295241; rs6819902; rs34825669; rs28462077; rs36032097; rs4621409; rs10434129; rs11723538; rs12641579; rs35653840; rs11343039; rs926019; rs9997923; rs4122853; rs982076; rs13104030; rs35344401; rs12647673; rs13133177; rs35283376; rs35263055; rs6846848; rs6840172; rs28633715; rs6819706; rs35745299; rs34782286; rs5862834; rs5862828; rs7659754; rs7693371; rs35041849; rs6817070; rs12639699; rs34440621; rs36112050; rs34599173; rs28621626; rs11936509; rs10593353; rs35161508; rs35920138; rs3846311; rs35304305; rs34043561; rs28693507; rs4122851; rs28487903; rs13104472; rs9762359; rs35691150; rs13119744; rs11418057; rs34120297; rs11325949; rs965333; rs11326129; rs4026975; rs28869632; rs34643750; rs35003454; rs3846314; rs34966836; rs41510346; rs11444261; rs34113900; rs11303019; rs13138584; rs28482137; rs4027011; rs4293768; rs35554261; rs10528442; rs4835135; rs5862836; rs11459183; rs13118302; rs11440077; rs9992528; rs11323955; rs9654229; rs34090627; rs35633620; rs2102324; rs17304693; rs6838741; rs10586000; rs28789690; rs35476181; rs10654553; rs10624932; rs6833414; rs28645256; rs28834470; rs13132292; rs2358393; rs13139639; rs2358391; rs35101629; rs11724707; rs35649035; rs6831382; rs35957063; rs28367516; rs35414407; rs13105220; rs35574035; rs28408866; rs35013118; rs6535601; rs33924907; rs35672392; rs35706591; rs1033124; rs10023233; rs10025943; rs28377573; rs10650773; rs1911121; rs35087243; rs13104077; rs7670108; rs17024702; rs33913235; rs34874638; rs35954987; rs28663510; rs35637413; rs13120238; rs34771380; rs7678730; rs35697753; rs10008590; rs28593291; rs6535589; rs35210835; rs34273091; rs12507179; rs3053707; rs11363070; rs34012726; rs35945803; rs9993239; rs34416910; rs35504843; rs13145279; rs3927189; rs34311799; rs35146790; rs35181235; rs4835134; rs9992738; rs34374593; rs35318150; rs3752699; rs28588362; rs10607471; rs35749628; rs35992633; rs6854073; rs34815731; rs34799906; rs34810874; rs7668163; rs6535595; rs28711864; rs35264971; rs6814250; rs28369259; rs11940211; rs35083876; rs13144897; rs11320471; rs13127625; rs7438191; rs33955319; rs6148713; rs35899657; rs13129427; rs9994070; rs2137337; rs3910045; rs3045291; rs28408757; rs7375748; rs34408397; rs34019225; rs6852213; rs13136461; rs34980641; rs28802981; rs28542380; rs7661019; rs13132447; rs4835496; rs34189207; rs7685078; rs11365652; rs11947170; rs35303613; rs11324908; rs11731514; rs4613545; rs34201038; rs35227232; rs1039661; rs5862830; rs1913024; rs10019500; rs28886306; rs28505258; rs13123890; rs36193232; rs12650807; rs35870945; rs35700532; rs10050039; rs28376416; rs1057582; rs34880037; rs17024607; rs13149615; rs34890688; rs9994750; rs2884444; rs3857078; rs34704824; rs28648617; rs4122852; rs28612659; rs2356396; rs13104128; rs34636256; rs13136278; rs35441871; rs36048118; rs28657475; rs3846324; rs6823228; rs36084095; rs10857229; rs13107326; rs34499764; rs4027071; rs7670548; rs36145086; rs36150442; rs35832966; rs34625634; rs11330551; rs3041314; rs11363007; rs2115799; rs10648420; rs10008249; rs13142928; rs28464586; rs35591857; rs35550474; rs35903741; rs13146516; rs34946425; rs10564985; rs35545904; rs7377312; rs6854734; rs35593495; rs7668604; rs13119375; rs6818829; rs34936098; rs34272449; rs10434126; rs36036329; rs13112083; rs35000747; rs4611905; rs36084759; rs6827966; rs35940027; rs5862832; rs35659747; rs34400301; rs6831307; rs1512338; rs34618929; rs11324608; rs9999121; rs33928091; rs35667348; rs13109808; rs1506485; rs34896196; rs34217783; rs28407287; rs4835130; rs34576468; rs35162529; rs13133715; rs34220553; rs36127895; rs28368806; rs34718720; rs10593354; rs34580575; rs11727220; rs6854552; rs10026691; rs9995733; rs34168257; rs13115808; rs10608177; rs13134017; rs13103165; rs7438145; rs13106019; rs35504492; rs1512325; rs11384324; rs4560386; rs35925584; rs28696868; rs36041499; rs13137647; rs28897121; rs35642551; rs28507515; rs34868943; rs34430699; rs34051019; rs11722362; rs13132931; rs28622386; rs34346258; rs34696054; rs12511445; rs34317333; rs28391722; rs11386118; rs35741966; rs2356395; rs34642043; rs13109056; rs35311918; rs35979588; rs28529230; rs1429913; rs34163190; rs11335509; rs7656855; rs13104051; rs35367551; rs3045288; rs35932147; rs4835495; rs6839999; rs34372017; rs36114978; rs2358392; rs3906618; rs13125410; rs958785; rs13129690; rs4413384; rs36047772; rs35681147; rs995567; rs34623514; rs35762686; rs3902512; rs6846368; rs9993590; rs35118070; rs13139638; rs2037480; rs34918298; rs35694427; rs7682951; rs6852299; rs35541483; rs28851025; rs28498606; rs35070877; rs2356393; rs35820273; rs34948284; rs2174607; rs34358139; rs6841588; rs35325933; rs13133533; rs1398267; rs34152264; rs3910048; rs34438391; rs6840095; rs35756472; rs13114315; rs11377568; rs35022514; rs1512340; rs35079121; rs28500506; rs28398455; rs12331046; rs10542552; rs34209795; rs5862837; rs35441978; rs10012283; rs28696003; rs35542382; rs11726122; rs34294859; rs35115274; rs35534927; rs28770279; rs35338709; rs34927488; rs6854559; rs10034151; rs28452605; rs5862835; rs28848778; rs28607266; rs3216799; rs13306590; rs885859; rs34063900; rs6834026; rs7672177; rs34064829; rs885858; rs34022568; rs7671250; rs28742132; rs10689483; rs34706003; rs10213471; rs1039662; rs1039663; rs11099676; rs11728788; rs11933330; rs11933380; rs12499434; rs12641566; rs13111300; rs13141425; rs13148438; rs1490464; rs1490465; rs1546043; rs17024337; rs1907076; rs34158761; rs35815539; rs3884525; rs5521; rs6824449; rs7377816; rs906124; rs9307847; rs9724

# Macromolecular_Interacting_Partner_23_General_References:
3037703; 11518808; 9662404; 1655735; 7495694; 9141514; 9392437; 9724527; 10760050; 10935545; 11350956; 10391210; 11134129; 10884226; 12483305

# Macromolecular_Interacting_Partner_23_References:
15361767; 15479953; 15489962; 15511634

# Macromolecular_Interacting_Partner_24_ID:
8258

# Macromolecular_Interacting_Partner_24_Name:
ADM precursor [Contains: Adrenomedullin

# Macromolecular_Interacting_Partner_24_Synonyms:
AM; Proadrenomedullin N-20 terminal peptide; ProAM-N20; ProAM N-terminal 20 peptide; PAMP]

# Macromolecular_Interacting_Partner_24_Gene_Name:
ADM

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>ADM precursor Contains: Adrenomedullin
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVK
AGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKL
AHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGS
APHFL

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
20421

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
11.45

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF02039:Adrenomedullin

# Macromolecular_Interacting_Partner_24_Signals:
1-21

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
500612

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
ADML_HUMAN (P35318)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
ADM

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
ADM

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:259

# Macromolecular_Interacting_Partner_24_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>558 bp
ATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCCTAGGCGCTGAC
ACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGAAGTGGAATAAGTGGGCTCTGAGT
CGTGGGAAGAGGGAACTGCGGATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTGAAG
GCCGGGCCTGCCCAGACCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCC
GAAGACAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCATGAAC
AACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGTGCAGAAGCTG
GCACACCAGATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAG
ATCAGCCCCCAGGGCTACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGT
CGGACTCTGGTGTCTTCTAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGT
GCTCCCCACTTTCTTTAG

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
D14874

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_24_Locus:
11p15.4

# Macromolecular_Interacting_Partner_24_SNPs:
rs5005; rs2228573; rs13306112; rs4698; rs34354539; rs5008; rs35440828; rs13306113; rs5010; rs5002; rs5000; rs11042725; rs35010473; rs5009; rs13306110; rs3814700; rs5004; rs11542824; rs5006; rs34779934; rs1126716; rs35527436; rs34570663; rs5003; rs1126517; rs5007; rs35385980; rs13306111; rs34056369; rs5001; rs34093904; rs11298480; rs11042726; rs11042727; rs11042728; rs11042730; rs12796499; rs1450265; rs1450266; rs1450268; rs17296765; rs2060658; rs4076050; rs4077089; rs4399321; rs4403799; rs4444073; rs4641466; rs4910118; rs7108385; rs7924631; rs7927874; rs7935242; rs7944706; rs9787937

# Macromolecular_Interacting_Partner_24_General_References:
7688224; 8074714; 8387282; 9578982; 10588445

# Macromolecular_Interacting_Partner_24_References:
15361767

# Macromolecular_Interacting_Partner_25_ID:
7752

# Macromolecular_Interacting_Partner_25_Name:
Amiloride-sensitive sodium channel subunit alpha

# Macromolecular_Interacting_Partner_25_Synonyms:
Epithelial Na(+channel subunit alpha; Alpha ENaC; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; Alpha NaCH

# Macromolecular_Interacting_Partner_25_Gene_Name:
SCNN1A

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Amiloridesensitive sodium channel subunit alpha
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
SSTCPLGGP

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
669

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
75704

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  cation channel activity
Function:  sodium channel activity
Function:  amiloride-sensitive sodium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00858:ASC

# Macromolecular_Interacting_Partner_25_Signals:
None

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
86-106
563-583

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
452650

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
SCNNA_HUMAN (P37088)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
SCNN1A

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
SCNN1A

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:10599

# Macromolecular_Interacting_Partner_25_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Note=Apical membrane of epithelial cells

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>2010 bp
ATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTC
ATGAAGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAG
CCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAG
TTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAAC
CGCATGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGG
CAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC
AACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTAC
CCGGAAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGAC
CTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTG
CGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCC
CGTCGAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAG
GACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACA
TACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTG
TCGAGGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTC
GCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTCCACCACCCG
ATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCC
ATGCCTGGAATCAACAACGGTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATT
CCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCC
TTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGG
AAGGAAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGAT
GTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTCCTGC
TTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAG
AACGTGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTC
CAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAGC
GTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAA
TGGGTCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAGAAATGGA
GTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCC
TCTGTCACGATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGC
TCCTCGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATG
TTCCTCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGG
GGTGCTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCAC
CCCATGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCT
CCCCCTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGT
TCCTCCACCTGTCCTCTGGGGGGGCCCTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
X76180

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_25_Locus:
12p13

# Macromolecular_Interacting_Partner_25_SNPs:
rs2228576; rs5742912; rs3741913; rs3764873; rs10849447; rs6489713; rs11614164; rs4764585; rs6489712; rs3764875; rs2286600; rs7972292; rs3741914; rs3782722; rs6489711; rs3782726; rs7976804; rs13306613; rs7973914; rs7968695; rs2041375; rs4764587; rs3782724; rs10849445; rs4764586; rs7296922; rs10849446; rs7956915; rs3764874; rs2364468; rs10774426; rs3782727; rs17725256; rs12304937; rs7958135; rs2534691; rs7972942; rs11064151; rs7963228; rs2534692; rs12581183; rs3782721; rs3782728; rs10774429; rs12579898; rs2886081; rs11064148; rs12322266; rs10774428; rs7957162; rs2532487; rs4491294; rs11064149; rs13306614; rs10774427; rs3782725; rs3782723; rs11064145; rs3759324; rs7297961; rs11831941; rs16932569; rs11608320; rs3759323; rs2071244; rs2364476; rs11833597; rs879605; rs13306616; rs11542844; rs11542843; rs17846607; rs13306619; rs13306618; rs13306617; rs34602363; rs11064150; rs12810735; rs11609789; rs13306621; rs35965494; rs12424134; rs35041216; rs34021000; rs12315455; rs34164551; rs10612411; rs11612314; rs12582338; rs11366729; rs35065658; rs13306620; rs10650761; rs35673511; rs35431612; rs7981003; rs12320672; rs12582636; rs7302949; rs34075843; rs12422366; rs34080023; rs34772874; rs6489714; rs3831763; rs2364473; rs12825322; rs2268008; rs35451673; rs41279086; rs7964163; rs12826912; rs34910948; rs7954060; rs28639508; rs34138854; rs35937239; rs10677875; rs12312293; rs11608322; rs34933785; rs34112282; rs35215657; rs34140670; rs11064152; rs7978675; rs34067413; rs36100233; rs3834495; rs1042318; rs10849448; rs11064153; rs11608700; rs1860545; rs2234649; rs2302256; rs3759333; rs3759334; rs4149570; rs4149573; rs4149576; rs4149577; rs4149578; rs4149579; rs4149580; rs4149581; rs4149621; rs4149622; rs4149623; rs4149626; rs4149627; rs4149629; rs4285931; rs4441073; rs767455

# Macromolecular_Interacting_Partner_25_General_References:
8278374; 8023962; 9654208; 10447117; 9612219; 11266509; 9575806; 9169421; 12167593; 10404817; 10586178

# Macromolecular_Interacting_Partner_25_References:
15673309; 16236820; 16332930; 16613846

# Macromolecular_Interacting_Partner_26_ID:
8324

# Macromolecular_Interacting_Partner_26_Name:
Sodium/hydrogen exchanger 3

# Macromolecular_Interacting_Partner_26_Synonyms:
Na(+/H(+exchanger 3; NHE-3; Solute carrier family 9 member 3

# Macromolecular_Interacting_Partner_26_Gene_Name:
SLC9A3

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Sodium/hydrogen exchanger 3
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIAL
WILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLL
PPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLD
FLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGD
NVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLT
SEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVN
PFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAF
ALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLH
GRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNL
KDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQS
LEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKR
LESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDT
EEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGET
VVPSQRARTQIPYSPGTFRRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
834

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
92909

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  monovalent inorganic cation transporter activity
Function:  hydrogen ion transporter activity
Function:  monovalent cation:proton antiporter activity
Function:  sodium:hydrogen antiporter activity
Function:  transporter activity
Function:  ion transporter activity
Function:  cation transporter activity
Function:  solute:cation antiporter activity
Function:  solute:hydrogen antiporter activity
 ||
>>>
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
Process:  physiological process
Process:  homeostasis
Process:  ion homeostasis
Process:  regulation of pH
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_26_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_26_Specific_Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00999:Na_H_Exchanger

# Macromolecular_Interacting_Partner_26_Signals:
1-25

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
80-99
113-133
140-160
181-202
211-232
253-274
291-309
341-362
370-390
436-456

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
971209

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
SL9A3_HUMAN (P48764)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
SLC9A3

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
SLC9A3

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:11073

# Macromolecular_Interacting_Partner_26_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>2505 bp
ATGTGGGGACTCGGGGCCCGGGGCCCCGACCGGGGGCTGCTGCTGGCGCTGGCGCTGGGC
GGGCTGGCGCGGGCCGGGGGCGTCGAGGTGGAGCCCGGCGGCGCGCACGGCGAGAGCGGG
GGCTTCCAGGTGGTCACCTTCGAGTGGGCCCACGTGCAGGATCCCTACGTCATCGCGCTC
TGGATCCTCGTGGCCAGCTTGGCCAAGATCGGGTTCCACCTGTCCCACAAGGTCACCAGC
GTGGTTCCCGAGAGCGCCCTGCTCATCGTGCTGGGCCTGGTGCTGGGCGGCATCGTCTGG
GCGGCCGACCACATCGCGTCCTTCACACTGACGCCCACCGTCTTCTTCTTCTACCTGCTG
CCCCCCATCGTGCTGGACGCCGGCTACTTCATGCCCAACCGCCTCTTCTTCGGCAACCTG
GGGACCATCCTGTTGTACGCCGTCGTGGGTACCGTGTGGAACGCGGCCACCACCGGGCTG
TCCCTCTACGGCGTCTTCCTCAGTGGGCTCATGGGCGACCTGCAGATTGGGCTGCTGGAC
TTCCTCCTGTTTGGCAGCCTCATGGCGGCTGTGGACCCGGTGGCCGTCCTGGCCGTGTTT
GAGGAGGTCCATGTCAACGAGGTCCTGTTCATCATCGTCTTCGGGGAGTCGCTGCTGAAC
GACGCAGTCACCGTGGTTCTGTACAATGTGTTTGAATCTTTCGTGGCGCTGGGAGGTGAC
AACGTGACTGGCGTGGACTGCGTGAAGGGCATAGTGTCCTTCTTCGTGGTGAGCCTGGGG
GGCACGCTGGTGGGGGTGGTCTTCGCCTTCCTGCTGTCGCTGGTGACGCGCTTCACCAAG
CATGTGCGTATCATCGAGCCCGGCTTCGTGTTCATCATCTCCTACCTGTCCTACCTGACG
TCCGAGATGCTGTCGCTGTCGGCCATCCTCGCCATCACCTTCTGTGGCATCTGCTGTCAG
AAGTATGTGAAGGCCAACATCTCGGAGCAGTCGGCCACCACCGTGCGCTACACCATGAAG
ATGCTGGCCAGCAGCGCCGAGACCATCATCTTCATGTTCCTGGGTATCTCGGCCGTGAAC
CCGTTCATCTGGACCTGGAACACGGCCTTCGTGCTCCTGACGCTGGTCTTCATCTCCGTG
TACCGGGCCATCGGTGTGGTCCTGCAGACCTGGCTTCTGAACCGCTACCGCATGGTGCAG
CTGGAGCCCATTGACCAGGTGGTCCTGTCCTACGGGGGCCTGCGCGGGGCCGTGGCCTTT
GCCCTGGTGGTGCTTCTGGATGGAGACAAGGTCAAGGAGAAGAACCTGTTCGTCAGCACC
ACCATCATCGTAGTGTTCTTCACCGTCATCTTCCAGGGCCTGACCATCAAGCCTCTGGTG
CAGTGGCTGAAGGTGAAGAGGAGCGAGCACCGGGAACCTCGGCTCAACGAGAAGCTGCAC
GGCCGCGCTTTCGACCACATCCTCTCGGCCATCGAGGACATATCCGGACAGATCGGGCAC
AATTATCTCAGAGACAAGTGGTCCCACTTCGACAGGAAGTTCCTCAGCAGGGTCCTCATG
AGACGGTCGGCCCAGAAGTCTCGAGACCGGATCCTGAATGTCTTCCACGAGCTGAACCTG
AAGGATGCCATCAGCTACGTGGCTGAGGGAGAGCGCCGCGGGTCCCTGGCCTTCATCCGC
TCCCCCAGCACCGACAACGTGGTCAACGTGGACTTCACGCCACGATCGTCCACCGTGGAG
GCCTCTGTCTCCTACCTCCTGAGAGAAAATGTCAGCGCTGTCTGCCTGGACATGCAGTCT
CTGGAGCAGCGACGGCGGAGCATCCGGGACGCGGAGGACATGGTCACGCACCACACGCTA
CAGCAGTACCTGTACAAGCCGCGGCAGGAGTACAAGCATCTGTACAGCCGACACGAGCTC
ACGCCCACGGAGGACGAGAAACAGGACCGGGAAATCTTCCACAGGACCATGCGGAAGCGC
CTGGAGTCCTTCAAGTCGACCAAGCTGGGGCTCAACCAGAACAAGAAGGCAGCCAAGCTG
TACAAGCGGGAGCGTGCCCAGAAGCGGAGAAACAGCAGCATCCCCAATGGGAAGCTGCCC
ATGGAGAGCCCTGCGCAGAATTTCACCATCAAGGAGAAAGACTTGGAACTTTCAGACACC
GAGGAGCCCCCCAACTATGATGAGGAGATGAGTGGGGGGATCGAGTTCCTGGCTAGTGTC
ACCAAGGACACAGCGTCCGACTCCCCTGCAGGAATTGACAACCCTGTGTTTTCTCCGGAC
GAGGCCCTGGACCGCAGCCTCCTGGCCAGGCTGCCGCCCTGGCTGTCTCCCGGGGAGACG
GTGGTCCCCTCGCAGAGGGCCCGCACGCAGATTCCCTACTCTCCCGGCACCTTCCGCCGC
CTGATGCCCTTCCGCCTCAGCAGCAAGTCCGTGGACTCCTTCCTGCAGGCAGACGGCCCC
GAGGAGCGGCCCCCCGCCGCCCTCCCCGAGTCCACACACATGTGA

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
U28043

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_26_Locus:
5p15.3

# Macromolecular_Interacting_Partner_26_SNPs:
rs3777231; rs6870920; rs9885312; rs2230437; rs3777230; rs12657631; rs6555316; rs6864158; rs6891049; rs890979; rs10475279; rs4957059; rs2278252; rs3734141; rs6868535; rs10475268; rs12716164; rs890980; rs6891064; rs4345352; rs11748526; rs2241597; rs11746573; rs13165421; rs890985; rs11134081; rs10078774; rs4957061; rs2434389; rs2278254; rs13357643; rs890983; rs11134071; rs9764991; rs6879352; rs2244240; rs890981; rs12716163; rs10475276; rs13158034; rs3777234; rs890978; rs12652789; rs4263057; rs4957045; rs12522575; rs11738544; rs2244223; rs2278247; rs6869648; rs11134082; rs890984; rs925693; rs11134072; rs11134080; rs4956940; rs6555317; rs11740933; rs11743305; rs10475282; rs2247107; rs11134078; rs3777233; rs13436079; rs3756711; rs7443244; rs6872510; rs10462621; rs890977; rs2434377; rs11746373; rs12109836; rs12716166; rs4957043; rs3777226; rs12657794; rs7709376; rs6872583; rs13153157; rs3836908; rs4956947; rs13436080; rs11950405; rs3734137; rs6882664; rs11747348; rs10076162; rs12520842; rs12716167; rs4245971; rs12519017; rs3734139; rs2458820; rs4956949; rs12515615; rs890986; rs6869782; rs7444581; rs10475269; rs12521198; rs11957707; rs10475280; rs11955160; rs3734138; rs11748410; rs4957044; rs6892166; rs2303736; rs4502351; rs6894329; rs9885589; rs6859852; rs4271701; rs13359853; rs10462622; rs3836909; rs7445979; rs17563161; rs6420045; rs2458814; rs1043356; rs12521236; rs6869609; rs13177896; rs890976; rs4956939; rs6879351; rs7721583; rs6555303; rs13356700; rs11950404; rs890982; rs6863511; rs1560173; rs10475283; rs890973; rs1053247; rs13154302; rs41282627; rs3777232; rs34257190; rs41282629; rs36074164; rs34939525; rs35054464; rs34644402; rs10073235; rs34275631; rs11745923; rs4334924; rs28590222; rs7718175; rs34022500; rs35604682; rs28419449; rs12188162; rs36213761; rs35873489; rs10580563; rs7704351; rs7380218; rs4957046; rs10076947; rs35941359; rs12516111; rs5865334; rs34168120; rs10659788; rs34362833; rs13173342; rs11747879; rs7733384; rs33927212; rs4957042; rs11739047; rs13154119; rs36019395; rs35784759; rs34701766; rs34719061; rs12054954; rs11385632; rs34820209; rs34121997; rs34154349; rs41282631; rs10475270; rs6889955; rs34537509; rs10572355; rs7713070; rs11743825; rs4957047; rs33992584; rs938324; rs7378626; rs13170444; rs4957060; rs35227727; rs2303735; rs36161633; rs7725551; rs13359721; rs35697323; rs35710918; rs7445970; rs34406484; rs11950353; rs6555324; rs35600787; rs10078684; rs11338472; rs2458819; rs13360817; rs10053300; rs5865333; rs6888815; rs34293895; rs11741234; rs3734140; rs13168935; rs11955896; rs3211145; rs13152890; rs34562440; rs7736622; rs34834059; rs35878814; rs35145443; rs10062053; rs35346581; rs10065644; rs34033998; rs35159055; rs4520963; rs35051913; rs13186188; rs35858723; rs33925304; rs11954611; rs2721030; rs10475275; rs10551484; rs12188556; rs13174780; rs13359797; rs2303737; rs36083128; rs10475271; rs34004700; rs11385633; rs4956948; rs3832380; rs36124859; rs36160359; rs11747491; rs11956075; rs11269302; rs7735595; rs13181243; rs35715105; rs13189685; rs35671785; rs10067184; rs12109483; rs3214559; rs34590639; rs28619154; rs41282625; rs2278253; rs34160944; rs34358734; rs2303734; rs12110079; rs35004250; rs2560732; rs7700827; rs2672029; rs7723049; rs33997355; rs10073165; rs1035908; rs1035909; rs10474780; rs1053226; rs1053233; rs1053257; rs1053299; rs11169; rs1139706; rs13162508; rs2247114; rs2434695; rs2434697; rs2561667; rs2561676; rs2672028; rs2672032; rs2721014; rs3315; rs36111336; rs3777225; rs3815928; rs3815929; rs3853656; rs3867180; rs3915786; rs4591794; rs4957063; rs6896261; rs699644; rs7726057; rs772659; rs890974

# Macromolecular_Interacting_Partner_26_General_References:
7631746

# Macromolecular_Interacting_Partner_26_References:
16251474; 16543718; 16757729

# Macromolecular_Interacting_Partner_27_ID:
8440

# Macromolecular_Interacting_Partner_27_Name:
Amiloride-sensitive sodium channel subunit gamma

# Macromolecular_Interacting_Partner_27_Synonyms:
Epithelial Na(+channel subunit gamma; Gamma ENaC; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; Gamma NaCH

# Macromolecular_Interacting_Partner_27_Gene_Name:
SCNN1G

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Amiloridesensitive sodium channel subunit gamma
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT
LTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQE
TREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR
KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQ
VPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMG
GSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT
ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAA
NYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWL
LPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMS
CSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDD
DLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
649

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
74271

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
7.54

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  transporter activity
Function:  ion transporter activity
Function:  ion channel activity
Function:  cation channel activity
Function:  sodium channel activity
Function:  amiloride-sensitive sodium channel activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  cation transport
Process:  monovalent inorganic cation transport
Process:  sodium ion transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_27_General_Function:
Not Available

# Macromolecular_Interacting_Partner_27_Specific_Function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00858:ASC

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
56-76
542-562

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
1004273

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
SCNNG_HUMAN (P51170)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
SCNN1G

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
SCNN1G

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:10602

# Macromolecular_Interacting_Partner_27_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Cell membrane; apical cell membrane; multi- pass membrane protein. Note=Apical membrane of epithelial cells

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>1950 bp
ATGGCCCCCGGGGAGAAGATCAAAGCCAAAATCAAGAAGAATCTGCCCGTGACGGGCCCT
CAGGCGCCGACCATTAAAGAGCTGATGCGGTGGTACTGCCTCAACACCAACACCCATGGC
TGTCGCCGCATCGTGGTGTCCCGCGGCCGTCTGCGCCGCCTCCTCTGGATCGGGTTCACA
CTGACTGCCGTGGCCCTCATCCTCTGGCAGTGCGCCCTCCTCGTCTTCTCCTTCTATACT
GTCTCAGTTTCCATCAAAGTCCACTTCCGGAAGCTGGATTTTCCTGCAGTCACCATCTGC
AACATCAACCCCTACAAGTACAGCACCGTTCGCCACCTTCTAGCTGACTTGGAACAGGAG
ACCAGAGAGGCCCTGAAGTCCCTGTATGGCTTTCCAGAGTCCCGGAAGCGCCGAGAGGCG
GAGTCCTGGAACTCCGTCTCAGAGGGAAAGCAGCCTAGATTCTCCCACCGGATTCCGCTG
CTGATCTTTGATCAGGATGAGAAGGGCAAGGCCAGGGACTTCTTCACAGGGAGGAAGCGG
AAAGTCGGCGGTAGCATCATTCACAAGGCTTCAAATGTCATGCACATCGAGTCCAAGCAA
GTGGTGGGATTCCAACTGTGCTCAAATGACACCTCCGACTGTGCCACCTACACCTTCAGC
TCGGGAATCAATGCCATTCAGGAGTGGTATAAGCTACACTACATGAACATCATGGCACAG
GTGCCTCTGGAGAAGAAAATCAACATGAGCTATTCTGCTGAGGAGCTGCTGGTGACCTGC
TTCTTTGATGGAGTGTCCTGTGATGCCAGGAATTTCACGCTTTTCCACCACCCGATGCAT
GGGAATTGCTATACTTTCAACAACAGAGAAAATGAGACCATTCTCAGCACCTCCATGGGG
GGCAGCGAATATGGGCTGCAAGTCATTTTGTACATAAACGAAGAGGAATACAACCCATTC
CTCGTGTCCTCCACTGGAGCTAAGGTGATCATCCATCGGCAGGATGAGTATCCCTCCGTC
GAAGATGTGGGAACAGAGATTGAGACAACAATGGTCACCTCTATAGGAATGCACCTGACA
GAGTCCTTCAAGCTGAGTGAGCCCTCCAGTCAGTGCACGGAGGGCGGGAGTGACGTGCCA
ATCAGGAACATCTACAACGCTGCCTACTCGCTCCAGATCTGCCTTCATTCATGCTTCCAG
ACAAAGATGGTGGAGAAATGTGGGTGTGCCCAGTACAGCCAGCCTCTACCTCCTGCAGCC
AACTACTGCAACTACCAGCAGCACCCCAACTGGATGTATTGTTACTACCAACTGCATCGA
GCCTTTGTCCAGGAAGAGCTGGGCTGCCAGTCTGTGTGCAAGGAAGCCTGCCGCTTTAAA
GAGTGGACACTAACCACAAGCCTGGCACAATGGCCATCTGTGGTTTCGGAGAAGTGGTTG
CTGCCTGTTCTCACTTGGGACCAAGGCCGGCAAGTAAACAAAAAGCTCAACAAGACAGAC
TTGGCCAAACTCTTGATATTCTACAAAGACCTGAACCAGAGATCCATCATGGAGAGCCCA
GCCAACAGTATTGAGATGCTTCTGTCCAACTTCGGCGGTCAGCTGGGCCTGTGGATGAGC
TGCTCTGTTGTCTGCGTCATCGAGATCATCGAGGTCTTCTTCATTGACTTCTTCTCTATC
ATTGCCCGCCGCCAGTGGCAGAAAGCCAAGGAGTGGTGGGCCTGGAAACAGGCTCCCCCA
TGTCCAGAAGCTCCCCGTAGCCCACAGGGCCAGGACAATCCAGCCCTGGATATAGACGAT
GACCTACCCACTTTCAACTCTGCTTTGCACCTGCCTCCAGCCCTAGGAACCCAAGTGCCC
GGCACACCGCCCCCCAAATACAATACCTTGCGCTTGGAGAGGGCCTTTTCCAACCAGCTC
ACAGATACCCAGATGCTGGATGAGCTCTGA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
X87160

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_27_Locus:
16p12

# Macromolecular_Interacting_Partner_27_SNPs:
rs5736; rs5733; rs5738; rs5737; rs5735; rs5723; rs5734; rs16977041; rs4073931; rs4073290; rs7404408; rs4494543; rs5729; rs4073930; rs4073291; rs5728; rs4073289; rs9932505; rs3026; rs5727; rs5730; rs5726; rs9923016; rs5731; rs5732; rs5720; rs5724; rs12934362; rs9922851; rs5722; rs13306657; rs5725; rs5721; rs4302034; rs4328445; rs6497657; rs4260062; rs7200952; rs4516235; rs3922902; rs4247210; rs4486893; rs4335773; rs4281710; rs4470152; rs4499238; rs4341748; rs4297681; rs11643517; rs4967948; rs4347634; rs4309398; rs12708649; rs9941215; rs11649420; rs11643777; rs9931527; rs4407061; rs5740; rs11643416; rs8044686; rs11648257; rs13306653; rs4299163; rs11643449; rs7200183; rs13306654; rs4499239; rs12920681; rs4411498; rs12444767; rs9797088; rs13306665; rs4427805; rs13331086; rs13306659; rs9797083; rs4967991; rs11074553; rs11865345; rs12446988; rs13334616; rs4401050; rs4967949; rs4514682; rs9941210; rs4402571; rs9935983; rs9941128; rs12149898; rs13339277; rs9931080; rs9930846; rs7404738; rs8048419; rs5719; rs12449152; rs5718; rs12449201; rs13306664; rs1126944; rs12447209; rs1126945; rs13306656; rs12149882; rs9926460; rs13306655; rs34120924; rs13306658; rs8043698; rs35147789; rs9924110; rs34281156; rs34993339; rs28534405; rs28525080; rs8063500; rs28414871; rs33931492; rs4132521; rs34606639; rs4967990; rs12930318; rs13335711; rs34293887; rs34396524; rs5816207; rs34549501; rs34689994; rs35214659; rs34477151; rs13335714; rs35249946; rs28377309; rs11642037; rs34977406; rs28674154; rs35779418; rs10532422; rs12927470; rs10716781; rs28571200; rs4620962; rs12924188; rs35750366; rs34518110; rs3922903; rs34749237; rs8060363; rs34665561; rs10532423; rs9630615; rs35192085; rs35065417; rs35090401; rs35869863; rs4620961; rs28524519; rs28565031; rs12919793; rs34514330; rs28521352; rs28440017; rs35242583; rs13335645; rs13335767; rs4405556; rs28608825; rs9937430; rs35352485; rs7498202; rs35864119; rs35288984; rs4132520; rs28514915; rs13332042; rs4967989; rs35523227; rs11309873; rs28368330; rs34258695; rs12149033; rs28586979; rs28415503; rs28504067; rs34802827; rs9938519; rs11643078; rs34243485; rs4511539; rs4577093; rs4967986; rs7202243; rs7206022; rs7500507; rs9922642; rs9927161; rs9928041

# Macromolecular_Interacting_Partner_27_General_References:
7490094; 7762608; 8824247; 7550319; 9169421; 12167593; 10404817; 10391210

# Macromolecular_Interacting_Partner_27_References:
16204229; 16954160

# Macromolecular_Interacting_Partner_28_ID:
8202

# Macromolecular_Interacting_Partner_28_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_28_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_28_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_28_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_28_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_28_Signals:
None

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_28_Locus:
10q22

# Macromolecular_Interacting_Partner_28_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_28_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_28_References:
15511634; 15529592; 15608836; 15834444

# Macromolecular_Interacting_Partner_29_ID:
8446

# Macromolecular_Interacting_Partner_29_Name:
Prostasin precursor

# Macromolecular_Interacting_Partner_29_Synonyms:
Serine protease 8[Contains: Prostasin light chain; Prostasin heavy chain]

# Macromolecular_Interacting_Partner_29_Gene_Name:
PRSS8

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Prostasin precursor
MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
343

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
36432

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
5.72

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Possesses a trypsin-like cleavage specificity

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
Not Available

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_29_Signals:
1-29

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
320-340

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
862305

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
PRSS8_HUMAN (Q16651)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
PRSS8

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
PRSS8

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:9491

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Prostasin:Cell membrane; single-pass membrane protein. Prostasin light chain:Secreted protein; extracellular space. Prostasin heavy chain:Secreted protein; extracellular space. Note=Found in the seminal fluid. Secreted after cleavage of its C-terminus

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>1032 bp
ATGGCCCAGAAGGGGGTCCTGGGGCCTGGGCAGCTGGGGGCTGTGGCCATTCTGCTCTAT
CTTGGATTACTCCGGTCGGGGACAGGAGCGGAAGGGGCAGAAGCTCCCTGCGGTGTGGCC
CCCCAAGCACGCATCACAGGTGGCAGCAGTGCAGTCGCCGGTCAGTGGCCCTGGCAGGTC
AGCATCACCTATGAAGGCGTCCATGTGTGTGGTGGCTCTCTCGTGTCTGAGCAGTGGGTG
CTGTCAGCTGCTCACTGCTTCCCCAGCGAGCACCACAAGGAAGCCTATGAGGTCAAGCTG
GGGGCCCACCAGCTAGACTCCTACTCCGAGGACGCCAAGGTCAGCACCCTGAAGGACATC
ATCCCCCACCCCAGCTACCTCCAGGAGGGCTCCCAGGGCGACATTGCACTCCTCCAACTC
AGCAGACCCATCACCTTCTCCCGCTACATCCGGCCCATCTGCCTCCCTGCAGCCAACGCC
TCCTTCCCCAACGGCCTCCACTGCACTGTCACTGGCTGGGGTCATGTGGCCCCCTCAGTG
AGCCTCCTGACGCCCAAGCCACTGCAGCAACTCGAGGTGCCTCTGATCAGTCGTGAGACG
TGTAACTGCCTGTACAACATCGACGCCAAGCCTGAGGAGCCGCACTTTGTCCAAGAGGAC
ATGGTGTGTGCTGGCTATGTGGAGGGGGGCAAGGACGCCTGCCAGGGTGACTCTGGGGGC
CCACTCTCCTGCCCTGTGGAGGGTCTCTGGTACCTGACGGGCATTGTGAGCTGGGGAGAT
GCCTGTGGGGCCCGCAACAGGCCTGGTGTGTACACTCTGGCCTCCAGCTATGCCTCCTGG
ATCCAAAGCAAGGTGACAGAACTCCAGCCTCGTGTGGTGCCCCAAACCCAGGAGTCCCAG
CCCGACAGCAACCTCTGTGGCAGCCACCTGGCCTTCAGCTCTGCCCCAGCCCAGGGCTTG
CTGAGGCCCATCCTTTTCCTGCCTCTGGGCCTGGCTCTGGGCCTCCTCTCCCCATGGCTC
AGCGAGCACTGA

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
L41351

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_29_Locus:
16p11.2

# Macromolecular_Interacting_Partner_29_SNPs:
rs12597511; rs2855475; rs9972727; rs11645814; rs11558744; rs8049043; rs2550054; rs2550050; rs2855476; rs2550051; rs2550049; rs2550052; rs2855477; rs2550053; rs2550048; rs1047488; rs1060506; rs1549293; rs1549294; rs1549295; rs1549299; rs1549300; rs2550055; rs2550056; rs2855478; rs2855480; rs35208368; rs35319087; rs752148; rs8053474; rs889548; rs9936329

# Macromolecular_Interacting_Partner_29_General_References:
7768952; 8034638

# Macromolecular_Interacting_Partner_29_References:
15549446; 16941024

# Macromolecular_Interacting_Partner_30_ID:
7767

# Macromolecular_Interacting_Partner_30_Name:
E3 ubiquitin-protein ligase NEDD4-like protein

# Macromolecular_Interacting_Partner_30_Synonyms:
Nedd4-2; NEDD4.2

# Macromolecular_Interacting_Partner_30_Gene_Name:
NEDD4L

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>E3 ubiquitinprotein ligase NEDD4like protein
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELAL
VQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP
TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQI
NQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGS
RTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA
GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQL
AEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSP
QPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK
YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY
GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA
VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE
NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI
KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ
FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK
LLMAVENAQGFEGVD

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
975

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
111933

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
5.60

# Macromolecular_Interacting_Partner_30_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-amino acid ligase activity
Function:  ubiquitin-protein ligase activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  cell
Component:  intracellular

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00168:C2;
PF00632:HECT;
PF00397:WW

# Macromolecular_Interacting_Partner_30_Signals:
None

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
12003318

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
NED4L_HUMAN (Q96PU5)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
NEDD4L

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
NEDD4L

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:7728

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>2565 bp
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGA
GTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAA
GAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAA
AAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGG
CACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCC
GAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAAT
ATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCC
AATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGC
AGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGG
AGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACA
TACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCA
GAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCC
AAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAG
CCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAG
ACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCT
TTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTG
CAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATAT
GACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAA
CTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCA
GATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGG
GGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGC
CTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTC
TGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTA
TTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTGGGA
AAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAA
TGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATGTTCTGCATAGACGAAGAAAAC
TTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAAT
GAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAG
AAGCAGATGAACGCATTCTTGGAGGGATTCACAGAACTACTTCCTATTGATTTGATTAAA
ATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTGAAT
GACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAG
TGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAGCGTATCCGGTTACTGCAGTTT
GTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGT
CCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACA
TGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTTGAAGATTTACGAGAGAAACTT
CTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
AF210730

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_30_Locus:
18q21

# Macromolecular_Interacting_Partner_30_SNPs:
rs4149616; rs158862; rs292447; rs1942565; rs497018; rs501370; rs1787777; rs499661; rs158865; rs734779; rs554192; rs2288772; rs569125; rs566032; rs158855; rs2075405; rs2288775; rs158866; rs292455; rs553525; rs504368; rs1787775; rs1787776; rs292449; rs1626076; rs486285; rs1787771; rs479131; rs158868; rs1864921; rs473776; rs483540; rs292457; rs2288774; rs472847; rs292450; rs292444; rs1626887; rs2043265; rs473727; rs565757; rs7240482; rs6566959; rs8094434; rs192659; rs8092749; rs8088164; rs8093462; rs4940665; rs8093302; rs8097018; rs8086848; rs158867; rs4058287; rs6566946; rs471143; rs4941367; rs9944964; rs522155; rs4941377; rs7237429; rs8092871; rs11152059; rs10871753; rs9953409; rs8086835; rs2075403; rs8098126; rs8087052; rs894798; rs8089678; rs4941384; rs4499324; rs6566949; rs571794; rs10513914; rs4340401; rs2105715; rs1942564; rs9957202; rs1005015; rs292451; rs4940387; rs9960278; rs1893480; rs4641835; rs4286186; rs7236804; rs4461163; rs4941382; rs512099; rs4302128; rs4940646; rs547560; rs752124; rs4600541; rs8094453; rs11660589; rs12458921; rs4940679; rs4941366; rs8092556; rs581326; rs8089511; rs8083963; rs9950996; rs9950141; rs1620958; rs8092866; rs1977948; rs4940385; rs9963986; rs4149592; rs7238511; rs1975145; rs9962071; rs1001685; rs8098336; rs3902163; rs4058294; rs4378687; rs4940659; rs4940661; rs6566953; rs7244444; rs4997300; rs485027; rs4941364; rs3865419; rs2075404; rs8090154; rs559840; rs495587; rs4371241; rs4149598; rs6566928; rs4375742; rs7506383; rs9952789; rs1942562; rs2075407; rs4941304; rs574218; rs9949716; rs7229644; rs8084325; rs8087657; rs533502; rs3865420; rs7235554; rs4058288; rs4940671; rs9950709; rs549595; rs4941349; rs12455173; rs8083516; rs7228980; rs1787778; rs579709; rs7239980; rs4419136; rs9948501; rs158856; rs3865414; rs894799; rs9675944; rs6566931; rs2075408; rs2075409; rs1620068; rs497254; rs2586979; rs8083578; rs7230600; rs8085125; rs7242929; rs7243899; rs10871754; rs7236597; rs9957844; rs11152062; rs11661447; rs9955824; rs7232823; rs504904; rs507008; rs476085; rs8098033; rs1573390; rs158857; rs4349234; rs4149601; rs535188; rs11660749; rs12457509; rs7231665; rs7242119; rs8085143; rs4329992; rs6566965; rs4149595; rs7229657; rs8093141; rs1942563; rs4149591; rs6566942; rs4940386; rs4941310; rs563435; rs564442; rs2075406; rs12605388; rs7241969; rs12456898; rs11152060; rs581332; rs4640267; rs4940651; rs7241218; rs571759; rs6566957; rs4940663; rs480230; rs4245310; rs471948; rs538257; rs6566938; rs6566939; rs4528665; rs5005280; rs504098; rs292445; rs7233436; rs563283; rs4940635; rs9962106; rs4058295; rs4941388; rs4940669; rs4149597; rs7231752; rs520210; rs4605249; rs11152065; rs3865415; rs8093609; rs10513913; rs4941348; rs7240603; rs9947545; rs7232273; rs500733; rs490271; rs6566955; rs3744865; rs4940667; rs6566964; rs8086364; rs4591235; rs158861; rs292456; rs4940660; rs9956458; rs11664018; rs9947040; rs182383; rs150385; rs7233294; rs4941378; rs3865418; rs12454098; rs7243662; rs12458971; rs10513916; rs9961411; rs4149605; rs1453082; rs12604234; rs7242486; rs564975; rs1573391; rs12605506; rs1551247; rs4940675; rs894800; rs17232701; rs9953918; rs9963876; rs17064344; rs17064502; rs8091354; rs7243360; rs9959337; rs6566954; rs8084983; rs9966466; rs540101; rs503703; rs520895; rs1008899; rs8092384; rs561126; rs7231823; rs17064338; rs17064589; rs6566940; rs9944723; rs8083107; rs4941312; rs17806239; rs17064925; rs7229171; rs4941389; rs549476; rs17235322; rs17064700; rs7242150; rs12604359; rs1943995; rs7243904; rs6566952; rs569176; rs573880; rs12454023; rs13381636; rs13381932; rs12604734; rs527251; rs17806462; rs576451; rs4149608; rs17833989; rs8085049; rs292443; rs6566933; rs17693592; rs17064800; rs4941375; rs1675; rs8097619; rs4383236; rs10513915; rs10513912; rs963421; rs12457194; rs8088506; rs12967110; rs9949561; rs6566944; rs12458881; rs8082759; rs9959499; rs7239275; rs11874316; rs11662707; rs158858; rs9954721; rs8087212; rs1624292; rs6566958; rs4941380; rs12608075; rs524815; rs13381214; rs7232633; rs513029; rs1975144; rs486997; rs8096809; rs158869; rs7242743; rs17064695; rs7234847; rs559046; rs6566956; rs6566937; rs17693882; rs17064643; rs11152070; rs1562029; rs12605282; rs13380982; rs11661951; rs4149607; rs11663227; rs7235620; rs17693689; rs574890; rs4358024; rs6566961; rs2304021; rs1573389; rs9951962; rs566343; rs17064729; rs9947412; rs9949342; rs11874572; rs9944842; rs4940650; rs11660199; rs7238687; rs17064577; rs4149589; rs4941347; rs4941379; rs536545; rs12606138; rs11664614; rs7236126; rs2051306; rs550737; rs6566951; rs12965133; rs3816005; rs13381620; rs6566935; rs552456; rs11664416; rs12051934; rs10513911; rs11663290; rs536222; rs11152064; rs11662225; rs292453; rs292448; rs9954295; rs7241822; rs1977947; rs2586982; rs878396; rs12455563; rs525839; rs12454199; rs9959537; rs3809969; rs4257288; rs8088201; rs1943994; rs732796; rs10503022; rs17064591; rs1573388; rs522864; rs4941383; rs7231348; rs513111; rs4149593; rs577837; rs12606637; rs6566941; rs7238829; rs6566934; rs12953449; rs12956511; rs9945040; rs9954157; rs482805; rs9965250; rs11152069; rs9955907; rs3852853; rs8094327; rs12456509; rs17064331; rs8091185; rs12373506; rs12457076; rs9964793; rs9948710; rs506784; rs7242074; rs529478; rs7230356; rs474743; rs6566943; rs9960869; rs7227501; rs11663936; rs4941332; rs4941373; rs9965270; rs8082897; rs12605327; rs7243164; rs8090150; rs10503020; rs11664664; rs559475; rs530899; rs9956206; rs4149609; rs8087044; rs17064669; rs4940677; rs4940662; rs9950627; rs11663320; rs11662999; rs4940647; rs2304020; rs502450; rs17064340; rs513563; rs8089173; rs1672; rs10439056; rs12960965; rs17064520; rs495437; rs557238; rs11660397; rs17064916; rs9965182; rs4940678; rs543347; rs3809967; rs571730; rs4941386; rs11152066; rs7244473; rs560894; rs6566962; rs17064378; rs4455056; rs7235668; rs11663307; rs572064; rs7235727; rs7235598; rs7240964; rs17064918; rs9989611; rs2586983; rs7239316; rs7232059; rs12959070; rs2083861; rs4941339; rs8094889; rs17064747; rs8096096; rs17064854; rs526730; rs7241583; rs8085142; rs8089275; rs4072562; rs9285377; rs9946135; rs2602167; rs4940657; rs12968965; rs7233421; rs7242102; rs576416; rs7229083; rs12456657; rs8091333; rs17064830; rs4940643; rs7243384; rs9807396; rs12605830; rs571570; rs12327065; rs8085894; rs12966139; rs531896; rs17064859; rs9959036; rs8094298; rs9957225; rs12961713; rs565576; rs10871751; rs7233095; rs7230539; rs17760597; rs541427; rs11874311; rs12955136; rs9989576; rs473197; rs4149594; rs17064913; rs4941351; rs559636; rs11152063; rs2277718; rs9989592; rs1663041; rs10503021; rs17064342; rs8091196; rs17231892; rs17064483; rs17064879; rs17693634; rs150384; rs8084648; rs531104; rs523986; rs6566929; rs12963674; rs158860; rs12963630; rs11874278; rs9989620; rs1864920; rs12958393; rs503310; rs17064888; rs17064946; rs4149610; rs12964776; rs17064950; rs10515976; rs17064328; rs17756323; rs10439057; rs17064944; rs12326982; rs8094712; rs4940672; rs8090870; rs17064625; rs532894; rs17833707; rs7236464; rs7227056; rs17064654; rs17808190; rs557036; rs12326405; rs4941333; rs9965998; rs9957740; rs11660748; rs17833671; rs12458981; rs8092126; rs7407205; rs8095085; rs12455559; rs17064939; rs12456846; rs8088889; rs17064735; rs477257; rs1787773; rs4941374; rs11665627; rs9954083; rs17064741; rs6566963; rs158864; rs8088115; rs17064935; rs17064952; rs17760402; rs11665546; rs7242397; rs17806115; rs9965313; rs7236010; rs2000855; rs9953645; rs8088474; rs2440193; rs642085; rs4940670; rs17064863; rs12970001; rs12954064; rs580471; rs7244907; rs17755337; rs1977945; rs12955484; rs7236132; rs17064855; rs1893750; rs12954457; rs503073; rs1977946; rs17064941; rs17755321; rs516354; rs17833599; rs17064948; rs11876334; rs508623; rs7235976; rs17693949; rs8092552; rs8086947; rs9807169; rs9950346; rs17064750; rs8097251; rs17064883; rs9807605; rs7239483; rs12957255; rs6566926; rs17693622; rs578084; rs11876767; rs12456045; rs6566930; rs8093023; rs7234852; rs4149603; rs9960929; rs486117; rs8095089; rs7231040; rs8096864; rs7243469; rs9748835; rs8085111; rs8088743; rs12606685; rs17064650; rs190010; rs896750; rs17064757; rs9989619; rs9319927; rs17064780; rs17064891; rs2288773; rs17064701; rs9955628; rs4940674; rs7239274; rs10083983; rs4941335; rs12967469; rs7243326; rs17064667; rs574626; rs12051999; rs8086905; rs10163777; rs9963992; rs9959043; rs17693604; rs12960902; rs9956242; rs11665115; rs12052001; rs9958896; rs7228829; rs7242262; rs4149614; rs12150766; rs11872836; rs8084158; rs4355014; rs9955426; rs9961191; rs502163; rs8099661; rs17064593; rs17808061; rs569277; rs7236193; rs292452; rs4941372; rs529445; rs8083106; rs8097163; rs9952299; rs17235782; rs17064505; rs11665288; rs2319609; rs12455904; rs4621061; rs476420; rs12456994; rs17693701; rs12963185; rs566087; rs480754; rs45448; rs158863; rs17064345; rs12454583; rs1787774; rs17062443; rs4149611; rs7243373; rs7227636; rs10163714; rs12960370; rs12456838; rs8094065; rs17064936; rs4340402; rs4072561; rs7226681; rs559951; rs6566927; rs12958178; rs10460144; rs17064503; rs9319926; rs9948817; rs8092805; rs17064596; rs950939; rs6650727; rs17807652; rs17064621; rs12456835; rs17064904; rs17233743; rs11659751; rs9807168; rs7240364; rs4381674; rs17064679; rs48000; rs12150702; rs7239848; rs11872262; rs9636032; rs7227001; rs17756149; rs17808031; rs4940642; rs17064706; rs7235250; rs8092818; rs6566945; rs2849214; rs7230985; rs17064791; rs11152056; rs646509; rs12968145; rs34792654; rs11152067; rs1943993; rs35265055; rs34029164; rs1044493; rs11433892; rs34842701; rs11353228; rs34594423; rs10660224; rs34040455; rs567226; rs36022323; rs1670326; rs12456990; rs13381917; rs11434919; rs4940668; rs497038; rs10706255; rs35819264; rs35066373; rs12963504; rs1031122; rs10666589; rs12956570; rs33923139; rs11376555; rs35550911; rs34227801; rs35525814; rs35418156; rs34639145; rs9947352; rs35172365; rs499500; rs9807785; rs11377224; rs34546456; rs176754; rs4149615; rs5825267; rs9989621; rs4149602; rs1285352; rs34658652; rs34622462; rs28638370; rs576109; rs8087059; rs188351; rs35030405; rs12604906; rs12959306; rs548320; rs7231889; rs35416657; rs28441489; rs7230229; rs9952515; rs35273931; rs507854; rs11443994; rs35953494; rs1663043; rs34280771; rs11439150; rs1787770; rs7232429; rs292454; rs11269772; rs34928650; rs7234313; rs12326838; rs2920494; rs8093767; rs35734390; rs5825265; rs11350356; rs5825272; rs8083748; rs693864; rs474911; rs34124678; rs561971; rs12970711; rs28462128; rs513435; rs582101; rs11665621; rs12966278; rs7235498; rs11343860; rs12604462; rs492691; rs11452407; rs11363730; rs562722; rs1670334; rs34164994; rs35976964; rs565257; rs191907; rs7240430; rs35812554; rs12968897; rs1670329; rs549531; rs34042427; rs8092006; rs12608173; rs36112838; rs34644275; rs36218819; rs12954778; rs9960340; rs35310744; rs34001228; rs35222707; rs190005; rs34381915; rs11875074; rs693750; rs34067523; rs11428475; rs4149600; rs9949110; rs34208996; rs34406608; rs35603239; rs2053963; rs34525242; rs8095660; rs35766513; rs575011; rs12970622; rs492648; rs13380918; rs5825260; rs34431035; rs1300136; rs33951095; rs1670327; rs11443274; rs11152068; rs11456666; rs503475; rs6566932; rs474322; rs35378668; rs12954787; rs8099132; rs8086810; rs28567712; rs35192183; rs10717406; rs475604; rs536970; rs9957282; rs11399898; rs4149612; rs527013; rs4940388; rs8093734; rs34965383; rs292441; rs10665833; rs34353138; rs35632443; rs176756; rs504286; rs176752; rs36023671; rs560824; rs520387; rs35314135; rs499820; rs506146; rs41537144; rs474924; rs13313677; rs35320308; rs9965372; rs505218; rs520132; rs5825274; rs7504229; rs558195; rs34259379; rs35111781; rs28625940; rs35683540; rs28532065; rs11364816; rs11152057; rs569264; rs28678259; rs12966283; rs191911; rs35003997; rs4941336; rs34559916; rs28568337; rs35246431; rs186035; rs1670336; rs479309; rs11288765; rs12960786; rs35001999; rs4424984; rs7227763; rs10649020; rs12960355; rs7227653; rs511342; rs1815885; rs34145756; rs35431664; rs1299853; rs566322; rs11280693; rs35755247; rs547603; rs9963750; rs12960340; rs11663373; rs12955992; rs35706122; rs11285323; rs10555499; rs13381995; rs503421; rs35132150; rs28393967; rs35025153; rs35044852; rs8086884; rs28644383; rs591608; rs533677; rs28435764; rs35509600; rs7232891; rs8098066; rs34336961; rs9319925; rs12966385; rs17064375; rs5825261; rs4940676; rs501313; rs520574; rs512414; rs5825269; rs34251792; rs17694201; rs11365674; rs35813484; rs544171; rs622598; rs11662229; rs1299367; rs9949775; rs549037; rs35525973; rs35757123; rs9954538; rs183304; rs35369118; rs35718137; rs191914; rs9965187; rs35874222; rs10538442; rs33993931; rs33930298; rs1539933; rs188350; rs33986394; rs550359; rs502437; rs34879628; rs1815886; rs28651872; rs524009; rs7230210; rs36080658; rs186033; rs33973111; rs182376; rs11344086; rs11878005; rs577337; rs172377; rs28683754; rs562021; rs538068; rs36036892; rs11152061; rs7228701; rs1298965; rs560761; rs34581009; rs35459784; rs36232990; rs9952093; rs11318354; rs506894; rs4335844; rs539938; rs533534; rs948945; rs33978271; rs190009; rs538730; rs35546653; rs7233451; rs35888707; rs34675886; rs8088074; rs28497993; rs34588316; rs11439394; rs497045; rs35193154; rs536362; rs36018036; rs35661011; rs28602712; rs608187; rs545086; rs28531887; rs33945462; rs8085301; rs12956423; rs487988; rs34993486; rs12962319; rs7230471; rs571843; rs35884073; rs551232; rs5825258; rs35834464; rs556313; rs35820126; rs35259439; rs34711494; rs12960361; rs34667085; rs560128; rs34369490; rs8093026; rs539500; rs5825263; rs34531441; rs7227871; rs10709413; rs9961344; rs504165; rs9966645; rs1145495; rs12961882; rs35796689; rs478249; rs7235725; rs1670331; rs580617; rs1787768; rs592444; rs10550828; rs292446; rs33941026; rs8093704; rs36074660; rs35095232; rs34159753; rs34296748; rs7233556; rs549472; rs35566593; rs34851743; rs34944629; rs35227822; rs628548; rs34372145; rs11364421; rs13339710; rs11322037; rs36048114; rs35457085; rs34120175; rs4941387; rs34978113; rs3865416; rs1297602; rs4149590; rs35084909; rs12955309; rs34935259; rs11268037; rs34033334; rs479726; rs550387; rs1970680; rs8095185; rs12326435; rs34307554; rs35614158; rs34147448; rs502430; rs7231139; rs474876; rs13381234; rs34517636; rs2167773; rs7233282; rs578722; rs2602161; rs1145493; rs34215861; rs11411331; rs36069538; rs35417180; rs1299534; rs536886; rs538092; rs28604973; rs7241638; rs1014633; rs34261657; rs191909; rs553916; rs487990; rs28680199; rs547297; rs35157719; rs10543922; rs190007; rs2586981; rs507688; rs36023807; rs609673; rs11364817; rs28549255; rs9955454; rs10164048; rs9945608; rs525612; rs12326452; rs9989622; rs34610139; rs35541695; rs34907503; rs504620; rs35971879; rs523321; rs5825275; rs35822067; rs12962018; rs581535; rs8084828; rs2920495; rs33977375; rs34387954; rs576252; rs34375334; rs478292; rs34784281; rs553885; rs5825264; rs667318; rs556828; rs7229050; rs33917490; rs491763; rs12971090; rs500583; rs9954318; rs10583562; rs150377; rs12965336; rs183305; rs555056; rs538105; rs34786093; rs35307691; rs35699329; rs566068; rs619733; rs35422628; rs529884; rs496477; rs33959315; rs9966824; rs498170; rs8092332; rs575337; rs10666590; rs5825257; rs12960363; rs10579186; rs8098960; rs11664507; rs34623575; rs502552; rs35195874; rs28426970; rs12966722; rs654935; rs491642; rs176755; rs2083862; rs12964041; rs526241; rs34601020; rs473740; rs34748671; rs35777699; rs36216804; rs529732; rs580727; rs35464364; rs539406; rs12954208; rs34597926; rs1299535; rs34407841; rs34853900; rs531975; rs494487; rs12961475; rs1670328; rs35807300; rs191910; rs523721; rs33931467; rs476351; rs4133478; rs496964; rs34075636; rs34488547; rs35540189; rs2849215; rs34697992; rs34046823; rs5825266; rs28721559; rs9653063; rs575946; rs3217371; rs1663045; rs35814739; rs8099743; rs9945429; rs11876361; rs35568292; rs517792; rs1663044; rs35634926; rs4940673; rs12970577; rs1670332; rs36056251; rs1670333; rs35881225; rs577353; rs12326249; rs176751; rs34222607; rs11659445; rs35048528; rs8087287; rs11314149; rs7242748; rs972106; rs7234292; rs529727; rs12608188; rs28665715; rs10664303; rs7236941; rs574490; rs9963386; rs34065701; rs34444130; rs35064565; rs12961340; rs35909789; rs507056; rs536747; rs539898; rs28452174; rs8092029; rs520348; rs1663042; rs8084442; rs28542880; rs557294; rs35427047; rs36055525; rs191912; rs505924; rs11444453; rs35045737; rs7230909; rs11659306; rs34308286; rs1670335; rs7229995; rs573785; rs12966582; rs553053; rs11442160; rs35114957; rs577183; rs28591615; rs35289750; rs512163; rs503239; rs562114; rs35532882; rs479865; rs10617839; rs183303; rs513849; rs488121; rs495921; rs9965831; rs36037019; rs4444412; rs10682442; rs34380629; rs11452302; rs483338; rs34103175; rs7239419; rs10641509; rs35567822; rs33913403; rs35371720; rs572794; rs188363; rs10535926; rs693528; rs7231855; rs35792725; rs176753; rs36091358; rs9958807; rs10541382; rs11378477; rs1654078; rs548502; rs11416348; rs34190027; rs35664268; rs623070; rs34220312; rs510542; rs35629078; rs5825268; rs12970589; rs33964439; rs559191; rs34027490; rs2304022; rs11399897; rs28804164; rs35937828; rs34668647; rs292442; rs35370991; rs35483920; rs1300135; rs4149613; rs33942672; rs172376; rs10673353; rs36109290; rs569974; rs491420; rs11394157; rs9963330; rs4940664; rs9807582; rs502134; rs35215280; rs565391; rs34137186; rs4245308; rs35077870; rs493621; rs10600171; rs557558; rs12162212; rs210422; rs3063155; rs12961145; rs7228264; rs471506; rs9953600; rs34947066; rs35625462; rs13381029; rs34787512; rs158859; rs7231470; rs12955022; rs8082726; rs4563113; rs11283530; rs186036; rs12150716; rs7227694; rs28584294; rs533674; rs35976441; rs4542741; rs529085; rs499522; rs499679; rs505202; rs182377; rs35351642; rs9958604; rs12970716; rs580239; rs482446; rs28549042; rs4941346; rs35024815; rs9789135; rs689200; rs34500074; rs11336440; rs34192374; rs550451; rs4149599; rs34979688; rs8084079; rs4941381; rs34257024; rs570737; rs10601865; rs2586980; rs9951941; rs524446; rs505828; rs534031; rs526652; rs494055; rs12104006; rs34671195; rs5825271; rs33911620; rs476984; rs34644761; rs5013567; rs11877770; rs36095321; rs519603; rs608189; rs7232726; rs566112; rs527586; rs35472016; rs34561920; rs34769922; rs35984985; rs12954780; rs35885246; rs577703; rs191908; rs7232756; rs512415; rs11425814; rs667365; rs568029; rs532485; rs34479059; rs1285353; rs549738; rs528329; rs17833779; rs35987145; rs11283426; rs11659354; rs548377; rs12604985; rs11437559; rs34769745; rs11405559; rs36121035; rs532679; rs11877731; rs12967665; rs12955988; rs4941376; rs11275898; rs9960771; rs34643985; rs579391; rs7242530; rs2602162; rs4149606; rs477350; rs17234871; rs34446805; rs578120; rs3865417; rs1789247; rs10600170; rs191913; rs693652; rs10578136; rs182375; rs35757799; rs473085; rs533315; rs34841803; rs7232411; rs576284; rs2440192; rs12964991; rs34217101; rs35334839; rs521877; rs7230023; rs3898787; rs494103; rs35125632; rs36035570; rs190006; rs622129; rs525969; rs186034; rs17807227; rs34607377; rs35888502; rs35874179; rs548990; rs549108; rs9956746; rs28465303; rs7243777; rs12966489; rs10164107; rs557341; rs34786147; rs28647359; rs34160501; rs35242976; rs508093; rs172390; rs36048037; rs1970681; rs2288776; rs5825273; rs191906; rs11296007; rs525453; rs28484910; rs34276141; rs12966466; rs543150; rs34960405; rs9964853; rs537955; rs169751; rs1294079; rs12959491; rs7235890; rs7235848; rs8093336; rs12970284; rs34905417; rs10547797; rs36046684; rs35848920; rs36023848; rs1944804; rs538981; rs34058561; rs2586978; rs35935231; rs9957736; rs536956; rs609727; rs580763; rs9989615; rs35453856; rs5825259; rs525733; rs506252; rs35641671; rs529627; rs34406078; rs562017; rs623490; rs36121232; rs28478239; rs568053; rs33980143; rs580012; rs12961884; rs35798011; rs34279885; rs10538443; rs1670330; rs5825262; rs4149604; rs35999182; rs1145496; rs474396; rs11664888; rs34591604; rs34750525; rs36058093; rs34204397; rs514576; rs573731; rs35844936; rs12955303; rs35636113; rs1787769; rs34466213; rs531534; rs503253; rs1299366; rs35716921; rs534158; rs8096649; rs9954077; rs35138154; rs11152055; rs11398377; rs4496245; rs9953520; rs35545013; rs34088423; rs12454716; rs12955342; rs12957320; rs13381441; rs13381443; rs13381672; rs17064956; rs17756406; rs1893859; rs3760545; rs3897657; rs4383235; rs4485450; rs4488539; rs4499325; rs4583344; rs4586538; rs4940680; rs4940681; rs4940682; rs4940683; rs4940685; rs6566922; rs6566966; rs7227349; rs7228326; rs7243190; rs7243671; rs7243958; rs7244027; rs7245352; rs8086017; rs9958167; rs9962179; rs9965842

# Macromolecular_Interacting_Partner_30_General_References:
11840194; 14556380; 14615060; 9455477; 11046148

# Macromolecular_Interacting_Partner_30_References:
15586017; 15958725; 16150899; 16571785

End of HMDB00037

Beginning of HMDB00038
# Accession_No:
HMDB00038

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-12 16:42:13

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Dihydrobiopterin

# Description:
Dihydrobiopterin is an oxidation product of tetrahydrobiopterin. Tetrahydrobiopterin is a natural occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. Tetrahydrobiopterin is also essential for nitric oxide synthase catalyzed oxidation of L-arginine to L-citrulline and nitric oxide.

# Synonyms:
(S-(R*,S*))-2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone; 7,8-Dihydro-L-biopterin; 7,8-Dihydrobiopterin; Dihydrobiopterin; L-erythro-1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-1,2-Propanediol; L-erythro-7,8-Dihydrobiopterin; L-erythro-Dihydrobiopterin; L-erythro-q-Dihydrobiopterin; Quinonoid dihydrobiopterin

# Chemical_IUPAC_Name:
2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one

# Chemical_Formula:
C9H13N5O3

# Chemical_Structure:
tbl_chemical:::HMDB00038_ZOOM.png:::119283148486928636

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00038_THUMB.png:::119283148283844926

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
imine; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; secondary amine; secondary aliphatic/aromatic amine (alkylarylamine); oxo(het)arene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Folate biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
239.10184

# Molecular_Weight_Avg:
239.23122

# Smiles_String_isomeric:
CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O

# Smiles_String_canonical:
CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O

# KEGG_Compound_ID:
C02953

# BioCyc_ID:
BIOPTERIN

# PubChem_CID:
252

# PubChem_SID:
2171; 5871; 6577875; 6591724

# OMIM_ID:
182125; 261630; 261640

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
5106

# Ref_ID:
8626754; 84153; 15182855; 12032193; 11301319; 932231; 3665086; 9753429; 11443547; 11738280

# ChEBI_ID:
15375

# CAS_Registry_Number:
6779-87-9

# InChI:
InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
129.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
1.63 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-1.65 [Predicted by ALOGPS]; -2.2 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C02953.mol:::1132723802859476765

# SDF_File_[Text]:
tbl_chemical:::HMDB00038.sdf:::119283147848238602

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00038.pdb:::119283148116026132

# PDB_ID:
1DCP

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1DCP.txt:::1132720899546636990

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::7,8-Dihydrobiopterin.gif:::1132732101484228036

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00038_peaks.txt:::115630950391411275

# Predicted_C_NMR_Spectrum:
tbl_chemical:::7,8-Dihydrobiopterin_C.gif:::1132737664487506285

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00038_peaks.txt:::1156310695560477413

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00038L.png:::119015613756853229

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Not Available

# deuterated:
No

# Biofluid_Location:
Blood; CSF

# Concentration_[Normal]:
Blood	0.006 +/- 0.0003	uM	Adult:>18_yrs_old	Both	Normal	12032193
Cerebrospinal_Fluid(CSF)	0.0004-0.014	uM	Adult:>18_yrs_old	Both	Normal	12032193


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Deficiency of Various Neurotransmitters in the Central Nervous System; Hyperphenylalaninemia

# Pathway_Names:
Folate biosynthesis

# Pathway_Images:
Not Available

# KEGG_Images:
map00790

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5673

# Metabolic_Enzyme_1_Name:
Sepiapterin reductase

# Metabolic_Enzyme_1_Synonyms:
SPR

# Metabolic_Enzyme_1_Gene_Name:
SPR

# Metabolic_Enzyme_1_Protein_Sequence:
>Sepiapterin reductase
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
LLSLLEKDEFKSGAHVDFYDK

# Metabolic_Enzyme_1_Number_of_Residues:
261

# Metabolic_Enzyme_1_Molecular_Weight:
28049

# Metabolic_Enzyme_1_Theoretical_pI:
8.19

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  sepiapterin reductase activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  cellular metabolism
Process:  aromatic compound metabolism
Process:  aromatic compound biosynthesis
Process:  pteridine and derivative biosynthesis
Process:  tetrahydrobiopterin biosynthesis
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin

# Metabolic_Enzyme_1_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_1_Reaction:
7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.1.1.153

# Metabolic_Enzyme_1_GenBank_ID_Protein:
338021

# Metabolic_Enzyme_1_SwissProt_ID:
SPRE_HUMAN (P35270)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
SPR

# Metabolic_Enzyme_1_Geneatlas_id:
SPR

# Metabolic_Enzyme_1_hgnc_id:
HGNC:11257

# Metabolic_Enzyme_1_PDB_ID:
1Z6Z

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>786 bp
ATGGAGGGCGGGCTGGGGCGTGCTGTGTGCTTGCTGACCGGGGCCTCCCGCGGCTTCGGC
CGGACGCTGGCCCCGCTCCTGGCCTCGCTGCTGTCGCCCGGCTCCGTGCTTGTCCTTAGC
GCCCGCAACGACGAGGCACTGCGCCAGCTGGAGGCCGAGCTGGGCGCCGAGCGGTCTGGC
CTGCGCGTGGTGCGGGTGCCCGCCGACCTGGGCGCCGAGGCCGGCTTGCAGCAGCTGCTC
GGCGCCCTGCGCGAGCTCCCCCGGCCCAAGGGGCTGCAGCGACTGCTGCTTATCAACAAC
GCGGGCTCTCTTGGGGATGTGTCCAAAGGCTTCGTGGACCTGAGTGACTCCACTCAAGTG
AACAACTACTGGGCACTGAACTTGACCTCCATGCTCTGCCTGACTTCCAGCGTCCTGAAG
GCCTTCCCGGACAGTCCTGGCCTCAACAGAACCGTGGTTAACATCTCGTCCCTCTGTGCC
CTGCAACCTTTCAAAGGCTGGGCGCTGTACTGTGCAGGAAAGGCTGCTCGTGATATGCTG
TTCCAGGTCCTGGCGCTGGAGGAACCTAATGTGAGGGTGCTGAACTATGCCCCAGGTCCT
CTGGACACAGACATGCAGCAGTTGGCCCGGGAGACCTCCGTGGACCCAGACATGCGAAAA
GGGCTGCAGGAGCTGAAGGCAAAGGGGAAGCTGGTGGATTGCAAGGTGTCAGCCCAGAAA
CTGCTGAGCTTACTGGAAAAGGACGAGTTCAAGTCTGGAGCCCACGTGGACTTCTATGAC
AAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M76231

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2p14-p12

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1883349; 8440319; 11825621

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
6070

# Metabolic_Enzyme_2_Name:
Dihydrofolate reductase

# Metabolic_Enzyme_2_Synonyms:
Not Available

# Metabolic_Enzyme_2_Gene_Name:
DHFR

# Metabolic_Enzyme_2_Protein_Sequence:
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

# Metabolic_Enzyme_2_Number_of_Residues:
187

# Metabolic_Enzyme_2_Molecular_Weight:
21453

# Metabolic_Enzyme_2_Theoretical_pI:
7.60

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH group of donors
Function:  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
Function:  dihydrofolate reductase activity
 ||
>>>
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH

# Metabolic_Enzyme_2_Pathway:
map00670  One carbon pool by folate;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_2_Reaction:
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00186:DHFR_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.5.1.3

# Metabolic_Enzyme_2_GenBank_ID_Protein:
182724

# Metabolic_Enzyme_2_SwissProt_ID:
DYR_HUMAN (P00374)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
DHFR

# Metabolic_Enzyme_2_Geneatlas_id:
DHFR

# Metabolic_Enzyme_2_hgnc_id:
HGNC:2861

# Metabolic_Enzyme_2_PDB_ID:
1MVT

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
J00140

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_2_Locus:
5q11.2-q13.2

# Metabolic_Enzyme_2_SNPs:
rs1643630; rs2618372; rs1643650; rs6875184; rs10072026; rs11951910; rs836818; rs1643638; rs1677693; rs1643658; rs10078190; rs836823; rs836821; rs1643659; rs1677691; rs1643635; rs1677694; rs1677634; rs13161245; rs865646; rs1677633; rs844370; rs10052238; rs966762; rs865647; rs1650709; rs2431221; rs10054574; rs34965641; rs865645; rs1643649; rs525054; rs245104; rs11951283; rs1650700; rs1650711; rs245099; rs1650710; rs6453522; rs1677700; rs372069; rs34563643; rs1677696; rs1650714; rs1643664; rs864133; rs1623489; rs1650701; rs35709834; rs1677661; rs11742668; rs836819; rs861373; rs1677692; rs836822; rs860717; rs34781740; rs1677701; rs1650706; rs1650713; rs2560424; rs863216; rs2897261; rs1643657; rs1643661; rs1643634; rs1677666; rs12517451; rs1650723; rs12109877; rs1650720; rs14435; rs11112; rs1053136; rs11550953; rs1129240; rs1129243; rs2431220; rs7387; rs190293; rs34764978; rs35262215; rs1129242; rs34087552; rs10685456; rs1650717; rs13182730; rs1677706; rs10474631; rs34268388; rs35740086; rs6863377; rs10076523; rs2545005; rs1677704; rs1643662; rs1643647; rs1677697; rs7706270; rs10557831; rs2560423; rs3958540; rs863217; rs1677699; rs1643637; rs165957; rs3991269; rs4406117; rs34545755; rs3991268; rs245101; rs11305000; rs1643656; rs1677636; rs1677684; rs11490741; rs1650712; rs34132382; rs1677705; rs2897260; rs1677688; rs3958541; rs34289983; rs863215; rs1677686; rs1650707; rs34468903; rs1650715; rs245103; rs34184316; rs1677702; rs34288321; rs35372305; rs34122957; rs1643660; rs7705115; rs34674884; rs2434329; rs10942929; rs2927911; rs1650716; rs7706404; rs3797876; rs2405873; rs1222967; rs245105; rs1677689; rs34359040; rs11749051; rs1643648; rs2560422; rs1650718; rs1677631; rs10942928; rs34504711; rs11952744; rs3958542; rs35633165; rs1643636; rs836820; rs1650708; rs245100; rs7725721; rs34141487; rs11491447; rs1643663; rs34540063; rs8180493; rs1677687; rs1677695; rs33948142; rs1677685; rs13165178; rs10077031; rs34143020; rs390975; rs12109309; rs10168; rs10474632; rs1105524; rs1222809; rs1232027; rs1382539; rs1382540; rs1382541; rs1382542; rs1478834; rs1478835; rs1643639; rs1643641; rs1643646; rs1643655; rs1650675; rs1650676; rs1650681; rs1650692; rs1650694; rs1650695; rs1650696; rs1650697; rs1677626; rs1677667; rs1677670; rs1677682; rs1677703; rs245102; rs380691; rs3822706; rs384925; rs408626; rs442767; rs453544; rs6878815; rs6897872; rs701383; rs861365

# Metabolic_Enzyme_2_General_References:
6323448; 6687716; 6235374; 3383852; 2248959; 9374868; 1731871

# Metabolic_Enzyme_2_References:
4004257; 759569; 8490294; 8569700

# Metabolic_Enzyme_3_ID:
5816

# Metabolic_Enzyme_3_Name:
Dihydropteridine reductase

# Metabolic_Enzyme_3_Synonyms:
HDHPR; Quinoid dihydropteridine reductase

# Metabolic_Enzyme_3_Gene_Name:
QDPR

# Metabolic_Enzyme_3_Protein_Sequence:
>Dihydropteridine reductase
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF

# Metabolic_Enzyme_3_Number_of_Residues:
244

# Metabolic_Enzyme_3_Molecular_Weight:
25790

# Metabolic_Enzyme_3_Theoretical_pI:
7.45

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases

# Metabolic_Enzyme_3_Pathway:
map00790  Folate biosynthesis

# Metabolic_Enzyme_3_Reaction:
a 5,6,7,8-tetrahydropteridine + NAD(P)+ = a 6,7-dihydropteridine + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00106:adh_short

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.5.1.34

# Metabolic_Enzyme_3_GenBank_ID_Protein:
30819

# Metabolic_Enzyme_3_SwissProt_ID:
DHPR_HUMAN (P09417)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
QDPR

# Metabolic_Enzyme_3_Geneatlas_id:
QDPR

# Metabolic_Enzyme_3_hgnc_id:
HGNC:9752

# Metabolic_Enzyme_3_PDB_ID:
1HDR

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>735 bp
ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC
GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT
GATGTGGTGGAGAATGAAGAGGCCAGCGCTACGATCATTGTTAAAATGACAGACTCGTTC
ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG
GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC
TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT
CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC
CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC
TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG
CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC
TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC
CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC
CCAGCATATTTTTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X04882

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_3_Locus:
4p15.31

# Metabolic_Enzyme_3_SNPs:
rs3733570; rs12645938; rs3733569; rs2597775; rs1031327; rs1031326; rs1049581; rs1049600; rs699459; rs1049601; rs10604; rs699460; rs1049582; rs2597778; rs10008024; rs10006709; rs1411985; rs2315248; rs12644621; rs10939729; rs2518609; rs3822231; rs3733575; rs12512471; rs10004095; rs4698601; rs6819744; rs6827193; rs7660043; rs2518613; rs2518610; rs2597770; rs11722315; rs744729; rs2518616; rs731437; rs17458406; rs2253130; rs3796809; rs10013112; rs3094278; rs2252995; rs7696913; rs12647753; rs2518618; rs2597768; rs744731; rs2518615; rs7662925; rs9998021; rs10516314; rs10000532; rs10011038; rs2244804; rs12644449; rs12498807; rs9995626; rs3775922; rs10084995; rs11946133; rs3733572; rs2597777; rs12511229; rs13121927; rs3733573; rs28418409; rs10939724; rs10939725; rs7670743; rs3775921; rs3733574; rs3822234; rs2597767; rs744730; rs7676618; rs10030250; rs10020171; rs2518624; rs2518625; rs2597766; rs6449303; rs6811303; rs2244788; rs2597765; rs2305316; rs2597764; rs2597781; rs2518623; rs1031325; rs2315246; rs2315247; rs12512495; rs11556809; rs2518608; rs11556811; rs41268391; rs1803486; rs35601449; rs9995723; rs28407193; rs2305315; rs2518614; rs6841929; rs34374888; rs35810383; rs2597769; rs2518611; rs2597771; rs10027962; rs10031275; rs3733571; rs28678909; rs2597774; rs28587968; rs28465580; rs10008333; rs41268393; rs28547068; rs7436922; rs28394602; rs36202813; rs28548890; rs4083729; rs10028346; rs34235865; rs28391487; rs10050325; rs5856425; rs35863325; rs28375535; rs34319569; rs34528211; rs11736337; rs3822233; rs28435289; rs2597773; rs2518612; rs35068359; rs12498326; rs34914923; rs34012502; rs13137081; rs35469730; rs34100425; rs35826618; rs28449900; rs10632253; rs12647416; rs28580482; rs34858847; rs35314811; rs2597776; rs10598892; rs3217604; rs2597779; rs28621908; rs5856426; rs11351628; rs10022501; rs28425622; rs7685575; rs2518622; rs2597772; rs35054011; rs34311884; rs7660847; rs36094070; rs35198436; rs3066734; rs2597780; rs11935131; rs6823650; rs7672603; rs7694662; rs2518606; rs11556808; rs2597782; rs2518607; rs10026004; rs11733530; rs12499694; rs13128422; rs13128427; rs13128864; rs13131273; rs13138275; rs1473352; rs1551091; rs1551092; rs16895134; rs16895143; rs1868733; rs1868734; rs1868735; rs2122571; rs2247952; rs2518603; rs2518604; rs2518605; rs2518626; rs2597752; rs2597753; rs2597754; rs2597755; rs2597756; rs2597757; rs2597758; rs2597783; rs2597784; rs2597786; rs2697688; rs2697689; rs4698189; rs4698599; rs4698603; rs6817052; rs6835304; rs7661303

# Metabolic_Enzyme_3_General_References:
3031582; 3033643; 9744478; 8262916; 7627180; 8326489; 2116088; 10408783; 11153907

# Metabolic_Enzyme_3_References:
8490294

End of HMDB00038

Beginning of HMDB00039
# Accession_No:
HMDB00039

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:42:35

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Butyric acid

# Description:
Butyric acid, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC).  Butyrate has diverse and apparently paradoxical effects on cellular proliferation, apoptosis and differentiation that may be either pro-neoplastic or anti-neoplastic, depending upon factors such as the level of exposure, availability of other metabolic substrate and the intracellular milieu.  In humans, the relationship between luminal butyrate exposure and CRC has been examined only indirectly in case-control studies, by measuring fecal butyrate concentrations, although this may not accurately reflect effective butyrate exposure during carcinogenesis.  Perhaps not surprisingly, results of these investigations have been mutually contradictory.  The direct effect of butyrate on tumorigenesis has been assessed in a no. of in vivo animal models, which have also yielded conflicting results.  In part, this may be explained by methodology: differences in the amount and route of butyrate administration, which are likely to significantly influence delivery of butyrate to the distal colon.  (PMID 16460475) Butyric acid is a carboxylic acid found in rancid butter, parmesan cheese, and vomit, and has an unpleasant odor and acrid taste, with a sweetish aftertaste (similar to ether). Butyric acid is a fatty acid occurring in the form of esters in animal fats and plant oils. Interestingly, low-molecular-weight esters of butyric acid, such as methyl butyrate, have mostly pleasant aromas or tastes. As a consequence, they find use as food and perfume additives. Butyrate is produced as end-product of a fermentation process solely performed by obligate anaerobic bacteria.

# Synonyms:
1-Butyrate; 1-Butyric acid; 1-Propanecarboxylate; 1-Propanecarboxylic acid; 1-butanoate; 1-butanoic acid; Butanate; Butanic acid; Butanoate; Butanoic acid; Buttersaeure; Butyrate; Ethylacetate; Ethylacetic acid; Honey robber; Kyselina maselna; Propanecarboxylate; Propanecarboxylic acid; Propylformate; Propylformic acid; butyric acid; n-Butanoate; n-Butanoic acid; n-Butyrate; n-Butyric acid

# Chemical_IUPAC_Name:
Butanoic acid

# Chemical_Formula:
C4H8O2

# Chemical_Structure:
tbl_chemical:::HMDB00039_ZOOM.png:::119283149338870780

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00039_THUMB.png:::11928314916101480

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Energy source; DNA component

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
88.05243

# Molecular_Weight_Avg:
88.10513

# Smiles_String_isomeric:
CCCC(O)=O

# Smiles_String_canonical:
CCCC(O)=O

# KEGG_Compound_ID:
C00246

# BioCyc_ID:
Not Available

# PubChem_CID:
264

# PubChem_SID:
3545; 7886373; 11120324; 587668; 11447352; 7849658; 8145230; 639195; 584341; 829106; 11528267; 11405819; 10318186; 2182; 539318; 151005; 11120812; 10503556; 8150539; 841341; 10348531; 4802290; 7986037; 10318189; 833290; 563607; 7853006; 825651; 74110; 11121300; 8137924; 3132316

# OMIM_ID:
Not Available

# Metagene_ID:
GABA TRANSAMINASE DEFICIENCY: 32; HYPER BETA-ALANINEMIA: 204; 4-HYDROXYBUTYRIC ACIDURIA: 7; ARTEFACTS-PHARMACEUTICAL PRODUCTS, INTERFERENCE IN AMINOACID AND ORGANIC ACID ANALYSIS [DD]: 347; 3-HYDROXYISOBUTYRIC ACIDURIA: 307; 2-HYDROXYGLUTARIC ACIDURIA (D): 281; MAPLE SYRUP URINE DISEASE. BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE DEFICIENCY (MSUD): 1; PYRIDOXINE DEPENDENCY WITH SEIZURES: 360; 2-METHYL-3-HYDROXYBUTYRYL-CoA DEHYDROGENASE DEFICIENCY: 457; PERSISTANT HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY, PHHI: 255; FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY: 128; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; GLUTARIC ACIDURIA II: 9; KETOSIS, UNSPECIFIC [DD]: 279; METHYLMALONIC ACIDURIA (MMA): 15; GLUTARIC ACIDURIA I: 8; ASPHYXIA [DD]: 408; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; SHORT-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (SCHAD): 393; BIOTINIDASE DEFICIENCY: 73; ISOVALERIC ACIDEMIA: 10; BETA-KETOTHIOLASE DEFICIENCY: 5; METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY: 485

# BiGG_ID:
34376

# Wikipedia_ID:
Butyric acid

# METLIN_ID:
107

# Ref_ID:
12618885; 6826253; 12097436; 12663299; 12067385; 6288683; 15193738; 12004211; 15385498; 14745451; 6268944; 15703366; 15800932; 11953371; 9244653; 9361838; 6257378; 9071566

# ChEBI_ID:
30772

# CAS_Registry_Number:
107-92-6

# InChI:
InChI=1/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)

# Synthesis_Reference:
 Journal of the Chemical Society  (1934),     26-9.

# Melting_Point:
-5.7 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
60.0 mg/mL [HEMPHILL,L & SWANSON,WS (1964)]

# H2O_Solubility_Predicted:
239.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
0.79 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
0.78 [Predicted by ALOGPS]; 0.7 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Butyric acid Na salt.htm:::1132562192618105579

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Butyric_acid.mol:::1132723802953871928

# SDF_File_[Text]:
tbl_chemical:::HMDB00039.sdf:::119283148874851826

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00039.pdb:::119283149028654015

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_PRESAT_expanded_2.gif:::11416824637978376

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_presat.zip:::1175124407386523404

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041004_P00_05_HW_1DP_Assigned.png:::114659877040280025

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::107-92-6-presat_JM.GIF:::1132883804765529763

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041004_P00_05_HW_1DP_PRESAT_1.zip:::11446078492841069

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17.jpg:::11443659266855339

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17.zip:::114436592672920288

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041004_P00_05_HW_1DC_17_Assigned.jpg:::114488409548798836

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59.jpg:::11448841775699721

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59.zip:::114488417760476664

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041004_P00_05_HW_2DHSQC_59_Assigned.jpg:::114488417779319269

# Predicted_H_NMR_Spectrum:
tbl_chemical:::butyric acid.gif:::1132732101515281785

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00039_peaks.txt:::1156309504938619381

# Predicted_C_NMR_Spectrum:
tbl_chemical:::butyric acid_C.gif:::1132737664537530469

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00039_peaks.txt:::1156310696578392874

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00039L.png:::117555262540864016; Medium Energy:tbl_ms:::HMDB00039M.png:::117555267886184459; High Energy:tbl_ms:::HMDB00039H.png:::117555271486213415

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Fibroblasts; Intestine; Kidney; Large Intestine; Muscle; Neurons; Prostate

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Saliva; Urine

# Concentration_[Normal]:
Urine	0.086 +/- 0.0085	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9071566
Blood	1.0 (0.3- 1.5)	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	1.4 (0-2.8)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Saliva	1470 (0.00-2940)	umol/L	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	0.18 +/- 0.044	umol/mmol_creatinine	Adult:>18_yrs_old	Both	AIDS	9071566


# Associated_Disorders:
AIDS; Crohn's Disease; Hypoglycemia; Ulcerative Colitis

# Pathway_Names:
Butanoate metabolism

# Pathway_Images:
Not Available

# KEGG_Images:
map00650

# Pathway_Graphs:
Not Available

# Pathway_SBMLs:
Not Available

# Metabolic_Enzyme_1_ID:
5823

# Metabolic_Enzyme_1_Name:
Middle-chain acyl-CoA synthetase1

# Metabolic_Enzyme_1_Synonyms:
Medium-chain acyl-CoA synthetase

# Metabolic_Enzyme_1_Gene_Name:
BUCS1

# Metabolic_Enzyme_1_Protein_Sequence:
>Middlechain acylCoA synthetase1
MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWA
QKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPR
VPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCP
SLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSH
GLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTK
VIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTG
LLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRI
KPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIG
PAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSV
TAPYKYPRNVEFVSELPKTITGKIERKELRKKETGQM

# Metabolic_Enzyme_1_Number_of_Residues:
577

# Metabolic_Enzyme_1_Molecular_Weight:
65260

# Metabolic_Enzyme_1_Theoretical_pI:
8.28

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Not Available

# Metabolic_Enzyme_1_Pathway:
Not Available

# Metabolic_Enzyme_1_Reaction:
Not Available

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.2.1.2

# Metabolic_Enzyme_1_GenBank_ID_Protein:
15706421

# Metabolic_Enzyme_1_SwissProt_ID:
Q96A20_HUMAN (Q96A20)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BUCS1

# Metabolic_Enzyme_1_Geneatlas_id:
BUCS1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:18049

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1734 bp
ATGCAGTGGCTAATGAGGTTCCGGACCCTCTGGGGCATCCACAAATCCTTCCACAACATC
CACCCTGCCCCTTCACAGCTGCGCTGCCGGTCTTTATCAGAATTTGGAGCCCCAAGATGG
AATGACTATGAAGTACCGGAGGAATTTAACTTTGCAAGTTATGTACTGGACTACTGGGCT
CAAAAGGAGAAGGAGGGCAAGAGAGGTCCAAATCCAGCTTTTTGGTGGGTGAATGGCCAA
GGGGATGAAGTAAAGTGGAGCTTCAGAGAGATGGGAGACCTAACCCGCCGTGTAGCCAAC
GTCTTCACACAGACCTGTGGCCTACAACAGGGAGACCATCTGGCCTTGATGCTGCCTCGA
GTTCCTGAGTGGTGGCTGGTGGCTGTGGGCTGCATGCGAACAGGGATCATCTTCATTCCT
GCGACCATCCTGTTGAAGGCCAAAGACATTCTCTATCGACTACAGTTGTCTAAAGCCAAG
GGCATTGTGACCATAGATGCCCTTGCCTCAGAGGTGGACTCCATAGCTTCTCAGTGCCCC
TCTCTGAAAACCAAGCTCCTGGTGTCTGATCACAGCCGTGAAGGGTGGCTGGACTTCCGA
TCGCTGGTTAAATCAGCATCCCCAGAACACACCTGTGTTAAGTCAAAGACCTTGGACCCA
ATGGTCATCTTCTTCACCAGTGGGACCACAGGCTTCCCCAAGATGGCAAAACACTCCCAT
GGGTTGGCCTTACAACCCTCCTTCCCAGGAAGTAGGAAATTACGGAGCCTGAAGACATCT
GATGTCTCCTGGTGCCTGTCGGACTCAGGATGGATTGTGGCTACCATTTGGACCCTGGTA
GAACCATGGACAGCGGGTTGTACAGTCTTTATCCACCATCTGCCACAGTTTGACACCAAG
GTCATCATACAGACATTGTTGAAATACCCCATTAACCACTTTTGGGGGGTATCATCTATA
TATCGAATGATTCTGCAGCAGGATTTCACCAGCATCAGGTTCCCTGCCCTGGAGCACTGC
TATACTGGCGGGGAGGTCGTGTTGCCCAAGGATCAGGAGGAGTGGAAAAGACGGACGGGC
CTTCTGCTCTACGAGAACTATGGGCAGTCGGAAACGGGACTAATTTGTGCCACCTACTGG
GGAATGAAGATCAAGCCGGGTTTCATGGGGAAGGCCACTCCACCCTATGACGTCCAGGTC
ATTGATGACAAGGGCAGCATCCTGCCACCTAACACAGAAGGAAACATTGGCATCAGAATC
AAACCTGTCAGGCCTGTGAGCCTCTTCATGTGCTATGAGGGTGACCCAGAGAAGACAGCT
AAAGTGGAATGTGGGGACTTCTACAACACTGGGGACAGAGGAAAGATGGATGAAGAGGGC
TACATTTGTTTCCTGGGGAGGAGTGATGACATCATTAATGCCTCTGGGTATCGCATCGGG
CCTGCAGAGGTTGAAAGCGCTTTGGTGGAGCACCCAGCGGTGGCGGAGTCAGCCGTGGTG
GGCAGCCCAGACCCGATTCGAGGGGAGGTGGTGAAGGCCTTTATTGTCCTGACCCCACAG
TTCCTGTCCCATGACAAGGATCAGCTGACCAAGGAACTGCAGCAGCATGTCAAGTCAGTG
ACAGCCCCATACAAGTACCCAAGGAACGTGGAGTTTGTCTCAGAGCTGCCAAAAACCATC
ACTGGCAAGATTGAACGGAAGGAACTTCGGAAAAAGGAGACTGGTCAGATGTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AB062503

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_1_Locus:
16p12.2

# Metabolic_Enzyme_1_SNPs:
rs8056709; rs16970453; rs151328; rs3743690; rs2301672; rs1692729; rs3087812; rs6497510; rs1390818; rs7195380; rs3883991; rs1112308; rs6497512; rs7191240; rs3907531; rs3907532; rs1390819; rs7195927; rs2521576; rs9927979; rs10852245; rs4783410; rs9927872; rs433598; rs1551567; rs163236; rs151327; rs7498905; rs163235; rs163274; rs397132; rs163275; rs399499; rs163238; rs168102; rs163265; rs163269; rs163276; rs231921; rs163259; rs163273; rs396508; rs163277; rs1845919; rs395501; rs17688192; rs992381; rs231930; rs163278; rs180286; rs234280; rs3913150; rs1673057; rs16970493; rs163271; rs163234; rs4092390; rs163242; rs11643793; rs151309; rs11864505; rs16970500; rs9930741; rs234279; rs9930784; rs151310; rs231928; rs12928136; rs9930187; rs163237; rs7202947; rs163268; rs7187142; rs7198885; rs234288; rs163257; rs16970542; rs3743689; rs163239; rs9926662; rs1845918; rs13339208; rs163262; rs11866223; rs1673062; rs13334726; rs163256; rs10400933; rs9929412; rs151222; rs9937963; rs170897; rs151329; rs7203759; rs234276; rs11641336; rs163255; rs16970539; rs16970475; rs11643819; rs1673067; rs231927; rs2645264; rs163260; rs163272; rs231929; rs234993; rs16970506; rs9937871; rs163240; rs1473539; rs180149; rs1673071; rs163245; rs1673069; rs9922083; rs1673060; rs2524397; rs231923; rs163263; rs163241; rs12929282; rs234286; rs7189209; rs9933531; rs8046100; rs163267; rs9937753; rs163244; rs1673061; rs163246; rs234278; rs11860368; rs2935289; rs876106; rs1673070; rs2905825; rs1390811; rs1551568; rs9932231; rs9935309; rs937380; rs13337936; rs978161; rs7189675; rs1948567; rs870940; rs163251; rs870941; rs978160; rs13333421; rs16970511; rs2645266; rs4105168; rs4028210; rs34297096; rs35070485; rs5816128; rs34283792; rs7205700; rs1353560; rs11866514; rs11482245; rs3905816; rs2791579; rs9708612; rs4028209; rs6497509; rs34163951; rs36091171; rs35100724; rs5816129; rs2791578; rs2645267; rs2524395; rs2636952; rs34133125; rs338306; rs1692728; rs2645265; rs10696412; rs163270; rs163266; rs12928278; rs231926; rs34844087; rs193138; rs407385; rs34880359; rs12918948; rs553823; rs34392148; rs34719963; rs12928554; rs180031; rs12923779; rs36118125; rs551997; rs231931; rs2935290; rs34261689; rs28617427; rs35367768; rs13330264; rs36139670; rs34141030; rs163261; rs28407561; rs407115; rs13334424; rs34051844; rs34001827; rs234273; rs28504227; rs34600525; rs12928747; rs193137; rs7501250; rs12050994; rs3073712; rs35700474; rs420735; rs28502691; rs35210350; rs193136; rs231920; rs34430083; rs2524396; rs12443593; rs9927399; rs35868298; rs34164754; rs34630589; rs186824; rs10573087; rs9939024; rs151330; rs12444145; rs34734974; rs231932; rs28641656; rs35787577; rs1673068; rs34036026; rs234272; rs11866405; rs35427586; rs35998307; rs231924; rs163258; rs4102379; rs4783458; rs5816130; rs1692730; rs234275; rs28426994; rs231919; rs35083253; rs34512335; rs34183294; rs28412173; rs34043568; rs35383605; rs2645263; rs35604326; rs5816131; rs1258920; rs163264; rs34586953; rs12921149; rs34327518; rs34192117; rs163243; rs180033; rs34123913; rs12922706; rs407374; rs12923773; rs34679769; rs28835921; rs28704796; rs12929314; rs28682534; rs33995958; rs4102380; rs9923104; rs28419751; rs552941; rs4783459; rs10696411; rs28635930; rs12922692; rs34041438; rs34894022; rs36182498; rs12924069; rs13333306; rs5816133; rs170924; rs35122439; rs2880113; rs35868801; rs151307; rs231922; rs407376; rs12923216; rs36099382; rs12922571; rs231925; rs11649650; rs7500012; rs2355929; rs28648969; rs28460160; rs35087522; rs168103; rs231933; rs151308; rs1460; rs10613980; rs10564254; rs10613979; rs1464; rs35507753; rs28739281; rs10431893; rs11643502; rs11859792; rs1390812; rs1390816; rs1496759; rs1496763; rs163253; rs16970546; rs3073716; rs34661230; rs7202085; rs7498582; rs8047205; rs8048603; rs9925895; rs9937289; rs9938235

# Metabolic_Enzyme_1_General_References:
11470804

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
7792

# Metabolic_Enzyme_2_Name:
Mitogen-activated protein kinase 14

# Metabolic_Enzyme_2_Synonyms:
Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A

# Metabolic_Enzyme_2_Gene_Name:
MAPK14

# Metabolic_Enzyme_2_Protein_Sequence:
>Mitogenactivated protein kinase 14
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES


# Metabolic_Enzyme_2_Number_of_Residues:
360

# Metabolic_Enzyme_2_Molecular_Weight:
41294

# Metabolic_Enzyme_2_Theoretical_pI:
5.58

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis

# Metabolic_Enzyme_2_Pathway:
Not Available

# Metabolic_Enzyme_2_Reaction:
Not Available

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00069:Pkinase

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.7.11.24

# Metabolic_Enzyme_2_GenBank_ID_Protein:
603917

# Metabolic_Enzyme_2_SwissProt_ID:
MK14_HUMAN (Q16539)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
MAPK14

# Metabolic_Enzyme_2_Geneatlas_id:
MAPK14

# Metabolic_Enzyme_2_hgnc_id:
HGNC:6876

# Metabolic_Enzyme_2_PDB_ID:
1W84

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_2_Gene_Sequence:
>1083 bp
ATGTCTCAGGAGAGGCCCACGTTCTACCGGCAGGAGCTGAACAAGACAATCTGGGAGGTG
CCCGAGCGTTACCAGAACCTGTCTCCAGTGGGCTCTGGCGCCTATGGCTCTGTGTGTGCT
GCTTTTGACACAAAAACGGGGTTACGTGTGGCAGTGAAGAAGCTCTCCAGACCATTTCAG
TCCATCATTCATGCGAAAAGAACCTACAGAGAACTGCGGTTACTTAAACATATGAAACAT
GAAAATGTGATTGGTCTGTTGGACGTTTTTACACCTGCAAGGTCTCTGGAGGAATTCAAT
GATGTGTATCTGGTGACCCATCTCATGGGGGCAGATCTGAACAACATTGTGAAATGTCAG
AAGCTTACAGATGACCATGTTCAGTTCCTTATCTACCAAATTCTCCGAGGTCTAAAGTAT
ATACATTCAGCTGACATAATTCACAGGGACCTAAAACCTAGTAATCTAGCTGTGAATGAA
GACTGTGAGCTGAAGATTCTGGATTTTGGACTGGCTCGGCACACAGATGATGAAATGACA
GGCTACGTGGCCACTAGGTGGTACAGGGCTCCTGAGATCATGCTGAACTGGATGCATTAC
AACCAGACAGTTGATATTTGGTCAGTGGGATGCATAATGGCCGAGCTGTTGACTGGAAGA
ACATTGTTTCCTGGTACAGACCATATTAACCAGCTTCAGCAGATTATGCGTCTGACAGGA
ACACCCCCCGCTTATCTCATTAACAGGATGCCAAGCCATGAGGCAAGAAACTATATTCAG
TCTTTGACTCAGATGCCGAAGATGAACTTTGCGAATGTATTTATTGGTGCCAATCCCCTG
GCTGTCGACTTGCTGGAGAAGATGCTTGTATTGGACTCAGATAAGAGAATTACAGCGGCC
CAAGCCCTTGCACATGCCTACTTTGCTCAGTACCACGATCCTGATGATGAACCAGTGGCC
GATCCTTATGATCAGTCCTTTGAAAGCAGGGACCTCCTTATAGATGAGTGGAAAAGCCTG
ACCTATGATGAAGTCATCAGCTTTGTGCCACCACCCCTTGACCAAGAAGAGATGGAGTCC
TGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L35263

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_2_Locus:
6p21.3-p21.2

# Metabolic_Enzyme_2_SNPs:
Not Available

# Metabolic_Enzyme_2_General_References:
7997261; 7696354; 7479834; 10727080; 11866441; 14574404; 12665801; 7923354; 7493921; 10943842; 10838079; 8910361; 9095200; 9753691

# Metabolic_Enzyme_2_References:
12618885; 14745139; 16356138

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16320810; 16614387

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
14512034; 14720504; 14978972; 15063780

# Macromolecular_Interacting_Partner_3_ID:
7552

# Macromolecular_Interacting_Partner_3_Name:
Interferon gamma precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
IFN-gamma; Immune interferon

# Macromolecular_Interacting_Partner_3_Gene_Name:
IFNG

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Interferon gamma precursor
MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWK
EESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTN
YSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
166

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
19349

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
10.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interferon-gamma receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00714:IFN-gamma

# Macromolecular_Interacting_Partner_3_Signals:
1-23

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
32692

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
IFNG_HUMAN (P01579)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
IFNG

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
IFNG

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:5438

# Macromolecular_Interacting_Partner_3_PDB_ID:
1HIG

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>501 bp
ATGAAATATACAAGTTATATCTTGGCTTTTCAGCTCTGCATCGTTTTGGGTTCTCTTGGC
TGTTACTGCCAGGACCCATATGTAAAAGAAGCAGAAAACCTTAAGAAATATTTTAATGCA
GGTCATTCAGATGTAGCGGATAATGGAACTCTTTTCTTAGGCATTTTGAAGAATTGGAAA
GAGGAGAGTGACAGAAAAATAATGCAGAGCCAAATTGTCTCCTTTTACTTCAAACTTTTT
AAAAACTTTAAAGATGACCAGAGCATCCAAAAGAGTGTGGAGACCATCAAGGAAGACATG
AATGTCAAGTTTTTCAATAGCAACAAAAAGAAACGAGATGACTTCGAAAAGCTGACTAAT
TATTCGGTAACTGACTTGAATGTCCAACGCAAAGCAATACATGAACTCATCCAAGTGATG
GCTGAACTGTCGCCAGCAGCTAAAACAGGGAAGCGAAAAAGGAGTCAGATGCTGTTTCAA
GGTCGAAGAGCATCCCAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X13274

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_3_Locus:
12q14

# Macromolecular_Interacting_Partner_3_SNPs:
rs2069723; rs2069734; rs2069722; rs2234687; rs1042274; rs2069721; rs2069718; rs1861493; rs2069719; rs2069714; rs2069716; rs2069720; rs1861494; rs2069713; rs2069717; rs9282708; rs2234685; rs3087272; rs2069715; rs2069733; rs2430561; rs2193049; rs2069728; rs2069705; rs2069724; rs2069731; rs2193050; rs2069725; rs2069709; rs3181034; rs2069727; rs2069736; rs2069707; rs7956940; rs7956720; rs2069706; rs2069732; rs9282709; rs2069729; rs2069726; rs2069730; rs2069710; rs7957366; rs35040375; rs35314021; rs34079299; rs2069712; rs10611634; rs2234686; rs34399538; rs2069711; rs28910281; rs10599707; rs35008976; rs35994963; rs2069737; rs35751061; rs7956688; rs2069735; rs35815094; rs3814242; rs4394909; rs2069708; rs10878762; rs10878763; rs11177072; rs11177073; rs11177074; rs11831576; rs12306852; rs12366912; rs12369470; rs2098395; rs2111059; rs2870953; rs3181032; rs3181033; rs3181035; rs6421227; rs6581791; rs6581794; rs6581795; rs7138107; rs7139169; rs7298719; rs7302488; rs7350604; rs7968411; rs7969745

# Macromolecular_Interacting_Partner_3_General_References:
6180322; 6173769; 2860101; 6329718; 6176945; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 1525157

# Macromolecular_Interacting_Partner_3_References:
12875900; 14517348; 15025822; 15123634

# Macromolecular_Interacting_Partner_4_ID:
7569

# Macromolecular_Interacting_Partner_4_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_4_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_4_Signals:
1-29

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_4_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_4_Locus:
7p21

# Macromolecular_Interacting_Partner_4_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_4_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_4_References:
12637250; 12819385; 12963019; 15284182

# Macromolecular_Interacting_Partner_5_ID:
7571

# Macromolecular_Interacting_Partner_5_Name:
Intercellular adhesion molecule 1 precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
ICAM-1; Major group rhinovirus receptor; CD54 antigen

# Macromolecular_Interacting_Partner_5_Gene_Name:
ICAM1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Intercellular adhesion molecule 1 precursor
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
57826

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.06

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
ICAM proteins are ligands for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2)

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03921:ICAM_N

# Macromolecular_Interacting_Partner_5_Signals:
1-27

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
481-503

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
758074

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
ICAM1_HUMAN (P05362)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ICAM1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ICAM1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:5344

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1599 bp
ATGGCTCCCAGCAGCCCCCGGCCCGCGCTGCCCGCACTCCTGGTCCTGCTCGGGGCTCTG
TTCCCAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGG
GGAGGCTCCGTGCTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATA
GAGACCCCGTTGCCTAAAAAGGAGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAA
CTGAGCAATGTGCAAGAAGATAGCCAACCAATGTGCTATTCAAACTGCCCTGATGGGCAG
TCAACAGCTAAAACCTTCCTCACCGTGTACTGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGG
GCACCCCGGGCCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAG
CCAGCTGTGGGGGAGCCCGCTGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCAT
GGAGCCAATTTCTCGTGCCGCACTGAACTGGACCTGCGGCCCCAAGGGCTGGAGCTGTTT
GAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGTCCTGCCAGCGACTCCCCCACAA
CTTGTCAGCCCCCGGGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGAC
GGGCTGTTCCCAGTCTCGGAGGCCCAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAAC
CCCACAGTCACCTATGGCAACGACTCCTTCTCGGCCAAGGCCTCAGTCAGTGTGACCGCA
GAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGGGAACCAGAGCCAGGAG
ACACTGCAGACAGTGACCATCTACAGCTTTCCGGCGCCCAACGTGATTCTGACGAAGCCA
GAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAGCCAAGGTG
ACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCC
ACCCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAG
CTTATACACAAGAACCAGACCCGGGAGCTTCGTGTCCTGTATGGCCCCCGACTGGACGAG
AGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATTCCCAGCAGACTCCAATGTGCCAG
GCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCACTTTCCCACTGCCC
ATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCCAGG
AGCACTCAAGGGGAGGTCACCCGCGAGGTGACCGTGAATGTGCTCTCCCCCCGGTATGAG
ATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACG
TACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGG
ACCCCCATGAAACCGAACACACAAGCCACGCCTCCCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
X06990

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_5_Locus:
19p13.3-p13.2

# Macromolecular_Interacting_Partner_5_SNPs:
rs5491; rs1801714; rs5497; rs1799969; rs5494; rs5493; rs5030381; rs13306429; rs35956512; rs5490; rs13306427; rs36086415; rs281433; rs5030377; rs281432; rs281431; rs5030348; rs281430; rs5030351; rs5030362; rs5030352; rs5030340; rs5030370; rs3093035; rs5030391; rs5030365; rs5030347; rs5496; rs281434; rs281428; rs5030354; rs5030364; rs12462944; rs5030395; rs281429; rs5030368; rs5030393; rs11667983; rs5030380; rs5030343; rs5030398; rs5030376; rs5030353; rs5030366; rs5030367; rs11879117; rs5030341; rs5030344; rs5030356; rs5030397; rs5030346; rs12459133; rs3093033; rs5030390; rs2358581; rs5030379; rs7258215; rs5030339; rs5030388; rs5030386; rs35501657; rs422429; rs13306430; rs5495; rs34369517; rs5492; rs2071441; rs372336; rs1800019; rs41520346; rs41276880; rs5030363; rs35769997; rs35660845; rs5030355; rs5030349; rs5030345; rs5030392; rs5030374; rs11575070; rs33958632; rs34542691; rs5030394; rs41360047; rs34215251; rs35590890; rs34434348; rs5030361; rs5030357; rs5030378; rs13306428; rs3073809; rs5030371; rs11575071; rs5030359; rs5030369; rs35871840; rs5030360; rs5030358; rs5827095; rs28432861; rs10420063; rs5030342; rs5030350; rs5030396; rs5030372; rs5030375; rs5030399; rs34496081; rs11575072; rs5030387; rs35643518; rs36213467; rs34546385; rs34876098; rs36213469; rs41468345; rs10402760; rs1056536; rs1056538; rs1057981; rs11575074; rs11669397; rs12972990; rs17852402; rs2071440; rs2075741; rs2075742; rs2228615; rs2569693; rs2569694; rs2569695; rs2569697; rs2569698; rs2569700; rs2569701; rs2569702; rs2569703; rs2569704; rs2569706; rs2569708; rs2735439; rs2735440; rs2735442; rs281437; rs281438; rs281439; rs281440; rs2916058; rs2916060; rs3093030; rs3093032; rs34918248; rs35318566; rs36045754; rs3810159; rs5030384; rs5030385; rs5030400; rs5499; rs5501; rs710845; rs735747; rs885743; rs901886

# Macromolecular_Interacting_Partner_5_General_References:
3340213; 3349522; 2544880; 1680919; 1983003; 2538243; 9539702; 9539703; 10562537; 7525451; 8557254; 9259284; 10391210

# Macromolecular_Interacting_Partner_5_References:
12914760; 15068815; 16496611

# Macromolecular_Interacting_Partner_6_ID:
6105

# Macromolecular_Interacting_Partner_6_Name:
Glutathione S-transferase A2

# Macromolecular_Interacting_Partner_6_Synonyms:
GTH2; HA subunit 2; GST- gamma; GSTA2-2; GST class-alpha member 2

# Macromolecular_Interacting_Partner_6_Gene_Name:
GSTA2

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Glutathione Stransferase A2
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
222

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
25664

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
9.07

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  glutathione transferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

# Macromolecular_Interacting_Partner_6_Pathway:
map00480  Glutathione metabolism

# Macromolecular_Interacting_Partner_6_Reaction:
RX + glutathione = HX + R-S-glutathione

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00043:GST_C;
PF02798:GST_N

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
EC 2.5.1.18

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
306811

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
GSTA2_HUMAN (P09210)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
GSTA2

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
GSTA2

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:4627

# Macromolecular_Interacting_Partner_6_PDB_ID:
1AGS

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>669 bp
ATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATACGGGGCAGAATGGAGTCCATCCGG
TGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGAT
TTGGACAAGTTAAGAAATGATGGATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATT
GATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATTGATATGTATATAGAAGGTATAGCA
GATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACTCAACCTGAGGAACAAGATGCCAAG
CTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTA
AAGAGCCACGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTCACCTG
GTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCTAGCCTTATTTCCAGCTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCCACAGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCTTTAGAAGAATCAAGGAAGATTTTC
AGGTTTTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M16594

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_6_Locus:
6p12.1

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
3036131; 1329668; 1497629; 14574404; 8431482; 2604726; 11668220

# Macromolecular_Interacting_Partner_6_References:
15870871; 16133571; 16213016

# Macromolecular_Interacting_Partner_7_ID:
5331

# Macromolecular_Interacting_Partner_7_Name:
Alkaline phosphatase, placental-like precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Macromolecular_Interacting_Partner_7_Gene_Name:
ALPPL2

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
532

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
57378

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
6.31

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_7_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_7_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Macromolecular_Interacting_Partner_7_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Macromolecular_Interacting_Partner_7_Signals:
1-19

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 3.1.3.1

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
178428

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
PPBN_HUMAN (P10696)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ALPPL2

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ALPPL2

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:441

# Macromolecular_Interacting_Partner_7_PDB_ID:
1EW2

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
J03252

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_7_Locus:
2q37

# Macromolecular_Interacting_Partner_7_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Macromolecular_Interacting_Partner_7_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Macromolecular_Interacting_Partner_7_References:
15703838; 16465285; 17084582

# Macromolecular_Interacting_Partner_8_ID:
7599

# Macromolecular_Interacting_Partner_8_Name:
Proliferating cell nuclear antigen

# Macromolecular_Interacting_Partner_8_Synonyms:
PCNA; Cyclin

# Macromolecular_Interacting_Partner_8_Gene_Name:
PCNA

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Proliferating cell nuclear antigen
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY
RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI
KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK
IADMGHLKYYLAPKIEDEEGS

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
261

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
28769

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
4.31

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  nucleotidyltransferase activity
Function:  DNA-directed DNA polymerase activity
Function:  DNA polymerase processivity factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of DNA metabolism
Process:  regulation of DNA replication
 ||
>>>
Component:  protein complex
Component:  delta-DNA polymerase cofactor complex
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_8_General_Function:
Replication, recombination and repair 

# Macromolecular_Interacting_Partner_8_Specific_Function:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02747:PCNA_C;
PF00705:PCNA_N

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
181272

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
PCNA_HUMAN (P12004)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PCNA

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PCNA

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:8729

# Macromolecular_Interacting_Partner_8_PDB_ID:
1U76

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>786 bp
ATGTTCGAGGCGCGCCTGGTCCAGGGCTCCATCCTCAAGAAGGTGTTGGAGGCACTCAAG
GACCTCATCAACGAGGCCTGCTGGGATATTAGCTCCAGCGGTGTAAACCTGCAGAGCATG
GACTCGTCCCACGTCTCTTTGGTGCAGCTCACCCTGCGGTCTGAGGGCTTCGACACCTAC
CGCTGCGACCGCAACCTGGCCATGGGCGTGAACCTCACCAGTATGTCCAAAATACTAAAA
TGCGCCGGCAATGAAGATATCATTACACTAAGGGCCGAAGATAACGCGGATACCTTGGCG
CTAGTATTTGAAGCACCAAACCAGGAGAAAGTTTCAGACTATGAAATGAAGTTGATGGAT
TTAGATGTTGAACAACTTGGAATTCCAGAACAGGAGTACAGCTGTGTAGTAAAGATGCCT
TCTGGTGAATTTGCACGTATATGCCGAGATCTCAGCCATATTGGAGATGCTGTTGTAATT
TCCTGTGCAAAAGACGGAGTGAAATTTTCTGCAAGTGGAGAACTTGGAAATGGAAACATT
AAATTGTCACAGACAAGTAATGTCGATAAAGAGGAGGAAGCTGTTACCATAGAGATGAAT
GAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCTTTACAAAAGCCACTCCA
CTCTCTTCAACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATAAA
ATTGCGGATATGGGACACTTAAAATACTACTTGGCTCCCAAGATCGAGGATGAAGAAGGA
TCTTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M15796

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_8_Locus:
20pter-p12

# Macromolecular_Interacting_Partner_8_SNPs:
rs17350; rs17353; rs3730415; rs3626; rs8632; rs3730416; rs3730414; rs6116655; rs6116656; rs34818603; rs3730417; rs3730428; rs3730426; rs17352; rs25405; rs17347; rs17351; rs3730441; rs3730436; rs3730438; rs25406; rs17349; rs3730434; rs3730423; rs3730435; rs3730433; rs3730440; rs17348; rs3730431; rs3730427; rs3730424; rs3730437; rs3730425; rs1050525; rs36228623; rs35106260; rs11482829; rs11700149; rs10712799; rs34987280; rs10712798; rs36228616; rs34188898; rs34672771; rs11469817; rs6139626; rs6139627; rs7263456; rs11543929; rs36228622; rs6139628; rs36228617; rs36228618; rs11481769; rs35623151; rs3730432; rs35240308; rs35258130; rs6139625; rs6107578; rs3730439; rs13037111; rs16990612; rs2083918; rs2423089; rs261345; rs3729558; rs3730445; rs3730446; rs3730447; rs3730448; rs3730449; rs3730450; rs3730453; rs3730455; rs3730456; rs3761241; rs4239761; rs6053127; rs6107576; rs6107577; rs6107581; rs6116651; rs6116652; rs6116653; rs6116654; rs6139624; rs6139635; rs7264821; rs7344137; rs8122586; rs8124482; rs8125170

# Macromolecular_Interacting_Partner_8_General_References:
2882507; 2565339; 11780052; 2882422; 9305916; 9302295; 11376153; 11784855; 12522211; 8861913

# Macromolecular_Interacting_Partner_8_References:
16007142; 16160080

# Macromolecular_Interacting_Partner_9_ID:
6443

# Macromolecular_Interacting_Partner_9_Name:
Proto-oncogene tyrosine-protein kinase Src

# Macromolecular_Interacting_Partner_9_Synonyms:
p60-Src; c- Src; pp60c-src

# Macromolecular_Interacting_Partner_9_Gene_Name:
SRC

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Protooncogene tyrosineprotein kinase Src
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
536

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
59835

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
7.47

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  protein-tyrosine kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF07714:Pkinase_Tyr;
PF00017:SH2;
PF00018:SH3_1

# Macromolecular_Interacting_Partner_9_Signals:
None

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
EC 2.7.10.2

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
10635153

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
SRC_HUMAN (P12931)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
SRC

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
SRC

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:11283

# Macromolecular_Interacting_Partner_9_PDB_ID:
2SRC

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1629 bp
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC
GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG
CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG
CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC
CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG
ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACGAGGAAGGTG
GATGTCAGAGAGGGAGACTGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTAC
ATCCCCAGCAACTACGTGGCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGC
AAGATCACCAGACGGGAGTCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACC
TTCCTCGTGCGAGAAAGTGAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTC
GACAACGCCAAGGGCCTCAACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGC
TTCTACATCACCTCCCGCACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCC
AAACACGCCGATGGCCTGTGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAG
ACTCAGGGCCTGGCCAAGGATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTC
AAGCTGGGCCAGGGCTGCTTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGG
GTGGCCATCAAAACCCTGAAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCC
CAGGTCATGAAGAAGCTGAGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAG
GAGCCCATTTACATCGTCACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAG
GGGGAGACAGGCAAGTACCTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCC
TCAGGCATGGCGTACGTGGAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAAC
ATCCTGGTGGGAGAGAACCTGGTGTGCAAAGTGGCGGACTTTGGGCTGGCTCGGCTCATT
GAAGACAATGAGTACACGGCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCA
GAAGCTGCCCTCTATGGCCGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTG
CTGACTGAGCTCACCACAAAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTG
CTGGACCAGGTGGAGCGGGGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTG
CACGACCTCATGTGCCAGTGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTAC
CTGCAGGCCTTCCTGGAGGACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAG
AACCTCTAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AL133293

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_9_Locus:
20q12-q13

# Macromolecular_Interacting_Partner_9_SNPs:
rs1885257; rs744285; rs6018000; rs6018156; rs6017996; rs12329503; rs6094509; rs6018027; rs7275012; rs8126089; rs6018088; rs911496; rs6018148; rs6018199; rs6018042; rs1547836; rs6018038; rs747182; rs6018161; rs11905180; rs11697568; rs12106024; rs6090573; rs16986606; rs6017944; rs6094508; rs8117415; rs6063022; rs17785475; rs6018031; rs12480646; rs3762203; rs6012089; rs11905079; rs1547837; rs11908679; rs6063029; rs3940202; rs6090575; rs6094425; rs11907753; rs17787897; rs11906741; rs6012064; rs6066129; rs17194717; rs3762205; rs11697215; rs6090585; rs6018140; rs11904904; rs6018107; rs7269342; rs6017943; rs6018091; rs6011996; rs6018131; rs6018153; rs6017962; rs6018154; rs6017938; rs6018128; rs11908137; rs6090529; rs12479921; rs7347850; rs11908547; rs6090576; rs1573162; rs6018284; rs6018257; rs6018256; rs1570209; rs6124933; rs754625; rs11906658; rs8120573; rs6018246; rs6018233; rs2273677; rs3790149; rs10854173; rs754626; rs6018290; rs6012117; rs12233271; rs6090599; rs3790150; rs6124914; rs6017916; rs6017917; rs6017919; rs7273386; rs6011987; rs35093452; rs6018260; rs34881773; rs13036519; rs6018259; rs6018100; rs11483840; rs6094386; rs6122526; rs34905200; rs6018208; rs10535931; rs6018114; rs6066069; rs6090528; rs11468816; rs6018138; rs36003615; rs6018207; rs6094417; rs6090530; rs35008342; rs11470839; rs6124957; rs11472640; rs6018046; rs6124899; rs35931930; rs34256652; rs6122523; rs35987579; rs35694770; rs11470429; rs34071321; rs35475646; rs11470840; rs6090527; rs6090521; rs35624849; rs35282943; rs6011991; rs11479944; rs6090579; rs6094421; rs12106037; rs6017997; rs12481364; rs6066087; rs41282798; rs34939572; rs6018191; rs11450067; rs6090580; rs34795353; rs6094413; rs6090526; rs6018003; rs6094476; rs7352195; rs11086198; rs35472502; rs35466362; rs35522786; rs6066139; rs6090522; rs6066074; rs4810567; rs6017991; rs33975289; rs6124884; rs3762206; rs6018074; rs8125374; rs36113326; rs35074236; rs3762207; rs11472642; rs6090577; rs7348051; rs6066073; rs11473947; rs6094412; rs6018189; rs6066037; rs35623563; rs3078007; rs6094475; rs35528854; rs34660457; rs6066048; rs6018083; rs5841263; rs7345405; rs35422797; rs13036724; rs8117148; rs6017971; rs34916450; rs6012058; rs11697728; rs7264770; rs6066140; rs36208532; rs6017990; rs6066038; rs35784949; rs35731780; rs6094491; rs6066028; rs41282796; rs6094387; rs11467467; rs35547944; rs35732924; rs35446893; rs13043913; rs4809610; rs6063072; rs28763883; rs13039797; rs35489398; rs6124920; rs3827968; rs4810601; rs4809611; rs13043912; rs33973567; rs6124911; rs2295747; rs11475404; rs6018224; rs8115993; rs6018255; rs13038224; rs11479945; rs6122545; rs35311974; rs6066167; rs6066215; rs33926499; rs6018236; rs10714592; rs33965411; rs6018254; rs6094563; rs11467123; rs6018273; rs6124932; rs11086187; rs6094579; rs35223630; rs11474889; rs6066155; rs28763884; rs2145792; rs4810600; rs35480354; rs28763882; rs4810582; rs35182938; rs34190038; rs6063004; rs35683688; rs6094378; rs11427827; rs35612430; rs10084513; rs10084517; rs11697275; rs11905013; rs11908417; rs11908486; rs16986596; rs16986599; rs4809629; rs4810624; rs6011973; rs6017880; rs6017882; rs6017889; rs6017901; rs6017913; rs6018348; rs6018387; rs6018390; rs6018391; rs6094357; rs6094358; rs6094363; rs6094373; rs6094643; rs6122566; rs6124810; rs7272779; rs8114109; rs8117951; rs8118277; rs8118377

# Macromolecular_Interacting_Partner_9_General_References:
11780052; 3299057; 2582238; 2681803; 2581127; 12415108; 9024657; 9174343; 7532003

# Macromolecular_Interacting_Partner_9_References:
16001424; 16094635

# Macromolecular_Interacting_Partner_10_ID:
7612

# Macromolecular_Interacting_Partner_10_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_10_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_10_Signals:
1-26

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p12

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_10_References:
12622137; 14596920; 16105646

# Macromolecular_Interacting_Partner_11_ID:
7058

# Macromolecular_Interacting_Partner_11_Name:
CD44 antigen precursor

# Macromolecular_Interacting_Partner_11_Synonyms:
Phagocytic glycoprotein I; PGP-1; HUTCH-I; Extracellular matrix receptor-III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican; CDw44

# Macromolecular_Interacting_Partner_11_Gene_Name:
CD44

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>CD44 antigen precursor
MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTL
PTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFN
ASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSS
GSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQE
TWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDD
EDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWN
PEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPREDS
HSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSTT
LQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDV
TGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNR
SLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLAL
ALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSET
PDQFMTADETRNLQNVDMKIGV

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
742

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
81554

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
5.00

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  binding
Function:  pattern binding
Function:  polysaccharide binding
Function:  glycosaminoglycan binding
Function:  hyaluronic acid binding
 ||
>>>
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_11_General_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Specific_Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF00193:Xlink

# Macromolecular_Interacting_Partner_11_Signals:
1-20

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
650-670

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
180197

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CD44_HUMAN (P16070)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
CD44

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
CD44

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:1681

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>1086 bp
ATGGACAAGTTTTGGTGGCACGCAGCCTGGGGACTCTGCCTCGTGCCGCTGAGCCTGGCG
CAGATCGATTTGAATATAACCTGCCGCTTTGCAGGTGTATTCCACGTGGAGAAAAATGGT
CGCTACAGCATCTCTCGGACGGAGGCCGCTGACCTCTGCAAGGCTTTCAATAGCACCTTG
CCCACAATGGCCCAGATGGAGAAAGCTCTGAGCATCGGATTTGAGACCTGCAGGTATGGG
TTCATAGAAGGGCATGTGGTGATTCCCCGGATCCACCCCAACTCCATCTGTGCAGCAAAC
AACACAGGGGTGTACATCCTCACATACAACACCTCCCAGTATGACACATATTGCTTCAAT
GCTTCAGCTCCACCTGAAGAAGATTGTACATCAGTCACAGACCTGCCCAATGCCTTTGAT
GGACCAATTACCATAACTATTGTTAACCGTGATGGCACCCGCTATGTCCAGAAAGGAGAA
TACAGAACGAATCCTGAAGACATCTACCCCAGCAACCCTACTGATGATGACGTGAGCAGC
GGCTCCTCCAGTGAAAGGAGCAGCACTTCAGGAGGTTACATCTTTTACACCTTTTCTACT
GTACACCCCATCCCAGACGAAGACAGTCCCTGGATCACCGACAGCACAGACAGAATCCCT
GCTACCAGAGACCAAGACACATTCCACCCCAGTGGGGGGTCCCATACCACTCATGAATCT
GAATCAGATGGACACTCACATGGGAGTCAAGAAGGTGGAGCAAACACAACCTCTGGTCCT
ATAAGGACACCCCAAATTCCAGAATGGCTGATCATCTTGGCATCCCTCTTGGCCTTGGCT
TTGATTCTTGCAGTTTGCATTGCAGTCAACAGTCGAAGAAGGTGTGGGCAGAAGAAAAAG
CTAGTGATCAACAGTGGCAATGGAGCTGTGGAGGACAGAAAGCCAAGTGGACTCAACGGA
GAGGCCAGCAAGTCTCAGGAAATGGTGCATTTGGTGAACAAGGAGTCGTCAGAAACTCCA
GACCAGTTTATGACAGCTGATGAGACAAGGAACCTGCAGAATGTGGACATGAAGATTGGG
GTGTAA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
M24915

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_11_Locus:
11p13

# Macromolecular_Interacting_Partner_11_SNPs:
rs1467558; rs11607491; rs9666607; rs11033026; rs1071695; rs13347; rs10836347; rs8193; rs11821102; rs2295755; rs353558; rs353623; rs1547059; rs2295756; rs2421826; rs353627; rs932703; rs353615; rs353639; rs193276; rs353612; rs353630; rs927335; rs353629; rs353626; rs1425803; rs353620; rs353647; rs1547058; rs7934770; rs11607862; rs353642; rs3794109; rs353640; rs353634; rs10128562; rs7126359; rs996076; rs10836340; rs353632; rs353638; rs10836344; rs7105890; rs353628; rs7930549; rs353635; rs187115; rs7116739; rs10836343; rs2785172; rs7930724; rs4756195; rs353631; rs353617; rs353636; rs353618; rs102518; rs2553808; rs10128586; rs1547060; rs7110737; rs12419062; rs6484768; rs7116432; rs353643; rs353648; rs713330; rs3794105; rs2553809; rs353641; rs353646; rs16927009; rs10488810; rs4756199; rs16927100; rs3794110; rs7947433; rs2785171; rs17445923; rs10488809; rs353625; rs10488811; rs7938811; rs12577824; rs3794113; rs4755391; rs10836346; rs16927061; rs12270356; rs3736812; rs3751031; rs17375044; rs3794116; rs10836342; rs4756196; rs7945310; rs11033031; rs353644; rs2180974; rs12275533; rs12577007; rs7115768; rs17445972; rs187116; rs7937602; rs353645; rs353614; rs16926995; rs3794125; rs7952514; rs10734436; rs353633; rs112762; rs12280375; rs11822487; rs353637; rs2065006; rs4141971; rs2065004; rs11033013; rs3794107; rs10768114; rs11033021; rs353619; rs11033008; rs353624; rs2295758; rs9943592; rs16927029; rs353621; rs1981153; rs3794126; rs724474; rs7110710; rs11033019; rs1981154; rs7127087; rs3794104; rs11033010; rs7115434; rs7130549; rs6484770; rs12280381; rs12283855; rs353622; rs12420308; rs12575828; rs11820975; rs7105972; rs16926993; rs3829268; rs1474996; rs11033014; rs17446448; rs7928464; rs12272373; rs16927073; rs3794118; rs2421825; rs7932149; rs10836341; rs6484769; rs7947941; rs11033028; rs17447734; rs16927089; rs10836345; rs11033030; rs16927081; rs17447755; rs353613; rs7131335; rs11033033; rs12282190; rs7938147; rs7945284; rs919041; rs12288926; rs11033012; rs16927042; rs7952493; rs17367744; rs17446000; rs10742333; rs11605479; rs2065005; rs7934647; rs16927033; rs353616; rs7941924; rs12275472; rs6416081; rs1407822; rs3794108; rs12291025; rs11033024; rs996075; rs16926942; rs16927055; rs4141970; rs1570483; rs12362973; rs11033025; rs17367609; rs12291116; rs7111731; rs1407823; rs4755392; rs12575005; rs7944409; rs7111018; rs12273397; rs35963728; rs1058200; rs35498342; rs35911720; rs35356320; rs3198807; rs35608218; rs16927157; rs34137404; rs12293021; rs11384802; rs367229; rs2295757; rs3209774; rs5791040; rs17446427; rs11332184; rs16927120; rs35130248; rs7110041; rs11033029; rs3215691; rs36032428; rs34076207; rs12286019; rs7944818; rs11033023; rs12800786; rs35702928; rs34443928; rs374201; rs35860001; rs7952338; rs10560626; rs35747418; rs5791037; rs241494; rs34048081; rs16927093; rs2785190; rs5791042; rs35505196; rs3838798; rs12270112; rs11033020; rs3794106; rs33986625; rs7941598; rs5791039; rs35861024; rs11366759; rs724473; rs34823633; rs35437849; rs35459892; rs34853532; rs11033022; rs34175178; rs12796766; rs35501119; rs12804343; rs28454562; rs35796444; rs1065270; rs12278428; rs28675257; rs10675782; rs10610762; rs12277192; rs12285721; rs12796689; rs34932141; rs1764340; rs11607814; rs5791035; rs11340143; rs28741987; rs35650007; rs2421824; rs35464422; rs12800555; rs35605320; rs7121622; rs35792607; rs7484034; rs34784484; rs11605504; rs35043907; rs1050794; rs3047476; rs12574690; rs12795998; rs35740489; rs35334525; rs11448430; rs35138175; rs35429509; rs3829269; rs36022557; rs34848601; rs35313251; rs34187833; rs34623865; rs16927102; rs35800173; rs35978972; rs3047471; rs1321699; rs34146255; rs35941133; rs11033018; rs3047478; rs10567300; rs35342604; rs11033032; rs12785683; rs35599324; rs11428995; rs35863501; rs1885937; rs7131664; rs35302120; rs11033027; rs12365903; rs11382248; rs35217950; rs34948864; rs34453969; rs12365962; rs16927067; rs5791036; rs35852050; rs34182601; rs4141969; rs5791043; rs35914016; rs5791038; rs2295760; rs2273690; rs35414303; rs28582665; rs12791889; rs35087350; rs35953520; rs11478829; rs34292272; rs4756197; rs10718079; rs11378695; rs34207613; rs16926939; rs1186243; rs16926997; rs11600650; rs12290471; rs12365919; rs34808104; rs35251986; rs35343317; rs35040129; rs34986068; rs12577058; rs16927116; rs17445902; rs3838797; rs11825862; rs2295759; rs35251438; rs12421708; rs34847145; rs5791034; rs12796688; rs11323103; rs34837817; rs3829267; rs35112146; rs10488808; rs10488812; rs10742334; rs10742337; rs10768116; rs10768117; rs10836349; rs10836351; rs11033007; rs11033036; rs11033037; rs11822963; rs11826767; rs1425802; rs17449131; rs2180973; rs2257171; rs2732571; rs2732572; rs2732573; rs2785173; rs2785174; rs353559; rs353560; rs353566; rs353567; rs353569; rs353570; rs353571; rs395563; rs398734; rs4756193; rs4756200; rs4756201; rs598725; rs7104704; rs7105037; rs7105418; rs7105545; rs7114332; rs7115638; rs7119757; rs7122374; rs7124327; rs7934471

# Macromolecular_Interacting_Partner_11_General_References:
2466575; 1840487; 1991450; 2056274; 1281868; 1465456; 7508842; 8352881; 2466576; 2007624; 1717145; 8148709; 1922057; 9580567; 12883358; 8636151

# Macromolecular_Interacting_Partner_11_References:
15385498; 15746573; 16115366

# Macromolecular_Interacting_Partner_12_ID:
7615

# Macromolecular_Interacting_Partner_12_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_12_Synonyms:
CREB

# Macromolecular_Interacting_Partner_12_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_12_Signals:
None

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q34

# Macromolecular_Interacting_Partner_12_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_12_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_12_References:
12603604; 12670506; 15647252; 16165221

# Macromolecular_Interacting_Partner_13_ID:
7623

# Macromolecular_Interacting_Partner_13_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_13_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_13_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_13_Signals:
1-27

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_13_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_13_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_13_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_13_References:
12663497; 16456404

# Macromolecular_Interacting_Partner_14_ID:
7628

# Macromolecular_Interacting_Partner_14_Name:
Nuclear factor NF-kappa-B p105 subunit

# Macromolecular_Interacting_Partner_14_Synonyms:
DNA-binding factor KBF1; EBP- 1[Contains: Nuclear factor NF-kappa-B p50 subunit]

# Macromolecular_Interacting_Partner_14_Gene_Name:
NFKB1

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Nuclear factor NFkappaB p105 subunit
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
968

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
105357

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
5.05

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  protein binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur posttranslationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF00023:Ank;
PF00531:Death;
PF00554:RHD;
PF01833:TIG

# Macromolecular_Interacting_Partner_14_Signals:
None

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
189180

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
NFKB1_HUMAN (P19838)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
NFKB1

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
NFKB1

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:7794

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B)

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>2910 bp
ATGGCAGAAGATGATCCATATTTGGGAAGGCCTGAACAAATGTTTCATTTGGATCCTTCT
TTGACTCATACAATATTTAATCCAGAAGTATTTCAACCACAGATGGCACTGCCAACAGCA
GATGGCCCATACCTTCAAATATTAGAGCAACCTAAACAGAGAGGATTTCGTTTCCGTTAT
GTATGTGAAGGCCCATCCCATGGTGGACTACCTGGTGCCTCTAGTGAAAAGAACAAGAAG
TCTTACCCTCAGGTCAAAATCTGCAACTATGTGGGACCAGCAAAGGTTATTGTTCAGTTG
GTCACAAATGGAAAAAATATCCACCTGCATGCCCACAGCCTGGTGGGAAAACACTGTGAG
GATGGGATCTGCACTGTAACTGCTGGACCCAAGGACATGGTGGTCGGCTTCGCAAACCTG
GGTATACTTCATGTGACAAAGAAAAAAGTATTTGAAACACTGGAAGCACGAATGACAGAG
GCGTGTATAAGGGGCTATAATCCTGGACTCTTGGTGCACCCTGACCTTGCCTATTTGCAA
GCAGAAGGTGGAGGGGACCGGCAGCTGGGAGATCGGGAAAAAGAGCTAATCCGCCAAGCA
GCTCTGCAGCAGACCAAGGAGATGGACCTCAGCGTGGTGCGGCTCATGTTTACAGCTTTT
CTTCCGGATAGCACTGGCAGCTTCACAAGGCGCCTGGAACCCGTGGTATCAGACGCCATC
TATGACAGTAAAGCCCCCAATGCATCCAACTTGAAAATTGTAAGAATGGACAGGACAGCT
GGATGTGTGACTGGAGGGGAGGAAATTTATCTTCTTTGTGACAAAGTTCAGAAAGATGAC
ATCCAGATTCGATTTTATGAAGAGGAAGAAAATGGTGGAGTCTGGGAAGGATTTGGAGAT
TTTTCCCCCACAGATGTTCATAGACAATTTGCCATTGTCTTCAAAACTCCAAAGTATAAA
GATATTAATATTACAAAACCAGCCTCTGTGTTTGTCCAGCTTCGGAGGAAATCTGACTTG
GAAACTAGTGAACCAAAACCTTTCCTCTACTATCCTGAAATCAAAGATAAAGAAGAAGTG
CAGAGGAAACGTCAGAAGCTCATGCCCAATTTTTCGGATAGTTTCGGCGGTGGTAGTGGT
GCCGGAGCTGGAGGCGGAGGCATGTTTGGTAGTGGCGGTGGAGGAGGGGGCACTGGAAGT
ACAGGTCCAGGGTATAGCTTCCCACACTATGGATTTCCTACTTATGGTGGGATTACTTTC
CATCCTGGAACTACTAAATCTAATGCTGGGATGAAGCATGGAACCATGGACACTGAATCT
AAAAAGGACCCTGAAGGTTGTGACAAAAGTGATGACAAAAACACTGTAAACCTCTTTGGG
AAAGTTATTGAAACCACAGAGCAAGATCAGGAGCCCAGCGAGGCCACCGTTGGGAATGGT
GAGGTCACTCTAACGTATGCAACAGGAACAAAAGAAGAGAGTGCTGGAGTTCAGGATAAC
CTCTTTCTAGAGAAGGCTATGCAGCTTGCAAAGAGGCATGCCAATGCCCTTTTCGACTAC
GCGGTGACAGGAGACGTGAAGATGCTGCTGGCCGTCCAGCGCCATCTCACTGCTGTGCAG
GATGAGAATGGGGACAGTGTCTTACACTTAGCAATCATCCACCTTCATTCTCAACTTGTG
AGGGATCTACTAGAAGTCACATCTGGTTTGATTTCTGATGACATTATCAACATGAGAAAT
GATCTGTACCAGACGCCCTTGCACTTGGCAGTGATCACTAAGCAGGAAGATGTGGTGGAG
GATTTGCTGAGGGCTGGGGCCGACCTGAGCCTTCTGGACCGCTTGGGTAACTCTGTTTTG
CACCTAGCTGCCAAAGAAGGACATGATAAAGTTCTCAGTATCTTACTCAAGCACAAAAAG
GCAGCACTACTTCTTGACCACCCCAACGGGGACGGTCTGAATGCCATTCATCTAGCCATG
ATGAGCAATAGCCTGCCATGTTTGCTGCTGCTGGTGGCCGCTGGGGCTGACGTCAATGCT
CAGGAGCAGAAGTCCGGGCGCACAGCACTGCACCTGGCTGTGGAGCACGACAACATCTCA
TTGGCAGGCTGCCTGCTCCTGGAGGGTGATGCCCATGTGGACAGTACTACCTACGATGGA
ACCACACCCCTGCATATAGCAGCTGGGAGAGGGTCCACCAGGCTGGCAGCTCTTCTCAAA
GCAGCAGGAGCAGATCCCCTGGTGGAGAACTTTGAGCCTCTCTATGACCTGGATGACTCT
TGGGAAAATGCAGGAGAGGATGAAGGAGTTGTGCCTGGAACCACGCCTCTAGATATGGCC
ACCAGCTGGCAGGTATTTGACATATTAAATGGGAAACCATATGAGCCAGAGTTTACATCT
GATGATTTACTAGCACAAGGAGACATGAAACAGCTGGCTGAAGATGTGAAGCTGCAGCTG
TATAAGTTACTAGAAATTCCTGATCCAGACAAAAACTGGGCTACTCTGGCGCAGAAATTA
GGTCTGGGGATACTTAATAATGCCTTCCGGCTGAGTCCTGCTCCTTCCAAAACACTTATG
GACAACTATGAGGTCTCTGGGGGTACAGTCAGAGAGCTGGTGGAGGCCCTGAGACAAATG
GGCTACACCGAAGCAATTGAAGTGATCCAGGCAGCCTCCAGCCCAGTGAAGACCACCTCT
CAGGCCCACTCGCTGCCTCTCTCGCCTGCCTCCACAAGGCAGCAAATAGACGAGCTCCGA
GACAGTGACAGTGTCTGCGACACGGGCGTGGAGACATCCTTCCGCAAACTCAGCTTTACC
GAGTCTCTGACCAGTGGTGCCTCACTGCTAACTCTCAACAAAATGCCCCATGATTATGGG
CAGGAAGGACCTCTAGAAGGCAAAATTTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
M55643

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_14_Locus:
4q24

# Macromolecular_Interacting_Partner_14_SNPs:
rs4648099; rs4648072; rs4648085; rs1609993; rs4648109; rs4648094; rs4648093; rs1599961; rs1585213; rs1585214; rs1585215; rs230537; rs1598857; rs3774932; rs230536; rs4647980; rs4647968; rs3774938; rs1598856; rs3774934; rs3774937; rs4647972; rs3774933; rs3774936; rs4647981; rs17032720; rs17032705; rs4648144; rs4647978; rs4647970; rs2168803; rs35630491; rs6841533; rs4647965; rs34802427; rs11934404; rs4235404; rs1120986; rs4648143; rs10013613; rs41275743; rs35566216; rs4647983; rs4647975; rs4647966; rs17032740; rs1801; rs230544; rs170731; rs230494; rs93059; rs118882; rs1609798; rs230505; rs230491; rs230547; rs1020760; rs230504; rs230498; rs230521; rs230492; rs230526; rs230510; rs1598859; rs4648141; rs230522; rs909332; rs4648058; rs230496; rs230535; rs230527; rs1005819; rs230541; rs230512; rs4235405; rs909331; rs3774960; rs4648135; rs4648050; rs4699031; rs230511; rs3821958; rs230525; rs3774967; rs230495; rs11722146; rs1598861; rs230534; rs3774963; rs230520; rs3774956; rs230493; rs230529; rs230517; rs4699030; rs230507; rs3755867; rs3774959; rs230499; rs3774964; rs4648002; rs1287; rs230530; rs230497; rs4235406; rs1020759; rs4648052; rs7683854; rs4647992; rs230539; rs2293970; rs4648116; rs4648069; rs230519; rs3817685; rs4648011; rs13117745; rs230500; rs728440; rs4648131; rs4648095; rs4648127; rs230509; rs12509403; rs4648016; rs4648101; rs4648036; rs4648079; rs3774957; rs4648068; rs9790601; rs230538; rs4648059; rs4648102; rs230523; rs7684888; rs1610152; rs4648013; rs4648018; rs35628038; rs4648064; rs4648024; rs4648055; rs4648073; rs230528; rs4648049; rs230540; rs11723120; rs4648082; rs230542; rs4648062; rs4648108; rs4648006; rs4648107; rs4648137; rs3774968; rs1598858; rs230532; rs10489114; rs4648034; rs4648104; rs4648045; rs4648132; rs7340881; rs4648090; rs3083182; rs7667496; rs4648133; rs4648051; rs4648110; rs12509517; rs3774965; rs17032779; rs4648022; rs4648056; rs4648004; rs4648057; rs230531; rs230533; rs4648125; rs4648142; rs230518; rs17032781; rs4648015; rs4648134; rs4648130; rs34670343; rs4648037; rs4648128; rs4648091; rs4648043; rs17032850; rs4698858; rs7679591; rs4648123; rs4647997; rs17032920; rs4648008; rs3774966; rs4648009; rs230506; rs4648047; rs17032763; rs230516; rs4648038; rs4648060; rs4648113; rs4648117; rs4647991; rs11097789; rs35226141; rs4648136; rs4648106; rs4648063; rs4648122; rs4648029; rs230543; rs4648044; rs7654805; rs4648032; rs4648087; rs12509950; rs41477752; rs230513; rs36205989; rs4648040; rs4648126; rs4647987; rs34263415; rs725200; rs4648103; rs4647995; rs4648121; rs12641009; rs4648080; rs4648046; rs17032830; rs10023807; rs4648023; rs4648083; rs35121130; rs230514; rs230502; rs35857972; rs4648075; rs35822193; rs4648010; rs4648035; rs4648138; rs4648115; rs9996972; rs4648088; rs17032815; rs4648092; rs4648098; rs230503; rs4648084; rs4648026; rs17032771; rs230501; rs230515; rs6819573; rs35750259; rs4648111; rs4648096; rs4648129; rs4648053; rs11940017; rs28362491; rs16996774; rs11944443; rs4648086; rs4648065; rs4648118; rs41341444; rs11556612; rs4648003; rs41452949; rs1804009; rs4648119; rs4648039; rs3938376; rs2272676; rs13132317; rs34257045; rs11303983; rs35129546; rs4647969; rs4648145; rs4647974; rs35726481; rs3774935; rs34381316; rs28673338; rs4623003; rs4647967; rs4380526; rs4299585; rs4647973; rs34401471; rs35477220; rs4647977; rs13131592; rs2926005; rs35136542; rs6834596; rs13137392; rs34333104; rs961296; rs2103487; rs28677850; rs13104462; rs35014169; rs34022549; rs4647976; rs11556613; rs13147479; rs4647979; rs4647971; rs4648146; rs28520385; rs28484580; rs13132517; rs4647982; rs34126565; rs11728039; rs17234923; rs13132318; rs34926856; rs4648019; rs34021443; rs7440719; rs36217876; rs33911444; rs7682845; rs11397781; rs34233927; rs33948657; rs35606145; rs11368940; rs35791621; rs4648112; rs4648021; rs4647984; rs35444371; rs41452347; rs41469748; rs7679842; rs230524; rs34439575; rs6836486; rs10031217; rs4538482; rs4648078; rs34308797; rs4648054; rs4648097; rs4648139; rs1902849; rs4648031; rs10024951; rs28595328; rs7692606; rs11451855; rs41487649; rs647424; rs28406704; rs4648074; rs35886550; rs3774944; rs3830689; rs4648020; rs4648025; rs4648081; rs41275741; rs35031468; rs34771751; rs34933613; rs11320580; rs13149243; rs230508; rs11723768; rs34299444; rs35449997; rs35215784; rs4647999; rs35715251; rs34384275; rs4647998; rs41430146; rs41520150; rs28557116; rs4648012; rs13124438; rs4648077; rs41341146; rs34651181; rs4698859; rs3796408; rs4648048; rs4648033; rs34879511; rs4648007; rs9942301; rs28610412; rs11452345; rs6833549; rs3774951; rs34029484; rs3836563; rs4648140; rs34646774; rs28450894; rs35186646; rs34757231; rs28485089; rs4647985; rs35340745; rs34837589; rs4648076; rs4648028; rs4648089; rs34134600; rs36017625; rs3836562; rs35795162; rs35153016; rs11724677; rs4647994; rs4648030; rs35906490; rs35429536; rs4648017; rs4648114; rs4648071; rs35323892; rs34467687; rs4648041; rs10428399; rs10013190; rs35022229; rs34779942; rs4647989; rs12645604; rs7687966; rs4648014; rs4647988; rs35342982; rs3836564; rs11296045; rs35504484; rs11336046; rs34028525; rs35698833; rs11931621; rs12510977; rs7693670; rs34092684; rs35680095; rs4648067; rs647417; rs6843970; rs230546; rs35803083; rs28491436; rs4648061; rs4647986; rs4648027; rs4648120; rs4647996; rs33930729; rs4647990; rs34074793; rs9790373; rs3796409; rs34122180; rs35185023; rs4648042; rs4648070; rs3836561; rs2125212; rs4648005; rs4647993; rs36051664; rs34587686; rs4648124; rs3774961; rs28440950; rs33964959; rs3834210; rs4648105; rs4648066; rs4648001; rs35157203; rs10711129; rs11449359; rs28566809; rs35037058; rs10585671; rs6834974; rs13129088; rs4648000; rs4648100; rs28591630; rs34726463; rs11726195; rs36226652; rs11940065; rs4648147; rs35897145; rs34425291; rs10647550; rs6819775; rs35040256; rs10489113; rs11733293; rs12505960; rs12644738; rs12648696; rs17032985; rs17032989; rs17032996; rs17033015; rs4698860; rs4698861; rs4698862; rs4698863; rs747559; rs7674640; rs980455; rs997476

# Macromolecular_Interacting_Partner_14_General_References:
2203531; 2234062; 1992489; 8825636; 8087845; 8628291; 9529257; 10469655; 9950430; 10970863; 11094166; 11468175; 11297557; 12393603; 7830764; 9865693

# Macromolecular_Interacting_Partner_14_References:
12917341; 15145607; 15950952

# Macromolecular_Interacting_Partner_15_ID:
6559

# Macromolecular_Interacting_Partner_15_Name:
Mitogen-activated protein kinase 3

# Macromolecular_Interacting_Partner_15_Synonyms:
Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAPK 1; p44-ERK1; ERT2; p44-MAPK; Microtubule- associated protein 2 kinase

# Macromolecular_Interacting_Partner_15_Gene_Name:
MAPK3

# Macromolecular_Interacting_Partner_15_Protein_Sequence:
>Mitogenactivated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP

# Macromolecular_Interacting_Partner_15_Number_of_Residues:
379

# Macromolecular_Interacting_Partner_15_Molecular_Weight:
43136

# Macromolecular_Interacting_Partner_15_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_15_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_15_General_Function:
Not Available

# Macromolecular_Interacting_Partner_15_Specific_Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1

# Macromolecular_Interacting_Partner_15_Pathway:
Not Available

# Macromolecular_Interacting_Partner_15_Reaction:
Not Available

# Macromolecular_Interacting_Partner_15_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_15_Signals:
None

# Macromolecular_Interacting_Partner_15_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_15_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_15_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_15_GenBank_ID_Protein:
31221

# Macromolecular_Interacting_Partner_15_SwissProt_ID:
MK03_HUMAN (P27361)

# Macromolecular_Interacting_Partner_15_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_15_Genecard_id:
MAPK3

# Macromolecular_Interacting_Partner_15_Geneatlas_id:
MAPK3

# Macromolecular_Interacting_Partner_15_hgnc_id:
HGNC:6877

# Macromolecular_Interacting_Partner_15_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_15_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_15_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_15_Gene_Sequence:
>1140 bp
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCAGCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGCCA
GTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGATGACCTACCTAAGGAGCGGCTG
AAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTAG


# Macromolecular_Interacting_Partner_15_GenBank_ID_Gene:
X60188

# Macromolecular_Interacting_Partner_15_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_15_Locus:
16p11.2

# Macromolecular_Interacting_Partner_15_SNPs:
rs1143695; rs11865086; rs11864737; rs9921806; rs12922100; rs11863765; rs9930013; rs11546680; rs41292376; rs41291696; rs41280862; rs35691465; rs41280866; rs41280860; rs41280864; rs35666305; rs11644927; rs7199920; rs12918285; rs36084237; rs34799400; rs34564246; rs9940575; rs9940581; rs28529403; rs1042404; rs1062543; rs12924137; rs12930241; rs13569; rs1561414; rs2005219; rs3751867; rs7542; rs7698; rs8061772

# Macromolecular_Interacting_Partner_15_General_References:
7687743; 1540184; 1319925; 8794306

# Macromolecular_Interacting_Partner_15_References:
12670506; 16854387

# Macromolecular_Interacting_Partner_16_ID:
7653

# Macromolecular_Interacting_Partner_16_Name:
Catenin beta-1

# Macromolecular_Interacting_Partner_16_Synonyms:
Beta-catenin

# Macromolecular_Interacting_Partner_16_Gene_Name:
CTNNB1

# Macromolecular_Interacting_Partner_16_Protein_Sequence:
>Catenin beta1
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L

# Macromolecular_Interacting_Partner_16_Number_of_Residues:
781

# Macromolecular_Interacting_Partner_16_Molecular_Weight:
85498

# Macromolecular_Interacting_Partner_16_Theoretical_pI:
5.71

# Macromolecular_Interacting_Partner_16_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_16_General_Function:
Not Available

# Macromolecular_Interacting_Partner_16_Specific_Function:
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway

# Macromolecular_Interacting_Partner_16_Pathway:
Not Available

# Macromolecular_Interacting_Partner_16_Reaction:
Not Available

# Macromolecular_Interacting_Partner_16_Pfam_Domain_Function:
PF00514:Arm;
PF02985:HEAT

# Macromolecular_Interacting_Partner_16_Signals:
None

# Macromolecular_Interacting_Partner_16_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_16_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_16_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_16_GenBank_ID_Protein:
860988

# Macromolecular_Interacting_Partner_16_SwissProt_ID:
CTNB1_HUMAN (P35222)

# Macromolecular_Interacting_Partner_16_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_16_Genecard_id:
CTNNB1

# Macromolecular_Interacting_Partner_16_Geneatlas_id:
CTNNB1

# Macromolecular_Interacting_Partner_16_hgnc_id:
HGNC:2514

# Macromolecular_Interacting_Partner_16_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_16_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_16_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation

# Macromolecular_Interacting_Partner_16_Gene_Sequence:
>2346 bp
ATGGCTACTCAAGCTGATTTGATGGAGTTGGACATGGCCATGGAACCAGACAGAAAAGCG
GCTGTTAGTCACTGGCAGCAACAGTCTTACCTGGACTCTGGAATCCATTCTGGTGCCACT
ACCACAGCTCCTTCTCTGAGTGGTAAAGGCAATCCTGAGGAAGAGGATGTGGATACCTCC
CAAGTCCTGTATGAGTGGGAACAGGGATTTTCTCAGTCCTTCACTCAAGAACAAGTAGCT
GATATTGATGGACAGTATGCAATGACTCGAGCTCAGAGGGTACGAGCTGCTATGTTCCCT
GAGACATTAGATGAGGGCATGCAGATCCCATCTACACAGTTTGATGCTGCTCATCCCACT
AATGTCCAGCGTTTGGCTGAACCATCACAGATGCTGAAACATGCAGTTGTAAACTTGATT
AACTATCAAGATGATGCAGAACTTGCCACACGTGCAATCCCTGAACTGACAAAACTGCTA
AATGACGAGGACCAGGTGGTGGTTAATAAGGCTGCAGTTATGGTCCATCAGCTTTCTAAA
AAGGAAGCTTCCAGACACGCTATCATGCGTTCTCCTCAGATGGTGTCTGCTATTGTACGT
ACCATGCAGAATACAAATGATGTAGAAACAGCTCGTTGTACCGCTGGGACCTTGCATAAC
CTTTCCCATCATCGTGAGGGCTTACTGGCCATCTTTAAGTCTGGAGGCATTCCTGCCCTG
GTGAAAATGCTTGGTTCACCAGTGGATTCTGTGTTGTTTTATGCCATTACAACTCTCCAC
AACCTTTTATTACATCAAGAAGGAGCTAAAATGGCAGTGCGTTTAGCTGGTGGGCTGCAG
AAAATGGTTGCCTTGCTCAACAAAACAAATGTTAAATTCTTGGCTATTACGACAGACTGC
CTTCAAATTTTAGCTTATGGCAACCAAGAAAGCAAGCTCATCATACTGGCTAGTGGTGGA
CCCCAAGCTTTAGTAAATATAATGAGGACCTATACTTACGAAAAACTACTGTGGACCACA
AGCAGAGTGCTGAAGGTGCTATCTGTCTGCTCTAGTAATAAGCCGGCTATTGTAGAAGCT
GGTGGAATGCAAGCTTTAGGACTTCACCTGACAGATCCAAGTCAACGTCTTGTTCAGAAC
TGTCTTTGGACTCTCAGGAATCTTTCAGATGCTGCAACTAAACAGGAAGGGATGGAAGGT
CTCCTTGGGACTCTTGTTCAGCTTCTGGGTTCAGATGATATAAATGTGGTCACCTGTGCA
GCTGGAATTCTTTCTAACCTCACTTGCAATAATTATAAGAACAAGATGATGGTCTGCCAA
GTGGGTGGTATAGAGGCTCTTGTGCGTACTGTCCTTCGGGCTGGTGACAGGGAAGACATC
ACTGAGCCTGCCATCTGTGCTCTTCGTCATCTGACCAGCCGACACCAAGAAGCAGAGATG
GCCCAGAATGCAGTTCGCCTTCACTATGGACTACCAGTTGTGGTTAAGCTCTTACACCCA
CCATCCCACTGGCCTCTGATAAAGGCTACTGTTGGATTGATTCGAAATCTTGCCCTTTGT
CCCGCAAATCATGCACCTTTGCGTGAGCAGGGTGCCATTCCACGACTAGTTCAGTTGCTT
GTTCGTGCACATCAGGATACCCAGCGCCGTACGTCCATGGGTGGGACACAGCAGCAATTT
GTGGAGGGGGTCCGCATGGAAGAAATAGTTGAAGGTTGTACCGGAGCCCTTCACATCCTA
GCTCGGGATGTTCACAACCGAATTGTTATCAGAGGACTAAATACCATTCCATTGTTTGTG
CAGCTGCTTTATTCTCCCATTGAAAACATCCAAAGAGTAGCTGCAGGGGTCCTCTGTGAA
CTTGCTCAGGACAAGGAAGCTGCAGAAGCTATTGAAGCTGAGGGAGCCACAGCTCCTCTG
ACAGAGTTACTTCACTCTAGGAATGAAGGTGTGGCGACATATGCAGCTGCTGTTTTGTTC
CGAATGTCTGAGGACAAGCCACAAGATTACAAGAAACGGCTTTCAGTTGAGCTGACCAGC
TCTCTCTTCAGAACAGAGCCAATGGCTTGGAATGAGACTGCTGATCTTGGACTTGATATT
GGTGCCCAGGGAGAACCCCTTGGATATCGCCAGGATGATCCTAGCTATCGTTCTTTTCAC
TCTGGTGGATATGGCCAGGATGCCTTGGGTATGGACCCCATGATGGAACATGAGATGGGT
GGCCACCACCCTGGTGCTGACTATCCAGTTGATGGGCTGCCAGATCTGGGGCATGCCCAG
GACCTCATGGATGGGCTGCCTCCAGGTGACAGCAATCAGCTGGCCTGGTTTGATACTGAC
CTGTAA

# Macromolecular_Interacting_Partner_16_GenBank_ID_Gene:
X87838

# Macromolecular_Interacting_Partner_16_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_16_Locus:
3p21

# Macromolecular_Interacting_Partner_16_SNPs:
rs4135384; rs3856746; rs3856747; rs2293303; rs1800663; rs4135379; rs3856748; rs9813198; rs2953; rs4533622; rs4016435; rs1798794; rs6776881; rs9867787; rs4973927; rs3915129; rs2371452; rs2140090; rs4135367; rs6792748; rs4135368; rs1798802; rs3834205; rs12492719; rs13075993; rs1722845; rs13072632; rs11564437; rs11129892; rs11920550; rs11564443; rs4135387; rs4135370; rs17199505; rs2371453; rs4973928; rs9872966; rs4135243; rs17054111; rs13076290; rs5743390; rs9820313; rs11708064; rs16339; rs11928435; rs11564440; rs4135388; rs4974075; rs5743383; rs11564436; rs4135366; rs4135374; rs2293302; rs3774371; rs1880481; rs3774369; rs5743391; rs11564474; rs11564447; rs11564477; rs2276826; rs4135385; rs4135381; rs11564473; rs5743395; rs11564445; rs11564446; rs11564450; rs3774370; rs11564475; rs11564465; rs11564478; rs11564456; rs11564459; rs11564460; rs11564464; rs13096546; rs11564461; rs11564463; rs11564458; rs11564467; rs11564452; rs11564448; rs11564454; rs11564468; rs11564453; rs17266083; rs11564457; rs3864004; rs11564431; rs11564486; rs11564430; rs28931588; rs28931589; rs35288908; rs4135386; rs5743392; rs13086686; rs34343353; rs35901713; rs35025041; rs5743389; rs34565533; rs4135244; rs35003074; rs11564439; rs34243856; rs11564442; rs4135365; rs35024316; rs3207381; rs28531867; rs1798792; rs34745712; rs11720097; rs11457773; rs11564438; rs5743386; rs11564435; rs4135373; rs11425223; rs34534133; rs1722851; rs13067975; rs34854135; rs11914865; rs3207382; rs5743385; rs11564434; rs7372252; rs4135372; rs1058355; rs10576683; rs34653633; rs11564479; rs35012062; rs11564441; rs4135371; rs35801414; rs4135389; rs5743384; rs4135369; rs4135375; rs5743387; rs34341265; rs34212725; rs35952434; rs35584784; rs1057513; rs35164905; rs13067968; rs34283755; rs35313837; rs17050830; rs4135376; rs35166040; rs11720409; rs35334729; rs4135378; rs3836494; rs11377041; rs1628844; rs11564470; rs11564451; rs35461809; rs2691680; rs10574857; rs11564449; rs35570424; rs11564476; rs35907471; rs11564455; rs34525870; rs3038134; rs11564472; rs11564469; rs11564462; rs4135380; rs5743393; rs11564444; rs11423812; rs4135377; rs5743396; rs11564466; rs11564471; rs4135382; rs7629538; rs33960177; rs36114955; rs5743394; rs35433269; rs2177140; rs34864544; rs35071363; rs3821833; rs11564428; rs3841963; rs11564487; rs11564483; rs11564488; rs9848755; rs11564433; rs11564484; rs11564429; rs11564432; rs11564485; rs35523547; rs11129895; rs11564490; rs11564491; rs11564492; rs11708951; rs11711946; rs11713042; rs11716602; rs12488691; rs12492279; rs13317032; rs2228683; rs2272216; rs2293304; rs2293305; rs2371485; rs2653480; rs4974074; rs6769117; rs6803275; rs7634002; rs9311265; rs9824212; rs9859392; rs9870255; rs9872276; rs9872571; rs9883073; rs9883839

# Macromolecular_Interacting_Partner_16_General_References:
7806582; 12019147; 10187801; 10966653; 11751639; 11279024; 11590244; 11389839; 12051714; 12297051; 12027456; 11834740; 12077367; 12830000; 10679188; 11136974; 11713475; 11713476; 12408824

# Macromolecular_Interacting_Partner_16_References:
15930180; 16717102

# Macromolecular_Interacting_Partner_17_ID:
6214

# Macromolecular_Interacting_Partner_17_Name:
Nitric oxide synthase, inducible

# Macromolecular_Interacting_Partner_17_Synonyms:
NOS type II; Inducible NO synthase; Inducible NOS; iNOS; Hepatocyte NOS; HEP- NOS

# Macromolecular_Interacting_Partner_17_Gene_Name:
NOS2A

# Macromolecular_Interacting_Partner_17_Protein_Sequence:
>Nitric oxide synthase, inducible
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL

# Macromolecular_Interacting_Partner_17_Number_of_Residues:
1153

# Macromolecular_Interacting_Partner_17_Molecular_Weight:
131119

# Macromolecular_Interacting_Partner_17_Theoretical_pI:
8.01

# Macromolecular_Interacting_Partner_17_GO_Classification:
>>>
Function:  cofactor binding
Function:  coenzyme binding
Function:  NADP binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  protein binding
Function:  calmodulin binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  monooxygenase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen
Function:  nitric-oxide synthase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
Function:  transporter activity
Function:  electron transporter activity
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  biosynthesis
Process:  nitric oxide biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_17_General_Function:
Inorganic ion transport and metabolism 

# Macromolecular_Interacting_Partner_17_Specific_Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions

# Macromolecular_Interacting_Partner_17_Pathway:
map00330  Arginine and proline metabolism

# Macromolecular_Interacting_Partner_17_Reaction:
L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+

# Macromolecular_Interacting_Partner_17_Pfam_Domain_Function:
PF00667:FAD_binding_1;
PF00258:Flavodoxin_1;
PF00175:NAD_binding_1;
PF02898:NO_synthase

# Macromolecular_Interacting_Partner_17_Signals:
None

# Macromolecular_Interacting_Partner_17_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_17_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_17_EC_Link:
EC 1.14.13.39

# Macromolecular_Interacting_Partner_17_GenBank_ID_Protein:
292242

# Macromolecular_Interacting_Partner_17_SwissProt_ID:
NOS2A_HUMAN (P35228)

# Macromolecular_Interacting_Partner_17_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_17_Genecard_id:
NOS2A

# Macromolecular_Interacting_Partner_17_Geneatlas_id:
NOS2A

# Macromolecular_Interacting_Partner_17_hgnc_id:
HGNC:7873

# Macromolecular_Interacting_Partner_17_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_17_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_17_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_17_Gene_Sequence:
>3462 bp
ATGGCCTGTCCTTGGAAATTTCTGTTCAAGACCAAATTCCACCAGTATGCAATGAATGGG
GAAAAAGACATCAACAACAATGTGGAGAAAGCCCCCTGTGCCACCTCCAGTCCAGTGACA
CAGGATGACCTTCAGTATCACAACCTCAGCAAGCAGCAGAATGAGTCCCCGCAGCCCCTC
GTGGAGACGGGAAAGAAGTCTCCAGAATCTCTGGTCAAGCTGGATGCAACCCCATTGTCC
TCCCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGGATGACTTTCCAAGACACACTT
CACCATAAGGCCAAAGGGATTTTAACTTGCAGGTCCAAATCTTGCCTGGGGTCCATTATG
ACTCCCAAAAGTTTGACCAGAGGACCCAGGGACAAGCCTACCCCTCCAGATGAGCTTCTA
CCTCAAGCTATCGAATTTGTCAACCAATATTACGGCTCCTTCAAAGAGGCAAAAATAGAG
GAACATCTGGCCAGGGTGGAAGCGGTAACAAAGGAGATAGAAACAACAGGAACCTACCAA
CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAATGCCCCACGCTGC
ATTGGGAGGATCCAGTGGTCCAACCTGCAGGTCTTCGATGCCCGCAGCTGTTCCACTGCC
CGGGAAATGTTTGAACACATCTGCAGACACGTGCGTTACTCCACCAACAATGGCAACATC
AGGTCGGCCATCACCGTGTTCCCCCAGCGGAGTGATGGCAAGCACGACTTCCGGGTGTGG
AATGCTCAGCTCATCCGCTATGCTGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC
CCTGCCAACGTGGAATTCACTCAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC
CGCTTCGATGTGGTCCCCCTGGTCCTGCAGGCCAATGGCCGTGACCCTGAGCTCTTCGAA
ATCCCACCTGACCTTGTGCTTGAGGTGGCCATGGAACATCCCAAATACGAGTGGTTTCGG
GAACTGGAGCTAAAGTGGTACGCCCTGCCTGCAGTGGCCAACATGCTGCTTGAGGTGGGC
GGCCTGGAGTTCCCAGGGTGCCCCTTCAATGGCTGGTACATGGGCACAGAGATCGGAGTC
CGGGACTTCTGTGACGTCCAGCGCTACAACATCCTGGAGGAAGTGGGCAGGAGAATGGGC
CTGGAAACGCACAAGCTGGCCTCGCTCTGGAAAGACCAGGCTGTCGTTGAGATCAACATT
GCTGTGATCCATAGTTTTCAGAAGCAGAATGTGACCATCATGGACCACCACTCGGCTGCA
GAATCCTTCATGAAGTACATGCAGAATGAATACCGGTCCCGTGGGGGCTGCCCGGCAGAC
TGGATTTGGCTGGTCCCTCCCATGTCTGGGAGCATCACCCCCGTGTTTCACCAGGAGATG
CTGAACTACGTCCTGTCCCCTTTCTACTACTATCAGGTAGAGGCCTGGAAAACCCATGTC
TGGCAGGACGAGAAGCGGAGACCCAAGAGAAGAGAGATTCCATTGAAAGTCTTGGTCAAA
GCTGTGCTCTTTGCCTGTATGCTGATGCGCAAGACAATGGCGTCCCGAGTCAGAGTCACC
ATCCTCTTTGCGACAGAGACAGGAAAATCAGAGGCGCTGGCCTGGGACCTGGGGGCCTTA
TTCAGCTGTGCCTTCAACCCCAAGGTTGTCTGCATGGATAAGTACAGGCTGAGCTGCCTG
GAGGAGGAACGGCTGCTGTTGGTGGTGACCAGTACGTTTGGCAATGGAGACTGCCCTGGC
AATGGAGAGAAACTGAAGAAATCGCTCTTCATGCTGAAAGAGCTCAACAACAAATTCAGG
TACGCTGTGTTTGGCCTCGGCTCCAGCATGTACCCTCGGTTCTGCGCCTTTGCTCATGAC
ATTGATCAGAAGCTGTCCCACCTGGGGGCCTCTCAGCTCACCCCGATGGGAGAAGGGGAT
GAGCTCAGTGGGCAGGAGGACGCCTTCCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC
TGTGAGACGTTTGATGTCCGAGGCAAACAGCACATTCAGATCCCCAAGCTCTACACCTCC
AATGTGACCTGGGACCCGCACCACTACAGGCTCGTGCAGGACTCACAGCCTTTGGACCTC
AGCAAAGCCCTCAGCAGCATGCATGCCAAGAACGTGTTCACCATGAGGCTCAAATCTCGG
CAGAATCTACAAAGTCCGACATCCAGCCGTGCCACCATCCTGGTGGAACTCTCCTGTGAG
GATGGCCAAGGCCTGAACTACCTGCCGGGGGAGCACCTTGGGGTTTGCCCAGGCAACCAG
CCGGCCCTGGTCCAAGGCATCCTGGAGCGAGTGGTGGATGGCCCCACACCCCACCAGACA
GTGCGCCTGGAGGACCTGGATGAGAGTGGCAGCTACTGGGTCAGTGACAAGAGGCTGCCC
CCCTGCTCACTCAGCCAGGCCCTCACCTACTCCCCGGACATCACCACACCCCCAACCCAG
CTGCTGCTCCAAAAGCTGGCCCAGGTGGCCACAGAAGAGCCTGAGAGACAGAGGCTGGAG
GCCCTGTGCCAGCCCTCAGAGTACAGCAAGTGGAAGTTCACCAACAGCCCCACATTCCTG
GAGGTGCTAGAGGAGTTCCCGTCCCTGCGGGTGTCTGCTGGCTTCCTGCTTTCCCAGCTC
CCCATTCTGAAGCCCAGGTTCTACTCCATCAGCTCCTCCCGGGATCACACGCCCACGGAG
ATCCACCTGACTGTGGCCGTGGTCACCTACCACACCGGAGATGGCCAGGGTCCCCTGCAC
CACGGTGTCTGCAGCACATGGCTCAACAGCCTGAAGCCCCAAGACCCAGTGCCCTGCTTT
GTGCGGAATGCCAGCGCCTTCCACCTCCCCGAGGATCCCTCCCATCCTTGCATCCTCATC
GGGCCTGGCACAGGCATCGTGCCCTTCCGCAGTTTCTGGCAGCAACGGCTCCATGACTCC
CAGCACAAGGGAGTGCGGGGAGGCCGCATGACCTTGGTGTTTGGGTGCCGCCGCCCAGAT
GAGGACCACATCTACCAGGAGGAGATGCTGGAGATGGCCCAGAAGGGGGTGCTGCATGCG
GTGCACACAGCCTATTCCCGCCTGCCTGGCAAGCCCAAGGTCTATGTTCAGGACATCCTG
CGGCAGCAGCTGGCCAGCGAGGTGCTCCGTGTGCTCCACAAGGAGCCAGGCCACCTCTAT
GTTTGCGGGGATGTGCGCATGGCCCGGGACGTGGCCCACACCCTGAAGCAGCTGGTGGCT
GCCAAGCTGAAATTGAATGAGGAGCAGGTCGAGGACTATTTCTTTCAGCTCAAGAGCCAG
AAGCGCTATCACGAAGATATCTTCGGTGCTGTATTTCCTTACGAGGCGAAGAAGGACAGG
GTGGCGGTGCAGCCCAGCAGCCTGGAGATGTCAGCGCTCTGA

# Macromolecular_Interacting_Partner_17_GenBank_ID_Gene:
L09210

# Macromolecular_Interacting_Partner_17_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_17_Locus:
17q11.2-q12

# Macromolecular_Interacting_Partner_17_SNPs:
rs3730017; rs2297518; rs3729662; rs3730014; rs1137933; rs28999412; rs16966563; rs28730832; rs1060826; rs1060822; rs10459953; rs3730013; rs6505483; rs28998796; rs15782; rs28998799; rs3201742; rs28998798; rs2872753; rs944725; rs2314809; rs4795067; rs2297512; rs944724; rs9895831; rs3794763; rs3729966; rs4239250; rs8068149; rs3729508; rs4796052; rs944722; rs2297520; rs9904158; rs9797244; rs7208775; rs11080344; rs3729718; rs3794764; rs28450000; rs8080418; rs2297515; rs2297514; rs3730228; rs2297517; rs8065448; rs3794767; rs3794759; rs8070472; rs12452167; rs944723; rs17722851; rs3794756; rs4796040; rs2297511; rs3794765; rs4796034; rs8072199; rs10853180; rs2297510; rs3729507; rs16966545; rs2297513; rs8073631; rs9895453; rs17718148; rs2274894; rs7217335; rs3729719; rs2072324; rs2314812; rs3729720; rs3729727; rs2297516; rs8065817; rs3794766; rs8067880; rs3730234; rs9282801; rs9282800; rs3729661; rs4796080; rs2248814; rs6505445; rs9906835; rs9906122; rs28942375; rs11653716; rs3730232; rs1113283; rs28944194; rs28999408; rs3794761; rs8067177; rs28999370; rs41353546; rs28944186; rs2314813; rs11871315; rs28998815; rs6505469; rs28999387; rs28662210; rs28944196; rs28998832; rs28942968; rs28999414; rs28944190; rs28998809; rs28999393; rs28942373; rs16949; rs28944178; rs28999401; rs28998802; rs28999394; rs28944211; rs7213691; rs28998818; rs28998804; rs28944206; rs28998821; rs28944208; rs28998812; rs28944197; rs28999391; rs28999385; rs28944181; rs28999374; rs28998828; rs28999413; rs28999398; rs28998814; rs11870951; rs11871150; rs28998808; rs28944177; rs28998817; rs28999400; rs28944213; rs11657646; rs28999409; rs28942372; rs28999380; rs28998826; rs9890954; rs28942370; rs2255929; rs4796038; rs28944180; rs28998831; rs28944198; rs28999405; rs28942368; rs28944169; rs28999384; rs28944182; rs28999377; rs28998807; rs28998805; rs28944205; rs28998822; rs28999399; rs28944195; rs1962380; rs28944209; rs28944192; rs28999375; rs28944193; rs2314810; rs28999383; rs28999390; rs28999410; rs2779248; rs7406657; rs12450521; rs2779249; rs8081248; rs8078340; rs28943568; rs28944221; rs1800482; rs28998792; rs28944230; rs28998790; rs28944231; rs28944218; rs28973255; rs28944222; rs28944229; rs28944224; rs9282799; rs11080321; rs28998795; rs28944227; rs4795055; rs4796029; rs28944232; rs28944220; rs2314808; rs3730230; rs28944201; rs3729717; rs28944173; rs28999379; rs34719207; rs28944168; rs1137949; rs1060828; rs7223110; rs28944200; rs28944214; rs35834812; rs7359686; rs28998800; rs12453234; rs28944216; rs7359651; rs28998797; rs28944215; rs28944217; rs34749068; rs3794757; rs16948; rs34293265; rs28999411; rs41337547; rs28999396; rs28944202; rs34641676; rs3730231; rs28999403; rs7502274; rs4796055; rs10557822; rs28999368; rs9895077; rs34975273; rs28942378; rs28999407; rs28999372; rs3751971; rs9282802; rs28944171; rs34931287; rs35370851; rs28998816; rs28942369; rs28998825; rs28944184; rs28944212; rs11363739; rs28999404; rs34972969; rs28944176; rs28999376; rs28999415; rs28942379; rs28998811; rs11363740; rs28998827; rs41449853; rs28942376; rs35659482; rs3730015; rs28944185; rs28944188; rs28944191; rs28944172; rs28944174; rs10569534; rs28944179; rs28722995; rs3838879; rs28999371; rs28999389; rs28999382; rs28942374; rs28999397; rs34658875; rs7222398; rs28944170; rs28999416; rs3838880; rs28944183; rs28998824; rs4796041; rs41323846; rs28999386; rs28999378; rs28999406; rs34992777; rs28998829; rs28998833; rs3794760; rs28999373; rs35214201; rs28998810; rs3833855; rs28998806; rs28944189; rs34069634; rs28998803; rs28999369; rs28998830; rs41513847; rs28998823; rs12950084; rs28944199; rs28944203; rs35561933; rs11428460; rs34388532; rs5819821; rs35660190; rs35051118; rs28998813; rs35395276; rs28999392; rs28942377; rs34237194; rs28998801; rs3730016; rs28999395; rs28942371; rs3794758; rs11655101; rs28944210; rs28998819; rs34147660; rs28944175; rs28944207; rs10657353; rs28730831; rs3838881; rs28999388; rs28999402; rs28999381; rs28999417; rs28944187; rs34921306; rs3730229; rs28998820; rs28944223; rs28998794; rs35009352; rs28944228; rs34709845; rs28943570; rs28944226; rs1799765; rs28998793; rs28944233; rs28998791; rs28943569; rs28944225; rs28944219; rs12720460; rs28943571; rs34517795; rs11080358; rs12150211; rs12709500; rs16966425; rs2531860; rs2531861; rs2531862; rs2531863; rs2734299; rs2779251; rs2779252; rs2779253; rs2779254; rs2779255; rs4795050; rs4796018; rs4796028; rs7208420; rs7215373; rs8073782

# Macromolecular_Interacting_Partner_17_General_References:
7682706; 7692964; 7504305; 7522054; 7528017; 7531687; 7544004; 9160867; 7532248; 7558036; 9721329; 12080081; 10409685; 10074942

# Macromolecular_Interacting_Partner_17_References:
15087030; 16091294

# Macromolecular_Interacting_Partner_18_ID:
6263

# Macromolecular_Interacting_Partner_18_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_18_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_18_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_18_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_18_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_18_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_18_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_18_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_18_General_Function:
Not Available

# Macromolecular_Interacting_Partner_18_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_18_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_18_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_18_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_18_Signals:
1-17

# Macromolecular_Interacting_Partner_18_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_18_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_18_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_18_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_18_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_18_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_18_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_18_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_18_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_18_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_18_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_18_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_18_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_18_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_18_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_18_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_18_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_18_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_18_References:
12963019; 14596920; 14971826; 15063780

# Macromolecular_Interacting_Partner_19_ID:
7657

# Macromolecular_Interacting_Partner_19_Name:
Peroxisome proliferator-activated receptor gamma

# Macromolecular_Interacting_Partner_19_Synonyms:
PPAR-gamma

# Macromolecular_Interacting_Partner_19_Gene_Name:
PPARG

# Macromolecular_Interacting_Partner_19_Protein_Sequence:
>Peroxisome proliferatoractivated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY

# Macromolecular_Interacting_Partner_19_Number_of_Residues:
505

# Macromolecular_Interacting_Partner_19_Molecular_Weight:
57621

# Macromolecular_Interacting_Partner_19_Theoretical_pI:
5.77

# Macromolecular_Interacting_Partner_19_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_19_General_Function:
Not Available

# Macromolecular_Interacting_Partner_19_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis

# Macromolecular_Interacting_Partner_19_Pathway:
Not Available

# Macromolecular_Interacting_Partner_19_Reaction:
Not Available

# Macromolecular_Interacting_Partner_19_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_19_Signals:
None

# Macromolecular_Interacting_Partner_19_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_19_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_19_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_19_GenBank_ID_Protein:
1711117

# Macromolecular_Interacting_Partner_19_SwissProt_ID:
PPARG_HUMAN (P37231)

# Macromolecular_Interacting_Partner_19_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_19_Genecard_id:
PPARG

# Macromolecular_Interacting_Partner_19_Geneatlas_id:
PPARG

# Macromolecular_Interacting_Partner_19_hgnc_id:
HGNC:9236

# Macromolecular_Interacting_Partner_19_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_19_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_19_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_19_Gene_Sequence:
>1518 bp
ATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATACA
CTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCC
ACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT
GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC
ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAA
GAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT
CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT
GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAG
GGTTTCTTCCGGAGAACAATCAGATTGAAGCTTATCTATGACAGATGTGATCTTAACTGT
CGGATCCACAAAAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCA
GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAG
CTGTTGGCGGAGATCTCCAGTGATATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGG
GCCCTGGCAAAACATTTGTATGACTCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAG
GCGAGGGCGATCTTGACAGGAAAGACAACAGACAAATCACCATTCGTTATCTATGACATG
AATTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAACACATCACCCCCCTGCAGGAG
CAGAGCAAAGAGGTGGCCATCCGCATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCT
GTGCAGGAGATCACAGAGTATGCCAAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAAC
GACCAAGTAACTCTCCTCAAATATGGAGTCCACGAGATCATTTACACAATGCTGGCCTCC
TTGATGAATAAAGATGGGGTTCTCATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTT
CTAAAGAGCCTGCGAAAGCCTTTTGGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTG
AAGTTCAATGCACTGGAATTAGATGACAGCGACTTGGCAATATTTATTGCTGTCATTATT
CTCAGTGGAGACCGCCCAGGTTTGCTGAATGTGAAGCCCATTGAAGACATTCAAGACAAC
CTGCTACAAGCCCTGGAGCTCCAGCTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTT
GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTCACGGAACACGTGCAGCTA
CTGCAGGTGATCAAGAAGACGGAGACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATC
TACAAGGACTTGTACTAG

# Macromolecular_Interacting_Partner_19_GenBank_ID_Gene:
U79012

# Macromolecular_Interacting_Partner_19_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_19_Locus:
3p25

# Macromolecular_Interacting_Partner_19_SNPs:
rs1801282; rs3856806; rs4135352; rs13306747; rs1805151; rs2921188; rs2881654; rs6776454; rs12496005; rs2197423; rs4135307; rs4135315; rs4135316; rs880663; rs9829551; rs11128598; rs12636454; rs4135304; rs4135255; rs4135322; rs12631389; rs6800910; rs4135311; rs12487012; rs4135321; rs4135305; rs1064323; rs6800748; rs12496505; rs2120825; rs4135301; rs10510412; rs2028759; rs4135323; rs6802898; rs12629240; rs7647481; rs13095716; rs4135313; rs4684101; rs6805419; rs4135302; rs7627605; rs6809631; rs9310401; rs4135245; rs9817428; rs1899951; rs2938397; rs4135259; rs4135308; rs10865710; rs11715073; rs4684848; rs4135320; rs3885307; rs6778740; rs12629293; rs4135246; rs12636461; rs13433696; rs1373641; rs9812662; rs12639162; rs4135306; rs12633551; rs12497191; rs9858822; rs12629751; rs4135253; rs7648033; rs1596667; rs11128597; rs13083375; rs13070963; rs2007629; rs12630210; rs4135254; rs11128601; rs4135258; rs10510410; rs4135310; rs4145574; rs4135317; rs7646510; rs7636145; rs17036342; rs6768587; rs7620165; rs2012444; rs6798974; rs4135256; rs3892175; rs13073869; rs1122648; rs6782178; rs4145573; rs10510411; rs4135319; rs4135318; rs2938398; rs2972167; rs964232; rs4135247; rs2028760; rs17036328; rs10510418; rs9883281; rs11128603; rs4135312; rs6442311; rs12493718; rs9851767; rs2921189; rs11128599; rs17817276; rs6785890; rs13061415; rs2938396; rs4135248; rs4135257; rs4135303; rs6442310; rs12485478; rs7638903; rs7617488; rs28763893; rs4135250; rs17793693; rs12490265; rs17036326; rs7646425; rs4135249; rs2972164; rs1373640; rs17036263; rs4135251; rs4135314; rs12631819; rs11710969; rs7638788; rs17036321; rs11128596; rs4135309; rs12639094; rs17036188; rs6795085; rs12629497; rs3112395; rs6808179; rs2920505; rs12631028; rs6795946; rs13064760; rs6809832; rs35206526; rs7649970; rs17036314; rs11128600; rs4684845; rs10865711; rs12631322; rs7615916; rs9882725; rs9849386; rs2067819; rs11716748; rs17817469; rs17029006; rs4684846; rs2881479; rs17036242; rs6788489; rs11719186; rs6792284; rs4073770; rs12634544; rs2972168; rs2921190; rs9842021; rs13306745; rs11715016; rs11128602; rs13076055; rs12496413; rs7610055; rs9823137; rs9883193; rs17435731; rs2346795; rs4362702; rs10510417; rs6768049; rs12330440; rs12495364; rs9814788; rs17029008; rs2067820; rs6766920; rs11709077; rs2960422; rs17425935; rs17036163; rs17036281; rs17036160; rs6801982; rs4518111; rs17050719; rs3112393; rs4684847; rs17036174; rs17036282; rs10212597; rs34359034; rs17036165; rs35080475; rs17036333; rs17793951; rs1984669; rs17036170; rs12486170; rs9876942; rs12635309; rs4315668; rs11718775; rs9870196; rs3963364; rs1373642; rs1822825; rs2959273; rs2938394; rs2938392; rs1151998; rs709149; rs796313; rs709156; rs1175543; rs1175540; rs2959272; rs2972162; rs1875796; rs1151996; rs1151997; rs1797912; rs709154; rs796290; rs4135359; rs4135343; rs4135260; rs4135354; rs1152002; rs4135293; rs709157; rs4135327; rs709148; rs4135358; rs709152; rs4135329; rs4135344; rs2938395; rs4135263; rs4135330; rs1177809; rs4135345; rs4135296; rs4135264; rs1151999; rs2655259; rs4135324; rs4135332; rs4135276; rs709147; rs4135356; rs709151; rs4135362; rs6442313; rs709158; rs4135282; rs4135333; rs6442312; rs4135281; rs1175541; rs1175542; rs4135340; rs4135277; rs4135350; rs2938387; rs4135266; rs4135288; rs7626560; rs4135341; rs2921193; rs4135285; rs4135361; rs4135348; rs4135326; rs2938389; rs4135347; rs4135351; rs4135261; rs2972163; rs4135337; rs4135292; rs4135286; rs709155; rs2938388; rs10510420; rs4135299; rs4135283; rs2959271; rs4135273; rs4135294; rs7645903; rs4135284; rs4135335; rs4135280; rs709150; rs4135274; rs4135357; rs4135289; rs6794024; rs709153; rs4135331; rs1152001; rs7650895; rs4135336; rs1699337; rs2959269; rs4135346; rs4135265; rs4135275; rs4135278; rs4135297; rs6782475; rs4135295; rs4135355; rs10510419; rs4135334; rs4135338; rs4135290; rs2959268; rs4135360; rs4135298; rs2292101; rs4135349; rs4135287; rs895095; rs4135267; rs4135339; rs7634282; rs4135353; rs12489347; rs17036700; rs4135262; rs1175544; rs4135291; rs4135270; rs4135268; rs4135342; rs4135328; rs4135279; rs4135325; rs4135269; rs35724001; rs7639159; rs7636854; rs3105363; rs13099828; rs13099634; rs34611445; rs7636421; rs7636598; rs7616804; rs11293844; rs7639005; rs13099078; rs35125975; rs11128604; rs2307991; rs35812816; rs9282832; rs36073622; rs7623946; rs9871668; rs12632365; rs4684103; rs35995141; rs7635807; rs6784211; rs9836965; rs35520264; rs9876829; rs4135364; rs13077495; rs13076933; rs17029002; rs4135363; rs4135300; rs17425960; rs34577159; rs9880344; rs17028996; rs35138542; rs9714363; rs35204164; rs2920502; rs28936407; rs1805192; rs1800571; rs41516544; rs28763894; rs13306746; rs41415646; rs34462475; rs34797620; rs13085211; rs35324344; rs28675782; rs34047730; rs9812856; rs34861493; rs11558404; rs34251960; rs35459073; rs2972165; rs13316783; rs34091265; rs34108955; rs2347528; rs6802327; rs35658489; rs34391565; rs34034515; rs11718894; rs34727071; rs33992296; rs2921186; rs13067060; rs2197424; rs3031383; rs28469357; rs9812859; rs35649998; rs35590426; rs13090995; rs17036428; rs17029009; rs34665399; rs34694812; rs11323214; rs5846770; rs13088728; rs35004171; rs17036277; rs9860894; rs11712531; rs34096560; rs13097936; rs13082177; rs35917766; rs36001830; rs28684849; rs17425942; rs34598704; rs17036279; rs3910864; rs34915207; rs11319327; rs35408322; rs28435743; rs2972160; rs11921075; rs13095372; rs3112394; rs4438634; rs36035284; rs11450436; rs2921187; rs34758352; rs13091468; rs10620909; rs11360916; rs10665975; rs7614873; rs17029007; rs9858703; rs11321700; rs34832349; rs35958630; rs36009235; rs11712037; rs35256588; rs35816057; rs17050720; rs10212146; rs35562755; rs10212145; rs34295844; rs7650213; rs3112392; rs35763971; rs11719187; rs35248164; rs34914033; rs7627000; rs2972161; rs9282833; rs7430836; rs11718489; rs17036183; rs13082084; rs35305483; rs35986947; rs35944176; rs2972159; rs5846769; rs17036317; rs9813120; rs11293858; rs35196430; rs9824047; rs11458097; rs11394520; rs34762200; rs2920501; rs35224214; rs34258522; rs35431607; rs35830690; rs1064061; rs7641290; rs5846771; rs35240997; rs35824198; rs1984668; rs3963365; rs11712510; rs34850546; rs28783437; rs28683092; rs34001022; rs2920504; rs10619114; rs35788455; rs17036179; rs9827378; rs35586299; rs35112713; rs11456875; rs35000407; rs6787534; rs12106668; rs13091131; rs34856298; rs34132377; rs13095882; rs6795126; rs2938393; rs35403303; rs11373145; rs36052770; rs13316883; rs10587216; rs3773360; rs7612778; rs11451254; rs35474352; rs4371498; rs11324808; rs35789821; rs9837762; rs11372505; rs13071893; rs2921192; rs35942115; rs11287877; rs1152000; rs11280439; rs11337165; rs35434486; rs1797879; rs11346922; rs35190152; rs41311317; rs10540594; rs35649722; rs10049123; rs34692304; rs1699373; rs10602525; rs34493672; rs34334895; rs3821614; rs9837916; rs1797878; rs12629147; rs9843706; rs13064303; rs35491663; rs35258697; rs10643169; rs4684852; rs2938391; rs35632413; rs35218291; rs3127609; rs5846772; rs3105364; rs13095707; rs34897095; rs2938390; rs35121790; rs6147711; rs13075164; rs4684851; rs34151900; rs35880011; rs9833647; rs10614129; rs1987536; rs11427297; rs35082382; rs36025945; rs13095719; rs36121170; rs3836371; rs34898812; rs34318338; rs11914306; rs3127608; rs35948804; rs11344254; rs796289; rs11377897; rs35598149; rs10575755; rs36055981; rs11368226; rs11713869; rs10048953; rs11446342; rs1797895; rs35691895; rs41484149; rs1185785; rs11329101; rs3773357; rs3210577; rs41293379; rs28848197; rs34241217; rs7627540; rs3103310; rs4684102; rs35168570; rs41491647; rs10222537; rs1152003; rs1152004; rs1152005; rs1175545; rs1181795; rs13066537; rs13090265; rs1663813; rs17036753; rs1797877; rs2920500; rs2920503; rs2960421; rs4498025; rs4684104; rs6790976; rs709159; rs7609637; rs7616847; rs7622847; rs7643499; rs9827787; rs9831245; rs9831411; rs9833097; rs9837686; rs9868474

# Macromolecular_Interacting_Partner_19_General_References:
9065481; 8702406; 9144532; 7787419; 9356045; 8706692; 10681503; 11971969; 10882139; 9425261; 9753710; 10407229; 10394368; 10622252; 11788685

# Macromolecular_Interacting_Partner_19_References:
14739357; 16112107; 16927016

# Macromolecular_Interacting_Partner_20_ID:
7659

# Macromolecular_Interacting_Partner_20_Name:
Cyclin-dependent kinase inhibitor 1

# Macromolecular_Interacting_Partner_20_Synonyms:
p21; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6

# Macromolecular_Interacting_Partner_20_Gene_Name:
CDKN1A

# Macromolecular_Interacting_Partner_20_Protein_Sequence:
>Cyclindependent kinase inhibitor 1
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE
GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV
PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

# Macromolecular_Interacting_Partner_20_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_20_Molecular_Weight:
18120

# Macromolecular_Interacting_Partner_20_Theoretical_pI:
8.50

# Macromolecular_Interacting_Partner_20_GO_Classification:
>>>
Function:  enzyme regulator activity
Function:  enzyme inhibitor activity
Function:  kinase inhibitor activity
Function:  protein kinase inhibitor activity
Function:  cyclin-dependent protein kinase inhibitor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of cell cycle
Process:  regulation of progression through cell cycle
Process:  negative regulation of progression through cell cycle
Process:  cell cycle arrest
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_20_General_Function:
Not Available

# Macromolecular_Interacting_Partner_20_Specific_Function:
May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression

# Macromolecular_Interacting_Partner_20_Pathway:
Not Available

# Macromolecular_Interacting_Partner_20_Reaction:
Not Available

# Macromolecular_Interacting_Partner_20_Pfam_Domain_Function:
PF02234:CDI

# Macromolecular_Interacting_Partner_20_Signals:
None

# Macromolecular_Interacting_Partner_20_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_20_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_20_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_20_GenBank_ID_Protein:
425143

# Macromolecular_Interacting_Partner_20_SwissProt_ID:
CDN1A_HUMAN (P38936)

# Macromolecular_Interacting_Partner_20_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_20_Genecard_id:
CDKN1A

# Macromolecular_Interacting_Partner_20_Geneatlas_id:
CDKN1A

# Macromolecular_Interacting_Partner_20_hgnc_id:
HGNC:1784

# Macromolecular_Interacting_Partner_20_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_20_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_20_Subcellular_Location:
Cytoplasm. Nucleus

# Macromolecular_Interacting_Partner_20_Gene_Sequence:
>495 bp
ATGTCAGAACCGGCTGGGGATGTCCGTCAGAACCCATGCGGCAGCAAGGCCTGCCGCCGC
CTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGACTGTGATGCGCTAATGGCGGGC
TGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGACTTTGTCACCGAGACACCACTGGAG
GGTGACTTCGCCTGGGAGCGTGTGCGGGGCCTTGGCCTGCCCAAGCTCTACCTTCCCACG
GGGCCCCGGCGAGGCCGGGATGAGTTGGGAGGAGGCAGGCGGCCTGGCACCTCACCTGCT
CTGCTGCAGGGGACAGCAGAGGAAGACCATGTGGACCTGTCACTGTCTTGTACCCTTGTG
CCTCGCTCAGGGGAGCAGGCTGAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCGA
AAACGGCGGCAGACCAGCATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCC
AAGAGGAAGCCCTAA

# Macromolecular_Interacting_Partner_20_GenBank_ID_Gene:
L25610

# Macromolecular_Interacting_Partner_20_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_20_Locus:
6p21.2

# Macromolecular_Interacting_Partner_20_SNPs:
Not Available

# Macromolecular_Interacting_Partner_20_General_References:
8242751; 8242752; 8259214; 8125163; 7655464; 14574404; 10753973; 11463845; 8861913

# Macromolecular_Interacting_Partner_20_References:
12806965; 14559818; 14690797; 14750171

# Macromolecular_Interacting_Partner_21_ID:
7661

# Macromolecular_Interacting_Partner_21_Name:
Thrombopoietin precursor

# Macromolecular_Interacting_Partner_21_Synonyms:
Megakaryocyte colony-stimulating factor; Myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; ML; Megakaryocyte growth and development factor; MGDF

# Macromolecular_Interacting_Partner_21_Gene_Name:
THPO

# Macromolecular_Interacting_Partner_21_Protein_Sequence:
>Thrombopoietin precursor
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG

# Macromolecular_Interacting_Partner_21_Number_of_Residues:
353

# Macromolecular_Interacting_Partner_21_Molecular_Weight:
37823

# Macromolecular_Interacting_Partner_21_Theoretical_pI:
9.86

# Macromolecular_Interacting_Partner_21_GO_Classification:
>>>
Function:  cytokine activity
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell proliferation
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_21_General_Function:
Not Available

# Macromolecular_Interacting_Partner_21_Specific_Function:
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets

# Macromolecular_Interacting_Partner_21_Pathway:
Not Available

# Macromolecular_Interacting_Partner_21_Reaction:
Not Available

# Macromolecular_Interacting_Partner_21_Pfam_Domain_Function:
PF00758:EPO_TPO

# Macromolecular_Interacting_Partner_21_Signals:
1-21

# Macromolecular_Interacting_Partner_21_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_21_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_21_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_21_GenBank_ID_Protein:
506827

# Macromolecular_Interacting_Partner_21_SwissProt_ID:
TPO_HUMAN (P40225)

# Macromolecular_Interacting_Partner_21_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_21_Genecard_id:
THPO

# Macromolecular_Interacting_Partner_21_Geneatlas_id:
THPO

# Macromolecular_Interacting_Partner_21_hgnc_id:
HGNC:11795

# Macromolecular_Interacting_Partner_21_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_21_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_21_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_21_Gene_Sequence:
>1062 bp
ATGGAGCTGACTGAATTGCTCCTCGTGGTCATGCTTCTCCTAACTGCAAGGCTAACGCTG
TCCAGCCCGGCTCCTCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC
CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTC
CTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAG
GCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGA
CAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTC
CTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACA
GCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTG
CGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGCGGGCCCCACCCACCACA
GCTGTCCCCAGCAGAACCTCTCTAGTCCTCACACTGAACGAGCTCCCAAACAGGACTTCT
GGATTGTTGGAGACAAACTTCACTGCCTCAGCCAGAACTACTGGCTCTGGGCTTCTGAAG
TGGCAGCAGGGATTCAGAGCCAAGATTCCTGGTCTGCTGAACCAAACCTCCAGGTCCCTG
GACCAAATCCCCGGATACCTGAACAGGATACACGAACTCTTGAATGGAACTCGTGGACTC
TTTCCTGGACCCTCACGCAGGACCCTAGGAGCCCCGGACATTTCCTCAGGAACATCAGAC
ACAGGCTCCCTGCCACCCAACCTCCAGCCTGGATATTCTCCTTCCCCAACCCATCCTCCT
ACTGGACAGTATACGCTCTTCCCTCTTCCACCCACCTTGCCCACCCCTGTGGTCCAGCTC
CACCCCCTGCTTCCTGACCCTTCTGCTCCAACGCCCACCCCTACCAGCCCTCTTCTAAAC
ACATCCTACACCCACTCCCAGAATCTGTCTCAGGAAGGGTAA

# Macromolecular_Interacting_Partner_21_GenBank_ID_Gene:
L33410

# Macromolecular_Interacting_Partner_21_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_21_Locus:
3q27

# Macromolecular_Interacting_Partner_21_SNPs:
rs956732; rs6141; rs13084750; rs3792299; rs3804618; rs2280740; rs10513797; rs6142; rs16858759; rs13091574; rs952982; rs1126665; rs1042346; rs1126664; rs35794435; rs1042348; rs35796121; rs13084357; rs2700319; rs34623301; rs2700322; rs2700320; rs34037653; rs2464115; rs10702924; rs9870912; rs36062626; rs28550009; rs13094594; rs16858778; rs16858780; rs1802869; rs2239856; rs2855306; rs34052076; rs34147749; rs35087408; rs35633216; rs35929225; rs3749228; rs3749229; rs4912484; rs4912485; rs4912486; rs4912487; rs7615189; rs885838

# Macromolecular_Interacting_Partner_21_General_References:
8202154; 8020099; 7809166; 7926023; 7849319; 8537317; 7822271

# Macromolecular_Interacting_Partner_21_References:
15903240; 16169764

# Macromolecular_Interacting_Partner_22_ID:
7666

# Macromolecular_Interacting_Partner_22_Name:
Signal transducer and activator of transcription 1-alpha/beta

# Macromolecular_Interacting_Partner_22_Synonyms:
Transcription factor ISGF-3 components p91/p84

# Macromolecular_Interacting_Partner_22_Gene_Name:
STAT1

# Macromolecular_Interacting_Partner_22_Protein_Sequence:
>Signal transducer and activator of transcription 1alpha/beta
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV

# Macromolecular_Interacting_Partner_22_Number_of_Residues:
750

# Macromolecular_Interacting_Partner_22_Molecular_Weight:
87336

# Macromolecular_Interacting_Partner_22_Theoretical_pI:
5.92

# Macromolecular_Interacting_Partner_22_GO_Classification:
>>>
Function:  signal transducer activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_22_General_Function:
Not Available

# Macromolecular_Interacting_Partner_22_Specific_Function:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state

# Macromolecular_Interacting_Partner_22_Pathway:
Not Available

# Macromolecular_Interacting_Partner_22_Reaction:
Not Available

# Macromolecular_Interacting_Partner_22_Pfam_Domain_Function:
PF00017:SH2;
PF01017:STAT_alpha;
PF02864:STAT_bind;
PF02865:STAT_int

# Macromolecular_Interacting_Partner_22_Signals:
None

# Macromolecular_Interacting_Partner_22_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_22_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_22_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_22_GenBank_ID_Protein:
2281071

# Macromolecular_Interacting_Partner_22_SwissProt_ID:
STAT1_HUMAN (P42224)

# Macromolecular_Interacting_Partner_22_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_22_Genecard_id:
STAT1

# Macromolecular_Interacting_Partner_22_Geneatlas_id:
STAT1

# Macromolecular_Interacting_Partner_22_hgnc_id:
HGNC:11362

# Macromolecular_Interacting_Partner_22_PDB_ID:
1YVL

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_22_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_22_Subcellular_Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta

# Macromolecular_Interacting_Partner_22_Gene_Sequence:
>2253 bp
ATGTCTCAGTGGTACGAACTTCAGCAGCTTGACTCAAAATTCCTGGAGCAGGTTCACCAG
CTTTATGATGACAGTTTTCCCATGGAAATCAGACAGTACCTGGCACAGTGGTTAGAAAAG
CAAGACTGGGAGCACGCTGCCAATGATGTTTCATTTGCCACCATCCGTTTTCATGACCTC
CTGTCACAGCTGGATGATCAATATAGTCGCTTTTCTTTGGAGAATAACTTCTTGCTACAG
CATAACATAAGGAAAAGCAAGCGTAATCTTCAGGATAATTTTCAGGAAGACCCAATCCAG
ATGTCTATGATCATTTACAGCTGTCTGAAGGAAGAAAGGAAAATTCTGGAAAACGCCCAG
AGATTTAATCAGGCTCAGTCGGGGAATATTCAGAGCACAGTGATGTTAGACAAACAGAAA
GAGCTTGACAGTAAAGTCAGAAATGTGAAGGACAAGGTTATGTGTATAGAGCATGAAATC
AAGAGCCTGGAAGATTTACAAGATGAATATGACTTCAAATGCAAAACCTTGCAGAACAGA
GAACACGAGACCAATGGTGTGGCAAAGAGTGATCAGAAACAAGAACAGCTGTTACTCAAG
AAGATGTATTTAATGCTTGACAATAAGAGAAAGGAAGTAGTTCACAAAATAATAGAGTTG
CTGAATGTCACTGAACTTACCCAGAATGCCCTGATTAATGATGAACTAGTGGAGTGGAAG
CGGAGACAGCAGAGCGCCTGTATTGGGGGGCCGCCCAATGCTTGCTTGGATCAGCTGCAG
AACTGGTTCACTATAGTTGCGGAGAGTCTGCAGCAAGTTCGGCAGCAGCTTAAAAAGTTG
GAGGAATTGGAACAGAAATACACCTACGAACATGACCCTATCACAAAAAACAAACAAGTG
TTATGGGACCGCACCTTCAGTCTTTTCCAGCAGCTCATTCAGAGCTCGTTTGTGGTGGAA
AGACAGCCCTGCATGCCAACGCACCCTCAGAGGCCGCTGGTCTTGAAGACAGGGGTCCAG
TTCACTGTGAAGTTGAGACTGTTGGTGAAATTGCAAGAGCTGAATTATAATTTGAAAGTC
AAAGTCTTATTTGATAAAGATGTGAATGAGAGAAATACAGTAAAAGGATTTAGGAAGTTC
AACATTTTGGGCACGCACACAAAAGTGATGAACATGGAGGAGTCCACCAATGGCAGTCTG
GCGGCTGAATTTCGGCACCTGCAATTGAAAGAACAGAAAAATGCTGGCACCAGAACGAAT
GAGGGTCCTCTCATCGTTACTGAAGAGCTTCACTCCCTTAGTTTTGAAACCCAATTGTGC
CAGCCTGGTTTGGTAATTGACCTCGAGACGACCTCTCTGCCCGTTGTGGTGATCTCCAAC
GTCAGCCAGCTCCCGAGCGGTTGGGCCTCCATCCTTTGGTACAACATGCTGGTGGCGGAA
CCCAGGAATCTGTCCTTCTTCCTGACTCCACCATGTGCACGATGGGCTCAGCTTTCAGAA
GTGCTGAGTTGGCAGTTTTCTTCTGTCACCAAAAGAGGTCTCAATGTGGACCAGCTGAAC
ATGTTGGGAGAGAAGCTTCTTGGTCCTAACGCCAGCCCCGATGGTCTCATTCCGTGGACG
AGGTTTTGTAAGGAAAATATAAATGATAAAAATTTTCCCTTCTGGCTTTGGATTGAAAGC
ATCCTAGAACTCATTAAAAAACACCTGCTCCCTCTCTGGAATGATGGGTGCATCATGGGC
TTCATCAGCAAGGAGCGAGAGCGTGCCCTGTTGAAGGACCAGCAGCCGGGGACCTTCCTG
CTGCGGTTCAGTGAGAGCTCCCGGGAAGGGGCCATCACATTCACATGGGTGGAGCGGTCC
CAGAACGGAGGCGAACCTGACTTCCATGCGGTTGAACCCTACACGAAGAAAGAACTTTCT
GCTGTTACTTTCCCTGACATCATTCGCAATTACAAAGTCATGGCTGCTGAGAATATTCCT
GAGAATCCCCTGAAGTATCTGTATCCAAATATTGACAAAGACCATGCCTTTGGAAAGTAT
TACTCCAGGCCAAAGGAAGCACCAGAGCCAATGGAACTTGATGGCCCTAAAGGAACTGGA
TATATCAAGACTGAGTTGATTTCTGTGTCTGAAGTTCACCCTTCTAGACTTCAGACCACA
GACAACCTGCTCCCCATGTCTCCTGAGGAGTTTGACGAGGTGTCTCGGATAGTGGGCTCT
GTAGAATTCGACAGTATGATGAACACAGTATAG

# Macromolecular_Interacting_Partner_22_GenBank_ID_Gene:
M97935

# Macromolecular_Interacting_Partner_22_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_22_Locus:
2q32.2

# Macromolecular_Interacting_Partner_22_SNPs:
rs34255470; rs2066802; rs13029532; rs36077929; rs11305; rs16833172; rs6745710; rs2066798; rs2030171; rs908598; rs2066804; rs1914408; rs4853536; rs1547550; rs12693590; rs7597768; rs10173099; rs13010343; rs7562024; rs4853535; rs10199181; rs13395505; rs2280232; rs2066805; rs6718902; rs2280235; rs12693591; rs41495745; rs41388645; rs2280234; rs16833155; rs11887394; rs11885069; rs11887698; rs41511150; rs41514544; rs41427447; rs16833157; rs41430444; rs4327257; rs3755312; rs16833143; rs13012785; rs17817076; rs41366946; rs11677408; rs11693463; rs9789700; rs3771300; rs3755311; rs2066795; rs1033248; rs11904548; rs2280233; rs16833141; rs10167514; rs2066797; rs6734110; rs2066799; rs2066806; rs2066794; rs16833144; rs41440051; rs10183196; rs16824035; rs13390894; rs12464143; rs9789428; rs11688154; rs4853533; rs16833160; rs41514553; rs16833147; rs2066800; rs4853537; rs13029247; rs17749316; rs12475993; rs4853532; rs13005843; rs7575823; rs34997637; rs7565237; rs16833164; rs10179199; rs6711082; rs2066793; rs16833142; rs11679212; rs41375144; rs2066803; rs7576984; rs7562400; rs2066801; rs16833146; rs10190333; rs11894425; rs1400657; rs12468579; rs1467198; rs12693589; rs4853455; rs11678454; rs17817900; rs12693588; rs1467199; rs10195683; rs36234015; rs10208033; rs36234022; rs11689880; rs11682932; rs16833126; rs11549696; rs41473544; rs1803838; rs41509946; rs35364817; rs35098579; rs41270237; rs41324145; rs41476445; rs41363648; rs34099150; rs3215260; rs5837214; rs35110557; rs41481847; rs34979992; rs34692732; rs3215258; rs11549697; rs11549698; rs41330944; rs41390345; rs11315624; rs41499444; rs35796119; rs41531551; rs4306740; rs4853538; rs41378045; rs41350748; rs41453045; rs41413547; rs41381545; rs41429347; rs41379748; rs41446247; rs34321682; rs7422639; rs41450049; rs41384345; rs41339847; rs11386507; rs41507345; rs41454144; rs41429349; rs41384750; rs41333947; rs2066796; rs41457547; rs41474144; rs7577007; rs13027303; rs41427344; rs36021646; rs12477076; rs35908641; rs41383548; rs41392944; rs41359252; rs41417844; rs41411149; rs41508653; rs41373544; rs41464253; rs5837215; rs41364950; rs41504347; rs1914407; rs41505447; rs41330646; rs7355231; rs34287013; rs41438845; rs41454245; rs41348952; rs41411249; rs41463952; rs41449550; rs41488044; rs7589233; rs3830526; rs34589515; rs41499349; rs10635466; rs35378485; rs34975356; rs41470846; rs41504449; rs41515945; rs4853534; rs41379347; rs35046975; rs41523450; rs41402551; rs36014758; rs34230248; rs34723079; rs13410645; rs11546470; rs41533248; rs35635960; rs10183400; rs41497045; rs34465916; rs41379447; rs36116009; rs35669756; rs5837216; rs35789081; rs35284787; rs35178261; rs35085810; rs35192272; rs41497448; rs952798; rs10166027; rs41484944; rs41421850; rs41411845; rs34945497; rs41371944; rs13027915; rs36234021; rs41325845; rs13027923; rs10174720; rs36234019; rs41385444; rs41452847; rs41457850; rs34480951; rs10437; rs1168; rs11690599; rs11692579; rs11884122; rs11885168; rs11899865; rs12469810; rs12987796; rs13000734; rs13020076; rs13035504; rs1400658; rs1546646; rs16833113; rs16833123; rs16833177; rs17748980; rs17817966; rs3088307; rs35890674; rs6712504; rs6751855; rs6752638; rs7558921; rs867637; rs883844

# Macromolecular_Interacting_Partner_22_General_References:
1502203; 7885841; 7657660; 7543024; 11442634; 10702714; 9630226

# Macromolecular_Interacting_Partner_22_References:
14517348

# Macromolecular_Interacting_Partner_23_ID:
7434

# Macromolecular_Interacting_Partner_23_Name:
Caspase-3 precursor

# Macromolecular_Interacting_Partner_23_Synonyms:
CASP-3; Apopain; Cysteine protease CPP32; Yama protein; CPP-32; SREBP cleavage activity 1; SCA-1[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]

# Macromolecular_Interacting_Partner_23_Gene_Name:
CASP3

# Macromolecular_Interacting_Partner_23_Protein_Sequence:
>Caspase3 precursor
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

# Macromolecular_Interacting_Partner_23_Number_of_Residues:
277

# Macromolecular_Interacting_Partner_23_Molecular_Weight:
31608

# Macromolecular_Interacting_Partner_23_Theoretical_pI:
6.51

# Macromolecular_Interacting_Partner_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  cysteine-type endopeptidase activity
Function:  caspase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_23_General_Function:
Not Available

# Macromolecular_Interacting_Partner_23_Specific_Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin

# Macromolecular_Interacting_Partner_23_Pathway:
Not Available

# Macromolecular_Interacting_Partner_23_Reaction:
Not Available

# Macromolecular_Interacting_Partner_23_Pfam_Domain_Function:
PF00656:Peptidase_C14

# Macromolecular_Interacting_Partner_23_Signals:
None

# Macromolecular_Interacting_Partner_23_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_23_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_23_EC_Link:
EC 3.4.22.56

# Macromolecular_Interacting_Partner_23_GenBank_ID_Protein:
561666

# Macromolecular_Interacting_Partner_23_SwissProt_ID:
CASP3_HUMAN (P42574)

# Macromolecular_Interacting_Partner_23_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_23_Genecard_id:
CASP3

# Macromolecular_Interacting_Partner_23_Geneatlas_id:
CASP3

# Macromolecular_Interacting_Partner_23_hgnc_id:
HGNC:1504

# Macromolecular_Interacting_Partner_23_PDB_ID:
1CP3

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_23_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_23_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_23_Gene_Sequence:
>834 bp
ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC
ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT
TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA
ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC
TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG
CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC
CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA
AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT
CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT
GACATGGCGTGTCATAAAATACCAGTGGATGCCGACTTCTTGTATGCATACTCCACAGCA
CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT
GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC
CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA
CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA

# Macromolecular_Interacting_Partner_23_GenBank_ID_Gene:
U13737

# Macromolecular_Interacting_Partner_23_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_23_Locus:
4q34

# Macromolecular_Interacting_Partner_23_SNPs:
rs35578277; rs1049210; rs35566035; rs1049253; rs2720378; rs3087455; rs6948; rs4647640; rs4647610; rs4647617; rs4647642; rs4647634; rs4647611; rs4647620; rs1049216; rs4647641; rs4647618; rs4647609; rs4647694; rs8549; rs4647698; rs4647614; rs4647621; rs4647622; rs4647616; rs4647633; rs4647643; rs4647630; rs34184817; rs4647647; rs35422505; rs4647624; rs4647626; rs4647696; rs4647606; rs4647631; rs4647646; rs4647607; rs4647625; rs34022730; rs35439719; rs2720377; rs4647632; rs4647628; rs2310103; rs34309992; rs4647629; rs4647644; rs4647636; rs2019978; rs2705891; rs1830254; rs2720376; rs2696056; rs4241793; rs4647667; rs4647688; rs4647663; rs1405942; rs4647652; rs1405938; rs4647662; rs2705901; rs1405944; rs4647671; rs4647665; rs2696057; rs4647693; rs4647672; rs2705897; rs4647669; rs4647673; rs4647692; rs4647674; rs4647666; rs4647686; rs4647683; rs4647690; rs4647657; rs4987118; rs4647679; rs4647670; rs4987119; rs4647658; rs4647684; rs4647675; rs4647650; rs34319440; rs4647685; rs2696048; rs4647651; rs4647676; rs4647687; rs4647655; rs13128316; rs13435139; rs4647704; rs4647700; rs12646257; rs4647701; rs4647623; rs4647635; rs10028033; rs12641602; rs13101834; rs11380373; rs4647695; rs34119644; rs2705892; rs34858791; rs35063555; rs4647699; rs4647639; rs34095700; rs4647619; rs13102911; rs4647645; rs4647612; rs13101835; rs4647637; rs4647638; rs2705893; rs4647649; rs2696060; rs10028034; rs4647697; rs4647613; rs35978407; rs4647608; rs4647615; rs28418774; rs4647648; rs1802667; rs34568867; rs7442206; rs4647682; rs4647656; rs4647681; rs4647668; rs4647677; rs4647678; rs4647691; rs35261594; rs4647689; rs4647653; rs35966919; rs34740772; rs4647659; rs41314884; rs9997231; rs3215361; rs4647661; rs4647654; rs10014306; rs10660141; rs4647664; rs4647660; rs4647680; rs10034836; rs35094553; rs9715122; rs4647705; rs34083547; rs9715863; rs4647702; rs4647703; rs11930666; rs12108497; rs12507711; rs13108061; rs13435890; rs1405937; rs2696058; rs2696059; rs2705881; rs2705882; rs2705900; rs2720388; rs2720389; rs34605630; rs4647600; rs4647602; rs4647603; rs4647605; rs4861629; rs4862396; rs4862399; rs7673753; rs7674164; rs7687648; rs9685847

# Macromolecular_Interacting_Partner_23_General_References:
7983002; 7774019; 7596430; 8673606; 9045680; 10821855; 8755496; 8696339

# Macromolecular_Interacting_Partner_23_References:
12618885; 15504750; 15528887; 15583047

# Macromolecular_Interacting_Partner_24_ID:
6829

# Macromolecular_Interacting_Partner_24_Name:
Mitogen-activated protein kinase 10

# Macromolecular_Interacting_Partner_24_Synonyms:
Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12

# Macromolecular_Interacting_Partner_24_Gene_Name:
MAPK10

# Macromolecular_Interacting_Partner_24_Protein_Sequence:
>Mitogenactivated protein kinase 10
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

# Macromolecular_Interacting_Partner_24_Number_of_Residues:
464

# Macromolecular_Interacting_Partner_24_Molecular_Weight:
52586

# Macromolecular_Interacting_Partner_24_Theoretical_pI:
6.78

# Macromolecular_Interacting_Partner_24_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein serine/threonine kinase activity
Function:  receptor signaling protein serine/threonine kinase activity
Function:  MAP kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_24_General_Function:
Not Available

# Macromolecular_Interacting_Partner_24_Specific_Function:
Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

# Macromolecular_Interacting_Partner_24_Pathway:
Not Available

# Macromolecular_Interacting_Partner_24_Reaction:
Not Available

# Macromolecular_Interacting_Partner_24_Pfam_Domain_Function:
PF00069:Pkinase

# Macromolecular_Interacting_Partner_24_Signals:
None

# Macromolecular_Interacting_Partner_24_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_24_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_24_EC_Link:
EC 2.7.11.24

# Macromolecular_Interacting_Partner_24_GenBank_ID_Protein:
468151

# Macromolecular_Interacting_Partner_24_SwissProt_ID:
MK10_HUMAN (P53779)

# Macromolecular_Interacting_Partner_24_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_24_Genecard_id:
MAPK10

# Macromolecular_Interacting_Partner_24_Geneatlas_id:
MAPK10

# Macromolecular_Interacting_Partner_24_hgnc_id:
HGNC:6872

# Macromolecular_Interacting_Partner_24_PDB_ID:
1JNK

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_24_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_24_Subcellular_Location:
Cytoplasm

# Macromolecular_Interacting_Partner_24_Gene_Sequence:
>1269 bp
ATGAGCCTCCATTTCTTATACTACTGCAGTGAACCAACATTGGATGTGAAAATTGCCTTT
TGTCAGGGATTCGATAAACAAGTGGATGTGTCATATATTGCCAAACATTACAACATGAGC
AAAAGCAAAGTTGACAACCAGTTCTACAGTGTGGAAGTGGGAGACTCAACCTTCACAGTT
CTCAAGCGCTACCAGAATCTAAAGCCTATTGGCTCTGGGGCTCAGGGCATAGTTTGTGCC
GCGTATGATGCTGTCCTTGACAGAAATGTGGCCATTAAGAAGCTCAGCAGACCCTTTCAG
AACCAAACACATGCCAAGAGAGCGTACCGGGAGCTGGTCCTCATGAAGTGTGTGAACCAT
AAAAACATTATTAGTTTATTAAATGTCTTCACACCCCAGAAAACGCTGGAGGAGTTCCAA
GATGTTTACTTAGTAATGGAACTGATGGATGCCAACTTATGTCAAGTGATTCAGATGGAA
TTAGACCATGAGCGAATGTCTTACCTGCTGTACCAAATGTTGTGTGGCATTAAGCACCTC
CATTCTGCTGGAATTATTCACAGGGATTTAAAACCAAGTAACATTGTAGTCAAGTCTGAT
TGCACATTGAAAATCCTGGACTTTGGACTGGCCAGGACAGCAGGCACAAGCTTCATGATG
ACTCCATATGTGGTGACACGTTATTACAGAGCCCCTGAGGTCATCCTGGGGATGGGCTAC
AAGGAGAACGTGGATATATGGTCTGTGGGATGCATTATGGGAGAAATGGTTCGCCACAAA
ATCCTCTTTCCAGGAAGGGACTATATTGACCAGTGGAATAAGGTAATTGAACAACTAGGA
ACACCATGTCCAGAATTCATGAAGAAATTGCAACCCACAGTAAGAAACTATGTGGAGAAT
CGGCCCAAGTATGCGGGACTCACCTTCCCCAAACTCTTCCCAGATTCCCTCTTCCCAGCG
GACTCCGAGCACAATAAACTCAAAGCCAGCCAAGCCAGGGACTTGTTGTCAAAGATGCTA
GTGATTGACCCAGCAAAAAGAATATCAGTGGACGACGCCTTACAGCATCCCTACATCAAC
GTCTGGTATGACCCAGCCGAAGTGGAGGCGCCTCCACCTCAGATATATGACAAGCAGTTG
GATGAAAGAGAACACACAATTGAAGAATGGAAAGAACTTATCTACAAGGAAGTAATGAAT
TCAGAAGAAAAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGTG
CAGCAGTGA

# Macromolecular_Interacting_Partner_24_GenBank_ID_Gene:
U07620

# Macromolecular_Interacting_Partner_24_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_24_Locus:
4q22.1-q23

# Macromolecular_Interacting_Partner_24_SNPs:
rs1460763; rs1460767; rs1031738; rs2869444; rs1460759; rs2199308; rs1460769; rs2199309; rs1108429; rs2904101; rs1031737; rs2869438; rs2869421; rs1460756; rs1460753; rs2290882; rs4611890; rs10008238; rs7670728; rs11097100; rs6810895; rs10010011; rs6825707; rs10029339; rs4693145; rs4693142; rs1903360; rs11097104; rs11097099; rs7655217; rs1599313; rs6531910; rs12499006; rs1460760; rs10213453; rs7349681; rs6531906; rs6855169; rs7694034; rs7666454; rs12650052; rs12505566; rs12512375; rs6531914; rs6825506; rs7699555; rs11932806; rs7687771; rs11943376; rs6810839; rs9884127; rs12507758; rs1460751; rs10004539; rs6531925; rs4132490; rs6817452; rs2904094; rs4385018; rs1903361; rs6858306; rs12641387; rs12509960; rs1031739; rs3926499; rs12498980; rs2869424; rs1460758; rs1460766; rs6829923; rs10021706; rs6531913; rs4693135; rs6531921; rs4235080; rs2904095; rs1599314; rs10213444; rs6531909; rs4693139; rs6839160; rs1460750; rs6845742; rs9999403; rs6531926; rs6531924; rs6531916; rs6852305; rs2290881; rs12646571; rs11097109; rs11938088; rs9990599; rs11736313; rs1460752; rs7654796; rs4608765; rs12505959; rs6832259; rs7666231; rs1460757; rs6829870; rs2904097; rs6811046; rs10856859; rs6531911; rs9307018; rs2904090; rs2869437; rs6531905; rs6828947; rs7678480; rs9994931; rs12513293; rs958; rs12513374; rs4235079; rs7680934; rs4693765; rs12648265; rs10010952; rs2904096; rs2199307; rs4597789; rs7669060; rs12511071; rs6823664; rs2869435; rs10011429; rs11939109; rs6531923; rs7656914; rs6844365; rs6531907; rs6827698; rs11097103; rs11097110; rs10213451; rs7665868; rs12505595; rs6845605; rs12640395; rs2869431; rs1460761; rs4693766; rs6531915; rs7695155; rs12512698; rs7667999; rs7690384; rs11946235; rs10516768; rs7669487; rs2869436; rs12507513; rs7684258; rs12505532; rs17451111; rs1466380; rs17409925; rs6825521; rs1460754; rs17253274; rs12505336; rs7694920; rs6826702; rs2904099; rs7684081; rs11930495; rs13115429; rs6822338; rs11941150; rs7674849; rs6531922; rs2869432; rs13115172; rs12508545; rs6531918; rs2035056; rs12503051; rs11097107; rs6851183; rs17011890; rs7695707; rs7688633; rs12508801; rs11097108; rs11941484; rs4114893; rs7699065; rs7669675; rs6531927; rs2904105; rs2869433; rs7677400; rs12646021; rs11929810; rs13129883; rs13146797; rs11929779; rs12498923; rs6821819; rs11726269; rs11942064; rs12513237; rs10516771; rs4693763; rs13111170; rs11097098; rs12511667; rs12640392; rs7699047; rs17011519; rs6842671; rs17449485; rs11947870; rs6531928; rs7684469; rs13104178; rs10516774; rs12508939; rs7683561; rs6852494; rs6531917; rs17417318; rs6851604; rs7657056; rs13132206; rs6844363; rs7699333; rs13138286; rs11944466; rs12501551; rs17409687; rs1380922; rs9654156; rs12510302; rs11929783; rs17011893; rs11935211; rs17011645; rs11946258; rs9997633; rs17011756; rs12645370; rs7685419; rs4488910; rs6829766; rs7668374; rs4693143; rs17011584; rs7688651; rs2126021; rs6856688; rs12508372; rs11725943; rs12505800; rs6531912; rs4693140; rs12511114; rs7684518; rs17011445; rs7683909; rs10516773; rs10003259; rs10516770; rs2035057; rs17409311; rs10030319; rs7655797; rs12502371; rs12508579; rs11097102; rs2904102; rs2869439; rs12508286; rs7678392; rs10026060; rs12644920; rs7678691; rs10516769; rs11932102; rs9654157; rs13130598; rs1599312; rs4693144; rs6844343; rs7691626; rs7699105; rs12500132; rs10034428; rs17449015; rs7440491; rs7656010; rs2869422; rs11737795; rs6849834; rs12510373; rs4613534; rs4389539; rs17011705; rs922195; rs17011617; rs12513122; rs6531904; rs12513353; rs1460755; rs7685683; rs10516772; rs2904093; rs7698274; rs10022904; rs4693141; rs11097106; rs12504127; rs7437117; rs12500543; rs9307016; rs4693761; rs16996040; rs12501743; rs17418062; rs17011654; rs7684570; rs7679269; rs6827098; rs12504929; rs13146802; rs17011479; rs17011870; rs17011564; rs4693764; rs11726550; rs17011659; rs7696982; rs12649297; rs17011402; rs4693137; rs17011489; rs10016847; rs11725624; rs6830872; rs17011568; rs17415651; rs17011516; rs7684758; rs17450224; rs7677251; rs12500319; rs6814005; rs17011467; rs6847300; rs12646076; rs17452273; rs17011913; rs3733367; rs17011621; rs10035072; rs7689808; rs1380923; rs769378; rs6853248; rs9715454; rs10019269; rs17011457; rs7687046; rs6827405; rs2869423; rs1841427; rs6843457; rs11097101; rs11943324; rs9762809; rs17409527; rs17449147; rs10010751; rs1460762; rs10009161; rs12504532; rs17011731; rs6836561; rs17011611; rs17011847; rs10025305; rs7687161; rs12651511; rs17011653; rs7696980; rs17011419; rs7661197; rs7663388; rs6827483; rs10028202; rs6826762; rs6816691; rs9762806; rs17011588; rs17011421; rs17011575; rs12331353; rs7687972; rs12505443; rs7693923; rs6832461; rs17011396; rs17011409; rs7662140; rs6851072; rs4449380; rs12499209; rs17011458; rs10030225; rs17011492; rs9997175; rs12511602; rs17011592; rs17011547; rs11943129; rs2869430; rs17011630; rs1841426; rs10031237; rs17418221; rs17409478; rs12509902; rs11931871; rs17011649; rs6831576; rs12507860; rs17011487; rs769377; rs9762814; rs17011843; rs17417758; rs17408832; rs17011623; rs12503520; rs6847482; rs10034589; rs17011472; rs7696316; rs12640131; rs7654907; rs17011607; rs17011400; rs1903362; rs17011460; rs12508926; rs6818726; rs1460765; rs4521313; rs13112020; rs12509769; rs17011577; rs17409637; rs17011875; rs10026338; rs12646706; rs10470881; rs17449582; rs7691172; rs13140626; rs12502087; rs17011410; rs11935348; rs6841973; rs12506828; rs6829684; rs12498902; rs7661679; rs17011397; rs11097105; rs7676652; rs17011432; rs3762915; rs17011590; rs17011459; rs11947620; rs13110630; rs10006563; rs17011551; rs6811435; rs7663763; rs1318492; rs6531908; rs1903363; rs6842530; rs17011526; rs7663773; rs6813859; rs6817640; rs10019871; rs10030197; rs17408881; rs12500023; rs6831589; rs7682129; rs17011803; rs12511499; rs7697017; rs7661809; rs6813724; rs9994380; rs7690323; rs17011537; rs4371581; rs17011522; rs4693753; rs17451306; rs10006000; rs1460764; rs13112340; rs1460749; rs17011533; rs10003756; rs17011428; rs12511135; rs9996693; rs7698396; rs6845334; rs6824346; rs17011556; rs2904100; rs10213302; rs17409904; rs17011821; rs17011407; rs6826951; rs17011655; rs7667204; rs13115030; rs4299551; rs13140948; rs17011573; rs2035058; rs17011540; rs2009855; rs6847635; rs12500076; rs9994303; rs2589506; rs1436527; rs2589514; rs1436524; rs1469869; rs1436521; rs2589518; rs1541998; rs2282596; rs1946733; rs6822478; rs7435363; rs4403040; rs4693754; rs10004712; rs4235078; rs1898248; rs12502902; rs4546235; rs3775187; rs4352468; rs4334746; rs4613557; rs10028075; rs2118044; rs2282598; rs10031752; rs6531898; rs1436529; rs4501213; rs3775169; rs4377581; rs4482754; rs4364253; rs6821745; rs12647176; rs10024003; rs4407492; rs12639693; rs10001480; rs9307015; rs6856450; rs3775166; rs9884282; rs3775184; rs7692508; rs6810413; rs4133139; rs11929863; rs4487330; rs12642887; rs4693757; rs6854208; rs3775181; rs9995879; rs6848433; rs12650286; rs2282597; rs3775168; rs6815306; rs3775182; rs7692460; rs12640230; rs3775164; rs10212744; rs4530621; rs3775183; rs11097091; rs2575673; rs17011341; rs10009993; rs12644947; rs3775170; rs4414944; rs13103374; rs9307014; rs12647506; rs12502934; rs1469870; rs7670470; rs10003556; rs4446299; rs13112959; rs2575672; rs3775173; rs1436522; rs9884770; rs3775180; rs4351013; rs7692676; rs10033283; rs3775167; rs10212952; rs11097094; rs6531897; rs2043649; rs1010778; rs10020650; rs3775171; rs10011390; rs1002484; rs6531892; rs746438; rs4693136; rs7684198; rs11934691; rs7689936; rs3775176; rs17011324; rs6842186; rs10027764; rs4414943; rs7670786; rs4499692; rs7696878; rs6822410; rs10516763; rs7670681; rs13142206; rs12644938; rs10023731; rs3822036; rs3775175; rs11733961; rs11097092; rs17008675; rs2043650; rs6531893; rs12643642; rs7659520; rs12648064; rs10001162; rs9684602; rs17011322; rs5004884; rs12642872; rs17011339; rs17011349; rs10006261; rs2043648; rs4382028; rs7691896; rs6855234; rs9760017; rs10034271; rs1561154; rs10018678; rs4693756; rs10025882; rs6811151; rs10002407; rs2282599; rs10776485; rs4560400; rs4522858; rs10009942; rs3775185; rs7654005; rs3755971; rs1898249; rs3822037; rs13114632; rs6531891; rs6846365; rs9996208; rs6854511; rs7697197; rs7686599; rs17011355; rs6840318; rs13103861; rs13121113; rs5006575; rs12512583; rs2282595; rs7439672; rs12648171; rs11934127; rs2575674; rs7699978; rs2589515; rs1201; rs2575675; rs1202; rs2589516; rs12512524; rs17011312; rs10032602; rs17011314; rs7660160; rs28760360; rs34414912; rs17450827; rs34255377; rs35547091; rs34168022; rs17011766; rs4458422; rs28536101; rs34262586; rs35517015; rs35294861; rs35501076; rs4608763; rs6849947; rs4129300; rs11435039; rs4269144; rs5860021; rs7436985; rs10534985; rs28896887; rs35116135; rs1115229; rs35217429; rs10671229; rs17416927; rs28839895; rs3527; rs7661648; rs17450910; rs13140380; rs35435792; rs34369854; rs17011858; rs34455560; rs9968336; rs35140130; rs3029315; rs35842829; rs12498558; rs7442188; rs28489900; rs28804774; rs28834688; rs7695670; rs35882077; rs35610513; rs34648043; rs34904465; rs6815085; rs28830848; rs17011643; rs34442411; rs35257599; rs35178184; rs11943866; rs34265383; rs28421956; rs4693769; rs17011682; rs34328856; rs35085432; rs35034762; rs7691277; rs33970548; rs35338513; rs35581530; rs11278816; rs34061649; rs34304791; rs35461035; rs13124817; rs34743167; rs35892134; rs7376405; rs17409269; rs11330422; rs35492319; rs36216983; rs17011720; rs13113317; rs10539886; rs13149041; rs6839310; rs28733919; rs17011696; rs34683010; rs10608638; rs4561895; rs4994993; rs36228436; rs7679167; rs28520822; rs28695505; rs34809402; rs34253891; rs34870954; rs28463620; rs28670086; rs28722990; rs7675381; rs9307017; rs34885616; rs17011700; rs28534721; rs34954949; rs35572072; rs34989577; rs35859687; rs35240319; rs10600798; rs35991788; rs4618275; rs35774265; rs13124872; rs11947890; rs28450091; rs9998205; rs33949420; rs3030118; rs35450214; rs3030160; rs12644976; rs13126246; rs6850992; rs35900214; rs33991102; rs34241060; rs28373627; rs34593390; rs28661214; rs7697335; rs34125064; rs35130751; rs35441446; rs6844636; rs35767206; rs35145865; rs13126021; rs13113315; rs6836359; rs35826931; rs7690940; rs28408117; rs9654155; rs35063332; rs34696102; rs17011690; rs6856862; rs33929180; rs7673423; rs35083678; rs35343868; rs12644859; rs36021595; rs2001612; rs10681488; rs28791572; rs13145464; rs13113328; rs35965801; rs34448816; rs5860022; rs28694187; rs28890938; rs34498673; rs28536743; rs10545105; rs9761579; rs12500128; rs13116387; rs35427609; rs10016000; rs28434311; rs10591715; rs28705770; rs3971920; rs7672563; rs3217717; rs28821771; rs35079757; rs12650508; rs3030142; rs13129988; rs3029313; rs7688495; rs34505400; rs10714569; rs35097345; rs12643272; rs34201683; rs17417827; rs35609863; rs10014678; rs28427030; rs34111505; rs11944190; rs34111165; rs36223042; rs2219590; rs34184989; rs13140549; rs2169232; rs9994347; rs36076697; rs34790740; rs28870188; rs34783569; rs10639041; rs1460768; rs34676161; rs28626971; rs35003006; rs35334656; rs5860019; rs34911547; rs13124881; rs5860023; rs4434210; rs10711609; rs35968542; rs34447604; rs35808523; rs2869434; rs11728235; rs10716571; rs17011853; rs36004445; rs13118244; rs34637756; rs28613556; rs34024985; rs11284646; rs10538760; rs34570949; rs35129937; rs34800738; rs35795436; rs13112890; rs10639042; rs34816270; rs34609132; rs35817774; rs34547847; rs9761874; rs28515691; rs11439209; rs6531899; rs28416998; rs35412018; rs33976873; rs35103650; rs35022866; rs17011806; rs36124809; rs11730779; rs34575399; rs11942108; rs28847910; rs35757767; rs28406787; rs34973055; rs34192441; rs35160765; rs3030124; rs28702698; rs34721708; rs2007976; rs28803851; rs35324025; rs35888867; rs7437697; rs13132706; rs28664010; rs34477595; rs34503531; rs28755839; rs6844802; rs6853290; rs4693762; rs34748597; rs4349565; rs17011815; rs35573944; rs35122643; rs4450887; rs33935168; rs33945648; rs28830922; rs13145461; rs3030114; rs28734891; rs11097095; rs10550573; rs13124525; rs35907363; rs28444287; rs34243707; rs6831733; rs13148508; rs28722583; rs35977040; rs28759971; rs35108904; rs34854999; rs34863847; rs13116803; rs13126094; rs10708095; rs6836163; rs4575960; rs35272630; rs10549069; rs9998829; rs28559713; rs4608764; rs13113779; rs12501090; rs34163860; rs17011764; rs6850605; rs4132491; rs35788198; rs34332756; rs35118208; rs7677406; rs35867435; rs35288754; rs34210154; rs34914334; rs36211477; rs28411373; rs36078401; rs10020888; rs34364808; rs28404815; rs35161743; rs28803213; rs13140707; rs35212998; rs36184857; rs7675359; rs11458660; rs28630852; rs17011897; rs35173052; rs28816476; rs35031715; rs9715449; rs34743978; rs17011767; rs17011845; rs17011819; rs12650517; rs5860024; rs34063796; rs34805580; rs34544666; rs35455450; rs34043435; rs13136303; rs35816063; rs11460057; rs36057902; rs10020889; rs35443953; rs13434575; rs11097096; rs13140740; rs11404211; rs36023771; rs34608518; rs34467283; rs6810953; rs36041399; rs35960605; rs34388593; rs35240246; rs28425193; rs17011774; rs3030110; rs35952969; rs11734792; rs17011872; rs11339874; rs36092105; rs35696959; rs17011708; rs28583812; rs28722082; rs13117193; rs34440566; rs35443845; rs6844573; rs11931070; rs34404446; rs35565125; rs34624037; rs11722341; rs17409562; rs11941923; rs7442324; rs10642552; rs35087395; rs10639063; rs28812808; rs13140361; rs35463589; rs35199525; rs28433471; rs8180149; rs28572764; rs28826941; rs28792132; rs2035055; rs13136895; rs28849082; rs4994992; rs34215628; rs13124639; rs11944647; rs34238796; rs13145457; rs34601352; rs28411372; rs13126019; rs5860025; rs9714693; rs35869982; rs11932859; rs7699144; rs10012013; rs34470194; rs13147005; rs11097097; rs13112497; rs34486987; rs34813710; rs36101511; rs6814123; rs34135924; rs34034936; rs11936320; rs28783973; rs12331772; rs28529458; rs34328097; rs13134099; rs13120126; rs33935094; rs10538012; rs6856365; rs17011354; rs17405567; rs7681267; rs34159031; rs35755826; rs6856155; rs35865395; rs28514916; rs9760243; rs10027225; rs1436523; rs1987599; rs35218486; rs5860017; rs13111648; rs3836594; rs10856856; rs34899473; rs28552906; rs3775186; rs35404583; rs41457050; rs28399149; rs34537730; rs5860013; rs35663996; rs34749448; rs34122764; rs36212057; rs7681951; rs34850141; rs13148731; rs34756998; rs13104555; rs35660849; rs35588497; rs34998174; rs35833770; rs34581941; rs4289439; rs7692668; rs34476895; rs5022021; rs13125713; rs28578870; rs34929575; rs36216172; rs12503688; rs4572869; rs28485608; rs34729900; rs4479697; rs34807837; rs34836858; rs4693755; rs34074833; rs34494584; rs34641637; rs13125729; rs11447293; rs4305506; rs34490730; rs13110593; rs36051698; rs28602213; rs17011338; rs5860016; rs33967580; rs28564356; rs35529605; rs6833404; rs13137708; rs33915987; rs28886577; rs733245; rs35534226; rs35394196; rs34038586; rs34324822; rs11413469; rs34699430; rs34770162; rs28538268; rs28516651; rs34050480; rs35076380; rs11360333; rs34741254; rs5860012; rs10538907; rs13104186; rs4345173; rs3841985; rs34825310; rs5860015; rs35211423; rs7667297; rs13353771; rs6823292; rs6813473; rs6531890; rs36085847; rs34949899; rs3775174; rs3822035; rs28660296; rs10635481; rs35495063; rs34886510; rs13146800; rs28895314; rs35606170; rs28709251; rs13104858; rs6818736; rs28435171; rs35225779; rs28576440; rs34300479; rs33962451; rs4419471; rs36047555; rs35893712; rs35915959; rs6813767; rs28398988; rs993593; rs11464313; rs34890849; rs28538338; rs35985560; rs35971482; rs983362; rs6821840; rs35438921; rs13434461; rs35278948; rs28754957; rs35080222; rs35280239; rs35466444; rs34937342; rs7667730; rs35320793; rs36047328; rs4382027; rs35279016; rs34751931; rs1436525; rs34439623; rs34952784; rs35891526; rs35823399; rs28409011; rs33977029; rs34155854; rs5860011; rs5860014; rs11721577; rs6531896; rs28846216; rs34180438; rs35107154; rs11432370; rs28594219; rs35490865; rs35333179; rs41279295; rs13138031; rs6825701; rs34158309; rs33990825; rs11309220; rs34791873; rs35136227; rs36132996; rs2060588; rs28639372; rs35568742; rs1436526; rs36133086; rs33951909; rs28756326; rs35187473; rs41282389; rs6857877; rs6843159; rs34188118; rs34534392; rs33979648; rs34789840; rs35273363; rs6816545; rs34498081; rs35358194; rs28865277; rs28562760; rs34934309; rs34060265; rs3775172; rs9762665; rs34562438; rs28625279; rs34725089; rs13104097; rs34757256; rs28642002; rs35270911; rs28684379; rs7681273; rs35485855; rs35867054; rs28360921; rs34134501; rs28394598; rs34008671; rs35473638; rs34307500; rs35112097; rs7660151; rs10034578; rs17011284; rs17011286; rs17011297; rs17011308; rs1946734; rs2164535; rs2575676; rs2589509; rs2589523; rs2589525; rs3755970; rs4640664; rs7438872; rs7439032; rs7677101

# Macromolecular_Interacting_Partner_24_General_References:
7826642; 8654373; 10715136; 9739089

# Macromolecular_Interacting_Partner_24_References:
16854387

# Macromolecular_Interacting_Partner_25_ID:
7682

# Macromolecular_Interacting_Partner_25_Name:
Interleukin-2 precursor

# Macromolecular_Interacting_Partner_25_Synonyms:
IL-2; T-cell growth factor; TCGF; Aldesleukin

# Macromolecular_Interacting_Partner_25_Gene_Name:
IL2

# Macromolecular_Interacting_Partner_25_Protein_Sequence:
>Interleukin2 precursor
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT

# Macromolecular_Interacting_Partner_25_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_25_Molecular_Weight:
17628

# Macromolecular_Interacting_Partner_25_Theoretical_pI:
7.95

# Macromolecular_Interacting_Partner_25_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-2 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_25_General_Function:
Not Available

# Macromolecular_Interacting_Partner_25_Specific_Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells

# Macromolecular_Interacting_Partner_25_Pathway:
Not Available

# Macromolecular_Interacting_Partner_25_Reaction:
Not Available

# Macromolecular_Interacting_Partner_25_Pfam_Domain_Function:
PF00715:IL2

# Macromolecular_Interacting_Partner_25_Signals:
1-20

# Macromolecular_Interacting_Partner_25_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_25_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_25_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_25_GenBank_ID_Protein:
5729676

# Macromolecular_Interacting_Partner_25_SwissProt_ID:
IL2_HUMAN (P60568)

# Macromolecular_Interacting_Partner_25_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_25_Genecard_id:
IL2

# Macromolecular_Interacting_Partner_25_Geneatlas_id:
IL2

# Macromolecular_Interacting_Partner_25_hgnc_id:
HGNC:6001

# Macromolecular_Interacting_Partner_25_PDB_ID:
1PW6

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_25_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_25_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_25_Gene_Sequence:
>462 bp
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTGCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

# Macromolecular_Interacting_Partner_25_GenBank_ID_Gene:
J00264

# Macromolecular_Interacting_Partner_25_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_25_Locus:
4q26-q27

# Macromolecular_Interacting_Partner_25_SNPs:
rs3087209; rs2069763; rs2069778; rs2069769; rs2069764; rs2069779; rs1479920; rs2069768; rs2069765; rs1479921; rs2069771; rs2069772; rs2069773; rs2069770; rs2069777; rs2069776; rs2069762; rs2067006; rs2069774; rs1479922; rs11575812; rs10019970; rs11575810; rs1051753; rs34762647; rs35084452; rs2069767; rs34501152; rs11575807; rs41304870; rs33988980; rs34863848; rs34419809; rs2448491; rs2069766; rs11575808; rs2069760; rs2069775; rs11575811; rs36215455; rs2069780; rs36215457; rs36215454; rs11575813; rs2069761; rs35007569; rs36215456; rs35104399; rs10027390; rs11932411; rs13435525; rs1479923; rs1479924; rs2219865; rs3136534; rs4833248

# Macromolecular_Interacting_Partner_25_General_References:
6330695; 6403867; 6312994; 6306584; 6608729; 6324170; 7722480; 8824916; 3264184; 3491296; 6333684; 2793860; 3500515; 1631562; 1510960; 7529123

# Macromolecular_Interacting_Partner_25_References:
12875900; 14686796; 16318858; 16725211

# Macromolecular_Interacting_Partner_26_ID:
7351

# Macromolecular_Interacting_Partner_26_Name:
Histone H4

# Macromolecular_Interacting_Partner_26_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_26_Gene_Name:
HIST1H4A

# Macromolecular_Interacting_Partner_26_Protein_Sequence:
>Histone H4
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

# Macromolecular_Interacting_Partner_26_Number_of_Residues:
103

# Macromolecular_Interacting_Partner_26_Molecular_Weight:
11368

# Macromolecular_Interacting_Partner_26_Theoretical_pI:
11.91

# Macromolecular_Interacting_Partner_26_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  chromosome organization and biogenesis
Process:  chromosome organization and biogenesis (sensu Eukaryota)
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  protein complex assembly
Process:  nucleosome assembly
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus
Component:  protein complex
Component:  nucleosome

# Macromolecular_Interacting_Partner_26_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_26_Specific_Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling

# Macromolecular_Interacting_Partner_26_Pathway:
Not Available

# Macromolecular_Interacting_Partner_26_Reaction:
Not Available

# Macromolecular_Interacting_Partner_26_Pfam_Domain_Function:
PF00125:Histone

# Macromolecular_Interacting_Partner_26_Signals:
None

# Macromolecular_Interacting_Partner_26_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_26_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_26_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_26_GenBank_ID_Protein:
32097

# Macromolecular_Interacting_Partner_26_SwissProt_ID:
H4_HUMAN (P62805)

# Macromolecular_Interacting_Partner_26_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_26_Genecard_id:
HIST1H4A

# Macromolecular_Interacting_Partner_26_Geneatlas_id:
HIST1H4A

# Macromolecular_Interacting_Partner_26_hgnc_id:
HGNC:4781

# Macromolecular_Interacting_Partner_26_PDB_ID:
1EQZ

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_26_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_26_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_26_Gene_Sequence:
>312 bp
ATGTCCGGCTGTGGAAAGGGCGGAAAGGGCTTAGGCAAAGGTGGCGCTAAGCGCCACCGC
AAGGTCTTGAGAGACAACATTCAGGGCATCACCAAGCCTGCCATTCGGCGTNTAGCTCGG
CGTGGCGGCGTTAAGCGGATCTCTGGCCTCATTTACGAGGAGACCCGCGGTGTGCTGAAA
GTGTTCTTGGAGAATGTGATTCGGGACGCAGTCACCTACACCGAGCACGCCAAGCGCAAG
ACCGTCACAGCCATGGATGTGGTGTACGCGCTCAAGCGNCAGGGGAGNACCCTCTACGGC
TTCGGAGGCTAG

# Macromolecular_Interacting_Partner_26_GenBank_ID_Gene:
X00038

# Macromolecular_Interacting_Partner_26_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_26_Locus:
6p21.3

# Macromolecular_Interacting_Partner_26_SNPs:
Not Available

# Macromolecular_Interacting_Partner_26_General_References:
6314274; 3035717; 1916825; 7626218; 9031620; 9439656; 9119399; 12408966; 14574404; 3340182; 2474456

# Macromolecular_Interacting_Partner_26_References:
15210580; 15261456; 16904069

# Macromolecular_Interacting_Partner_27_ID:
7113

# Macromolecular_Interacting_Partner_27_Name:
Cytochrome c

# Macromolecular_Interacting_Partner_27_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_27_Gene_Name:
CYCS

# Macromolecular_Interacting_Partner_27_Protein_Sequence:
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE

# Macromolecular_Interacting_Partner_27_Number_of_Residues:
105

# Macromolecular_Interacting_Partner_27_Molecular_Weight:
11749

# Macromolecular_Interacting_Partner_27_Theoretical_pI:
10.16

# Macromolecular_Interacting_Partner_27_GO_Classification:
>>>
Function:  binding
Function:  tetrapyrrole binding
Function:  heme binding
Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_27_General_Function:
Energy production and conversion 

# Macromolecular_Interacting_Partner_27_Specific_Function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases

# Macromolecular_Interacting_Partner_27_Pathway:
Not Available

# Macromolecular_Interacting_Partner_27_Reaction:
Not Available

# Macromolecular_Interacting_Partner_27_Pfam_Domain_Function:
PF00034:Cytochrom_C

# Macromolecular_Interacting_Partner_27_Signals:
None

# Macromolecular_Interacting_Partner_27_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_27_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_27_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_27_GenBank_ID_Protein:
181242

# Macromolecular_Interacting_Partner_27_SwissProt_ID:
CYC_HUMAN (P99999)

# Macromolecular_Interacting_Partner_27_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_27_Genecard_id:
CYCS

# Macromolecular_Interacting_Partner_27_Geneatlas_id:
CYCS

# Macromolecular_Interacting_Partner_27_hgnc_id:
HGNC:19986

# Macromolecular_Interacting_Partner_27_PDB_ID:
1J3S

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_27_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_27_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Macromolecular_Interacting_Partner_27_Gene_Sequence:
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAA

# Macromolecular_Interacting_Partner_27_GenBank_ID_Gene:
M22877

# Macromolecular_Interacting_Partner_27_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_27_Locus:
7p15.2

# Macromolecular_Interacting_Partner_27_SNPs:
rs11769363; rs7810784; rs1861525; rs12700584; rs10215217; rs4719799; rs12700583; rs12700582; rs3846998; rs2107123; rs11548785; rs11548815; rs11548798; rs11548802; rs11548799; rs11548820; rs11548772; rs11548783; rs11548796; rs11548816; rs11548795; rs3211452; rs11548791; rs11548818; rs11548805; rs3211451; rs11548807; rs11548778; rs17851278; rs11548812; rs11548776; rs11548797; rs11548779; rs11548806; rs11548774; rs11548777; rs11427893; rs1137513; rs3173604; rs11548775; rs1060389; rs1137505; rs1137510; rs11548804; rs1801082; rs1060388; rs1137506; rs11548773; rs41275976; rs1137512; rs1137508; rs13310377; rs13310456; rs34522469; rs35325343; rs1137507; rs11548787; rs1137511; rs10230102; rs11548792; rs28376346; rs1137509; rs36061386; rs6967260; rs3040291; rs16873757; rs5882962; rs34102874; rs34500218; rs10238032; rs17150957; rs10278815; rs10279024; rs10951046; rs11489282; rs12700580; rs2107121; rs2107122; rs2391087; rs2717885; rs2717886

# Macromolecular_Interacting_Partner_27_General_References:
2849112; 12853948; 9515723

# Macromolecular_Interacting_Partner_27_References:
14559818; 15177505; 15781658

# Macromolecular_Interacting_Partner_28_ID:
7694

# Macromolecular_Interacting_Partner_28_Name:
Peroxisome proliferator-activated receptor alpha

# Macromolecular_Interacting_Partner_28_Synonyms:
PPAR-alpha

# Macromolecular_Interacting_Partner_28_Gene_Name:
PPARA

# Macromolecular_Interacting_Partner_28_Protein_Sequence:
>Peroxisome proliferatoractivated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

# Macromolecular_Interacting_Partner_28_Number_of_Residues:
468

# Macromolecular_Interacting_Partner_28_Molecular_Weight:
52226

# Macromolecular_Interacting_Partner_28_Theoretical_pI:
6.20

# Macromolecular_Interacting_Partner_28_GO_Classification:
>>>
Function:  steroid hormone receptor activity
Function:  transcription factor activity
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_28_General_Function:
Not Available

# Macromolecular_Interacting_Partner_28_Specific_Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids

# Macromolecular_Interacting_Partner_28_Pathway:
Not Available

# Macromolecular_Interacting_Partner_28_Reaction:
Not Available

# Macromolecular_Interacting_Partner_28_Pfam_Domain_Function:
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_28_Signals:
None

# Macromolecular_Interacting_Partner_28_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_28_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_28_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_28_GenBank_ID_Protein:
307341

# Macromolecular_Interacting_Partner_28_SwissProt_ID:
PPARA_HUMAN (Q07869)

# Macromolecular_Interacting_Partner_28_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_28_Genecard_id:
PPARA

# Macromolecular_Interacting_Partner_28_Geneatlas_id:
PPARA

# Macromolecular_Interacting_Partner_28_hgnc_id:
HGNC:9232

# Macromolecular_Interacting_Partner_28_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_28_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_28_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_28_Gene_Sequence:
>1407 bp
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGTGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGCGTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA

# Macromolecular_Interacting_Partner_28_GenBank_ID_Gene:
L02932

# Macromolecular_Interacting_Partner_28_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_28_Locus:
22q12-q13.1|22q13.31

# Macromolecular_Interacting_Partner_28_SNPs:
rs1800206; rs1800234; rs1800204; rs1800235; rs4253773; rs135547; rs129600; rs4253681; rs4253652; rs135552; rs135539; rs135542; rs4253655; rs12330015; rs9627046; rs135538; rs4253663; rs7364220; rs4253620; rs4253698; rs4253781; rs9626729; rs4253758; rs4253699; rs4253630; rs4253682; rs4253703; rs1555208; rs4253701; rs4253622; rs4253704; rs135549; rs4253665; rs4253686; rs4253792; rs6008259; rs4253702; rs4253669; rs135550; rs135543; rs4253621; rs4253788; rs4253678; rs4253695; rs4253791; rs5769177; rs4253674; rs4253671; rs4253641; rs4253624; rs5766696; rs4253639; rs4253618; rs7286168; rs4253786; rs4253784; rs4253651; rs4253757; rs4253800; rs8138102; rs4253635; rs4253670; rs4253789; rs11704856; rs4253660; rs4253645; rs9626736; rs4253797; rs135540; rs4253638; rs4253694; rs8135690; rs4253633; rs4253627; rs4253642; rs4253696; rs4253656; rs4253706; rs4253659; rs4253672; rs4253691; rs4253667; rs9306498; rs5766698; rs4253688; rs4253623; rs4253634; rs4253801; rs1055659; rs135548; rs4253687; rs4253707; rs4253646; rs6008970; rs4253664; rs4253643; rs4253700; rs4253668; rs135555; rs4253685; rs4253640; rs6008976; rs7287085; rs4253705; rs3892755; rs4253661; rs4253626; rs4253637; rs4253658; rs4253629; rs4253782; rs4253647; rs7289836; rs4253679; rs135551; rs4253793; rs4253617; rs4253692; rs4253631; rs4253644; rs4253625; rs9306499; rs4253790; rs4253787; rs4253683; rs4253619; rs4253662; rs4253657; rs5769178; rs4253756; rs4253684; rs4253636; rs135554; rs4253785; rs4253628; rs9626737; rs4253780; rs4253654; rs4253677; rs761543; rs4253783; rs4253648; rs11704979; rs4253680; rs4253616; rs9626814; rs4253653; rs4253693; rs4253673; rs4253632; rs4253650; rs4253689; rs11913649; rs4253666; rs4823902; rs11704508; rs5769243; rs10427717; rs8135547; rs9680739; rs8139731; rs17661656; rs3747246; rs41367645; rs17661718; rs9306500; rs5766804; rs135553; rs41388244; rs9615264; rs16994933; rs41427746; rs16994915; rs6007981; rs17241878; rs10154348; rs12162684; rs11705154; rs11703495; rs135541; rs12160659; rs7287027; rs4823586; rs6009111; rs41378347; rs12169296; rs135545; rs1134224; rs10775794; rs11703746; rs135536; rs9680676; rs12169290; rs9627268; rs5769366; rs17241885; rs7288994; rs9627100; rs7289495; rs1055657; rs6009081; rs135546; rs1800246; rs5767743; rs4253762; rs4253778; rs4253690; rs4823613; rs4253769; rs4253751; rs6008197; rs6519979; rs4253761; rs4253747; rs4253730; rs4253775; rs4253713; rs4253719; rs4253750; rs4253764; rs4253765; rs4253776; rs4253729; rs4253709; rs4253712; rs4253760; rs4253728; rs11090819; rs4253737; rs4253770; rs4253777; rs2336904; rs4253711; rs4253754; rs4253798; rs4253748; rs4253727; rs4253723; rs4253710; rs4253714; rs6008160; rs4253708; rs4253718; rs4253774; rs4253722; rs4253767; rs4253732; rs5766741; rs4253726; rs4253799; rs5767700; rs7364297; rs4253736; rs4253794; rs4253752; rs4253731; rs4253766; rs4253721; rs4253717; rs4253742; rs4253744; rs4253697; rs4253771; rs4253746; rs4253725; rs4253739; rs4253720; rs4253738; rs4253755; rs1800245; rs4253795; rs4253716; rs4253735; rs4253734; rs5766743; rs4253779; rs4253741; rs4253753; rs6007662; rs4253768; rs4253743; rs4253745; rs4253772; rs4253763; rs4253724; rs4253759; rs4253733; rs4253715; rs8139794; rs4253740; rs4253749; rs8139663; rs41397552; rs11090791; rs11702902; rs11090817; rs6008123; rs7291727; rs5769175; rs5767636; rs9615238; rs5767560; rs5766734; rs6008126; rs5767633; rs11090818; rs8140236; rs12170204; rs9626730; rs11705483; rs11913971; rs7292459; rs5767634; rs4823477; rs6413511; rs1800243; rs1800242; rs9615759; rs1042311; rs5767686; rs1800236; rs12167302; rs9615163; rs41418950; rs34666721; rs5769287; rs35328780; rs7292112; rs11383159; rs7364140; rs5769365; rs34148860; rs5845740; rs35404482; rs35249750; rs41403648; rs35988564; rs6009112; rs5845739; rs36096470; rs41532849; rs881740; rs9615524; rs7286871; rs12484245; rs13053358; rs11538240; rs35966870; rs34896841; rs35838035; rs10643430; rs13053293; rs5767779; rs12171095; rs41479847; rs28772875; rs6009058; rs4592961; rs9627007; rs34109484; rs12159525; rs12170381; rs5845741; rs135544; rs41406451; rs35398060; rs28369325; rs5769129; rs12160049; rs34857047; rs12159225; rs6008042; rs7364165; rs10561065; rs7289761; rs5769184; rs9626764; rs12159821; rs5766682; rs41362646; rs41465647; rs3840962; rs5769088; rs41371446; rs2238833; rs4823487; rs9626756; rs7290774; rs41368348; rs5769276; rs34001104; rs35552991; rs28716636; rs13055301; rs5767424; rs12167354; rs1055658; rs41477146; rs5769364; rs36096495; rs5769356; rs35281820; rs35038216; rs41371949; rs5769142; rs11703765; rs35808855; rs6009014; rs41489145; rs9626751; rs135537; rs41355347; rs34437230; rs9615534; rs6007965; rs12159097; rs9615784; rs11344804; rs5769219; rs9615523; rs16994976; rs9626716; rs28895660; rs41329344; rs35345592; rs41489148; rs1800244; rs13054427; rs11912612; rs11703766; rs36124248; rs12166902; rs6008974; rs13055320; rs5769112; rs41332048; rs12169623; rs5769206; rs36074474; rs35436527; rs13056945; rs8139926; rs9627217; rs6008089; rs10570542; rs34977841; rs11325484; rs35637220; rs9615694; rs17847852; rs4365564; rs5767667; rs8135879; rs12166737; rs5767617; rs5766714; rs9626745; rs2336905; rs6008193; rs9615695; rs7290878; rs1973929; rs28875881; rs41526048; rs35528985; rs12168403; rs34108706; rs34716781; rs9626811; rs41461946; rs12168939; rs6008129; rs34902389; rs12166868; rs10563623; rs10427969; rs8141725; rs4365565; rs5767650; rs34142992; rs9627047; rs7290473; rs5767708; rs6008149; rs34052175; rs11703314; rs6008161; rs10593071; rs35418581; rs11445888; rs35658961; rs34873839; rs10658167; rs41497148; rs35027666; rs6008116; rs34774436; rs11270575; rs34036883; rs35700219; rs6008093; rs6007639; rs13057868; rs28669215; rs11332243; rs41343752; rs28508200; rs2283673; rs5767618; rs28786744; rs10591809; rs12170430; rs12168830; rs12167549; rs34858419; rs13058348; rs8141442; rs6008191; rs6008096; rs5767763; rs35145000; rs28584795; rs6007673; rs7286742; rs12168937; rs28828403; rs35615646; rs34406573; rs13058552; rs6008130; rs12166556; rs13056831; rs9626742; rs34363509; rs9615487; rs5767320; rs34775146; rs9626709; rs12157295; rs10154668; rs1053332; rs11705226; rs12106599; rs12159251; rs135556; rs135557; rs135559; rs135560; rs135561; rs135562; rs14842; rs14843; rs16995065; rs16995067; rs16995069; rs5767842; rs6008923; rs717926; rs7284616; rs7289611; rs7291028; rs9626816; rs9626823; rs9627278; rs9627280; rs9627281; rs9627287

# Macromolecular_Interacting_Partner_28_General_References:
7684926; 7981125; 8993548; 10591208; 9238002; 10681503

# Macromolecular_Interacting_Partner_28_References:
12949056; 15068815; 16226051

# Macromolecular_Interacting_Partner_29_ID:
5240

# Macromolecular_Interacting_Partner_29_Name:
Histone acetyltransferase p300

# Macromolecular_Interacting_Partner_29_Synonyms:
E1A-associated protein p300

# Macromolecular_Interacting_Partner_29_Gene_Name:
EP300

# Macromolecular_Interacting_Partner_29_Protein_Sequence:
>Histone acetyltransferase p300
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGD
INQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINS
MVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGTNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQDMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQ
PLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMP
NMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGE
VRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNA
GDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQM
PTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQ
NPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPN
AAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSM
AQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNI
PLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTP
TPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPNAPLLPPQPATPLSQPAVSIEGQVSNPPSTSST
EVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELK
TEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVD
PQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYK
YCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHF
CEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVL
HHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGE
VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQE
YGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPP
SEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKE
LPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNK
SSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIP
CDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETR
WHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQ
SLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENK
CPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTG
QQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPG
PPPTAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHL
EPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISP
LKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPI
PGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGG
MSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYP
PQPQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSP
QQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHV
SPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNS
DLNSNLSQSTLDIH

# Macromolecular_Interacting_Partner_29_Number_of_Residues:
2414

# Macromolecular_Interacting_Partner_29_Molecular_Weight:
264147

# Macromolecular_Interacting_Partner_29_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_29_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  transcription coactivator activity
Function:  binding
Function:  protein binding
Function:  transcription factor binding
Function:  transcription cofactor activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_29_General_Function:
Not Available

# Macromolecular_Interacting_Partner_29_Specific_Function:
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes

# Macromolecular_Interacting_Partner_29_Pathway:
Not Available

# Macromolecular_Interacting_Partner_29_Reaction:
acetyl-CoA + histone = CoA + acetylhistone

# Macromolecular_Interacting_Partner_29_Pfam_Domain_Function:
PF00439:Bromodomain;
PF09030:Creb_binding;
PF06001:DUF902;
PF06010:DUF906;
PF02172:KIX;
PF02135:zf-TAZ;
PF00569:ZZ

# Macromolecular_Interacting_Partner_29_Signals:
None

# Macromolecular_Interacting_Partner_29_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_29_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_29_EC_Link:
EC 2.3.1.48

# Macromolecular_Interacting_Partner_29_GenBank_ID_Protein:
495301

# Macromolecular_Interacting_Partner_29_SwissProt_ID:
EP300_HUMAN (Q09472)

# Macromolecular_Interacting_Partner_29_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_29_Genecard_id:
EP300

# Macromolecular_Interacting_Partner_29_Geneatlas_id:
EP300

# Macromolecular_Interacting_Partner_29_hgnc_id:
HGNC:3373

# Macromolecular_Interacting_Partner_29_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_29_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_29_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_29_Gene_Sequence:
>7245 bp
ATGGCCGAGAATGTGGTGGAACCGGGGCCGCCTTCAGCCAAGCGGCCTAAACTCTCATCT
CCGGCCCTCTCGGCGTCCGCCAGCGATGGCACAGATTTTGGCTCTCTATTTGACTTGGAG
CACGACTTACCAGATGAATTAATCAACTCTACAGAATTGGGACTAACCAATGGTGGTGAT
ATTAATCAGCTTCAGACAAGTCTTGGCATGGTACAAGATGCAGCTTCTAAACATAAACAG
CTGTCAGAATTGCTGCGATCTGGTAGTTCCCCTAACCTCAATATGGGAGTTGGTGGCCCA
GGTCAAGTCATGGCCAGCCAGGCCCAACAGAGCAGTCCTGGATTAGGTTTGATAAATAGC
ATGGTCAAAAGCCCAATGACACAGGCAGGCTTGACTTCTCCCAACATGGGGATGGGCACT
AGTGGACCAAATCAGGGTCCTACGCAGTCAACAGGTATGATGAACAGTCCAGTAAATCAG
CCTGCCATGGGAATGAACACAGGGACGAATGCGGGCATGAATCCTGGAATGTTGGCTGCA
GGCAATGGACAAGGGATAATGCCTAATCAAGTCATGAACGGTTCAATTGGAGCAGGCCGA
GGGCGACAGGATATGCAGTACCCAAACCCAGGCATGGGAAGTGCTGGCAACTTACTGACT
GAGCCTCTTCAGCAGGGCTCTCCCCAGATGGGAGGACAAACAGGATTGAGAGGCCCCCAG
CCTCTTAAGATGGGAATGATGAACAACCCCAATCCTTATGGTTCACCATATACTCAGAAT
CCTGGACAGCAGATTGGAGCCAGTGGCCTTGGTCTCCAGATTCAGACAAAAACTGTACTA
TCAAATAACTTATCTCCATTTGCTATGGACAAAAAGGCAGTTCCTGGTGGAGGAATGCCC
AACATGGGTCAACAGCCAGCCCCGCAGGTCCAGCAGCCAGGTCTGGTGACTCCAGTTGCC
CAAGGGATGGGTTCTGGAGCACATACAGCTGATCCAGAGAAGCGCAAGCTCATCCAGCAG
CAGCTTGTTCTCCTTTTGCATGCTCACAAGTGCCAGCGCCGGGAACAGGCCAATGGGGAA
GTGAGGCAGTGCAACCTTCCCCACTGTCGCACAATGAAGAATGTCCTAAACCACATGACA
CACTGCCAGTCAGGCAAGTCTTGCCAAGTGGCACACTGTGCATCTTCTCGACAAATCATT
TCACACTGGAAGAATTGTACAAGACATGATTGTCCTGTGTGTCTCCCCCTCAAAAATGCT
GGTGATAAGAGAAATCAACAGCCAATTTTGACTGGAGCACCCGTTGGACTTGGAAATCCT
AGCTCTCTAGGGGTGGGTCAACAGTCTGCCCCCAACCTAAGCACTGTTAGTCAGATTGAT
CCCAGCTCCATAGAAAGAGCCTATGCAGCTCTTGGACTACCCTATCAAGTAAATCAGATG
CCGACACAACCCCAGGTGCAAGCAAAGAACCAGCAGAATCAGCAGCCTGGGCAGTCTCCC
CAAGGCATGCGGCCCATGAGCAACATGAGTGCTAGTCCTATGGGAGTAAATGGAGGTGTA
GGAGTTCAAACGCCGAGTCTTCTTTCTGACTCAATGTTGCATTCAGCCATAAATTCTCAA
AACCCAATGATGAGTGAAAATGCCAGTGTGCCCTCCCTGGGTCCTATGCCAACAGCAGCT
CAACCATCCACTACTGGAATTCGGAAACAGTGGCACGAAGATATTACTCAGGATCTTCGA
AATCATCTTGTTCACAAACTCGTCCAAGCCATATTTCCTACGCCGGATCCTGCTGCTTTA
AAAGACAGACGGATGGAAAACCTAGTTGCATATGCTCGGAAAGTTGAAGGGGACATGTAT
GAATCTGCAAACAATCGAGCGGAATACTACCACCTTCTAGCTGAGAAAATCTATAAGATC
CAGAAAGAACTAGAAGAAAAACGAAGGACCAGACTACAGAAGCAGAACATGCTACCAAAT
GCTGCAGGCATGGTTCCAGTTTCCATGAATCCAGGGCCTAACATGGGACAGCCGCAACCA
GGAATGACTTCTAATGGCCCTCTACCTGACCCAAGTATGATCCGTGGCAGTGTGCCAAAC
CAGATGATGCCTCGAATAACTCCACAATCTGGTTTGAATCAATTTGGCCAGATGAGCATG
GCCCAGCCCCCTATTGTACCCCGGCAAACCCCTCCTCTTCAGCACCATGGACAGTTGGCT
CAACCTGGAGCTCTCAACCCGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAAC
CAGGGCCAGTTCCTTCCTCAGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATC
CCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGTCTAGTTCTTCC
TGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCC
CAGCTTCCTCAACCAGCTCTTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCC
ACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAACAACAATTCCA
GCCCCTGTTCCTACACCACCAGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCC
CCTCCAAGGCAGACACCTACACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCA
CTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCACAGCAGAGCACA
GCAGCGTCTGTTCCTACCCCAAACGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTT
TCCCAGCCAGCTGTAAGCATTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACA
GAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGAAGATGGAGGCC
AAAATGGAAGTGGATCAACCAGAACCAGCAGATACGCAGCCGGAGGATATTTCAGAGTCT
AAAGTGGAAGACTGTAAAATGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAA
ACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGTCATCTCCGGCT
CCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCA
ACATTGGAGGCACTTTACCGTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGAC
CCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCATGGATCTTTCT
ACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGAT
ATTTGGCTTATGTTCAATAATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAA
TACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGATGCAAAGCCTT
GGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAA
CAGTTGTGCACAATACCTCGTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTC
TGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGGATGACCCTTCC
CAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGAT
CCTGAACTGTTTGTTGAATGTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTT
CACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAAAGAAAAGTGCA
CGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACC
TTTCTAGAGAATCGTGTGAATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAG
GTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAACCAGGCATGAAA
GCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTC
TTTGCCTTTGAAGAAATTGATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAG
TATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTTACCTCGATAGT
GTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGA
TATTTAGAATATGTCAAGAAATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCA
AGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGATACCCAAGCCC
AAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTC
CATGACTACAAGGATATTTTTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAA
TTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCATTAAGGAACTG
GAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTG
ACCAAGGGAGACAGCAAAAATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAG
AGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTATCTAACGACCTC
TCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTC
ATTGCTGGCCCTGCTGCCAACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCC
TGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACAAGCACCTGGAG
TTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACG
CAGAGCCAGGACCGCTTTGTCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGC
TGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATAACACTAAAAAC
CATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAG
GCTGCAGCCACCCAGAGCCCAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAG
TCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCATCCTGCCAGAAG
ATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCC
ATCTGCAAGCAGCTCATTGCCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAA
TGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAACAGCTGCAGCAC
CGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTG
GTTGGGCAGCAACAGGGCCTCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGC
CAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGCCTACCCCTCCC
AATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAG
GCAGCAGGCCAGGTGACCCCTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGG
CCCCCACCTACAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGGAGACGCAGCGC
CAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACT
CCCATGGCCCCCATGGGTATGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTG
GAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCCAAGGAGGATTG
CCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAG
CATGGTCAACCTTTGAACATGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCA
CTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGACTCTCAGGTCT
CCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTG
TTGGCTGCATTCATCAAGCAGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATC
CCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTACCATGCCAGGT
CAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTT
CAGAGGGCTGGCCTGCCCCAGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGG
ATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTTCACAATTCCGA
GACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGA
ATAGGCCCTGGAATGGCCAACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCA
CCACAGCCGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAGGAAATATGGGA
CAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTAT
CAGCAGCGACTCCTTCAGCAACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCC
CAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCCAGCAGATCCCT
AATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCC
CAGCCCCCCCACTCCAGTCCTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTT
TCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCAACCCCATGGAA
CAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCA
GGCATGGCAAACCTCCATGGTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCA
GACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAG

# Macromolecular_Interacting_Partner_29_GenBank_ID_Gene:
U01877

# Macromolecular_Interacting_Partner_29_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_29_Locus:
22q13.2

# Macromolecular_Interacting_Partner_29_SNPs:
rs20551; rs1046088; rs4822012; rs20554; rs11912899; rs35560602; rs17002310; rs17002307; rs11704815; rs3210590; rs2076577; rs1569858; rs5751053; rs3818120; rs2057070; rs4822006; rs738628; rs4822011; rs5758231; rs7286979; rs5758238; rs2267424; rs5758242; rs9611510; rs5758235; rs1033611; rs4820429; rs4822004; rs5758251; rs766314; rs1983674; rs9611509; rs2064560; rs4820431; rs5758237; rs2144342; rs9619939; rs2207583; rs5751057; rs17002314; rs9623334; rs6002260; rs3818121; rs6002267; rs5751046; rs2273227; rs4822005; rs738629; rs9619941; rs9619950; rs738631; rs12167662; rs9611505; rs1569857; rs2294976; rs11090039; rs9623344; rs9611497; rs4820428; rs5758223; rs6002271; rs9623332; rs738632; rs2064558; rs5751048; rs5758241; rs2413637; rs2076578; rs12170811; rs17433014; rs2024717; rs2267426; rs5758247; rs12170429; rs17002284; rs12330117; rs4822014; rs9611503; rs7510675; rs8138205; rs730811; rs6002262; rs5751049; rs17002305; rs11912447; rs5758243; rs17002312; rs738630; rs5995996; rs5751056; rs17002318; rs5758240; rs2267425; rs2076581; rs7284319; rs5758236; rs17002301; rs5758239; rs17384028; rs4822008; rs4822010; rs8135637; rs9623331; rs11704042; rs17002304; rs8135084; rs5751058; rs17002308; rs9611500; rs4822007; rs9607772; rs4822013; rs5758228; rs5758246; rs79540; rs5751050; rs2899344; rs9607776; rs9619942; rs5751042; rs8137709; rs17002316; rs9611502; rs4822003; rs6002259; rs9623327; rs8141750; rs3788583; rs1033612; rs5758252; rs7285319; rs34013924; rs28937578; rs11350445; rs12628803; rs34985152; rs1802551; rs34842722; rs1062983; rs35530321; rs35508493; rs5845490; rs34217877; rs12158004; rs28579460; rs2076582; rs6002265; rs36083653; rs33937254; rs5751040; rs9611496; rs4820430; rs9623343; rs35609068; rs13058113; rs12168000; rs5751060; rs3216439; rs12160751; rs34818464; rs34424914; rs12169381; rs3216438; rs7285761; rs5751043; rs8142938; rs34299910; rs36012453; rs8136962; rs12628857; rs2273228; rs9623342; rs5758233; rs35609995; rs10529110; rs13057384; rs35333608; rs4822009; rs2413636; rs12160994; rs5758225; rs13057037; rs6002268; rs12165625; rs9619945; rs9607777; rs12163510; rs5758249; rs9611495; rs34942055; rs9619940; rs28391542; rs28514345; rs9619947; rs35823862; rs35350688; rs34731157; rs9607778; rs34149267; rs28477413; rs34868121; rs35121045; rs9611501; rs4605475; rs35497681; rs35669783; rs9623323; rs11362436; rs9623328; rs9623324; rs2064559; rs13056241; rs5758224; rs34711608; rs5758248; rs34509811; rs9607773; rs10854741; rs28733661; rs35616327; rs9611499; rs13053538; rs9623340; rs9611504; rs11415780; rs9623338; rs130087; rs33960382; rs5758234; rs9607774; rs5845489; rs9623339; rs9619946; rs9611508; rs34411551; rs35715259; rs11090041; rs5751041; rs11388493; rs5845488; rs12628137; rs2076579; rs5751055; rs7511178; rs35843389; rs35189661; rs34597174; rs2267427; rs34016471; rs35023864; rs5995997; rs36068453; rs11387442; rs35261244; rs1065580; rs34564005; rs34839216; rs2076580; rs9619937; rs6002274; rs9619943; rs35506286; rs13055654; rs3044636; rs5758230; rs10711010; rs35429134; rs6002266; rs130086; rs9623329; rs13055991; rs35304365; rs34339178; rs35082633; rs35403189; rs7291735; rs35343837; rs9607775; rs9611498; rs13055872; rs9619949; rs34914831; rs33917644; rs9611507; rs136393; rs28631247; rs12158776; rs13055866; rs6002269; rs13057044; rs13058482; rs34213429; rs5751051; rs35507631; rs10717148; rs3830876; rs34420363; rs11473253; rs5751045; rs35079921; rs5995998; rs17002286; rs34481158; rs5751054; rs35492332; rs11306415; rs2294977; rs9619944; rs12170320; rs5758245; rs13056242; rs35498541; rs10222217; rs9653841; rs9607779; rs13053662; rs10533459; rs28444825; rs9611506; rs35531014; rs9623336; rs4479527; rs5995993; rs7285973; rs35871884; rs12167653; rs9623335; rs9619938; rs35055551; rs34022257; rs35196722; rs1569856; rs28456102; rs5758226; rs36068041; rs35147987; rs34835519; rs34955001; rs35790144; rs35741493; rs34902876; rs12628695; rs136394; rs17002324; rs2143694; rs4822002; rs5751037; rs5758221; rs5758222; rs6002279; rs7287970

# Macromolecular_Interacting_Partner_29_General_References:
7523245; 11701890; 8945521; 8684459; 8917528; 9590696; 10823961; 11349124; 11481323; 11564735; 11744733; 12750254; 12446687; 11959990; 10700188

# Macromolecular_Interacting_Partner_29_References:
12840224; 15650166; 16456404

# Macromolecular_Interacting_Partner_30_ID:
7741

# Macromolecular_Interacting_Partner_30_Name:
Histone deacetylase 9

# Macromolecular_Interacting_Partner_30_Synonyms:
HD9; HD7B; HD7; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR

# Macromolecular_Interacting_Partner_30_Gene_Name:
HDAC9

# Macromolecular_Interacting_Partner_30_Protein_Sequence:
>Histone deacetylase 9
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK
EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA
ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS

# Macromolecular_Interacting_Partner_30_Number_of_Residues:
1011

# Macromolecular_Interacting_Partner_30_Molecular_Weight:
111298

# Macromolecular_Interacting_Partner_30_Theoretical_pI:
6.88

# Macromolecular_Interacting_Partner_30_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_30_General_Function:
Not Available

# Macromolecular_Interacting_Partner_30_Specific_Function:
Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter

# Macromolecular_Interacting_Partner_30_Pathway:
Not Available

# Macromolecular_Interacting_Partner_30_Reaction:
Not Available

# Macromolecular_Interacting_Partner_30_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_30_Signals:
None

# Macromolecular_Interacting_Partner_30_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_30_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_30_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_30_GenBank_ID_Protein:
15590680

# Macromolecular_Interacting_Partner_30_SwissProt_ID:
HDAC9_HUMAN (Q9UKV0)

# Macromolecular_Interacting_Partner_30_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_30_Genecard_id:
HDAC9

# Macromolecular_Interacting_Partner_30_Geneatlas_id:
HDAC9

# Macromolecular_Interacting_Partner_30_hgnc_id:
HGNC:14065

# Macromolecular_Interacting_Partner_30_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_30_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_30_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_30_Gene_Sequence:
>3036 bp
ATGCACAGTATGATCAGCTCAGTGGATGTGAAGTCAGAAGTTCCTGTGGGCCTGGAGCCC
ATCTCACCTTTAGACCTAAGGACAGACCTCAGGATGATGATGCCCGTGGTGGACCCTGTT
GTCCGTGAGAAGCAATTGCAGCAGGAATTACTTCTTATCCAGCAGCAGCAACAAATCCAG
AAGCAGCTTCTGATAGCAGAGTTTCAGAAACAGCATGAGAACTTGACACGGCAGCACCAG
GCTCAGCTTCAGGAGCATATCAAGGAACTTCTAGCCATAAAACAGCAACAAGAACTCCTA
GAAAAGGAGCAGAAACTGGAGCAGCAGAGGCAAGAACAGGAAGTAGAGAGGCATCGCAGA
GAACAGCAGCTTCCTCCTCTCAGAGGCAAAGATAGAGGACGAGAAAGGGCAGTGGCAAGT
ACAGAAGTAAAGCAGAAGCTTCAAGAGTTCCTACTGAGTAAATCAGCAACGAAAGACACT
CCAACTAATGGAAAAAATCATTCCGTGAGCCGCCATCCCAAGCTCTGGTACACGGCTGCC
CACCACACATCATTGGATCAAAGCTCTCCACCCCTTAGTGGAACATCTCCATCCTACAAG
TACACATTACCAGGAGCACAAGATGCAAAGGATGATTTCCCCCTTCGAAAAACTGCCTCT
GAGCCCAACTTGAAGGTGCGGTCCAGGTTAAAACAGAAAGTGGCAGAGAGGAGAAGCAGC
CCCTTACTCAGGCGGAAGGATGGAAATGTTGTCACTTCATTCAAGAAGCGAATGTTTGAG
GTGACAGAATCCTCAGTCAGTAGCAGTTCTCCAGGCTCTGGTCCCAGTTCACCAAACAAT
GGGCCAACTGGAAGTGTTACTGAAAATGAGACTTCGGTTTTGCCCCCTACCCCTCATGCC
GAGCAAATGGTTTCACAGCAACGCATTCTAATTCATGAAGATTCCATGAACCTGCTAAGT
CTTTATACCTCTCCTTCTTTGCCCAACATTACCTTGGGGCTTCCCGCAGTGCCATCCCAG
CTCAATGCTTCGAATTCACTCAAAGAAAAGCAGAAGTGTGAGACGCAGACGCTTAGGCAA
GGTGTTCCTCTGCCTGGGCAGTATGGAGGCAGCATCCCGGCATCTTCCAGCCACCCTCAT
GTTACTTTAGAGGGAAAGCCACCCAACAGCAGCCACCAGGCTCTCCTGCAGCATTTATTA
TTGAAAGAACAAATGCGACAGCAAAAGCTTCTTGTAGCTGGTGGAGTTCCCTTACATCCT
CAGTCTCCCTTGGCAACAAAAGAGAGAATTTCACCTGGCATTAGAGGTACCCACAAATTG
CCCCGTCACAGACCCCTGAACCGAACCCAGTCTGCACCTTTGCCTCAGAGCACGTTGGCT
CAGCTGGTCATTCAACAGCAACACCAGCAATTCTTGGAGAAGCAGAAGCAATACCAGCAG
CAGATCCACATGAACAAACTGCTTTCGAAATCTATTGAACAACTGAAGCAACCAGGCAGT
CACCTTGAGGAAGCAGAGGAAGAGCTTCAGGGGGACCAGGCGATGCAGGAAGACAGAGCG
CCCTCTAGTGGCAACAGCACTAGGAGCGACAGCAGTGCTTGTGTGGATGACACACTGGGA
CAAGTTGGGGCTGTGAAGGTCAAGGAGGAACCAGTGGACAGTGATGAAGATGCTCAGATC
CAGGAAATGGAATCTGGGGAGCAGGCTGCTTTTATGCAACAGCCTTTCCTGGAACCCACG
CACACACGTGCGCTCTCTGTGCGCCAAGCTCCGCTGGCTGCGGTTGGCATGGATGGATTA
GAGAAACACCGTCTCGTCTCCAGGACTCACTCTTCCCCTGCTGCCTCTGTTTTACCTCAC
CCAGCAATGGACCGCCCCCTCCAGCCTGGCTCTGCAACTGGAATTGCCTATGACCCCTTG
ATGCTGAAACACCAGTGCGTTTGTGGCAATTCCACCACCCACCCTGAGCATGCTGGACGA
ATACAGAGTATCTGGTCACGACTGCAAGAAACTGGGCTGCTAAATAAATGTGAGCGAATT
CAAGGTCGAAAAGCCAGCCTGGAGGAAATACAGCTTGTTCATTCTGAACATCACTCACTG
TTGTATGGCACCAACCCCCTGGACGGACAGAAGCTGGACCCCAGGATACTCCTAGGTGAT
GACTCTCAAAAGTTTTTTTCCTCATTACCTTGTGGTGGACTTGGGGTGGACAGTGACACC
ATTTGGAATGAGCTACACTCGTCCGGTGCTGCACGCATGGCTGTTGGCTGTGTCATCGAG
CTGGCTTCCAAAGTGGCCTCAGGAGAGCTGAAGAATGGGTTTGCTGTTGTGAGGCCCCCT
GGCCATCACGCTGAAGAATCCACAGCCATGGGGTTCTGCTTTTTTAATTCAGTTGCAATT
ACCGCCAAATACTTGAGAGACCAACTAAATATAAGCAAGATATTGATTGTAGATCTGGAT
GTTCACCATGGAAACGGTACCCAGCAGGCCTTTTATGCTGACCCCAGCATCCTGTACATT
TCACTCCATCGCTATGATGAAGGGAACTTTTTCCCTGGCAGTGGAGCCCCAAATGAGGTT
GGAACAGGCCTTGGAGAAGGGTACAATATAAATATTGCCTGGACAGGTGGCCTTGATCCT
CCCATGGGAGATGTTGAGTACCTTGAAGCATTCAGGACCATCGTGAAGCCTGTGGCCAAA
GAGTTTGATCCAGACATGGTCTTAGTATCTGCTGGATTTGATGCATTGGAAGGCCACACC
CCTCCTCTAGGAGGGTACAAAGTGACGGCAAAATGTTTTGGTCATTTGACGAAGCAATTG
ATGACATTGGCTGATGGACGTGTGGTGTTGGCTCTAGAAGGAGGACATGATCTCACAGCC
ATCTGTGATGCATCAGAAGCCTGTGTAAATGCCCTTCTAGGAAATGAGCTGGAGCCACTT
GCAGAAGATATTCTCCACCAAAGCCCGAATATGAATGCTGTTATTTCTTTACAGAAGATC
ATTGAAATTCAAAGTATGTCTTTAAAGTTCTCTTAA

# Macromolecular_Interacting_Partner_30_GenBank_ID_Gene:
AY032737

# Macromolecular_Interacting_Partner_30_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_30_Locus:
7p21.1

# Macromolecular_Interacting_Partner_30_SNPs:
rs1178127; rs17140166; rs34096894; rs2389998; rs35614472; rs7776735; rs7812296; rs706086; rs2526630; rs2074633; rs17139546; rs17348528; rs801524; rs17150251; rs2023938; rs2526631; rs957960; rs1178178; rs1178128; rs1726609; rs1178171; rs431; rs2188320; rs1178103; rs1178132; rs2028016; rs2695026; rs2520339; rs2588637; rs1178106; rs2520360; rs2520458; rs2520462; rs2073962; rs2588603; rs1178114; rs1178122; rs756789; rs212672; rs2519739; rs1178176; rs1629017; rs2073974; rs1034805; rs1178109; rs1726597; rs1726610; rs1178101; rs2106362; rs1178174; rs1178131; rs1557696; rs1178123; rs2588596; rs2257696; rs2016515; rs1178180; rs1018870; rs2588601; rs2519890; rs2588597; rs2588623; rs2073963; rs2520343; rs1548578; rs801540; rs2240281; rs212666; rs2853554; rs2189741; rs2588606; rs1178117; rs1178118; rs1178172; rs2526633; rs2023650; rs1178099; rs812395; rs2269923; rs1978191; rs1178111; rs723157; rs2526632; rs801541; rs1178164; rs2520355; rs2285431; rs212671; rs1178112; rs2106506; rs1726595; rs1178098; rs2526639; rs1726614; rs2588600; rs1011446; rs706087; rs1178165; rs2269924; rs2717351; rs1178179; rs2588635; rs9918514; rs12056043; rs6461396; rs6965278; rs1633789; rs6950979; rs2717342; rs801522; rs6948023; rs6461381; rs2269754; rs6967723; rs801539; rs2285438; rs2188321; rs726805; rs1615309; rs7788833; rs13438248; rs6461393; rs6954476; rs4721722; rs7807182; rs13241157; rs2285440; rs10276613; rs2023651; rs212664; rs2022090; rs2389995; rs813902; rs801767; rs768830; rs1859664; rs6954945; rs7806011; rs2519745; rs6969674; rs1076161; rs3901892; rs1178120; rs1178113; rs1633986; rs972400; rs801521; rs7456989; rs10272939; rs10268296; rs6946945; rs10250414; rs2526640; rs3213616; rs1178107; rs801760; rs2254993; rs4721717; rs10261942; rs1178119; rs3852257; rs801525; rs10280805; rs12533274; rs6951128; rs2286213; rs2389963; rs1178121; rs4721732; rs7779024; rs10281656; rs3852256; rs6461383; rs10252945; rs6979890; rs6972136; rs10228036; rs2390042; rs2157901; rs2588625; rs2717353; rs10272709; rs11765532; rs1178167; rs1178163; rs2239927; rs11983879; rs2249817; rs11977190; rs2695023; rs4721721; rs3852248; rs2717357; rs6965090; rs10268180; rs11767043; rs6461382; rs4721719; rs2269752; rs10271724; rs6952102; rs6461389; rs10950704; rs1918282; rs7808451; rs7794273; rs2528406; rs10269422; rs6963568; rs1178168; rs6980276; rs6977304; rs6461395; rs1178126; rs739457; rs2286003; rs7778211; rs2717356; rs2239926; rs7795433; rs6969316; rs7788972; rs1633779; rs7779555; rs4721720; rs2526641; rs6947529; rs10274006; rs10277631; rs7796939; rs6973063; rs1990115; rs957958; rs2073973; rs13230142; rs13241130; rs726116; rs6961943; rs2520348; rs10264011; rs6951522; rs2588633; rs1178102; rs7796078; rs2588605; rs801763; rs11505303; rs10274009; rs3852251; rs6979341; rs11764116; rs6461394; rs7798646; rs2190278; rs2254859; rs6950235; rs7809412; rs2588602; rs7808375; rs12535294; rs10223990; rs2526636; rs6968715; rs6959028; rs6973548; rs10237404; rs6951144; rs10226243; rs12540265; rs2695029; rs2066956; rs10486317; rs2214090; rs2717349; rs7787721; rs2285443; rs1178116; rs6461385; rs1178110; rs10253444; rs2269753; rs2853552; rs2520336; rs183325; rs801537; rs2528409; rs6967021; rs1476657; rs6461386; rs6950202; rs801758; rs1633987; rs4141402; rs11981267; rs10257046; rs10261390; rs3852253; rs2160543; rs1015407; rs756853; rs10266268; rs3807907; rs1178100; rs10225230; rs12056282; rs10237149; rs13245206; rs2073965; rs3910833; rs4721725; rs1554774; rs801519; rs10486318; rs1178170; rs2190276; rs7810384; rs4484585; rs2541318; rs6972607; rs7801849; rs801510; rs10237280; rs1178130; rs6960494; rs10227612; rs10280633; rs1726594; rs6962675; rs7811828; rs756790; rs11764843; rs1178108; rs801534; rs968842; rs10252839; rs13238389; rs6958865; rs2519889; rs6461384; rs11975297; rs10234134; rs2158768; rs2269748; rs2389992; rs2519746; rs10276724; rs3807917; rs4721729; rs4721715; rs3852254; rs2520345; rs6955959; rs6968777; rs3852255; rs17140345; rs10229723; rs10486293; rs11977090; rs12699984; rs10228341; rs10486323; rs17434924; rs2588627; rs9639321; rs17351069; rs17140251; rs6973918; rs10281987; rs17433319; rs2588609; rs7789752; rs2965026; rs1726602; rs10229062; rs17140423; rs11762171; rs6963748; rs17139975; rs17435661; rs1005139; rs12700005; rs10486312; rs2188495; rs1178143; rs1089358; rs13234273; rs10242218; rs9639319; rs1178105; rs801512; rs2588636; rs2588638; rs2520361; rs17140399; rs10282189; rs1633775; rs17139847; rs3807918; rs10278449; rs12670036; rs3814986; rs3823969; rs1918283; rs2024022; rs10486325; rs177080; rs10223954; rs10236906; rs7789378; rs10247238; rs12699985; rs801520; rs2520353; rs11761877; rs10282136; rs6949444; rs11973923; rs2704282; rs13231835; rs3807919; rs7811778; rs2285430; rs801516; rs12536081; rs1178155; rs11979779; rs2520358; rs2158495; rs1178156; rs10278707; rs10234485; rs13238305; rs17432977; rs6951745; rs9632592; rs1178177; rs1405618; rs3814985; rs1089357; rs6461392; rs2588599; rs1178129; rs1990116; rs7788731; rs17435702; rs801513; rs10249580; rs10245010; rs1633787; rs17432462; rs7782894; rs12700007; rs1624397; rs9648246; rs3814992; rs13243526; rs9655159; rs12536836; rs2301949; rs7802855; rs11972573; rs17139867; rs17140138; rs17350355; rs1178134; rs1726612; rs4721718; rs6967030; rs10265445; rs6977642; rs13231656; rs727851; rs3814993; rs2717339; rs10241099; rs6950598; rs13241957; rs3814989; rs6976460; rs10486330; rs12539715; rs13438582; rs2588604; rs929196; rs11977498; rs10266741; rs10242505; rs2519738; rs2157847; rs2520346; rs10245269; rs1178115; rs3757718; rs13232564; rs17140198; rs6972422; rs4141042; rs2285439; rs17139630; rs2588639; rs3852250; rs1178162; rs12669789; rs12535092; rs17150238; rs7808313; rs3887252; rs17349342; rs6974299; rs3807925; rs3864420; rs17139615; rs993082; rs11762829; rs7776786; rs17140017; rs10270954; rs3807909; rs11543651; rs7803715; rs11980610; rs10247184; rs4721726; rs10258770; rs7808621; rs801535; rs10270212; rs2520362; rs10254059; rs10253169; rs10486329; rs2519737; rs10249700; rs17139510; rs16872139; rs1178125; rs13241140; rs13221164; rs13234562; rs2704280; rs6954162; rs10259495; rs10246722; rs3901683; rs3910828; rs10486315; rs11982735; rs801768; rs1726596; rs2541321; rs3801986; rs11977467; rs12672843; rs11768780; rs2285442; rs10248565; rs17350236; rs2853556; rs9655161; rs6973029; rs2588634; rs1178166; rs1178148; rs11978963; rs3814991; rs2107596; rs12533489; rs7794241; rs10264621; rs3801985; rs10259213; rs6960766; rs10264832; rs10231651; rs11984282; rs2704281; rs17350431; rs2078869; rs6977299; rs17140193; rs2519891; rs1178133; rs706085; rs12669760; rs7807037; rs2240280; rs894978; rs2246313; rs11975390; rs17140170; rs17140363; rs10261308; rs3852252; rs6961395; rs3213615; rs7811991; rs2520354; rs10237366; rs10486314; rs4001107; rs2285437; rs17140086; rs10235067; rs10441039; rs10486310; rs10441038; rs12539764; rs2695027; rs4721728; rs1178160; rs3757717; rs11982970; rs7790924; rs968841; rs7801662; rs2240279; rs801508; rs3807922; rs12533452; rs3807920; rs17349860; rs2073964; rs12699995; rs6959501; rs1178150; rs7798677; rs801514; rs17140374; rs6956139; rs1089359; rs12113191; rs17139769; rs17432448; rs13246896; rs10486289; rs4721716; rs17139504; rs17350383; rs2519740; rs17349622; rs17140133; rs10243224; rs717982; rs11980192; rs12540774; rs13227668; rs801759; rs7788734; rs3757716; rs4445123; rs17140258; rs17140158; rs1178159; rs801523; rs10245874; rs10243888; rs3801983; rs10277107; rs9639320; rs6461387; rs801515; rs17139817; rs2717344; rs6461390; rs12540224; rs1178144; rs17139557; rs2301950; rs17139857; rs11984041; rs2078866; rs17139842; rs12699996; rs12700009; rs7783171; rs2190277; rs10224196; rs10486327; rs11975907; rs2520352; rs6461397; rs12531908; rs6950376; rs801511; rs4721723; rs3807901; rs11505418; rs1178149; rs2520460; rs17150249; rs10272295; rs17139913; rs11982807; rs169871; rs13233322; rs17139283; rs11982615; rs10258269; rs2704283; rs17139704; rs7789723; rs2588622; rs2188322; rs212665; rs10231336; rs10486292; rs17139544; rs6974604; rs17139278; rs17139316; rs1405615; rs1079954; rs1178142; rs10235695; rs10950705; rs4605958; rs17140418; rs1178169; rs6952297; rs7801553; rs6947318; rs10247766; rs2965027; rs2214850; rs2285433; rs10248443; rs2028013; rs13238221; rs17139763; rs10270210; rs801526; rs7780629; rs13238702; rs2519744; rs17350515; rs801538; rs17350397; rs7780397; rs11980989; rs2520359; rs7459007; rs2285436; rs10230491; rs2240419; rs17433123; rs17139344; rs10241929; rs2520351; rs13224833; rs2520344; rs10215410; rs1918284; rs7803518; rs2588628; rs10240305; rs2704289; rs10244193; rs17139516; rs1980368; rs6651064; rs6956490; rs6950420; rs12539449; rs2190275; rs212670; rs7801037; rs10228382; rs17139854; rs17140253; rs17139840; rs801517; rs2240278; rs9918521; rs12700010; rs7808698; rs3854289; rs10251998; rs13238035; rs801530; rs2853557; rs10274126; rs2157900; rs17350341; rs6974011; rs2526637; rs2190273; rs11763653; rs12669473; rs17435730; rs212663; rs10253478; rs7779171; rs17433095; rs2965029; rs2588607; rs10260390; rs10237177; rs17139789; rs10247256; rs2028014; rs17139571; rs12672635; rs2285435; rs17139365; rs11983126; rs801761; rs12539747; rs7777856; rs17150253; rs10265632; rs13224263; rs801507; rs11973076; rs2520457; rs10263618; rs1633791; rs17139554; rs2389997; rs17139508; rs10243892; rs212669; rs2704284; rs1182736; rs10277165; rs7455344; rs7780101; rs2520349; rs7803235; rs4721734; rs6968894; rs212673; rs12700012; rs2190274; rs2588631; rs10266607; rs13234557; rs2717352; rs212662; rs16872155; rs10261429; rs1405616; rs10281362; rs6955566; rs17139401; rs17350229; rs10251867; rs7781098; rs17139451; rs10276216; rs10272517; rs10236109; rs10486316; rs11982882; rs17139861; rs17140014; rs7793637; rs3823968; rs17139947; rs2520456; rs7455862; rs10253041; rs17348617; rs10224035; rs17139610; rs7785029; rs2285432; rs10240266; rs12113679; rs10224678; rs12700001; rs2526638; rs7784004; rs1178146; rs17140022; rs7455192; rs10237427; rs10253117; rs17150245; rs17139396; rs10266064; rs7789450; rs7806036; rs17432782; rs10215908; rs1178158; rs2520341; rs10273908; rs17139658; rs12700011; rs10252281; rs10267406; rs3807915; rs17140010; rs7780546; rs3814990; rs1554772; rs7780396; rs10225036; rs1178173; rs2541323; rs17139921; rs10244908; rs1554771; rs2839834; rs5011547; rs212674; rs7785216; rs706084; rs756854; rs11970952; rs17139319; rs1178124; rs10224266; rs2541316; rs2695028; rs6968045; rs212661; rs13235810; rs17349832; rs10232282; rs993083; rs2892905; rs801533; rs4721735; rs12056184; rs1117533; rs2717348; rs2243880; rs6946788; rs35827444; rs17139894; rs12668871; rs1405619; rs13229874; rs17140333; rs2520335; rs2520357; rs17140244; rs12699981; rs10256595; rs10247255; rs2308213; rs2588612; rs10241000; rs17140431; rs6944365; rs2541322; rs11973986; rs12700014; rs10268558; rs17433270; rs7804088; rs17139280; rs1726599; rs6958814; rs10235392; rs7780385; rs10263220; rs2853555; rs3901982; rs12699982; rs1989817; rs3852249; rs10251026; rs17140220; rs17140286; rs212668; rs12540872; rs7780668; rs801532; rs17139758; rs12530943; rs12530952; rs17139619; rs1726600; rs12539229; rs10234685; rs6955855; rs17139311; rs10261637; rs12171607; rs7799557; rs4413678; rs17140387; rs11765005; rs17140104; rs10242336; rs11977303; rs801529; rs7798921; rs1178147; rs6972767; rs7799349; rs12530969; rs10241413; rs3855596; rs10245511; rs7795954; rs12699991; rs7789261; rs10264800; rs6651065; rs2028015; rs2717358; rs10234468; rs2158494; rs2078867; rs2520337; rs10237624; rs6951973; rs7784812; rs11766784; rs10252543; rs12699983; rs10248070; rs10267142; rs2440598; rs801528; rs6461391; rs2717350; rs6973675; rs1178152; rs1405617; rs12700004; rs11974250; rs13239610; rs1726601; rs17139896; rs7777331; rs10249862; rs801765; rs10486291; rs2520363; rs2588621; rs13244868; rs7802878; rs4379363; rs2519747; rs7812153; rs801527; rs11973990; rs17140227; rs2024021; rs12535768; rs10281075; rs16872067; rs12539815; rs9886098; rs11978418; rs10230426; rs3807921; rs17140149; rs10249414; rs1918285; rs7782319; rs13239638; rs13237090; rs212667; rs17139675; rs10046476; rs7783209; rs212675; rs2028012; rs11970990; rs2519741; rs17139560; rs17140237; rs3757720; rs2023937; rs17347842; rs35691757; rs4607511; rs34282407; rs35409100; rs4391313; rs35201317; rs11459782; rs28368369; rs34279008; rs35157147; rs13233302; rs17150262; rs7786280; rs13228422; rs34931172; rs4719537; rs13229726; rs34720287; rs10716963; rs11767940; rs2588630; rs2204605; rs3841499; rs28559740; rs35497056; rs1527274; rs13225984; rs28634669; rs34163887; rs28711567; rs10707338; rs6961101; rs4721736; rs801764; rs801518; rs10614926; rs13242358; rs5882665; rs12699994; rs12056180; rs35444683; rs35812044; rs11308716; rs11337572; rs5882663; rs13312243; rs35203023; rs5882685; rs13240439; rs13227230; rs13235616; rs34082340; rs35959076; rs13230679; rs6978417; rs13240422; rs2965025; rs28463874; rs34482909; rs2158496; rs34388101; rs2520350; rs6969976; rs35330871; rs36047664; rs2588629; rs3891716; rs12539329; rs28636374; rs1178154; rs5882664; rs6947860; rs34409566; rs2588594; rs4043163; rs35016592; rs6959575; rs35967730; rs34574212; rs35576834; rs34956033; rs3216880; rs34309365; rs10280899; rs17139681; rs35812862; rs10224204; rs1178157; rs28379904; rs35296958; rs12539039; rs2301590; rs28477889; rs34605906; rs35094737; rs36039150; rs11451343; rs35351061; rs35933646; rs12699997; rs7458572; rs34511470; rs6461388; rs35278511; rs35255822; rs4043674; rs3840627; rs13235779; rs34633937; rs2695025; rs10156052; rs35248186; rs11418791; rs3085465; rs10245469; rs13240430; rs34797020; rs35092939; rs2301591; rs3084516; rs1527273; rs7807789; rs28600831; rs35229257; rs1980367; rs34240713; rs28636957; rs35711806; rs6946247; rs6952629; rs13239807; rs34787008; rs35994068; rs28562712; rs35848123; rs2717343; rs1726584; rs10229559; rs13225057; rs35993578; rs34688000; rs34979997; rs34196671; rs34341332; rs4719542; rs35678026; rs34977439; rs2588595; rs35752679; rs6969022; rs4719536; rs12154657; rs35924732; rs12700006; rs11388709; rs13222827; rs34162765; rs3854290; rs801509; rs4721737; rs12530778; rs35277570; rs2520461; rs28824774; rs36021638; rs28465160; rs2704295; rs2389994; rs35187226; rs2704292; rs10264358; rs35449622; rs3214108; rs34149953; rs6980191; rs35024729; rs35895317; rs35305527; rs34667664; rs13222822; rs10215803; rs34716480; rs34432130; rs34924821; rs12537096; rs34302776; rs36198663; rs13235460; rs35870846; rs34385627; rs35057182; rs1178153; rs2520347; rs11381401; rs13227916; rs35936891; rs5882679; rs35315535; rs35112564; rs1858903; rs12672380; rs34857064; rs3214116; rs717983; rs13243554; rs35587017; rs7458543; rs12671114; rs28497492; rs35454576; rs10277147; rs5882667; rs10253557; rs35340229; rs41273072; rs2526642; rs7795948; rs10261268; rs10268544; rs13226687; rs1476472; rs10671468; rs34262506; rs35296026; rs10275404; rs4043672; rs801531; rs5882676; rs5882682; rs35213806; rs2528407; rs28653029; rs28651961; rs34279083; rs1178140; rs2704286; rs34580817; rs6955525; rs3757719; rs28562781; rs1178104; rs17140231; rs4620175; rs4001106; rs35144869; rs34569140; rs12700000; rs28712504; rs34410437; rs36198766; rs35089454; rs34719027; rs34872310; rs2078868; rs35912823; rs5882680; rs34790980; rs5882690; rs10553612; rs5882687; rs34174659; rs10262002; rs13239170; rs35493266; rs35905914; rs28507946; rs10233694; rs28412143; rs35728273; rs36120359; rs28726229; rs34371333; rs36126241; rs4719535; rs13231902; rs35636834; rs1306444; rs34205559; rs35930688; rs4043670; rs10664010; rs35895810; rs36199570; rs212676; rs34366508; rs34618311; rs28562391; rs35041323; rs35437686; rs10226794; rs35499273; rs35692319; rs11767937; rs41273069; rs2588632; rs34379636; rs1178175; rs11327408; rs13238200; rs35689821; rs5882681; rs13231903; rs3084518; rs2588619; rs35622841; rs10713737; rs2157848; rs1726604; rs28597795; rs34800999; rs35536634; rs4573147; rs13241772; rs801766; rs35334608; rs11308990; rs11768313; rs10252885; rs13238092; rs34018423; rs10606383; rs35729003; rs34954969; rs2520364; rs2248166; rs34314311; rs35457342; rs2519743; rs34285752; rs28684496; rs8180760; rs3815193; rs34609070; rs35648258; rs4721727; rs1527275; rs35841351; rs3214216; rs2704290; rs34751779; rs13241874; rs5882666; rs4719538; rs34155355; rs28558591; rs6957711; rs35317563; rs36047659; rs3084722; rs28615740; rs13225982; rs4001105; rs35112815; rs28418568; rs35952151; rs34367677; rs10607388; rs10583381; rs1060644; rs12539520; rs34371245; rs10233651; rs3807898; rs13222773; rs169870; rs7776647; rs35354025; rs28436911; rs36109077; rs34326798; rs34165296; rs28444384; rs34209277; rs35274626; rs10667801; rs13239127; rs28464929; rs10599852; rs11394184; rs10613485; rs12699999; rs6966621; rs2695031; rs35113543; rs13243833; rs2704296; rs36219354; rs34559757; rs33953087; rs35271883; rs35839657; rs13244490; rs34707237; rs11306117; rs34574947; rs2588626; rs11443603; rs5882677; rs10573875; rs13241885; rs34383618; rs35476249; rs36036184; rs34620445; rs13223938; rs10561154; rs2520356; rs34236489; rs34790628; rs13231200; rs35242513; rs34258165; rs35922999; rs10276963; rs2695024; rs11298745; rs2389996; rs28490273; rs35824820; rs2588598; rs35807742; rs11982154; rs35240820; rs34065924; rs1726615; rs11768078; rs2717355; rs3216876; rs7797355; rs28565563; rs10275158; rs34349667; rs5022872; rs5882670; rs2269750; rs2520455; rs35673681; rs28558159; rs13239128; rs35623543; rs10580938; rs1125817; rs28465488; rs28413528; rs2704288; rs28459126; rs35753491; rs10274167; rs6150011; rs34173167; rs11976337; rs11351795; rs10566836; rs34376401; rs2695030; rs34685546; rs10275151; rs809045; rs10272035; rs13241480; rs10644628; rs10441036; rs34821051; rs34556374; rs35080681; rs1980366; rs34739935; rs3807924; rs11381062; rs2526635; rs1178137; rs13222762; rs2057821; rs11423578; rs34521762; rs34895513; rs7809331; rs2519742; rs28754411; rs35286474; rs13235348; rs35422354; rs6948613; rs4496866; rs36014102; rs35422133; rs34906576; rs957959; rs1527271; rs5882674; rs36075894; rs13245836; rs10696918; rs35167925; rs13310387; rs1622717; rs28633468; rs28709047; rs2520342; rs2853553; rs35056400; rs35820479; rs35338088; rs12539967; rs35977400; rs13230346; rs10587630; rs35147513; rs36100341; rs10252814; rs11352528; rs7797015; rs17140088; rs6150012; rs2106361; rs13308348; rs36050256; rs34512827; rs13224579; rs10243449; rs4478470; rs6974492; rs34594276; rs35353333; rs10280885; rs34032729; rs35378236; rs2965028; rs2301589; rs34921121; rs11543622; rs35526519; rs2717354; rs2051923; rs28587220; rs28539032; rs28498417; rs35458239; rs28459772; rs801762; rs11979465; rs12700002; rs769132; rs35706134; rs35767316; rs16872130; rs11410404; rs10246593; rs28652749; rs17139823; rs10275157; rs35015098; rs36216270; rs2695021; rs3857710; rs3807910; rs34987742; rs12055954; rs35185507; rs35857025; rs34048515; rs35599939; rs34114749; rs34646502; rs801536; rs2541320; rs5882675; rs172476; rs2695022; rs2285434; rs2704285; rs11348285; rs35779976; rs2588613; rs13228428; rs10230466; rs28410682; rs2588624; rs34814015; rs35528531; rs35426279; rs11385376; rs10573876; rs34896059; rs28811631; rs10567506; rs5882684; rs34805240; rs5882668; rs35289984; rs28631781; rs13242758; rs2853558; rs3807923; rs35088007; rs3214109; rs212677; rs35107667; rs28690889; rs1978072; rs34687639; rs11765209; rs28520008; rs35573809; rs10280856; rs13231304; rs34449742; rs2389999; rs12700003; rs34451381; rs28674699; rs3216881; rs36107809; rs1633982; rs34967225; rs28759229; rs34825618; rs34910827; rs13222043; rs34701409; rs10269572; rs10678670; rs13246595; rs28571726; rs6958369; rs34699073; rs28697972; rs11388242; rs10226245; rs35586562; rs34999300; rs2389993; rs10245337; rs11312304; rs34710369; rs34592963; rs12699998; rs1178139; rs6952549; rs34052960; rs35414332; rs12672415; rs2695020; rs35048169; rs1012658; rs35714495; rs2704297; rs6978681; rs33919260; rs1974489; rs13238644; rs2390041; rs4721738; rs2704291; rs28694625; rs34271373; rs35126547; rs34239413; rs28447433; rs41273075; rs10253743; rs28700157; rs3807916; rs35450308; rs5882672; rs28630018; rs28475856; rs28550369; rs2269747; rs28712749; rs2073975; rs4379362; rs6946886; rs10281766; rs12532942; rs5882673; rs34293829; rs3214107; rs28419057; rs41273078; rs35215030; rs36107669; rs13226069; rs34488992; rs35667102; rs17140226; rs36087105; rs34010659; rs28421316; rs10224198; rs2520340; rs11505416; rs10241581; rs13222764; rs11332205; rs10256357; rs1054178; rs2526634; rs3085467; rs28489181; rs16872149; rs13235453; rs3084755; rs5882683; rs4560704; rs1726608; rs1178222; rs3085431; rs6974469; rs28628267; rs13235553; rs28767930; rs35211946; rs35997540; rs35351919; rs7790376; rs17139884; rs5007139; rs17139923; rs13309163; rs35677313; rs1178138; rs35194159; rs2528408; rs1178141; rs35536284; rs36199448; rs28739368; rs5882671; rs34307478; rs13310264; rs34899469; rs34738573; rs2389927; rs1859663; rs34885265; rs10282165; rs3807908; rs13228580; rs36203178; rs12700013; rs11325618; rs36106556; rs1178151; rs3844320; rs34776880; rs11412900; rs2269751; rs751185; rs6951519; rs36074895; rs34854568; rs12055896; rs2906046; rs13239802; rs7458544; rs1633790; rs34358745; rs34840095; rs35395539; rs1178135; rs34025201; rs801757; rs9655160; rs11364088; rs1633993; rs10235499; rs34635798; rs35521033; rs10228641; rs34098679; rs1962774; rs36198668; rs10254903; rs12536615; rs10281822; rs10230371; rs35374719; rs10580574; rs5022871; rs10046581; rs35930288; rs35145987; rs28401174; rs1527272; rs1178136; rs10244626; rs10225951; rs35074349; rs10605389; rs11357950; rs35157772; rs4590333; rs10240128; rs35285583; rs35788528; rs34875036; rs2023652; rs5882686; rs1726585; rs13310129; rs34392281; rs12055953; rs11347832; rs35803639; rs34038989; rs10950703; rs6945057; rs34905635; rs13347372; rs10275281; rs5882669; rs34701084; rs2285441; rs4721724; rs2519725; rs34474069; rs11531457; rs34910054; rs10241753; rs10241964; rs10245779; rs10266369; rs13225078; rs13247382; rs2023936; rs2051920; rs2158493; rs2526619; rs2526621; rs2526622; rs2526623; rs2526624; rs2526625; rs2526626; rs2526627; rs2526629; rs2717346; rs4266547; rs432; rs433; rs434; rs7792656; rs7798197; rs7807970

# Macromolecular_Interacting_Partner_30_General_References:
11535832; 12706107; 12590135; 9872452; 12853948; 10523670; 10487760; 10487761; 12032081

# Macromolecular_Interacting_Partner_30_References:
12840228; 14750171; 14989149; 15093136

# Macromolecular_Interacting_Partner_31_ID:
8462

# Macromolecular_Interacting_Partner_31_Name:
Leukocyte antigen

# Macromolecular_Interacting_Partner_31_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Name:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_Protein_Sequence:
>Leukocyte antigen
RFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQK
DILEQARAAVDTYCRHNYGAVESFTVQRR

# Macromolecular_Interacting_Partner_31_Number_of_Residues:
89

# Macromolecular_Interacting_Partner_31_Molecular_Weight:
10771

# Macromolecular_Interacting_Partner_31_Theoretical_pI:
5.17

# Macromolecular_Interacting_Partner_31_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_31_General_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_31_Pathway:
Not Available

# Macromolecular_Interacting_Partner_31_Reaction:
Not Available

# Macromolecular_Interacting_Partner_31_Pfam_Domain_Function:
PF00969:MHC_II_beta

# Macromolecular_Interacting_Partner_31_Signals:
None

# Macromolecular_Interacting_Partner_31_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_31_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_31_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_31_GenBank_ID_Protein:
1914731

# Macromolecular_Interacting_Partner_31_SwissProt_ID:
O00157_HUMAN (O00157)

# Macromolecular_Interacting_Partner_31_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_31_Genecard_id:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_Geneatlas_id:
HLA-DRB5new

# Macromolecular_Interacting_Partner_31_hgnc_id:
HGNC:4953

# Macromolecular_Interacting_Partner_31_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_31_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_31_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Gene_Sequence:
>269 bp
CACGTTTCTTGCAGCAGGATAAGTATGAGTGTCATTTCTTCAACGGGACGGAGCGGGTGC
GGTTCCTGCACAGAGACATCTATAACCAAGAGGAGGACTTGCGCTTCGACAGCGACGTGG
GGGAGTACCGGGCGGTGACGGAGCTGGGGCGGCCTGACGCTGAGTACTGGAACAGCCAGA
AGGACATCCTGGAGCAGGCGCGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGG
CTGTGGAGAGCTTCACAGTGCAGCGGCGA

# Macromolecular_Interacting_Partner_31_GenBank_ID_Gene:
Z83201

# Macromolecular_Interacting_Partner_31_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_31_Locus:
Not Available

# Macromolecular_Interacting_Partner_31_SNPs:
Not Available

# Macromolecular_Interacting_Partner_31_General_References:
9226128

# Macromolecular_Interacting_Partner_31_References:
15142888; 15208660

# Macromolecular_Interacting_Partner_32_ID:
7975

# Macromolecular_Interacting_Partner_32_Name:
Tyrosine 3-monooxygenase

# Macromolecular_Interacting_Partner_32_Synonyms:
Tyrosine 3-hydroxylase; TH

# Macromolecular_Interacting_Partner_32_Gene_Name:
TH

# Macromolecular_Interacting_Partner_32_Protein_Sequence:
>Tyrosine 3monooxygenase
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

# Macromolecular_Interacting_Partner_32_Number_of_Residues:
528

# Macromolecular_Interacting_Partner_32_Molecular_Weight:
58525

# Macromolecular_Interacting_Partner_32_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_32_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Function:  tyrosine 3-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  catecholamine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aromatic amino acid family metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_32_General_Function:
Amino acid transport and metabolism 

# Macromolecular_Interacting_Partner_32_Specific_Function:
Plays an important role in the physiology of adrenergic neurons

# Macromolecular_Interacting_Partner_32_Pathway:
map00350  Tyrosine metabolism

# Macromolecular_Interacting_Partner_32_Reaction:
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

# Macromolecular_Interacting_Partner_32_Pfam_Domain_Function:
PF00351:Biopterin_H

# Macromolecular_Interacting_Partner_32_Signals:
None

# Macromolecular_Interacting_Partner_32_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_32_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_32_EC_Link:
EC 1.14.16.2

# Macromolecular_Interacting_Partner_32_GenBank_ID_Protein:
37127

# Macromolecular_Interacting_Partner_32_SwissProt_ID:
TY3H_HUMAN (P07101)

# Macromolecular_Interacting_Partner_32_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_32_Genecard_id:
TH

# Macromolecular_Interacting_Partner_32_Geneatlas_id:
TH

# Macromolecular_Interacting_Partner_32_hgnc_id:
HGNC:11782

# Macromolecular_Interacting_Partner_32_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_32_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_32_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_32_Gene_Sequence:
>1575 bp
ATGCCCACCCCCGACGCCACCACGCCACAGGCCAAGGGCTTCCGCAGGGCCGTGTCTGAG
CTGGACGCCAAGCAGGCAGAGGCCATCATGGGCGCCCCGGGGCCCAGCCTCACAGGCTCT
CCGTGGCCTGGAACTGCAGCCCCAGCTGCATCCTACACCCCCACCCCAAGGTCCCCGCGG
TTCATTGGGCGCAGGCAGAGCCTCATCGAGGACGCCCGCAAGGAGCGGGAGGCGGCGGTG
GCAGCAGCGGCCGCTGCAGTCCCCTCGGAGCCCGGGGACCCCCTGGAGGCTGTGGCCTTT
GAGGAGAAGGAGGGGAAGGCCGTGCTAAACCTGCTCTTCTCCCCGAGGGCCACCAAGCCC
TCGGCGCTGTCCCGAGCTGTGAAGGTGTTTGAGACGTTTGAAGCCAAAATCCACCATCTA
GAGACCCGGCCCGCCCAGAGGCCGCGAGCTGGGGGCCCCCACCTGGAGTACTTCGTGCGC
CTCGAGGTGCGCCGAGGGGACCTGGCCGCCCTGCTCAGTGGTGTGCGCCAGGTGTCAGAG
GACGTGCGCAGCCCCGCGGGGCCCAAGGTCCCCTGGTTCCCAAGAAAAGTGTCAGAGCTG
GACAAGTGTCATCACCTGGTCACCAAGTTCGACCCTGACCTGGACTTGGACCACCCGGGC
TTCTCGGACCAGGTGTACCGCCAGCGCAGGAAGCTGATTGCTGAGATCGCCTTCCAGTAC
AGGCACGGCGACCCGATTCCCCGTGTGGAGTACACCGCCGAGGAGATTGCCACCTGGAAG
GAGGTCTACACCACGCTGAAGGGCCTCTACGCCACGCACGCCTGCGGGGAGCACCTGGAG
GCCTTTGCTTTGCTGGAGCGCTTCAGCGGCTACCGGGAAGACAATATCCCCCAGCTGGAG
GACGTCTCCCGCTTCCTGAAGGAGCGCACGGGCTTCCAGCTGCGGCCTGTGGCCGGCCTG
CTGTCCGCCCGGGACTTCCTGGCCAGCCTGGCCTTCCGCGTGTTCCAGTGCACCCAGTAT
ATCCGCCACGCGTCCTCGCCCATGCACTCCCCTGAGCCGGACTGCTGCCACGAGCTGCTG
GGGCACGTGCCCATGCTGGCCGACCGCACCTTCGCGCAGTTCTCGCAGGACATTGGCCTG
GCGTCCCTGGGGGCCTCGGATGAGGAAATTGAGAAGCTGTCCACGCTGTCATGGTTCACG
GTGGAGTTCGGGCTGTGTAAGCAGAACGGGGAGGTGAAGGCCTATGGTGCCGGGCTGCTG
TCCTCCTACGGGGAGCTCCTGCACTGCCTGTCTGAGGAGCCTGAGATTCGGGCCTTCGAC
CCTGAGGCTGCGGCCGTGCAGCCCTACCAAGACCAGACGTACCAGTCAGTCTACTTCGTG
TCTGAGAGCTTCAGTGACGCCAAGGACAAGCTCAGGAGCTATGCCTCACGCATCCAGCGC
CCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACGTGCTGGACAGCCCCCAG
GCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACACCCTTGCCCATGCGCTG
AGTGCCATTGGCTAG

# Macromolecular_Interacting_Partner_32_GenBank_ID_Gene:
Y00414

# Macromolecular_Interacting_Partner_32_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_32_Locus:
11p15.5

# Macromolecular_Interacting_Partner_32_SNPs:
rs6356; rs7950050; rs6357; rs34510659; rs11826260; rs3842725; rs10840489; rs11825601; rs4074905; rs12419447; rs2070762; rs7482510; rs3842722; rs7925924; rs7942881; rs11826130; rs7483805; rs7483056; rs4072826; rs4072824; rs7925375; rs7479936; rs4072823; rs3842723; rs10743149; rs10770140; rs3842727; rs7119275; rs7115640; rs10840490; rs10770141; rs11564711; rs10840491; rs3842726; rs11042962; rs10770142; rs28934581; rs28934579; rs28934580; rs1800033; rs36097848; rs3842724; rs1799833; rs11564716; rs34723540; rs6578990; rs11042950; rs3842721; rs35596265; rs11564713; rs11564712; rs36009557; rs4930043; rs36010304; rs7925784; rs35996457; rs4072825; rs35125951; rs11564714; rs35444567; rs34965351; rs11564715; rs11564717; rs10734659; rs11564718; rs1800032; rs10743152; rs10770143; rs10840447; rs10840452; rs10840495; rs10840496; rs10840502; rs11042965; rs11042966; rs11042971; rs11042976; rs11042978; rs11042982; rs11042984; rs11042987; rs11564709; rs11564710; rs11564720; rs2000993; rs28494588; rs28933985; rs3842733; rs3842738; rs3842741; rs3842748; rs3842752; rs3842753; rs3842754; rs3842756; rs3842768; rs3842769; rs3842770; rs3842775; rs4929964; rs4929966; rs4930046; rs5505; rs5506; rs5507; rs6578993; rs689; rs7110099; rs7128097; rs7482891; rs7936868

# Macromolecular_Interacting_Partner_32_General_References:
2882428; 2888085; 2887169; 2902075; 2892893; 2896667; 7814018; 7789962; 8528210; 8817341; 9613851; 9754624; 9703425; 10391209; 11246459

# Macromolecular_Interacting_Partner_32_References:
14739357; 16165221

# Macromolecular_Interacting_Partner_33_ID:
8381

# Macromolecular_Interacting_Partner_33_Name:
Myc proto-oncogene protein

# Macromolecular_Interacting_Partner_33_Synonyms:
c-Myc; Transcription factor p64

# Macromolecular_Interacting_Partner_33_Gene_Name:
MYC

# Macromolecular_Interacting_Partner_33_Protein_Sequence:
>Myc protooncogene protein
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPP
LSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPD
DETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQD
LSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVL
HEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRC
HVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHN
VLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLL
RKRREQLKHKLEQLRNSCA

# Macromolecular_Interacting_Partner_33_Number_of_Residues:
439

# Macromolecular_Interacting_Partner_33_Molecular_Weight:
48804

# Macromolecular_Interacting_Partner_33_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_33_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  transcription factor activity
Function:  transcription regulator activity
 ||
>>>
Process:  regulation of transcription, DNA-dependent
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_33_General_Function:
Not Available

# Macromolecular_Interacting_Partner_33_Specific_Function:
Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes

# Macromolecular_Interacting_Partner_33_Pathway:
Not Available

# Macromolecular_Interacting_Partner_33_Reaction:
Not Available

# Macromolecular_Interacting_Partner_33_Pfam_Domain_Function:
PF00010:HLH;
PF02344:Myc-LZ;
PF01056:Myc_N

# Macromolecular_Interacting_Partner_33_Signals:
None

# Macromolecular_Interacting_Partner_33_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_33_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_33_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_33_SwissProt_ID:
MYC_HUMAN (P01106)

# Macromolecular_Interacting_Partner_33_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_33_Genecard_id:
MYC

# Macromolecular_Interacting_Partner_33_Geneatlas_id:
MYC

# Macromolecular_Interacting_Partner_33_hgnc_id:
HGNC:7553

# Macromolecular_Interacting_Partner_33_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_33_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_33_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_33_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_33_GenBank_ID_Gene:
D10493

# Macromolecular_Interacting_Partner_33_Chromosome_Location:
Chromosome:8

# Macromolecular_Interacting_Partner_33_Locus:
8q24.12-q24.13

# Macromolecular_Interacting_Partner_33_SNPs:
rs4645961; rs4645959; rs4645968; rs4645960; rs4645969; rs2070582; rs2070583; rs4645970; rs35524866; rs4645955; rs3891248; rs4645966; rs4645962; rs4645956; rs4645958; rs4645967; rs10110283; rs4645963; rs4645957; rs4645954; rs28933407; rs14607; rs34219247; rs35291508; rs4645953; rs35168393; rs35015903; rs4645964; rs4645965; rs35084990; rs10706841; rs10706840; rs5894898; rs34682115; rs4645971; rs35631115; rs10108288; rs10505505; rs10956383; rs11782002; rs12680047; rs16902359; rs16902364; rs16902387; rs17187428; rs17773712; rs2071346; rs3808379; rs3824120; rs3895617; rs4645940; rs4645941; rs4645943; rs4645945; rs4645946; rs4645947; rs4645948; rs4645950; rs4645951; rs4645972; rs4645973; rs4645974; rs4645975; rs4733550; rs7003472; rs7013527; rs7462301; rs7818443

# Macromolecular_Interacting_Partner_33_General_References:
6714223; 6298632; 6304538; 6321164; 6419122; 6414718; 6304729; 6547209; 3540591; 8386367; 7642555; 9315742; 9680483

# Macromolecular_Interacting_Partner_33_References:
14568568; 15713675

# Macromolecular_Interacting_Partner_34_ID:
8444

# Macromolecular_Interacting_Partner_34_Name:
Transforming growth factor beta-1 precursor

# Macromolecular_Interacting_Partner_34_Synonyms:
TGF-beta-1[Contains: Latency-associated peptide; LAP]

# Macromolecular_Interacting_Partner_34_Gene_Name:
TGFB1

# Macromolecular_Interacting_Partner_34_Protein_Sequence:
>Transforming growth factor beta1 precursor
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

# Macromolecular_Interacting_Partner_34_Number_of_Residues:
390

# Macromolecular_Interacting_Partner_34_Molecular_Weight:
44342

# Macromolecular_Interacting_Partner_34_Theoretical_pI:
8.63

# Macromolecular_Interacting_Partner_34_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  transforming growth factor beta receptor binding
 ||
>>>
Process:  growth
Process:  cell growth
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_34_General_Function:
Not Available

# Macromolecular_Interacting_Partner_34_Specific_Function:
Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodelling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts

# Macromolecular_Interacting_Partner_34_Pathway:
Not Available

# Macromolecular_Interacting_Partner_34_Reaction:
Not Available

# Macromolecular_Interacting_Partner_34_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_34_Signals:
1-29

# Macromolecular_Interacting_Partner_34_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_34_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_34_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_34_GenBank_ID_Protein:
1212989

# Macromolecular_Interacting_Partner_34_SwissProt_ID:
TGFB1_HUMAN (P01137)

# Macromolecular_Interacting_Partner_34_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_34_Genecard_id:
TGFB1

# Macromolecular_Interacting_Partner_34_Geneatlas_id:
TGFB1

# Macromolecular_Interacting_Partner_34_hgnc_id:
HGNC:11766

# Macromolecular_Interacting_Partner_34_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_34_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_34_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_34_Gene_Sequence:
>355 bp
ATGCCGCCCTCCGGGCTGCGGCTGCTGCTGCTGCTGCTACCGCTGCTGTGGCTACTGGTG
CTGACGCCTGGCCGGCCGGCCGCGGGACTATCCACCTGCAAGACTATCGACATGGAGCTG
GTGAAGCGGAAGCGCATCGAGGCCATCCGCGGCCAGATCCTGTCCAAGCTGCGGCTCGCC
AGCCCCCCGAGCCAGGGGGAGGTGCCGCCCGGCCCGCTGCCCGAGGCCGTGCTCGCCCTG
TACAACAGCACCCGCGACCGGGTGGCCGGGGAGAGTGCAGAACCGGAGCCCGAGCCTGAG
GCCGACTACTACGCCAAGGAGGTCACCCGCGTGCTAATGGTGGAAACCCACAACG

# Macromolecular_Interacting_Partner_34_GenBank_ID_Gene:
X05839

# Macromolecular_Interacting_Partner_34_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_34_Locus:
19q13.2|19q13.1

# Macromolecular_Interacting_Partner_34_SNPs:
rs1982073; rs1800472; rs1800471; rs9282871; rs11466316; rs11466315; rs2241717; rs7408955; rs2278422; rs13306709; rs7258445; rs2288873; rs747857; rs8110090; rs11466329; rs2288874; rs11466347; rs2241716; rs8179181; rs8102501; rs11466345; rs8105161; rs6508976; rs4803455; rs1989457; rs11466338; rs10405403; rs8108052; rs2241715; rs11466335; rs11466357; rs12461895; rs6508975; rs11466337; rs11466351; rs11466344; rs12462166; rs11466331; rs11466341; rs11466324; rs11466359; rs11466318; rs10420084; rs11466356; rs11466343; rs11466321; rs1549934; rs10406816; rs11466334; rs11466349; rs10416269; rs11466353; rs8179182; rs13447341; rs35383147; rs11466358; rs11551225; rs11551223; rs12977601; rs12985978; rs13306707; rs11551226; rs36102838; rs13306706; rs35025994; rs12977628; rs13306708; rs11466354; rs11466330; rs7249191; rs35169655; rs11466327; rs11466355; rs8102918; rs9749548; rs12983775; rs5828100; rs3061187; rs41275752; rs12979815; rs35276753; rs35019416; rs3061188; rs2288875; rs3061192; rs5828102; rs28730295; rs12976890; rs35312206; rs11466333; rs33950017; rs11403932; rs11466340; rs11331966; rs3061190; rs2014015; rs11466328; rs11672143; rs35976994; rs5828101; rs11466346; rs10418010; rs8108632; rs35676663; rs35197353; rs11466352; rs11307639; rs11347492; rs12980944; rs11367425; rs36050346; rs34368921; rs8103575; rs11466350; rs11466342; rs12978333; rs11466320; rs11466348; rs41333448; rs34971127; rs11673275; rs11466336; rs28769597; rs11466339; rs5828099; rs10406316; rs12976219; rs34233206; rs10417924; rs1054797; rs11083616; rs11304; rs11668109; rs11668308; rs11669342; rs11879777; rs12980298; rs12980942; rs12981053; rs12983047; rs16959007; rs1800468; rs1800469; rs1800820; rs1982072; rs2241712; rs2241713; rs2241714; rs2241718; rs2241719; rs2241720; rs34088631; rs35135271; rs3810173; rs4803454; rs6957; rs7257310; rs7257742

# Macromolecular_Interacting_Partner_34_General_References:
3470709; 3861940; 8471846; 2982829; 3162913; 9150447; 11746498; 8424942; 8424943; 8679613; 9783545; 10973241; 11062463; 12202987; 12493741; 12843182

# Macromolecular_Interacting_Partner_34_References:
12823590; 14594506; 16408114; 16632996

# Macromolecular_Interacting_Partner_35_ID:
8353

# Macromolecular_Interacting_Partner_35_Name:
Heat-shock protein beta-1

# Macromolecular_Interacting_Partner_35_Synonyms:
HspB1; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein

# Macromolecular_Interacting_Partner_35_Gene_Name:
HSPB1

# Macromolecular_Interacting_Partner_35_Protein_Sequence:
>Heatshock protein beta1
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK

# Macromolecular_Interacting_Partner_35_Number_of_Residues:
205

# Macromolecular_Interacting_Partner_35_Molecular_Weight:
22783

# Macromolecular_Interacting_Partner_35_Theoretical_pI:
6.36

# Macromolecular_Interacting_Partner_35_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_35_General_Function:
Not Available

# Macromolecular_Interacting_Partner_35_Specific_Function:
Involved in stress resistance and actin organization

# Macromolecular_Interacting_Partner_35_Pathway:
Not Available

# Macromolecular_Interacting_Partner_35_Reaction:
Not Available

# Macromolecular_Interacting_Partner_35_Pfam_Domain_Function:
PF00011:HSP20

# Macromolecular_Interacting_Partner_35_Signals:
None

# Macromolecular_Interacting_Partner_35_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_35_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_35_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_35_GenBank_ID_Protein:
662841

# Macromolecular_Interacting_Partner_35_SwissProt_ID:
HSPB1_HUMAN (P04792)

# Macromolecular_Interacting_Partner_35_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_35_Genecard_id:
HSPB1

# Macromolecular_Interacting_Partner_35_Geneatlas_id:
HSPB1

# Macromolecular_Interacting_Partner_35_hgnc_id:
HGNC:5246

# Macromolecular_Interacting_Partner_35_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_35_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_35_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock

# Macromolecular_Interacting_Partner_35_Gene_Sequence:
>600 bp
ATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGC
GACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGGGCTGCCCCGGCTGCCGGAG
GAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCC
GCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAA
CTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCGCTGGCGCGTGTCCCTGGAT
GTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATC
ACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGG
AAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAG
GGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACC
ATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCAGAAGCTGCAAAATCCGATGA


# Macromolecular_Interacting_Partner_35_GenBank_ID_Gene:
L39370

# Macromolecular_Interacting_Partner_35_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_35_Locus:
7q11.23

# Macromolecular_Interacting_Partner_35_SNPs:
rs7805625; rs35907174; rs7804492; rs28708645; rs34957294; rs11769502; rs34429571; rs2868371; rs6963310; rs2070804; rs34484713; rs2868370; rs2903814; rs2908199; rs2903813; rs34428939; rs2009836; rs2908198; rs10252296; rs1049850; rs17850892; rs28937568; rs11547167; rs17850893; rs11547165; rs1049324; rs11547163; rs1049345; rs28937569; rs11547168; rs3190199; rs11547166; rs11547164; rs1804841; rs34771861; rs6150170; rs3842186; rs35759978; rs1058872; rs33964165; rs3199775; rs1059692; rs6967273; rs11435582; rs36112129; rs36073761; rs36071791; rs35993682; rs35758543; rs2868372; rs3081056; rs35233076; rs34156885; rs7457776; rs3081054; rs35423129; rs35485732; rs34014633; rs35408134; rs10277170; rs10488574; rs1076436; rs11975763; rs11977849; rs11978285; rs11980593; rs12532935; rs12533836; rs17210045; rs2908201; rs2908203; rs7459185; rs757626

# Macromolecular_Interacting_Partner_35_General_References:
3714473; 2243808; 10777697; 9110174; 12853948; 2743305; 1763035; 2295696; 8325890; 10751411

# Macromolecular_Interacting_Partner_35_References:
16469826

# Macromolecular_Interacting_Partner_36_ID:
7867

# Macromolecular_Interacting_Partner_36_Name:
Interleukin-8 precursor

# Macromolecular_Interacting_Partner_36_Synonyms:
IL-8; CXCL8; Monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; Neutrophil- activating protein 1; NAP-1; Protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; Monocyte-derived neutrophil-activating peptide; MONAP; Emoctakin[Contains: MDNCF-a; IL8/NAP1 form I; GCP/IL-8 protein IV; Interleukin-8; IL-8(1-77; MDNCF-b; IL8/NAP1 form II; GCP/IL-8 protein II; (Ala-IL-877; IL-8(5-77; IL-8(6-77; Lymphocyte-derived neutrophil-activating factor; LYNAP; Neutrophil- activating factor; NAF; MDNCF-c; IL8/NAP1 form III; GCP/IL-8 protein I; (Ser-IL-872; IL-8(7-77; IL8/NAP1 form IV; GCP/IL-8 protein V; IL-8(8-77; IL8/NAP1 form V; GCP/IL-8 protein VI; IL- 8(9-77; IL8/NAP1 form VI; GCP/IL-8 protein III]

# Macromolecular_Interacting_Partner_36_Gene_Name:
IL8

# Macromolecular_Interacting_Partner_36_Protein_Sequence:
>Interleukin8 precursor
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

# Macromolecular_Interacting_Partner_36_Number_of_Residues:
99

# Macromolecular_Interacting_Partner_36_Molecular_Weight:
11098

# Macromolecular_Interacting_Partner_36_Theoretical_pI:
9.09

# Macromolecular_Interacting_Partner_36_GO_Classification:
>>>
Function:  chemokine activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_36_General_Function:
Not Available

# Macromolecular_Interacting_Partner_36_Specific_Function:
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

# Macromolecular_Interacting_Partner_36_Pathway:
Not Available

# Macromolecular_Interacting_Partner_36_Reaction:
Not Available

# Macromolecular_Interacting_Partner_36_Pfam_Domain_Function:
PF00048:IL8

# Macromolecular_Interacting_Partner_36_Signals:
1-20

# Macromolecular_Interacting_Partner_36_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_36_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_36_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_36_GenBank_ID_Protein:
34519

# Macromolecular_Interacting_Partner_36_SwissProt_ID:
IL8_HUMAN (P10145)

# Macromolecular_Interacting_Partner_36_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_36_Genecard_id:
IL8

# Macromolecular_Interacting_Partner_36_Geneatlas_id:
IL8

# Macromolecular_Interacting_Partner_36_hgnc_id:
HGNC:6025

# Macromolecular_Interacting_Partner_36_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_36_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_36_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_36_Gene_Sequence:
>300 bp
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA


# Macromolecular_Interacting_Partner_36_GenBank_ID_Gene:
Y00787

# Macromolecular_Interacting_Partner_36_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_36_Locus:
4q13-q21

# Macromolecular_Interacting_Partner_36_SNPs:
rs1803205; rs1126647; rs2227537; rs2227538; rs34915905; rs2227545; rs2227546; rs12420; rs11733933; rs2227540; rs2227549; rs2227307; rs2227543; rs2227306; rs2227541; rs2227542; rs2227539; rs2227532; rs2227528; rs2227534; rs4073; rs2227531; rs7682639; rs2227527; rs2227544; rs3181685; rs35607711; rs16849942; rs11545234; rs2227550; rs2227548; rs3756069; rs34428214; rs2227536; rs41458346; rs10938092; rs2227530; rs10719080; rs2227533; rs2227535; rs2227529; rs36078377; rs13112910; rs41505147; rs11729759; rs11730284; rs11730667; rs11940656; rs11944402; rs13106097; rs13142454; rs16849925; rs16849928; rs16849934; rs16849958; rs17202249; rs1951236; rs1951237; rs1951239; rs1951240; rs1951242; rs1951699; rs1951700; rs1957661; rs2227517; rs2227518; rs2227524; rs2227525; rs2227526; rs4694178; rs4694635; rs4694636; rs4694637; rs7658422; rs7674884

# Macromolecular_Interacting_Partner_36_General_References:
3260265; 2953813; 2664463; 2663993; 2648135; 2655583; 2659722; 3279957; 3322281; 3480540; 2145175; 2523801; 2212672; 2007144; 11023497; 1639201; 2681204; 2184886; 8631339; 10368283; 2182630; 2005614; 1988949; 10707023

# Macromolecular_Interacting_Partner_36_References:
12608468; 15958071

# Macromolecular_Interacting_Partner_37_ID:
7936

# Macromolecular_Interacting_Partner_37_Name:
Apoptosis regulator Bcl-2

# Macromolecular_Interacting_Partner_37_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_37_Gene_Name:
BCL2

# Macromolecular_Interacting_Partner_37_Protein_Sequence:
>Apoptosis regulator Bcl2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

# Macromolecular_Interacting_Partner_37_Number_of_Residues:
239

# Macromolecular_Interacting_Partner_37_Molecular_Weight:
26266

# Macromolecular_Interacting_Partner_37_Theoretical_pI:
7.32

# Macromolecular_Interacting_Partner_37_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of cellular physiological process
Process:  regulation of programmed cell death
Process:  regulation of apoptosis
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_37_General_Function:
Not Available

# Macromolecular_Interacting_Partner_37_Specific_Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

# Macromolecular_Interacting_Partner_37_Pathway:
Not Available

# Macromolecular_Interacting_Partner_37_Reaction:
Not Available

# Macromolecular_Interacting_Partner_37_Pfam_Domain_Function:
PF00452:Bcl-2;
PF02180:BH4

# Macromolecular_Interacting_Partner_37_Signals:
None

# Macromolecular_Interacting_Partner_37_Transmembrane_Regions:
212-233

# Macromolecular_Interacting_Partner_37_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_37_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_37_GenBank_ID_Protein:
179367

# Macromolecular_Interacting_Partner_37_SwissProt_ID:
BCL2_HUMAN (P10415)

# Macromolecular_Interacting_Partner_37_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_37_Genecard_id:
BCL2

# Macromolecular_Interacting_Partner_37_Geneatlas_id:
BCL2

# Macromolecular_Interacting_Partner_37_hgnc_id:
HGNC:990

# Macromolecular_Interacting_Partner_37_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_37_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_37_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass membrane protein. Nucleus; nuclear membrane; single- pass membrane protein. Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Macromolecular_Interacting_Partner_37_Gene_Sequence:
>720 bp
ATGGCGCACGCTGGGAGAACGGGGTACGACAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGCGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGGCCCTCCGCCAAGCC
GGCGACGACTTCTCCCGCCGCTACCGCGGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGAGCCACAAGTGA


# Macromolecular_Interacting_Partner_37_GenBank_ID_Gene:
M13994

# Macromolecular_Interacting_Partner_37_Chromosome_Location:
Chromosome:18

# Macromolecular_Interacting_Partner_37_Locus:
18q21.33|18q21.3

# Macromolecular_Interacting_Partner_37_SNPs:
rs1800477; rs1801018; rs1564483; rs1016860; rs4987853; rs4987861; rs4987843; rs4987852; rs3744935; rs4987864; rs4987856; rs4987854; rs4987855; rs4987846; rs4987851; rs4987858; rs4987850; rs4987859; rs4987865; rs4987845; rs4987869; rs3744937; rs4987847; rs1473418; rs4987867; rs720321; rs1383596; rs1944419; rs1531697; rs2046136; rs1545812; rs1481031; rs2332673; rs726510; rs899968; rs2062011; rs2850763; rs1381548; rs949037; rs2156192; rs2850761; rs7226979; rs1009726; rs4940576; rs2850762; rs6567334; rs2551397; rs2849377; rs2199937; rs4987792; rs11872403; rs11152377; rs4941195; rs4941183; rs2156190; rs2062010; rs8094489; rs11152375; rs12606418; rs8083946; rs726511; rs3810027; rs1542578; rs8094651; rs1462129; rs4941189; rs4941192; rs3810031; rs3943258; rs8088662; rs8096380; rs4940573; rs7228914; rs11661511; rs7240326; rs2156193; rs8086404; rs6567336; rs2849381; rs8094315; rs11876772; rs4987790; rs11152370; rs4987752; rs4940575; rs4456611; rs1893506; rs2046135; rs12457700; rs8088100; rs7242402; rs11661497; rs4940572; rs1944420; rs9955190; rs1944422; rs12454650; rs1977971; rs8089331; rs2850758; rs2046137; rs1573493; rs8084922; rs8089538; rs4987802; rs6567328; rs8095050; rs2156191; rs2849380; rs1481032; rs11875184; rs1807999; rs9807663; rs4940574; rs7230053; rs1982674; rs12457170; rs4941188; rs1344229; rs7234941; rs6567327; rs11152374; rs11152372; rs9965844; rs6567326; rs7239838; rs9962222; rs9959874; rs4940571; rs2187162; rs4987819; rs2051423; rs3810028; rs899966; rs4987739; rs6567329; rs4941185; rs4987718; rs10503079; rs8098548; rs3744933; rs3744948; rs17070798; rs4987760; rs8098848; rs4987788; rs7243201; rs4941187; rs12968517; rs4987772; rs4987722; rs4987803; rs731014; rs3744951; rs1982673; rs4987736; rs17070904; rs6567330; rs11659758; rs2850760; rs9967405; rs8099575; rs17757981; rs9630855; rs4987786; rs12454712; rs12457893; rs4987724; rs8099140; rs12970840; rs4987778; rs4987831; rs4987829; rs1026825; rs12458289; rs9972995; rs10503077; rs6567325; rs4987823; rs4987765; rs4987726; rs4987757; rs11152371; rs12605881; rs4987746; rs11875971; rs4987827; rs12961976; rs4987795; rs4987797; rs899965; rs7244617; rs1531695; rs9962656; rs12457831; rs11872329; rs4987838; rs4941184; rs2051424; rs2615200; rs7242542; rs8094630; rs7236090; rs6567324; rs7231914; rs1893806; rs4987768; rs17070959; rs1005793; rs8085707; rs17070739; rs11875686; rs17679032; rs4987721; rs4987808; rs765102; rs8097624; rs3744950; rs4987801; rs1009725; rs6567335; rs17070848; rs17685559; rs956572; rs12961672; rs11663275; rs744569; rs4987764; rs12457190; rs4941186; rs17070861; rs4941194; rs4987835; rs2170294; rs4987755; rs6567331; rs4987841; rs4987737; rs9959983; rs768058; rs7243091; rs8095077; rs4987725; rs4987733; rs17756073; rs11877475; rs8093973; rs4987839; rs4987759; rs4987783; rs960804; rs4987743; rs4987779; rs10503078; rs17757541; rs899964; rs7230970; rs4987716; rs7232625; rs9951943; rs9958550; rs8092560; rs4941190; rs12457371; rs4987828; rs3826622; rs8096471; rs8083727; rs4987821; rs2849382; rs9962051; rs17756365; rs17070913; rs8087120; rs2170295; rs4987810; rs6567332; rs899967; rs4987774; rs1381546; rs10460157; rs11873429; rs4987826; rs4987798; rs1473435; rs7242904; rs4987809; rs7242501; rs4987800; rs7232512; rs12957119; rs10164240; rs4987742; rs3948977; rs4987719; rs12458944; rs4987796; rs7231901; rs17678177; rs8099218; rs2551399; rs4987770; rs4987825; rs17070714; rs4987781; rs12962644; rs4987812; rs12963263; rs4987834; rs4987747; rs4987767; rs17758695; rs9963148; rs17841945; rs4987744; rs9959769; rs12457361; rs9946649; rs4987794; rs11152373; rs11872297; rs17070779; rs4987728; rs12963776; rs12958785; rs17686373; rs1976005; rs12457841; rs8092884; rs7240319; rs9946637; rs9961642; rs17759096; rs11877911; rs4987773; rs1944421; rs2170296; rs11877925; rs9961796; rs7230177; rs4987715; rs4987732; rs17070777; rs11874082; rs9965829; rs4987761; rs17758456; rs17062654; rs4987789; rs4987771; rs17070827; rs17758816; rs7232082; rs11661184; rs12962650; rs3842401; rs8098586; rs17678294; rs17677569; rs17070818; rs954954; rs9957149; rs1541298; rs4987717; rs9962421; rs17070841; rs4987730; rs8097918; rs8089306; rs12967026; rs7236202; rs4987750; rs17685987; rs2840358; rs4987787; rs4987780; rs17841946; rs4987723; rs7237139; rs1481030; rs12454618; rs12968867; rs9966563; rs17070877; rs17070809; rs9958905; rs6567333; rs3810030; rs4987741; rs12964150; rs9972996; rs7245234; rs1381547; rs17756248; rs4987807; rs12604822; rs17070735; rs17756266; rs4987824; rs12456572; rs2850755; rs17070943; rs4987749; rs17070946; rs17759659; rs12605858; rs4987791; rs4987815; rs9962963; rs3927911; rs8091529; rs4987822; rs8085473; rs4987731; rs17758403; rs4987745; rs4987818; rs9965425; rs4987793; rs1541295; rs4987832; rs12455492; rs4987720; rs4987817; rs2849379; rs17070750; rs4987830; rs4987873; rs2448799; rs8087606; rs4987872; rs2279115; rs41301945; rs5825508; rs2078303; rs4987849; rs17070680; rs41306972; rs34741396; rs4987866; rs34360708; rs34883036; rs1050618; rs34811186; rs4987707; rs4987868; rs4987844; rs4987862; rs34223591; rs4987842; rs4987870; rs4987848; rs4987710; rs4987860; rs34143126; rs4987706; rs3744936; rs4987863; rs4987857; rs11351478; rs35558540; rs36046351; rs34986306; rs11384331; rs12327138; rs34592237; rs34479040; rs35443488; rs35735146; rs4987738; rs35954402; rs9953797; rs11286497; rs34714510; rs34470267; rs2127872; rs34356346; rs10597397; rs7230110; rs5825509; rs4987769; rs11346802; rs35765197; rs35992365; rs28744646; rs35421280; rs7242051; rs7230703; rs3216124; rs11878084; rs3833192; rs9320014; rs34032861; rs10536242; rs28613776; rs35702853; rs35957660; rs11877270; rs36089071; rs11411155; rs34999271; rs28603232; rs8099362; rs11424742; rs34128466; rs4987740; rs36230193; rs35775563; rs34585115; rs9944895; rs4987754; rs34926393; rs35844118; rs4987753; rs4987763; rs9949240; rs4987751; rs7242531; rs11421019; rs28669125; rs28550381; rs28502762; rs28662060; rs34092929; rs28702921; rs35942763; rs35275357; rs35195646; rs2332672; rs7232179; rs11381388; rs34385891; rs34140806; rs28460613; rs2187163; rs35366804; rs28699603; rs4384687; rs35180138; rs12958555; rs4987713; rs4987805; rs35063180; rs28564323; rs9959358; rs4987837; rs596876; rs4987799; rs4987814; rs34360704; rs34927632; rs36074022; rs7232529; rs4987840; rs4987813; rs34603960; rs34737549; rs34810572; rs4987782; rs12956558; rs34724235; rs35832816; rs11396022; rs4987734; rs35916533; rs11426842; rs34422779; rs35788320; rs7243686; rs34269955; rs34821656; rs34331087; rs4987735; rs2615199; rs7245040; rs28537871; rs34628711; rs34530559; rs34280008; rs9946231; rs34246997; rs35618914; rs7504762; rs11285614; rs9955851; rs4987784; rs12454033; rs35117243; rs4987833; rs35832711; rs11876939; rs4987711; rs2085958; rs4987776; rs4987816; rs11271834; rs9807796; rs34929825; rs2849378; rs34498028; rs8094130; rs34272291; rs8089583; rs5825512; rs35786465; rs11437030; rs3810029; rs10560567; rs34392530; rs11875445; rs36010160; rs33935449; rs1870863; rs11874495; rs28566629; rs35829205; rs10604257; rs12327294; rs4987758; rs11407054; rs34122166; rs35501583; rs12454460; rs34597011; rs34215080; rs11664592; rs11330056; rs11348997; rs4987762; rs11346034; rs641060; rs35852603; rs34970907; rs7238198; rs35043985; rs10640757; rs35621103; rs34019962; rs4987820; rs11333396; rs12326606; rs11269260; rs36107927; rs34843082; rs35457535; rs12969008; rs10564352; rs4987748; rs35869219; rs1273018; rs28417258; rs17070962; rs34520768; rs34167266; rs34372247; rs34877412; rs1138828; rs12962685; rs12955832; rs28588396; rs12958518; rs33983598; rs4411604; rs2849374; rs8089784; rs1679896; rs12956104; rs35051109; rs28552905; rs3744949; rs34724758; rs7230557; rs4987811; rs34616260; rs34660120; rs34455531; rs7231840; rs4987766; rs11343409; rs11377778; rs11282101; rs11663364; rs12327297; rs12957272; rs34096346; rs12954887; rs35880134; rs8097683; rs7245041; rs11152376; rs11307145; rs11389759; rs34302549; rs35608542; rs34601248; rs35378587; rs34971240; rs7239903; rs4987727; rs34857794; rs34026129; rs36077676; rs34008827; rs11289698; rs28552745; rs35997590; rs36078664; rs10688243; rs35024611; rs35764546; rs34513836; rs34355655; rs720849; rs10718817; rs36027128; rs8092584; rs4987756; rs35555671; rs7242090; rs35771638; rs1789627; rs1271892; rs7236823; rs4987785; rs4987714; rs1462128; rs35032484; rs12605689; rs7239542; rs4941193; rs10537349; rs12970504; rs10642228; rs35689542; rs11393921; rs12962313; rs4987836; rs36095867; rs35696527; rs34059678; rs35046846; rs34022610; rs5825511; rs35369252; rs34870728; rs34960660; rs7244494; rs36099507; rs35770276; rs35956166; rs12964435; rs28562101; rs34051656; rs11271898; rs4987804; rs4987729; rs7231259; rs35818172; rs34831717; rs28464692; rs4987777; rs34298527; rs7504665; rs35161404; rs5825510; rs35593106; rs35291046; rs7230565; rs34430054; rs8098774; rs34875078; rs34683668; rs28484798; rs1531696; rs34596364; rs11399943; rs4987712; rs28431965; rs765479; rs34457708; rs36088248; rs12958359; rs2516293; rs34174534; rs35525138; rs2551400; rs35834230; rs4987705; rs4987871; rs2448798; rs2472571; rs35953169; rs34619379; rs10460159; rs11660715; rs17070659; rs17676919; rs17676949; rs17749561; rs1944423; rs2051422; rs2448800; rs2448804; rs2448805; rs2448806; rs2472572; rs2472574; rs2472576; rs2472577; rs2472578; rs2472579; rs2472581; rs2551402; rs2551404; rs2551405; rs2850764; rs698708; rs7243985; rs8086644; rs8094041; rs8099294; rs9320013; rs9945794; rs9957746; rs9989529

# Macromolecular_Interacting_Partner_37_General_References:
3523487; 1508712; 2875799; 2834197; 3285301; 1339299; 2250705; 8183370; 9395403; 8668206; 11368354; 10567572; 11463391; 12901880

# Macromolecular_Interacting_Partner_37_References:
12974082; 15934930

# Macromolecular_Interacting_Partner_38_ID:
8170

# Macromolecular_Interacting_Partner_38_Name:
Vascular cell adhesion protein 1 precursor

# Macromolecular_Interacting_Partner_38_Synonyms:
V-CAM 1; CD106 antigen; INCAM-100

# Macromolecular_Interacting_Partner_38_Gene_Name:
VCAM1

# Macromolecular_Interacting_Partner_38_Protein_Sequence:
>Vascular cell adhesion protein 1 precursor
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWR
TQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPE
IHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEV
TFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGG
SVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKN
RKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVR
SEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSS
VTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKA
LVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFP
APKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQL
KDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFA
RKANMKGSYSLVEAQKSKV

# Macromolecular_Interacting_Partner_38_Number_of_Residues:
739

# Macromolecular_Interacting_Partner_38_Molecular_Weight:
81277

# Macromolecular_Interacting_Partner_38_Theoretical_pI:
4.87

# Macromolecular_Interacting_Partner_38_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cellular process
Process:  cell adhesion
Process:  cell-cell adhesion
 ||
>>>
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_38_General_Function:
Not Available

# Macromolecular_Interacting_Partner_38_Specific_Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation

# Macromolecular_Interacting_Partner_38_Pathway:
Not Available

# Macromolecular_Interacting_Partner_38_Reaction:
Not Available

# Macromolecular_Interacting_Partner_38_Pfam_Domain_Function:
PF05790:C2-set;
PF07679:I-set;
PF00047:ig;
PF07686:V-set

# Macromolecular_Interacting_Partner_38_Signals:
1-24

# Macromolecular_Interacting_Partner_38_Transmembrane_Regions:
699-720

# Macromolecular_Interacting_Partner_38_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_38_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_38_GenBank_ID_Protein:
179886

# Macromolecular_Interacting_Partner_38_SwissProt_ID:
VCAM1_HUMAN (P19320)

# Macromolecular_Interacting_Partner_38_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_38_Genecard_id:
VCAM1

# Macromolecular_Interacting_Partner_38_Geneatlas_id:
VCAM1

# Macromolecular_Interacting_Partner_38_hgnc_id:
HGNC:12663

# Macromolecular_Interacting_Partner_38_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_38_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_38_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_38_Gene_Sequence:
>1944 bp
ATGCCTGGGAAGATGGTCGTGATCCTTGGAGCCTCAAATATACTTTGGATAATGTTTGCA
GCTTCTCAAGCTTTTAAAATCGAGACCACCCCAGAATCTAGATATCTTGCTCAGATTGGT
GACTCCGTCTCATTGACTTGCAGCACCACAGGCTGTGAGTCCCCATTTTTCTCTTGGAGA
ACCCAGATAGATAGTCCACTGAATGGGAAGGTGACGAATGAGGGGACCACATCTACGCTG
ACAATGAATCCTGTTAGTTTTGGGAACGAACACTCTTACCTGTGCACAGCAACTTGTGAA
TCTAGGAAATTGGAAAAAGGAATCCAGGTGGAGATCTACTCTTTTCCTAAGGATCCAGAG
ATTCATTTGAGTGGCCCTCTGGAGGCTGGGAAGCCGATCACAGTCAAGTGTTCAGTTGCT
GATGTATACCCATTTGACAGGCTGGAGATAGACTTACTGAAAGGAGATCATCTCATGAAG
AGTCAGGAATTTCTGGAGGATGCAGACAGGAAGTCCCTGGAAACCAAGAGTTTGGAAGTA
ACCTTTACTCCTGTCATTGAGGATATTGGAAAAGTTCTTGTTTGCCGAGCTAAATTACAC
ATTGATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAAGAATTGCAAGTCTAC
ATATCACCCAAGAATACAGTTATTTCTGTGAATCCATCCACAAAGCTGCAAGAAGGTGGC
TCTGTGACCATGACCTGTTCCAGCGAGGGTCTACCAGCTCCAGAGATTTTCTGGAGTAAG
AAATTAGATAATGGGAATCTACAGCACCTTTCTGGAAATGCAACTCTCACCTTAATTGCT
ATGAGGATGGAAGATTCTGGAATTTATGTGTGTGAAGGAGTTAATTTGATTGGGAAAAAC
AGAAAAGAGGTGGAATTAATTGTTCAAGCATTCCCTAGAGATCCAGAAATCGAGATGAGT
GGTGGCCTCGTGAATGGGAGCTCTGTCACTGTAAGCTGCAAGGTTCCTAGCGTGTACCCC
CTTGACCGGCTGGAGATTGAATTACTTAAGGGGGAGACTATTCTGGAGAATATAGAGTTT
TTGGAGGATACGGATATGAAATCTCTAGAGAACAAAAGTTTGGAAATGACCTTCATCCCT
ACCATTGAAGATACTGGAAAAGCTCTTGTTTGTCAGGCTAAGTTACATATTGATGACATG
GAATTCGAACCCAAACAAAGGCAGAGTACGCAAACACTTTATGTCAATGTTGCCCCCAGA
GATACAACCGTCTTGGTCAGCCCTTCCTCCATCCTGGAGGAAGGCAGTTCTGTGAATATG
ACATGCTTGAGCCAGGGCTTTCCTGCTCCGAAAATCCTGTGGAGCAGGCAGCTCCCTAAC
GGGGAGCTACAGCCTCTTTCTGAGAATGCAACTCTCACCTTAATTTCTACAAAAATGGAA
GATTCTGGGGTTTATTTATGTGAAGGAATTAACCAGGCTGGAAGAAGCAGAAAGGAAGTG
GAATTAATTATCCAAGTTACTCCAAAAGACATAAAACTTACAGCTTTTCCTTCTGAGAGT
GTCAAAGAAGGAGACACTGTCATCATCTCTTGTACATGTGGAAATGTTCCAGAAACATGG
ATAATCCTGAAGAAAAAAGCGGAGACAGGAGACACAGTACTAAAATCTATAGATGGCGCC
TATACCATCCGAAAGGCCCAGTTGAAGGATGCGGGAGTATATGAATGTGAATCTAAAAAC
AAAGTTGGCTCACAATTAAGAAGTTTAACACTTGATGTTCAAGGAAGAGAAAACAACAAA
GACTATTTTTCTCCTGAGCTTCTCGTGCTCTATTTTGCATCCTCCTTAATAATACCTGCC
ATTGGAATGATAATTTACTTTGCAAGAAAAGCCAACATGAAGGGGTCATATAGTCTTGTA
GAAGCACAGAAATCAAAAGTGTAG

# Macromolecular_Interacting_Partner_38_GenBank_ID_Gene:
M30257

# Macromolecular_Interacting_Partner_38_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_38_Locus:
1p32-p31

# Macromolecular_Interacting_Partner_38_SNPs:
rs3783613; rs3783612; rs3783611; rs3783615; rs34100871; rs34228330; rs34199378; rs3176879; rs3176878; rs3783621; rs3783618; rs3783617; rs3783608; rs3783609; rs3783619; rs3783610; rs3783607; rs3176875; rs3176860; rs3176874; rs3176876; rs3917012; rs2392221; rs3181088; rs3765685; rs3819950; rs3917041; rs3176870; rs3917040; rs3176861; rs3917037; rs2209627; rs3176862; rs3917067; rs3176869; rs3917016; rs3917043; rs3917038; rs3917075; rs3917033; rs3917058; rs3917034; rs3917019; rs3917020; rs3917064; rs3917042; rs3176871; rs3176863; rs3917059; rs3917018; rs1476408; rs3176877; rs3917009; rs3917062; rs3176867; rs3917036; rs3181091; rs3917053; rs3181089; rs3917032; rs3917028; rs3917070; rs3917056; rs3917060; rs3917047; rs3917072; rs3917057; rs3917011; rs3917065; rs3917074; rs34186667; rs3917051; rs3176864; rs3917068; rs3917015; rs3917049; rs3917073; rs3917052; rs3917010; rs3176859; rs3917069; rs3917071; rs3917066; rs3917014; rs3176868; rs3917055; rs3917031; rs3917063; rs34599539; rs3917008; rs1041163; rs3181092; rs1409419; rs3917024; rs3181093; rs3170794; rs3181087; rs3783598; rs3783624; rs3783595; rs3783605; rs3917022; rs3917025; rs3783601; rs3783597; rs3917027; rs3917026; rs3783599; rs3783603; rs34708918; rs17123276; rs34682069; rs41287272; rs41402047; rs3194002; rs3783620; rs12740248; rs3917048; rs34736359; rs35831577; rs36046590; rs35811606; rs34871919; rs34681548; rs10680526; rs34203893; rs3917013; rs34484900; rs35625117; rs3176872; rs35904710; rs35377403; rs35668724; rs3917050; rs3917061; rs36115922; rs34602730; rs3917046; rs35885801; rs34934334; rs3917039; rs3917045; rs3181090; rs34552536; rs3917054; rs3917035; rs3917030; rs3176865; rs35026515; rs35742683; rs34768146; rs3917044; rs3917017; rs34577442; rs34037455; rs3917029; rs3783606; rs3783600; rs3917021; rs35200787; rs17109912; rs11420952; rs1800821; rs11302130; rs3834000; rs34900848; rs10493936; rs12080503; rs12129732; rs12240047; rs12403247; rs12409568; rs12732056; rs12747073; rs1571049; rs1582090; rs1582091; rs2050471; rs2094241; rs2209628; rs34853105; rs35964031; rs35978793; rs3917078; rs4520436; rs4584412; rs6660837; rs6680254

# Macromolecular_Interacting_Partner_38_General_References:
2688898; 1699207; 1707873; 1715583; 1379595; 1707234; 1377228; 7531291; 7539925

# Macromolecular_Interacting_Partner_38_References:
15068815; 15168812; 16496611

# Macromolecular_Interacting_Partner_39_ID:
8213

# Macromolecular_Interacting_Partner_39_Name:
Chymase precursor

# Macromolecular_Interacting_Partner_39_Synonyms:
Mast cell protease I

# Macromolecular_Interacting_Partner_39_Gene_Name:
CMA1

# Macromolecular_Interacting_Partner_39_Protein_Sequence:
>Chymase precursor
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN

# Macromolecular_Interacting_Partner_39_Number_of_Residues:
247

# Macromolecular_Interacting_Partner_39_Molecular_Weight:
27325

# Macromolecular_Interacting_Partner_39_Theoretical_pI:
9.71

# Macromolecular_Interacting_Partner_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_39_General_Function:
Not Available

# Macromolecular_Interacting_Partner_39_Specific_Function:
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion

# Macromolecular_Interacting_Partner_39_Pathway:
Not Available

# Macromolecular_Interacting_Partner_39_Reaction:
Preferential cleavage: Phe-|- > Tyr-|- > Trp-|- > Leu-|-

# Macromolecular_Interacting_Partner_39_Pfam_Domain_Function:
PF00089:Trypsin

# Macromolecular_Interacting_Partner_39_Signals:
1-19

# Macromolecular_Interacting_Partner_39_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_39_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_39_EC_Link:
EC 3.4.21.39

# Macromolecular_Interacting_Partner_39_GenBank_ID_Protein:
180542

# Macromolecular_Interacting_Partner_39_SwissProt_ID:
CMA1_HUMAN (P23946)

# Macromolecular_Interacting_Partner_39_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_39_Genecard_id:
CMA1

# Macromolecular_Interacting_Partner_39_Geneatlas_id:
CMA1

# Macromolecular_Interacting_Partner_39_hgnc_id:
HGNC:2097

# Macromolecular_Interacting_Partner_39_PDB_ID:
1NN6

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_39_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_39_Subcellular_Location:
Secreted protein. Cytoplasmic granule. Note=Mast cell granules

# Macromolecular_Interacting_Partner_39_Gene_Sequence:
>744 bp
ATGCTGCTTCTTCCTCTCCCCCTGCTGCTCTTTCTCTTGTGCTCCAGAGCTGAAGCTGGG
GAGATCATCGGGGGCACAGAATGCAAGCCACATTCCCGCCCCTACATGGCCTACCTGGAA
ATTGTAACTTCCAACGGTCCCTCAAAATTTTGTGGTGGTTTCCTTATAAGACGGAACTTT
GTGCTGACGGCTGCTCATTGTGCAGGAAGGTCTATAACAGTCACCCTTGGAGCCCATAAC
ATAACAGAGGAAGAAGACACATGGCAGAAGCTTGAGGTTATAAAGCAATTCCGTCATCCA
AAATATAACACTTCTACTCTTCACCACGATATCATGTTACTAAAGTTGAAGGAGAAAGCC
AGCCTGACCCTGGCTGTGGGGACACTCCCCTTCCCATCACAATTCAACTTTGTCCCACCT
GGGAGAATGTGCCGGGTGGCTGGCTGGGGAAGAACAGGTGTGTTGAAGCCGGGCTCAGAC
ACTCTGCAAGAGGTGAAGCTGAGACTCATGGATCCCCAGGCCTGCAGCCACTTCAGAGAC
TTTGACCACAATCTTCAGCTGTGTGTGGGCAATCCCAGGAAGACAAAATCTGCATTTAAG
GGAGACTCTGGGGGCCCTCTTCTGTGTGCTGGGGTGGCCCAGGGCATCGTATCCTATGGA
CGGTCGGATGCAAAGCCCCCTGCTGTCTTCACCCGAATCTCCCATTACCGGCCCTGGATC
AACCAGATCCTGCAGGCAAATTAA

# Macromolecular_Interacting_Partner_39_GenBank_ID_Gene:
M64269

# Macromolecular_Interacting_Partner_39_Chromosome_Location:
Chromosome:14

# Macromolecular_Interacting_Partner_39_Locus:
14q11.2

# Macromolecular_Interacting_Partner_39_SNPs:
rs5247; rs5249; rs1951133; rs1885108; rs2073335; rs12100565; rs10220622; rs10140250; rs5248; rs10135806; rs7153678; rs880678; rs1956923; rs5250; rs1800875; rs5244; rs1956922; rs11623993; rs12892955; rs12893439; rs3759635; rs1800876; rs5245; rs1956920; rs1885110; rs10138131; rs1956921; rs1885109; rs8008222; rs1956924; rs2104080; rs17104478; rs5246; rs13306252; rs13306254; rs7142020; rs13306251; rs13306253; rs35717389; rs5807257; rs8011230; rs34077376; rs10638524; rs2332395; rs2332392; rs34375143; rs8013075; rs2332393; rs12590297; rs5807259; rs2877666; rs34585765; rs34033540; rs2332394; rs5807258; rs34731130; rs4077943; rs35154295; rs36049344; rs2332396; rs11621180; rs11624048; rs12434912; rs12589088; rs17184822; rs17184843; rs1885107; rs1951134; rs1956917; rs1956918; rs1956925; rs1956926; rs1956927; rs1956928; rs1956929; rs1956930; rs1956931; rs1956932; rs1998229; rs1998230; rs2007316; rs2093257; rs2104081; rs2332353; rs2332354; rs34657109; rs4519248; rs4555074; rs4600392; rs4981533; rs4982956; rs6573840; rs7150627; rs7151943; rs7159825; rs8011895; rs911371; rs927278; rs927281

# Macromolecular_Interacting_Partner_39_General_References:
2071582; 1894611; 8495723; 2049082; 9400368; 9931257

# Macromolecular_Interacting_Partner_39_References:
15765403; 16042588; 16150873

# Macromolecular_Interacting_Partner_40_ID:
8081

# Macromolecular_Interacting_Partner_40_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_40_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_40_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_40_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_40_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_40_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_40_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_40_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_40_General_Function:
Not Available

# Macromolecular_Interacting_Partner_40_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_40_Pathway:
Not Available

# Macromolecular_Interacting_Partner_40_Reaction:
Not Available

# Macromolecular_Interacting_Partner_40_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_40_Signals:
1-21

# Macromolecular_Interacting_Partner_40_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_40_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_40_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_40_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_40_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_40_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_40_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_40_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_40_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_40_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_40_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_40_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_40_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_40_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_40_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_40_Locus:
7q31.3

# Macromolecular_Interacting_Partner_40_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_40_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_40_References:
15605705

# Macromolecular_Interacting_Partner_41_ID:
8227

# Macromolecular_Interacting_Partner_41_Name:
T-lymphocyte activation antigen CD86 precursor

# Macromolecular_Interacting_Partner_41_Synonyms:
Activation B7-2 antigen; CTLA-4 counter-receptor B7.2; B70; FUN-1; BU63

# Macromolecular_Interacting_Partner_41_Gene_Name:
CD86

# Macromolecular_Interacting_Partner_41_Protein_Sequence:
>Tlymphocyte activation antigen CD86 precursor
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF

# Macromolecular_Interacting_Partner_41_Number_of_Residues:
329

# Macromolecular_Interacting_Partner_41_Molecular_Weight:
37697

# Macromolecular_Interacting_Partner_41_Theoretical_pI:
6.91

# Macromolecular_Interacting_Partner_41_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_41_General_Function:
Not Available

# Macromolecular_Interacting_Partner_41_Specific_Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation

# Macromolecular_Interacting_Partner_41_Pathway:
Not Available

# Macromolecular_Interacting_Partner_41_Reaction:
Not Available

# Macromolecular_Interacting_Partner_41_Pfam_Domain_Function:
PF07686:V-set

# Macromolecular_Interacting_Partner_41_Signals:
1-23

# Macromolecular_Interacting_Partner_41_Transmembrane_Regions:
248-268

# Macromolecular_Interacting_Partner_41_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_41_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_41_GenBank_ID_Protein:
439839

# Macromolecular_Interacting_Partner_41_SwissProt_ID:
CD86_HUMAN (P42081)

# Macromolecular_Interacting_Partner_41_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_41_Genecard_id:
CD86

# Macromolecular_Interacting_Partner_41_Geneatlas_id:
CD86

# Macromolecular_Interacting_Partner_41_hgnc_id:
HGNC:1705

# Macromolecular_Interacting_Partner_41_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_41_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_41_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_41_Gene_Sequence:
>972 bp
ATGGGACTGAGTAACATTCTCTTTGTGATGGCCTTCCTGCTCTCTGGTGCTGCTCCTCTG
AAGATTCAAGCTTATTTCAATGAGACTGCAGACCTGCCATGCCAATTTGCAAACTCTCAA
AACCAAAGCCTGAGTGAGCTAGTAGTATTTTGGCAGGACCAGGAAAACTTGGTTCTGAAT
GAGGTATACTTAGGCAAAGAGAAATTTGACAGTGTTCATTCCAAGTATATGGGCCGCACA
AGTTTTGATTCGGACAGTTGGACCCTGAGACTTCACAATCTTCAGATCAAGGACAAGGGC
TTGTATCAATGTATCATCCATCACAAAAAGCCCACAGGAATGATTCGCATCCACCAGATG
AATTCTGAACTGTCAGTGCTTGCTAACTTCAGTCAACCTGAAATAGTACCAATTTCTAAT
ATAACAGAAAATGTGTACATAAATTTGACCTGCTCATCTATACACGGTTACCCAGAACCT
AAGAAGATGAGTGTTTTGCTAAGAACCAAGAATTCAACTATCGAGTATGATGGTATTATG
CAGAAATCTCAAGATAATGTCACAGAACTGTACGACGTTTCCATCAGCTTGTCTGTTTCA
TTCCCTGATGTTACGAGCAATATGACCATCTTCTGTATTCTGGAAACTGACAAGACGCGG
CTTTTATCTTCACCTTTCTCTATAGAGCTTGAGGACCCTCAGCCTCCCCCAGACCACATT
CCTTGGATTACAGCTGTACTTCCAACAGTTATTATATGTGTGATGGTTTTCTGTCTAATT
CTATGGAAATGGAAGAAGAAGAAGCGGCCTCGCAACTCTTATAAATGTGGAACCAACACA
ATGGAGAGGGAAGAGAGTGAACAGACCAAGAAAAGAGAAAAAATCCATATACCTGAAAGA
TCTGATGAAGCCCAGCGTGTTTTTAAAAGTTCGAAGACATCTTCATGCGACAAAAGTGAT
ACATGTTTTTAA

# Macromolecular_Interacting_Partner_41_GenBank_ID_Gene:
U04343

# Macromolecular_Interacting_Partner_41_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_41_Locus:
3q21

# Macromolecular_Interacting_Partner_41_SNPs:
rs2681417; rs1129055; rs9282642; rs9282648; rs9831894; rs2715261; rs11717893; rs6780894; rs2715262; rs17281995; rs2681422; rs2715279; rs1915087; rs6805035; rs2715280; rs11575853; rs3749202; rs9282641; rs9282646; rs9282644; rs2681426; rs2681408; rs2715273; rs2681411; rs2715259; rs2715274; rs2681406; rs4315642; rs2715271; rs6786977; rs2681413; rs2681404; rs2681410; rs2715276; rs2001791; rs2715275; rs2715268; rs6808869; rs2681400; rs2681414; rs6804964; rs2715278; rs4308217; rs2332096; rs2715260; rs2681416; rs2681420; rs13074706; rs17203439; rs2681415; rs3792285; rs9836399; rs2681409; rs13095010; rs1915092; rs1915091; rs10511408; rs9848900; rs11921048; rs17203397; rs17281953; rs13064913; rs35187120; rs9880031; rs13075281; rs11713851; rs9799128; rs9860244; rs13090719; rs3792287; rs2715256; rs11922347; rs2715270; rs6781910; rs16832682; rs2715263; rs12495492; rs3804588; rs2715258; rs17203418; rs2715277; rs2001750; rs9282643; rs2715257; rs13082681; rs16832688; rs2254911; rs16832684; rs9872483; rs13090103; rs4678186; rs16832687; rs9289187; rs2254909; rs11712647; rs11575855; rs35276006; rs34865701; rs34080512; rs34158795; rs12330615; rs10622189; rs10620302; rs5852292; rs36226545; rs10561530; rs35919036; rs10711632; rs9282647; rs9859708; rs9282645; rs36107436; rs4678194; rs10710310; rs2681405; rs36038203; rs10582753; rs5852291; rs11272713; rs35956394; rs35078137; rs11425812; rs2681412; rs6798227; rs41271423; rs35084274; rs16832666; rs36082374; rs36226551; rs34259868; rs1915089; rs35826672; rs5852290; rs34076269; rs34974842; rs34263779; rs35891398; rs34331291; rs7626829; rs35061302; rs9839555; rs11375248; rs35598890; rs11441404; rs9815492; rs2255017; rs34902179; rs6778942; rs35010283; rs34647267; rs1915090; rs36226874; rs34420369; rs36226553; rs34027270; rs12106776; rs41271425; rs34824004; rs36226548; rs35479648; rs3828358; rs10580127; rs2681407; rs1806623; rs34652460; rs35736887; rs35819494; rs36226549; rs35139209; rs28495824; rs11304672; rs35742296; rs34693048; rs10576484; rs2681421; rs35815615; rs34141864; rs13087981; rs7612850; rs1915088; rs3792286; rs36226875; rs2715255; rs34365367; rs4048621; rs35938587; rs34972450; rs35699129; rs4453794; rs35190602; rs34861031; rs35582595; rs5852289; rs10704212; rs3804589; rs34269845; rs28715970; rs10704317; rs2681418; rs2715269; rs11341158; rs35060876; rs2681399; rs13320942; rs5852293; rs4440072; rs10703820; rs13091051; rs2255214; rs2262495; rs2681401; rs2681402; rs2681403; rs2681423; rs2681424; rs2681425; rs2715265; rs2715266; rs2715267; rs2715272; rs2946792; rs6438696; rs9879600

# Macromolecular_Interacting_Partner_41_General_References:
7694153; 7694363; 11162656; 7541777; 7527824; 7520767

# Macromolecular_Interacting_Partner_41_References:
12603604

# Macromolecular_Interacting_Partner_42_ID:
7850

# Macromolecular_Interacting_Partner_42_Name:
Neuron-specific protein family member 1

# Macromolecular_Interacting_Partner_42_Synonyms:
Brain neuron cytoplasmic protein 1

# Macromolecular_Interacting_Partner_42_Gene_Name:
NSG1

# Macromolecular_Interacting_Partner_42_Protein_Sequence:
>Neuronspecific protein family member 1
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGK
ARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKN
TQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEA
AEKSA

# Macromolecular_Interacting_Partner_42_Number_of_Residues:
185

# Macromolecular_Interacting_Partner_42_Molecular_Weight:
20913

# Macromolecular_Interacting_Partner_42_Theoretical_pI:
5.40

# Macromolecular_Interacting_Partner_42_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  G-protein-coupled receptor binding
Function:  dopamine receptor binding
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  dopamine receptor signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_42_General_Function:
Not Available

# Macromolecular_Interacting_Partner_42_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_42_Pathway:
Not Available

# Macromolecular_Interacting_Partner_42_Reaction:
Not Available

# Macromolecular_Interacting_Partner_42_Pfam_Domain_Function:
PF06387:Calcyon

# Macromolecular_Interacting_Partner_42_Signals:
None

# Macromolecular_Interacting_Partner_42_Transmembrane_Regions:
83-103

# Macromolecular_Interacting_Partner_42_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_42_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_42_GenBank_ID_Protein:
190261

# Macromolecular_Interacting_Partner_42_SwissProt_ID:
NSG1_HUMAN (P42857)

# Macromolecular_Interacting_Partner_42_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_42_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_42_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_42_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_42_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_42_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_42_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_42_Gene_Sequence:
>558 bp
ATGGTGAAGTTGGGGAACAATTTCGCAGAGAAGGGCACCAAGCAGCCGCTGCTGGAGGAT
GGCTTCGACACCATTCCCCTGATGACGCCCCTCGATGTCAATCAGCTGCAGTTCCCGCCC
CCGGATAAGGTGGTCGTGAAAACTAAGACCGAGTATGAACCTGACCGCAAGAAAGGGAAA
GCACGTCCTCCCCAAATTGCTGAGTTCACCGTCAGCATCACGGAGGGTGTCACCGAGAGG
TTTAAGGTCTCCGTGTTGGTCCTCTTCGCCCTGGCCTTCCTCACCTGCGTCGTCTTCCTG
GTTGTCTACAAGGTGTACAAGTATGACCGCGCCTGCCCCGATGGGTTCGTCCTCAAGAAC
ACCCAGTGCATCCCAGAAGGCTTGGAGAGCTACTACGCGGAGCAAGACTCCAGTGCCCGG
GAGAAATTTTACACAGTCATAAACCACTACAACCTGGCCAAGCAGAGCATCACGCGCTCC
GTATCGCCCTGGATGTCAGTTCTGTCAGAAGAGAAGCTGTCCGAGCAGGAGACTGAAGCG
GCTGAGAAGTCAGCTTAG

# Macromolecular_Interacting_Partner_42_GenBank_ID_Gene:
M98529

# Macromolecular_Interacting_Partner_42_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_42_Locus:
Not Available

# Macromolecular_Interacting_Partner_42_SNPs:
Not Available

# Macromolecular_Interacting_Partner_42_General_References:
9013775

# Macromolecular_Interacting_Partner_42_References:
12806965; 12823590; 12840224; 12840228

# Macromolecular_Interacting_Partner_43_ID:
8000

# Macromolecular_Interacting_Partner_43_Name:
Tumor necrosis factor ligand superfamily member 10

# Macromolecular_Interacting_Partner_43_Synonyms:
TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen

# Macromolecular_Interacting_Partner_43_Gene_Name:
TNFSF10

# Macromolecular_Interacting_Partner_43_Protein_Sequence:
>Tumor necrosis factor ligand superfamily member 10
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

# Macromolecular_Interacting_Partner_43_Number_of_Residues:
281

# Macromolecular_Interacting_Partner_43_Molecular_Weight:
32509

# Macromolecular_Interacting_Partner_43_Theoretical_pI:
7.49

# Macromolecular_Interacting_Partner_43_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_43_General_Function:
Not Available

# Macromolecular_Interacting_Partner_43_Specific_Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis

# Macromolecular_Interacting_Partner_43_Pathway:
Not Available

# Macromolecular_Interacting_Partner_43_Reaction:
Not Available

# Macromolecular_Interacting_Partner_43_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_43_Signals:
1-32

# Macromolecular_Interacting_Partner_43_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_43_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_43_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_43_GenBank_ID_Protein:
1149558

# Macromolecular_Interacting_Partner_43_SwissProt_ID:
TNF10_HUMAN (P50591)

# Macromolecular_Interacting_Partner_43_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_43_Genecard_id:
TNFSF10

# Macromolecular_Interacting_Partner_43_Geneatlas_id:
TNFSF10

# Macromolecular_Interacting_Partner_43_hgnc_id:
HGNC:11925

# Macromolecular_Interacting_Partner_43_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_43_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_43_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_43_Gene_Sequence:
>846 bp
ATGGCTATGATGGAGGTCCAGGGGGGACCCAGCCTGGGACAGACCTGCGTGCTGATCGTG
ATCTTCACAGTGCTCCTGCAGTCTCTCTGTGTGGCTGTAACTTACGTGTACTTTACCAAC
GAGCTGAAGCAGATGCAGGACAAGTACTCCAAAAGTGGCATTGCTTGTTTCTTAAAAGAA
GATGACAGTTATTGGGACCCCAATGACGAAGAGAGTATGAACAGCCCCTGCTGGCAAGTC
AAGTGGCAACTCCGTCAGCTCGTTAGAAAGATGATTTTGAGAACCTCTGAGGAAACCATT
TCTACAGTTCAAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAG
AGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAAC
TCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGG
CATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGG
TTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACA
AAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCCTATA
TTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTAT
TCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTA
ACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTCGGGGCCTTTTTAGTT
GGCTAA

# Macromolecular_Interacting_Partner_43_GenBank_ID_Gene:
U37518

# Macromolecular_Interacting_Partner_43_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_43_Locus:
3q26

# Macromolecular_Interacting_Partner_43_SNPs:
rs16845759; rs6763816; rs1131532; rs1131535; rs1131542; rs17600346; rs1131580; rs1131579; rs1131568; rs3136602; rs231983; rs3136594; rs3181143; rs231981; rs3136587; rs1126161; rs3136608; rs3181139; rs3136597; rs3136601; rs3136598; rs3136606; rs7625589; rs3819773; rs6775921; rs6802485; rs2270418; rs3136599; rs3136600; rs3136603; rs3136596; rs4894559; rs3136589; rs3815496; rs3136607; rs231985; rs2270417; rs1823227; rs231982; rs3136605; rs3181140; rs6784241; rs3136591; rs3136604; rs3136609; rs3774314; rs3181141; rs3821821; rs231987; rs7643953; rs231984; rs231986; rs2241063; rs3774315; rs3181142; rs3136588; rs6802197; rs3774313; rs3774316; rs6801105; rs3136593; rs13076985; rs9865753; rs231979; rs16845780; rs3136592; rs179777; rs3216506; rs9852651; rs9879386; rs3136595; rs3819772; rs231980; rs6777176; rs388515; rs365238; rs9811650; rs9859259; rs9869255; rs3136586; rs3136581; rs9859809; rs432251; rs9811673; rs2860864; rs11720451; rs9811928; rs6783667; rs9859413; rs12696330; rs13089978; rs3136584; rs6807069; rs3136583; rs9873546; rs9869065; rs12488654; rs432821; rs9869551; rs9811646; rs9811639; rs4491934; rs11545817; rs41308132; rs17848014; rs41309772; rs36073561; rs33927039; rs17848022; rs35009921; rs35275903; rs6805054; rs34112044; rs11360845; rs11285482; rs6792667; rs17848027; rs36066568; rs35543813; rs17848018; rs11333712; rs35005998; rs35045041; rs10706597; rs17848023; rs10543824; rs34276385; rs10562888; rs11456314; rs11330298; rs35452093; rs5854474; rs9682939; rs17848024; rs3136590; rs17848019; rs11574670; rs36100137; rs35502466; rs10716802; rs3836481; rs5854475; rs17848021; rs3832247; rs33985142; rs11328072; rs11290814; rs17848025; rs9848845; rs10576110; rs35975099; rs17848015; rs9848839; rs11270839; rs34173943; rs7653559; rs11328471; rs6809850; rs11276567; rs10663063; rs7631904; rs6796310; rs13061406; rs7645745; rs16845791; rs10804846; rs11706116; rs11918343; rs11925997; rs12633330; rs1597086; rs16848052; rs17535790; rs17601515; rs1992868; rs2041691; rs2041692; rs2041693; rs2080199; rs232004; rs233998; rs3136610; rs9817507; rs9854603; rs9855107; rs9855144; rs9880475; rs9880799

# Macromolecular_Interacting_Partner_43_General_References:
8777713; 8663110; 10549288; 10542098; 10485660

# Macromolecular_Interacting_Partner_43_References:
15142888; 16007142; 16096370

# Macromolecular_Interacting_Partner_44_ID:
8452

# Macromolecular_Interacting_Partner_44_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_44_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_44_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_44_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_44_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_44_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_44_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_44_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_44_General_Function:
Not Available

# Macromolecular_Interacting_Partner_44_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_44_Pathway:
Not Available

# Macromolecular_Interacting_Partner_44_Reaction:
Not Available

# Macromolecular_Interacting_Partner_44_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_44_Signals:
1-35

# Macromolecular_Interacting_Partner_44_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_44_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_44_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_44_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_44_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_44_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_44_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_44_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_44_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_44_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_44_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_44_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_44_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_44_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_44_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_44_Locus:
6p21.3

# Macromolecular_Interacting_Partner_44_SNPs:
Not Available

# Macromolecular_Interacting_Partner_44_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_44_References:
12570825; 14512034; 15068815; 15318170

# Macromolecular_Interacting_Partner_45_ID:
7962

# Macromolecular_Interacting_Partner_45_Name:
Trefoil factor 3 precursor

# Macromolecular_Interacting_Partner_45_Synonyms:
Intestinal trefoil factor; hP1.B

# Macromolecular_Interacting_Partner_45_Gene_Name:
TFF3

# Macromolecular_Interacting_Partner_45_Protein_Sequence:
>Trefoil factor 3 precursor
MAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGYPHVTPKECNNRGCCFD
SRIPGVPWCFKPLQEAECTF

# Macromolecular_Interacting_Partner_45_Number_of_Residues:
80

# Macromolecular_Interacting_Partner_45_Molecular_Weight:
8641

# Macromolecular_Interacting_Partner_45_Theoretical_pI:
5.74

# Macromolecular_Interacting_Partner_45_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_45_General_Function:
Not Available

# Macromolecular_Interacting_Partner_45_Specific_Function:
May have a role in promoting cell migration (motogen)

# Macromolecular_Interacting_Partner_45_Pathway:
Not Available

# Macromolecular_Interacting_Partner_45_Reaction:
Not Available

# Macromolecular_Interacting_Partner_45_Pfam_Domain_Function:
PF00088:Trefoil

# Macromolecular_Interacting_Partner_45_Signals:
1-21

# Macromolecular_Interacting_Partner_45_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_45_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_45_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_45_GenBank_ID_Protein:
402483

# Macromolecular_Interacting_Partner_45_SwissProt_ID:
TFF3_HUMAN (Q07654)

# Macromolecular_Interacting_Partner_45_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_45_Genecard_id:
TFF3

# Macromolecular_Interacting_Partner_45_Geneatlas_id:
TFF3

# Macromolecular_Interacting_Partner_45_hgnc_id:
HGNC:11757

# Macromolecular_Interacting_Partner_45_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_45_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_45_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_45_Gene_Sequence:
>243 bp
ATGGCTGCCAGAGCGCTCTGCATGCTGGGGCTGGTCCTGGCCTTGCTGTCCTCCAGCTCT
GCTGAGGAGTACGTGGGCCTGTCTGCAAACCAGTGTGCCGTGCCAGCCAAGGACAGGGTG
GACTGCGGCTACCCCCATGTCACCCCCAAGGAGTGCAACAACCGGGGCTGCTGCTTTGAC
TCCAGGATCCCTGGAGTGCCTTGGTGTTTCAAGCCCCTGCAGGAAGCAGAATGCACCTTC
TGA

# Macromolecular_Interacting_Partner_45_GenBank_ID_Gene:
L15203

# Macromolecular_Interacting_Partner_45_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_45_Locus:
Not Available

# Macromolecular_Interacting_Partner_45_SNPs:
rs11701143; rs533093; rs2236705; rs225361; rs538407; rs225360; rs2236706; rs225362; rs576445; rs225438; rs225437; rs225363; rs9975547; rs11702422; rs11203194; rs225439; rs11203193; rs11203195; rs12626785; rs1788375; rs11546961; rs11546960; rs1804098; rs2282554; rs4920083; rs9976749; rs9975628; rs9754071; rs35033018; rs10687546; rs3838116; rs9975550; rs34315392; rs35770757; rs9980474; rs10084557; rs11203197; rs11701491; rs11909013; rs11910365; rs11910395; rs12483623; rs13046698; rs15661; rs17177760; rs178742; rs186528; rs186529; rs192011; rs225366; rs225367; rs225368; rs225369; rs225414; rs225415; rs225416; rs225417; rs225418; rs225419; rs225420; rs225434; rs225435; rs225436; rs2839485; rs419063; rs480289; rs480449; rs6586305; rs6586306; rs6586307; rs6586308; rs691567; rs692356; rs7275471; rs7276176; rs7277338; rs7277545; rs7280100; rs7281065; rs7281211; rs7282516; rs7283110; rs7283700; rs8128478; rs8130260; rs8130267; rs8131519; rs8133510; rs8133631; rs9981660

# Macromolecular_Interacting_Partner_45_General_References:
8346203; 9070946; 10950923; 10830953; 8454642

# Macromolecular_Interacting_Partner_45_References:
16254517

# Macromolecular_Interacting_Partner_46_ID:
7816

# Macromolecular_Interacting_Partner_46_Name:
Histone deacetylase 1

# Macromolecular_Interacting_Partner_46_Synonyms:
HD1

# Macromolecular_Interacting_Partner_46_Gene_Name:
HDAC1

# Macromolecular_Interacting_Partner_46_Protein_Sequence:
>Histone deacetylase 1
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA

# Macromolecular_Interacting_Partner_46_Number_of_Residues:
482

# Macromolecular_Interacting_Partner_46_Molecular_Weight:
55104

# Macromolecular_Interacting_Partner_46_Theoretical_pI:
5.16

# Macromolecular_Interacting_Partner_46_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  histone deacetylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid deacetylation
Process:  histone deacetylation
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_46_General_Function:
Chromatin structure and dynamics 

# Macromolecular_Interacting_Partner_46_Specific_Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes

# Macromolecular_Interacting_Partner_46_Pathway:
Not Available

# Macromolecular_Interacting_Partner_46_Reaction:
Not Available

# Macromolecular_Interacting_Partner_46_Pfam_Domain_Function:
PF00850:Hist_deacetyl

# Macromolecular_Interacting_Partner_46_Signals:
None

# Macromolecular_Interacting_Partner_46_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_46_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_46_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_46_GenBank_ID_Protein:
1277084

# Macromolecular_Interacting_Partner_46_SwissProt_ID:
HDAC1_HUMAN (Q13547)

# Macromolecular_Interacting_Partner_46_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_46_Genecard_id:
HDAC1

# Macromolecular_Interacting_Partner_46_Geneatlas_id:
HDAC1

# Macromolecular_Interacting_Partner_46_hgnc_id:
HGNC:4852

# Macromolecular_Interacting_Partner_46_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_46_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_46_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_46_Gene_Sequence:
>1449 bp
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA
AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT
TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT
CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT
CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT
GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC
CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC
CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT
GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG
TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG
TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT
TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG
TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA
CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC
GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG
GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT
TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG
AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA
ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC
CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC
TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC
AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC
GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG
TTGGCCTGA

# Macromolecular_Interacting_Partner_46_GenBank_ID_Gene:
U50079

# Macromolecular_Interacting_Partner_46_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_46_Locus:
1p34

# Macromolecular_Interacting_Partner_46_SNPs:
rs8176782; rs6697130; rs7543692; rs16834954; rs16834956; rs16834958; rs16834963; rs16834957; rs12133048; rs17507358; rs12096858; rs17255809; rs690334; rs2127246; rs10914548; rs1741981; rs1140658; rs1140673; rs11541185; rs11541183; rs11541184; rs1140660; rs8176783; rs10914552; rs690332; rs35808493; rs12026405; rs552686; rs7533676; rs6679175; rs34899445; rs7512341; rs10914547; rs10914551; rs12723325; rs552733; rs34315355; rs34267128; rs12758327; rs10914546; rs12734422; rs34371852; rs10652556; rs34065217; rs10465520; rs690520; rs35894142; rs28419695; rs471372; rs35770915; rs34386633; rs552732; rs34447178; rs12727854; rs35678923; rs34021057; rs34742550; rs28372816; rs11589444; rs35790615; rs10465522; rs12022567; rs690006; rs690525; rs2019923; rs34403317; rs7544100; rs9699564; rs35191653; rs35577659; rs35345816; rs10465521; rs34304672; rs36212114; rs11459069; rs36212119; rs36212122; rs36211753; rs35299850; rs36212118; rs36212115; rs36212123; rs36212121; rs36212117; rs12090734; rs36212116; rs34992032; rs35764672; rs1042546; rs10914545; rs11576036; rs11576040; rs11576043; rs11807976; rs11809371; rs12048924; rs8176768; rs8176777; rs8176781

# Macromolecular_Interacting_Partner_46_General_References:
8602529; 8646880; 10487760; 10898795; 10669754; 11602581; 11331609; 11102443; 11427533; 12032081; 12670868; 12493763; 12482978; 12724404; 10904264

# Macromolecular_Interacting_Partner_46_References:
15051827

# Macromolecular_Interacting_Partner_47_ID:
8202

# Macromolecular_Interacting_Partner_47_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_47_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_47_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_47_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_47_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_47_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_47_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_47_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_47_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_47_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_47_Pathway:
Not Available

# Macromolecular_Interacting_Partner_47_Reaction:
Not Available

# Macromolecular_Interacting_Partner_47_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_47_Signals:
None

# Macromolecular_Interacting_Partner_47_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_47_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_47_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_47_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_47_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_47_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_47_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_47_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_47_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_47_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_47_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_47_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_47_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_47_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_47_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_47_Locus:
10q22

# Macromolecular_Interacting_Partner_47_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_47_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_47_References:
12692060; 16541197

# Macromolecular_Interacting_Partner_48_ID:
7934

# Macromolecular_Interacting_Partner_48_Name:
Integrin alpha-11 precursor

# Macromolecular_Interacting_Partner_48_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_48_Gene_Name:
ITGA11

# Macromolecular_Interacting_Partner_48_Protein_Sequence:
>Integrin alpha11 precursor
MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGA
PLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLA
CSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVE
VQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTET
RTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVL
GYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNET
SFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKN
HGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYF
GSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNRFVYNGTLKDSHSYQNA
RFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATG
LQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCK
RSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAV
LLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNG
CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAV
EATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFF
RAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFT
RSSSLSHYEVKLNSSLERYDGIGPPFSCIFRIQNLGLFPIHGIMMKITIPIATRSGNRLL
KLRDFLTDEVANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQE
INFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQ
VPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

# Macromolecular_Interacting_Partner_48_Number_of_Residues:
1189

# Macromolecular_Interacting_Partner_48_Molecular_Weight:
133612

# Macromolecular_Interacting_Partner_48_Theoretical_pI:
6.74

# Macromolecular_Interacting_Partner_48_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  cell-substrate adhesion
Process:  cell-matrix adhesion
Process:  cellular process
Process:  cell adhesion
 ||
>>>
Component:  protein complex
Component:  receptor complex
Component:  integrin complex

# Macromolecular_Interacting_Partner_48_General_Function:
Not Available

# Macromolecular_Interacting_Partner_48_Specific_Function:
Integrin alpha-11/beta-1 is a receptor for collagen

# Macromolecular_Interacting_Partner_48_Pathway:
Not Available

# Macromolecular_Interacting_Partner_48_Reaction:
Not Available

# Macromolecular_Interacting_Partner_48_Pfam_Domain_Function:
PF01839:FG-GAP;
PF08441:Integrin_alpha2;
PF00092:VWA

# Macromolecular_Interacting_Partner_48_Signals:
1-22

# Macromolecular_Interacting_Partner_48_Transmembrane_Regions:
1143-1165

# Macromolecular_Interacting_Partner_48_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_48_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_48_GenBank_ID_Protein:
6013141

# Macromolecular_Interacting_Partner_48_SwissProt_ID:
ITA11_HUMAN (Q9UKX5)

# Macromolecular_Interacting_Partner_48_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_48_Genecard_id:
ITGA11

# Macromolecular_Interacting_Partner_48_Geneatlas_id:
ITGA11

# Macromolecular_Interacting_Partner_48_hgnc_id:
HGNC:6136

# Macromolecular_Interacting_Partner_48_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_48_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_48_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Macromolecular_Interacting_Partner_48_Gene_Sequence:
>3570 bp
ATGGACCTGCCCAGGGGCCTGGTGGTGGCCTGGGCGCTCAGCCTGTGGCCAGGGTTCACG
GACACCTTCAACATGGACACCAGGAAGCCCCGGGTCATCCCTGGCTCCAGGACCGCCTTC
TTTGGCTACACAGTGCAGCAGCACGACATCAGTGGCAATAAGTGGCTGGTCGTGGGCGCC
CCACTGGAAACCAATGGCTACCAGAAGACGGGAGACGTGTACAAGTGTCCAGTGATCCAC
GGGAACTGCACCAAACTCAACCTGGGAAGGGTCACCCTGTCCAACGTGTCCGAGCGGAAA
GACAACATGCGCCTCGGCCTTAGTCTCGCCACCAACCCCAAGGACAACAGCTTCCTGGCC
TGCAGCCCCCTCTGGTCTCATGAGTGTGGGAGCTCCTACTACACCACAGGGATGTGTTCA
AGAGTCAACTCCAACTTCAGGTTCTCCAAGACCGTGGCCCCAGCTCTCCAAAGGTGCCAG
ACCTACATGGACATCGTCATTGTCCTGGATGGCTCCAACAGCATCTACCCCTGGGTGGAG
GTTCAGCACTTCCTCATCAACATCCTGAAAAAGTTTTACATTGGCCCAGGGCAGATCCAG
GTTGGAGTTGTGCAGTATGGCGAAGATGTGGTGCATGAGTTTCACCTCAATGACTACAGG
TCTGTAAAAGATGTGGTGGAAGCTGCCAGCCACATTGAGCAGAGAGGAGGAACAGAGACC
CGGACGGCATTTGGCATTGAATTTGCACGCTCAGAGGCTTTCCAGAAGGGTGGAAGGAAA
GGAGCCAAGAAGGTGATGATTGTCATCACAGATGGGGAGTCCCACGACAGCCCAGACCTG
GAGAAGGTGATCCAGCAAAGCGAAAGAGACAACGTAACAAGATATGCGGTGGCCGTCCTG
GGCTACTACAACCGCAGGGGGATCAATCCAGAAACTTTTCTAAATGAAATCAAATACATC
GCCAGTGACCCTGATGACAAGCACTTCTTCAATGTCACTGATGAGGCTGCCTTGAAGGAC
ATTGTCGATGCCCTGGGGGACAGAATCTTCAGCCTGGAAGGCACCAACAAGAACGAGACC
TCCTTTGGGCTGGAGATGTCACAGACGGGCTTTTCCTCGCACGTGGTGGAGGATGGGGTT
CTGCTGGGAGCCGTCGGTGCCTATGACTGGAATGGAGCTGTGCTAAAGGAGACGAGTGCC
GGGAAGGTCATTCCTCTCCGCGAGTCCTACCTGAAAGAGTTCCCCGAGGAGCTCAAGAAC
CATGGTGCATACCTGGGGTACACAGTCACATCGGTCGTGTCCTCCAGGCAGGGGCGAGTG
TACGTGGCCGGAGCCCCCCGGTTCAACCACACGGGCAAGGTCATCCTGTTCACCATGCAC
AACAACCGGAGCCTCACCATCCACCAGGCTATGCGGGGCCAGCAGATAGGCTCTTACTTT
GGGAGTGAAATCACCTCGGTGGACATCGACGGCGACGGCGTGACTGATGTCCTGCTGGTG
GGCGCACCCATGTACTTCAACGAGGGCCGTGAGCGAGGCAAGGTGTACGTCTATGAGCTG
AGACAGAACCGGTTTGTTTATAACGGAACGCTAAAGGATTCACACAGTTACCAGAATGCC
CGATTTGGGTCCTCCATTGCCTCAGTTCGAGACCTCAACCAGGATTCCTACAATGACGTG
GTGGTGGGAGCCCCCCTGGAGGACAACCACGCAGGAGCCATCTACATCTTCCACGGCTTC
CGAGGCAGCATCCTGAAGACACCTAAGCAGAGAATCACAGCCTCAGAGCTGGCTACCGGC
CTCCAGTATTTTGGCTGCAGCATCCACGGGCAATTGGACCTCAATGAGGATGGGCTCATC
GACCTGGCAGTGGGAGCCCTTGGCAACGCTGTGATTCTGTGGTCCCGCCCAGTGGTTCAG
ATCAATGCCAGCCTCCACTTTGAGCCATCCAAGATCAACATCTTCCACAGAGACTGCAAG
CGCAGTGGCAGGGATGCCACCTGCCTGGCCGCCTTCCTCTGCTTCACGCCCATCTTCCTG
GCACCCCATTTCCAAACAACAACTGTTGGCATCAGATACAACGCCACCATGGATGAGAGG
CGGTATACACCGAGGGCCCACCTGGACGAGGGCGGGGACCGATTCACCAACAGAGCCGTA
CTGCTCTCCTCCGGCCAGGAGCTCTGTGAGCGGATCAACTTCCATGTCCTGGACACTGCT
GACTACGTGAAGCCAGTGACCTTCTCAGTCGAGTATTCCCTGGAGGACCCTGACCATGGC
CCCATGCTGGACGACGGCTGGCCCACCACTCTCAGAGTCTCGGTGCCCTTCTGGAACGGC
TGCAATGAGGATGAGCACTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCC
ACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGACTGCTCCGCATAC
ACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTG
GAGGCCACACTGGAGAACAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAG
TCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGACGGTAGCATTGAG
TGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTC
CGGGCCAAGGCCAAGGTGGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTA
CACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCGGGACAGCACCAAG
GAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACC
AGGAGCAGCAGCCTGAGCCACTACGAGGTCAAGCTCAACAGCTCGCTGGAGAGATACGAT
GGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGGCTTGTTCCCCATC
CACGGGATTATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTG
AAGCTGAGGGACTTCCTCACGGACGAGGTAGCGAACACGTCCTGTAACATCTGGGGCAAT
AGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGCTCCACAGCTGAAT
CACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAA
ATCAATTTCCATCTACTGGGGAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAA
TCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAGCCCCTTCATCTTC
CGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAG
GTCCCCATCTGGATCATTGTAGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTG
GTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAGGAGGGAGCCTGGT
CTGGACCCCACCCCCAAAGTGCTGGAGTGA

# Macromolecular_Interacting_Partner_48_GenBank_ID_Gene:
AF109681

# Macromolecular_Interacting_Partner_48_Chromosome_Location:
Chromosome:15

# Macromolecular_Interacting_Partner_48_Locus:
15q23

# Macromolecular_Interacting_Partner_48_SNPs:
rs2271725; rs4777035; rs2306022; rs2306024; rs7168069; rs3736493; rs2271724; rs2306023; rs9302249; rs2292745; rs2271728; rs2271720; rs12907890; rs11629460; rs3736494; rs1122247; rs12148843; rs3817330; rs10851784; rs754399; rs898586; rs967565; rs2279101; rs1460644; rs898581; rs8041260; rs11072020; rs7176267; rs4617801; rs8039349; rs3784351; rs12443350; rs4238412; rs8038368; rs8035431; rs8036698; rs11630897; rs7174755; rs1476222; rs3784350; rs898580; rs970264; rs895137; rs11629808; rs750158; rs8035990; rs7170808; rs2306021; rs8040014; rs11635082; rs7170403; rs4776398; rs967566; rs11630977; rs6494735; rs8043127; rs7176011; rs7169854; rs7179228; rs7172210; rs4777049; rs12595773; rs11072015; rs12050670; rs11857985; rs6494736; rs8036939; rs1007617; rs11631030; rs4777033; rs7162189; rs9920271; rs7182849; rs11858032; rs895135; rs11072016; rs1115528; rs4777051; rs11857615; rs4777037; rs3736491; rs898590; rs4777048; rs11632400; rs8024010; rs748892; rs8043152; rs964691; rs4408487; rs9972560; rs5016065; rs11072021; rs11634026; rs12441197; rs1982592; rs4776397; rs12442156; rs4777036; rs898579; rs7176145; rs11855593; rs2415008; rs898584; rs11637286; rs3784345; rs7180218; rs2415001; rs11853855; rs7165618; rs11634100; rs2306012; rs4776402; rs11853718; rs1077731; rs11637293; rs2271723; rs12591673; rs7176173; rs17252387; rs8029230; rs11630284; rs11072010; rs4517737; rs8025985; rs3816612; rs16952065; rs11630928; rs6494743; rs11639240; rs11638575; rs8029838; rs1516871; rs2061564; rs7162991; rs2415000; rs3784346; rs4777041; rs7174916; rs4777046; rs6494732; rs16952005; rs4777039; rs4356422; rs7171871; rs11072014; rs16951961; rs2306013; rs2271722; rs4776404; rs8029113; rs4477640; rs16951767; rs7179347; rs7163918; rs8036876; rs1380881; rs7169899; rs1460645; rs11858758; rs11637346; rs16952001; rs4500670; rs4777034; rs10162690; rs16952059; rs11072011; rs7161791; rs11633421; rs1350733; rs6494742; rs4777040; rs11636019; rs1380883; rs8029162; rs7183704; rs8028967; rs11857338; rs2169213; rs16951778; rs2271721; rs4419008; rs11856183; rs8043262; rs1125721; rs16951774; rs9672310; rs7161871; rs898577; rs2415006; rs11637411; rs8042664; rs748891; rs16951954; rs4238414; rs11072012; rs1075991; rs3736495; rs7497049; rs11858293; rs4776405; rs8041788; rs8042999; rs2415009; rs4776394; rs16952036; rs11633614; rs2415002; rs4776399; rs3784334; rs4777042; rs11635699; rs898582; rs898589; rs6494734; rs1516869; rs3784347; rs7182350; rs2306020; rs2169214; rs11630443; rs10851785; rs7167822; rs2125998; rs16951777; rs2306015; rs11072009; rs7168991; rs2415005; rs4777047; rs16951841; rs8042862; rs898576; rs16952052; rs11072013; rs12595779; rs8028971; rs17318470; rs3784348; rs11634499; rs4776396; rs7168997; rs11852504; rs1824478; rs1020842; rs2306018; rs1813565; rs11635643; rs10851786; rs1319223; rs11072008; rs2414994; rs7164150; rs4375610; rs12440936; rs12592461; rs11637463; rs3784335; rs6494731; rs4776403; rs2306014; rs8030538; rs8030178; rs898593; rs748971; rs10400907; rs7179545; rs16951819; rs895136; rs6494738; rs2306019; rs11636813; rs8042710; rs11855998; rs1380882; rs16951816; rs12591421; rs2306025; rs4777045; rs11856272; rs3784349; rs12914609; rs10851787; rs11634149; rs2306017; rs16951746; rs7164335; rs10444851; rs2415007; rs3784336; rs12441412; rs7179598; rs1020841; rs4776400; rs1077730; rs11858012; rs1563894; rs2305078; rs11632266; rs2415003; rs4536409; rs898575; rs11635776; rs1007615; rs16952041; rs11632656; rs1975874; rs11635712; rs11072018; rs8042332; rs1124577; rs898587; rs8030943; rs1516870; rs2414996; rs7178537; rs2125999; rs4299097; rs2125997; rs6494733; rs17320635; rs16951999; rs7173365; rs16951750; rs2414998; rs967567; rs1841405; rs4777038; rs4777050; rs2306016; rs2899736; rs898583; rs16951765; rs8031003; rs11858671; rs3784342; rs2125996; rs8039820; rs4605110; rs7165305; rs7173815; rs4776395; rs898594; rs1841404; rs11637375; rs16952056; rs898574; rs9783729; rs4454914; rs716379; rs6494740; rs3784344; rs2414997; rs8031936; rs7173564; rs11852717; rs1533469; rs2271726; rs3816611; rs16951835; rs7164172; rs1542473; rs2899735; rs2414995; rs898592; rs7403417; rs7176339; rs12443183; rs8029452; rs17266192; rs11630750; rs7496244; rs7181198; rs7166628; rs898585; rs967564; rs3784337; rs6494744; rs1470415; rs4426302; rs7176148; rs1445024; rs12915814; rs733574; rs3084584; rs12591263; rs34645431; rs28675010; rs1106706; rs28832076; rs12912332; rs28820967; rs34407903; rs28632038; rs33910742; rs34456821; rs1237911; rs4363820; rs11072017; rs2100003; rs1239019; rs16951868; rs35452602; rs4318156; rs28479079; rs35079218; rs8023993; rs11858232; rs34701287; rs8038774; rs28430608; rs28497433; rs34739598; rs35400299; rs11855056; rs10580084; rs12595520; rs11274413; rs7165603; rs10647873; rs4776401; rs9672383; rs8029186; rs35400442; rs34098259; rs2415004; rs34583165; rs28685790; rs11858237; rs11438057; rs28453743; rs4567653; rs1460643; rs28493712; rs28469639; rs34781411; rs5813485; rs10584732; rs10584731; rs34351994; rs35139299; rs35688044; rs5813489; rs12441591; rs8024015; rs35562050; rs13329519; rs34470974; rs35619732; rs3084640; rs34903160; rs34360809; rs34899976; rs28415078; rs33913338; rs5813482; rs34637773; rs11072007; rs8028080; rs11632946; rs35860391; rs4238413; rs35808090; rs8040548; rs28584322; rs7169698; rs28449432; rs898578; rs28620930; rs1077732; rs8028747; rs34800998; rs28517670; rs35874078; rs7164238; rs36078545; rs3084639; rs35280222; rs35325204; rs5813486; rs2271729; rs34438637; rs34704980; rs10574703; rs4777044; rs34297295; rs28669764; rs34222567; rs28695547; rs34278524; rs3084641; rs35584050; rs10618087; rs16952015; rs1542474; rs34822014; rs28740972; rs6494739; rs12591448; rs8032290; rs5813483; rs12898972; rs7174384; rs28442582; rs12902013; rs36216483; rs11858258; rs34660674; rs11632959; rs34338447; rs4777043; rs10565230; rs3837691; rs11858261; rs1824479; rs11854515; rs898591; rs16952019; rs28884935; rs34559605; rs2271727; rs34726895; rs28634234; rs35970041; rs898595; rs11072006; rs34588195; rs12593835; rs28434753; rs10580840; rs28522005; rs8029011; rs16951779; rs6494741; rs34224367; rs34119426; rs12914851; rs12442960; rs11424476; rs11428988; rs28401309; rs12912832; rs2084033; rs34918989; rs35499724; rs12899284; rs7181259; rs28665430; rs35325769; rs6145615; rs34136572; rs28363966; rs11638124; rs28394587; rs34001731; rs1870646; rs34840804; rs5813492; rs5813488; rs35178663; rs2414999; rs28711817; rs9630432; rs28713626; rs1996361; rs35284300; rs11380346; rs16951820; rs33914028; rs28436003; rs5813487; rs4533222; rs35094508; rs35035217; rs3837690; rs12441877; rs28768146; rs34640987; rs35071996; rs35051383; rs28672317; rs34079664; rs28491879; rs11072005; rs28735807; rs28613431; rs12050550; rs3084605; rs28723505; rs9672395; rs12593553; rs35634579; rs11853861; rs35666288; rs10569599; rs35025145; rs35900942; rs28591120; rs34501075; rs11855108; rs12592187; rs36096585; rs3084602; rs16952017; rs28461989; rs28460512; rs35426923; rs35952951; rs28566900; rs10567819; rs4402499; rs34030877; rs34618079; rs5813491; rs7177709; rs898588; rs28404208; rs7174690; rs35904581; rs12593571; rs4517738; rs28480552; rs34220669; rs35455543; rs28592619; rs36112980; rs34122553; rs7177979; rs5813484; rs34788905; rs12908869; rs35563812; rs28683053; rs34467259; rs34009804; rs10444850; rs11072002; rs11072003; rs11072004; rs11072022; rs11072025; rs12438807; rs12442355; rs12593610; rs12593620; rs12593625; rs12593626; rs12593634; rs12594282; rs12595056; rs12899005; rs12904888; rs12906388; rs12913105; rs12913467; rs12913696; rs12914614; rs1373699; rs1445022; rs1445023; rs2415015; rs2415016; rs2415017; rs2415018; rs28452190; rs2899738; rs34702468; rs35906516; rs4280184; rs4410025; rs4999936; rs4999937; rs6494730; rs6494745; rs7162348; rs7163188; rs7167102; rs7167465; rs7168990; rs7172173; rs7172500; rs8043066; rs8043202; rs920922; rs920923; rs920924

# Macromolecular_Interacting_Partner_48_General_References:
10486209; 10464311

# Macromolecular_Interacting_Partner_48_References:
12692060; 14566963; 14592659; 16019930

# Macromolecular_Interacting_Partner_49_ID:
8408

# Macromolecular_Interacting_Partner_49_Name:
Zinc finger protein 148

# Macromolecular_Interacting_Partner_49_Synonyms:
Zinc finger DNA-binding protein 89; Transcription factor ZBP-89

# Macromolecular_Interacting_Partner_49_Gene_Name:
ZNF148

# Macromolecular_Interacting_Partner_49_Protein_Sequence:
>Zinc finger protein 148
MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA
DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF
TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF
RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY
HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED
SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYM
VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEES
KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA
SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEV
LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKAN
MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR
SGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV
HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAG
MTSSPDATTGQTFG

# Macromolecular_Interacting_Partner_49_Number_of_Residues:
794

# Macromolecular_Interacting_Partner_49_Molecular_Weight:
88977

# Macromolecular_Interacting_Partner_49_Theoretical_pI:
6.46

# Macromolecular_Interacting_Partner_49_GO_Classification:
>>>
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_49_General_Function:
Not Available

# Macromolecular_Interacting_Partner_49_Specific_Function:
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes

# Macromolecular_Interacting_Partner_49_Pathway:
Not Available

# Macromolecular_Interacting_Partner_49_Reaction:
Not Available

# Macromolecular_Interacting_Partner_49_Pfam_Domain_Function:
PF00096:zf-C2H2

# Macromolecular_Interacting_Partner_49_Signals:
None

# Macromolecular_Interacting_Partner_49_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_49_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_49_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_49_GenBank_ID_Protein:
2828110

# Macromolecular_Interacting_Partner_49_SwissProt_ID:
ZN148_HUMAN (Q9UQR1)

# Macromolecular_Interacting_Partner_49_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_49_Genecard_id:
ZNF148

# Macromolecular_Interacting_Partner_49_Geneatlas_id:
ZNF148

# Macromolecular_Interacting_Partner_49_hgnc_id:
HGNC:12933

# Macromolecular_Interacting_Partner_49_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_49_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_49_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_49_Gene_Sequence:
>2385 bp
ATGAACATTGACGACAAACTGGAAGGATTGTTTCTTAAATGTGGCGGCATAGACGAAATG
CAGTCTTCCAGGACAATGGTTGTAATGGGTGGAGTGTCTGGCCAGTCTACTGTGTCTGGA
GAGCTACAGGATTCAGTACTTCAAGATCGAAGTATGCCTCACCAGGAGATCCTTGCTGCA
GATGAAGTGTTACAAGAAAGTGAAATGAGACAACAGGATATGATATCACATGATGAACTC
ATGGTCCATGAGGAGACAGTGAAAAATGATGAAGAGCAGATGGAAACACATGAAAGACTT
CCTCAAGGACTACAGTATGCACTTAATGTCCCTATAAGCGTAAAGCAGGAAATTACTTTT
ACTGATGTATCTGAGCAACTGATGAGAGACAAAAAACAAATCAGAGAGCCAGTAGACTTA
CAGAAAAAGAAGAAGCGGAAACAACGTTCTCCCGCAAAAATCCTTACAATAAATGAGGAT
GGATCACTTGGTTTGAAAACCCCTAAATCTCACGTTTGTGAGCACTGCAATGCTGCCTTT
AGAACGAACTATCACTTACAGAGACATGTCTTCATTCATACAGGTGAAAAACCATTTCAA
TGTAGTCAATGTGACATGCGTTTCATACAGAAGTACCTGCTTCAGAGACATGAGAAGATT
CATACTGGTGAAAAACCATTTCGCTGTGATGAATGTGGTATGAGATTCATACAAAAATAT
CATATGGAAAGGCATAAGAGAACTCATAGTGGAGAAAAACCTTACCAGTGTGAATACTGT
TTACAGTATTTTTCCAGAACAGATCGTGTATTGAAACATAAACGTATGTGCCATGAAAAT
CATGACAAAAAACTAAATAGATGTGCCATCAAAGGTGGCCTTCTGACATCTGAGGAAGAT
TCTGGCTTTTCTACATCACCAAAAGACAACTCACTGCCAAAAAAGAAAAGGCAGAAAACG
GAGAAAAAATCATCTGGAATGGACAAAGAGAGTGCTTTGGACAAATCTGACCTGAAAAAA
GACAAAAATGATTACTTGCCTCTTTATTCTTCAAGTACTAAAGTAAAAGATGAGTATATG
GTTGCAGAATATGCTGTTGAAATGCCACATTCGTCAGTTGGGGGCTCGCATTTAGAAGAT
GCGTCAGGAGAAATACACCCACCTAAGTTAGTTCTCAAAAAAATTAATAGTAAGAGAAGT
CTGAAACAGCCACTGGAGCAAAATCAAACAATTTCACCTTTATCCACATATGAAGAGAGC
AAAGTTTCAAAGTATGCTTTTGAACTTGTGGATAAACAGGCTTTACTGGACTCAGAAGGC
AATGCTGACATTGATCAGGTTGATAATTTGCAGGAGGGGCCCAGTAAACCTGTGCATAGT
AGTACTAATTATGATGATGCCATGCAGTTTTTGAAGAAGAAGCGGTATCTTCAAGCAGCA
AGTAACAACAGCAGGGAATATGCGCTGAATGTGGGTACCATAGCTTCTCAGCCTTCTGTA
ACACAAGCAGCTGTGGCAAGTGTCATTGATGAAAGTACCACGGCATCCATATTAGAGTCA
CAGGCACTGAATGTGGAGATTAAGAGTAATCATGACAAAAATGTTATTCCAGATGAGGTA
CTGCAGACTCTGTTGGATCATTATTCCCACAAAGCTAATGGACAGCATGAGATATCCTTC
AGTGTTGCAGATACTGAAGTGACTTCTAGCATATCAATAAATTCTTCAGAAGTACCAGAG
GTCACCCCGTCAGAGAATGTTGGATCAAGCTCCCAAGCATCCTCATCAGATAAAGCCAAC
ATGTTGCAGGAATACTCCAAGTTTCTGCAGCAGGCTTTGGACAGAACTAGCCAAAATGAT
GCCTATTTGAATAGCCCGAGCCTTAACTTTGTGACTGATAACCAGACCCTCCCAAATCAG
CCAGCATTCTCTTCCATAGACAAGCAGGTCTATGCCACCATGCCCATCAATAGCTTTCGA
TCAGGAATGAATTCTCCACTAAGAACAACTCCAGATAAGTCCCACTTTGGACTAATAGTT
GGTGATTCACAGCACTCATTTCCCTTTTCAGGTGATGAGACAAACCATGCTTCTGCCACA
TCAACACAGGACTTTCTGGATCAAGTGACTTCTCAGAAGAAAGCTGAGGCCCAGCCTGTC
CACCAAGCTTACCAAATGAGCTCCTTTGAACAGCCCTTCCGTGCTCCCTATCATGGATCA
AGAGCTGGAATAGCTACTCAATTTAGCACTGCCAATGGACAGGTGAACCTTCGGGGACCA
GGGACAAGTGCTGAATTTTCAGAATTTCCCTTGGTGAATGTAAATGATAATAGAGCTGGG
ATGACATCTTCACCTGATGCCACAACTGGCCAGACTTTTGGCTAA

# Macromolecular_Interacting_Partner_49_GenBank_ID_Gene:
AF039019

# Macromolecular_Interacting_Partner_49_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_49_Locus:
3q21

# Macromolecular_Interacting_Partner_49_SNPs:
rs1053737; rs1053738; rs12695453; rs9877328; rs7609684; rs4679387; rs6438898; rs12637629; rs7643632; rs2333197; rs12485473; rs4679385; rs9882663; rs6438895; rs9855330; rs9857500; rs6804933; rs6438896; rs11711167; rs6787332; rs6780042; rs9835788; rs9851008; rs9844360; rs9289250; rs9849383; rs6438897; rs10048926; rs4303833; rs4386447; rs9289251; rs6767136; rs4679167; rs9851588; rs10512647; rs7609964; rs6808088; rs6808899; rs4508729; rs2333199; rs4679384; rs16836745; rs13086821; rs4679168; rs7609696; rs9883247; rs6807980; rs13098926; rs13074986; rs6773670; rs7620704; rs9853337; rs11708180; rs7647548; rs10049453; rs4679383; rs9814274; rs7431183; rs9289249; rs16836746; rs4679388; rs9855686; rs7647459; rs6792293; rs7635104; rs9815953; rs12695451; rs4679390; rs6787226; rs7620790; rs9880725; rs2333198; rs12636970; rs1982491; rs12487071; rs2333200; rs7642600; rs1850506; rs987956; rs2333196; rs1999921; rs7615139; rs9857356; rs9289245; rs4679163; rs2168237; rs9870428; rs1338543; rs7652521; rs2011442; rs1455050; rs9858110; rs4450756; rs1961457; rs9850300; rs6772299; rs6438885; rs7615040; rs2039718; rs4679162; rs1975760; rs1999919; rs7638240; rs6781706; rs4679373; rs4679382; rs17330607; rs7612285; rs9858524; rs6800532; rs9858336; rs9882766; rs6807163; rs1349972; rs1607238; rs2066042; rs6438892; rs1455049; rs6438887; rs9820507; rs1999920; rs4679380; rs7615035; rs4679160; rs1455051; rs9840737; rs4679161; rs6438893; rs7650116; rs6784650; rs4679375; rs1869673; rs2168238; rs9879936; rs7619480; rs11914990; rs17264366; rs7623450; rs9859543; rs9832629; rs9816308; rs6438890; rs6438888; rs4416340; rs6784613; rs11709450; rs9862499; rs7637986; rs12330741; rs9816044; rs9866637; rs13061044; rs9818938; rs16836696; rs4679378; rs13077440; rs1823937; rs6792807; rs1574955; rs13078585; rs12490924; rs12695449; rs17330495; rs9870577; rs2061085; rs6810205; rs9840709; rs9870660; rs16836673; rs11915021; rs9839414; rs4679379; rs6438886; rs13062873; rs9856122; rs9832089; rs16836687; rs1817183; rs2009385; rs9860377; rs9814573; rs9826108; rs9852389; rs6438889; rs897323; rs9876342; rs4679376; rs2124189; rs13063765; rs510232; rs13090865; rs9857232; rs35950048; rs28728401; rs4679389; rs9713555; rs34067371; rs34621131; rs13074969; rs35430872; rs11434686; rs6764137; rs34184012; rs34931859; rs35452665; rs34179909; rs2168240; rs9859881; rs1060677; rs13092518; rs35441943; rs35694328; rs28884867; rs35820239; rs35695528; rs28727333; rs34316893; rs35337513; rs10662690; rs34843090; rs6808922; rs11434687; rs36092446; rs35562223; rs36126015; rs10621610; rs35548970; rs6783614; rs35419054; rs13094075; rs36070409; rs35145293; rs35879999; rs34896111; rs11719317; rs35589189; rs11719535; rs35672726; rs35233433; rs13073553; rs12634008; rs13320826; rs35916755; rs4300967; rs35258657; rs35210971; rs34288521; rs7428004; rs35144076; rs13094901; rs2877871; rs35810148; rs9861092; rs9825838; rs10663485; rs34003819; rs35637240; rs10565589; rs34214611; rs1982492; rs9842209; rs11316937; rs11303817; rs11377888; rs9840035; rs13097753; rs35424904; rs34087588; rs11274826; rs10706935; rs34792480; rs10625384; rs12639336; rs35915240; rs3030724; rs13065790; rs11452294; rs34826461; rs11274143; rs28538016; rs35755172; rs11383689; rs33978796; rs35351859; rs11348713; rs35989620; rs28464853; rs11375767; rs34770537; rs11425391; rs35024355; rs11344103; rs34630272; rs34414126; rs35656114; rs13314322; rs35800258; rs9289248; rs35340375; rs36032396; rs35831798; rs35801712; rs35838836; rs35470190; rs35673839; rs35398611; rs35659393; rs4679386; rs9824581; rs12493676; rs13079615; rs34332871; rs34370274; rs35674201; rs35756256; rs34017965; rs35645862; rs34188004; rs11420317; rs10709074; rs6768561; rs11391406; rs10627611; rs34797795; rs13100611; rs35734762; rs12630804; rs34921303; rs35917851; rs11312460; rs34104281; rs35524011; rs35668096; rs4679377; rs10576530; rs34515779; rs10709075; rs11373915; rs33942993; rs4679374; rs10659643; rs34918292; rs36077089; rs13091801; rs34739205; rs35068331; rs2168239; rs34424875; rs28416214; rs3030721; rs9868362; rs34338575; rs12485955; rs34418638; rs35379059; rs35758679; rs11925389; rs35297197; rs34401724; rs35343498; rs28521594; rs34093385; rs35404141; rs11278645; rs10613321; rs35304183; rs34388942; rs34880801; rs35679388; rs7624547; rs7633384; rs35018622; rs34892309; rs11463727; rs35108764; rs34381138; rs11435462; rs35986994; rs34643582; rs34168423; rs10704518; rs9816482; rs34592713; rs34437717; rs9819774; rs35142216; rs6791415; rs5852454; rs36206841; rs9839400; rs28375751; rs1960105; rs11425970; rs10567631; rs2333195; rs13091911; rs13327822; rs10689484; rs34024592; rs9813844; rs10621538; rs35704064; rs10565566; rs7612355; rs36003000; rs10712959; rs9917630; rs34760585; rs9831954; rs10623312; rs28530557; rs34469920; rs13071312; rs28656952; rs34440978; rs10703884; rs2061086; rs35270198; rs11385803; rs34533587; rs34364842; rs36051348; rs7646487; rs7625154; rs9867262; rs5852453; rs35106221; rs13060274; rs34456399; rs35502723; rs9834163; rs1988178; rs35415615; rs11456933; rs34772918; rs33910439; rs10703127; rs34943558; rs5852452; rs34995896; rs35923292; rs34847960; rs34055193; rs34037323; rs35524024; rs35749016; rs13074468; rs34788281; rs35531442; rs11425971; rs11370338; rs34560368; rs11391775; rs9854879; rs35313913; rs35844943; rs11441831; rs34133011; rs11425236; rs35145256; rs13323832; rs34632630; rs36112318; rs1046752; rs11924106; rs13573; rs2292520; rs2292803; rs4679169; rs4679372; rs592528; rs592559; rs6801477; rs7623968; rs936078; rs936079; rs936080; rs9840783

# Macromolecular_Interacting_Partner_49_General_References:
9457682; 10359087

# Macromolecular_Interacting_Partner_49_References:
12622418

End of HMDB00039

Beginning of HMDB00042
# Accession_No:
HMDB00042

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-23 12:29:02

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Acetic acid

# Description:
Acetic acid is one of the simplest carboxylic acids. It is an important chemical reagent and industrial chemical that is used in the production of plastic soft drink bottles, photographic film; and polyvinyl acetate for wood glue, as well as many synthetic fibres and fabrics. In households diluted acetic acid is often used as a cleaning agent. In the food industry acetic acid is used as an acidity regulator. The acetyl group, derived from acetic acid, is fundamental to the biochemistry of virtually all forms of life. When bound to coenzyme A it is central to the metabolism of carbohydrates and fats. However, the concentration of free acetic acid in cells is kept at a low level to avoid disrupting the control of the pH of the cell contents. Acetic acid is produced and excreted by certain bacteria, notably the Acetobacter genus and Clostridium acetobutylicum. These bacteria are found universally in foodstuffs, water, and soil, and acetic acid is produced naturally as fruits and some other foods spoil. Acetic acid is also a component of the vaginal lubrication of humans and other primates, where it appears to serve as a mild antibacterial agent.

# Synonyms:
Acetate; Ethanoate; Ethanoic acid; Ethylate; Ethylic acid; Glacial acetate; Glacial acetic acid; Kyselina octova; Methanecarboxylate; Methanecarboxylic acid; Vinegar; Vinegar acid

# Chemical_IUPAC_Name:
acetic acid

# Chemical_Formula:
C2H4O2

# Chemical_Structure:
tbl_chemical:::HMDB00042_ZOOM.png:::119283150177790422

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00042_THUMB.png:::119283150004686336

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
carboxylic acid

# Taxonomy_Biofunction:
Component of Glycerophospholipid metabolism; Component of Propanoate metabolism; Component of Pyruvate metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
60.02113

# Molecular_Weight_Avg:
60.05196

# Smiles_String_isomeric:
CC(O)=O

# Smiles_String_canonical:
CC(O)=O

# KEGG_Compound_ID:
C00033

# BioCyc_ID:
ACET

# PubChem_CID:
176

# PubChem_SID:
11531946; 11538534; 554954; 10322696; 11528569; 11532670; 11538991; 11538264; 10322371; 11110076; 11531973; 11532070; 11538327; 11109921; 11110411; 10329217; 11538097; 11538202; 11532672; 550783; 10322442; 11448199; 10322636; 11110453; 566666; 11110170; 11538603; 557264; 10322927; 551159; 422198; 11532254; 555448; 554956; 554953; 3133677; 11538917; 11532383; 11538149; 554955; 554858; 11538367; 11110222; 11528326; 11539098; 11448177; 554951; 10322960; 10531526; 11109912; 11109881; 550995; 11532067; 10322507; 11538901; 577279; 550785; 10322836; 550786; 10322416; 550787; 476220; 11532794; 554952; 11539118; 11538538; 11532749; 10322364; 587335; 11538980; 10318536; 10322902; 11538438; 11538597; 550788; 11532554; 149048; 11538478; 10322373; 11532087; 11110245; 11539029; 550784; 551016; 10318673; 11532150; 11539054; 11532347; 11532288; 550782; 10318571; 10322505; 11538998; 557262; 11531941; 10322377; 11531950; 11532418; 10323025; 11538705

# OMIM_ID:
276100; 601705

# Metagene_ID:
HISTIDINEMIA: 181; HYPERPHENYLALANINEMIA DUE TO 6-PTS DEFICIENCY (PTPS): 71; MONOAMINE OXIDASE-A DEFICIENCY (MAO-A): 446; AROMATIC L-AMINO ACID DECARBOXYLASE DEFICIENCY: 354; TYROSINEMIA, TRANSIENT, OF THE NEWBORN: 318; HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY: 133; HYPERPHENYLALANIEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY: 355; BLUE DIAPER SYNDROME: 300; SEPIAPTERIN REDUCTASE DEFICIENCY: 471; KETOSIS, UNSPECIFIC [DD]: 279; DOPA-RESPONSIVE DYSTONIA: 451; PHENYLKETONURIA (PKU): 135; HAWKINSINURIA: 176; ARTEFACTS-BACTERIAL CONTAMINATION, EXCRETION OF ORGANIC ACIDS (ARTEFACTS) [DD]: 348; TYROSINEMIA III: 319; TYROSINEMIA I: 49; TYROSINEMIA II: 66; HARTNUP DISEASE. BEHAVIORAL DISTURBANCES, REVERSIBLE: 175; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
33590

# Wikipedia_ID:
Acetic acid

# METLIN_ID:
3206

# Ref_ID:
16005905; 12097436; 17060763; 16139280; 15627241; 7762816; 16029568; 7294941; 1931558; 16101231; 16086249; 16101165; 16314038

# ChEBI_ID:
15366

# CAS_Registry_Number:
64-19-7

# InChI:
InChI=1/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

# Synthesis_Reference:
A new hydroxybenzoic acid.     Emmerling, O.; Oppenheim, A.    Berl. Univ.-Laborat.,  Germany.    Berichte der Deutschen Chemischen Gesellschaft  (1876),  9  326-332.

# Melting_Point:
16.6 oC

# Melting_Point_predicted:
19.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
323.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Liquid

# LogP:
-0.17 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-0.12 [Predicted by ALOGPS]; -0.1 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00042_msds.html:::1132562192898992873

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Acetic_acid.mol:::1132723803046998461

# SDF_File_[Text]:
tbl_chemical:::HMDB00042.sdf:::119283149735732402

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00042.pdb:::119283149872337478

# PDB_ID:
1AT5

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1AT5.txt:::1132720899671846606

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_presat.png:::114684438290356775

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_presat.zip:::114684438301265950

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041201_P04_17_BA_1DP_Assigned.png:::114684438307190719

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132.jpg:::114174734655214379

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132.zip:::114174734661173899

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041201_P04_17_BA_1DC_132_Assigned.jpg:::114322759700291878

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519.jpg:::114617685182812404

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519.zip:::114617685183640505

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041201_P04_17_BA_2DHSQC_519_Assigned.PNG:::114781086158954728

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Acetic acid.gif:::1132732101781948

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00042_peaks.txt:::1156309505964703243

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Acetic acid_C.gif:::1132737665148471780

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00042_peaks.txt:::115631069760091561

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00042L.png:::11755526538265503; Medium Energy:tbl_ms:::HMDB00042M.png:::117555269955860745; High Energy:tbl_ms:::HMDB00042H.png:::117555272284322625

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000191.png:::116890828448475578

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000191.txt:::116890828468794299

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; golgi apparatus; mitochondria

# Tissue_Location:
Most Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Feces; Mucus; Saliva; Urine

# Concentration_[Normal]:
Blood	47.7 +/- 50.6	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	2.61 +/- 0.08	umol/L	Adult:>18_yrs_old	Both	Normal	17544838
Cerebrospinal_Fluid(CSF)	116.0 +/- 55.0	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	100.0 +/- 30.0	umol/L	Adult:>18_yrs_old	N/A	Normal	1931558
Cerebrospinal_Fluid(CSF)	284.0 +/- 126.0	uM	Children:1-13_yrs_old	Both	Normal	15627241
Cerebrospinal_Fluid(CSF)	219.0 +/- 109.0	uM	Adult:>18_yrs_old	Both	Normal	HMP Experimental
Saliva	169200.0 (31400.0-307000.0)	uM	Adult:>18_yrs_old	Both	Normal	12097436


# Concentration_[Abnormal]:
Urine	53.0 +/- 71.0	umol/mmol_creatinine	N/A	Both	Lung Cancer	
Cerebrospinal_Fluid(CSF)	35.3 - 211.7	uM	Adult:>18_yrs_old	N/A	Multiple sclerosis	17611627


# Associated_Disorders:
Barrett's Esophagus; Blue Diaper Syndrome; Lung Cancer; Multiple sclerosis; Neoplasia; Prostate Cancer; Spina bifida

# Pathway_Names:
Glycerophospholipid metabolism;Glycolysis;Fatty acid metabolism;Bile acid biosynthesis;Valine, leucine and isoleucine degradation;Lysine degradation;Glycerolipid metabolism;Pyruvate metabolism;Propanoate metabolism;Butanoate metabolism;Reductive carboxylate cycle (CO2 fixation);Benzoate degradation via CoA ligation;Alanine and aspartate metabolism;gamma-Hexachlorocyclohexane degradation;Valine, leucine and isoleucine degradation (Maple Syrup Urine Disease);Valine, leucine and isoleucine degradation (Propionyl-CoA Carboxylase Deficiency)

# Pathway_Images:
;Glycolysis.jpg;;;valine,leucine,and_isoleucine_degradation.jpg;Lysine_degradation.jpg;;;;;;;Aspartate_and_Alanine_metabolism.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).jpg

# KEGG_Images:
map00564;map00010;map00071;map00120;map00280;map00310;map00561;map00620;map00640;map00650;map00720;map00632;map00252;map00361;map00280;map00280

# Pathway_Graphs:
;Glycolysis_Graph.jpg;;;valine,leucine,and_isoleucine_degradation_Graph.jpg;Lysine_degradation_Graph.jpg;;;;;;;Aspartate_and_Alanine_metabolism_Graph.jpg;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease)_Graph.jpg;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease)_Graph.jpg

# Pathway_SBMLs:
;Glycolysis.xml;;;valine,leucine,and_isoleucine_degradation.xml;Lysine_degradation.xml;;;;;;;Aspartate_and_Alanine_metabolism.xml;;Valine,leucine,and_isoleucine_degradation_maple_syrup_urine_disease_(Disease).xml;Valine,leucine,and_isoleucine_degradation_propionyl-CoA_carboxylase_deficiency_(Disease).xml

# Metabolic_Enzyme_1_ID:
5771

# Metabolic_Enzyme_1_Name:
Platelet-activating factor acetylhydrolase precursor

# Metabolic_Enzyme_1_Synonyms:
PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA(2; 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase

# Metabolic_Enzyme_1_Gene_Name:
PLA2G7

# Metabolic_Enzyme_1_Protein_Sequence:
>Plateletactivating factor acetylhydrolase precursor
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN

# Metabolic_Enzyme_1_Number_of_Residues:
441

# Metabolic_Enzyme_1_Molecular_Weight:
50078

# Metabolic_Enzyme_1_Theoretical_pI:
7.61

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  1-alkyl-2-acetylglycerophosphocholine esterase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  lipid catabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  2-acetyl-1-alkylglycerophosphocholine esterase complex

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids

# Metabolic_Enzyme_1_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_1_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03403:PAF-AH_p_II

# Metabolic_Enzyme_1_Signals:
1-21

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_1_GenBank_ID_Protein:
780133

# Metabolic_Enzyme_1_SwissProt_ID:
PAFA_HUMAN (Q13093)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PLA2G7

# Metabolic_Enzyme_1_Geneatlas_id:
PLA2G7

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9040

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_1_Gene_Sequence:
>1326 bp
ATGGTGCCACCCAAATTGCATGTGCTTTTCTGCCTCTGCGGCTGCCTGGCTGTGGTTTAT
CCTTTTGACTGGCAATACATAAATCCTGTTGCCCATATGAAATCATCAGCATGGGTCAAC
AAAATACAAGTACTGATGGCTGCTGCAAGCTTTGGCCAAACTAAAATCCCCCGGGGAAAT
GGGCCTTATTCCGTTGGTTGTACAGACTTAATGTTTGATCACACTAATAAGGGCACCTTC
TTGCGTTTATATTATCCATCCCAAGATAATGATCGCCTTGACACCCTTTGGATCCCAAAT
AAAGAATATTTTTGGGGTCTTAGCAAATTTCTTGGAACACACTGGCTTATGGGCAACATT
TTGAGGTTACTCTTTGGTTCAATGACAACTCCTGCAAACTGGAATTCCCCTCTGAGGCCT
GGTGAAAAATATCCACTTGTTGTTTTTTCTCATGGTCTTGGGGCATTCAGGACACTTTAT
TCTGCTATTGGCATTGACCTGGCATCTCATGGGTTTATAGTTGCTGCTGTAGAACACAGA
GATAGATCTGCATCTGCAACTTACTATTTCAAGGACCAATCTGCTGCAGAAATAGGGGAC
AAGTCTTGGCTCTACCTTAGAACCCTGAAACAAGAGGAGGAGACACATATACGAAATGAG
CAGGTACGGCAAAGAGCAAAAGAATGTTCCCAAGCTCTCAGTCTGATTCTTGACATTGAT
CATGGAAAGCCAGTGAAGAATGCATTAGATTTAAAGTTTGATATGGAACAACTGAAGGAC
TCTATTGATAGGGAAAAAATAGCAGTAATTGGACATTCTTTTGGTGGAGCAACGGTTATT
CAGACTCTTAGTGAAGATCAGAGATTCAGATGTGGTATTGCCCTGGATGCATGGATGTTT
CCACTGGGTGATGAAGTATATTCCAGAATTCCTCAGCCCCTCTTTTTTATCAACTCTGAA
TATTTCCAATATCCTGCTAATATCATAAAAATGAAAAAATGCTACTCACCTGATAAAGAA
AGAAAGATGATTACAATCAGGGGTTCAGTCCACCAGAATTTTGCTGACTTCACTTTTGCA
ACTGGCAAAATAATTGGACACATGCTCAAATTAAAGGGAGACATAGATTCAAATGTAGCT
ATTGATCTTAGCAACAAAGCTTCATTAGCATTCTTACAAAAGCATTTAGGACTTCATAAA
GATTTTGATCAGTGGGACTGCTTGATTGAAGGAGATGATGAGAATCTTATTCCAGGGACC
AACATTAACACAACCAATCAACACATCATGTTACAGAACTCTTCAGGAATAGAGAAATAC
AATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U20157

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_1_Locus:
6p21.2-p12

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
7700381; 8624782; 7592717; 8675689; 9245731; 9412624; 9472966; 9759612; 10733466

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5527

# Metabolic_Enzyme_2_Name:
Aldehyde dehydrogenase, dimeric NADP-preferring

# Metabolic_Enzyme_2_Synonyms:
ALDH class 3; ALDHIII

# Metabolic_Enzyme_2_Gene_Name:
ALDH3A1

# Metabolic_Enzyme_2_Protein_Sequence:
>Aldehyde dehydrogenase, dimeric NADPpreferring
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

# Metabolic_Enzyme_2_Number_of_Residues:
453

# Metabolic_Enzyme_2_Molecular_Weight:
50380

# Metabolic_Enzyme_2_Theoretical_pI:
6.52

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_2_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

# Metabolic_Enzyme_2_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_2_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
178402

# Metabolic_Enzyme_2_SwissProt_ID:
AL3A1_HUMAN (P30838)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ALDH3A1

# Metabolic_Enzyme_2_Geneatlas_id:
ALDH3A1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:405

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_2_Gene_Sequence:
>1362 bp
ATGAGCAAGATCAGCGAGGCCGTGAAGCGCGCCCGCGCCGCCTTCAGCTCGGGCAGGACC
CGTCCGCTGCAGTTCCGATTCCAGCAGCTGGAGGCGCTGCAGCGCCTGATCCAGGAGCAG
GAGCAGGAGCTGGTGGGCGCGCTGGCCGCAGACCTGCACAAGAATGAATGGAACGCCTAC
TATGAGGAGGTGGTGTACGTCCTAGAGGAGATCGAGTACATGATCCAGAAGCTCCCTGAG
TGGGCCGCGGATGAGCCCGTGGAGAAGACGCCCCAGACTCAGCAGGACGAGCTCTACATC
CACTCGGAGCCACTGGGCGTGGTCCTCGTCATTGGCACCTGGAACTACCCCTTCAACCTC
ACCATCCAGCCCATGGTGGGCGCCATCGCTGCAGGGAACGCAGTGGTCCTCAAGCCCTCG
GAGCTGAGTGAGAACATGGCGAGCCTGCTGGCTACCATCATCCCCCAGTACCTGGACAAG
GATCTGTACCCAGTAATCAATGGGGGTGTCCCTGAGACCACGGAGCTGCTCAAGGAGAGG
TTCGACCATATCCTGTACACGGGCAGCACGGGGGTGGGGAAGATCATCATGACGGCTGCT
GCCAAGCACCTGACCCCTGTCACGCTGGAGCTGGGAGGGAAGAGTCCCTGCTACGTGGAC
AAGAACTGTGACCTGGACGTGGCCTGCCGACGCATCGCCTGGGGGAAATTCATGAACAGT
GGCCAGACCTGCGTGGCCCCAGACTACATCCTCTGTGACCCCTCGATCCAGAACCAAATT
GTGGAGAAGCTCAAGAAGTCACTGAAAGAGTTCTACGGGGAAGATGCTAAGAAATCCCGG
GACTATGGAAGAATCATTAGTGCCCGGCACTTCCAGAGGGTGATGGGCCTGATTGAGGGC
CAGAAGGTGGCTTATGGGGGCACCGGGGATGCCGCCACTCGCTACATAGCCCCCACCATC
CTCACGGACGTGGACCCCCAGTCCCCGGTGATGCAAGAGGAGATCTTCGGGCCTGTGCTG
CCCATCGTGTGCGTGCGCAGCCTGGAGGAGGCCATCCAGTTCATCAACCAGCGTGAGAAG
CCCCTGGCCCTCTACATGTTCTCCAGCAACGACAAGGTGATTAAGAAGATGATTGCAGAG
ACATCCAGTGGTGGGGTGGCGGCCAACGATGTCATCGTCCACATCACCTTGCACTCTCTG
CCCTTCGGGGGCGTGGGGAACAGCGGCATGGGATCCTACCATGGCAAGAAGAGCTTCGAG
ACTTTCTCTCACCGCCGCTCTTGCCTGGTGAGGCCTCTGATGAATGATGAAGGCCTGAAG
GTCAGATACCCCCCGAGCCCGGCCAAGATGACCCAGCACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M74542

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_2_Locus:
17p11.2

# Metabolic_Enzyme_2_SNPs:
rs887241; rs2228100; rs3744692; rs2072330; rs4646787; rs1042183; rs917520; rs4646789; rs4646788; rs3786036; rs887240; rs2072329; rs4646790; rs3744693; rs9895030; rs3826507; rs3744695; rs3744694; rs2072328; rs1006556; rs4319825; rs1042172; rs11554977; rs11554978; rs11554975; rs11554974; rs34474118; rs3786037; rs35473971; rs4646792; rs35116940; rs4646791; rs35853488; rs887239; rs28531080; rs7216299; rs35009373; rs3786035; rs11385990; rs35308039; rs35128135; rs35885485; rs28552545; rs34438543; rs1006553; rs11650088; rs11651480; rs11870332; rs12948881; rs12949049; rs12951039; rs16960382; rs16960386; rs17793620; rs1989379; rs2016823; rs2052052; rs2072327; rs2108967; rs3760485; rs3760486; rs3760487; rs4646783; rs4646784; rs4646785; rs4646786; rs4924793; rs4925046; rs7214841; rs7221211; rs7225305; rs8075157; rs9898715; rs9900430

# Metabolic_Enzyme_2_General_References:
1737758; 8493892; 2037078; 9250352

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5528

# Metabolic_Enzyme_3_Name:
Alpha-aminoadipic semialdehyde dehydrogenase

# Metabolic_Enzyme_3_Synonyms:
Alpha-AASA dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenease; P6c dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1

# Metabolic_Enzyme_3_Gene_Name:
ALDH7A1

# Metabolic_Enzyme_3_Protein_Sequence:
>Alphaaminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADY
EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVN
LLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWN
NEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ

# Metabolic_Enzyme_3_Number_of_Residues:
511

# Metabolic_Enzyme_3_Molecular_Weight:
55367

# Metabolic_Enzyme_3_Theoretical_pI:
6.86

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H

# Metabolic_Enzyme_3_Pathway:
map00300  Lysine biosynthesis;
 map00310  Lysine degradation

# Metabolic_Enzyme_3_Reaction:
L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.2.1.31

# Metabolic_Enzyme_3_GenBank_ID_Protein:
797410

# Metabolic_Enzyme_3_SwissProt_ID:
AL7A1_HUMAN (P49419)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ALDH7A1

# Metabolic_Enzyme_3_Geneatlas_id:
ALDH7A1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:877

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1536 bp
ATGTCCACTCTCCTCATCAATCAGCCCCAGTATGCGTGGCTGAAAGAGCTGGGGCTCCGC
GAGGAAAACGAGGGCGTGTATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATTACGACC
TATTGCCCCGCTAACAACGAGCCAATAGCAAGAGTCCGACAGGCCAGTGTGGCAGACTAT
GAAGAAACTGTAAAGAAAGCAAGAGAAGCATGGAAAATCTGGGCAGATATTCCTGCTCCA
AAACGAGGAGAAATAGTAAGACAGATTGGCGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAAATCTTAGTGGAAGGTGTGGGTGAAGTTCAG
GAGTATGTGGATATCTGTGACTATGCTGTTGGTTTATCAAGGATGATTGGAGGACCTATC
TTGCCTTCTGAAAGATCTGGCCATGCACTGATTGAGCAGTGGAATCCCGTAGGCCTGGTT
GGAATCATCACGGCATTCAATTTCCCTGTGGCAGTGTATGGTTGGAACAACGCCATCGCC
ATGATCTGTGGAAATGTCTGCCTCTGGAAAGGAGCTCCAACCACTTCCCTCATTAGTGTG
GCTGTCACAAAGATAATAGCCAAGGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATTGGCACAGCAATGGCCAAAGATGAACGAGTGAAC
CTGCTGTCCTTCACTGGGAGCACTCAGGTGGGAAAACAGGTGGGCCTGATGGTGCAGGAG
AGGTTTGGGAGAAGTCTGTTGGAACTTGGAGGAAACAATGCCATTATTGCCTTTGAAGAT
GCAGACCTCAGCTTAGTTGTTCCATCAGCTCTCTTCGCTGCTGTGGGAACAGCTGGCCAG
AGGTGTACCACTGCGAGGCGACTGTTTATACATGAAAGCATCCATGATGAGGTTGTAAAC
AGACTTAAAAAGGCCTATGCACAGATCCGAGTTGGGAACCCATGGGACCCTAATGTTCTC
TATGGGCCACTCCACACCAAGCAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACAGTGGTCTATGGGGGCAAGGTTATGGATCGCCCTGGAAATTAT
GTAGAACCGACAATTGTGACAGGTCTTGGCCACGATGCGTCCATTGCACACACAGAGACT
TTCGCTCCGATTCTCTATGTCTTTAAATTCAAGAATGAAGAAGAGGTCTTTGCATGGAAT
AATGAAGTAAAACAGGGACTTTCAAGTAGCATCTTTACCAAAGATCTGGGCAGAATCTTT
CGCTGGCTTGGACCTAAAGGATCAGACTGTGGCATTGTAAATGTCAACATTCCAACAAGT
GGGGCTGAGATTGGAGGTGCCTTTGGAGGAGAAAAGCACACTGGTGGTGGCAGGGAGTCT
GGCAGTGATGCCTGGAAACAGTACATGAGAAGGTCTACTTGTACTATCAACTACAGTAAA
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
S74728

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_3_Locus:
5q31

# Metabolic_Enzyme_3_SNPs:
rs12514417; rs2306618; rs2775; rs1038381; rs6595719; rs4835912; rs1038378; rs1038380; rs2306617; rs4379190; rs4836276; rs11241901; rs4240406; rs12513847; rs7709115; rs4836272; rs7713264; rs6870785; rs11241902; rs7714044; rs1038379; rs10050642; rs7723008; rs4836277; rs3734175; rs6898430; rs17154671; rs4626334; rs13182402; rs17154679; rs4835914; rs12653605; rs2306619; rs7719675; rs10478743; rs7700981; rs2035472; rs11241903; rs6861395; rs7724875; rs2291295; rs10519915; rs7719712; rs6898559; rs4626335; rs17154676; rs11952752; rs13179664; rs4835913; rs11742214; rs3734174; rs11742381; rs7736031; rs7737529; rs10478744; rs4836275; rs17154666; rs34241005; rs10043987; rs7718426; rs2013986; rs10067785; rs7719091; rs17165056; rs13188450; rs900645; rs7708281; rs7703958; rs7723494; rs10050872; rs7702811; rs13171814; rs6897789; rs13177576; rs7704283; rs4526102; rs11741551; rs10038571; rs4836273; rs3736174; rs3736171; rs1483780; rs900641; rs744722; rs900640; rs7718710; rs1060856; rs744720; rs17165061; rs744721; rs1807; rs6865317; rs6884473; rs7447092; rs3189320; rs1049217; rs1049211; rs11542969; rs1049214; rs11269202; rs6898845; rs35027610; rs35284915; rs34275373; rs35570062; rs34674137; rs28429591; rs7730016; rs4612066; rs36058537; rs2408702; rs11406545; rs1142071; rs13356526; rs35492150; rs34697893; rs10539406; rs34825424; rs7703752; rs12187161; rs34949719; rs36125577; rs36077292; rs7719949; rs35736560; rs34201518; rs33926729; rs34250591; rs13185811; rs34323751; rs34907915; rs28865092; rs35559498; rs35109136; rs10630162; rs4836274; rs34972014; rs13173864; rs7709981; rs6870070; rs2408703; rs35118533; rs10532390; rs34517958; rs34069611; rs10629966; rs7706009; rs34496788; rs34935903; rs35115612; rs13174679; rs10609859; rs34995966; rs34074703; rs36120385; rs34424711; rs34537297; rs7737783; rs35457522; rs35367836; rs36017518; rs17597559; rs7730933; rs33954485; rs35196030; rs35930104; rs34575294; rs10666972; rs10676689; rs35010266; rs34035179; rs28629815; rs7704352; rs35797169; rs10044223; rs35622239; rs35960414; rs34959052; rs35342756; rs13154789; rs4836278; rs35617751; rs34731336; rs12656014; rs34305021; rs34684581; rs5871220; rs11951146; rs35290920; rs13166319; rs2408633; rs11290126; rs34862437; rs35992646; rs35110442; rs10609860; rs11742868; rs6896807; rs17531712; rs34770295; rs3080835; rs11387172; rs7737256; rs34601459; rs9765047; rs1060857; rs3736172; rs11458774; rs1138001; rs7447380; rs5871218; rs1138005; rs34410568; rs3736173; rs35569843; rs744723; rs5871219; rs34450389; rs34135005; rs3830274; rs11750167; rs1384880; rs17154635; rs2035471; rs2128931; rs2306620; rs2306621; rs2306622; rs2408700; rs28365789; rs3734173; rs4240405; rs4597966; rs4835911; rs4836271; rs6882015; rs730870; rs7715516; rs7726892

# Metabolic_Enzyme_3_General_References:
8088832; 9417906

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5785

# Metabolic_Enzyme_4_Name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic

# Metabolic_Enzyme_4_Synonyms:
Serine-dependent phospholipase A2; HSD-PLA2

# Metabolic_Enzyme_4_Gene_Name:
PAFAH2

# Metabolic_Enzyme_4_Protein_Sequence:
>Plateletactivating factor acetylhydrolase 2, cytoplasmic
MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAEETMEQPLWIPRYEYCT
GLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSGYPLIIFSHGLGAFRTLYSAF
CMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNESLQEEWIPFRRVEEGEKEFHV
RNPQVHQRVSECLRVLKILQEVTAGQTVFNILPGGLDLMTLKGNIDMSRVAVMGHSFGGA
TAILALAKETQFRCAVALDAWMFPLERDFYPKARGPVFFINTEKFQTMESVNLMKKICAQ
HEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFSTETRGSLDPYEGQEVMVRAMLAFLQKH
LDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL

# Metabolic_Enzyme_4_Number_of_Residues:
392

# Metabolic_Enzyme_4_Molecular_Weight:
44036

# Metabolic_Enzyme_4_Theoretical_pI:
6.89

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  1-alkyl-2-acetylglycerophosphocholine esterase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  lipid catabolism
 ||
>>>
Component:  protein complex
Component:  unlocalized protein complex
Component:  2-acetyl-1-alkylglycerophosphocholine esterase complex

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme

# Metabolic_Enzyme_4_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_4_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03403:PAF-AH_p_II

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_4_GenBank_ID_Protein:
1765864

# Metabolic_Enzyme_4_SwissProt_ID:
PAFA2_HUMAN (Q99487)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
PAFAH2

# Metabolic_Enzyme_4_Geneatlas_id:
PAFAH2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:8579

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>1179 bp
ATGGGGGTCAACCAGTCTGTGGGCTTTCCACCTGTCACAGGACCCCACCTCGTAGGCTGT
GGGGATGTGATGGAGGGTCAGAATCTCCAGGGGAGCTTCTTTCGACTCTTCTACCCCTGC
CAAAAGGCAGAGGAGACCATGGAGCAGCCCCTGTGGATTCCCCGCTATGAGTACTGCACT
GGCCTGGCCGAGTACCTGCAGTTTAATAAGCGCTGCGGGGGCTTGCTGTTCAACCTGGCG
GTGGGATCTTGTCGCCTGCCTGTTAGCTGGAATGGCCCCTTTAAGACAAAGGACTCTGGA
TACCCCTTGATCATCTTCTCCCATGGCCTAGGAGCCTTCAGGACTTTGTATTCAGCCTTC
TGCATGGAGCTGGCCTCACGTGGCTTTGTGGTTGCTGTGCCAGAGCACAGGGACCGGTCA
GCGGCAACCACCTATTTCTGCAAGCAGGCCCCAGAAGAGAACCAGCCCACCAATGAATCG
CTGCAGGAGGAATGGATCCCTTTCCGTCGAGTTGAGGAAGGGGAGAAGGAATTTCATGTT
CGGAATCCCCAGGTGCATCAGCGGGTAAGCGAGTGTTTACGGGTGTTGAAGATCCTGCAA
GAGGTCACTGCTGGGCAGACTGTCTTCAACATCTTGCCTGGTGGCTTGGATCTGATGACT
TTGAAGGGCAACATTGACATGAGCCGTGTGGCTGTGATGGGACATTCATTTGGAGGGGCC
ACAGCTATTCTGGCTTTGGCCAAGGAGACCCAATTTCGGTGTGCGGTGGCTCTGGATGCT
TGGATGTTTCCTCTGGAACGTGACTTTTACCCCAAGGCCCGAGGACCTGTGTTCTTTATC
AATACTGAGAAATTCCAGACAATGGAGAGTGTCAATTTGATGAAGAAGATATGTGCCCAG
CATGAACAGTCTAGGATCATAACCGTTCTTGGTTCTGTTCATCGGAGTCAAACTGACTTT
GCTTTTGTGACTGGCAACTTGATTGGTAAATTCTTCTCCACTGAAACCCGTGGGAGCCTG
GACCCCTATGAAGGGCAGGAGGTTATGGTACGGGCCATGTTGGCCTTCCTGCAGAAGCAC
CTCGACCTGAAAGAAGACTATAATCAATGGAACAACCTTATTGAAGGCATTGGACCGTCG
CTCACCCCAGGGGCCCCCCACCATCTGTCCAGCCTGTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D87845

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p34.3

# Metabolic_Enzyme_4_SNPs:
rs34555067; rs1932067; rs12408803; rs3008423; rs11247841; rs2992056; rs6598938; rs11247840; rs6657145; rs2012311; rs933078; rs3738455; rs12042915; rs9438606; rs17163462; rs2992055; rs7355094; rs17163460; rs10794520; rs17163464; rs10794521; rs298442; rs2275102; rs1469511; rs6662751; rs1257156; rs3767929; rs6680265; rs3738458; rs1257155; rs298441; rs4659400; rs1257153; rs10902716; rs1469510; rs298443; rs7553386; rs11247834; rs1429936; rs11581726; rs2275101; rs7543346; rs1469512; rs6683366; rs298449; rs7536067; rs3767928; rs10751732; rs11247839; rs10902715; rs10794519; rs1889605; rs4507998; rs2257255; rs2914970; rs11247838; rs11580136; rs10794518; rs12136909; rs298448; rs1257152; rs12080982; rs298444; rs11247837; rs11582253; rs12565672; rs12030759; rs2245979; rs10902713; rs6696592; rs11247836; rs6598937; rs10902712; rs12240057; rs12138372; rs2039542; rs298445; rs2782814; rs298458; rs2992071; rs34317686; rs12410711; rs35020920; rs35335420; rs11590732; rs34512807; rs34273468; rs35710365; rs4659361; rs11327055; rs3008239; rs35480896; rs12041217; rs12757628; rs35497051; rs34534304; rs35383525; rs6678309; rs34108084; rs34937286; rs11289287; rs35777678; rs11325353; rs2914967; rs2992062; rs12078456; rs35304992; rs2992061; rs3738456; rs298446; rs12035930; rs12079021; rs12128156; rs298447; rs34894360; rs28699515; rs7529111; rs4659399; rs1272735; rs35755086; rs35753945; rs34522205; rs1269087; rs12092409; rs12239959; rs298450; rs4350193; rs12239914; rs34853555; rs35780536; rs34681521; rs5773141; rs10902714; rs9438538; rs3008422; rs34825646; rs34187194; rs35865072; rs35581219; rs35627679; rs12136914; rs35319124; rs2782821; rs182439; rs1257154; rs3008410; rs2914968; rs28757614; rs11247835; rs34882050; rs2992060; rs12406618; rs35441797; rs3008421; rs28433155; rs11577113; rs34878410; rs35739814; rs41334746; rs35864830; rs34043562; rs10751731; rs11247842; rs12074251; rs12744951; rs2914971; rs298454; rs298456; rs298457; rs2992064; rs3008236; rs3008240; rs3008241; rs3008412; rs35874022; rs4659401; rs5014395

# Metabolic_Enzyme_4_General_References:
8955149; 9494101; 9218411

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5529

# Metabolic_Enzyme_5_Name:
Aldehyde dehydrogenase 1A3

# Metabolic_Enzyme_5_Synonyms:
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3

# Metabolic_Enzyme_5_Gene_Name:
ALDH1A3

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldehyde dehydrogenase 1A3
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP

# Metabolic_Enzyme_5_Number_of_Residues:
512

# Metabolic_Enzyme_5_Molecular_Weight:
56109

# Metabolic_Enzyme_5_Theoretical_pI:
7.29

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_5_Specific_Function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

# Metabolic_Enzyme_5_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_5_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
544482

# Metabolic_Enzyme_5_SwissProt_ID:
AL1A3_HUMAN (P47895)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ALDH1A3

# Metabolic_Enzyme_5_Geneatlas_id:
ALDH1A3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:409

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1539 bp
ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACGGGAAGCCGCCGGCCCTG
CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAGATATTTATCAACAATGAATGG
CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA
TGTGAAGTGGAAGAAGGAGATAAGCCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT
GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG
CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCCGCCCTGGAGACGATG
GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC
CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAGATGAC
AACGTCGTATGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCATGG
AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC
ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC
AAAGAGGCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG
GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG
GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG
CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACTTGGACTTGGCAGTGGAG
TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG
TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA
CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAGATTGATCAAAAG
CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA
TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA
GTCACAGACAACATGCGGATTGCCAAAGAGGAGATTTTCGGGCCAGTGCAACCAATACTG
AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA
GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT
GGAACGGTCTGGATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT
AAAATGTCAGGAAATGGCAGAGAACTAGGTGAATACGCTTTGGCCGAATACACAGAAGTG
AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U07919

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_5_Locus:
15q26.3

# Metabolic_Enzyme_5_SNPs:
rs3803430; rs2229183; rs1130738; rs14226; rs3803424; rs7045; rs3803426; rs7182089; rs4646690; rs7161860; rs4246328; rs4646688; rs4646668; rs4646670; rs3803428; rs4646671; rs6598396; rs4646675; rs9944290; rs7181897; rs4646684; rs4246323; rs4246327; rs4246329; rs4646674; rs8039374; rs4646678; rs4646653; rs4646655; rs7182884; rs3809521; rs11854028; rs3825926; rs3803433; rs6598397; rs4646662; rs4646685; rs4646651; rs4646672; rs3922685; rs4646654; rs3902902; rs4646683; rs7176046; rs3803432; rs4246324; rs4646661; rs8030776; rs12903828; rs4646687; rs4646680; rs3825925; rs7178221; rs3803427; rs7170197; rs4246325; rs8023972; rs4646681; rs7167278; rs4246326; rs1886; rs4646649; rs12908902; rs7171776; rs3803429; rs12914598; rs4646669; rs4646650; rs3803434; rs4646660; rs4646682; rs3809524; rs3809523; rs3809526; rs7179268; rs1130737; rs3803431; rs1130768; rs34302490; rs28760343; rs35300460; rs1802602; rs1802604; rs4288979; rs3803425; rs1802603; rs4646663; rs28691047; rs28731371; rs34655770; rs35165034; rs28509297; rs10400871; rs35129664; rs12905372; rs28405557; rs34486175; rs28546254; rs35055541; rs4646686; rs28441320; rs28410143; rs4646676; rs4646648; rs8029933; rs12910188; rs34182689; rs28504296; rs28449981; rs28507582; rs3825927; rs35310246; rs12910025; rs28384196; rs4343265; rs12910662; rs8028283; rs28475530; rs4392045; rs28369514; rs28377287; rs8035722; rs28480133; rs28707102; rs28583888; rs4646666; rs7173413; rs28472416; rs28673034; rs28668881; rs28711429; rs34837038; rs4646659; rs28452487; rs28712665; rs12910029; rs12902704; rs4646673; rs28689536; rs28431101; rs34431941; rs7178645; rs28454526; rs7170202; rs1889; rs4646647; rs4375646; rs11348272; rs4646656; rs28408085; rs28699556; rs28615197; rs28539744; rs28557216; rs28631565; rs34302839; rs3923499; rs4646664; rs35740226; rs28385499; rs3922686; rs28474807; rs28490217; rs12909825; rs10593974; rs28679806; rs28610999; rs7178553; rs35519561; rs35831758; rs35526807; rs4646658; rs28538652; rs28685242; rs10400842; rs4646667; rs35948146; rs4646677; rs7165217; rs10400872; rs28750207; rs3825924; rs7171453; rs34906846; rs4646665; rs9920154; rs36081993; rs11435500; rs28464660; rs4646679; rs12595234; rs4646689; rs3809522; rs35950557; rs3809527; rs7172149; rs7178931; rs8034153; rs7183889; rs3809525; rs4646646; rs11630601; rs11630691; rs11632820; rs11637204; rs11854709; rs12148466; rs12148493; rs12440023; rs12593839; rs12901792; rs12907776; rs12908105; rs12909230; rs12909791; rs28507591; rs3803435; rs4346184; rs4646694; rs7163108; rs7164136; rs7181644; rs8034686; rs8035036

# Metabolic_Enzyme_5_General_References:
7698756

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5266

# Metabolic_Enzyme_6_Name:
Acetyl-coenzyme A synthetase, cytoplasmic

# Metabolic_Enzyme_6_Synonyms:
Acetate--CoA ligase; Acyl-activating enzyme; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2

# Metabolic_Enzyme_6_Gene_Name:
ACSS2

# Metabolic_Enzyme_6_Protein_Sequence:
>Acetylcoenzyme A synthetase, cytoplasmic
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

# Metabolic_Enzyme_6_Number_of_Residues:
701

# Metabolic_Enzyme_6_Molecular_Weight:
78580

# Metabolic_Enzyme_6_Theoretical_pI:
6.43

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation

# Metabolic_Enzyme_6_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_6_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
8439651

# Metabolic_Enzyme_6_SwissProt_ID:
ACSA_HUMAN (Q9NR19)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
ACSS2

# Metabolic_Enzyme_6_Geneatlas_id:
ACSS2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:15814

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>2106 bp
ATGGGGCTTCCTGAGGAGCGGGTCCGGAGCGGCAGCGGGAGCCGGGGCCAGGAGGAAGCT
GGAGCCGGAGGCCGGGCGCGGAGTTGGTCTCCGCCGCCCGAGGTCAGCCGCTCCGCGCAC
GTCCCCTCGCTGCAGCGCTACCGCGAGCTGCACCGGCGCTCCGTGGAGGAGCCGCGGGAA
TTCTGGGGAGACATTGCCAAGGAATTTTACTGGAAGACTCCATGCCCTGGCCCATTCCTT
CGGTACAACTTTGATGTGACTAAAGGGAAAATCTTCATTGAGTGGATGAAAGGAGCAACT
ACCAACATCTGCTACAATGTACTGGATCGAAATGTCCATGAGAAAAAGCTTGGAGATAAA
GTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACTCAGATCACATACCATCAG
CTTCTGGTCCAAGTGTGTCAGTTCAGCAATGTTCTCCGAAAACAGGGCATTCAGAAGGGG
GACCGAGTGGCCATCTACATGCCTATGATCCCAGAGCTTGTGGTGGCCATGCTGGCATGT
GCCCGCATTGGGGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTTCAGAGTCTCTATGT
GAACGGATCTTGGATTCCAGCTGCAGTCTTCTCATCACTACAGATGCCTTCTACAGGGGG
GAAAAGCTTGTGAACCTGAAGGAGCTGGCTGACGAGGCCCTGCAGAAGTGTCAGGAGAAG
GGTTTCCCAGTAAGATGCTGCATTGTGGTCAAGCACCTGGGGCGGGCAGAGCTCGGCATG
GGTGACTCCACCAGCCAGTCCCCCCCAATTAAGAGGTCATGCCCAGATGTGCAGATCTCA
TGGAACCAAGGGATTGACTTGTGGTGGCATGAGCTCATGCAAGAGGCAGGGGATGAGTGT
GAGCCCGAGTGGTGTGATGCCGAGGACCCACTCTTCATCCTGTACACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTTCACACAGTTGGGGGCTACATGCTCTATGTAGCCACAACC
TTCAAGTATGTGTTTGACTTCCATGCAGAGGATGTGTTCTGGTGCACGGCAGACATTGGT
TGGATCACTGGTCATTCCTACGTCACCTATGGGCCACTGGCCAATGGTGCCACCAGTGTT
TTGTTTGAGGGGATTCCCACATATCCGGACGTGAACCGCCTGTGGAGCATTGTGGACAAA
TACAAGGTGACCAAGTTCTACACAGCACCCACAGCCATCCGTCTGCTCATGAAGTTTGGA
GATGAGCCTGTCACCAAGCATAGCCGGGCATCCTTGCAGGTGTTAGGCACAGTGGGTGAA
CCCATCAACCCTGAGGCCTGGCTATGGTACCACCGGGTGGTAGGTGCCCAGCGCTGCCCC
ATCGTGGACACCTTCTGGCAAACAGAGACAGGTGGCCACATGTTGACTCCCCTTCCTGGT
GCCACACCCATGAAACCCGGTTCTGCTACTTTCCCATTCTTTGGTGTAGCTCCTGCAATC
CTGAATGAGTCCGGGGAAGAGTTGGAAGGTGAAGCTGAAGGTTATCTGGTGTTCAAGCAG
CCCTGGCCAGGGATCATGCGCACAGTCTATGGGAACCACGAACGCTTTGAGACAACCTAC
TTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGCTGCCAGCGGGACCAGGATGGC
TATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGT
ACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTG
GGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGC
CACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGG
AAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATG
TCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATC
CAGTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF263614

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_6_Locus:
20q11.22

# Metabolic_Enzyme_6_SNPs:
rs4911163; rs10485507; rs6120750; rs1013677; rs6088635; rs6579198; rs6058135; rs6087642; rs6087641; rs6088638; rs6088636; rs7509557; rs6088650; rs6087644; rs6120758; rs4911164; rs6060112; rs8119110; rs6120763; rs6087649; rs6058137; rs3746450; rs4911447; rs6088640; rs1060615; rs6119542; rs926734; rs8116657; rs4911451; rs6119543; rs6120757; rs4911449; rs6088646; rs2295097; rs6087643; rs2223881; rs6088642; rs8117380; rs2273683; rs8123210; rs11905770; rs2064454; rs2076667; rs12717838; rs3818273; rs3787215; rs2207147; rs6120754; rs4911450; rs7266550; rs4911448; rs2378294; rs8125240; rs2378291; rs17092174; rs2378292; rs6058142; rs6120756; rs3787214; rs6120753; rs17092163; rs17092169; rs6060107; rs6060113; rs2378293; rs8117491; rs6120759; rs6088647; rs17850882; rs6088649; rs4349415; rs13043365; rs2295096; rs34527271; rs13043347; rs35779501; rs3053923; rs35596631; rs6088637; rs8115733; rs7509556; rs2024634; rs11476807; rs6060105; rs11472785; rs2024633; rs11467604; rs6120749; rs35991119; rs1062891; rs2024632; rs11167247; rs17400522; rs11699241; rs11472114; rs36077883; rs13042631; rs34362920; rs35104294; rs6119540; rs11478163; rs6088651; rs2295095; rs9547; rs11299664; rs6142261; rs35620674; rs35540450; rs6060111; rs3054612; rs6120752; rs11479533; rs34171408; rs11425079; rs6142260; rs34872018; rs11697404; rs11481649; rs7268774; rs34951413; rs33930398; rs6087647; rs34277751; rs6119544; rs35456894; rs6120764; rs6087646; rs11476381; rs11479477; rs28878236; rs6142263; rs6058143; rs5841186; rs28802941; rs8119835; rs6058136; rs3054610; rs6120755; rs28434523; rs35234476; rs8184664; rs11474295; rs35208311; rs34525778; rs36108141; rs34213461; rs6142258; rs2378290; rs6088639; rs6060110; rs6088643; rs36102262; rs11699164; rs35470839; rs35962008; rs6142259; rs11421679; rs10542624; rs8183627; rs6142255; rs34682859; rs35504652; rs11474981; rs6060106; rs6060115; rs35655449; rs34939273; rs11482260; rs4588263; rs34590082; rs13038710; rs6120760; rs6058138; rs6058139; rs35212956; rs35067244; rs6088645; rs6060108; rs11483997; rs11477769; rs4600736; rs7260994; rs6142256; rs11479348; rs6120761; rs6141520; rs6087645; rs13044142; rs34680118; rs11481648; rs35773172; rs13339938; rs36019966; rs35404681; rs6142257; rs13038395; rs13040750; rs5841185; rs34109099; rs35829893; rs34032248; rs13041047; rs11476265; rs41287074; rs11469541; rs6088641; rs35102137; rs6142254; rs34578238; rs10554596; rs34807244; rs6119541; rs28694099; rs34675937; rs34401220; rs6120751; rs35359973; rs6060109; rs6060104; rs17309872; rs2064453; rs2236270; rs2236271; rs6060103; rs6087651; rs6088628; rs6088629; rs6088631; rs6088652; rs725521; rs7263157; rs7264920; rs7265109; rs7265992; rs7269682

# Metabolic_Enzyme_6_General_References:
10843999; 11780052

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5811

# Metabolic_Enzyme_7_Name:
Aldehyde dehydrogenase 3B1

# Metabolic_Enzyme_7_Synonyms:
Aldehyde dehydrogenase 7

# Metabolic_Enzyme_7_Gene_Name:
ALDH3B1

# Metabolic_Enzyme_7_Protein_Sequence:
>Aldehyde dehydrogenase 3B1
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

# Metabolic_Enzyme_7_Number_of_Residues:
468

# Metabolic_Enzyme_7_Molecular_Weight:
51840

# Metabolic_Enzyme_7_Theoretical_pI:
7.67

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_7_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_7_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_7_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
601780

# Metabolic_Enzyme_7_SwissProt_ID:
AL3B1_HUMAN (P43353)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
ALDH3B1

# Metabolic_Enzyme_7_Geneatlas_id:
ALDH3B1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:410

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>1407 bp
ATGGACCCCCTTGGGGACACGCTGCGGCGACTGCGGGAGGCCTTCCACGCGGGGCGCACG
CGGCCAGCTGAGTTCCGGGCTGCGCAGCTCCAAGGCCTGGGCCGCTTCCTGCAAGAAAAC
AAGCAGCTTCTGCACGACGCACTGGCCCAGGACCTGCACAAGTCAGCCTTCGAGTCGGAG
GTGTCTGAGGTTGCCATCAGCCAGGGCGAGGTCACCCTGGCCCTCAGGAACCTCCGGGCC
TGGATGAAGGACGAGCGTGTGCCCAAGAACCTGGCCACGCAGCTGGACTCCGCCTTCATC
CGGAAGGAGCCCTTTGGCCTGGTCCTCATCATTGCGCCCTGGAACTATCCGCTGAACCTG
ACGCTGGTGCCCCTCGTGGGAGCCCTCGCTGCAGGGAACTGTGTGGTGCTGAAGCCATCG
GAGATTAGCAAGAACGTCGAGAAGATCCTGGCCGAGGTGCTGCCCCAATACGTGGACCAG
AGCTGCTTTGCTGTGGTGCTGGGCGGGCCCCAGGAGACGGGGCAGCTGCTAGAGCACAGG
TTCGACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTTATGACTGCTGCC
GCCAAGCACCTGACACCTGTCACCCTGGAGCTGGGGGGCAAGAACCCTTGCTACGTGGAC
GACAACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCCGCTACTTCAACGCC
GGCCAGACCTGCGTGGCCCCCGACTACGTCCTATGCAGCCCTGAGATGCAGGAGAGGCTG
CTGCCTGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCA
AACCTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGC
GGCCGTGTGGCCATTGGGGGCCAGAGCGATGAGAGCGATCGCTACATCGCCCCCACGGTG
CTGGTGGATGTGCAGGAGATGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTG
CCCATCGTGAACGTGCAGAGCTTGGACGAGGCCATCGAGTTCATCAACCGGCGGGAGAAG
CCCCTGGCCCTGTACGCCTTCTCCAACAGCAGCCAGGTGGTCAAGCGGGTGCTGACCCAG
ACCAGCAGCGGGGGCTTCTGTGGGAACGACGGCTTCATGCACATGACCCTGGCCAGCCTG
CCTTTTGGAGGAGTGGGTGCCAGTGGGATGGGCCGGTACCATGGCAAGTTCTCCTTCGAC
ACCTTCTCCCACCATCGCGCCTGCCTCCTGCGCAGCCCGGGGATGGAGAAGCTCAACGCC
CTCCGCTACCCGCCGCAATCGCCGCGCCGCCTGAGGATGCTGCTGGTGGCCATGGAGGCC
CAAGGCTGCAGCTGCACACTGCTCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
U10868

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11q13

# Metabolic_Enzyme_7_SNPs:
rs572574; rs3764821; rs172620; rs3794181; rs3751081; rs12281209; rs1703440; rs3764818; rs556601; rs2286170; rs1003777; rs308293; rs2286169; rs4646809; rs3764819; rs886702; rs2286163; rs2286164; rs3794177; rs2286165; rs105147; rs2286168; rs2286166; rs308342; rs7125916; rs2286171; rs3794176; rs581105; rs12574760; rs3751082; rs308341; rs34280013; rs475325; rs3764817; rs3751084; rs4244839; rs4646812; rs598156; rs3764816; rs1636207; rs886701; rs11228121; rs308336; rs2010404; rs308335; rs557098; rs308334; rs308338; rs308337; rs3763941; rs737265; rs308333; rs35738719; rs12794336; rs34580830; rs11607185; rs1636208; rs1793238; rs1636209; rs11605214; rs7108283; rs3815220; rs12286110; rs34494820; rs35406834; rs2286167; rs12789057; rs33945294; rs7116695; rs35785905; rs11436139; rs28584816; rs12799330; rs4646808; rs5792429; rs4646813; rs12284146; rs12806003; rs4646811; rs34109111; rs35256233; rs34526809; rs12277180; rs4646810; rs177812; rs34271562; rs8181582; rs11433668; rs7925460; rs34588975; rs34721102; rs7116941; rs3794179; rs12273237; rs34130972; rs5792428; rs7113328; rs34928150; rs7117605; rs35400021; rs11826595; rs1051806; rs1076558; rs10896288; rs1122731; rs11228120; rs11228122; rs11823975; rs11824781; rs11825872; rs12418774; rs12421254; rs12803743; rs1703438; rs1804688; rs191064; rs191065; rs2075626; rs2286172; rs28939679; rs308326; rs308339; rs308340; rs3115545; rs3115546; rs3115548; rs3133266; rs3133267; rs3133269; rs3751085; rs3763942; rs3808969; rs3808970; rs3808971; rs4147776; rs4147777; rs4147778; rs4147780; rs4147782; rs479763; rs7949541; rs7951010; rs7952122; rs884826; rs999571

# Metabolic_Enzyme_7_General_References:
7828891

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5772

# Metabolic_Enzyme_8_Name:
Acetylcholinesterase precursor

# Metabolic_Enzyme_8_Synonyms:
AChE

# Metabolic_Enzyme_8_Gene_Name:
ACHE

# Metabolic_Enzyme_8_Protein_Sequence:
>Acetylcholinesterase precursor
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL

# Metabolic_Enzyme_8_Number_of_Residues:
614

# Metabolic_Enzyme_8_Molecular_Weight:
67797

# Metabolic_Enzyme_8_Theoretical_pI:
6.24

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  cholinesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Rapidly hydrolyzes choline released into the synapse

# Metabolic_Enzyme_8_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_8_Reaction:
acetylcholine + H2O = choline + acetate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF08674:AChE_tetra;
PF00135:COesterase

# Metabolic_Enzyme_8_Signals:
1-31

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.1.7

# Metabolic_Enzyme_8_GenBank_ID_Protein:
177975

# Metabolic_Enzyme_8_SwissProt_ID:
ACES_HUMAN (P22303)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
ACHE

# Metabolic_Enzyme_8_Geneatlas_id:
ACHE

# Metabolic_Enzyme_8_hgnc_id:
HGNC:108

# Metabolic_Enzyme_8_PDB_ID:
1F8U

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
M55040

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_8_Locus:
7q22

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2263619; 12853948; 11239002; 8299725; 2714437; 1748670; 1517212; 9640563; 11053835; 8488842

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5824

# Metabolic_Enzyme_9_Name:
Acylphosphatase-2

# Metabolic_Enzyme_9_Synonyms:
Acylphosphate phosphohydrolase 2; Acylphosphatase, muscle type isozyme

# Metabolic_Enzyme_9_Gene_Name:
ACYP2

# Metabolic_Enzyme_9_Protein_Sequence:
>Acylphosphatase2
MSTAQSLKSVDYEVFGRVQGVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVN
SMKSWLSKVGSPSSRIDRTNFSNEKTISKLEYSNFSIRY

# Metabolic_Enzyme_9_Number_of_Residues:
99

# Metabolic_Enzyme_9_Molecular_Weight:
11140

# Metabolic_Enzyme_9_Theoretical_pI:
10.01

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  acylphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_9_Specific_Function:
Its physiological role is not yet clear

# Metabolic_Enzyme_9_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00632  Benzoate degradation via CoA ligation

# Metabolic_Enzyme_9_Reaction:
An acylphosphate + H2O = a carboxylate + phosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00708:Acylphosphatase

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.6.1.7

# Metabolic_Enzyme_9_GenBank_ID_Protein:
15341747

# Metabolic_Enzyme_9_SwissProt_ID:
ACYP2_HUMAN (P14621)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
ACYP2

# Metabolic_Enzyme_9_Geneatlas_id:
ACYP2

# Metabolic_Enzyme_9_hgnc_id:
HGNC:180

# Metabolic_Enzyme_9_PDB_ID:
1APS

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_9_Gene_Sequence:
>300 bp
ATGTCTACCGCCCAGTCACTCAAATCCGTGGACTACGAGGTGTTCGGAAGAGTGCAGGGT
GTTTGCTTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAGTGGTTGGCTGGGTG
AAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCAAT
TCCATGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAAC
TTTTCTAATGAAAAAACCATCTCTAAGCTTGAATACTCTAATTTTAGTATTAGATACTAA


# Metabolic_Enzyme_9_GenBank_ID_Gene:
BC012290

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_9_Locus:
2p16.2

# Metabolic_Enzyme_9_SNPs:
rs13405053; rs11980; rs843762; rs1001296; rs843722; rs1399513; rs843716; rs698752; rs843748; rs843747; rs860057; rs843687; rs1484692; rs843730; rs843731; rs698755; rs843758; rs843752; rs843713; rs843671; rs843717; rs698750; rs843682; rs1358366; rs698756; rs843692; rs843765; rs843754; rs843657; rs843684; rs843714; rs843740; rs843767; rs843718; rs843755; rs843689; rs843656; rs1215145; rs843711; rs11894205; rs7574376; rs7586592; rs4671872; rs698751; rs977784; rs6751105; rs843749; rs10201710; rs11896279; rs843655; rs11680886; rs843696; rs11886559; rs843759; rs1727504; rs843763; rs6721970; rs10175251; rs7604464; rs1877908; rs10188489; rs843732; rs1682108; rs1421618; rs843653; rs1727506; rs10439478; rs843695; rs3915270; rs843678; rs11125528; rs13399590; rs6718204; rs7572559; rs1569086; rs843652; rs843651; rs6545388; rs11891079; rs1421619; rs843694; rs843751; rs3738855; rs7566894; rs10186140; rs11125529; rs7579722; rs10173565; rs843672; rs7574477; rs1727522; rs843726; rs843739; rs843675; rs843715; rs12615793; rs11884229; rs843673; rs843699; rs2357954; rs843677; rs843743; rs7562908; rs7594400; rs11125526; rs11884327; rs1872328; rs7573491; rs843764; rs11884435; rs1682109; rs1872329; rs1215152; rs1215146; rs843646; rs843737; rs6545387; rs7571660; rs12615749; rs6713088; rs843691; rs4553857; rs843741; rs1215147; rs843647; rs843679; rs10181332; rs7586074; rs843719; rs17045575; rs6732970; rs7559380; rs11678184; rs843649; rs7567556; rs843698; rs843686; rs860056; rs13390377; rs843756; rs10191400; rs843685; rs2695649; rs4671890; rs11892920; rs12614774; rs6717823; rs1877909; rs13407957; rs11899522; rs843735; rs12612860; rs843654; rs843710; rs13412967; rs7568345; rs1817557; rs10184018; rs7593450; rs2042143; rs6713993; rs843666; rs843725; rs1351881; rs4671891; rs6736179; rs7607826; rs12622470; rs10195704; rs1075265; rs843680; rs6744662; rs843733; rs1682102; rs1877907; rs7569743; rs17045654; rs11897209; rs964092; rs11890390; rs843724; rs2010461; rs11689599; rs11682807; rs1215154; rs1235407; rs2628197; rs11899551; rs7564849; rs10171521; rs1385273; rs7607209; rs843746; rs1877906; rs6545386; rs2112127; rs843723; rs843727; rs6706363; rs843659; rs2048749; rs13407991; rs843663; rs1872327; rs12465259; rs12615044; rs1215148; rs10496029; rs843664; rs843729; rs843650; rs13417267; rs13417493; rs843645; rs13423698; rs3850348; rs13411098; rs11889533; rs11690064; rs1727505; rs1913622; rs2357955; rs10207549; rs10206181; rs1727507; rs1727501; rs1215149; rs13407896; rs7592069; rs7593099; rs13424638; rs1385274; rs13410397; rs4671889; rs13420347; rs2112124; rs843760; rs9808326; rs843688; rs1215153; rs1727527; rs843728; rs1559039; rs12621747; rs6727644; rs843662; rs2287639; rs11125525; rs7567614; rs11902901; rs17045546; rs10184099; rs10171249; rs1682120; rs10206954; rs2287641; rs7567816; rs7593897; rs17045788; rs12621038; rs843697; rs10865281; rs843648; rs1215150; rs6721034; rs6545389; rs11885441; rs7584265; rs13426910; rs12619484; rs698753; rs1682121; rs13425449; rs10199041; rs12475488; rs843766; rs6743897; rs13400028; rs12616857; rs17045688; rs4588227; rs17045664; rs13384747; rs11895053; rs10180053; rs13406537; rs7584514; rs13396186; rs843709; rs6716768; rs17045711; rs11683930; rs6760158; rs13413363; rs12713254; rs17045536; rs7602930; rs12616744; rs13419158; rs12613693; rs10170925; rs17045773; rs17045645; rs4328670; rs843720; rs1682118; rs13407815; rs11125522; rs843661; rs11884867; rs10174714; rs6761289; rs2287640; rs12477919; rs3912428; rs13395449; rs17045765; rs13394772; rs1215157; rs1682113; rs1001297; rs11896604; rs843738; rs4302250; rs9309254; rs11689088; rs3738854; rs17045543; rs10193846; rs2090182; rs17045588; rs843753; rs13353360; rs1682119; rs17045680; rs13414565; rs11893929; rs13427743; rs10209379; rs843745; rs7592680; rs17045655; rs17045769; rs843690; rs6742463; rs2090183; rs17045792; rs7584399; rs17189820; rs1215156; rs1215155; rs11901576; rs843768; rs7595149; rs10172580; rs12618994; rs11886475; rs1569087; rs843674; rs7592819; rs10207316; rs7560496; rs17045803; rs17045585; rs7574651; rs843744; rs1682107; rs1035353; rs17045684; rs4133471; rs843676; rs7567646; rs13425290; rs843742; rs17045787; rs843658; rs13396318; rs17045690; rs1215151; rs17268381; rs11903579; rs17045704; rs10199945; rs10169755; rs843721; rs1099252; rs17045595; rs11893663; rs17268409; rs13421331; rs1986036; rs13413850; rs2449902; rs11902945; rs7579965; rs13417064; rs17045642; rs1215143; rs2080813; rs17045754; rs2112125; rs1580432; rs13001916; rs10207892; rs10194689; rs1843183; rs6757204; rs6747753; rs7559101; rs17189799; rs1215141; rs12623320; rs17045583; rs13423204; rs13416234; rs860058; rs10211315; rs17045755; rs17189659; rs13392879; rs843683; rs13393792; rs13386073; rs11125524; rs13407966; rs11125521; rs843761; rs13386287; rs17045696; rs11684075; rs7581283; rs17045660; rs7585336; rs17045569; rs13425337; rs13413198; rs4488701; rs9631060; rs843734; rs17045658; rs17189680; rs10181309; rs10182300; rs1099254; rs7589516; rs11895807; rs11889244; rs17045807; rs4671860; rs4671861; rs12617094; rs12620359; rs15136; rs843750; rs6726868; rs11338704; rs36006148; rs10670241; rs1727525; rs7605100; rs865816; rs865233; rs6723496; rs34214502; rs6723759; rs10205866; rs10195643; rs1099438; rs13412332; rs10192858; rs13432937; rs35814615; rs36119237; rs1843182; rs36030528; rs4619647; rs28376376; rs35623615; rs10649402; rs1236955; rs34121604; rs34918873; rs11125523; rs13001000; rs1727509; rs34162000; rs1514917; rs28679598; rs968260; rs7355768; rs11675579; rs866860; rs10195032; rs35059715; rs864579; rs34272855; rs34668689; rs6742557; rs7572767; rs7567531; rs3069007; rs34243306; rs1682133; rs13396362; rs34857873; rs7601410; rs13399915; rs698754; rs34122735; rs7589185; rs10210106; rs10695158; rs34136976; rs10180404; rs10616367; rs1727519; rs1601292; rs843757; rs1727524; rs11305602; rs13396310; rs11322993; rs35874994; rs34263169; rs4640424; rs35993761; rs35351322; rs9808489; rs35126790; rs13013288; rs844550; rs13028157; rs28445376; rs10673805; rs13420388; rs13403112; rs2358018; rs1682114; rs33926142; rs10185153; rs36071043; rs1727508; rs13393807; rs10680039; rs3069004; rs28559613; rs34894347; rs10207830; rs7605664; rs7603499; rs6728889; rs34432551; rs1237253; rs28558411; rs13395143; rs10571898; rs10193027; rs863621; rs3071186; rs13420248; rs1682094; rs13020565; rs13424470; rs36086569; rs13423617; rs13401548; rs6757372; rs11694461; rs34653284; rs10542497; rs5831291; rs35953014; rs1421620; rs17268276; rs10596948; rs1114007; rs13415762; rs6732104; rs11890605; rs28444585; rs11902367; rs13412139; rs36106602; rs13389240; rs34753426; rs1145513; rs13032125; rs34045950; rs1559040; rs864016; rs35174995; rs34429546; rs28489357; rs11310108; rs7355636; rs35951108; rs11903462; rs9807941; rs7592598; rs1682103; rs10172603; rs35068363; rs34379601; rs34195032; rs13432911; rs13423383; rs1905638; rs10607204; rs2930556; rs866859; rs6756174; rs843712; rs13390178; rs10172581; rs1682112; rs35990346; rs13383434; rs34110148; rs1682134; rs34344329; rs35424255; rs13008511; rs13004174; rs10184091; rs1099253; rs34202269; rs34632511; rs10172490; rs28376974; rs35932805; rs1238472; rs35426698; rs33976712; rs28492826; rs1682111; rs7607356; rs28599574; rs34469593; rs34644415; rs3916753; rs35962804; rs965109; rs2950569; rs3069029; rs10613395; rs35049240; rs34049474; rs13385032; rs7355635; rs10575339; rs35795352; rs10171734; rs34083989; rs35041614; rs5831290; rs2695648; rs7592484; rs35309943; rs11892194; rs1215138; rs34016483; rs35144373; rs7559709; rs1727500; rs843736; rs35334336; rs35812338; rs34258585; rs6741257; rs13397248; rs35347104; rs7558688; rs13392982; rs2161084; rs35908785; rs34803791; rs7606116; rs34731839; rs1215142; rs10531789; rs1682110; rs34440168; rs6732202; rs13415033; rs2018870; rs7355609; rs11886703; rs35216105; rs843660; rs1102808; rs34126566; rs952908; rs35433308; rs34014331; rs1075264; rs28544104; rs4671869; rs10611682; rs11432765; rs35145998; rs17189792; rs2695647; rs13412697; rs33952945; rs34494353; rs843665; rs34931097; rs35554061; rs2112126; rs843693; rs2463352; rs11295809; rs34846937; rs13400567; rs7570803; rs11459799; rs843681; rs35444317; rs34900505; rs34398621; rs10588789; rs13427038; rs2161085; rs35947065; rs7577156; rs13024714; rs34782040; rs34400204; rs34716415; rs35924164; rs2695646; rs13421534; rs5831292; rs1238469; rs7560189; rs6723912; rs4671916; rs7588179; rs34339832; rs13389469; rs13423343; rs34519856; rs2672671; rs28404178; rs12988218; rs866389; rs865234; rs11897951; rs10192952; rs35991339; rs7355466; rs3898888; rs11675345; rs34841607; rs35606644; rs35112914; rs10193885; rs2628196; rs34439903; rs1215144; rs34836192; rs35482637; rs3832035; rs13385842; rs34285007; rs13393594; rs10190498; rs34554365; rs6712502; rs4671917; rs34195465; rs34359444; rs34361625; rs6720696; rs10669711; rs34394331; rs35641543; rs1215139; rs34343315; rs10172798; rs35309455; rs13404903; rs28594245; rs28563086; rs35652253; rs3071218; rs1727526; rs34490974; rs10185189; rs35340218; rs13413118; rs35299326; rs35936212; rs35112731; rs34381809; rs34819287; rs7422723; rs7594550; rs13019605; rs1215140; rs13415920; rs34530011; rs7586755; rs35886675; rs9973583; rs698749; rs7558041; rs28481646; rs6746552; rs866858; rs35167194; rs35295105; rs11360655; rs35171056; rs34205094; rs7565453; rs11414020; rs11445871; rs34810157; rs10534567; rs10165485; rs10176342; rs10176406; rs11674614; rs11888384; rs13005618; rs13034077; rs13390991; rs13401799; rs13411458; rs13424808; rs13428453; rs17039541; rs17039547; rs17045513; rs17189743; rs2287642; rs2287643; rs2287644; rs2287645; rs34338213; rs34433964; rs34567788; rs6715177; rs6724542; rs6735998; rs6740641; rs7562055; rs843638; rs843639; rs843700; rs843701; rs843702; rs843704; rs843705; rs843706; rs843707; rs863622; rs865817; rs866390; rs866861; rs918356; rs918357; rs929733; rs929734

# Metabolic_Enzyme_9_General_References:
6100723; 7487897

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5825

# Metabolic_Enzyme_10_Name:
Acylphosphatase-1

# Metabolic_Enzyme_10_Synonyms:
Acylphosphate phosphohydrolase 1; Acylphosphatase, organ-common type isozyme; Acylphosphatase, erythrocyte isozyme

# Metabolic_Enzyme_10_Gene_Name:
ACYP1

# Metabolic_Enzyme_10_Protein_Sequence:
>Acylphosphatase1
MAEGNTLISVDYEIFGKVQGVFFRKHTQAEGKKLGLVGWVQNTDRGTVQGQLQGPISKVR
HMQEWLETRGSPKSHIDKANFNNEKVILKLDYSDFQIVK

# Metabolic_Enzyme_10_Number_of_Residues:
99

# Metabolic_Enzyme_10_Molecular_Weight:
11261

# Metabolic_Enzyme_10_Theoretical_pI:
9.94

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  acylphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_10_Specific_Function:
Its physiological role is not yet clear

# Metabolic_Enzyme_10_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00632  Benzoate degradation via CoA ligation

# Metabolic_Enzyme_10_Reaction:
An acylphosphate + H2O = a carboxylate + phosphate

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00708:Acylphosphatase

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 3.6.1.7

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1834464

# Metabolic_Enzyme_10_SwissProt_ID:
ACYP1_HUMAN (P07311)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ACYP1

# Metabolic_Enzyme_10_Geneatlas_id:
ACYP1

# Metabolic_Enzyme_10_hgnc_id:
HGNC:179

# Metabolic_Enzyme_10_PDB_ID:
2ACY

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_10_Gene_Sequence:
>300 bp
ATGGCAGAGGGAAACACCCTGATATCAGTGGATTATGAAATTTTTGGGAAGGTGCAAGGG
GTGTTTTTCCGTAAGCATACTCAGGCTGAGGGTAAAAAGCTGGGATTGGTAGGCTGGGTC
CAGAACACTGACCGGGGCACAGTGCAAGGACAATTGCAAGGTCCAATCTCCAAGGTGCGT
CATATGCAGGAATGGCTTGAAACAAGAGGAAGTCCTAAATCACACATCGACAAAGCAAAC
TTCAACAATGAAAAAGTCATCTTGAAGTTGGATTACTCAGACTTCCAAATTGTAAAATAA


# Metabolic_Enzyme_10_GenBank_ID_Gene:
X84194

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_10_Locus:
14q24.3

# Metabolic_Enzyme_10_SNPs:
rs175505; rs175508; rs175512; rs10142770; rs10149551; rs10149362; rs10143132; rs10129657; rs10873275; rs175504; rs10438026; rs4312248; rs35265522; rs33946767; rs34696420; rs175509; rs34945501; rs35643666; rs4026176; rs35401825; rs175507; rs11623238; rs10549398; rs175513; rs175510; rs34805683; rs175506; rs175511; rs33920224; rs11845186; rs10136948; rs11546525; rs11556091; rs12050143; rs12432005; rs17102999; rs175080; rs175081; rs175082; rs175083; rs175084; rs175085; rs175498; rs175499; rs175500; rs175501; rs175502; rs17782839; rs2273162; rs28756977; rs28756981; rs28756986; rs28756987; rs28756988; rs28756991; rs28937870; rs28937871; rs3180779; rs34012003; rs34248766; rs3742778; rs4903278; rs7303

# Metabolic_Enzyme_10_General_References:
12508121; 3026468; 7796909

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5253

# Metabolic_Enzyme_11_Name:
Acyl-coenzyme A thioesterase 12

# Metabolic_Enzyme_11_Synonyms:
Acyl-CoA thioesterase 12; Acyl-CoA thioester hydrolase 12; Cytoplasmic acetyl-CoA hydrolase 1; CACH-1; hCACH-1; START domain-containing protein 12; StARD12

# Metabolic_Enzyme_11_Gene_Name:
ACOT12

# Metabolic_Enzyme_11_Protein_Sequence:
>Acylcoenzyme A thioesterase 12
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQ
FEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEK
IHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDDLIFDEEEGAVSTRG
TSVQSIELVLPPHANHHGNTFGGQIMAWMETVATISASRLCWAHPFLKSVDMFKFRGPST
VGDRLVFTAIVNNTFQTCVEVGVRVEAFDCQEWAEGRGRHINSAFLIYNAADDKENLITF
PRIQPISKDDFRRYRGAIARKRIRLGRKYVISHKEEVPLCIHWDISKQASLSDSNVEALK
KLAAKRGWEVTSTVEKIKIYTLEEHDVLSVWVEKHVGSPAHLAYRLLSDFTKRPLWDPHF
VSCEVIDWVSEDDQLYHITCPILNDDKPKDLVVLVSRRKPLKDGNTYTVAVKSVILPSVP
PSPQYIRSEIICAGFLIHAIDSNSCIVSYFNHMSASILPYFAGNLGGWSKSIEETAASCI
QFLENPPDDGFVSTF

# Metabolic_Enzyme_11_Number_of_Residues:
555

# Metabolic_Enzyme_11_Molecular_Weight:
62035

# Metabolic_Enzyme_11_Theoretical_pI:
6.76

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
Hydrolyzes acetyl-CoA to acetate and CoA

# Metabolic_Enzyme_11_Pathway:
map00620  Pyruvate metabolism

# Metabolic_Enzyme_11_Reaction:
acetyl-CoA + H2O = CoA + acetate

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF03061:4HBT;
PF01852:START

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.1.2.1

# Metabolic_Enzyme_11_GenBank_ID_Protein:
18307694

# Metabolic_Enzyme_11_SwissProt_ID:
ACO12_HUMAN (Q8WYK0)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ACOT12

# Metabolic_Enzyme_11_Geneatlas_id:
ACOT12

# Metabolic_Enzyme_11_hgnc_id:
HGNC:24436

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>1668 bp
ATGGAGCGGCCGGCGCCCGGCGAGGTGGTCATGAGCCAAGCCATCCAGCCGGCGCACGCC
ACTGCGCGCGGCGAGCTGAGCGCGGGGCAGCTGCTCAAGTGGATCGACACCACCGCCTGC
CTGGCGGCTGAGAAACATGCTGGAGTTTCCTGCGTTACAGCCTCAGTGGATGACATACAG
TTTGAGGAGACAGCTAGAGTTGGACAAGTTATAACCATCAAAGCAAAAGTTACTAGAGCA
TTCAGCACAAGCATGGAGATCAGTATCAAGGTCATGGTACAGGATATGCTCACTGGCATT
GAGAAGCTTGTTAGTGTGGCTTTCTCCACATTTGTAGCCAAACCAGTTGGAAAAGAAAAG
ATTCATTTAAAACCAGTCACACTTCTAACTGAACAAGATCATGTGGAACATAATCTGGCT
GCTGAGAGAAGGAAAGTTCGATTACAACATGAAGATACCTTTAACAATTTAATGAAGGAA
AGTAGCAAATTTGATGATCTCATTTTTGATGAAGAGGAAGGAGCGGTTTCCACAAGGGGC
ACCTCCGTTCAGAGCATTGAACTGGTCCTCCCACCCCATGCAAACCATCACGGAAATACA
TTTGGTGGCCAGATTATGGCGTGGATGGAGACAGTGGCTACTATTTCTGCAAGCCGCCTG
TGTTGGGCTCATCCCTTTCTGAAGTCCGTAGATATGTTTAAGTTCCGGGGACCATCTACA
GTTGGAGATCGTCTTGTCTTCACTGCCATTGTCAACAATACATTTCAGACCTGTGTTGAA
GTTGGAGTTCGCGTGGAGGCCTTTGACTGTCAGGAATGGGCCGAGGGCCGAGGGCGTCAC
ATCAACAGTGCTTTTCTCATTTACAATGCTGCTGATGATAAGGAAAATCTCATCACGTTT
CCCAGAATCCAACCCATTTCAAAGGATGATTTCAGACGCTATCGGGGAGCTATTGCACGC
AAGCGAATTCGCCTAGGCAGAAAATATGTTATTTCCCACAAAGAAGAGGTTCCACTTTGC
ATACACTGGGATATCAGCAAGCAGGCATCCCTGAGTGACAGCAATGTGGAGGCCCTCAAA
AAACTGGCAGCCAAAAGGGGTTGGGAGGTTACCAGCACTGTGGAAAAGATAAAAATATAT
ACTCTGGAAGAGCATGATGTTTTATCTGTTTGGGTTGAAAAGCACGTGGGAAGTCCAGCA
CATTTGGCTTATCGTCTCTTGTCTGACTTTACAAAGCGACCTTTGTGGGACCCCCATTTT
GTGTCCTGTGAAGTCATAGACTGGGTGAGTGAAGATGATCAGCTGTATCACATCACCTGT
CCTATACTGAATGATGACAAACCCAAAGACTTGGTAGTACTCGTATCACGAAGAAAACCC
CTCAAAGATGGTAACACTTACACAGTGGCAGTGAAGTCGGTCATTTTGCCATCGGTCCCC
CCGTCTCCACAGTACATCAGAAGTGAAATCATATGTGCCGGATTTCTCATCCATGCTATT
GACAGCAATTCATGCATCGTATCTTACTTTAACCATATGTCTGCTAGCATCCTTCCTTAC
TTTGCTGGAAATCTTGGTGGCTGGTCAAAATCCATTGAAGAAACAGCAGCCTCTTGTATA
CAGTTCTTAGAGAATCCTCCTGATGATGGGTTTGTAAGCACATTTTAA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
AB078619

# Metabolic_Enzyme_11_Chromosome_Location:
Not Available

# Metabolic_Enzyme_11_Locus:
Not Available

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
Not Available

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5271

# Metabolic_Enzyme_12_Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acyl- CoA synthetase short-chain family member 1

# Metabolic_Enzyme_12_Gene_Name:
ACSS1

# Metabolic_Enzyme_12_Protein_Sequence:
>Acetylcoenzyme A synthetase 2like, mitochondrial precursor
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

# Metabolic_Enzyme_12_Number_of_Residues:
689

# Metabolic_Enzyme_12_Molecular_Weight:
74857

# Metabolic_Enzyme_12_Theoretical_pI:
7.11

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

# Metabolic_Enzyme_12_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_12_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_12_Signals:
1-22

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_12_GenBank_ID_Protein:
56203089

# Metabolic_Enzyme_12_SwissProt_ID:
ACS2L_HUMAN (Q9NUB1)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ACSS1

# Metabolic_Enzyme_12_Geneatlas_id:
ACSS1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:16091

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_12_Gene_Sequence:
>1439 bp
CCAAGTGCAAGGTGGTTATCACCTTCAACCAAGGACTCCGGGGTGGGCGCGTGGTGGAGC
TGAAGAAAATAGTGGATGAGGCTGTGAAGCACTGCCCCACCGTGCAGCATGTCCTGGTGG
CTCACAGGACAGACAACAAGGTCCACATGGGGGATCTGGACGTCCCGCTGGAGCAGGAAA
TGGCCAAGGAGGACCCTGTTTGCGCCCCAGAGAGCATGGGCAGTGAGGACATGCTCTTCA
TGCTGTACACCTCAGGGAGCACCGGAATGCCCAAGGGCATCGTCCATACCCAGGCAGGCT
ACCTGCTCTATGCCGCCCTGACTCACAAGCTTGTGTTTGACCACCAGCCAGGTGACATCT
TTGGCTGTGTGGCCGACATCGGTTGGATTACAGGACACAGCTACGTGGTGTATGGGCCTC
TCTGCAATGGTGCCACCAGCGTCCTTTTTGAGAGCACCCCAGTTTATCCCAATGCTGGTC
GGTACTGGGAGACAGTAGAGAGGTTGAAGATCAATCAGTTCTATGGCGCCCCAACGGCTG
TCCGGCTGTTGCTGAAATACGGTGATGCCTGGGTGAAGAAGTATGATCGCTCCTCCCTGC
GGACCCTGGGGTCAGTGGGAGAGCCCATCAACTGTGAGGCCTGGGAGTGGCTTCACAGGG
TGGTGGGGGACAGCAGGTGCACGCTGGTGGACACCTGGTGGCAGACAGAAACAGGTGGCA
TCTGCATCGCACCACGGCCCTCGGAAGAAGGGGCGGAAATCCTCCCTGCCATGGCGATGA
GGCCCTTCTTTGGCATCGTCCCCGTCCTCATGGATGAGAAGGGCAGCGTCGTGGAGGGCA
GCAACGTCTCCGGGGCCCTGTGCATCTCCCAGGCCTGGCCGGGCATGGCCAGGACCATCT
ATGGCGACCACCAGCGATTTGTGGACGCCTACTTCAAGGCCTACCCAGGCTATTACTTCA
CTGGAGACGGGGCTTACCGAACTGAGGGCGGCTATTACCAGATCACAGGGCGGATGGATG
ATGTCATCAACATCAGTGGCCACCGGCTGGGGACCGCAGAGATTGAGGACGCCATCGCCG
ACCACCCTGCAGTACCAGAAAGTGCTGTCATTGGCTACCCCCACGACATCAAAGGAGAAG
CTGCCTTTGCCTTCATTGTGGTGAAAGATAGTGCGGGTGACTCAGATGTGGTGGTGCAGG
AGCTCAAGTCCATGGTGGCCACCAAGATCGCCAAATATGCTGTGCCTGATGAGATCCTGG
TGGTGAAACGTCTTCCAAAAACCAGGTCTGGGAAGGTCATGCGGCGGCTCCTGAGGAAGA
TCATCACTAGTGAGGCCCAGGAGCTGGGAGACACTACCACCTTGGAGGACCCCAGCATCA
TCGCAGAGATCCTGAGTGTCTACCAGAAGTGCAAGGACAAGCAGGCTGCTGCTAAGTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AL035661

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_12_Locus:
20p11.23-p11.21

# Metabolic_Enzyme_12_SNPs:
rs6050249; rs6115003; rs6050259; rs6115001; rs3746331; rs6114999; rs6132784; rs6083718; rs2294980; rs3646; rs3746332; rs8118803; rs6050261; rs6050266; rs7270236; rs6132785; rs11697253; rs11699487; rs6050255; rs8114108; rs910526; rs1007881; rs6138466; rs6115000; rs6083728; rs11908104; rs3746330; rs6050281; rs6138473; rs6050267; rs8124799; rs6115002; rs6115010; rs910527; rs4815363; rs6132792; rs11908037; rs6083725; rs761720; rs6050252; rs7263112; rs6132789; rs6115015; rs2144371; rs2179732; rs4815364; rs6106989; rs8121327; rs4815361; rs6050268; rs11698964; rs6083726; rs6037010; rs7271250; rs6076312; rs1015278; rs6138478; rs1985485; rs6037007; rs6515575; rs11699824; rs11907003; rs6050263; rs6106986; rs12624595; rs6138475; rs6050262; rs6083729; rs6083727; rs7273310; rs6050270; rs11907817; rs6138470; rs8119255; rs12481389; rs7268879; rs6138474; rs7273518; rs6050257; rs6115011; rs6083730; rs4813543; rs4392331; rs6115009; rs6115008; rs7265897; rs13039383; rs1960190; rs11698942; rs6115013; rs6050264; rs11907559; rs7262168; rs7266133; rs6106985; rs6050253; rs12480685; rs6037013; rs1555157; rs1555158; rs7273872; rs6138465; rs6138464; rs7268196; rs6114995; rs3928737; rs6050244; rs7273998; rs6037006; rs6114996; rs6114997; rs6050290; rs1973921; rs9967918; rs6083719; rs41308619; rs6050250; rs41315096; rs34418920; rs7265950; rs6050247; rs8118553; rs6050245; rs6050246; rs6050248; rs11349463; rs6114998; rs3746333; rs11556305; rs6138480; rs6037009; rs2024740; rs6083720; rs6050282; rs34106051; rs34040475; rs6138467; rs7265967; rs35754748; rs6106987; rs7347286; rs7268641; rs35918514; rs5841047; rs6050285; rs11908357; rs6132786; rs10667081; rs6050273; rs6050288; rs35440489; rs11475510; rs11087496; rs6050283; rs2235848; rs6083721; rs41315094; rs5841046; rs35370044; rs6132788; rs6050258; rs35022349; rs6132787; rs36083645; rs6037011; rs34821066; rs6138479; rs33974103; rs34478164; rs6138481; rs6083731; rs6115018; rs7363000; rs6138472; rs6050286; rs35714586; rs6115014; rs6083723; rs6050265; rs8123929; rs35559944; rs34768826; rs6050275; rs35187537; rs6132793; rs34248454; rs4813544; rs6050269; rs6115012; rs33947143; rs6083724; rs34068044; rs34114131; rs34202442; rs6050272; rs35419604; rs11474894; rs34478614; rs7272596; rs34772607; rs11696684; rs6132791; rs3086647; rs6106990; rs6138471; rs11469635; rs7265721; rs10701711; rs11699715; rs6050271; rs35841792; rs6050251; rs8114568; rs34766073; rs34911154; rs6050284; rs34012555; rs35888097; rs6132790; rs11472149; rs8123923; rs34740612; rs36081306; rs7270177; rs8182893; rs6037008; rs11473680; rs6050287; rs11480696; rs6138476; rs6050274; rs34340531; rs4815365; rs8184324; rs33955639; rs5841045; rs11482316; rs6050289; rs35994199; rs7271571; rs1005409; rs11905625; rs11905675; rs2207631; rs2387573; rs2387577; rs4239751; rs6050243; rs6050291; rs6083712; rs6083713; rs6083714; rs6114987; rs6114991; rs6138461; rs6138462; rs7274899

# Metabolic_Enzyme_12_General_References:
11780052; 11347906; 12168954

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5826

# Metabolic_Enzyme_13_Name:
Aminoacylase-1

# Metabolic_Enzyme_13_Synonyms:
N-acyl-L-amino-acid amidohydrolase; ACY-1

# Metabolic_Enzyme_13_Gene_Name:
ACY1

# Metabolic_Enzyme_13_Protein_Sequence:
>Aminoacylase1
MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVV
TVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQ
YLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANP
TDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSN
PHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEG
VTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPAL
GFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS

# Metabolic_Enzyme_13_Number_of_Residues:
408

# Metabolic_Enzyme_13_Molecular_Weight:
45885

# Metabolic_Enzyme_13_Theoretical_pI:
6.12

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  aminoacylase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate)

# Metabolic_Enzyme_13_Pathway:
map00220  Urea cycle and metabolism of amino groups

# Metabolic_Enzyme_13_Reaction:
An N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.5.1.14

# Metabolic_Enzyme_13_GenBank_ID_Protein:
178071

# Metabolic_Enzyme_13_SwissProt_ID:
ACY1_HUMAN (Q03154)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
ACY1

# Metabolic_Enzyme_13_Geneatlas_id:
ACY1

# Metabolic_Enzyme_13_hgnc_id:
HGNC:177

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>1227 bp
ATGACCAGCAAGGGTCCCGAGGAGGAGCACCCATCGGTGACGCTCTTCCGCCAGTACCTG
CGTATCCGCACTGTCCAGCCCAAGCCTGACTATGGAGCTGCTGTGGCTTTCTTTGAGGAG
ACAGCCCGCCAGCTGGGCCTGGGCTGTCAGAAAGTAGAGGTGGCACCTGGCTATGTGGTG
ACCGTGTTGACCTGGCCAGGCACCAACCCTACACTCTCCTCCATCTTGCTCAACTCCCAC
ACGGATGTGGTGCCTGTCTTCAAGGAACATTGGAGTCACGACCCCTTTGAGGCCTTCAAG
GATTCTGAGGGCTACATCTATGCCAGGGGTGCCCAGGACATGAAGTGCGTCAGCATCCAG
TACCTGGAAGCTGTGAGGAGGCTGAAGGTGGAGGGCCACCGGTTCCCCAGAACCATCCAC
ATGACCTTTGTGCCTGATGAGGAGGTTGGGGGTCACCAAGGCATGGAGCTGTTCGTGCAG
CGGCCTGAGTTCCACGCCCTGAGGGCAGGCTTTGCCCTGGATGAGGGCATAGCCAATCCC
ACTGATGCCTTCACTGTCTTTTATAGTGAGCGGAGTCCCTGGTGGGTGCGGGTTACCAGC
ACTGGGAGGCCAGGCCATGCCTCACGCTTCATGGAGGACACAGCAGCAGAGAAGCTGCAC
AAGGTTGTAAACTCCATCCTGGCATTCCGGGAGAAGGAATGGCAGAGGCTGCAGTCAAAC
CCCCACCTGAAAGAGGGGTCCGTGACCTCCGTGAACCTGACTAAGCTAGAGGGTGGCGTG
GCCTATAACGTGATACCTGCCACCATGAGCGCCAGCTTTGACTTCCGTGTGGCACCGGAT
GTGGACTTCAAGGCTTTTGAGGAGCAGCTGCAGAGCTGGTGCCAGGCAGCTGGCGAGGGG
GTCACCCTAGAGTTTGCTCAGAAGTGGATGCACCCCCAAGTGACACCTACTGATGACTCA
AACCCTTGGTGGGCAGCTTTTAGCCGGGTCTGCAAGGATATGAACCTCACTCTGGAGCCT
GAGATCATGCCTGCTGCCACTGACAACCGCTATATCCGCGCGGTGGGGGTCCCAGCTCTA
GGCTTCTCACCCATGAACCGCACACCTGTGCTGCTGCACGACCACGATGAACGGCTGCAT
GAGGCTGTGTTCCTCCGTGGGGTGGACATATATACACGCCTGCTGCCTGCCCTTGCCAGT
GTGCCTGCCCTGCCCAGTGACAGCTGA

# Metabolic_Enzyme_13_GenBank_ID_Gene:
L07548

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_13_Locus:
3p21.1

# Metabolic_Enzyme_13_SNPs:
rs887540; rs34017492; rs323894; rs323895; rs323892; rs323893; rs82854; rs887541; rs2229152; rs6804746; rs11544304; rs11457478; rs11442467; rs34491128; rs3211518; rs178917; rs41292352; rs35075916; rs34879976; rs11924757; rs35346203; rs34294622; rs34300686; rs34903202; rs323890; rs3178066; rs35275952; rs2015691; rs3178064; rs323858; rs323862; rs323863; rs323891; rs323896; rs323897; rs34118567; rs34149506; rs34991570; rs380788; rs3821828; rs404527; rs411209; rs433823; rs6446153; rs6768522; rs740923; rs7432986

# Metabolic_Enzyme_13_General_References:
8357837; 8394326

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5827

# Metabolic_Enzyme_14_Name:
Aspartoacylase

# Metabolic_Enzyme_14_Synonyms:
Aminoacylase-2; ACY-2

# Metabolic_Enzyme_14_Gene_Name:
ASPA

# Metabolic_Enzyme_14_Protein_Sequence:
>Aspartoacylase
MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
LTLNAKSIRCCLH

# Metabolic_Enzyme_14_Number_of_Residues:
313

# Metabolic_Enzyme_14_Molecular_Weight:
35736

# Metabolic_Enzyme_14_Theoretical_pI:
6.51

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids

# Metabolic_Enzyme_14_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_14_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_14_GenBank_ID_Protein:
455834

# Metabolic_Enzyme_14_SwissProt_ID:
ACY2_HUMAN (P45381)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
ASPA

# Metabolic_Enzyme_14_Geneatlas_id:
ASPA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:756

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_14_Gene_Sequence:
>942 bp
ATGACTTCTTGTCACATTGCTGAAGAACATATACAAAAGGTTGCTATCTTTGGAGGAACC
CATGGGAATGAGCTAACCGGAGTATTTCTGGTTAAGCATTGGCTAGAGAATGGCGCTGAG
ATTCAGAGAACAGGGCTGGAGGTAAAACCATTTATTACTAACCCCAGAGCAGTGAAGAAG
TGTACCAGATATATTGACTGTGACCTGAATCGCATTTTTGACCTTGAAAATCTTGGCAAA
AAAATGTCAGAAGATTTGCCATATGAAGTGAGAAGGGCTCAAGAAATAAATCATTTATTT
GGTCCAAAAGACAGTGAAGATTCCTATGACATTATTTTTGACCTTCACAACACCACCTCT
AACATGGGGTGCACTCTTATTCTTGAGGATTCCAGGAATAACTTTTTAATTCAGATGTTT
CATTACATTAAGACTTCTCTGGCTCCACTACCCTGCTACGTTTATCTGATTGAGCATCCT
TCCCTCAAATATGCGACCACTCGTTCCATAGCCAAGTATCCTGTGGGTATAGAAGTTGGT
CCTCAGCCTCAAGGGGTTCTGAGAGCTGATATCTTGGATCAAATGAGAAAAATGATTAAA
CATGCTCTTGATTTTATACATCATTTCAATGAAGGAAAAGAATTTCCTCCCTGCGCCATT
GAGGTCTATAAAATTATAGAGAAAGTTGATTACCCCCGGGATGAAAATGGAGAAATTGCT
GCTATCATCCATCCTAATCTGCAGGATCAAGACTGGAAACCACTGCATCCTGGGGATCCC
ATGTTTTTAACTCTTGATGGGAAGACGATCCCACTGGGCGGAGACTGTACCGTGTACCCC
GTGTTTGTGAATGAGGCCGCATATTACGAAAAGAAAGAAGCTTTTGCAAAGACAACTAAA
CTAACGCTCAATGCAAAAAGTATTCGCTGCTGTTTACATTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
S67156

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_14_Locus:
17pter-p13

# Metabolic_Enzyme_14_SNPs:
rs12948217; rs28940279; rs9896885; rs1873061; rs2131517; rs1488688; rs1493282; rs9902120; rs2035939; rs2029352; rs2029350; rs2035938; rs923376; rs9889588; rs9902229; rs4790496; rs6502727; rs923375; rs11652568; rs9916804; rs11869485; rs2318036; rs9904040; rs9910285; rs4790495; rs8068225; rs3786009; rs7215891; rs2029351; rs12948872; rs11651636; rs9904168; rs9901015; rs9906620; rs8065488; rs17762979; rs2279567; rs11868193; rs6502726; rs8071141; rs6502728; rs3744670; rs11656291; rs17222495; rs8068239; rs16953070; rs3786010; rs12051797; rs8066886; rs17222551; rs8075119; rs9899946; rs12601330; rs1964623; rs12941620; rs12946424; rs9889604; rs16953074; rs1971292; rs35002210; rs17175228; rs7220559; rs9941396; rs11078450; rs3829957; rs11078451; rs3814886; rs28940574; rs17850703; rs1552830; rs35730123; rs10524882; rs12937166; rs3837856; rs5818896; rs34680506; rs36034906; rs9894622; rs36051310; rs3037735; rs2318038; rs34109510; rs12602137; rs11380439; rs35614631; rs12943481; rs8072059; rs12952852; rs35178659; rs2318040; rs34015272; rs2200728; rs2318037; rs8066628; rs8081562; rs34744839; rs12951114; rs35225782; rs12936895; rs35095578; rs35629100; rs34365618; rs36033666; rs34002091; rs2318039; rs34054576; rs3215041; rs12603718; rs34275920; rs12945398; rs5818897; rs36225687; rs6145956; rs8069497; rs3039623; rs10521121; rs11649929; rs11653068; rs11656519; rs11657794; rs12450574; rs12602543; rs12940665; rs12946429; rs16953091; rs17822693; rs34838258; rs3786011; rs4790142; rs4790500; rs7209613; rs7211452; rs7216314; rs7217800; rs7220982; rs7221929; rs7223710; rs8065143; rs8065249; rs8075699; rs8079320; rs9890041

# Metabolic_Enzyme_14_General_References:
8252036; 12706335; 8023850; 7668285; 7599639; 9452117; 10564886; 10909858; 12638939; 12205125

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5810

# Metabolic_Enzyme_15_Name:
Aldehyde dehydrogenase 3B2

# Metabolic_Enzyme_15_Synonyms:
Aldehyde dehydrogenase 8

# Metabolic_Enzyme_15_Gene_Name:
ALDH3B2

# Metabolic_Enzyme_15_Protein_Sequence:
>Aldehyde dehydrogenase 3B2
MKDEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGNCVVLKPSE
ISQGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAAT
KHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLL
PALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVL
VDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERT
SSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEI
RYPPYTDWNQQLLRWGMGSQSCTLL

# Metabolic_Enzyme_15_Number_of_Residues:
385

# Metabolic_Enzyme_15_Molecular_Weight:
42670

# Metabolic_Enzyme_15_Theoretical_pI:
5.97

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_15_Specific_Function:
An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

# Metabolic_Enzyme_15_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism

# Metabolic_Enzyme_15_Reaction:
an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 1.2.1.5

# Metabolic_Enzyme_15_GenBank_ID_Protein:
1051281

# Metabolic_Enzyme_15_SwissProt_ID:
AL3B2_HUMAN (P48448)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ALDH3B2

# Metabolic_Enzyme_15_Geneatlas_id:
ALDH3B2

# Metabolic_Enzyme_15_hgnc_id:
HGNC:411

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Not Available

# Metabolic_Enzyme_15_Gene_Sequence:
>1158 bp
ATGAAGGATGAACCACGGTCCACGAACCTGTTCATGAAGCTGGACTCGGTCTTCATCTGG
AAGGAACCCTTTGGCCTGGTCCTCATCATCGCACCCTGGAACTACCCATTGAACCTGACC
CTGGTGCTCCTGGTGGGCACCCTCCCCGCAGGGAATTGCGTGGTGCTGAAGCCGTCAGAA
ATCAGCCAGGGCACAGAGAAGGTCCTGGCTGAGGTGCTGCCCCAGTACCTGGACCAGAGC
TGCTTTGCCGTGGTGCTGGGCGGACCCCAGGAGACAGGGCAGCTGCTAGAGCACAAGTTG
GACTACATCTTCTTCACAGGGAGCCCTCGTGTGGGCAAGATTGTCATGACTGCTGCCACC
AAGCACCTGACGCCTGTCACCCTGGAGCTGGGGGGCAAGAACCCCTGCTACGTGGACGAC
AACTGCGACCCCCAGACCGTGGCCAACCGCGTGGCCTGGTTCTGCTACTTCAATGCCGGC
CAGACCTGCGTGGCCCCTGACTACGTCCTGTGCAGCCCCGAGATGCAGGAGAGGCTGCTG
CCCGCCCTGCAGAGCACCATCACCCGTTTCTATGGCGACGACCCCCAGAGCTCCCCAAAC
CTGGGCCGCATCATCAACCAGAAACAGTTCCAGCGGCTGCGGGCATTGCTGGGCTGCGGC
CGCGTGGCCATTGGGGGCCAGAGCAACGAGAGCGATCGCTACATCGCCCCCACGGTGCTG
GTGGACGTGCAGGAGACGGAGCCTGTGATGCAGGAGGAGATCTTCGGGCCCATCCTGCCC
ATCGTGAACGTGCAGAGCGTGGACGAGGCCATCAAGTTCATCAACCGGCAGGAGAAGCCC
CTGGCCCTGTACGCCTTCTCCAACAGCAGACAGGTTGTGAACCAGATGCTGGAGCGGACC
AGCAGCGGCAGCTTTGGAGGCAATGAGGGCTTCACCTACATATCTCTGCTGTCCGTGCCA
TTCGGGGGAGTCGGCCACAGTGGGATGGGCCGGTACCACGGCAAGTTCACCTTCGACACC
TTCTCCCACCACCGCACCTGCCTGCTCGCCCCCTCCGGCCTGGAGAAATTAAAGGAGATC
CGCTACCCACCCTATACCGACTGGAACCAGCAGCTGTTACGCTGGGGCATGGGCTCCCAG
AGCTGCACCCTCCTGTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
U37519

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_15_Locus:
11q13

# Metabolic_Enzyme_15_SNPs:
rs3741178; rs1551888; rs4646826; rs6591270; rs1551886; rs3741172; rs2279123; rs2279124; rs17510687; rs4313593; rs3127; rs1551885; rs3808972; rs2279125; rs1903829; rs866907; rs7947978; rs11823098; rs7114210; rs2514061; rs2251277; rs6591274; rs6591273; rs4646823; rs3825021; rs28372760; rs2279126; rs6591272; rs7947754; rs5019163; rs1871031; rs4930471; rs2514063; rs4569014; rs4930472; rs12295420; rs2251281; rs10791909; rs9787887; rs6591271; rs9736142; rs3741179; rs2514060; rs4930465; rs1551887; rs1871032; rs1979376; rs1979375; rs11603033; rs6591269; rs7934566; rs11821703; rs2514056; rs2514057; rs1140670; rs2447571; rs12292126; rs1131740; rs12278968; rs17856219; rs1051493; rs4646818; rs2514019; rs4587733; rs7483770; rs4646821; rs28887499; rs2447570; rs2514058; rs35431164; rs7944424; rs34589365; rs3191912; rs2514059; rs34763154; rs2514062; rs4930474; rs4646820; rs4581451; rs4646822; rs35843427; rs34926854; rs34057662; rs12361092; rs35632190; rs35691462; rs4646819; rs7483773; rs12288316; rs2447598; rs35605762; rs36154763; rs1131725; rs12272679; rs3928535; rs4930475; rs5019164; rs2447593; rs11227878; rs4646827; rs2126716; rs12285813; rs7943880; rs28819504; rs34264835; rs3741177; rs5792425; rs12807294; rs4244825; rs4646824; rs5792424; rs4646825; rs33990300; rs11826930; rs12574701; rs12294545; rs11824747; rs10736660; rs11828473; rs12272021; rs12288023; rs12363825; rs2054409; rs2447597; rs2509720; rs2514024; rs2514025; rs2885171; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267; rs7108411

# Metabolic_Enzyme_15_General_References:
7484374; 8890755

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5321

# Metabolic_Enzyme_16_Name:
Serum paraoxonase/lactonase 3

# Metabolic_Enzyme_16_Synonyms:
Not Available

# Metabolic_Enzyme_16_Gene_Name:
PON3

# Metabolic_Enzyme_16_Protein_Sequence:
>Serum paraoxonase/lactonase 3
MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS
GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFI
DKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYAT
RDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVA
AKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG
SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL

# Metabolic_Enzyme_16_Number_of_Residues:
354

# Metabolic_Enzyme_16_Molecular_Weight:
39608

# Metabolic_Enzyme_16_Theoretical_pI:
5.10

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents

# Metabolic_Enzyme_16_Pathway:
Not Available

# Metabolic_Enzyme_16_Reaction:
Not Available

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_16_Signals:
1-

# Metabolic_Enzyme_16_Transmembrane_Regions:
5-24

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_16_GenBank_ID_Protein:
12751374

# Metabolic_Enzyme_16_SwissProt_ID:
PON3_HUMAN (Q15166)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PON3

# Metabolic_Enzyme_16_Geneatlas_id:
PON3

# Metabolic_Enzyme_16_hgnc_id:
HGNC:9206

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_16_Gene_Sequence:
>1064 bp
ATGGGGAAGCTCGTGGCGCTGGTCCTGCTGGGGGTCGGCCTGTCCTTAGTCGGGGAGATG
TTCCTGGCGTTTAGAGAAAGGGTGAATGCCTCTCGAGAAGTGGAGCCAGTAGAACCTGAA
AACTGCCACCTTATTGAGGAACTTGAAAGTGGCTCTGAAGATATTGATATATTCCTCAGT
GGGCTGGCTTTTATCTCCAGTGGATTAAAATATCCAGGCATGCCAAACTTTGCGCCAGAT
GAACCAGGAAAAATCTTCTTGATGGATCTGAATGAACAAAACCCAAGGGCACAAGCACTA
GAAATCAGTGGTGGATTTGACAAAGAATTATTTAATCCACATGGGATCAGTATTTTCATC
GACAAAGACAATACTGTGTATCTTTATGTTGTGAATCATCCCCACATGAAGTCCACTGTG
GAGATATTTAAATTTGAGGAACAACAACGTTCTCTGGTATACCTGAAAACTATAAAACAT
GAACTTCTCAAAAGTGTGAATGACATTGTGGTTCTTGGACCAGAACAGTTCTATGCCACC
AGAGACCACTATTTTACCAACTCCCTCCTGTCATTTTTTGAGATGATCTTGGATCTTCGC
TGGACTTATGTTCTTTTCTACAGCCCAAGGGAGGTTAAAGTGGTGGCCAAAGGATTTTGT
AGTGCCAATGGGATCACAGTCTCAGCAGACCAGAAGTATGTCTATGTAGCTGATGTAGCA
GCTAAGAACATTCACATAATGGAAAAACATGATAACTGGGATTTAACTCAACTGAAGGTG
ATACAGTTGGGCACCTTAGTGGATAACCTGACTGTCGATCCTGCCACAGGAGACATTTTG
GCAGGATGCCATCCTAATCCTATGAAGCTACTGAACTATAACCCTGAGGACCCTCCAGGA
TCAGAAGTACTTCGCATCCAGAATGTTTTGTCTGAGAAGCCCAGGGTGAGCACCGTGTAT
GCCAACAATGGCTCTGTGCTTCAGGGCACCTCTGTGGCTTCTGTGTACCATGGGAAAATT
CTCATAGGCACCGTATTTCACAAAACTCTGTACTGTGAGCTCTA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AF320003

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_16_Locus:
7q21.3

# Metabolic_Enzyme_16_SNPs:
rs17883013; rs1053275; rs13226149; rs17879114; rs17885558; rs757905; rs2375002; rs740264; rs11980413; rs6977389; rs2074353; rs11970910; rs2057682; rs468; rs7779960; rs9641162; rs10808092; rs6946761; rs2074352; rs7807131; rs3757708; rs12534317; rs10487131; rs17884000; rs10953145; rs7778771; rs978903; rs3735587; rs10953143; rs10487132; rs7797694; rs10953146; rs17166859; rs11972988; rs17166861; rs7787187; rs11768074; rs17886518; rs17882874; rs17774169; rs17883750; rs17882656; rs17878595; rs17885520; rs17880412; rs17881310; rs17879649; rs17881183; rs17885341; rs10239444; rs7796605; rs17879692; rs17879725; rs17879891; rs17884104; rs17878798; rs1987726; rs17886074; rs7798025; rs17884044; rs17885396; rs17878924; rs17882417; rs17881155; rs17879131; rs17879949; rs10239294; rs17879761; rs17883791; rs17879931; rs17878619; rs17885715; rs17882644; rs9640632; rs17881059; rs17883258; rs17880289; rs2079444; rs17880600; rs17886059; rs17879480; rs2375004; rs17878661; rs17879129; rs17886092; rs2072199; rs17885294; rs17885614; rs17882955; rs17881085; rs17878952; rs17882519; rs17878448; rs11978302; rs17885157; rs17166860; rs2072200; rs11764079; rs11770903; rs11767787; rs17166858; rs17886036; rs17886586; rs17885453; rs17882539; rs17885439; rs17884226; rs1006522; rs17879866; rs17878827; rs2375003; rs17880470; rs17885576; rs17883235; rs17879616; rs35073929; rs4014704; rs17885577; rs17879584; rs11433699; rs12704793; rs17878647; rs17883838; rs17883824; rs13226415; rs17880986; rs4590372; rs17883077; rs17878893; rs7802498; rs17881614; rs4470943; rs10429065; rs4729188; rs35486199; rs35097770; rs35206180; rs17883761; rs36200982; rs17878638; rs17880217; rs36200976; rs17879939; rs17879079; rs17883823; rs17885861; rs17882341; rs35007097; rs34704069; rs17882691; rs1003504; rs34779716; rs17883276; rs17885214; rs17881251; rs12112856; rs17885374; rs4425687; rs34107793; rs17882562; rs17883078; rs34063317; rs17880176; rs2079443; rs17878870; rs17881120; rs35510461; rs34251122; rs34277693; rs17885966; rs34582490; rs17885651; rs28806617; rs17882411; rs11378129; rs17885907; rs17879069; rs17883550; rs17879912; rs34625078; rs17885924; rs12539168; rs34323584; rs13226339; rs17879836; rs11388951; rs17880498; rs17884011; rs17882643; rs17883723; rs10487130; rs10953142; rs11972564; rs11977702; rs11981299; rs13306702; rs17166845; rs17166850; rs17166854; rs17166856; rs17879277; rs17879517; rs34305047; rs3735586; rs4141217; rs7493; rs7785846; rs7794850; rs916864; rs9641161; rs9641164

# Metabolic_Enzyme_16_General_References:
12853948; 8661009

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5828

# Metabolic_Enzyme_17_Name:
Platelet-activating factor acetylhydrolase IB subunit alpha

# Metabolic_Enzyme_17_Synonyms:
PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1

# Metabolic_Enzyme_17_Gene_Name:
PAFAH1B1

# Metabolic_Enzyme_17_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit alpha
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR

# Metabolic_Enzyme_17_Number_of_Residues:
410

# Metabolic_Enzyme_17_Molecular_Weight:
46638

# Metabolic_Enzyme_17_Theoretical_pI:
7.40

# Metabolic_Enzyme_17_GO_Classification:
Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing

# Metabolic_Enzyme_17_Pathway:
Not Available

# Metabolic_Enzyme_17_Reaction:
Not Available

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF08513:LisH;
PF00400:WD40

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_17_GenBank_ID_Protein:
349824

# Metabolic_Enzyme_17_SwissProt_ID:
LIS1_HUMAN (P43034)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
PAFAH1B1

# Metabolic_Enzyme_17_Geneatlas_id:
PAFAH1B1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:8574

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasm. Spindle. Nucleus; nuclear membrane (Potential). Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane

# Metabolic_Enzyme_17_Gene_Sequence:
>1233 bp
ATGGTGCTGTCCCAGAGACAACGAGATGAACTAAATCGAGCTATAGCAGATTATCTTCGT
TCAAATGGCTATGAAGAGGCATATTCAGTTTTTAAAAAGGAAGCTGAATTAGATGTGAAT
GAAGAATTAGATAAAAAGTATGCTGGTCTTTTGGAAAAAAAATGGACATCTGTTATTAGA
TTACAAAAGAAGGTTATGGAATTAGAATCAAAGCTAAATGAAGCAAAAGAAGAATTTACG
TCAGGTGGACCTCTTGGTCAGAAACGAGACCCAAAAGAATGGATTCCCCGTCCGCCAGAA
AAATATGCATTGAGTGGTCACAGGAGTCCAGTCACTCGAGTCATTTTCCATCCTGTGTTC
AGTGTTATGGTCTCTGCTTCAGAGGATGCTACAATTAAGGTGTGGGATTATGAGACTGGA
GATTTTGAACGAACTCTTAAAGGACATACAGACTCTGTACAGGACATTTCATTCGACCAC
AGCGGCAAGCTTCTGGCTTCCTGTTCTGCAGATATGACCATTAAACTATGGGATTTTCAG
GGCTTTGAATGCATCAGAACCATGCACGGCCATGACCACAATGTTTCTTCAGTAGCCATC
ATGCCCAATGGAGATCATATAGTGTCTGCCTCAAGGGATAAAACTATAAAAATGTGGGAA
GTGCAAACTGGCTACTGTGTGAAGACATTCACAGGACACAGAGAATGGGTACGTATGGTA
CGGCCAAATCAAGATGGCACTCTGATAGCCAGCTGTTCCAATGACCAGACTGTGCGTGTA
TGGGTCGTAGCAACAAAGGAATGCAAGGCTGAGCTCCGAGAGCATGAGCATGTGGTAGAA
TGCATTTCCTGGGCTCCAGAAAGCTCATATTCCTCCATCTCTGAAGCAACAGGATCTGAG
ACTAAAAAAAGTGGTAAACCTGGGCCATTCTTGCTGTCTGGATCCAGAGACAAGACTATT
AAGATGTGGGATGTCAGTACTGGCATGTGCCTTATGACCCTCGTGGGTCATGATAACTGG
GTACGTGGAGTTCTGTTCCATTCTGGGGGGAAGTTTATTTTGAGTTGTGCTGATGACAAG
ACCCTACGCGTATGGGATTACAAGAACAAGCGATGCATGAAGACCCTCAATGCGCATGAA
CACTTTGTTACCTCCTTGGATTTCCACAAGACGGCACCCTATGTCGTCACTGGCAGCGTA
GATCAAACAGTAAAAGTGTGGGAGTGCCGTTGA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
L13385

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_17_Locus:
17p13.3

# Metabolic_Enzyme_17_SNPs:
rs1266475; rs6628; rs867092; rs7209748; rs11078280; rs9905797; rs1266470; rs9897253; rs2439998; rs16952324; rs9899704; rs11078281; rs7213173; rs6502385; rs10445281; rs9908889; rs4790356; rs9908626; rs9911447; rs7214105; rs11870877; rs12452637; rs7209407; rs12450893; rs8068673; rs7217392; rs8079534; rs12943652; rs9902409; rs9908610; rs12449668; rs12449535; rs8074698; rs6502400; rs8071069; rs1266471; rs1266474; rs2531855; rs2317293; rs11867265; rs2439997; rs8068571; rs7211338; rs7209087; rs10445259; rs9889349; rs12451340; rs9908515; rs2439996; rs8077856; rs4556824; rs7216462; rs7209580; rs7216860; rs8072378; rs12453353; rs2531856; rs11078273; rs8077732; rs2317297; rs1029743; rs1029744; rs7213463; rs2873426; rs12938775; rs7223411; rs7211841; rs758416; rs8081803; rs4790353; rs3213696; rs8064409; rs12602021; rs12453812; rs8077351; rs12941261; rs3785957; rs6502440; rs6502442; rs4790089; rs3785958; rs11078300; rs9910645; rs7207614; rs11078288; rs9894388; rs12450337; rs4790355; rs9910332; rs12450722; rs11078302; rs3213697; rs7213741; rs16952298; rs11871331; rs7223817; rs12603072; rs11078286; rs4790348; rs16952275; rs9908283; rs7225921; rs7207987; rs4790087; rs8067871; rs6502458; rs7211181; rs9908050; rs768064; rs7224765; rs4609889; rs12051777; rs16952294; rs9908658; rs8082331; rs7210936; rs8077138; rs12150218; rs9908064; rs12450481; rs7207159; rs11078285; rs7219436; rs6502460; rs8067353; rs12936143; rs7215780; rs7209145; rs7219416; rs12051858; rs8070018; rs4790352; rs6502449; rs7225738; rs7216704; rs4362427; rs16952308; rs1803915; rs11652104; rs10606544; rs12947002; rs34761973; rs12946581; rs8076702; rs1803914; rs8797; rs34116093; rs1063474; rs35041946; rs12941801; rs2873425; rs1050060; rs10712058; rs34513110; rs35382225; rs34471859; rs34224166; rs12939922; rs34932981; rs34032623; rs9897737; rs10690714; rs34683975; rs34083323; rs12946469; rs9900665; rs34068430; rs12944570; rs12942112; rs34432210; rs11361437; rs8065991; rs11867971; rs8064881; rs1803913; rs12452806; rs11432432; rs34280283; rs1266472; rs34818326; rs34817885; rs35852637; rs3213695; rs9674719; rs35954533; rs12939921; rs12103775; rs35847789; rs11445169; rs16952273; rs11867972; rs1050061; rs34411981; rs34442256; rs35408383; rs1266473; rs2317295; rs35496270; rs7224954; rs35849869; rs35567602; rs13343274; rs34898826; rs4790090; rs1803912; rs12452821; rs1049972; rs34840132; rs12944558; rs35434180; rs34641583; rs34435220; rs12945881; rs5818872; rs3029954; rs7221255; rs2317296; rs11396911; rs11394999; rs4790088; rs12950917; rs8068466; rs12947700; rs34079979; rs35854143; rs8080733; rs35831029; rs35081573; rs35905116; rs34643970; rs5818869; rs34948212; rs12946135; rs12051903; rs35907473; rs10599416; rs9797251; rs36008138; rs11434541; rs11428423; rs6502438; rs34838213; rs7223347; rs12943545; rs35332619; rs34972908; rs7219015; rs34997708; rs34038838; rs28583520; rs12943572; rs7212391; rs34591445; rs2301165; rs35801835; rs35391038; rs4790354; rs8080128; rs35632355; rs34267097; rs11445148; rs11868182; rs11385415; rs34302417; rs12944429; rs1142073; rs8070312; rs34241880; rs12951200; rs28423027; rs35673615; rs12948200; rs12947683; rs35191721; rs35722835; rs7212585; rs8075918; rs35847684; rs8074193; rs34291491; rs2058165; rs35065867; rs10639352; rs10582467; rs11394286; rs11439238; rs9908744; rs34334771; rs8067153; rs35904559; rs35463848; rs34088886; rs34493806; rs7221826; rs5818871; rs10688067; rs35740513; rs12051672; rs35606899; rs10667274; rs8074558; rs11354575; rs11397532; rs4790349; rs11299400; rs33938135; rs10580602; rs7218235; rs5818870; rs34906915; rs35556974; rs11653772; rs34069179; rs34857040; rs34276555; rs1003398; rs1003399; rs1045864; rs1109451; rs2240730; rs2240731; rs2240732; rs3210638; rs35509306; rs35994060; rs4790357; rs7212450; rs9635678; rs9893575; rs9900415

# Metabolic_Enzyme_17_General_References:
8355785; 9063735; 11163258; 11889140; 11940666; 10441340; 11502906

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5780

# Metabolic_Enzyme_18_Name:
Platelet-activating factor acetylhydrolase IB subunit beta

# Metabolic_Enzyme_18_Synonyms:
PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta

# Metabolic_Enzyme_18_Gene_Name:
PAFAH1B2

# Metabolic_Enzyme_18_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit beta
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWR
ELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEA
IVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFV
HSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA

# Metabolic_Enzyme_18_Number_of_Residues:
229

# Metabolic_Enzyme_18_Molecular_Weight:
25570

# Metabolic_Enzyme_18_Theoretical_pI:
5.80

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit

# Metabolic_Enzyme_18_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_18_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00657:Lipase_GDSL

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_18_GenBank_ID_Protein:
2081614

# Metabolic_Enzyme_18_SwissProt_ID:
PA1B2_HUMAN (P68402)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
PAFAH1B2

# Metabolic_Enzyme_18_Geneatlas_id:
PAFAH1B2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:8575

# Metabolic_Enzyme_18_PDB_ID:
1FXW

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_18_Gene_Sequence:
>690 bp
ATGAGCCAAGGAGACTCAAACCCAGCAGCTATTCCGCATGCAGCAGAAGATATTCAAGGA
GATGACCGATGGATGTCTCAGCACAACAGATTTGTTTTGGACTGTAAAGACAAAGAGCCT
GATGTACTGTTCGTGGGAGACTCCATGGTGCAGTTAATGCAGCAATATGAGATATGGCGA
GAGCTTTTTTCCCCACTTCATGCACTGAATTTTGGAATTGGGGGAGATACAACAAGACAT
GTTTTGTGGAGACTAAAGAATGGAGAACTGGAGAATATTAAGCCTAAGGTCATTGTTGTC
TGGGTAGGAACAAATAACCACGAAAATACAGCAGAAGAAGTAGCAGGTGGGATCGAGGCC
ATTGTACAACTTATCAACACAAGGCAGCCACAGGCCAAAATCATTGTATTGGGTTTGTTA
CCTCGAGGTGAGAAACCCAATCCTTTGAGGCAAAAGAACGCCAAGGTGAACCAACTCCTC
AAGGTTTCGCTGCCGAAGCTTGCCAACGTGCAGCTCCTGGATACCGACGGGGGTTTTGTG
CACTCGGACGGTGCCATCTCCTGCCACGACATGTTTGATTTTCTGCATCTGACAGGAGGG
GGCTATGCAAAGATCTGCAAACCCCTGCATGAACTGATCATGCAGTTGTTGGAGGAAACA
CCTGAGGAGAAACAAACCACCATTGCCTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
D63390

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_18_Locus:
11q23

# Metabolic_Enzyme_18_SNPs:
rs4938349; rs12419436; rs4938347; rs12420725; rs12419227; rs4938350; rs7116454; rs2008908; rs2306471; rs4938348; rs7115562; rs10466592; rs4936365; rs12417984; rs12275933; rs12287494; rs12419272; rs4938351; rs10892079; rs1871757; rs2127905; rs10790175; rs6589602; rs7122944; rs7112513; rs3736120; rs10790174; rs7940310; rs7123517; rs7950633; rs7128382; rs12291885; rs7931335; rs4936366; rs4938352; rs10892080; rs7924389; rs12420250; rs12418896; rs2622934; rs11216304; rs11216297; rs34452623; rs1842567; rs35697010; rs9971561; rs7938902; rs35565601; rs12279830; rs36063971; rs35147963; rs34339279; rs35795118; rs11420191; rs11464993; rs35543434; rs2735183; rs11449159; rs34799596; rs12281315; rs10466591; rs34729840; rs11448584; rs11463525; rs35084965; rs7109311; rs11216303; rs4288786; rs12271743; rs11216302; rs35139041; rs28606431; rs12800789; rs34086293; rs7940225; rs11327233; rs35065382; rs35641654; rs35812569; rs35900647; rs12281009; rs7940106; rs12794352; rs34309794; rs35090192; rs35520143; rs12420127; rs11216298; rs7482529; rs12287258; rs33974219; rs11216300; rs36017397; rs12418349; rs35039449; rs35412232; rs11343000; rs35500922; rs7939981; rs11418579; rs34197273; rs11216306; rs11216307; rs11216308; rs35312964; rs11216305; rs34713157; rs11216295; rs11216296; rs10892082; rs10892083; rs2622936; rs3741295; rs4936367; rs4938353; rs7112577

# Metabolic_Enzyme_18_General_References:
9144386

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5777

# Metabolic_Enzyme_19_Name:
Platelet-activating factor acetylhydrolase IB subunit gamma

# Metabolic_Enzyme_19_Synonyms:
PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma

# Metabolic_Enzyme_19_Gene_Name:
PAFAH1B3

# Metabolic_Enzyme_19_Protein_Sequence:
>Plateletactivating factor acetylhydrolase IB subunit gamma
MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRE
LFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAI
VQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVH
SDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP

# Metabolic_Enzyme_19_Number_of_Residues:
231

# Metabolic_Enzyme_19_Molecular_Weight:
25735

# Metabolic_Enzyme_19_Theoretical_pI:
6.84

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Not Available

# Metabolic_Enzyme_19_Specific_Function:
Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain

# Metabolic_Enzyme_19_Pathway:
map00564  Glycerophospholipid metabolism

# Metabolic_Enzyme_19_Reaction:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00657:Lipase_GDSL

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.1.1.47

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1122219

# Metabolic_Enzyme_19_SwissProt_ID:
PA1B3_HUMAN (Q15102)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
PAFAH1B3

# Metabolic_Enzyme_19_Geneatlas_id:
PAFAH1B3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:8576

# Metabolic_Enzyme_19_PDB_ID:
1FXW

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_19_Gene_Sequence:
>696 bp
ATGAGTGGAGAGGAGAACCCAGCCAGCAAGCCCACGCCGGTGCAGGACGTACAGGGCGAC
GGGCGCTGGATGTCCCTGCACCATCGGTTCGTGGCTGACAGCAAAGATAAGGAACCCGAA
GTCGTCTTCATCGGGGACTCCTTGGTCCAGCTCATGCACCAGTGCGAGATCTGGCGCGAG
CTCTTCTCTCCTCTGCATGCACTTAACTTTGGCATTGGTGGTGACGGCACACAGCATGTA
CTGTGGCGGCTGGAGAATGGGGAGCTGGAACACATCCGGCCCAAGATTGTGGTGGTCTGG
GTGGGCACCAACAACCACGGACACACAGCAGAGCAGGTGACTGGTGGCATCAAGGCCATT
GTGCAACTGGTGAATGAGCGACAGCCCCAGGCCCGGGTTGTGGTGCTGGGCCTGCTTCCG
CGAGGCCAACATCCCAACCCACTTCGGGAGAAGAACCGACAGGTGAACGAGCTGGTACGG
GCGGCACTGGCTGGCCACCCTCGGGCCCACTTCCTAGATGCCGACCCTGGCTTTGTGCAC
TCAGATGGCACCATCAGCCATCATGACATGTATGATTACCTGCATCTGAGCCGCCTGGGC
TACACACCTGTTTGCCGGGCTCTGCACTCCCTGCTTCTGCGTCTGCTGGCCCAAGACCAG
GGCCAAGGTGCTCCCCTGCTGGAGCCCGCACCCTAA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
D63391

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_19_Locus:
19q13.1

# Metabolic_Enzyme_19_SNPs:
Not Available

# Metabolic_Enzyme_19_General_References:
7669037

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5532

# Metabolic_Enzyme_20_Name:
Aldehyde dehydrogenase X, mitochondrial precursor

# Metabolic_Enzyme_20_Synonyms:
Aldehyde dehydrogenase family 1 member B1; ALDH class 2

# Metabolic_Enzyme_20_Gene_Name:
ALDH1B1

# Metabolic_Enzyme_20_Protein_Sequence:
>Aldehyde dehydrogenase X, mitochondrial precursor
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

# Metabolic_Enzyme_20_Number_of_Residues:
517

# Metabolic_Enzyme_20_Molecular_Weight:
57239

# Metabolic_Enzyme_20_Theoretical_pI:
6.79

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_20_Specific_Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

# Metabolic_Enzyme_20_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_20_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_20_Signals:
1-22

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_20_GenBank_ID_Protein:
1263008

# Metabolic_Enzyme_20_SwissProt_ID:
AL1B1_HUMAN (P30837)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
ALDH1B1

# Metabolic_Enzyme_20_Geneatlas_id:
ALDH1B1

# Metabolic_Enzyme_20_hgnc_id:
HGNC:407

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_20_Gene_Sequence:
>1554 bp
ATGCTGCGCTTCCTGGCACCCCGGCTGCTTAGCCTCCAGGGCAGGACCGCCCTCTACTCC
TCGGCAGCAGCCCTCCCAAGCCCCATTCTGAACCCAGACATCCCCTACAACCAGCTGTTC
ATCAACAATGAATGGCAAGATGCAGTCAGCAAGAAGACCTTCCCGACGGTCAACCCTACC
ACCGGGGAGGTCATCGGGCACGTGGCTGAAGGTGACCGGGCTGATGTGGATCGGGCCGTG
AAAGCAGCCCGGGAAGCCTTCCGCCTGGGGTCCCCATGGCGCCGGATGGATGCCTCTGAG
CGGGGCCGGCTGCTGAACCTCCTGGCAGACCTAGTGGAGCGGGATCGAGTCTACTTGGCC
TCACTCGAGACCTTGGACAATGGGAAGCCTTTCCAAGAGTCTTACGCCTTGGACTTGGAT
GAGGTCATCAAGGTGTATCGGTACTTTGCTGGCTGGGCTGACAAGTGGCATGGCAAGACC
ATCCCCATGCATGGCCAGCATTTCTGCTTCACCCGGCATGAGCCCGTTGGTGTCTGTGGC
CAGATCATCCCGTGGAACTTCCCCTTGGTCATGCAGGGTTGGAAACTTGCCCCGGCACTC
GCCACAGGCAACACTGTGGTTATGAAGGTGGCAGAGCAGACCCCCCTCTCTGCCCTGTAT
TTGGCCTCCCTCATCAAGGAGGCAGGCTTTCCCCCTGGGGTGGTGAACATCATCACGGGG
TATGGCCCAACAGCAGGTGCGGCCATCGCCCAGCACATGGATGTTGACAAAGTTGCCTTC
ACCGGTTCCACCGAGGTGGGCCACCTGATCCAGAAAGCAGCTGGCGATTCCAACCTCAAG
AGAGTCACCCTGGAGCTGGGTGGTAAGAGCCCCAGCATCGTGCTGGCCGATGCTGACATG
GAGCATGCCGTGGAGCAGTGCCACGAAGCCCTGTTCTTCAACATGGGCCAGTGCTGCTGT
GCTGGCTCCCGGACCTTCGTGGAAGAATCCATCTACAATGAGTTTCTCGAGAGAACCGTG
GAGAAAGCAAAGCAGAGGAAAGTGGGGAACCCCTTTGAGCTGGACACCCAGCAGGGGCCT
CAGGTGGACAAGGAGCAGTTTGAACGAGTCCTAGGCTACATCCAGCTTGGCCAGAAGGAG
GGCGCAAAACTCCTCTGTGGCGGAGAGCGTTTCGGGGAGCGTGGTTTCTTCATCAAGCCT
ACTGTCTTTGGTGGCGTGCAGGATGACATGAGAATTGCCAAAGAGGAGATCTTTGGGCCT
GTGCAGCCCCTGTTCAAGTTCAAGAAGATTGAGGAGGTGGTTGAGAGGGCCAACAACACC
AGGTATGGCCTGGCTGCGGCTGTGTTCACCCGGGATCTGGACAAGGCCATGTACTTCACC
CAGGCACTCCAGGCCGGGACCGTGTGGGTAAACACCTACAACATCGTCACCTGCCACACG
CCATTTGGAGGGTTTAAGGAATCTGGAAACGGGAGGGAGCTGGGTGAGGATGGGCTTAAG
GCCTACACAGAGGTAAAGACGGTCACCATCAAGGTTCCTCAGAAGAACTCGTAA

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M63967

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_20_Locus:
9p11.1

# Metabolic_Enzyme_20_SNPs:
rs2228093; rs4878199; rs2073478; rs2073477; rs2228094; rs3043; rs6476701; rs10758494; rs10758495; rs7859877; rs4646772; rs4646774; rs4878802; rs10738997; rs11555705; rs4646773; rs41278335; rs11555706; rs10973781; rs10973782; rs12343271; rs41278337; rs10118683; rs10758496; rs10814687; rs10973774; rs10973779; rs10973783; rs10973785; rs10973786; rs10973787; rs10973789; rs10973792; rs11361; rs11790480; rs11791018; rs11791622; rs12001093; rs12336048; rs12352007; rs12378762; rs13285234; rs13290293; rs1555480; rs1923423; rs1923424; rs2038589; rs34183602; rs35950473; rs4142260; rs4242647; rs4878203; rs4878800; rs4878801; rs4878804; rs4878805; rs4878806; rs4878807; rs4878808; rs4878809; rs4878811; rs6476703; rs7021469; rs7031628; rs7045542; rs7046137; rs7853954; rs7865905; rs7866277; rs7867383; rs911757; rs911758

# Metabolic_Enzyme_20_General_References:
2061311; 8244338

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5530

# Metabolic_Enzyme_21_Name:
Aldehyde dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_21_Synonyms:
ALDH class 2; ALDHI; ALDH-E2

# Metabolic_Enzyme_21_Gene_Name:
ALDH2

# Metabolic_Enzyme_21_Protein_Sequence:
>Aldehyde dehydrogenase, mitochondrial precursor
MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

# Metabolic_Enzyme_21_Number_of_Residues:
517

# Metabolic_Enzyme_21_Molecular_Weight:
56382

# Metabolic_Enzyme_21_Theoretical_pI:
7.05

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_21_Specific_Function:
An aldehyde + NAD(+) + H(2)O = an acid + NADH

# Metabolic_Enzyme_21_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_21_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_21_Signals:
1-24

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_21_GenBank_ID_Protein:
28606

# Metabolic_Enzyme_21_SwissProt_ID:
ALDH2_HUMAN (P05091)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ALDH2

# Metabolic_Enzyme_21_Geneatlas_id:
ALDH2

# Metabolic_Enzyme_21_hgnc_id:
HGNC:404

# Metabolic_Enzyme_21_PDB_ID:
1OF7

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_21_Gene_Sequence:
>1551 bp
ATGTTGCGCGCTGCCGCCGCTCGGGCCCCGCCTGGCCGCCGCCTCTTGTCAGCCGCCGCC
ACCCAGGCCGTGCCTGCCCCCAACCAGCAGCCCGAGGTCTTCTGCAACCAGATTTTCATA
AACAATGAATGGCACGATGCCGTCAGCAGGAAAACATTCCCCACCGTCAATCCGTCCACT
GGAGAGGTCATCTGTCAGGTAGCTGAAGGGGACAAGGAAGATGTGGACAAGGCACGTGAA
GGCCGCCCGGGCGCCTTCCAGCTGGGCTCACCTTGGCGCCGCATGGACGCATCACACAGC
GGCCGGCTGCTGAACCGCCTGGCCGATCTGATCGAGCGGGACCGGACCTACCTGGCGGCC
TTGGAGACCCTGGACAATGGCAAGCCCTATGTCATCTCCTACCTGGTGGATTTGGACATG
GTCCTCAAATGTCTCCGGTATTATGCCGGCTGGGCTGATAAGTACCACGGGAAAACCATC
CCCATTGACGGAGACTTCTTCAGCTACACACGCCATGAACCTGTGGGGGTGTGCGGGCAG
ATCATTCCGTGGAATTTCCCGCTCCTGATGCAAGCATGGAAGCTGGGCCCAGCCTTGGCA
ACTGGAAACGTGGTTGTGATGAAGGTAGCTGAGCAGACACCCCTCACCGCCCTCTATGTG
GCCAACCTGATCAAGGAGGCTGGCTTTCCCCCTGGTGTGGTCAACATTGTGCCTGGATTT
GGCCCCACGGCTGGGGCCGCCATTGCCTCCCATGAGGATGTGGACAAAGTGGCATTCACA
GGCTCCACTGAGATTGGCCGCGTAATCCAGGTTGCTGCTGGGAGCAGCAACCTCAAGAGA
GTGACCTTGGAGCTGGGGGGGAAGAGCCCCAACATCATCATGTCAGATGCCGATATGGAT
TGGGCCGTGGAACAGGCCCACTTCGCCCTGTTCTTCAACCAGGGCCAGTGCTGCTGTGCC
GGCTCCCGGACCTTCGTGCAGGAGGACATCTATGATGAGTTTGTGGTGCGGAGCGTTGCC
CGGGCCAAGTCTCGGGTGGTCGGGAACCCCTTTGATAGCAAGACCGAGCAGGGGCCGCAG
GTGGATGAAACTCAGTTTAAGAAGATCCTCGGCTACATCAACACGGGGAAGCAAGAGGGG
GCGAAGCTGCTGTGTGGTGGGGGCATTGCTGCTGACCGTGGTTACTTCATCCAGCCCACT
GTGTTTGGAGATGTGCAGGATGGCATGACCATCGCCAAGGAGGAGATCTTCGGGCCAGTG
ATGCAGATCCTGAAGTTCAAGACCATAGAGGAGGTTGTTGGGAGAGCCAACAATTCCACG
TACGGGCTGGCCGCAGCTGTCTTCACAAAGGATTTGGACAAGGCCAATTACCTGTCCCAG
GCCCTCCAGGCGGGCACTGTGTGGGTCAACTGCTATGATGTGTTTGGAGCCCAGTCACCC
TTTGGTGGCTACAAGATGTCGGGGAGTGGCCGGGAGTTGGGCGAGTACGGGCTGCAGGCA
TACACTGAAGTGAAAACTGTCACAGTCAAAGTGCCTCAGAAGAACTCATAA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
X05409

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_21_Locus:
12q24.2

# Metabolic_Enzyme_21_SNPs:
rs671; rs1062136; rs6490301; rs886205; rs2238151; rs968529; rs7296651; rs441; rs4767939; rs10744777; rs4646778; rs4767944; rs10849970; rs2158029; rs4646776; rs7312055; rs7311852; rs2238152; rs4646777; rs2283354; rs10774637; rs4648328; rs10774638; rs11609628; rs11066028; rs4646779; rs16941669; rs440; rs7397491; rs11834780; rs16941667; rs4646775; rs11066029; rs35154896; rs11066024; rs2106696; rs11613231; rs2158028; rs4767035; rs13306166; rs34083959; rs7136890; rs13306164; rs1064933; rs34477327; rs34884061; rs28633753; rs11442381; rs11615695; rs11066023; rs35511855; rs35781311; rs13306163; rs7397456; rs35050853; rs35642129; rs12312867; rs12829533; rs11407827; rs34480430; rs12314397; rs35264878; rs12813835; rs12322000; rs34896918; rs35650885; rs7970477; rs11066025; rs13306167; rs11066027; rs12301347; rs11614684; rs35700215; rs35746295; rs34587287; rs13306165; rs35786282; rs11066022; rs7397469; rs11066030; rs10450717; rs35693865; rs11503169; rs35546929; rs33973376; rs34497874; rs12830829; rs35061167; rs11609093; rs36073646; rs34108639; rs12824249; rs11610258; rs35147079; rs11613713; rs11066026; rs7486832; rs12099590; rs3832868; rs34300515; rs35212101; rs7398472; rs35239056; rs35752199; rs5800933; rs11613351; rs5023470; rs34587619; rs4646781; rs4646780; rs11304348; rs12305979; rs4646782; rs10849969; rs10849971; rs11066032; rs14630; rs2339839; rs2339840; rs7133964; rs737280; rs739580; rs7974339; rs7978737; rs9971942

# Metabolic_Enzyme_21_General_References:
3582651; 3562250; 2838413; 4065146; 2987944; 4015823; 3610592; 3653404; 6582480; 8561277; 10631996

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5531

# Metabolic_Enzyme_22_Name:
Fatty aldehyde dehydrogenase

# Metabolic_Enzyme_22_Synonyms:
Aldehyde dehydrogenase, microsomal; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10

# Metabolic_Enzyme_22_Gene_Name:
ALDH3A2

# Metabolic_Enzyme_22_Protein_Sequence:
>Fatty aldehyde dehydrogenase
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY

# Metabolic_Enzyme_22_Number_of_Residues:
485

# Metabolic_Enzyme_22_Molecular_Weight:
54849

# Metabolic_Enzyme_22_Theoretical_pI:
7.99

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_22_Specific_Function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

# Metabolic_Enzyme_22_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00053  Ascorbate and aldarate metabolism;
 map00071  Fatty acid metabolism;
 map00120  Bile acid biosynthesis;
 map00280  Valine, leucine and isoleucine degradation;
 map00310  Lysine degradation;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism;
 map00631  1,2-Dichloroethane degradation;
 map00640  Propanoate metabolism;
 map00650  Butanoate metabolism;
 map00903  Limonene and pinene degradation

# Metabolic_Enzyme_22_Reaction:
an aldehyde + NAD+ + H2O = an acid + NADH + H+

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
464-480

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 1.2.1.3

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1082036

# Metabolic_Enzyme_22_SwissProt_ID:
AL3A2_HUMAN (P51648)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ALDH3A2

# Metabolic_Enzyme_22_Geneatlas_id:
ALDH3A2

# Metabolic_Enzyme_22_hgnc_id:
HGNC:403

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein; cytoplasmic side

# Metabolic_Enzyme_22_Gene_Sequence:
>1458 bp
ATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTG
CGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGAT
ATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAA
GTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACT
GCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAG
CCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAG
CCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGT
GAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTAT
ATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCAC
ATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCAT
CTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGT
GACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACC
TGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAG
ATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAA
AGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATA
GCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGAT
GTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTG
CCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCT
CTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGT
GGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGA
GGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCT
CATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATAT
CCTCCCAACAGCCAGTCAAAGGTGGATTGGGGGAAATTTTTTCTCTTGAAACGGTTCAAC
AAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTC
AAGGCAGAATATTACTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
L47162

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_22_Locus:
17p11.2

# Metabolic_Enzyme_22_SNPs:
rs7216; rs7503517; rs7215; rs16420; rs11204408; rs3786038; rs962801; rs2072333; rs1034897; rs2072331; rs2108971; rs1004490; rs1004491; rs4244600; rs962800; rs8069576; rs4925036; rs2072332; rs16960280; rs4646797; rs8069478; rs2386145; rs1800869; rs11204407; rs4646798; rs4646794; rs4925038; rs4646800; rs4925037; rs4646795; rs4646804; rs4646802; rs8073767; rs12937946; rs9910300; rs4646801; rs9901895; rs1034896; rs3760489; rs4621031; rs3888642; rs1057405; rs11548343; rs12947169; rs34160909; rs35364675; rs7209322; rs35495378; rs12947168; rs12708; rs4646805; rs7215552; rs35965955; rs2386146; rs35716578; rs34082599; rs4646799; rs4646796; rs3034928; rs1800870; rs35581449; rs5819686; rs34567842; rs34350257; rs34642385; rs4646793; rs11652177; rs4646907; rs34471504; rs8073053; rs2386147; rs6146012; rs34945824; rs36031953; rs34327718; rs35797108; rs34664206; rs4646803; rs35265843; rs36025724; rs35053333; rs3841513; rs34368630; rs4646806; rs35604266; rs16960266; rs28375263; rs11868363; rs11871420; rs11871642; rs12937179; rs1804608; rs2386144; rs34399035; rs34416664; rs35526408; rs4646807; rs4925026; rs8065688; rs8074204; rs8074500

# Metabolic_Enzyme_22_General_References:
8528251; 9027499; 9070922; 9254849; 9829906

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5526

# Metabolic_Enzyme_23_Name:
4-trimethylaminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_23_Synonyms:
TMABADH; Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Gamma-aminobutyraldehyde dehydrogenase; R- aminobutyraldehyde dehydrogenase

# Metabolic_Enzyme_23_Gene_Name:
ALDH9A1

# Metabolic_Enzyme_23_Protein_Sequence:
>4trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF

# Metabolic_Enzyme_23_Number_of_Residues:
494

# Metabolic_Enzyme_23_Molecular_Weight:
53802

# Metabolic_Enzyme_23_Theoretical_pI:
5.61

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_23_Specific_Function:
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

# Metabolic_Enzyme_23_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_23_Reaction:
4-trimethylammoniobutanal + NAD+ = 4-trimethylammoniobutanoate + NADH + H+

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00171:Aldedh

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 1.2.1.47;EC 1.2.1.3;EC

# Metabolic_Enzyme_23_GenBank_ID_Protein:
1049219

# Metabolic_Enzyme_23_SwissProt_ID:
AL9A1_HUMAN (P49189)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ALDH9A1

# Metabolic_Enzyme_23_Geneatlas_id:
ALDH9A1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:412

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_23_Gene_Sequence:
>1482 bp
ATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGCGGGGCCGCTGGA
GCCGGCGGACGCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACCGGCCGAGTGATAGCT
ACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAAAATGCAAAGGCTGCT
TTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATCCTTTTGGAGGCTGCC
AGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGCATCAACAATGGCAAG
TCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGCCTGGAGTATTATGCG
GGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGTGGATCGTTTGGTTAT
ACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGGAACTACCCCTTTCAG
ATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCCATGGTCTTTAAACCT
TCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTACAGTGAGGCTGGTGTA
CCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGCCAGTTTCTGTGTCAG
CATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACTGGCATGAAGATCATG
GAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGAGGCAAATCTCCACTC
ATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCGCTGATGGCCAACTTC
CTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTGCAGAAAGAAATTCTT
GATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAAATTGGAGATCCCCTT
CTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTGGAGCGAGTCCTTGGG
TTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGTGGAGATATATATGTA
CCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGTGTATTAACTAATTGC
AGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTTATGTCCATTTTATCA
TTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACTTTTGGACTAGCAGCT
GGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGG
ACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAG
AAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAG
ACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
U34252

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1q23.1

# Metabolic_Enzyme_23_SNPs:
rs1065756; rs11808728; rs1143659; rs11506; rs12670; rs12408101; rs1913844; rs2882006; rs10753688; rs4646891; rs4646889; rs7516126; rs12565874; rs3820362; rs10800129; rs10800128; rs7534437; rs12072634; rs4656457; rs1337442; rs2348728; rs4578194; rs12080699; rs7541817; rs10918239; rs2348727; rs3738192; rs6683969; rs12065621; rs2348734; rs16849230; rs6426930; rs12083232; rs7513998; rs12122497; rs7555787; rs4646886; rs10800127; rs10918252; rs2348729; rs4646883; rs7518869; rs10800133; rs2176151; rs4646882; rs1538115; rs10800131; rs4646897; rs6690818; rs2050619; rs10753689; rs7546084; rs12076579; rs17482717; rs4657463; rs10918235; rs11587760; rs4274037; rs12567331; rs4557947; rs1337443; rs10800130; rs10800132; rs4646895; rs16849238; rs17450889; rs12033254; rs12069198; rs6657651; rs10918245; rs3845537; rs10918237; rs11807857; rs11807866; rs884121; rs4657462; rs10918236; rs7543204; rs2184918; rs12070650; rs17417191; rs9970857; rs6662419; rs7367737; rs10918242; rs10918241; rs7546322; rs4646888; rs16849374; rs12409168; rs12037790; rs10918247; rs7537071; rs12084748; rs10918238; rs7368130; rs2348730; rs10918244; rs4233407; rs12123278; rs4646892; rs4657466; rs4576644; rs6683651; rs6667075; rs12021795; rs6683665; rs12081464; rs7546215; rs7519162; rs10918240; rs6667088; rs6669697; rs12081903; rs4646885; rs7542184; rs16849479; rs4646887; rs12072664; rs10753687; rs4646896; rs10157944; rs6668102; rs3753893; rs4657468; rs3753892; rs7553712; rs7511691; rs7554409; rs7544840; rs6426928; rs6667681; rs4646881; rs1415503; rs11555775; rs9164; rs4646902; rs6667510; rs11555774; rs4307543; rs11436915; rs34948330; rs12139219; rs34495301; rs10918248; rs1890080; rs35894201; rs4646884; rs28759374; rs12137604; rs28589393; rs34662022; rs12354157; rs10918246; rs35087657; rs34105906; rs35913333; rs34664103; rs12083492; rs2271658; rs34872122; rs7512816; rs4646893; rs7527514; rs12566251; rs1970286; rs3831954; rs2348731; rs10918249; rs35178491; rs36027739; rs35864611; rs17416948; rs4646894; rs11583089; rs12742656; rs12754903; rs12742657; rs41267568; rs4646890; rs12084651; rs4646900; rs34304173; rs13376536; rs12727801; rs41326750; rs28439296; rs12134617; rs12036561; rs35531113; rs3845536; rs36011778; rs12090132; rs7525102; rs10918250; rs3738191; rs12239517; rs4646898; rs34072474; rs34945812; rs10918251; rs1890079; rs35439339; rs36150573; rs1577847; rs12728137; rs34846458; rs4646901; rs36110991; rs12083091; rs34894576; rs6426927; rs11458950; rs1856143; rs35757606; rs41267564; rs41267566; rs35742388; rs10494446; rs10494447; rs10800123; rs10800125; rs10800126; rs10800135; rs10800136; rs10918228; rs10918229; rs10918231; rs10918254; rs10918255; rs10918256; rs11579160; rs11800476; rs11810856; rs12027066; rs12028588; rs12043815; rs12044709; rs12060366; rs12143472; rs12748251; rs1547725; rs16848876; rs16848958; rs16849041; rs16849616; rs1878074; rs1878075; rs2090281; rs2297762; rs2297763; rs2297764; rs2297765; rs3753894; rs3795540; rs4147602; rs4147604; rs4147605; rs4147610; rs4147611; rs4341347; rs7527279; rs7549511; rs7551594; rs8133; rs9333483; rs9333487; rs9919190

# Metabolic_Enzyme_23_General_References:
8786138; 10702312; 8645224; 8269919; 2925663

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5324

# Metabolic_Enzyme_24_Name:
Serum paraoxonase/arylesterase 2

# Metabolic_Enzyme_24_Synonyms:
PON 2; Serum aryldialkylphosphatase 2; A-esterase 2; Aromatic esterase 2

# Metabolic_Enzyme_24_Gene_Name:
PON2

# Metabolic_Enzyme_24_Protein_Sequence:
>Serum paraoxonase/arylesterase 2
MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
GLAFFSVGLK
FPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF
IDNDDTVYLFVVNHPEFKNTV
EIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFY
ATNDHYFSDPFLKYLETYLNLHWANVVYYSPN
EVKVVAEGFDSANGINISPDDKYIYVA
DILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIW
VGCHPNGQKLFVYDPN
NPPSSEVLRIQNILCEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRAL
YCEL

# Metabolic_Enzyme_24_Number_of_Residues:
354

# Metabolic_Enzyme_24_Molecular_Weight:
39398

# Metabolic_Enzyme_24_Theoretical_pI:
5.21

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis

# Metabolic_Enzyme_24_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation

# Metabolic_Enzyme_24_Reaction:
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_24_Signals:
1-

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1333632

# Metabolic_Enzyme_24_SwissProt_ID:
PON2_HUMAN (Q15165)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PON2

# Metabolic_Enzyme_24_Geneatlas_id:
PON2

# Metabolic_Enzyme_24_hgnc_id:
HGNC:9205

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Membrane; peripheral membrane protein

# Metabolic_Enzyme_24_Gene_Sequence:
>1065 bp

ATGGGGGCCTGGGTGGGCTGTGGGCTTGCTGGGGATCGCGCTGGCTTCCTGGGCGAGAG
GCTTCTGGCAC
TCAGAAATCGACTTAAAGCCTCCAGAGAAGTAGAATCTGTAGACCTTC
CACACTGCCACCTGATTAAAGG
AATTGAAGCTGGCTCTGAAGATATTGACATACTTCCC
AATGGTCTGGCTTTTTTTAGTGTGGGTCTAAAA
TTCCCAGGACTCCACAGCTTTGCACC
AGATAAGCCTGGAGGAATACTAATGATGGATCTAAAAGAAGAAA
AACCAAGGGCACGGG
AATTAAGAATCAGTCGTGGGTTTGATTTGGCCTCATTCAATCCACATGGCATCAG
CACT
TTCATAGACAACGATGACACAGTTTATCTCTTTGTTGTAAACCACCCAGAATTCAAGAAT
ACAGTG
GAAATTTTTAAATTTGAAGAAGCAGAAAATTCTCTGTTGCATCTGAAAACAGT
CAAACATGAGCTTCTTC
CAAGTGTGAATGACATCACAGCTGTTGGACCGGCACATTTCT
ATGCCACAAATGACCACTACTTCTCTGA
TCCTTTCTTAAAGTATTTAGGAACATACTTG
AACTTACACTGGGCAAATGTTGTTTACTACAGTCCAAAT
GAAGTTAAAGTGGTAGCAGA
AGGATTTGATTCAGCAAATGGGATCAATATTTCACCTGATGATAAGTATA
TCTATGTTG
CTGACATATTGGCTCATGAAATTCATGTTTTGGAAAAACACACTAATATGAATTTAACTC
A
GTTGAAGGTACTTGAGCTGGATACACTGGTGGATAATTTATCTATTGATCCTTCCTCG
GGGGACATCTGG
GTAGGCTGTCATCCTAATGGCCAGAAGCTCTTCGTGTATGACCCGAA
CAATCCTCCCTCGTCAGAGGTTC
TCCGCATCCAGAACATTCTATGTGAGAAGCCTACAG
TGACTACAGTTTATGCCAACAATGGGTCTGTTCT
CCAAGGAAGTTCTGTAGCCTCAGTG
TATGATGGGAAGCTGCTCATAGGCACTTTATACCACAGAGCCTTG
TATTGTGAACTCTA
A

# Metabolic_Enzyme_24_GenBank_ID_Gene:
L48513

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_24_Locus:
7q21.3

# Metabolic_Enzyme_24_SNPs:
rs7493; rs12026; rs3918; rs17876172; rs17876183; rs2299264; rs2237585; rs987539; rs730365; rs2286232; rs2068604; rs2375005; rs2299263; rs9640633; rs6968305; rs740265; rs4729189; rs2057965; rs6961624; rs12704794; rs6973380; rs10487133; rs7801803; rs1639; rs3779492; rs2299267; rs17166875; rs17876116; rs2158806; rs11770901; rs12669182; rs17166879; rs3831552; rs10261470; rs17774346; rs11982486; rs7803148; rs2299266; rs17876129; rs2374993; rs10249263; rs2299265; rs10259688; rs10273532; rs6970627; rs11979545; rs7802018; rs730364; rs3735586; rs6961773; rs3216252; rs11981433; rs13438526; rs11976060; rs2286233; rs17876083; rs9641164; rs7785039; rs1034809; rs12155103; rs12704795; rs12534274; rs17876144; rs17876080; rs17876190; rs13245169; rs17876092; rs17876061; rs17876154; rs17876125; rs17876143; rs17876195; rs2040993; rs17876198; rs17876078; rs17876196; rs17876191; rs17876106; rs17876100; rs17876062; rs17876141; rs17876132; rs11323880; rs17876148; rs17876124; rs17879936; rs17876150; rs17876187; rs17876073; rs17876090; rs17876133; rs17876094; rs17876065; rs17876197; rs17876123; rs2237586; rs2057964; rs17876082; rs17876186; rs17876158; rs17876162; rs17876202; rs17876093; rs17876188; rs7794650; rs17876193; rs17876054; rs5885909; rs5885910; rs17876189; rs17876201; rs7785846; rs7785705; rs13306702; rs17166868; rs7786401; rs17876207; rs17876182; rs12704796; rs17876174; rs17876205; rs17876177; rs13306699; rs11545942; rs17876152; rs13306701; rs11545945; rs17876170; rs28376783; rs35210485; rs34396360; rs34242940; rs35432158; rs6964976; rs17876136; rs34903539; rs10694604; rs17876164; rs6968413; rs17876107; rs6465465; rs17876138; rs17876068; rs17876063; rs17876096; rs3216253; rs10264677; rs17876149; rs34766260; rs17876153; rs35269697; rs17876200; rs17876117; rs6978409; rs17876052; rs17876051; rs11413689; rs17876071; rs17876126; rs11451805; rs17717505; rs17876055; rs3046691; rs35930446; rs2040994; rs3831551; rs35686517; rs34077651; rs35310147; rs17876203; rs35234425; rs13306700; rs35284743; rs17876147; rs17876167; rs17876128; rs17876085; rs17876192; rs17876184; rs17876114; rs34561655; rs17876102; rs17876145; rs17876113; rs1034808; rs13223805; rs36033819; rs17876120; rs17876137; rs28530741; rs17876050; rs11767136; rs17876199; rs17876069; rs17876204; rs35852389; rs11283397; rs2068515; rs17876058; rs17876103; rs34057625; rs17876077; rs17883881; rs10257156; rs17876168; rs10224756; rs17876108; rs6946563; rs13242985; rs36229209; rs17166881; rs17876181; rs35216848; rs17876206; rs7805636; rs10674344; rs36229207; rs17169554; rs17876180; rs13243633; rs13242987; rs34196943; rs13243101; rs17876179; rs34718179; rs10686867; rs11974483; rs1006522; rs10260134; rs10953147; rs11764079; rs11767787; rs11770903; rs11977702; rs11981299; rs12535571; rs13226149; rs13233527; rs17879277; rs17879517; rs2072199; rs2072200; rs34305047; rs3757707; rs43037; rs43038; rs43039; rs43040; rs43041; rs43042; rs43044; rs6946850; rs6973282; rs6978425; rs7811616

# Metabolic_Enzyme_24_General_References:
8661009; 9714608; 12853948; 11579088; 9329371; 9443862

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5829

# Metabolic_Enzyme_25_Name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

# Metabolic_Enzyme_25_Synonyms:
Phosphatidylinositol-glycan biosynthesis class L protein; PIG-L

# Metabolic_Enzyme_25_Gene_Name:
PIGL

# Metabolic_Enzyme_25_Protein_Sequence:
>Nacetylglucosaminylphosphatidylinositol deNacetylase
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPT
VLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLGIPLSSVMIIDNRDFPDDPGM
QWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVL
TLQSVNVLRKYISLLDLPLSLLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIF
SRYMRINSLSFL

# Metabolic_Enzyme_25_Number_of_Residues:
252

# Metabolic_Enzyme_25_Molecular_Weight:
28532

# Metabolic_Enzyme_25_Theoretical_pI:
8.23

# Metabolic_Enzyme_25_GO_Classification:
Not Available

# Metabolic_Enzyme_25_General_Function:
Not Available

# Metabolic_Enzyme_25_Specific_Function:
Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol

# Metabolic_Enzyme_25_Pathway:
Not Available

# Metabolic_Enzyme_25_Reaction:
6-(N-acetyl-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF02585:PIG-L

# Metabolic_Enzyme_25_Signals:
1-17

# Metabolic_Enzyme_25_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 3.5.1.89

# Metabolic_Enzyme_25_GenBank_ID_Protein:
4239986

# Metabolic_Enzyme_25_SwissProt_ID:
PIGL_HUMAN (Q9Y2B2)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PIGL

# Metabolic_Enzyme_25_Geneatlas_id:
PIGL

# Metabolic_Enzyme_25_hgnc_id:
HGNC:8966

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein

# Metabolic_Enzyme_25_Gene_Sequence:
>759 bp
ATGGAAGCAATGTGGCTCCTGTGTGTGGCGTTGGCGGTCTTGGCATGGGGCTTCCTCTGG
GTTTGGGACTCCTCAGAACGAATGAAGAGTCGGGAGCAGGGAGGACGGCTGGGAGCCGAA
AGCCGGACCCTGCTGGTCATAGCGCACCCTGACGATGAAGCCATGTTTTTTGCTCCCACA
GTGCTAGGCTTGGCCCGCCTAAGGCACTGGGTGTACCTGCTTTGCTTCTCTGCAGGAAAT
TACTACAATCAAGGAGAGACTCGTAAGAAAGAACTTTTGCAGAGCTGTGATGTTTTGGGG
ATTCCACTCTCCAGTGTAATGATTATTGACAACAGGGATTTCCCAGATGACCCAGGCATG
CAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATC
AATCTGGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTG
TATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAAGTTACCTAAAGGGTGCTCTGTGCTC
ACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCT
CTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAG
AAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTC
TCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AB017165

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_25_Locus:
17p12-p11.2

# Metabolic_Enzyme_25_SNPs:
rs15739; rs2302314; rs2014604; rs8077885; rs4792731; rs178785; rs10852834; rs2109262; rs4792728; rs4792730; rs178788; rs3785626; rs7210224; rs3112513; rs7219687; rs11868284; rs7210990; rs11650427; rs1029809; rs178791; rs3112511; rs4791665; rs11078338; rs1005380; rs1018364; rs4470185; rs7219038; rs2074995; rs6502499; rs9909022; rs9944524; rs11651578; rs3095171; rs178790; rs9914734; rs178787; rs17779879; rs9893005; rs2005835; rs7224367; rs178794; rs3785625; rs7215071; rs3112512; rs4791664; rs8069679; rs9910148; rs7225920; rs178796; rs9797124; rs12948905; rs3785622; rs2013857; rs9890539; rs4792726; rs7218342; rs9903871; rs11655325; rs12150285; rs2324306; rs11078337; rs178795; rs7225926; rs4588022; rs7217230; rs3785620; rs12945959; rs2324307; rs9901194; rs7217418; rs11871194; rs178792; rs9908081; rs6502498; rs4792729; rs12936233; rs12948244; rs11656811; rs12946619; rs10221252; rs7225649; rs9896275; rs3112510; rs7212650; rs7212903; rs7211819; rs11650956; rs3785624; rs8070979; rs12938397; rs8065649; rs11652044; rs9747114; rs3785623; rs12938394; rs11654658; rs7223428; rs9303135; rs8074727; rs764984; rs7211754; rs3785621; rs178793; rs1963811; rs7215673; rs12945855; rs35803470; rs12946511; rs35172054; rs35568368; rs34416574; rs3034004; rs35565381; rs28566930; rs12952668; rs34456796; rs12103479; rs8076400; rs34777606; rs9897061; rs3112514; rs36070251; rs34657944; rs12939090; rs34414046; rs11299226; rs35676198; rs34243048; rs9909941; rs7216781; rs34629340; rs34940044; rs12937203; rs34698708; rs11653500; rs35030168; rs34187120; rs34748399; rs10522327; rs8076724; rs3033989; rs5819562; rs36009074; rs8078533; rs12951660; rs12600944; rs8077876; rs35572629; rs11078336; rs12939543; rs11298241; rs35973689; rs12937205; rs8073259; rs11422750; rs36103182; rs12950571; rs4352085; rs34325866; rs11460317; rs7214301; rs12936529; rs11364104; rs35852993; rs34184162; rs9897070; rs9916220; rs7209811; rs34784588; rs35271065; rs12939078; rs9789072; rs34426136; rs35781493; rs8067404; rs35883694; rs11429532; rs7215583; rs28575753; rs34927087; rs36044246; rs5819561; rs35814080; rs2109258; rs35787320; rs34707095; rs12937182; rs34470162; rs11382153; rs7223807; rs11078335; rs35319034; rs7219665; rs7503498; rs3112515; rs178786; rs28516015; rs35895483; rs35667387; rs12938458; rs12939072; rs35703186; rs8066726; rs28622079; rs33911414; rs11382150; rs7219795; rs12602140; rs34110087; rs34331598; rs8067000; rs12938878; rs34479966; rs12946929; rs5015580; rs12952882; rs11653650; rs5819563; rs34962159; rs8068254; rs33994669; rs11650940; rs7219810; rs35909942; rs35730395; rs34743037; rs35458445; rs34694974; rs1985977; rs11435438; rs7219980; rs35821817; rs35901849; rs178789; rs8075636; rs8075655; rs10578326; rs35285920; rs12935928; rs12103680; rs34952168; rs34518917; rs12150564; rs35504589; rs34566690; rs34204371; rs35578509; rs34827519; rs11415569; rs10048156; rs35594899; rs11379081; rs7211515; rs12452870; rs34289173; rs36030857; rs8071289; rs35328073; rs10578327; rs28551630; rs9898510; rs9889720; rs34639894; rs11350245; rs11870456; rs4791666; rs2324305; rs12951442; rs12103478; rs12938858; rs9783845; rs2533007; rs34133338; rs12952432; rs9789071; rs34019457; rs35751075; rs34851411; rs9900232; rs12951388; rs28577957; rs34410992; rs7219335; rs11651955; rs11867824; rs12945877; rs1476810; rs178797; rs178798; rs2272775; rs3095169; rs34475723; rs7210068; rs7212874; rs9890867

# Metabolic_Enzyme_25_General_References:
10085243

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5323

# Metabolic_Enzyme_26_Name:
Serum paraoxonase/arylesterase 1

# Metabolic_Enzyme_26_Synonyms:
PON 1; Serum aryldialkylphosphatase 1; A-esterase 1; Aromatic esterase 1; K-45

# Metabolic_Enzyme_26_Gene_Name:
PON1

# Metabolic_Enzyme_26_Protein_Sequence:
>Serum paraoxonase/arylesterase 1
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDMEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL

# Metabolic_Enzyme_26_Number_of_Residues:
355

# Metabolic_Enzyme_26_Molecular_Weight:
39750

# Metabolic_Enzyme_26_Theoretical_pI:
4.89

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  carboxylic ester hydrolase activity
Function:  arylesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. May mediate an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation

# Metabolic_Enzyme_26_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation

# Metabolic_Enzyme_26_Reaction:
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01731:Arylesterase

# Metabolic_Enzyme_26_Signals:
1-

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 3.1.1.2;EC 3.1.8.1

# Metabolic_Enzyme_26_GenBank_ID_Protein:
190192

# Metabolic_Enzyme_26_SwissProt_ID:
PON1_HUMAN (P27169)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
PON1

# Metabolic_Enzyme_26_Geneatlas_id:
PON1

# Metabolic_Enzyme_26_hgnc_id:
HGNC:9204

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_26_Gene_Sequence:
>1068 bp
ATGGCGAAGCTGATTGCGCTCACCCTCTTGGGGATGGGACTGGCACTCTTCAGGAACCAC
CAGTCTTCTTACCAAACACGACTTAATGCTCTCCGAGAGGTACAACCCGTAGAACTTCCT
AACTGTAATTTAGTTAAAGGAATCGAAACTGGCTCTGAAGACATGGAGATACTGCCTAAT
GGACTGGCTTTCATTAGCTCTGGATTAAAGTATCCTGGAATAAAGAGCTTCAACCCCAAC
AGTCCTGGAAAAATACTTCTGATGGACCTGAATGAAGAAGATCCAACAGTGTTGGAATTG
GGGATCACTGGAAGTAAATTTGATGTATCTTCATTTAACCCTCATGGGATTAGCACATTC
ACAGATGAAGATAATGCCATGTACCTCCTGGTGGTGAACCATCCAGATGCCAAGTCCACA
GTGGAGTTGTTTAAATTTCAAGAAGAAGAAAAATCGCTTTTGCATCTAAAAACCATCAGA
CATAAACTTCTGCCTAATTTGAATGATATTGTTGCTGTGGGACCTGAGCACTTTTATGGC
ACAAATGATCACTATTTTCTTGACCCCTACTTACAATCCTGGGAGATGTATTTGGGTTTA
GCGTGGTCGTATGTTGTCTACTATAGTCCAAGTGAAGTTCGAGTGGTGGCAGAAGGATTT
GATTTTGCTAATGGAATCAACATTTCACCCGATGGCAAGTATGTCTATATAGCTGAGTTG
CTGGCTCATAAGATTCATGTGTATGAAAAGCATGCTAATTGGACTTTAACTCCATTGAAG
TCCCTTGACTTTAATACCCTCGTGGATAACATATCTGTGGATCCTGAGACAGGAGACCTT
TGGGTTGGATGCCATCCCAATGGCATGAAAATCTTCTTCTATGACTCAGAGAATCCTCCT
GCATCAGAGGTGCTTCGAATCCAGAACATTCTAACAGAAGAACCTAAAGTGACACAGGTT
TATGCAGAAAATGGCACAGTGTTGCAAGGCAGTACAGTTGCCTCTGTGTACAAAGGGAAA
CTGCTGATTGGCACAGTGTTTCACAAAGCTCTTTACTGTGAGCTCTAA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
M63012

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_26_Locus:
7q21.3

# Metabolic_Enzyme_26_SNPs:
rs662; rs3917594; rs854560; rs854552; rs854551; rs3917575; rs3917577; rs3735590; rs3917576; rs854550; rs3917582; rs3917581; rs3917579; rs3917580; rs3917578; rs854568; rs854566; rs854569; rs2299260; rs854562; rs2237582; rs2299262; rs2272365; rs2237583; rs3917534; rs2299261; rs854563; rs854556; rs3917503; rs2049647; rs2269829; rs2049646; rs854557; rs854558; rs1157745; rs3917469; rs3917478; rs3917473; rs2074351; rs854561; rs2299256; rs3917498; rs3917521; rs3917549; rs3917537; rs3917524; rs2049649; rs2299255; rs854564; rs3917555; rs3917472; rs2057681; rs3917556; rs2301711; rs3917569; rs3917551; rs3917476; rs2074354; rs854565; rs3917477; rs2237584; rs3917514; rs3917529; rs3917539; rs3917538; rs3917550; rs3917490; rs3917475; rs3917502; rs3917548; rs3917559; rs854570; rs3917485; rs3917572; rs2299259; rs705378; rs854567; rs3917518; rs2237581; rs854553; rs3917558; rs2237580; rs3917541; rs3917564; rs2299257; rs854559; rs3917481; rs3917561; rs3917468; rs3917527; rs3917542; rs2158155; rs854555; rs3917532; rs17166810; rs3917492; rs3917500; rs3917471; rs3917533; rs3917596; rs3917590; rs3917493; rs3917467; rs7809060; rs3917525; rs3917547; rs3917491; rs2049648; rs3917562; rs10215036; rs3917566; rs3917563; rs4344018; rs3917528; rs3917510; rs3917509; rs3917536; rs17166812; rs3917557; rs11771594; rs3917568; rs3917570; rs3917506; rs3917483; rs3917517; rs3917545; rs3917571; rs3917589; rs3917488; rs3917515; rs854554; rs3917499; rs3917531; rs3917573; rs3917574; rs3917484; rs3917519; rs3917567; rs3917599; rs7792044; rs35409956; rs3917482; rs3917479; rs3917592; rs3917520; rs3917543; rs12669112; rs3917552; rs3917595; rs3917474; rs854549; rs705381; rs854571; rs854572; rs757158; rs705380; rs3917586; rs854573; rs705379; rs705382; rs3917464; rs3917463; rs3917583; rs3917601; rs3917466; rs3917584; rs13236941; rs13306698; rs35431117; rs13306695; rs3917600; rs3832528; rs3917512; rs3917494; rs5885907; rs33941136; rs34824830; rs4565398; rs3917597; rs11343146; rs3917535; rs3917591; rs10548570; rs3917546; rs3046663; rs3917513; rs3917598; rs1527723; rs3917553; rs10684571; rs41364245; rs10215712; rs28699500; rs34459620; rs10593904; rs3917522; rs4527804; rs3917511; rs28396660; rs5885906; rs36015658; rs36115777; rs3917523; rs3917508; rs3917516; rs5885904; rs3917489; rs3917486; rs3917505; rs3917504; rs34550136; rs35181743; rs3216251; rs3917588; rs5885905; rs1997230; rs34551559; rs3917544; rs3046658; rs35193664; rs3917530; rs35974860; rs28564906; rs3917540; rs4997889; rs2299258; rs3917487; rs35511949; rs3917507; rs35582633; rs3917560; rs3917495; rs34569909; rs34612855; rs13306696; rs11292716; rs3917593; rs35687400; rs10638749; rs34948808; rs10226158; rs11355011; rs10692484; rs34622204; rs2079088; rs34546681; rs3917470; rs34709624; rs7806699; rs3917496; rs3917501; rs3917565; rs3046669; rs3917526; rs17881027; rs6972570; rs3917465; rs3917587; rs35388471; rs34851166; rs3917585; rs10227092; rs10232531; rs11764692; rs11981667; rs12533898; rs13228784; rs17166759; rs17166761; rs17166818; rs17773605; rs4727312; rs8491; rs854542; rs854543; rs854544; rs854546; rs854547; rs854548; rs854574

# Metabolic_Enzyme_26_General_References:
1657140; 7916578; 8393742; 8393745; 8812495; 12853948; 8382160; 1718413; 1673382; 7638166; 8098250; 12783936

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5830

# Metabolic_Enzyme_27_Name:
Aspartoacylase-2

# Metabolic_Enzyme_27_Synonyms:
Aminoacylase-3; ACY-3; Acylase III; Hepatitis C virus core-binding protein 1; HCBP1

# Metabolic_Enzyme_27_Gene_Name:
ACY3

# Metabolic_Enzyme_27_Protein_Sequence:
>Aspartoacylase2
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
CRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTA
NMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELG
PQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLA
GTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK
FTFTVPAMPALTPAPSPAS

# Metabolic_Enzyme_27_Number_of_Residues:
319

# Metabolic_Enzyme_27_Molecular_Weight:
35241

# Metabolic_Enzyme_27_Theoretical_pI:
5.77

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_27_Specific_Function:
N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate

# Metabolic_Enzyme_27_Pathway:
map00252  Alanine and aspartate metabolism;
 map00340  Histidine metabolism

# Metabolic_Enzyme_27_Reaction:
N-acyl-L-aspartate + H2O = a carboxylate + L-aspartate

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF04952:AstE_AspA

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 3.5.1.15

# Metabolic_Enzyme_27_GenBank_ID_Protein:
21654856

# Metabolic_Enzyme_27_SwissProt_ID:
ACY3_HUMAN (Q96HD9)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
ACY3

# Metabolic_Enzyme_27_Geneatlas_id:
ACY3

# Metabolic_Enzyme_27_hgnc_id:
HGNC:24104

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_27_Gene_Sequence:
>960 bp
ATGTGCTCACTGCCTGTGCCCCGGGAGCCCCTGCGTCGCGTGGCTGTGACTGGGGGCACG
CATGGCAACGAGATGTCGGGCGTCTACCTGGCCCGGCACTGGCTGCATGCCCCCGCAGAG
CTGCAGAGAGCCAGCTTCTCCGCTGTGCCTGTGCTGGCCAACCCGGCAGCCACATCCGGC
TGCCGCCGCTACGTGGACCATGACCTCAACCGCACCTTCACCAGCAGCTTCCTCAATTCC
AGGCCCACCCCGGACGACCCATATGAGGTGACAAGAGCCCGAGAGCTGAACCAGCTGCTG
GGGCCCAAGGCCTCGGGCCAGGCCTTTGACTTTGTCCTTGACCTGCACAACACCACGGCC
AACATGGGCACCTGCTTAATCGCGAAGTCCTCCCACGAAGTCTTTGCCATGCACCTGTGC
CGCCATCTGCAGCTGCAGTACCCCGAGCTGTCCTGCCAGGTCTTCCTGTACCAGCGGTCT
GGGGAGGAGAGCTACAACCTGGACTCTGTGGCCAAAAATGGACTGGGTCTGGAGCTGGGC
CCCCAGCCACAGGGTGTGCTGCGGGCTGACATTTTCTCAAGGATGAGGACCCTGGTGGCC
ACAGTTCTGGACTTCATCGAACTCTTCAACCAGGGTACGGCCTTTCCTGCCTTTGAGATG
GAAGCCTATAGACCCGTGGGCGTCGTGGACTTCCCCCGCACCGAGGCCGGGCACCTGGCA
GGCACTGTGCATCCTCAGCTGCAGGACCGAGACTTCCAGCCACTGCAGCCTGGTGCTCCC
ATCTTCCAGATGTTCAGTGGGGAGGACCTGCTCTATGAGGGAGAGTCCACGGTGTACCCC
GTGTTCATTAACGAGGCTGCCTACTATGAGAAGGGCGTTGCCTTTGTCCAGACTGAGAAG
TTCACATTCACCGTGCCTGCCATGCCCGCGCTGACCCCTGCCCCGAGCCCAGCTTCCTAA


# Metabolic_Enzyme_27_GenBank_ID_Gene:
AY040761

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_27_Locus:
11q13.2

# Metabolic_Enzyme_27_SNPs:
rs2290959; rs948445; rs34796596; rs17148450; rs948446; rs2514037; rs2514035; rs3888976; rs2509717; rs2290960; rs1111928; rs2252577; rs2514036; rs2509715; rs2514039; rs2514042; rs2509714; rs2514032; rs2290958; rs2447587; rs2514033; rs948444; rs10736660; rs2514030; rs2252727; rs7127140; rs2509718; rs2509719; rs2514034; rs34667730; rs3029248; rs2361141; rs2361140; rs1871038; rs34786387; rs3029257; rs1871040; rs1871039; rs7108759; rs34976152; rs7108760; rs3029250; rs2514044; rs34146083; rs2509716; rs2514043; rs2361142; rs4520603; rs2514038; rs2361139; rs12281770; rs2447584; rs3029253; rs2514041; rs3029299; rs34783536; rs2250568; rs2361143; rs2447582; rs34359416; rs35110105; rs2447586; rs34892473; rs2514031; rs34790058; rs35512546; rs7108422; rs35960754; rs34968171; rs10716389; rs5792422; rs2514045; rs36075390; rs3029215; rs10160824; rs11378613; rs3029301; rs2054410; rs11378612; rs35317019; rs34917403; rs2447580; rs34428407; rs34190423; rs10896189; rs11227870; rs11227871; rs11607368; rs11820792; rs11828473; rs12274519; rs12288023; rs12363825; rs12421572; rs12787511; rs12799342; rs12800028; rs1317934; rs1993839; rs2054409; rs2126720; rs2447589; rs2447590; rs2447591; rs2447597; rs2509711; rs2509712; rs2509713; rs2509720; rs2514022; rs2514024; rs2514027; rs2514028; rs2514029; rs2885171; rs35212875; rs3758938; rs3758939; rs4608079; rs4930210; rs4930211; rs4930212; rs4930463; rs4930464; rs6591267

# Metabolic_Enzyme_27_General_References:
Not Available

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
8643

# Metabolic_Enzyme_28_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

# Metabolic_Enzyme_28_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST- 4; N-heparan sulfate sulfotransferase 4; N-HSST 4[Includes: Heparan sulfate N-deacetylase 4

# Metabolic_Enzyme_28_Gene_Name:
NDST4

# Metabolic_Enzyme_28_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 4
MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLIETTAEAECTDIKILPY
RSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESSRFQYHMVIAPGKGDIPPL
TDNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVSIIGFHKANENSLPSTQLKGF
PLNLFNNLALKDCFVNPQSPLLHITKAPKVEKGPLPGEDWTIFQYNHSTYQPVLLTELQT
EKSLSSLSSKTLFATVIQDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSL
DRYILVDIDDIFVGKEGTRMNVKDVKALLETQNLLRTQVANFTFNLGFSGKFYHTGTEEE
DEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKEFALEHGIPINMGYAVA
PHHSGVYPVHIQLYAAWKKVWGIQVTSTEEYPHLKPARYRKGFIHNSIMVLPRQTCGLFT
HTIFYKEYPGGPQELDKSIRGGELFLTILLNPISIFMTHLSNYGNDRLGLYTFVNLVNFV
QSWTNLKLQTLPPVQLAHQYFELFPEQKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVI
GPQKTGTTALYLFLLMHPSIISNLPSPKTFEEVQFFNGNNYHKGIDWYMDFFPTPSNTTS
DFLFEKSANYFHSEEAPRRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNF
YEVISTGHWAPSDLKTLQRRCLVPGWYAVHIERWLTYFATSQLLIIDGQQLRSDPATVMD
EVQKFLGVTPRYNYSEALTFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDPESRTFLSN
YYRDHNVELSKLLHRLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_28_Number_of_Residues:
872

# Metabolic_Enzyme_28_Molecular_Weight:
100717

# Metabolic_Enzyme_28_Theoretical_pI:
7.59

# Metabolic_Enzyme_28_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Not Available

# Metabolic_Enzyme_28_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity

# Metabolic_Enzyme_28_Pathway:
Not Available

# Metabolic_Enzyme_28_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_28_Signals:
1-29

# Metabolic_Enzyme_28_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_28_GenBank_ID_Protein:
11414892

# Metabolic_Enzyme_28_SwissProt_ID:
NDST4_HUMAN (Q9H3R1)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
NDST4

# Metabolic_Enzyme_28_Geneatlas_id:
NDST4

# Metabolic_Enzyme_28_hgnc_id:
HGNC:20779

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_28_Gene_Sequence:
>2619 bp
ATGAATCTTATTGTGAAACTTCGGAGAAGTTTTCGAACATTGATTGTTCTCTTAGCTACC
TTTTGCTTGGTGAGCATTGTCATTTCTGCCTATTTTCTCTACTCTGGCTACAAACAGGAA
ATGACACTTATTGAAACCACTGCAGAAGCAGAATGCACTGACATCAAAATTCTACCATAT
AGGTCAATGGAGCTGAAAACAGTTAAACCTATTGACACATCCAAAACGGACCCTACTGTC
CTTCTCTTCGTGGAGAGCCAATACTCTCAACTCGGTCAAGATATCATAGCTATTTTGGAG
TCCAGCCGATTTCAGTACCACATGGTTATTGCCCCTGGAAAGGGAGATATACCTCCTCTT
ACAGATAATGGCAAAGGGAAATATACTTTAGTTATTTATGAAAATATTCTGAAGTATGTC
AGCATGGACTCATGGAATCGAGAGCTTTTAGAAAAATACTGTGTGGAATACAGTGTTAGT
ATAATCGGTTTTCATAAAGCCAATGAGAACAGCTTACCAAGTACACAATTAAAAGGCTTT
CCGTTAAACCTTTTCAATAATCTAGCTCTAAAGGACTGTTTTGTTAACCCTCAATCTCCT
TTGCTGCATATTACCAAAGCCCCCAAGGTTGAGAAAGGCCCTCTTCCTGGGGAAGACTGG
ACTATTTTCCAATATAATCATTCAACCTACCAGCCTGTACTTTTAACTGAGTTACAGACA
GAAAAATCCCTGTCATCCTTGTCTAGCAAAACACTCTTTGCAACGGTGATTCAGGATCTG
GGGCTTCATGATGGAATTCAGAGAGTACTTTTTGGCAACAACTTGAACTTTTGGCTGCAC
AAGCTCATCTTCATAGATGCCATCTCCTTCTTGTCAGGGAAGAGGCTGACATTGTCCTTG
GACAGGTACATCCTTGTGGACATTGATGATATATTTGTTGGGAAAGAGGGAACAAGGATG
AATGTCAAAGATGTGAAGGCATTACTAGAGACTCAAAATTTACTGCGCACTCAGGTTGCA
AATTTTACCTTCAACCTTGGATTTTCAGGGAAGTTTTACCACACAGGGACTGAAGAGGAA
GATGAAGGAGATGACCTTTTACTTCGGTCTGTGGATGAGTTCTGGTGGTTTCCTCACATG
TGGAGCCACATGCAGCCCCACCTCTTCCACAACGAGTCATCTTTAGTAGAGCAGATGATT
CTCAACAAGGAATTTGCACTGGAACATGGAATACCAATCAACATGGGCTATGCTGTGGCC
CCACATCACTCAGGGGTCTACCCGGTTCACATTCAGCTGTATGCAGCTTGGAAGAAGGTC
TGGGGTATTCAAGTCACCAGCACTGAAGAATATCCACATCTGAAACCTGCCCGGTACAGA
AAGGGCTTCATTCACAATAGCATCATGGTCCTCCCTCGACAGACTTGTGGGTTGTTCACT
CACACTATTTTCTACAAAGAATATCCAGGAGGACCCCAAGAACTGGATAAAAGTATCAGA
GGAGGTGAACTTTTTCTCACAATCCTTCTAAACCCAATCAGCATTTTCATGACCCATTTA
TCAAACTATGGAAATGACCGCCTAGGGTTATATACCTTTGTGAACTTGGTCAACTTTGTG
CAGAGCTGGACCAACCTGAAATTGCAAACTCTGCCTCCAGTGCAACTGGCCCACCAGTAT
TTTGAGCTCTTCCCTGAGCAGAAAGACCCTCTATGGCAGAATCCATGTGATGATAAACGA
CACAAAGACATCTGGTCCAGAGAGAAAACTTGTGACCACTTACCAAAATTTCTAGTAATT
GGTCCACAAAAAACAGGAACAACTGCACTTTATTTATTTCTTCTTATGCATCCTTCAATC
ATCAGCAATCTCCCTAGTCCAAAGACATTTGAGGAAGTTCAGTTCTTTAATGGCAACAAC
TATCACAAAGGAATAGACTGGTATATGGACTTTTTCCCTACACCATCCAATACTACAAGT
GACTTTCTGTTTGAAAAGAGTGCTAATTACTTCCATTCGGAAGAAGCTCCAAGACGAGCC
GCATCTCTTGTCCCCAAAGCCAAGATCATCACCATCCTCATTGACCCCTCAGACAGGGCA
TACTCTTGGTACCAGCACCAACGATCACATGAAGATCCAGCTGCTCTGAGGTTCAATTTC
TATGAAGTTATTTCAACAGGACATTGGGCTCCATCTGACTTAAAAACTTTGCAGAGAAGA
TGCCTAGTACCTGGATGGTATGCAGTCCACATAGAAAGATGGCTAACTTACTTTGCTACT
TCTCAGTTGCTAATTATTGATGGACAGCAGCTGAGATCTGACCCAGCTACTGTGATGGAT
GAAGTCCAGAAGTTTCTGGGAGTTACACCTCGTTATAATTACTCTGAAGCACTAACGTTT
GATCCCCAAAAGGGTTTTTGGTGTCAATTACTGGAAGGAGGAAAGACAAAATGCCTTGGA
AAAAGCAAAGGCCGAAAATATCCACCTATGGATCCAGAGTCTAGAACGTTCCTCTCTAAT
TACTACCGAGATCATAATGTGGAACTATCCAAACTGCTACACAGACTGGGACAGCCTCTG
CCATCGTGGCTGAGACAGGAACTGCAGAAAGTGAGATAG

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AB036429

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_28_Locus:
4q25-q26

# Metabolic_Enzyme_28_SNPs:
rs6843860; rs35449662; rs475441; rs2127460; rs562049; rs528282; rs473989; rs1382999; rs511497; rs551248; rs509777; rs532923; rs578131; rs563820; rs3114034; rs477208; rs7679114; rs493304; rs1479796; rs512355; rs1893120; rs505154; rs496992; rs510657; rs1824954; rs7667960; rs503256; rs530974; rs569105; rs521110; rs550608; rs483240; rs474314; rs569917; rs479087; rs581288; rs566198; rs484404; rs481915; rs512349; rs525972; rs529078; rs6533832; rs511198; rs504346; rs505277; rs480693; rs554772; rs13105185; rs486186; rs476739; rs486441; rs9996306; rs13104877; rs481751; rs514133; rs493237; rs528793; rs532137; rs477076; rs567227; rs17584636; rs11938603; rs6533834; rs558717; rs562874; rs11721621; rs10471004; rs540954; rs482641; rs508357; rs577897; rs563857; rs554840; rs506851; rs530934; rs480995; rs537144; rs536446; rs17047634; rs561210; rs11938912; rs505967; rs10001216; rs10020287; rs557687; rs503229; rs493796; rs17047653; rs490103; rs6849060; rs2620407; rs564876; rs1561728; rs2620412; rs525465; rs2583513; rs1479797; rs1866941; rs482683; rs481922; rs541329; rs2389043; rs524021; rs561736; rs566096; rs2620411; rs1904480; rs2583516; rs516638; rs511357; rs2046050; rs479321; rs279536; rs2583517; rs998359; rs279517; rs575703; rs494047; rs1372298; rs1837800; rs481667; rs2620408; rs516109; rs2620418; rs1479799; rs279511; rs499404; rs10002221; rs11098270; rs11931706; rs2018486; rs4834448; rs11939954; rs528983; rs279534; rs9999383; rs2583515; rs10011213; rs498347; rs1020218; rs9991654; rs531435; rs6815981; rs175926; rs6820993; rs6819616; rs6813054; rs9994258; rs538932; rs530616; rs518195; rs2165543; rs580214; rs495797; rs2620413; rs1471500; rs1020219; rs495990; rs279540; rs4404563; rs1441631; rs548896; rs12642789; rs11938588; rs2389042; rs4368622; rs7668760; rs558868; rs483675; rs10005762; rs9993907; rs279520; rs7675371; rs1441638; rs7669112; rs6533830; rs6833579; rs10006039; rs517079; rs11098273; rs2620401; rs279512; rs10012243; rs566388; rs279508; rs7671429; rs10014745; rs533950; rs279537; rs7654560; rs2620409; rs1441630; rs2389040; rs1441637; rs10009553; rs505696; rs12645876; rs9998568; rs279526; rs10015390; rs2620417; rs12642484; rs2389044; rs508583; rs2583514; rs2620424; rs7695449; rs4834447; rs7666328; rs1036757; rs6830598; rs7680119; rs6825790; rs7668694; rs10033537; rs279516; rs6856543; rs1866942; rs500409; rs279538; rs7694381; rs11931643; rs1899334; rs11736926; rs10030514; rs1552025; rs279541; rs2165542; rs7674443; rs2046051; rs11930174; rs7434687; rs11937330; rs569630; rs10516606; rs279528; rs12648274; rs10022934; rs570741; rs11934279; rs11944967; rs17047540; rs1583924; rs1036758; rs536511; rs11938645; rs13128968; rs6810550; rs511927; rs1441639; rs6819065; rs523325; rs11944889; rs6810779; rs279510; rs2620415; rs6812977; rs12645885; rs11941012; rs1842264; rs279519; rs1842263; rs979513; rs17622486; rs4082347; rs498426; rs2620410; rs531594; rs6856510; rs489558; rs10001338; rs573588; rs7671596; rs7670771; rs516919; rs17047475; rs11939952; rs11098271; rs279529; rs11931484; rs12507001; rs7665509; rs11943929; rs10516607; rs17584238; rs529320; rs547928; rs10004817; rs11946779; rs533155; rs4557280; rs279524; rs559670; rs522307; rs17047428; rs2620416; rs6830279; rs10009402; rs1383002; rs526459; rs7689254; rs2892670; rs7670030; rs10007513; rs17679264; rs6811104; rs6849371; rs2583521; rs6810786; rs2028481; rs1530271; rs6843204; rs17047437; rs9884962; rs9998272; rs10516608; rs10000924; rs279505; rs9998848; rs537512; rs6533829; rs1866943; rs6836056; rs11945934; rs9992854; rs499218; rs2389041; rs479528; rs6836349; rs509127; rs279521; rs1583922; rs2620399; rs568713; rs279509; rs1383001; rs2028482; rs10516605; rs2620431; rs13120543; rs2620423; rs6849898; rs12640065; rs17047470; rs2197074; rs482935; rs4472155; rs11936553; rs6844769; rs10026970; rs17047425; rs1583923; rs7671475; rs6811143; rs750417; rs528678; rs279506; rs279522; rs471867; rs10003023; rs7673947; rs7659210; rs12648047; rs550019; rs7656008; rs530167; rs17486477; rs515976; rs11943439; rs2019200; rs9784565; rs4264850; rs12647287; rs17679144; rs12645955; rs7689395; rs11947913; rs11941001; rs4554098; rs11944811; rs6854144; rs502179; rs11736417; rs9991699; rs6811822; rs7679194; rs515070; rs7437758; rs17047468; rs10016617; rs13108625; rs7689327; rs12642116; rs2197075; rs17047537; rs7654894; rs17047524; rs6848957; rs12642139; rs1899335; rs3899756; rs920577; rs11940539; rs2019195; rs279514; rs2218251; rs11939806; rs11940470; rs10857036; rs17047495; rs6419194; rs2583523; rs6858472; rs543088; rs7696060; rs279539; rs10049937; rs4336245; rs9762896; rs279531; rs4090780; rs11734611; rs17047508; rs4530655; rs11946971; rs2083626; rs17679276; rs279518; rs10013031; rs531263; rs9762847; rs2620406; rs6856689; rs11735531; rs11935037; rs12503383; rs511901; rs10001879; rs7687949; rs9992947; rs557173; rs6824591; rs12505140; rs1441628; rs279525; rs554915; rs7663228; rs1383000; rs9997949; rs279532; rs10026976; rs6810389; rs10014430; rs9995811; rs11936530; rs10002405; rs279513; rs10006683; rs279535; rs6850601; rs13138975; rs10029337; rs17047545; rs1978938; rs17623036; rs10004858; rs573421; rs6836286; rs530485; rs899606; rs17047529; rs10222995; rs6849570; rs6844231; rs9762854; rs567976; rs17047492; rs17047419; rs17047463; rs7676598; rs2119664; rs9999215; rs10222706; rs1001815; rs1837802; rs11727410; rs17047534; rs17622677; rs6830803; rs1441633; rs6830396; rs6838296; rs7440344; rs10004337; rs11942204; rs517231; rs533585; rs10030883; rs17622627; rs17047479; rs11931244; rs6812189; rs17583437; rs17486843; rs17679753; rs1479798; rs13115130; rs10008361; rs13131064; rs547427; rs17583766; rs17047431; rs2119663; rs7674844; rs17622816; rs2620400; rs7679531; rs9684691; rs13150766; rs1441632; rs279515; rs17047542; rs11930181; rs6823958; rs6815070; rs11098276; rs4607240; rs12511884; rs11728589; rs10014003; rs1441627; rs11725345; rs11939941; rs7669788; rs17047484; rs16997326; rs7673354; rs1471499; rs10003387; rs17047410; rs13142670; rs7680862; rs17486233; rs12511801; rs482283; rs35181627; rs34847662; rs34134859; rs34045479; rs34623369; rs13128123; rs28783717; rs34597527; rs13128093; rs13152590; rs475668; rs13112177; rs10635710; rs10693090; rs34472301; rs12512835; rs13152038; rs28587893; rs34956339; rs35614861; rs35591411; rs13106842; rs35104189; rs33935748; rs34087427; rs28722150; rs33991012; rs34226280; rs34528236; rs5861203; rs34184149; rs7657227; rs33975225; rs11460236; rs11938344; rs35031671; rs6858866; rs11426438; rs477958; rs10025785; rs9991325; rs33981511; rs34574421; rs7657463; rs28687855; rs35819963; rs10016860; rs10470913; rs10025233; rs35757521; rs28678017; rs35747634; rs36059350; rs35707843; rs9685915; rs4508907; rs1600397; rs559307; rs28695346; rs35574225; rs513782; rs34883816; rs35484731; rs13131643; rs34684234; rs10033025; rs475646; rs34924132; rs28854031; rs13106858; rs2019437; rs28549159; rs35924727; rs5861202; rs33939574; rs34309563; rs491934; rs13152037; rs34452990; rs34598173; rs35164085; rs35761925; rs486615; rs13152177; rs7689538; rs34879124; rs35674542; rs3132822; rs33935242; rs13149623; rs28623688; rs13142564; rs13134223; rs34850904; rs28690869; rs34942096; rs33925339; rs10679782; rs33926517; rs2620419; rs2620425; rs6858653; rs542287; rs13112166; rs35715981; rs12640620; rs11098279; rs34741219; rs12233877; rs35081042; rs2620421; rs11460393; rs35124044; rs13144414; rs35758538; rs13149368; rs34863507; rs6848295; rs33948499; rs28596780; rs1837805; rs2620426; rs35262784; rs9760742; rs693155; rs34688407; rs34389569; rs509591; rs6810460; rs10555403; rs28602418; rs35492732; rs28622422; rs33969019; rs34614261; rs2620420; rs7340931; rs28496867; rs10008033; rs7663777; rs13152100; rs11441566; rs13133429; rs2389061; rs11435788; rs9998053; rs35971842; rs9307410; rs10651752; rs11940938; rs34190385; rs35469679; rs2583522; rs5861197; rs13124861; rs1441635; rs169416; rs34667506; rs34741350; rs11098272; rs28647687; rs33984444; rs35350644; rs7684881; rs4507381; rs17047543; rs28470302; rs6814738; rs28654828; rs28634928; rs28841108; rs33987124; rs28454168; rs534014; rs28714338; rs35061218; rs28648377; rs538924; rs17047536; rs13149624; rs8180156; rs35363930; rs6848302; rs34104366; rs10591934; rs28433013; rs35208794; rs2583519; rs34171851; rs35992236; rs6857099; rs28635970; rs36229502; rs11433054; rs35645731; rs34231121; rs36126200; rs28654447; rs28792405; rs12501272; rs34661550; rs7679175; rs9761718; rs34477080; rs34843969; rs520853; rs35529253; rs28538937; rs9995994; rs11098280; rs10529608; rs28640895; rs34863366; rs35134439; rs34398191; rs28696823; rs13104082; rs34177084; rs35327124; rs34592796; rs6848946; rs17047462; rs34866154; rs13109524; rs6848955; rs35588669; rs28396645; rs35497695; rs9760743; rs28879144; rs11405644; rs36080386; rs28563786; rs2620427; rs35088938; rs4345205; rs1899336; rs34349158; rs28457274; rs6837725; rs33953343; rs28549023; rs188089; rs11460392; rs28560246; rs28521052; rs28564632; rs2583520; rs10019977; rs279507; rs28646187; rs34479190; rs1441629; rs11396814; rs28420758; rs35979278; rs28758805; rs3077815; rs28401715; rs28523432; rs28719532; rs9762553; rs2620402; rs33951232; rs35899989; rs10446725; rs13126512; rs5861198; rs28485691; rs994218; rs34353236; rs28583163; rs34357319; rs2218250; rs34549028; rs34705577; rs35995859; rs11432779; rs5861200; rs28369395; rs13146230; rs36211109; rs530306; rs35066832; rs28727452; rs10682093; rs10615758; rs1837801; rs28433673; rs2583511; rs578285; rs6814955; rs35247707; rs35295440; rs4834449; rs35819730; rs28472632; rs35888388; rs34181479; rs2620422; rs6833754; rs11286132; rs34174566; rs6837715; rs13145875; rs4833469; rs6826385; rs10007433; rs28700231; rs33910952; rs10003921; rs33944193; rs28769381; rs35832883; rs11724358; rs34251892; rs35350731; rs28448721; rs28408781; rs34109567; rs34860647; rs10008694; rs35097855; rs35631339; rs13145278; rs34933883; rs11292247; rs1940295; rs4645229; rs1441634; rs36090257; rs28472459; rs28710395; rs36203738; rs28681493; rs13125045; rs33962515; rs11418590; rs2620414; rs35907948; rs9760755; rs10008192; rs193368; rs35095762; rs4100071; rs7665791; rs28680952; rs33921813; rs5861199; rs28806557; rs36055187; rs34780585; rs13122736; rs28496574; rs1000257; rs35605369; rs11462506; rs11441565; rs17047476; rs28533489; rs11483232; rs35442965; rs13149569; rs28719699; rs11433053; rs34037873; rs33934132; rs10010498; rs13135342; rs33929512; rs13115201; rs2389060; rs35651844; rs10526679; rs35797094; rs3077771; rs3043339; rs35075605; rs9761733; rs13122240; rs9714620; rs1837803; rs28635347; rs35146605; rs3849031; rs10020187; rs4519811; rs9761735; rs13150562; rs28393555; rs13131620; rs34072502; rs6848951; rs34196996; rs10007951; rs34055166; rs36008114; rs28434241; rs10016571; rs34139012; rs6818268; rs33988343; rs35726786; rs5861201; rs6853328; rs28521255; rs2389045; rs2859941; rs1971146; rs28633393; rs35039526; rs7671346; rs17679009; rs28668946; rs35801992; rs28569252; rs13124066; rs28493518; rs35955171; rs35597057; rs4476618; rs34354852; rs13132103; rs34793357; rs34143696; rs28611498; rs6828951; rs35423038; rs34314240; rs17679126; rs28457694; rs6855342; rs34768339; rs4001837; rs36094936; rs12639904; rs34789347; rs4361406; rs35233146; rs35705864; rs12643704; rs35967011; rs10029780; rs28548820; rs7696723; rs35633534; rs279533; rs11932147; rs33976211; rs28498191; rs35652473; rs28404350; rs34241103; rs13150826; rs28465489; rs34279473; rs28490277; rs28525562; rs35516569; rs33919888; rs35676486; rs4306976; rs5861195; rs1837799; rs28892914; rs34682679; rs13136365; rs13150779; rs10006890; rs13104087; rs28410117; rs510247; rs34569627; rs28509283; rs28812915; rs34516136; rs34776826; rs28560123; rs2583518; rs34408777; rs28464565; rs6533831; rs17047446; rs33977537; rs34602372; rs28677056; rs12650241; rs12507013; rs1837804; rs35346250; rs538817; rs35451664; rs28729973; rs2620429; rs34940157; rs35889965; rs36040898; rs35017501; rs12511633; rs6839057; rs13435021; rs35777600; rs1479802; rs3043338; rs279527; rs10018730; rs35366318; rs10030524; rs33922369; rs28612407; rs11931805; rs10654638; rs28434781; rs2127461; rs33917382; rs12641102; rs5861194; rs7663241; rs1561729; rs4834446; rs13152092; rs560680; rs486022; rs573772; rs35075359; rs35047155; rs279530; rs28730954; rs28874071; rs34412219; rs35890208; rs4361407; rs10593709; rs35536995; rs7690267; rs2583524; rs28727924; rs35903634; rs6844298; rs28412091; rs2620428; rs9759996; rs35995903; rs34207802; rs34265214; rs28773816; rs28488142; rs518872; rs13121181; rs10471002; rs35736377; rs9761726; rs28576070; rs35631469; rs36015004; rs33968646; rs6830220; rs4090781; rs34746303; rs34148880; rs17047442; rs6839089; rs279523; rs28622250; rs5861196; rs5027259; rs7693904; rs13150592; rs34909171; rs35749618; rs28587008; rs10591935; rs11350168; rs35830702; rs35473639; rs34275245; rs33922572; rs3840986; rs4299604; rs3840987; rs10013732; rs10013791; rs10013926; rs11936613; rs12640672; rs12646496; rs12646770; rs13103789; rs35438297; rs3898306; rs4512014; rs4574434; rs4640690; rs481502; rs483276; rs518645; rs528860; rs534254; rs547260; rs559777; rs560820; rs6533822; rs7682531

# Metabolic_Enzyme_28_General_References:
11087757

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
8700

# Metabolic_Enzyme_29_Name:
Hypothetical protein DKFZp666F229

# Metabolic_Enzyme_29_Synonyms:
Not Available

# Metabolic_Enzyme_29_Gene_Name:
DKFZp666F229

# Metabolic_Enzyme_29_Protein_Sequence:
>Hypothetical protein DKFZp666F229
DDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLR
HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAV
EAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV
KGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFI
MFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLAT
GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI
LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA
VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRI
NPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFL
KMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKA
VEQGGAFSNPETLDLYRDIPELQGF

# Metabolic_Enzyme_29_Number_of_Residues:
625

# Metabolic_Enzyme_29_Molecular_Weight:
69801

# Metabolic_Enzyme_29_Theoretical_pI:
6.37

# Metabolic_Enzyme_29_GO_Classification:
>>>
 Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  isoprenoid metabolism
Process:  isoprenoid biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_29_Specific_Function:
Not Available

# Metabolic_Enzyme_29_Pathway:
Not Available

# Metabolic_Enzyme_29_Reaction:
Not Available

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_29_Signals:
1-303

# Metabolic_Enzyme_29_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 6.2.1.16

# Metabolic_Enzyme_29_GenBank_ID_Protein:
52545788

# Metabolic_Enzyme_29_SwissProt_ID:
Q658Q8_HUMAN (Q658Q8)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
DKFZp666F229

# Metabolic_Enzyme_29_Geneatlas_id:
DKFZp666F229

# Metabolic_Enzyme_29_hgnc_id:
HGNC:21298

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>1878 bp
GATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGACTTCTGGGCAGAGTTCTGGAAA
TTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTTGTGGACACATCGAAAGGAATC
GCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAACTATGCAGAAAACCTCCTGCGG
CACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGGGAAGGCAAAGAGGAAATTGTG
AAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTGTTTGCAGCAGCAATGAGGAAA
ATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTACCCAACAGTGAGCACGCTGTC
GAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGGAGCTCCACGTCCCCGGACTTC
GGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAGCCAAAGCTCATCTTCTCTGTG
GAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATGGAAAAGCTGCAGCAGGTGGTT
AAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCTTATGTGTCCTCCAGAGAGAAC
ATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGATGACTTTCTTGCCACCGGCACC
AGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCCTTCAGCCACCCACTGTTCATC
ATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATGGTGCATTCCGCTGGGGGCACC
CTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAACATGACCAGCAGTGACATCCTC
CTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGGATGGTGTCCCTTCTGGCCACA
GGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTGCCCACGCCCAATGTGCTCTGG
GACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACTGGGGCCAAGTGGCTGTCAGTG
CTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGTCTCCAGATGCTCCACACGATC
CTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAGTATGTCTACAGGTGCATCAAG
AGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGACATCATCTCCTGCTTCATGGGC
CACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAGGCCCGGAACCTGGGCATGGCC
GTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGAGAGAGCGGCGAGCTGGTGTGT
ACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAACGATGAGAACGGCAACAAGTAC
AGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCTCATGGCGACTACTGCAGAATC
AACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGTGACGGCACCCTCAACCCCAAC
GGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTGGAATCCTTCGAGGAGGTGGAG
GACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAGGAGAGGGTGATCCTCTTCCTG
AAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTTAAGAGGATCCGTGACGCCATC
CGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATCCTGGAAACCAAGGGCATCCCG
TATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAACAGATCATCGCTGGAAAAGCC
GTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTGGATCTGTACCGGGACATCCCT
GAGCTGCAGGGCTTCTGA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
AL833047

# Metabolic_Enzyme_29_Chromosome_Location:
Not Available

# Metabolic_Enzyme_29_Locus:
Not Available

# Metabolic_Enzyme_29_SNPs:
Not Available

# Metabolic_Enzyme_29_General_References:
Not Available

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
8794

# Metabolic_Enzyme_30_Name:
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

# Metabolic_Enzyme_30_Synonyms:
Glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST- 3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3[Includes: Heparan sulfate N-deacetylase 3

# Metabolic_Enzyme_30_Gene_Name:
NDST3

# Metabolic_Enzyme_30_Protein_Sequence:
>Bifunctional heparan sulfate Ndeacetylase/Nsulfotransferase 3
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPY
QLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVL
IDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGF
PFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKT
PENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLS
LDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEE
EDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAV
APHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLF
THTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANF
VKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLV
IGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVT
TDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFS
FYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVM
DEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLS
SYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR

# Metabolic_Enzyme_30_Number_of_Residues:
873

# Metabolic_Enzyme_30_Molecular_Weight:
100903

# Metabolic_Enzyme_30_Theoretical_pI:
8.17

# Metabolic_Enzyme_30_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring sulfur-containing groups
Function:  sulfotransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00685:Sulfotransfer_1

# Metabolic_Enzyme_30_Signals:
1-30

# Metabolic_Enzyme_30_Transmembrane_Regions:
14-34

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 2.8.2.8

# Metabolic_Enzyme_30_GenBank_ID_Protein:
4322247

# Metabolic_Enzyme_30_SwissProt_ID:
NDST3_HUMAN (O95803)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
NDST3

# Metabolic_Enzyme_30_Geneatlas_id:
NDST3

# Metabolic_Enzyme_30_hgnc_id:
HGNC:7682

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Golgi apparatus; Golgi apparatus membrane; single-pass type II membrane protein

# Metabolic_Enzyme_30_Gene_Sequence:
>2622 bp
ATGAGTTTTATCATGAAGCTTCACAGACACTTTCAAAGAACAGTCATTCTGCTTGCCACT
TTTTGTATGGTGAGCATTATCATTTCTGCTTACTACCTGTACAGTGGCTACAAACAGGAA
AATGAACTCTCTGAGACGGCTTCAGAAGTTGACTGTGGCGACCTCCAACACCTACCATAT
CAACTAATGGAAGTGAAAGCAATGAAGCTTTTTGATGCCTCAAGGACAGACCCCACAGTC
CTAGTATTTGTAGAGAGCCAGTACTCATCTCTTGGTCAAGACATCATTATGATTCTAGAA
TCAAGTAGATTCCAGTATCACATTGAAATTGCCCCTGGAAAGGGAGATCTCCCAGTGCTT
ATAGACAAAATGAAAGGCAAATACATTCTCATTATTTATGAGAATATTTTAAAGTATATA
AATATGGATTCCTGGAATCGAAGCCTTCTAGATAAATACTGTGTAGAATATGGTGTGGGT
GTCATTGGATTCCACAAAACTAGTGAGAAGAGTGTACAGAGCTTTCAGTTAAAAGGTTTC
CCTTTTTCCATATATGGAAATCTTGCAGTAAAAGATTGTTGTATTAATCCTCATTCTCCA
TTGATTCGTGTGACCAAATCTTCCAAGCTTGAAAAAGGTTCTTTACCTGGAACTGACTGG
ACAGTTTTTCAGATTAATCATTCAGCCTATCAACCAGTAATATTTGCCAAAGTAAAGACC
CCAGAAAACCTTTCTCCTTCCATCTCTAAAGGTGCTTTTTATGCCACTATTATACATGAC
CTGGGGCTTCATGATGGAATTCAAAGGGTTCTTTTTGGCAACAACTTGAACTTTTGGCTG
CACAAGCTCATCTTCATAGATGCCATCTCCTTCTTATCAGGGAAGAGGCTGACATTGTCC
TTGGACAGGTACATTCTTGTGGATATTGATGATATATTTGTGGGAAAAGAGGGAACAAGA
ATGAACACCAATGATGTAAAGGCCCTGCTTGATACTCAGAATCTTTTGCGTGCACAAATC
ACAAATTTTACATTCAACCTGGGATTTTCAGGGAAATTTTACCATACAGGAACTGAAGAG
GAAGATGAAGGAGATGACTGTCTGTTGGGGTCTGTGGATGAGTTCTGGTGGTTTCCTCAC
ATGTGGAGCCATATGCAGCCCCACCTCTTCCACAATGAGTCATCTTTGGTGGAGCAGATG
ATTCTCAACAAAAAATTTGCCTTAGAGCACGGCATTCCAACGGACATGGGCTACGCTGTG
GCCCCTCACCATTCGGGCGTCTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAG
GTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCCAGCTAGATAC
CGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTC
ACTCACACCATTTTCTACAAAGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATC
CAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTTCATGACCCAT
TTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTT
GTGAAGAGCTGGACCAACCTGCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAG
TATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTGCGATGACAAA
CGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTA
ATAGGACCCCAGAAAACTGGTACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCC
ATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTTTAATAGAAAT
AACTACCACAGGGGGATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACT
ACCGACTTTTTGTTTGAGAAGAGTGCCAATTACTTCCACTCAGAGGAAGCCCCTAAAAGA
GCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCCTTCAGACCGA
GCATACTCCTGGTACCAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGC
TTCTACGAAGTGATCTCAGCAGGGCCCCGTGCACCCTCGGAGCTCAGAGCCTTGCAGAAG
AGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGTTTATTTCCCC
CCATTTCAGTTGCTAATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATG
GATGAAGTACAGAAGTTTCTAGGAGTCTTGCCTCATTATAATTACTCAGAAGCTTTAACG
TTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAACAAAATGCCTT
GGAAAGAGCAAAGGAAGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCA
AGCTACTATCGAGATCACAACGTGGAACTCTCAAAGCTGCTGCACAAACTGGGTCAGCCT
CTGCCATCCTGGCTGAGACAGGAGCTGCAGAAAGTAAGATAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
AF074924

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_30_Locus:
4q26

# Metabolic_Enzyme_30_SNPs:
rs617430; rs10028980; rs17049697; rs11934022; rs10012897; rs13138385; rs13152576; rs6534079; rs10857057; rs7657704; rs7656160; rs11098420; rs2389498; rs13149783; rs9999038; rs11737538; rs4328979; rs2389497; rs12500561; rs7683628; rs13125367; rs10029850; rs11734982; rs7683496; rs4569815; rs13149429; rs11731535; rs2389523; rs2892790; rs586224; rs2389527; rs2389519; rs615837; rs2389516; rs2204269; rs2389526; rs2389517; rs2030633; rs2030634; rs611659; rs11730541; rs4834672; rs2892800; rs633398; rs4834667; rs12711064; rs2389503; rs2389518; rs10026541; rs11931079; rs9999336; rs1829910; rs13134901; rs4240314; rs1589718; rs6855052; rs4834668; rs11098425; rs4616829; rs10028823; rs10018844; rs7669618; rs4833564; rs11947244; rs4428355; rs6534082; rs650460; rs11944227; rs2389520; rs1523748; rs6853879; rs6851494; rs678177; rs1996725; rs2389501; rs12642204; rs7689231; rs2389510; rs4327555; rs12506091; rs4240320; rs2389500; rs13435006; rs1872771; rs4833560; rs2389521; rs7655439; rs1589719; rs7664383; rs7655519; rs11933280; rs2389502; rs640713; rs6822996; rs10022145; rs6842491; rs788662; rs13119835; rs2389524; rs10030249; rs631271; rs11736688; rs6824418; rs6534084; rs3107483; rs1949760; rs7685455; rs1829911; rs11098424; rs4833561; rs11945921; rs17049695; rs2389512; rs586073; rs10028343; rs11933537; rs4834661; rs6842524; rs10008049; rs13127321; rs10014096; rs6816778; rs12506555; rs11940107; rs1403846; rs11934128; rs11098421; rs6823328; rs4240315; rs17049650; rs613083; rs6857232; rs788664; rs7661325; rs10020944; rs7654521; rs12508017; rs9685965; rs2389509; rs3817274; rs17593877; rs11947911; rs613443; rs17049656; rs4240319; rs687492; rs6820851; rs10023656; rs13104251; rs11727684; rs11727817; rs2892788; rs7654652; rs7689157; rs11945777; rs1319938; rs6857041; rs625546; rs6823295; rs4833563; rs11098422; rs11945329; rs17593919; rs4240318; rs10014957; rs2892799; rs11945958; rs17626497; rs2389515; rs2271577; rs607961; rs10015485; rs9992827; rs17594018; rs7671173; rs7688063; rs17049622; rs11098426; rs4240313; rs6534088; rs11946755; rs6820367; rs7687849; rs13123722; rs7435331; rs11946833; rs13114895; rs17049699; rs11098429; rs10019969; rs13142184; rs11940880; rs11726746; rs13123277; rs4318721; rs9995675; rs6818042; rs17049694; rs11947630; rs11945882; rs11944236; rs10012359; rs4558930; rs4834665; rs13114867; rs615517; rs17692850; rs11930405; rs7439663; rs2892791; rs6842393; rs6855536; rs11933599; rs7688443; rs11931769; rs6856076; rs13114621; rs6848301; rs11731179; rs10213280; rs4571408; rs11943650; rs10518291; rs10002634; rs11098430; rs6842651; rs17593793; rs2389567; rs4240316; rs2389506; rs11947605; rs6534089; rs2389508; rs4452509; rs609512; rs11098428; rs1403845; rs2271578; rs7679658; rs10033308; rs9637622; rs10021781; rs17049690; rs618177; rs17049700; rs10007553; rs10033678; rs788663; rs13139875; rs11727421; rs7695706; rs11730687; rs11728941; rs4834660; rs4147038; rs11947552; rs10015232; rs2049362; rs10020473; rs11934183; rs1916686; rs6842507; rs6822408; rs7671515; rs9996753; rs11930876; rs6842558; rs10024548; rs6820108; rs7671434; rs11942974; rs10001247; rs10004607; rs11937777; rs10440400; rs2140475; rs597881; rs6835860; rs11098427; rs11722698; rs11944865; rs13111697; rs581739; rs11934324; rs6837896; rs7678461; rs10016011; rs11945026; rs4834656; rs10025029; rs11946772; rs660905; rs6842719; rs11730611; rs11722962; rs9992747; rs3749506; rs17049570; rs6835510; rs17049627; rs6842372; rs11941660; rs6823125; rs11932087; rs7677274; rs2389513; rs6820061; rs4546313; rs17049706; rs17049693; rs10024459; rs6842557; rs13434652; rs10018706; rs10030269; rs2389504; rs593966; rs10008013; rs11931778; rs17594243; rs6813615; rs17049630; rs10016301; rs9790637; rs4397073; rs11935069; rs17049609; rs12641173; rs6825105; rs7671359; rs11940076; rs17049676; rs11942654; rs11723877; rs17515832; rs12374268; rs7671562; rs6848037; rs10023699; rs6852565; rs2892789; rs13104129; rs2892785; rs11931869; rs4834670; rs10023964; rs9996762; rs13138982; rs11931409; rs1523746; rs9637623; rs11930782; rs4833565; rs11937205; rs10001926; rs13434825; rs17049626; rs10001520; rs2389505; rs1608506; rs10016206; rs4576085; rs7687505; rs10016285; rs7699653; rs1523747; rs2389507; rs9998981; rs662581; rs11945537; rs2389514; rs7688806; rs631623; rs4131600; rs10033918; rs9684393; rs13130953; rs4147036; rs11098423; rs10031402; rs11938502; rs662086; rs9991787; rs4240317; rs6852469; rs7671232; rs10012196; rs10012051; rs2892786; rs4833566; rs10024837; rs2308027; rs4280816; rs17049625; rs17626479; rs13149888; rs17594054; rs12504529; rs10025690; rs7684275; rs16997442; rs11941062; rs17049648; rs7681830; rs10004592; rs17049698; rs17594257; rs10014055; rs9998199; rs7670397; rs6842689; rs4834673; rs10021970; rs12640268; rs13135646; rs11733562; rs13140433; rs11932297; rs13151098; rs4569819; rs10033927; rs13126882; rs12501122; rs13141841; rs7661522; rs17626520; rs2389525; rs17049588; rs4834666; rs11943088; rs1994384; rs11728724; rs2389522; rs11726838; rs11733528; rs641962; rs11939817; rs7685325; rs6534078; rs6534077; rs7671497; rs35086179; rs35147253; rs10011715; rs13118131; rs12648773; rs7436139; rs35238894; rs12648006; rs13110631; rs34916324; rs10006024; rs34883631; rs13134931; rs13144249; rs2892784; rs35050001; rs34646125; rs13110642; rs12502898; rs2389496; rs28812911; rs13134916; rs2389495; rs35267341; rs10020284; rs33930999; rs28729926; rs34730378; rs13119849; rs7683791; rs2389499; rs35245189; rs12501652; rs4001572; rs13110657; rs13123909; rs13133776; rs35257604; rs7662255; rs34893788; rs12501383; rs28648504; rs34795498; rs7436325; rs35359278; rs5861377; rs7435948; rs34835262; rs12498683; rs1608505; rs35263017; rs3080149; rs28847022; rs36035970; rs34812479; rs34623333; rs3830507; rs34564513; rs6853684; rs4833567; rs12505156; rs13131380; rs36227842; rs35826097; rs35938936; rs17049649; rs34302716; rs10027013; rs10607535; rs35776915; rs28848859; rs33922704; rs34143377; rs28715892; rs35580866; rs9991087; rs1523744; rs10702072; rs5861375; rs28697099; rs2892787; rs35491780; rs35821057; rs13121129; rs7666861; rs35683434; rs11335648; rs35034865; rs36208859; rs35573813; rs28562324; rs35216924; rs13149170; rs10628437; rs28734874; rs4833562; rs13134451; rs34452190; rs28781349; rs4566725; rs13134833; rs33985434; rs28669076; rs34924654; rs10633685; rs10002892; rs11416507; rs11722023; rs2271579; rs11448394; rs35054481; rs1343827; rs13131971; rs28706008; rs35094555; rs35218485; rs41278065; rs35704864; rs4834664; rs673682; rs17515651; rs12505418; rs28851582; rs34872510; rs35237651; rs36207620; rs28667401; rs13137083; rs4400066; rs36127253; rs28886020; rs11728964; rs35139409; rs34756619; rs1523749; rs35995808; rs35073718; rs34315750; rs11439726; rs12331617; rs676802; rs35375764; rs36006756; rs34255267; rs28789108; rs34909956; rs28500762; rs4546315; rs5742375; rs13127368; rs11298940; rs28723489; rs10004800; rs35754873; rs5861383; rs35715840; rs4147039; rs28847597; rs11384076; rs28576396; rs7356311; rs17515561; rs34008240; rs36117603; rs11281529; rs10003652; rs5861378; rs5861380; rs35988831; rs35960010; rs35910994; rs788661; rs13131623; rs11297151; rs28567841; rs13132331; rs9968544; rs28631338; rs34054720; rs4404621; rs34242038; rs10033412; rs34918708; rs35648060; rs6828552; rs35502256; rs28771156; rs34872625; rs28683619; rs35946502; rs34418586; rs35051708; rs35138500; rs11737224; rs5861376; rs6824718; rs28819697; rs13123381; rs11737229; rs33994401; rs34285969; rs34185290; rs34558995; rs34655188; rs34872487; rs35694467; rs34764099; rs28507199; rs9996857; rs35017662; rs28711393; rs28646146; rs28555974; rs6856765; rs11724386; rs35872631; rs11299569; rs4502754; rs28634983; rs5861382; rs35792741; rs34595271; rs34626006; rs11947071; rs35099667; rs36070709; rs13113258; rs10633686; rs28484271; rs10007959; rs17593863; rs13114249; rs35851865; rs35051152; rs28665669; rs11322429; rs28856120; rs28740899; rs34290697; rs28665169; rs28393351; rs33984401; rs35661296; rs35210682; rs28885399; rs11298939; rs34475822; rs4834657; rs33972233; rs9307452; rs28619162; rs34213306; rs10568846; rs28558085; rs10030449; rs13135500; rs35844977; rs10027893; rs4557347; rs28434240; rs35754081; rs34345840; rs35475347; rs28728238; rs6847359; rs34826732; rs33931637; rs33936644; rs10014402; rs11336961; rs10007381; rs35591587; rs28682376; rs34714560; rs34711397; rs34563259; rs28766305; rs12505582; rs11728950; rs12108668; rs10656718; rs28396926; rs28479964; rs28507472; rs35554727; rs28889086; rs10021128; rs35235550; rs35018183; rs34017200; rs11419568; rs11347319; rs11294350; rs28688245; rs4362895; rs4834658; rs35307549; rs7654695; rs10005348; rs34004725; rs34405308; rs28753894; rs10025515; rs35983699; rs28600918; rs33977562; rs10007918; rs34646523; rs10031257; rs35067389; rs4502667; rs35641856; rs28776305; rs41278063; rs28826087; rs35524586; rs10440401; rs34190534; rs28524963; rs28536042; rs28711185; rs36098020; rs34994076; rs28421577; rs35749089; rs36218730; rs13106276; rs28396217; rs34419266; rs33966390; rs10669730; rs36119137; rs28631152; rs28668316; rs7661076; rs34171033; rs35652422; rs28690846; rs28708693; rs36139871; rs13120016; rs35492744; rs34730310; rs10024910; rs34835669; rs7439873; rs34182759; rs666558; rs10681234; rs13132346; rs34872062; rs36219518; rs35381491; rs34782963; rs5861379; rs36229372; rs34176697; rs35789417; rs12511554; rs28589481; rs10025979; rs28498433; rs11380294; rs10027703; rs35876590; rs5861381; rs10535482; rs13125461; rs28667022; rs34850426; rs10005512; rs28515963; rs28768382; rs34238547; rs10030057; rs4437319; rs34834977; rs35294396; rs7665014; rs10004528; rs35238803; rs36053074; rs11729027; rs35816742; rs35254931; rs35528360; rs36214652; rs34466659; rs10050326; rs10014154; rs13136897; rs34463969; rs35137516; rs28399774; rs35650624; rs35112049; rs34804902; rs33926182; rs33979318; rs28603319; rs3838634; rs34835050; rs35641809; rs28378646; rs35077679; rs34248952; rs34101813; rs35192544; rs28687476; rs11408271; rs33927682; rs34723948; rs10006223; rs34660107; rs13109564; rs4519863; rs28374287; rs10011099; rs2389511; rs6845921; rs13129847; rs34639699; rs644797; rs1523745; rs10569298; rs10023858; rs35188223; rs2389566; rs13103629; rs35250714; rs35647802; rs36081446; rs28508556; rs28627299; rs34891564; rs36092065; rs12505642; rs35621837; rs35982667; rs13113193; rs10025340; rs28430981; rs28375657; rs4544776; rs34091625; rs35433749; rs28823876; rs35284850; rs13109168; rs35204114; rs10005659; rs10024765; rs34165051; rs34224588; rs7686670; rs613149; rs33953463; rs34004705; rs34525909; rs35754899; rs12499751; rs28630407; rs6848598; rs4147040; rs35472465; rs10213202; rs13125397; rs33923588; rs10613667; rs35760279; rs33971782; rs34293412; rs28882407; rs35553303; rs11396935; rs17049590; rs9993556; rs6148636; rs28369617; rs33928766; rs28667620; rs10682796; rs34548920; rs34644680; rs34915366; rs34436506; rs11934512; rs28656282; rs28625833; rs28478577; rs4526047; rs35943639; rs35276919; rs10000049; rs11727769; rs11935016; rs11946941; rs12509230; rs1318459; rs1319061; rs17594447; rs2138009; rs2254204; rs2254215; rs2254218; rs2291416; rs2389491; rs2389492; rs2389493; rs3134; rs34514948; rs35612621; rs4438821; rs4479780; rs4577651; rs582448; rs608228; rs6534074; rs656079; rs7687673; rs7688055

# Metabolic_Enzyme_30_General_References:
9915799; 12975309

# Metabolic_Enzyme_30_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7551

# Macromolecular_Interacting_Partner_1_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_1_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_1_Locus:
6p21.3

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_1_References:
16888030; 16888805; 16912650

# Macromolecular_Interacting_Partner_2_ID:
8490

# Macromolecular_Interacting_Partner_2_Name:
ACOT12 protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
ACOT12

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>ACOT12 protein
MERPAPGEVVMSQAIQPAHATARGELSAGQLLKWIDTTACLAAEKHAGVSCVTASVDDIQ
FEETARVGQVITIKAKVTRAFSTSMEISIKVMVQDMLTGIEKLVSVAFSTFVAKPVGKEK
IHLKPVTLLTEQDHVEHNLAAERRKVRLQHEDTFNNLMKESSKFDGQ

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
18327

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.15

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03061:4HBT

# Macromolecular_Interacting_Partner_2_Signals:
Not Available

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
58477543

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q5FWE9_HUMAN (Q5FWE9)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
ACOT12

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
ACOT12

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:24436

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>504 bp
ATGGAGCGGCCGGCGCCCGGCGAGGTGGTCATGAGCCAAGCCATCCAGCCGGCGCACGCC
ACTGCGCGCGGCGAGCTGAGCGCGGGGCAGCTGCTCAAGTGGATCGACACCACCGCCTGC
CTGGCGGCTGAGAAACATGCTGGAGTTTCCTGCGTTACAGCCTCAGTGGATGACATACAG
TTTGAGGAGACAGCTAGAGTTGGACAAGTTATAACCATCAAAGCAAAAGTTACTAGAGCA
TTCAGCACAAGCATGGAGATCAGTATCAAGGTCATGGTACAGGATATGCTCACTGGCATT
GAGAAGCTTGTTAGTGTGGCTTTCTCCACATTTGTAGCCAAACCAGTTGGAAAAGAAAAG
ATTCATTTAAAACCAGTCACACTTCTAACTGAACAAGATCATGTGGAACATAATCTGGCT
GCTGAGAGAAGGAAAGTTCGATTACAACATGAAGATACCTTTAACAATTTAATGAAGGAA
AGTAGCAAATTTGATGGTCAGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
BC089437

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_2_Locus:
5q14.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10371; rs34607174; rs6452403; rs4703517; rs11745197; rs4235653; rs7717804; rs7733558; rs4703520; rs11957050; rs6881927; rs1896775; rs7702227; rs6452399; rs7734127; rs6872459; rs7727053; rs6452406; rs10039986; rs6452402; rs4704723; rs11749621; rs4703516; rs10078088; rs7728156; rs7716302; rs4277893; rs10942262; rs6452401; rs7714558; rs6885431; rs10053334; rs4703518; rs6452405; rs6452400; rs11742598; rs3857368; rs10042996; rs6882140; rs12514594; rs7729671; rs13357760; rs6871569; rs6881492; rs11954685; rs11740623; rs4703834; rs6872684; rs7703082; rs17230425; rs7713774; rs4703835; rs6860593; rs6886158; rs6881271; rs4703836; rs4704722; rs7446307; rs11955415; rs13174473; rs10035223; rs10942261; rs12517108; rs13155682; rs11747702; rs11950107; rs10038566; rs13169852; rs11950658; rs13163821; rs12520468; rs6890955; rs12523386; rs11960480; rs12517153; rs13186206; rs6881812; rs7706593; rs10040901; rs9688138; rs6873953; rs10057287; rs6881478; rs12519060; rs7719033; rs4703519; rs11741065; rs12108697; rs13154060; rs6859712; rs7736224; rs13154467; rs10078484; rs7726536; rs7735423; rs11750649; rs7735449; rs13357762; rs9686517; rs7718935; rs7706867; rs2059894; rs6890483; rs2162974; rs11953727; rs13171460; rs11954484; rs9686399; rs12697702; rs9546; rs1366597; rs35316986; rs13178695; rs34577490; rs9885322; rs35612570; rs6872090; rs28714197; rs6873688; rs6881957; rs13181700; rs35550583; rs10617260; rs34743880; rs34766269; rs35219024; rs11313535; rs34955738; rs9885510; rs34729119; rs11741735; rs7720907; rs35132583; rs34443861; rs34138509; rs9885325; rs36123812; rs35339139; rs34126274; rs10058787; rs34394766; rs13181989; rs13157817; rs35452641; rs13176170; rs35476333; rs11343919; rs35917298; rs34385090; rs13186560; rs35627535; rs6879397; rs7446383; rs35604690; rs6890957; rs35626276; rs3052892; rs6874204; rs35315461; rs10533341; rs35810370; rs13186689; rs35863495; rs11443702; rs34070636; rs7717621; rs34905257; rs11271359; rs35532389; rs36052619; rs35399330; rs13170632; rs28874676; rs34235173; rs34804859; rs13157241; rs34764200; rs33997120; rs10058788; rs13155027; rs11343063; rs13170970; rs34892080; rs11739092; rs10058800; rs34623194; rs13355076; rs13181953; rs36197694; rs34921781; rs34307954; rs4133039; rs11291371; rs13181707; rs35675731; rs13185752; rs10037433; rs13154229; rs34714548; rs7737568; rs34817412; rs4704721; rs34896188; rs34513795; rs34115148; rs35399912; rs28515696; rs10626819; rs34655510; rs3052908; rs11385870; rs35003041; rs34760824; rs34588330; rs10626203; rs33957145; rs34521130; rs10053706; rs10056565; rs10063615; rs10076567; rs12188470; rs12519433; rs13190050; rs13190332; rs1366598; rs16878614; rs2042980; rs2059892; rs33989062; rs34094852; rs35367896; rs4502795; rs4703521; rs4703522; rs4703523; rs6868743; rs6875430; rs6889795; rs723045; rs723046; rs7734902

# Macromolecular_Interacting_Partner_2_General_References:
12477932

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8605

# Macromolecular_Interacting_Partner_3_Name:
Citrate lyase beta like

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
CLYBL

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Citrate lyase beta like
LQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEEL
IAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
103

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11401

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
7.70

# Macromolecular_Interacting_Partner_3_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF03328:HpcH_HpaI

# Macromolecular_Interacting_Partner_3_Signals:
Not Available

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
57160623

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
Q5JVC0_HUMAN (Q5JVC0)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
CLYBL

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
CLYBL

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:18355

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>961 bp
GAAAGCGTCTCTAGCAGCTGATATCCCCAGACTTGGATATAGTTCCTCATCCCATCACAA
GTACATCCCCCGGAGGGCAGTGCTTTATGTACCTGGAAATGATGAAAAGAAAATAAAGAA
GATTCCATCCCTGAATGTAGATTGTGCAGTGCTCGACTGTGAGGATGGAGTGGCTGCAAA
CAAAAAGAATGAAGCTCGACTGAGAATTGTAAAAACTCTTGAAGACATTGATCTGGGCCC
TACTGAAAAATGTGTGAGAGTCAACTCAGTTTCCAGTGGTCTGGCGGAAGAAGACCTAGA
GACCCTTTTGCAATCCCGGGTCCTTCCTTCCAGCCTGATGCTACCAAAGGTGGAAAGTCC
TGAAGAAATCCAGTGGTTTGCAGACAAATTTTCATTCCACTTAAAAGGCCGAAAACTTGA
ACAACCAATGAATTTAATCCCTTTTGTGGAAACTGCAATGGGTTTGCTCAATTTTAAGGC
AGTGTGTGAAGAAACCCTGAAGGTCGGGCCTCAAGTAGGTCTCTTTCTAGATGCAGTCGT
TTTTGGAGGAGAAGACTTTCGAGCCAGCATAGGTGCAACAAGTAGTAAAGAAACCCTGGA
TATTCTCTACGCCCGGCAAAAGATTGTTGTCATAGCGAAAGCCTTTGGTCTCCAAGCCAT
AGATCTGGTGTACATTGACTTTCGAGATGGAGCTGGGCTGCTTAGACAGTCACGAGAAGG
AGCCGCCATGGGCTTCACTGGTAAGCAGGTGATTCACCCTAACCAAATTGCCGTGGTCCA
GGAGCAGTTTTCTCCTTCCCCTGAAAAAATTAAGTGGGCTGAAGAACTGATTGCTGCCTT
TAAAGAACATCAACAATTAGGAAAGGGGGCCTTTACTTTCCAAGGGAGTATGATCGACAT
GCCATTACTGAAGCAGGCCCAGAACACTGTTACGCTTGCCACCTCCATCAAGGAAAAATG
A

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AL137139

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:13

# Macromolecular_Interacting_Partner_3_Locus:
13q32

# Macromolecular_Interacting_Partner_3_SNPs:
rs3783185; rs17577293; rs35680839; rs1924104; rs11617041; rs2281757; rs8002438; rs7997714; rs12019809; rs9300573; rs2281756; rs12584825; rs1886033; rs9513680; rs7333559; rs9557330; rs6491538; rs2296117; rs7992643; rs7318415; rs7998712; rs7331251; rs11616403; rs12323012; rs6491539; rs9582352; rs1040997; rs9554647; rs7318038; rs12018767; rs7317993; rs2281755; rs7992592; rs9517908; rs9554648; rs9585264; rs6491536; rs2038695; rs9585263; rs11842450; rs9557333; rs1924105; rs6491537; rs7322872; rs7994827; rs2763950; rs725834; rs2039933; rs2793762; rs2763947; rs2761153; rs2057490; rs912284; rs1886031; rs1886035; rs2793760; rs912288; rs2763948; rs2038693; rs968535; rs2057489; rs912290; rs2390323; rs2761174; rs1028710; rs2806280; rs2806285; rs1000022; rs2793745; rs1886034; rs6491526; rs9554619; rs754003; rs2806295; rs9300571; rs2806281; rs912285; rs9585198; rs2806284; rs12866973; rs12184508; rs9557276; rs11838894; rs7328481; rs9554641; rs2761156; rs9517818; rs2793761; rs2761169; rs9557286; rs912289; rs1105576; rs9554620; rs6491534; rs7993372; rs2793749; rs12430063; rs4772245; rs2806290; rs7333752; rs7336903; rs3742254; rs8002555; rs4772238; rs2806283; rs9517847; rs1924099; rs2761163; rs2763940; rs754004; rs10775026; rs7984263; rs7994744; rs11069375; rs4592516; rs2761173; rs2793746; rs9585195; rs7986079; rs7982561; rs10508039; rs9557284; rs4771344; rs9513673; rs7989959; rs4772246; rs8002475; rs9517906; rs9513648; rs7982186; rs7327267; rs7326626; rs7333425; rs11069379; rs7334942; rs2390357; rs1022845; rs4772225; rs9585171; rs2038694; rs2806300; rs4772239; rs9517898; rs7981650; rs878418; rs912283; rs9557318; rs7334071; rs2761152; rs2298066; rs9517825; rs12427607; rs4511391; rs7338186; rs9513660; rs9585157; rs1107450; rs2153672; rs2806279; rs9557311; rs7336899; rs2806297; rs2390354; rs7331804; rs9554625; rs2761158; rs7991703; rs2761165; rs7327909; rs7996352; rs7999726; rs7995737; rs9300564; rs2761171; rs2761155; rs9554617; rs9517863; rs9300569; rs9585250; rs4340181; rs4772229; rs7323117; rs4525350; rs7317032; rs7984112; rs927596; rs7996792; rs9554636; rs2793748; rs9300565; rs9513675; rs6491521; rs17473570; rs9582350; rs16956874; rs6491531; rs4418926; rs7328417; rs7333886; rs9554624; rs12100265; rs17612226; rs9513658; rs9585169; rs2761154; rs7992587; rs2793758; rs17576658; rs7319374; rs2793787; rs12430038; rs10508040; rs9557309; rs7317678; rs17612198; rs7994564; rs8002591; rs9554618; rs7335639; rs11069374; rs4771343; rs12873858; rs4772240; rs9517814; rs17577167; rs9557290; rs9557321; rs7316944; rs9513664; rs12856441; rs9554639; rs2057488; rs7337354; rs2806278; rs2806307; rs1341399; rs12584570; rs8001493; rs4267173; rs6491525; rs9582351; rs2893010; rs9585252; rs9585161; rs2793769; rs9517885; rs7321513; rs6491532; rs9513653; rs7328387; rs9634449; rs2806298; rs7330733; rs4772222; rs721922; rs17612087; rs9554642; rs9517877; rs4334138; rs12584833; rs7326777; rs9557319; rs9300567; rs12431270; rs4771342; rs12877095; rs9557317; rs7330589; rs9517829; rs2806306; rs9517895; rs9557297; rs8000862; rs9557298; rs11620246; rs7328242; rs7995431; rs9513665; rs9517905; rs1924107; rs2806310; rs17612107; rs11616808; rs2806275; rs9585243; rs7335739; rs9554637; rs11840104; rs9557325; rs7994234; rs17657985; rs1555589; rs7323189; rs9513667; rs7991377; rs9585162; rs912659; rs9513672; rs9585211; rs9517869; rs7994919; rs11839315; rs2761167; rs1107382; rs4483710; rs9557308; rs7335678; rs10083230; rs12868139; rs2806302; rs9585226; rs11839716; rs2806309; rs9554634; rs4564437; rs9517871; rs9300570; rs7981201; rs2806286; rs12427494; rs9300561; rs12868090; rs9582329; rs11840327; rs7328023; rs4384480; rs4772236; rs912287; rs8000571; rs7326772; rs7998536; rs11839651; rs7323953; rs9517892; rs2761168; rs9517889; rs2057487; rs10083271; rs7332098; rs9517899; rs1125436; rs7319987; rs2282401; rs7139930; rs12430048; rs9513647; rs9585242; rs2250311; rs7330630; rs1886030; rs11842056; rs2793763; rs7319505; rs4772249; rs9557282; rs11839563; rs4771340; rs4290347; rs9554633; rs9585178; rs1028711; rs9517893; rs11069372; rs7139402; rs9513661; rs7999987; rs9513663; rs8000435; rs9517830; rs9557293; rs2806292; rs9585234; rs7994852; rs9554645; rs6491523; rs9585231; rs2793741; rs16956730; rs7987714; rs9670678; rs7995755; rs9517886; rs9517813; rs16956921; rs2181608; rs2793751; rs11839875; rs17576929; rs9585245; rs2182037; rs12875247; rs7324176; rs2390355; rs1987492; rs9582336; rs9517817; rs6491533; rs2761162; rs7986248; rs9300568; rs4772227; rs11839443; rs9517864; rs9634517; rs34667146; rs4772241; rs9517891; rs7318060; rs9513654; rs2806303; rs9517901; rs16956916; rs12429300; rs9513674; rs7332426; rs16956961; rs2390359; rs2761157; rs4377025; rs7995280; rs7993002; rs1028712; rs11616546; rs16956764; rs7988259; rs10851107; rs9585164; rs7985592; rs9585175; rs12877564; rs9517878; rs9557268; rs9585233; rs11069382; rs17658053; rs9585248; rs11839991; rs9585208; rs2763939; rs7326142; rs9513650; rs7319992; rs7333543; rs7985956; rs9670010; rs2763943; rs7987600; rs2793785; rs7984587; rs9517808; rs11069381; rs12869989; rs7338007; rs7998807; rs12866699; rs2763944; rs9517824; rs2000148; rs9557267; rs7983983; rs7993694; rs4411369; rs12018070; rs2181607; rs16957038; rs9582347; rs7986437; rs1111867; rs9300572; rs9517861; rs10454027; rs2027442; rs4439619; rs12585089; rs9513649; rs4505173; rs4772224; rs9300562; rs1544189; rs11616786; rs9517835; rs9585153; rs4772233; rs7317837; rs12184851; rs11843986; rs1555590; rs2793786; rs9557273; rs9554644; rs9517831; rs9557291; rs3831038; rs7989523; rs7988767; rs6491535; rs17611399; rs7329724; rs2793784; rs9557272; rs12427504; rs11840934; rs9557320; rs7982629; rs11842082; rs2761166; rs9517867; rs9517887; rs9585200; rs6491528; rs2793764; rs9582348; rs1125435; rs2761159; rs9554631; rs9585216; rs2390302; rs7335229; rs11619446; rs10851109; rs7987145; rs9517860; rs7318411; rs9513656; rs9557306; rs16957003; rs4772237; rs1924100; rs9517820; rs2806277; rs9585207; rs2806301; rs2806305; rs9585173; rs2761164; rs9585185; rs11842371; rs2763949; rs7986083; rs9582344; rs7490120; rs7981731; rs7321720; rs9517904; rs9557288; rs8002734; rs4771341; rs9554616; rs9517884; rs9517872; rs7317914; rs4288858; rs11840555; rs3033552; rs9517862; rs16956964; rs2806288; rs4772247; rs2236583; rs9557301; rs2763945; rs11841969; rs16956883; rs16957012; rs9517832; rs9513644; rs9557316; rs7320176; rs12429794; rs1924108; rs9557307; rs12584897; rs9517821; rs7995103; rs10454527; rs17473598; rs9517876; rs9517811; rs4360797; rs9517816; rs2761175; rs4771347; rs9585166; rs16956821; rs7986249; rs9582335; rs7319880; rs958764; rs9557304; rs9582345; rs12427647; rs10220173; rs9517897; rs17611302; rs2806293; rs8000012; rs9585186; rs9557271; rs2763938; rs9517837; rs9585244; rs9585172; rs11841056; rs7998088; rs1924110; rs9557323; rs9517827; rs9554646; rs2806304; rs9742582; rs2793754; rs9585206; rs17577153; rs2761161; rs912286; rs2390356; rs2806296; rs8000609; rs16956828; rs2793742; rs9513671; rs6491527; rs16956889; rs9557287; rs17657201; rs7995312; rs2806308; rs4424774; rs2761172; rs9557310; rs4400905; rs11843710; rs9557302; rs7328196; rs999631; rs2761170; rs4772235; rs7985416; rs7337811; rs2763946; rs7319139; rs11619680; rs11840467; rs7325119; rs9582331; rs1924109; rs9557269; rs12429830; rs13378481; rs9300557; rs9582338; rs7328521; rs869323; rs2763934; rs1886032; rs11616689; rs9582328; rs41281112; rs12873611; rs34411915; rs35611394; rs34078213; rs3742255; rs12873851; rs9585262; rs34625836; rs28642354; rs35177836; rs12869625; rs7995068; rs7986754; rs12017062; rs35024669; rs9585266; rs35061922; rs35546044; rs28698863; rs35358394; rs12018768; rs1924106; rs34875340; rs2209086; rs35968589; rs9585257; rs12874770; rs9585261; rs9517909; rs28660130; rs34773665; rs34896012; rs9585272; rs7992743; rs9517911; rs9557334; rs10707455; rs9557329; rs9585269; rs9585265; rs7327776; rs34366931; rs9585258; rs9582353; rs10635703; rs12017613; rs2209087; rs10598307; rs9585260; rs9517912; rs9557332; rs9585271; rs35025545; rs11435009; rs12872031; rs12561106; rs12873057; rs28592795; rs9585273; rs9557328; rs34151390; rs9585256; rs35912155; rs11362669; rs977610; rs2181610; rs9585267; rs2296116; rs9585270; rs9585259; rs7982619; rs9585205; rs35003302; rs10220015; rs35823298; rs34969571; rs11618807; rs9585147; rs12021159; rs7322953; rs11271366; rs7324313; rs7989192; rs9300563; rs9517874; rs9513677; rs9585160; rs7337684; rs35567603; rs36097438; rs34070975; rs11449148; rs9517804; rs13329008; rs9517823; rs9557322; rs12868239; rs11317797; rs12865200; rs34073523; rs9554643; rs28627688; rs9513639; rs35342610; rs12019528; rs35430864; rs34526549; rs9557283; rs12858482; rs36091331; rs7324907; rs35483940; rs7317490; rs8000287; rs10597168; rs9517881; rs11841929; rs9585154; rs9517846; rs9557270; rs34410535; rs35949973; rs34021200; rs10592053; rs34772610; rs34861520; rs9585152; rs34939381; rs35699728; rs7322521; rs9513642; rs1040996; rs35662060; rs35774183; rs9554635; rs34088240; rs7983817; rs9585224; rs34985378; rs2147624; rs7139645; rs9513651; rs9582346; rs3032477; rs34250062; rs10568410; rs3032445; rs12019531; rs12875806; rs34486737; rs34750084; rs12017299; rs11463686; rs7996829; rs9513669; rs11366826; rs9585230; rs4771345; rs2793765; rs9585227; rs4772234; rs2793766; rs41281114; rs10533615; rs9582332; rs12869202; rs35379429; rs12429721; rs34363176; rs5806134; rs34924763; rs28580696; rs9585220; rs11419450; rs9582339; rs1610001; rs9585217; rs7331354; rs7988332; rs7981233; rs12560998; rs2793737; rs9585149; rs35727678; rs12867987; rs4772226; rs10645961; rs34374186; rs12232034; rs10549994; rs36075018; rs2793755; rs9585194; rs35412408; rs5806131; rs11840479; rs9517855; rs35952137; rs35232603; rs12869622; rs35750065; rs10677584; rs9585201; rs35047223; rs35613958; rs7327405; rs12855403; rs9517850; rs35916895; rs12020709; rs9585183; rs9513679; rs34146197; rs34684474; rs34556034; rs11335800; rs36015545; rs11366362; rs9513662; rs35466928; rs35844376; rs35948793; rs9554627; rs11305509; rs12868722; rs4255648; rs12861278; rs2390358; rs36129096; rs34164127; rs9517851; rs35257355; rs34063235; rs9557314; rs35635065; rs7334733; rs9513646; rs34276188; rs10597169; rs35445984; rs10677824; rs9796290; rs35391365; rs2806291; rs28726082; rs927595; rs36015417; rs2793750; rs35508052; rs2806282; rs13378365; rs35423396; rs11278066; rs7994927; rs5806138; rs12016773; rs36044234; rs7984935; rs34500560; rs11309587; rs9585236; rs36145554; rs33916976; rs9557280; rs2793759; rs9517842; rs10642327; rs12875158; rs2806276; rs35128777; rs33929981; rs12866242; rs2793744; rs12021220; rs12867593; rs4771339; rs4772242; rs12856515; rs9557303; rs1963727; rs9513652; rs35624361; rs12862106; rs10645320; rs9585221; rs10648017; rs7325085; rs11343579; rs9557289; rs12873987; rs9582343; rs28373539; rs9585155; rs35229641; rs36013244; rs7992451; rs2806287; rs7986698; rs728604; rs35893746; rs9585204; rs28460044; rs10083293; rs34582077; rs2793747; rs12875920; rs9513641; rs10556030; rs5806135; rs9517812; rs34631016; rs9585219; rs9585212; rs9554638; rs9517873; rs34206687; rs9513659; rs36094711; rs9585144; rs9585177; rs7996041; rs34513643; rs7993488; rs34742862; rs35938901; rs12871842; rs9517852; rs2793743; rs34556416; rs12583116; rs12428299; rs28630466; rs5806132; rs9300559; rs34184534; rs35582976; rs35442779; rs35794092; rs12017446; rs28535907; rs35588884; rs36054864; rs11300050; rs35941109; rs11617836; rs9517807; rs7335906; rs12561426; rs35020187; rs9517870; rs9585156; rs35916119; rs28662865; rs9557326; rs12430026; rs35436226; rs9585253; rs34909317; rs35970090; rs7996371; rs16956897; rs11069380; rs12865204; rs9517880; rs35492194; rs2181606; rs34774913; rs35610893; rs9517843; rs9585228; rs7988250; rs34026761; rs4001025; rs34000442; rs9585176; rs9517865; rs9554628; rs33921953; rs9585191; rs10614481; rs9645897; rs9557264; rs7988572; rs12323058; rs5806139; rs11838666; rs35820957; rs9585184; rs35531654; rs9557300; rs7997298; rs33994560; rs7997104; rs11322280; rs7322080; rs9557275; rs35421489; rs35122845; rs36120094; rs2806294; rs10697990; rs5009289; rs9517836; rs9585150; rs12871547; rs9585241; rs35654270; rs9740926; rs34546130; rs9554622; rs9557274; rs1125310; rs10698265; rs28655761; rs7335847; rs34217364; rs7320067; rs34444426; rs9585222; rs12865205; rs9517822; rs12876701; rs34463702; rs11617075; rs34142988; rs28690058; rs35606459; rs7984121; rs4772232; rs11375965; rs10527051; rs34459686; rs4772243; rs2793757; rs10561602; rs35769084; rs2763937; rs9557279; rs34065607; rs35279065; rs28758716; rs9585255; rs35982336; rs11295981; rs35593548; rs9517833; rs9557285; rs2763941; rs12871537; rs34919433; rs34521848; rs35403713; rs34410635; rs4620824; rs9585145; rs4468465; rs34452564; rs9582334; rs4771338; rs7992348; rs35449822; rs34006709; rs5806136; rs9585238; rs35744796; rs7492046; rs7336931; rs13378364; rs9585196; rs10625169; rs10633371; rs35255826; rs9517858; rs28607319; rs10638638; rs9517848; rs12854991; rs34417938; rs35178164; rs9585235; rs28622077; rs34025247; rs7336414; rs12017577; rs35662106; rs34874271; rs34706273; rs12873782; rs9557294; rs9557265; rs35512772; rs35252192; rs11463227; rs9557299; rs35360400; rs12868198; rs10547821; rs35149509; rs35684540; rs10643696; rs11407509; rs2793740; rs10631675; rs34591731; rs11488858; rs35846449; rs9517828; rs11399409; rs9652119; rs11408587; rs4581571; rs4448786; rs9585180; rs9517894; rs2761160; rs9796140; rs2793739; rs10592189; rs9517839; rs9585232; rs9513676; rs36013148; rs11453486; rs12873787; rs9554630; rs11413739; rs2793768; rs17577328; rs9582330; rs11428657; rs11840697; rs10580515; rs12868144; rs34164966; rs9585254; rs12873329; rs34877692; rs4772228; rs13378360; rs9557292; rs9517853; rs34127469; rs5806140; rs34783138; rs34168768; rs36062611; rs9582349; rs7996029; rs9585215; rs34966114; rs2181611; rs9517868; rs34256215; rs34844714; rs35539387; rs9585229; rs2763936; rs4772231; rs34487469; rs12870132; rs4772244; rs10587468; rs9796139; rs7323206; rs12019527; rs9585214; rs35378080; rs5806137; rs35339021; rs1555592; rs9585158; rs9582341; rs34817821; rs12020266; rs34180901; rs34493491; rs11843458; rs35821572; rs9585192; rs2793788; rs11423267; rs35513599; rs35590185; rs9630323; rs35802185; rs9585174; rs34774349; rs34128794; rs9585237; rs7988847; rs5806133; rs12020817; rs34558107; rs9517849; rs9517826; rs9513657; rs10577448; rs9517806; rs9585197; rs2390303; rs1970474; rs34727243; rs9513668; rs5806130; rs10675151; rs9517834; rs2763942; rs9517883; rs9557278; rs10570896; rs7324908; rs9517840; rs2181609; rs7322341; rs12585649; rs9585181; rs12866164; rs9585163; rs9585179; rs35241030; rs10643154; rs35027014; rs35911559; rs28454189; rs9585146; rs9517890; rs12861546; rs34903136; rs12864654; rs12855629; rs11488857; rs4772248; rs7992906; rs9585218; rs4362246; rs34065473; rs34854735; rs12862668; rs2806289; rs35340874; rs2015510; rs35553024; rs35159870; rs9517809; rs9300560; rs36019690; rs10542003; rs28421311; rs7326701; rs3033587; rs9585182; rs34277836; rs35273988; rs34884800; rs9554640; rs12016925; rs9517859; rs9517882; rs9517845; rs9513643; rs9517903; rs28497020; rs34634591; rs10603999; rs11300591; rs34668722; rs11355981; rs35156803; rs10613474; rs9585209; rs35152575; rs5806141; rs7328182; rs4988681; rs4771346; rs9557281; rs9517841; rs7983978; rs9517854; rs9517875; rs34257176; rs35102124; rs35191910; rs12858356; rs28417881; rs9585202; rs4001024; rs9585193; rs9585151; rs34349227; rs36158602; rs34319588; rs34935488; rs12868025; rs35877939; rs12875051; rs35480092; rs12874188; rs36046210; rs1555591; rs11619740; rs7986124; rs4771337; rs17473738; rs11419451; rs2793767; rs2253561; rs2793753; rs9585247; rs35402626; rs35604496; rs7334160; rs2806299; rs7322262; rs9805698; rs9557324; rs34517548; rs11362747; rs34075621; rs7981210; rs9585148; rs2763935; rs869324; rs5806129; rs35113728; rs33913059; rs35215455; rs9513638; rs9517802; rs12876075; rs35123470; rs12874996; rs869325; rs35614015; rs1040998; rs10851106; rs11617237; rs12020463; rs12876007; rs17611025; rs1924102; rs1924103; rs2390337; rs2763932; rs2793783; rs35065101; rs4238223; rs4238224; rs4772250; rs4772253; rs6491518; rs7338383; rs7338818; rs7982361; rs8002910; rs9513637; rs9517914; rs9585276; rs9645895; rs9645896

# Macromolecular_Interacting_Partner_3_General_References:
Not Available

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8651

# Macromolecular_Interacting_Partner_4_Name:
OTTHUMP00000030471

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>
OTTHUMP00000030471MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPS
GSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGW
FLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYSPWLQMPCGP

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
16137

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.66

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Signals:
Not Available

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
Q5TF43_HUMAN (Q5TF43)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
ACSS1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
ACSS1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:16091

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AL080312

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_4_Locus:
Not Available

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
Not Available

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8890

# Macromolecular_Interacting_Partner_5_Name:
CGI-14 protein variant

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>CGI14 protein variant
GAGSGWACLGDLGQVQSLNPGPAGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPG
IVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRH
TLGQQEVEVDGLTAYVAGERPDPLGPRSQPACQVAHDPPRACPLCSQGTKTLSGSIAPMD
VCVRHFLQATGQ

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
192

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
19973

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.84

# Macromolecular_Interacting_Partner_5_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Carbohydrate transport and metabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
62088282

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q59FV8_HUMAN (Q59FV8)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:24262

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>579 bp
GGGGCCGGCTCGGGGTGGGCCTGCTTGGGGGACCTGGGCCAGGTGCAAAGTCTGAATCCA
GGTCCCGCAGGGCACTCAGTGGCTGACCTGCGGGCGGCAGAGGATGCTGTGTGGAGCGGA
GCCACCTTCATCACCCACCTCTTCAACGCCATGCTGCCTTTCCACCACCGCGACCCAGGC
ATCGTGGGGCTCCTGACCAGCGACCGGCTGCCCGCAGGCCGCTGCATCTTCTATGGGATG
ATTGCAGATGGCACGCACACCAACCCCGCCGCCCTGCGGATCGCCCACCGTGCCCATCCC
CAGGGGCTGGTGCTGGTCACCGATGCCATCCCTGCCTTGGGCCTGGGCAACGGCCGGCAC
ACGCTGGGACAGCAGGAAGTGGAAGTGGACGGTCTGACGGCCTACGTGGCAGGTGAGCGC
CCTGACCCACTGGGTCCCAGGTCCCAGCCCGCATGCCAGGTGGCCCACGACCCCCCCAGA
GCCTGCCCTCTCTGCTCTCAAGGCACCAAGACGCTGAGTGGCAGCATAGCCCCAATGGAC
GTCTGTGTCCGGCACTTCCTGCAGGCCACAGGTCAGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AB209351

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Locus:
Not Available

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00042

Beginning of HMDB00043
# Accession_No:
HMDB00043

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-14 11:21:21

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Betaine

# Description:
Betaine or trimethylglycine is a methylated derivative of glycine.  It functions as a methyl donor in that it carries and donates methyl functional groups to facilitate necessary chemical processes. The donation of methyl groups is important to proper liver function, cellular replication, and detoxification reactions. Betaine also plays a role in the manufacture of carnitine and serves to protect the kidneys from damage. Betaine has also been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th Ed, p1341)

# Synonyms:
(Carboxymethyl)trimethylammonium hydroxide inner salt; (Trimethylammonio)acetate; 1-Carboxy-N,N,N-trimethylmethanaminium inner salt; 1-carboxy-N,N,N-trimethyl-Methanaminium; 1-carboxy-N,N,N-trimethyl-Methanaminium hydroxide; Abromine; Aminocoat; Betafin; Betafin BCR; Betafin BP; Betaine; Cystadane; Ektasolve EE; FinnStim; Glycine betaine; Glycocoll betaine; Glycylbetaine; Greenstim; Loramine AMB 13; Loramine AMB-13; Lycine; N,N,N-Trimethylglycine; Oxyneurine; Rubrine C; Trimethylaminoacetate; Trimethylaminoacetic acid; Trimethylglycine; Trimethylglycocoll; a-Earleine; alpha-Earleine; trimethylbetaine Glycine

# Chemical_IUPAC_Name:
2-trimethylammonioacetate

# Chemical_Formula:
C5H11NO2

# Chemical_Structure:
tbl_chemical:::HMDB00043_ZOOM.png:::119283151093782155

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00043_THUMB.png:::119283150910844650

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Organic Salts

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
cation; anion; quaternary ammonium salt; carboxylic acid salt

# Taxonomy_Biofunction:
Osmolyte; Component of Glycine, serine and threonine metabolism; Component of Methionine metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
117.07898

# Molecular_Weight_Avg:
117.14634

# Smiles_String_isomeric:
C[N+](C)(C)CC([O-])=O

# Smiles_String_canonical:
C[N+](C)(C)CC([O-])=O

# KEGG_Compound_ID:
C00719

# BioCyc_ID:
BETAINE

# PubChem_CID:
247

# PubChem_SID:
2165; 11537950; 7853805; 8145492; 10503467; 8150529; 150977; 12075420; 4422026; 841599; 3138572; 7978780; 7985507; 3985

# OMIM_ID:
250940

# Metagene_ID:
Not Available

# BiGG_ID:
35786

# Wikipedia_ID:
Betaine

# METLIN_ID:
287

# Ref_ID:
9357926; 12560353; 11522934; 12551843; 11569700; 11101581; 11737741; 12399266; 3546377; 9732980; 16082628; 16282556

# ChEBI_ID:
17750

# CAS_Registry_Number:
107-43-7

# InChI:
InChI=1/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

# Synthesis_Reference:
Journal of Physical Chemistry  (1990),  94(5),  1768-74.

# Melting_Point:
293 oC ( Soicke, H., Fitoterapia 1988,  V59(1),  P73-5); 301 oC dec.

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
611.0 mg/mL at 19 oC [YALKOWSKY,SH & DANENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
1.86 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.69 [Predicted by ALOGPS]; -4.93 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Betaine.mol:::1132723803125187364

# SDF_File_[Text]:
tbl_chemical:::HMDB00043.sdf:::119283150576698389

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00043.pdb:::119283150743379361

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_PRESAT_expanded_2.gif:::114460751934022109

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_presat.zip:::117771063555967593

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041001_P00_01_HW_1DP_Assigned.png:::114659863448940034

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::107-43-7-presat_JM.GIF:::1132883787031709634

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041001_P00_01_HW_1DP_PRESAT_1.zip:::114460785426616486

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38.jpg:::114168476843860901

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38.zip:::114168476840860186

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041001_P00_01_HW_1DC_38_Assigned.jpg:::114322768817422051

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29.jpg:::114495493377492504

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29.zip:::114495493416554525

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041001_P00_01_HW_2DHSQC_29_Assigned.jpg:::114495493433298286

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Betaine.gif:::1132732102000118802

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00043_peaks.txt:::1156309506995697027

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Betaine_C.gif:::1132737665729794101

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00043_peaks.txt:::1156310698608995963

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00043L.png:::117555262019868691; Medium Energy:tbl_ms:::HMDB00043M.png:::117555267104726345; High Energy:tbl_ms:::HMDB00043H.png:::117555270979784450

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000069.png:::116890825632897374

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000069.txt:::116890825660945219

# Cellular_Location:
Cytoplasm; Extracellular; mitochondria

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Bladder; Epidermis; Fibroblasts; Gonads; Gut; Intestine; Kidney; Liver; Liver Predominantly; Pancreas; Placenta; Platelet; Prostate; Skeletal Muscle; Skin; Spleen; Stratum Corneum; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; Breast Milk; Urine

# Concentration_[Normal]:
Urine	18.6 (4.868-32.4)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	3546377
Urine	49.6 (6.4-92.7)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	9732980
Blood	82.0 (20.0-144.0)	umol/L	Adult:>18_yrs_old	Both	Normal	9732980 


# Concentration_[Abnormal]:
Urine	6.0 (0.0-16.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Lung Cancer	HMP experimental


# Associated_Disorders:
Lung Cancer; Prostate Cancer; Thalassemia Trait; Tumour Necrosis

# Pathway_Names:
Methionine metabolism

# Pathway_Images:
Methionine_Metabolism.jpg

# KEGG_Images:
map00271

# Pathway_Graphs:
Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5831

# Metabolic_Enzyme_1_Name:
Betaine--homocysteine S-methyltransferase 1

# Metabolic_Enzyme_1_Synonyms:
Not Available

# Metabolic_Enzyme_1_Gene_Name:
BHMT

# Metabolic_Enzyme_1_Protein_Sequence:
>Betainehomocysteine Smethyltransferase 1
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ

# Metabolic_Enzyme_1_Number_of_Residues:
406

# Metabolic_Enzyme_1_Molecular_Weight:
44999

# Metabolic_Enzyme_1_Theoretical_pI:
7.04

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

# Metabolic_Enzyme_1_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism

# Metabolic_Enzyme_1_Reaction:
trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.1.1.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
1522683

# Metabolic_Enzyme_1_SwissProt_ID:
BHMT1_HUMAN (Q93088)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
BHMT

# Metabolic_Enzyme_1_Geneatlas_id:
BHMT

# Metabolic_Enzyme_1_hgnc_id:
HGNC:1047

# Metabolic_Enzyme_1_PDB_ID:
1LT8

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1221 bp
ATGCCACCCGTTGGGGGCAAAAAGGCCAAGAAGGGCATCCTAGAACGTTTAAATGCTGGA
GAGATTGTGATTGGAGATGGAGGGTTTGTCTTTGCACTGGAGAAGAGGGGCTACGTAAAG
GCAGGACCCTGGACTCCTGAAGCTGCTGTGGAGCACCCAGAAGCAGTTCGCCAGCTTCAT
CGAGAGTTCCTCAGAGCTGGCTCAAACGTCATGCAGACCTTCACCTTCTATGCGAGTGAA
GACAAGCTGGAGAACAGGGGCAACTATGTCTTAGAGAAGATATCTGGGCAGGAAGTCAAT
GAAGCTGCTTGCGACATCGCCCGACAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGA
GGAGTGAGTCAGACACCTTCATACCTTAGCTGCAAGAGTGAAACTGAAGTCAAAAAAGTA
TTTCTGCAACAGTTAGAGGTCTTTATGAAGAAGAACGTGGACTTCTTGATTGCAGAGTAT
TTTGAACACGTTGAAGAAGCTGTGTGGGCAGTTGAAACCTTGATAGCATCCGGTAAACCT
GTGGCAGCAACCATGTGCATTGGCCCAGAAGGAGATTTGCATGGCGTGCCCCCCGGCGAG
TGTGCAGTGCGCCTGGTGAAAGCAGGAGCATCCATCATTGGTGTGAACTGCCACTTTGAC
CCCACCATTAGTTTAAAAACAGTGAAGCTCATGAAGGAGGGCTTGGAGGCTGCCCAACTG
AAAGCTCACCTGATGAGCCAGCCCTTGGCTTACCACACTCCTGACTGCAACAAGCAGGGA
TTCATCGATCTCCCAGAATTCCCATTTGGACTGGAACCCAGAGTTGCCACCAGATGGGAT
ATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATTGGCGGGTGCTGT
GGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTT
TTGCCACCAGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGACATGCACACCAAA
CCCTGGGTTAGAGCAAGGGCCAGGAAGGAATACTGGGAGAATCTTCGGATAGCCTCAGGC
CGGCCATACAACCCTTCAATGTCAAAGCCAGATGGCTGGGGAGTGACCAAAGGAACAGCC
GAGCTGATGCAGCAGAAAGAAGCCACAACTGAGCAGCAGCTGAAAGAGCTCTTTGAAAAA
CAAAAATTCAAATCACAGTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U50929

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q13.1-q15

# Metabolic_Enzyme_1_SNPs:
rs3733890; rs585800; rs1002735; rs1050824; rs542852; rs649514; rs492842; rs651852; rs567754; rs6453430; rs10037045; rs506500; rs6862287; rs6875201; rs6894156; rs7700970; rs3797546; rs621678; rs622087; rs694290; rs16876548; rs4421087; rs10474577; rs573372; rs558133; rs612855; rs34504683; rs16876528; rs16876527; rs6893970; rs6860725; rs478667; rs16876547; rs34004238; rs686764; rs619100; rs1862227; rs11955042; rs35815247; rs3756548; rs562487; rs16876512; rs3756547; rs10037809; rs672347; rs1050825; rs672346; rs11541208; rs35041410; rs4703772; rs1804620; rs2909853; rs13164347; rs6893715; rs13160271; rs35064627; rs35826365; rs918417; rs34861837; rs34308482; rs35913757; rs34267463; rs35639243; rs1644005; rs35373899; rs5868950; rs35563215; rs4020527; rs35261961; rs35571558; rs10071440; rs35884202; rs34576335; rs7722216; rs10044894; rs35617181; rs11955653; rs1316776; rs1627316; rs16876498; rs16876500; rs16876503; rs1717566; rs1915705; rs1915706; rs2364596; rs2461248; rs2909854; rs490268; rs586199; rs600473; rs603896; rs617219; rs631305; rs644623; rs645112; rs7356530; rs7732845; rs955897; rs964320

# Metabolic_Enzyme_1_General_References:
8798461; 10075673; 9281325; 9681996; 12818402

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5433

# Metabolic_Enzyme_2_Name:
Choline dehydrogenase, mitochondrial precursor

# Metabolic_Enzyme_2_Synonyms:
CHD; CDH

# Metabolic_Enzyme_2_Gene_Name:
CHDH

# Metabolic_Enzyme_2_Protein_Sequence:
>Choline dehydrogenase, mitochondrial precursor
MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLT
EDPAERVLLLEAGPKDVRAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVL
YWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRY
RGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSA
ACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAIN
SPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLR
KVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAY
QVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAP
FRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENL
RVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR

# Metabolic_Enzyme_2_Number_of_Residues:
594

# Metabolic_Enzyme_2_Molecular_Weight:
65402

# Metabolic_Enzyme_2_Theoretical_pI:
8.47

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  FAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
 ||
>>>
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
Choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_2_Pathway:
map00260  Glycine, serine and threonine metabolism

# Metabolic_Enzyme_2_Reaction:
choline + acceptor = betaine aldehyde + reduced acceptor

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05199:GMC_oxred_C;
PF00732:GMC_oxred_N

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.99.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
21759795

# Metabolic_Enzyme_2_SwissProt_ID:
CHDH_HUMAN (Q8NE62)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CHDH

# Metabolic_Enzyme_2_Geneatlas_id:
CHDH

# Metabolic_Enzyme_2_hgnc_id:
HGNC:24288

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Mitochondrion (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1785 bp
ATGTGGTGTCTCCTACGAGGCCTGGGCCGGCCTGGAGCCCTGGCACGGGGAGCCCTGGGG
CAGCAGCAATCCCTGGGTGCCCGGGCCCTGGCCAGCGCAGGCTCTGAGAGCCGGGACGAG
TACAGCTATGTGGTGGTGGGCGCGGGCTCGGCGGGCTGCGTGCTGGCTGGGAGGCTCACG
GAGGACCCCGCCGAGCGCGTGCTGCTGCTGGAGGCCGGGCCCAAGGACGTGCGCGCGGGG
AGCAAGCGGCTCTCGTGGAAGATCCACATGCCCGCGGCCCTGGTGGCCAACCTGTGCGAC
GACAGGTACAACTGGTGCTACCACACAGAGGTGCAGCGGGGCCTGGACGGCCGCGTGCTG
TACTGGCCACGCGGCCGCGTCTGGGGTGGCTCCTCATCCCTCAATGCCATGGTCTACGTC
CGTGGGCACGCCGAGGACTACGAGCGCTGGCAGCGCCAGGGCGCCCGCGGCTGGGACTAC
GCGCACTGCCTGCCCTACTTCCGCAAGGCGCAGGGCCACGAGCTGGGCGCCAGCCGGTAC
CGGGGCGCCGATGGCCCGCTGCGGGTGTCCCGGGGCAAGACCAACCACCCGCTGCACTGC
GCATTCCTGGAGGCCACGCAGCAGGCCGGCTACCCGCTCACCGAGGACATGAATGGCTTC
CAGCAGGAGGGCTTCGGCTGGATGGACATGACCATCCATGAAGGCAAACGGTGGAGCGCA
GCCTGTGCCTACCTGCACCCAGCACTGAGCCGCACCAACCTCAAGGCCGAGGCCGAGACG
CTTGTGAGCAGGGTGCTATTTGAGGGCACCCGTGCAGTGGGCGTGGAGTATGTCAAGAAT
GGCCAGAGCCACAGGGCTTATGCCAGCAAGGAGGTGATTCTGAGTGGAGGTGCCATCAAC
TCTCCACAGCTGCTCATGCTCTCTGGCATCGGGAATGCTGATGACCTCAAGAAACTGGGC
ATCCCTGTGGTGTGCCACCTACCTGGGGTTGGCCAGAACCTGCAAGACCACCTGGAGATC
TACATTCAGCAGGCATGCACCCGCCCTATCACCCTCCATTCAGCACAGAAGCCCCTGCGG
AAGGTCTGCATTGGTCTGGAGTGGCTCTGGAAATTCACAGGGGAGGGAGCCACTGCCCAT
CTGGAAACAGGTGGGTTCATCCGCAGCCAGCCTGGGGTCCCCCACCCGGACATCCAGTTC
CATTTCCTGCCATCCCAAGTGATTGACCACGGGCGGGTCCCCACCCAGCAGGAGGCTTAC
CAGGTACATGTGGGGCCCATGCGGGGCACGAGTGTGGGCTGGCTCAAACTGAGAAGTGCC
AATCCCCAAGACCACCCTGTGATCCAGCCCAACTACTTGTCAACAGAAACTGATATTGAG
GATTTCCGTCTGTGTGTGAAGCTCACCAGAGAAATTTTTGCACAGGAAGCCCTGGCTCCG
TTCCGAGGGAAAGAGCTCCAGCCAGGAAGCCACATTCAGTCAGATAAAGAGATAGATGCC
TTTGTGCGGGCAAAAGCCGACAGCGCCTACCACCCCTCGTGCACCTGTAAGATGGGCCAG
CCCTCCGATCCCACTGCCGTGGTGGATCCGCAGACAAGGGTCCTCGGGGTGGAAAACCTC
AGGGTCGTCGATGCCTCCATCATGCCTAGCATGGTCAGCGGCAACCTGAACGCCCCCACA
ATCATGATCGCAGAGAAGGCAGCTGACATTATCAAGGGGCAGCCTGCACTCTGGGACAAA
GATGTCCCTGTCTACAAGCCCAGGACGCTGGCCACCCAGCGCTAA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
BC034502

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3p21.1

# Metabolic_Enzyme_2_SNPs:
rs9001; rs34974961; rs2241808; rs7641850; rs17053532; rs35375185; rs35064726; rs930367; rs4687590; rs6793451; rs6807783; rs4687591; rs9835128; rs2015498; rs6445607; rs4687747; rs920253; rs13317328; rs6445608; rs6801605; rs7643016; rs2118421; rs9812916; rs2289206; rs7620929; rs3774616; rs2289207; rs7647880; rs3774617; rs11718497; rs2276838; rs7632578; rs6804251; rs7626693; rs12634827; rs4687589; rs11716282; rs34500349; rs4687748; rs7634578; rs9855967; rs11914948; rs13321117; rs9854886; rs2884632; rs2196663; rs9824744; rs12637132; rs9877386; rs2289209; rs9836592; rs6445606; rs7625247; rs9863776; rs2241807; rs893368; rs2289208; rs11714712; rs4563403; rs4687744; rs11130381; rs4687588; rs12485507; rs4234642; rs17053530; rs12485510; rs12676; rs3209093; rs34336629; rs35642771; rs34905899; rs11391630; rs5849008; rs10663777; rs4687746; rs2118422; rs4687749; rs4687750; rs35580724; rs2164815; rs35890881; rs6807496; rs3079408; rs13080845; rs10636132; rs35892434; rs6782485; rs930366; rs10713985; rs10703989; rs34971544; rs35544897; rs11711312; rs9872403; rs13088829; rs35491417; rs9860224; rs13069101; rs13086547; rs9881815; rs34939200; rs34021192; rs34884918; rs11287903; rs9830723; rs34004134; rs35518479; rs34827407; rs9848701; rs7644115; rs34858459; rs28744591; rs28563804; rs34378181; rs10626142; rs3079411; rs10154841; rs1025689; rs10490844; rs11919668; rs14165; rs1561303; rs17641133; rs2232330; rs2232335; rs2232336; rs2232337; rs2232338; rs2276839; rs2289205; rs28385739; rs34241531; rs35403974; rs3733075; rs3755817; rs3774618; rs4261872; rs4364157; rs4371507; rs4687587; rs4687743; rs6445605; rs7614233; rs7620619; rs7627178; rs7636327; rs7637792; rs7650686; rs877483; rs877484; rs881883; rs893362; rs893363; rs9878562; rs999514; rs999515

# Metabolic_Enzyme_2_General_References:
Not Available

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5270

# Metabolic_Enzyme_3_Name:
Pyruvate dehydrogenase protein X component, mitochondrial precursor

# Metabolic_Enzyme_3_Synonyms:
Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX

# Metabolic_Enzyme_3_Gene_Name:
PDHX

# Metabolic_Enzyme_3_Protein_Sequence:
>Pyruvate dehydrogenase protein X component, mitochondrial precursor
MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSK
NIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTL
RFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTAT
PTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPH
AYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF
IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD
ELATRFLKSFKANLENPIRLA

# Metabolic_Enzyme_3_Number_of_Residues:
501

# Metabolic_Enzyme_3_Molecular_Weight:
54123

# Metabolic_Enzyme_3_Theoretical_pI:
9.09

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring acyl groups
Function:  transferase activity, transferring groups other than amino-acyl groups
Function:  acyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Energy production and conversion 

# Metabolic_Enzyme_3_Specific_Function:
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
Not Available

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00198:2-oxoacid_dh;
PF00364:Biotin_lipoyl;
PF02817:E3_binding

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.1.12

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2316040

# Metabolic_Enzyme_3_SwissProt_ID:
ODPX_HUMAN (O00330)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDHX

# Metabolic_Enzyme_3_Geneatlas_id:
PDHX

# Metabolic_Enzyme_3_hgnc_id:
HGNC:21350

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_3_Gene_Sequence:
>1506 bp
ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTC
CCTGGCTGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCCGTAAGCCGCGGA
GCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAA
GGTGAAGCGGTGAGTGCTGGAGATGCATTATGTGAAATTGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCAAGTGATGATGGAATCTTGGCCAAAATCGTGGTTGAAGAAGGAAGTAAA
AATATACGGCTAGGTTCACTAATTGGTTTGATAGTAGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCCAAAGACGTAGGTCCTCCACCACCAGTTTCAAAACCTTCAGAGCCTCGC
CCCTCACCAGAACCACAGATTTCCATCCCTGTCAAGAAGGAACACATACCCGGGACACTA
CGGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAACACTCACTGGATGCTAGC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTTGTC
CAGTTGAAACAAACGGGCAAGATTACCGAGTCCAGACCAACTCCAGCCCCCACAGCCACT
CCCACAGCACCTTCGCCCCTACAGGCCACATCTGGACCATCTTATCCCCGGCCTGTGATC
CCACCAGTATCAACTCCCGGACAACCCAATGCAGTGGGCACATTCACTGAAATCCCCGCC
AGCAATATTCGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGTACTGTACCTCAT
GCATATGCTACTGCTGACTGTGACCTTGGAGCTGTTTTAAAAGTTAGGCAAGATCTGGTC
AAAGATGACATTAAAGTATCAGTAAATGATTTTATCATCAAGGCAGCAGCTGTTACCCTT
AAACAAATGCCAGATGTTAATGTAAGCTGGGATGGAGAGGGCCCAAAGCAACTGCCATTT
ATTGACATTTCAGTGGCTGTGGCAACAGATAAAGGCTTACTTACTCCAATCATAAAAGAT
GCTGCTGCTAAAGGTATCCAGGAAATTGCTGACTCTGTAAAGGCTCTATCAAAGAAAGCA
AGAGATGGAAAATTGTTGCCTGAAGAATACCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGACGAATTTACTGCAGTGATTAACCCTCCTCAGGCCTGCATTTTG
GCGGTTGGGAGGTTCCGACCTGTGCTGAAGCTCACTGAGGATGAAGAGGGAAATGCCAAA
CTGCAGCAGCGCCAGCTCATAACAGTCACAATGTCAAGTGACAGTCGAGTGGTTGATGAC
GAACTGGCAACCAGGTTTCTTAAAAGTTTTAAAGCAAACCTAGAGAATCCTATCCGACTT
GCCTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF001437

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_3_Locus:
11p13

# Metabolic_Enzyme_3_SNPs:
rs11539202; rs497582; rs34582941; rs7808; rs9326; rs3210067; rs16926653; rs3210066; rs3210064; rs3210065; rs2732555; rs2986408; rs2915205; rs2986412; rs2985149; rs2761820; rs2915197; rs2985150; rs2956105; rs2986406; rs511776; rs2956081; rs2956126; rs2243929; rs2956128; rs496653; rs2986404; rs2956077; rs1326945; rs2986409; rs504034; rs1991648; rs2985403; rs2732551; rs1998912; rs2762963; rs614668; rs2915203; rs2915202; rs733567; rs7940226; rs2956107; rs7938962; rs7115217; rs7947650; rs7950996; rs746124; rs2762954; rs11032937; rs2956106; rs2732557; rs2915190; rs496620; rs12294125; rs2025779; rs2915201; rs3852517; rs2767047; rs7925118; rs2986403; rs2762956; rs2915199; rs2956103; rs2915227; rs2915198; rs2986402; rs2025780; rs2915191; rs2732559; rs2762962; rs2915189; rs2762959; rs2915183; rs2762953; rs2986410; rs3794165; rs7941930; rs12279553; rs12274490; rs11032927; rs17435469; rs6484749; rs7119958; rs17348711; rs2732565; rs6484747; rs2767044; rs2986405; rs11032935; rs3794163; rs1326944; rs17433496; rs2915200; rs2956098; rs2243948; rs10488801; rs12292719; rs12286538; rs10836326; rs3852515; rs10488803; rs12270487; rs1011518; rs520658; rs2031686; rs2915193; rs7119807; rs2181876; rs17434946; rs10488804; rs724714; rs7104984; rs11608116; rs7479823; rs2732558; rs10488802; rs11032928; rs7117719; rs12294047; rs2985402; rs7952208; rs12275339; rs2956100; rs2767038; rs11605993; rs967505; rs2767043; rs2915204; rs2253128; rs2985405; rs11032963; rs2732562; rs6484748; rs2217479; rs3794166; rs967506; rs10836324; rs11600718; rs2767035; rs17348697; rs7114970; rs12283763; rs11032948; rs3794161; rs11032938; rs11032926; rs7119524; rs12099088; rs10742331; rs3932539; rs10836323; rs17363135; rs12275275; rs7941937; rs11032944; rs2956123; rs2915181; rs2985401; rs589626; rs568932; rs2732554; rs7932205; rs11032956; rs2732564; rs12288594; rs7117023; rs11032943; rs17434808; rs10768110; rs9666748; rs10768106; rs9666905; rs12295537; rs2031687; rs1011519; rs10836327; rs11032960; rs11032940; rs2956087; rs2767034; rs12270826; rs11032942; rs3118073; rs522436; rs2761819; rs12289996; rs10768105; rs9971607; rs2761821; rs17349298; rs12099276; rs12286412; rs9667504; rs2986413; rs2281809; rs12288628; rs7924969; rs12283472; rs7929287; rs2761822; rs16926479; rs2762960; rs2915187; rs11601737; rs2956102; rs10466392; rs7936426; rs10742332; rs2767039; rs10768108; rs1746940; rs12276735; rs9665797; rs17362114; rs2985151; rs7931814; rs2762957; rs10488805; rs12295452; rs2732560; rs12282098; rs1748073; rs12385808; rs11032941; rs2956099; rs11606580; rs2915195; rs3763924; rs10488807; rs4375465; rs1409717; rs2732563; rs7115153; rs12295408; rs7105901; rs4417241; rs2767042; rs9667348; rs7945524; rs2986407; rs2031685; rs16926457; rs2956101; rs2767037; rs3794157; rs2767036; rs11032969; rs3794162; rs12275911; rs2985404; rs10488806; rs10836322; rs11605972; rs956130; rs1049333; rs1049311; rs35560997; rs34398018; rs17850649; rs36047324; rs3210068; rs1063351; rs4756180; rs34358212; rs2956104; rs3980625; rs28677799; rs12294397; rs7936015; rs11032945; rs12282419; rs5791023; rs2767046; rs11032966; rs34108758; rs3980628; rs2767045; rs3045650; rs11032957; rs12283866; rs12292363; rs34547087; rs36061427; rs35950140; rs11032936; rs3831063; rs12279631; rs7924507; rs10734433; rs12800045; rs12792494; rs34160844; rs2915196; rs11347782; rs11032971; rs12789653; rs17349031; rs12281172; rs34095132; rs2986411; rs35979260; rs12799433; rs526240; rs2956124; rs34514805; rs502063; rs11032925; rs11291680; rs28450089; rs35931541; rs12292931; rs34104501; rs33992348; rs35384167; rs12417952; rs860731; rs2274134; rs28475621; rs12807481; rs28682443; rs7109473; rs35258745; rs679919; rs3841705; rs11603724; rs11032952; rs34466417; rs12282382; rs35802689; rs7948977; rs28626757; rs3118498; rs12275277; rs3044759; rs837014; rs10709327; rs5791024; rs12279549; rs11032934; rs7123633; rs3215780; rs12795625; rs34345153; rs3980627; rs12799276; rs35335444; rs2732556; rs11032954; rs3980692; rs34890448; rs35176869; rs11032967; rs12270152; rs11032962; rs11032950; rs12272825; rs36026065; rs34896834; rs33975041; rs494892; rs11824801; rs12286583; rs12804006; rs11032929; rs34570842; rs12292505; rs2915192; rs2477157; rs34797155; rs2767040; rs12291039; rs12294594; rs2732561; rs12099355; rs3118071; rs12281384; rs12273153; rs12279952; rs2761823; rs9630149; rs3852519; rs2956127; rs33982446; rs11032961; rs3891918; rs35345329; rs12276679; rs12280293; rs12274680; rs5791025; rs3852516; rs3118072; rs35425265; rs34867844; rs12805200; rs11032959; rs12288060; rs34515348; rs34937302; rs4756182; rs11032931; rs10734430; rs10742330; rs4486662; rs12289218; rs7936983; rs1430857; rs11032933; rs11032970; rs7938431; rs11600805; rs2915194; rs11032947; rs1409718; rs12385809; rs7123595; rs11296610; rs7945013; rs10633958; rs12274383; rs11032958; rs4756181; rs35740352; rs11032964; rs12286442; rs35362345; rs11032951; rs12789820; rs12283435; rs10742329; rs11032932; rs10580926; rs11032946; rs35919979; rs11032939; rs12416846; rs12269970; rs35371988; rs41512444; rs35227178; rs35090822; rs3852518; rs35664323; rs17364197; rs28675015; rs2732566; rs1049306; rs1049307; rs11605600; rs11606257; rs11606871; rs12226454; rs12273271; rs12281914; rs12285752; rs12293733; rs12293749; rs12361884; rs12574930; rs12785657; rs1326947; rs1326948; rs16926673; rs16926689; rs17347979; rs17436343; rs1887229; rs2016814; rs2016821; rs2025776; rs2025777; rs2116084; rs2762951; rs2762969; rs2767033; rs2915208; rs2956108; rs2956109; rs2956110; rs2956111; rs2956112; rs2956113; rs2956114; rs2956116; rs2956120; rs2986414; rs2986417; rs2986418; rs2986420; rs2986421; rs3763925; rs3763926; rs3763929; rs3763930; rs3763931; rs3763932; rs3763933; rs3763934; rs3763935; rs3763937; rs3794170; rs3794171; rs3794172; rs3818393; rs3818396; rs3818397; rs3818401; rs7109857; rs7110223; rs7113708; rs7116411; rs7126300; rs7126659; rs7129830; rs7484223; rs891546; rs984690

# Metabolic_Enzyme_3_General_References:
9242632; 9399911; 9467010; 9110174

# Metabolic_Enzyme_3_References:
11223528; 14612446; 7592481; 7898450

# Metabolic_Enzyme_4_ID:
6833

# Metabolic_Enzyme_4_Name:
Ephrin type-B receptor 2 precursor

# Metabolic_Enzyme_4_Synonyms:
Tyrosine-protein kinase receptor EPH-3; DRT; Receptor protein-tyrosine kinase HEK5; ERK; Renal carcinoma antigen NY-REN-47

# Metabolic_Enzyme_4_Gene_Name:
EPHB2

# Metabolic_Enzyme_4_Protein_Sequence:
>Ephrin typeB receptor 2 precursor
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK
LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKK
GMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG

# Metabolic_Enzyme_4_Number_of_Residues:
1055

# Metabolic_Enzyme_4_Molecular_Weight:
117494

# Metabolic_Enzyme_4_Theoretical_pI:
6.51

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein-tyrosine kinase activity
Function:  transmembrane receptor protein tyrosine kinase activity
Function:  ephrin receptor activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  enzyme linked receptor protein signaling pathway
Process:  transmembrane receptor protein tyrosine kinase signaling pathway
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  protein amino acid phosphorylation
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Receptor for members of the ephrin-B family

# Metabolic_Enzyme_4_Pathway:
Not Available

# Metabolic_Enzyme_4_Reaction:
Not Available

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01404:Ephrin_lbd;
PF00041:fn3;
PF07714:Pkinase_Tyr;
PF00536:SAM_1

# Metabolic_Enzyme_4_Signals:
1-18

# Metabolic_Enzyme_4_Transmembrane_Regions:
544-564

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.10.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
495678

# Metabolic_Enzyme_4_SwissProt_ID:
EPHB2_HUMAN (P29323)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
EPHB2

# Metabolic_Enzyme_4_Geneatlas_id:
EPHB2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:3393

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Membrane; single-pass type I membrane protein

# Metabolic_Enzyme_4_Gene_Sequence:
>2946 bp
ATGTGGGTTCCAGTCCTAGCCCTGCCTGTGTGCACTTATGCAGAAACGCTAATGGACTCC
ACTACAGCGACTGCTGAGCTGGGCTGGATGGTGCATCCTCCATCAGGGTGGGAAGAGGTG
AGTGGCTACGATGAGAACATGAACACGATCCGCACGTACCAGGTGTGCAACGTGTTTGAG
TCAAGCCAGAACAACTGGCTACGGACCAAGTTTATCCGGCGCCGTGGCGCCCACCGCATC
CACGTGGAGATGAAGTTTTCGGTGCGTGACTGCAGCAGCATCCCCAGCGTGCCTGGCTCC
TGCAAGGAGACCTTCAACCTCTATTACTATGAGGCTGACTTTGACTCGGCCACCAAGACC
TTCCCCAACTGGATGGAGAATCCATGGGTGAAGGTGGATACCATTGCAGCCGACGAGAGC
TTCTCCCAGGTGGACCTGGGTGACCGCGTCATGAAAATCAACACCGAGGTGCGGAGCTTC
GGACCTGTGTCCCGCAGCGGCTTCTACCTGGCCTTCCAGGACTATGGCGGCTGCATGTCC
CTCATCGCCGTGCGTGTCTTCTACCGCAAGTGCCCCCGCATCATCCAGAATGGCGCCATC
TTCCAGGAAACCCTGTCGGGGGCTGAGAGCACATCGCTGGTGGCTGCCCGGGGCAGCTGC
ATCGCCAATGCGGAAGAGGTGGATGTACCCATCAAGCTCTACTGTAACGGGGACGGCGAG
TGGCTGGTGCCCATCGGGCGCTGCATGTGCAAAGCAGGCTTCGAGGCCGTTGAGAATGGC
ACCGTCTGCCGAGGTTGTCCATCTGGGACTTTCAAGGCCAACCAAGGGGATGAGGCCTGT
ACCCACTGTCCCATCAACAGCCGGACCACTTCTGAAGGGGCCACCAACTGTGTCTGCCGC
AATGGCTACTACAGAGCAGACCTGGACCCCCTGGACATGCCCTGCACAACCATCCCCTCC
GCGCCCCAGGCTGTGATTTCCAGTGTCAATGAGACCTCCCTCATGCTGGAGTGGACCCCT
CCCCGCGACTCCGGAGGCCGAGAGGACCTCGTCTACAACATCATCTGCAAGAGCTGTGGC
TCGGGCCGGGGTGCCTGCACCCGCTGCGGGGACAATGTACAGTACGCACCACGCCAGCTA
GGCCTGACCGAGCCACGCATTTACATCAGTGACCTGCTGGCCCACACCCAGTACACCTTC
GAGATCCAGGCTGTGAACGGCGTTACTGACCAGAGCCCCTTCTCGCCTCAGTTCGCCTCT
GTGAACATCACCACCAACCAGGCAGCTCCATCGGCAGTGTCCATCATGCATCAGGTGAGC
CGCACCGTGGACAGCATTACCCTGTCGTGGTCCCAGCCAGACCAGCCCAATGGCGTGATC
CTGGACTATGAGCTGCAGTACTATGAGAAGCAGGAGCTCAGTGAGTACAACGCCACAGCC
ATAAAAAGCCCCACCAACACGGTCACCGTGCAGGGCCTCAAAGCCGGCGCCATCTATGTC
TTCCAGGTGCGGGCACGCACCGTGGCAGGCTACGGGCGCTACAGCGGCAAGATGTACTTC
CAGACCATGACAGAAGCCGATTACCAGACAAGCATCCAGGAGAAGTTGCCACTCATCATC
GGCTCCTCGGCCGCTGGCCTGGTCTTCCTCATTGCTGTGGTTGTCATCGCCATCGTGTGT
AACAGACGGGGGTTTGAGCGTGCTGACTCGGAGTACACGGACAAGCTGCAACACTACACC
AGTGGCCACATGACCCCAGGCATGAAGATCTACATCGATCCTTTCACCTACGAGGACCCC
AACGAGGCAGTGCGGGAGTTTGCCAAGGAAATTGACATCTCCTGTGTCAAAATTGAGCAG
GTGATCGGAGCAGGGGAGTTTGGCGAGGTCTGCAGTGGCCACCTGAAGCTGCCAGGCAAG
AGAGAGATCTTTGTGGCCATCAAGACGCTCAAGTCGGGCTACACGGAGAAGCAGCGCCGG
GACTTCCTGAGCGAAGCCTCCATCATGGGCCAGTTCGACCATCCCAACGTCATCCACCTG
GAGGGTGTCGTGACCAAGAGCACACCTGTGATGATCATCACCGAGTTCATGGAGAATGGC
TCCCTGGACTCCTTTCTCCGGCAAAACGATGGGCAGTTCACAGTCATCCAGCTGGTGGGC
ATGCTTCGGGGCATCGCAGCTGGCATGAAGTACCTGGCAGACATGAACTATGTTCACCGT
GACCTGGCTGCCCGCAACATCCTCGTCAACAGCAACCTGGTCTGCAAGGTGTCGGACTTT
GGGCTCTCACGCTTTCTAGAGGACGATACCTCAGACCCCACCTACACCAGTGCCCTGGGC
GGAAAGATCCCCATCCGCTGGACAGCCCCGGAAGCCATCCAGTACCGGAAGTTCACCTCG
GCCAGTGATGTGTGGAGCTACGGCATTGTCATGTGGGAGGTGATGTCCTATGGGGAGCGG
CCCTACTGGGACATGACCAACCAGGATGTAATCAATGCCATTGAGCAGGACTATCGGCTG
CCACCGCCCATGGACTGCCCAGCTGCCCTGCACCAACTCATGCTGGACTGTTGGCAGAAG
GACCGCAACCACCGGCCCAAGTTCGGCCAAATTGTCAACACGCTAGACAAGATGATCCGC
AATCCCAACAGCCTCAAAGCCATGGCGCCCCTCTCCTCTGGCATCAACCTGCCGCTGCTG
GACCGCACGATCCCCGACTACACCAGCTTTAACACGGTGGACGAGTGGCTGAAGGCCATC
AAGATGGGGCAGTACAAGGAGAGCTTCGCCAATGCCGGCTTCACCTCCTTTGACGTCGTG
TCTCAGATGATGATGGAGGACATTCTCCGGGTTGGGGTCACTTTGGCTGGCCACCAGAAA
AAAATCCTGAACAGTATCCAGGTGATGCGGGCGCAGATGAACCAGATTCAGTCTGTGGAG
GTTTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
D31661

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_4_Locus:
1p36.1-p35

# Metabolic_Enzyme_4_SNPs:
rs35882952; rs36069879; rs309472; rs2295022; rs2229871; rs1982227; rs1561624; rs751022; rs2222111; rs309473; rs908503; rs2176273; rs882025; rs10753547; rs2165331; rs2817885; rs10917300; rs10917288; rs2817904; rs4612601; rs6426770; rs6426766; rs6703896; rs2817881; rs10917284; rs7521936; rs10917317; rs1318720; rs876685; rs6673115; rs963113; rs7536195; rs6426771; rs2582021; rs10799760; rs6670405; rs309479; rs1465889; rs6659914; rs6660612; rs4654814; rs2817903; rs1561625; rs6662622; rs6695566; rs6698922; rs6701399; rs10799764; rs2817907; rs893966; rs751024; rs309485; rs10753541; rs2817900; rs10799770; rs309499; rs2582022; rs116119; rs10917323; rs4655135; rs4654824; rs935039; rs10753545; rs893960; rs4655097; rs10799761; rs7530478; rs4233292; rs873296; rs10753539; rs12407525; rs4655107; rs4655128; rs6687094; rs3935109; rs7519206; rs893961; rs4655130; rs2817896; rs10799765; rs10917312; rs750012; rs6672700; rs4654819; rs2817901; rs10799769; rs7554093; rs4361967; rs4263970; rs7528104; rs6426763; rs7541752; rs751023; rs7413155; rs2165332; rs11578621; rs4655131; rs294231; rs2817876; rs10917283; rs882024; rs309475; rs2986657; rs10917325; rs10799766; rs893964; rs11803370; rs4654815; rs1561628; rs12043268; rs10917307; rs6667289; rs12562997; rs4655114; rs12028458; rs4654820; rs10733034; rs4506436; rs2869513; rs7340102; rs12410872; rs2138542; rs10465543; rs1516526; rs10917314; rs4655093; rs309480; rs6655962; rs12074571; rs309482; rs6683698; rs2119319; rs7535750; rs177927; rs10799771; rs6661718; rs4390147; rs4655123; rs4654818; rs893969; rs2904122; rs10799772; rs12076863; rs2582032; rs10442639; rs12076351; rs6664696; rs4347183; rs6687487; rs309503; rs309486; rs11808976; rs7521813; rs2817909; rs6695066; rs2675494; rs2817882; rs12131925; rs4655120; rs10917285; rs16827697; rs12090415; rs10917324; rs4654821; rs4655134; rs2817893; rs12723359; rs6426769; rs6694899; rs4654823; rs11807221; rs1122210; rs1866792; rs7516175; rs2582036; rs6426764; rs12723691; rs12404289; rs17488885; rs4655094; rs7549224; rs734445; rs2119320; rs6664926; rs12061624; rs12401695; rs12724658; rs893962; rs6426772; rs11801544; rs12410054; rs12045966; rs10917281; rs6700141; rs1866790; rs12410046; rs12033902; rs2817902; rs1010948; rs2869511; rs10917305; rs2817872; rs1440576; rs11811221; rs309502; rs6667416; rs4654817; rs12566963; rs16827672; rs1554211; rs10799759; rs2869512; rs309501; rs2043970; rs908502; rs4600017; rs10753544; rs4655121; rs11579491; rs1561622; rs6675651; rs4147362; rs6686970; rs4655100; rs11800828; rs4601555; rs309476; rs6426768; rs10917320; rs10917318; rs2043969; rs1866797; rs2582018; rs1440577; rs2176274; rs16827555; rs4654825; rs309500; rs2817912; rs6686906; rs893968; rs4654826; rs4503323; rs4291474; rs10799763; rs309497; rs12564658; rs16827678; rs1010011; rs16827699; rs4655111; rs4655117; rs4655099; rs16827484; rs6426767; rs4655136; rs2765852; rs10465531; rs6692683; rs309481; rs4655129; rs309488; rs17435718; rs2817913; rs6688933; rs4073886; rs11802208; rs2218194; rs309498; rs309504; rs17436065; rs16827686; rs309478; rs2582033; rs1002434; rs6685431; rs2582020; rs2746331; rs12746324; rs10732280; rs1440578; rs2817914; rs908500; rs4655133; rs6668788; rs4655105; rs10737467; rs10917313; rs309487; rs6426762; rs12405683; rs2582026; rs16827666; rs4297260; rs6700664; rs309543; rs10157808; rs4655132; rs6697530; rs4233294; rs11801383; rs991409; rs4654822; rs6700554; rs6658894; rs4655095; rs12730142; rs6675629; rs12239985; rs6426765; rs6703663; rs7541869; rs1866794; rs12730147; rs2817910; rs2817898; rs2765854; rs11589153; rs4655104; rs4655127; rs16827635; rs3122405; rs4589082; rs17435615; rs12093721; rs12143574; rs309495; rs3738296; rs10917322; rs10753546; rs4655101; rs12408248; rs170129; rs12039391; rs17488348; rs10917327; rs4233295; rs10917290; rs10917297; rs16827638; rs11581239; rs3935110; rs11585659; rs12411186; rs17436434; rs2165330; rs6689771; rs11587921; rs7546953; rs4655113; rs12133964; rs11589563; rs16827504; rs6697737; rs2176272; rs10917304; rs12086772; rs2817874; rs2817886; rs2582016; rs10917296; rs10917321; rs7521053; rs2582019; rs10917289; rs10917282; rs12049176; rs2203609; rs12131718; rs10753540; rs2675493; rs10799768; rs7545588; rs11802220; rs4655124; rs309471; rs16827538; rs12074138; rs2817887; rs2582035; rs6666706; rs1866791; rs16827646; rs10917319; rs4655119; rs309474; rs2817889; rs16827709; rs4655109; rs16827692; rs10799762; rs12731889; rs12062524; rs4610978; rs2746332; rs2582023; rs10917308; rs11576929; rs309464; rs12027585; rs16827653; rs4233296; rs4655110; rs1561627; rs12074315; rs4655125; rs4655098; rs12043267; rs10917306; rs4655102; rs10158095; rs2817888; rs12085307; rs10917287; rs10917280; rs12408669; rs7517616; rs6689527; rs309484; rs3934847; rs4427376; rs2817905; rs172417; rs10917295; rs6693330; rs12732926; rs6658621; rs4654816; rs12402508; rs6663298; rs4655106; rs7540682; rs1467416; rs12116772; rs10917286; rs4655108; rs908501; rs17487259; rs10753543; rs172635; rs16827476; rs6682233; rs4233293; rs16827502; rs12564000; rs2746336; rs10917309; rs7549431; rs4655103; rs12035865; rs6665618; rs10917299; rs309477; rs12062379; rs10917292; rs309465; rs2203608; rs309483; rs6679387; rs12562131; rs309505; rs6660673; rs2869056; rs294219; rs1054792; rs28936395; rs35847739; rs1371869; rs34273063; rs12083517; rs2675498; rs41266949; rs34626029; rs34608691; rs34306640; rs4654813; rs35500173; rs12746622; rs2493343; rs5773024; rs35435930; rs35842051; rs12731911; rs34657020; rs34763217; rs4644461; rs12749431; rs36212827; rs10917291; rs2493344; rs34345925; rs2817879; rs2817877; rs12751494; rs10799767; rs12039839; rs12064951; rs10917298; rs34123004; rs11581391; rs3971878; rs4488003; rs12141642; rs41266947; rs2817890; rs28649787; rs5773019; rs35001652; rs12027546; rs12723992; rs12730135; rs10442640; rs12567513; rs28445955; rs2582025; rs34057025; rs34956800; rs34765685; rs35802955; rs11351118; rs4654827; rs4655126; rs35231501; rs12125570; rs12751340; rs6669666; rs10599403; rs2817873; rs10917310; rs7529044; rs34217967; rs35864794; rs34240500; rs5773020; rs10667863; rs11272230; rs3971877; rs309468; rs11435992; rs36155921; rs4484898; rs12742143; rs12079256; rs35652771; rs28709833; rs34926160; rs35875853; rs34707209; rs35674202; rs34305335; rs10917303; rs9887784; rs1866796; rs2765853; rs10753542; rs28575426; rs12090702; rs5773015; rs12760811; rs2675496; rs35319777; rs12751344; rs34423675; rs35102609; rs12748866; rs34321396; rs34241415; rs4417035; rs12749670; rs35086321; rs2817878; rs34048979; rs10672820; rs12094975; rs893963; rs6699648; rs12755288; rs12142672; rs11338643; rs12746926; rs920483; rs12061829; rs35994351; rs34708969; rs4610979; rs34967134; rs5773025; rs10917293; rs7536952; rs2765849; rs34244599; rs10605593; rs2582027; rs12080301; rs28696733; rs35968324; rs35345582; rs12046210; rs35957296; rs34247144; rs12085654; rs35501059; rs309470; rs11433075; rs10917316; rs35244192; rs6661451; rs12066464; rs309467; rs12076355; rs1926233; rs12034943; rs12048514; rs12025232; rs12060512; rs41307781; rs34722490; rs12730314; rs2675497; rs35995262; rs36068535; rs12086938; rs12138477; rs12760781; rs28433939; rs1866795; rs35099386; rs34795220; rs28655115; rs35072143; rs35153237; rs5773016; rs2119318; rs35660411; rs2675495; rs2817897; rs33935213; rs12401904; rs2817911; rs1470136; rs7530437; rs35686583; rs34122990; rs6662444; rs10917294; rs16827649; rs4655096; rs12727687; rs34947049; rs12085264; rs34039353; rs35971603; rs35348742; rs11588572; rs33934364; rs4233291; rs3935111; rs34696131; rs7545400; rs2817883; rs34171889; rs6697948; rs34089016; rs35360906; rs35521278; rs10917315; rs34743995; rs2256554; rs2493341; rs5773014; rs11581431; rs9943047; rs12026627; rs35595257; rs12725821; rs35243071; rs34104306; rs35850344; rs28563955; rs2817908; rs2817875; rs35651467; rs893965; rs34633057; rs7514049; rs34101402; rs36090813; rs34886654; rs35189646; rs28493134; rs34809969; rs34809074; rs2165333; rs12116671; rs34582119; rs12409124; rs34790056; rs34009512; rs12731103; rs35800840; rs28536506; rs5773026; rs1561626; rs12068348; rs34093929; rs12730148; rs9659857; rs34659042; rs34987424; rs11579071; rs35816172; rs33977796; rs2817906; rs12065377; rs28420849; rs2083500; rs10583422; rs34735800; rs2817871; rs12562447; rs34300874; rs28538498; rs34715725; rs2582015; rs35711504; rs35203503; rs2817884; rs10711518; rs7524041; rs5773017; rs10917301; rs36050579; rs34699835; rs35994981; rs12070186; rs10583420; rs10917279; rs33973506; rs35329318; rs12760655; rs7515292; rs4654811; rs12730141; rs12751331; rs35445066; rs309466; rs35103352; rs2119317; rs968789; rs309496; rs1465890; rs12083803; rs34409047; rs12066569; rs35730992; rs2817892; rs34503312; rs12746187; rs5773022; rs35801029; rs12023962; rs34927145; rs41310408; rs4480326; rs11386948; rs3053666; rs10158017; rs12070853; rs34756320; rs34228242; rs35296875; rs12734389; rs12045243; rs35670137; rs35489986; rs7515300; rs34811855; rs12062913; rs12726813; rs6685103; rs35890332; rs34161880; rs10917326; rs28554002; rs35145214; rs874696; rs34942911; rs5773027; rs2493342; rs309469; rs12040097; rs34582528; rs10683795; rs12068351; rs35618079; rs12117711; rs10675382; rs2582034; rs35506920; rs28453916; rs34165268; rs12749566; rs12137587; rs12088757; rs2817880; rs6697383; rs34123232; rs36041857; rs4996341; rs5773018; rs34162616; rs12749445; rs35414054; rs12750256; rs11287437; rs34446692; rs10608016; rs5773023; rs4655122; rs10917302; rs2869057; rs34544278; rs12030428; rs10737468; rs10612497; rs12567110; rs28455953; rs34477804; rs35644005; rs6659910; rs35920905; rs35833273; rs12030616; rs36075209; rs35066330; rs12081762; rs34182895; rs2582024; rs34464314; rs2582028; rs6656394; rs2817891; rs7537713; rs12092809; rs309463; rs12120875; rs34062027; rs35358262; rs35219257; rs11361622; rs12747672; rs3032081; rs34956722; rs10917311; rs12409127; rs4654810; rs12045933; rs1866793; rs10442641; rs35606346; rs12066575; rs34256463; rs34500334; rs35046719; rs12744260; rs12759240; rs11420316; rs34902446; rs35262576; rs11800174; rs2675499; rs2817894; rs294217; rs294218; rs309490; rs309491; rs309492; rs309493; rs309494; rs309517; rs34957055; rs35520349; rs482273; rs6663671; rs6687402; rs744834; rs7520204; rs7555910

# Metabolic_Enzyme_4_General_References:
8589679; 9696046; 7898931; 7601466; 7688222; 1648701; 10508479; 9933164

# Metabolic_Enzyme_4_References:
12077486; 12535285; 15087176; 15111041

# Metabolic_Enzyme_5_ID:
7965

# Metabolic_Enzyme_5_Name:
Aldose reductase

# Metabolic_Enzyme_5_Synonyms:
AR; Aldehyde reductase

# Metabolic_Enzyme_5_Gene_Name:
AKR1B1

# Metabolic_Enzyme_5_Protein_Sequence:
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

# Metabolic_Enzyme_5_Number_of_Residues:
316

# Metabolic_Enzyme_5_Molecular_Weight:
35854

# Metabolic_Enzyme_5_Theoretical_pI:
6.99

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00051  Fructose and mannose metabolism;
 map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00620  Pyruvate metabolism

# Metabolic_Enzyme_5_Reaction:
alditol + NAD(P)+ = aldose + NAD(P)H + H+

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.1.1.21

# Metabolic_Enzyme_5_GenBank_ID_Protein:
178487

# Metabolic_Enzyme_5_SwissProt_ID:
ALDR_HUMAN (P15121)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AKR1B1

# Metabolic_Enzyme_5_Geneatlas_id:
AKR1B1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:381

# Metabolic_Enzyme_5_PDB_ID:
1T40

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
J04795

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_5_Locus:
7q35

# Metabolic_Enzyme_5_SNPs:
rs5054; rs5060; rs5059; rs2229543; rs3087630; rs5055; rs5053; rs1790999; rs1790998; rs1646640; rs4732027; rs2734653; rs3896278; rs2734650; rs10954455; rs1708432; rs10808275; rs17660462; rs2670227; rs11974100; rs2734657; rs2670232; rs1424426; rs2734649; rs2551472; rs2259458; rs17188118; rs12669537; rs2734655; rs7778371; rs1708434; rs11971263; rs2670230; rs10273906; rs17167854; rs2734665; rs969309; rs2701020; rs2734663; rs2734664; rs706207; rs759853; rs17167851; rs918825; rs918824; rs11975656; rs17856148; rs11544687; rs5057; rs4728325; rs5061; rs5062; rs5056; rs17849987; rs1803093; rs3210035; rs11544690; rs13306160; rs1803094; rs1803095; rs2852171; rs2854854; rs2551469; rs3749434; rs2734661; rs2670231; rs2551471; rs1791000; rs2670240; rs2734659; rs2852165; rs2551476; rs3216672; rs2854849; rs7801237; rs2269068; rs10588800; rs35880193; rs2734658; rs34559471; rs2691837; rs1732035; rs2852170; rs2854853; rs2670239; rs1646639; rs2854851; rs5058; rs2551470; rs2670233; rs13306159; rs2854848; rs2701019; rs2734660; rs1732037; rs2852164; rs11417418; rs35431624; rs2852163; rs2269069; rs35632302; rs2852173; rs2854850; rs2551473; rs35338055; rs2691840; rs2852172; rs2734652; rs2852167; rs2854852; rs6963238; rs1791006; rs34569487; rs2670229; rs2551475; rs2691838; rs13306161; rs3216673; rs2974975; rs2551474; rs34678793; rs2551467; rs33945153; rs2852169; rs2734656; rs2854846; rs2734651; rs2691839; rs2734662; rs2852166; rs2691841; rs2551468; rs2691835; rs2551477; rs2691836; rs13306162; rs1708427; rs2852168; rs2670226; rs1621922; rs2852174; rs2551465; rs2691845; rs2551466; rs918826; rs35706999; rs2852176; rs2691846; rs1708404; rs12532832; rs1732039; rs1646636; rs1646642; rs1646637; rs2852175; rs1646641; rs10228986; rs10236262; rs10236468; rs10241645; rs10244489; rs10252030; rs10263438; rs10275865; rs11973239; rs13225343; rs1708414; rs1708415; rs1708416; rs17167841; rs1722900; rs1722911; rs1732038; rs1791001; rs2347375; rs2670228; rs6977866; rs706206; rs7802421; rs782054

# Metabolic_Enzyme_5_General_References:
2498333; 2504709; 2510130; 2111143; 2112546; 1901857; 9195951; 8435445; 2492527; 8343525; 8281941; 8245005; 1621098; 1447221; 8234324; 9405046

# Metabolic_Enzyme_5_References:
10339620; 10733904; 11729242; 12482947

# Macromolecular_Interacting_Partner_1_ID:
5430

# Macromolecular_Interacting_Partner_1_Name:
Heme oxygenase 1

# Macromolecular_Interacting_Partner_1_Synonyms:
HO-1

# Macromolecular_Interacting_Partner_1_Gene_Name:
HMOX1

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Heme oxygenase 1
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
288

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
32819

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
8.68

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed

# Macromolecular_Interacting_Partner_1_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Macromolecular_Interacting_Partner_1_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF01126:Heme_oxygenase

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
265-287

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
EC 1.14.99.3

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
35173

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
HMOX1_HUMAN (P09601)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
HMOX1

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
HMOX1

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:5013

# Macromolecular_Interacting_Partner_1_PDB_ID:
1T5P

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Microsome

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>867 bp
ATGGAGCGTCCGCAACCCGACAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAGGCC
ACCAAGGAGGTGCACACCCAGGCAGAGAATGCTGAGTTCATGAGGAACTTTCAGAAGGGC
CAGGTGACCCGAGACGGCTTCAAGCTGGTGATGGCCTCCCTGTACCACATCTATGTGGCC
CTGGAGGAGGAGATTGAGCGCAACAAGGAGAGCCCAGTCTTCGCCCCTGTCTACTTCCCA
GAAGAGCTGCACCGCAAGGCTGCCCTGGAGCAGGACCTGGCCTTCTGGTACGGGCCCCGC
TGGCAGGAGGTCATCCCCTACACACCAGCCATGCAGCGCTATGTGAAGCGGCTCCACGAG
GTGGGGCGCACAGAGCCCGAGCTGCTGGTGGCCCACGCCTACACCCGCTACCTGGGTGAC
CTGTCTGGGGGCCAGGTGCTCAAAAAGATTGCCCAGAAAGCCCTGGACCTGCCCAGCTCT
GGCGAGGGCCTGGCCTTCTTCACCTTCCCCAACATTGCCAGTGCCACCAAGTTCAAGCAG
CTCTACCGCTCCCGCATGAACTCCCTGGAGATGACTCCCGCAGTCAGGCAGAGGGTGATA
GAAGAGGCCAAGACTGCGTTCCTGCTCAACATCCAGCTCTTTGAGGAGTTGCAGGAGCTG
CTGACCCATGACACCAAGGACCAGAGCCCCTCACGGGCACCAGGGCTTCGCCAGCGGGCC
AGCAACAAAGTGCAAGATTCTGCCCCCGTGGAGACTCCCAGAGGGAAGCCCCCACTCAAC
ACCCGCTCCCAGGCTCCGCTTCTCCGATGGGTCCTTACACTCAGCTTTCTGGTGGCGACA
GTTGCTGTAGGGCTTTATGCCATGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
X06985

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_1_Locus:
22q12|22q13.1

# Macromolecular_Interacting_Partner_1_SNPs:
rs2071747; rs9282702; rs5755713; rs11555832; rs9282701; rs8139532; rs8140370; rs5755720; rs5999815; rs8140669; rs11912889; rs6518952; rs9306300; rs5755719; rs3216831; rs9610292; rs5755718; rs2071748; rs17885185; rs5755717; rs2285112; rs5995100; rs2269533; rs11913097; rs5995099; rs17886055; rs16995662; rs5995097; rs7285877; rs2071749; rs2269534; rs17885522; rs12160711; rs17881086; rs5999816; rs17880614; rs2413346; rs4820192; rs8142390; rs17882597; rs17879082; rs5995098; rs9306301; rs5999814; rs9610291; rs9607267; rs5755716; rs17879606; rs11913209; rs17885902; rs17883018; rs5995101; rs9622194; rs17878790; rs17880294; rs17881147; rs17885925; rs2003038; rs17882565; rs2071746; rs9619536; rs3761439; rs17880288; rs12160039; rs17879895; rs5755712; rs17883752; rs9282700; rs35980144; rs11555830; rs11912348; rs17880056; rs5755721; rs36019273; rs35703925; rs36017314; rs35777199; rs5755715; rs17884268; rs13053677; rs17885296; rs12169444; rs12483783; rs17885538; rs28691814; rs9622192; rs12169485; rs35360540; rs17878771; rs34204969; rs35400739; rs13053402; rs9622193; rs17883936; rs34918147; rs34345283; rs17879027; rs9619539; rs9622191; rs10628026; rs12628401; rs17884230; rs34867836; rs13054865; rs13058638; rs17880184; rs5750104; rs36054326; rs35427263; rs9610290; rs3074372; rs35622428; rs9619534; rs35071398; rs5999811; rs5999813; rs5999810; rs9619537; rs9619535; rs34824930; rs13057211; rs5999812; rs17879594; rs12159977; rs1078979; rs12168789; rs12170872; rs2307334; rs2307335; rs2307337; rs3761438; rs4603883; rs4645726; rs4645729; rs4645731; rs4645741; rs4645742; rs4645746; rs4645747; rs5755722; rs5995096; rs5999817; rs5999819; rs713618; rs713688; rs713873; rs735266; rs735267; rs737777; rs743811; rs743813; rs743815; rs9306299; rs9619540

# Macromolecular_Interacting_Partner_1_General_References:
3345742; 10591208; 2911585; 2537723; 10467099

# Macromolecular_Interacting_Partner_1_References:
11368167

# Macromolecular_Interacting_Partner_2_ID:
6263

# Macromolecular_Interacting_Partner_2_Name:
Prostaglandin G/H synthase 2 precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II

# Macromolecular_Interacting_Partner_2_Gene_Name:
PTGS2

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prostaglandin G/H synthase 2 precursor
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPT
PNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNAD
YGYKSWEAFSNLSYYTRALPP
VPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQ
GSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGL
GHGVDLNHIYGETLARQRKLRLFKDGK
MKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGL
VPGLMMYATIWLREHN
RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPE
LLFNK
QFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQ
IAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMS
AELEALYGDIDAVELY
PALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKP
STFGGEVGFQIINTASIQSLICNNVKG
CPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
604

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
68997

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
7.41

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  antioxidant activity
Function:  peroxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity

# Macromolecular_Interacting_Partner_2_Pathway:
map00590  Prostaglandin and leukotriene metabolism

# Macromolecular_Interacting_Partner_2_Reaction:
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03098:An_peroxidase;
PF00008:EGF

# Macromolecular_Interacting_Partner_2_Signals:
1-17

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
EC 1.14.99.1

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
291988

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PGH2_HUMAN (P35354)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PTGS2

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PTGS2

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9605

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Microsome; microsomal membrane; peripheral membrane protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1815 bp

ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCC
TTGCTGTTCCC
ACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGT
ATAAGTGCGATTGTACCCGGAC
AGGATTCTATGGAGAAAACTGCTCAACACCGGAATTT
TTGACAAGAATAAAATTATTTCTGAAACCCACT
CCAAACACAGTGCACTACATACTTAC
CCACTTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCC
TTCGAAATGCAATTA
TGAGTTATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAA
TGCT
GACTATGGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTT
CCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCC
TGATTCAAATGAGATTG
TGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCC
AGGGCTCAAACATGATGTTTGCATTCTT
TGCCCAGCACTTCACGCATCAGTTTTTCAAG
ACAGATCATAAGCGAGGGCCAGCTTTCACCAACGGGCTG
GGCCATGGGGTGGACTTAAA
TCATATTTACGGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCA
AGGATGGAA
AAATGAAATATCAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGG
C
AGAGATGATCTACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAG
GTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAA
CAGAGTATGCGATGTGCTTAAAC
AGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCC
AGACAAGCAGGCTAATACTGATAGGAGAGACTAT
TAAGATTGTGATTGAAGATTATGTG
CAACACTTGAGTGGCTATCACTTCAAACTGAAATTTGACCCAGAA
CTACTTTTCAACAA
ACAATTCCAGTACCAAAATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGC
ATC
CCCTTCTGCCTGACACCTTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCT
ACAACAA
CTCTATATTGCTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGG
CAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATC
ACAGGCTTCCACTGACCAGAGCAGGCAGA
TGAAATACCAGTCTTTTAATGAGTACCGCA
AACGCTTTATGCTGAAGCCCTATGAATCATTTGAAGAACT
TACAGGAGAAAAGGAAATG
TCTGCAGAGTTGGAAGCACTCTATGGTGACATCGATGCTGTGGAGCTGTAT
CCTGCCCT
TCTGGTAGAAAAGCCTCGGCCAGATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGC
AC
CATTCTCCTTGAAAGGACTTATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGC
CAAGCACTTTTGG
TGGAGAAGTGGGTTTTCAAATCATCAACACTGCCTCAATTCAGTCT
CTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGA
GCTCATTAAAACAGTCACCATCAATGCAAGTTCTT
CCCGCTCCGGACTAGATGATATCA
ATCCCACAGTACTACTAAAAGAACGTTCGACTGAACTGTAG

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
L15326

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_2_Locus:
1q25.2-q25.3

# Macromolecular_Interacting_Partner_2_SNPs:
rs3218622; rs5272; rs5273; rs3218625; rs5279; rs5277; rs5278; rs5274; rs3218623; rs20429; rs4648265; rs5276; rs5275; rs2206593; rs4648292; rs689469; rs5271; rs3835508; rs689467; rs689470; rs689468; rs4648257; rs4648303; rs1051897; rs4648300; rs4648290; rs1051896; rs4648297; rs4648302; rs4648296; rs20432; rs2066826; rs4648268; rs4648287; rs20427; rs4648283; rs4648274; rs4648273; rs4648278; rs20430; rs4648284; rs20428; rs4648272; rs11567821; rs4648276; rs4648282; rs4648261; rs2745557; rs2066824; rs4648285; rs4648267; rs2066823; rs4648263; rs16825748; rs3218626; rs4648277; rs11567827; rs11567834; rs4648280; rs20434; rs2066822; rs4648271; rs4648262; rs4648258; rs16825745; rs20433; rs20424; rs4648306; rs20419; rs4648307; rs20415; rs4648308; rs689466; rs689465; rs20418; rs5270; rs4648251; rs4648256; rs4648304; rs4648310; rs20417; rs4648250; rs3918304; rs4648311; rs689462; rs20423; rs20420; rs2734779; rs11567815; rs11567831; rs11567814; rs4648309; rs20416; rs4648305; rs4648254; rs20426; rs4648279; rs4648264; rs4648288; rs3218624; rs3179567; rs4648295; rs36233646; rs3134592; rs3134591; rs4648299; rs4648298; rs13306032; rs11384450; rs11567830; rs13306038; rs3134589; rs13306033; rs2853804; rs3134590; rs2853805; rs11567829; rs11567819; rs4648289; rs4648301; rs13306035; rs34888870; rs4648294; rs13306031; rs4648293; rs2853803; rs4987012; rs12759220; rs11567822; rs4648260; rs4648269; rs11567826; rs13306034; rs4648259; rs11567820; rs4648266; rs11567825; rs4648281; rs11567824; rs11567823; rs4648286; rs4648270; rs4322189; rs35440347; rs11567835; rs689463; rs4648253; rs2223626; rs11567832; rs689464; rs20421; rs4648252; rs2745558; rs34901173; rs4648255; rs11567833; rs20422; rs11567837; rs11567836; rs12027712; rs10649972; rs10911902; rs10911905; rs10911907; rs10911908; rs1119064; rs1119065; rs11583191; rs12042763; rs12064238; rs12124257; rs12749248; rs2143416; rs2143417; rs2179555; rs2383515; rs2734776; rs2734777; rs2745559; rs4422959; rs6684912

# Macromolecular_Interacting_Partner_2_General_References:
8473346; 1380156; 8181472; 7945196

# Macromolecular_Interacting_Partner_2_References:
16282556; 8613062; 8764992

# Macromolecular_Interacting_Partner_3_ID:
7803

# Macromolecular_Interacting_Partner_3_Name:
Ciliary dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Synonyms:
Axonemal beta dynein heavy chain 8

# Macromolecular_Interacting_Partner_3_Gene_Name:
DNAH8

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Ciliary dynein heavy chain 8
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
4490

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
514670

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  motor activity
Function:  microtubule motor activity
Function:  ATPase activity
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleoside-triphosphatase activity
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  cell organization and biogenesis
Process:  organelle organization and biogenesis
Process:  cytoskeleton organization and biogenesis
Process:  microtubule-based process
Process:  microtubule-based movement
 ||
>>>
Component:  protein complex
Component:  microtubule associated complex
Component:  dynein complex

# Macromolecular_Interacting_Partner_3_General_Function:
Cell cycle control, cell division, chromosome partitioning 

# Macromolecular_Interacting_Partner_3_Specific_Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF07728:AAA_5;
PF08385:DHC_N1;
PF08393:DHC_N2;
PF03028:Dynein_heavy

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
14335444

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
DYH8_HUMAN (Q96JB1)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
DNAH8

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
DNAH8

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:2952

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>13473 bp
ATGATGAAATTGTATATAGACAATGCAGCCCCGGATAAACTAAAAGGACTGTGCATATTT
TTTGTTCGTTGCCGTAATGATGTTGCTATAAATGTTAAAACTATTCAAGAGGAAGCGCTC
TTTACTGTTCTGGATGCGTCGAAAGGACTCTTAAATGGAATTAGGGATATGTTGGCAAAT
ATATTTCTACCAGCTGTTCTTGCAACAAACAACTGGGGTGCTTTAAACCAGTCCAAGCAG
GGAGAATCTGAAAAACATATTTTCACTGAAACCATCAACAGATATCTTTCATTTTTAGAT
GGTGCTAGAATAAGTATTGAGGGAACAGTGAAGTTAAAGACAATAGACAATGTTAATTTT
TCCAAACTGCACACCTTTGAAGAAGTAACTGCTGCAGCCAGCAACTCAGAAACTGTTCAT
CAGCTGGAGGAAGTGCTGATGGTATGGTACAAACAGATCGAACAGGTACTTATTGAGAGT
GAGCAGATGAGAAAAGAAGCTGGTGATTCAGGTCCACTCACTGAATTGGAACACTGGAAA
CGCATGTCAGCCAAGTTCAACTATATCATTGAGCAGATTAAAGGGCCAAGTTGTAAGGCT
GTCATAAATGTGCTAAATGTTGCACACTCCAAACTGCTAAAGAATTGGCGTGATTTGGAT
GCAAGAATCACTGATACAGCAAATGAATCCAAAGATAATGTCAGATATTTGTATACTTTG
GAAAAAGTGTGTCAACCTCTCTATAACCATGACCTAGTTTCCATGGCACATGGAATACAA
AATTTGATTAATGCCATCAGAATGATTCACGGTGTGTCAAGGTATTATAATACCTCAGAG
AGAATGACCTCATTGTTTATCAAGGTAACAAATCAAATGGTAACAGCATGTAAAGCATAT
ATTACTGATGGAGGATTAAACCATGTATGGGATCAGGAAACGCCAGTTGTACTAAAGAAA
ATTCAGGACTGCATTTTTCTATTCAAGGAATATCAGGCATCTTTTCATAAAACAAGGAAA
CTGATTTCAGAATCCTCAGGGGAAAAATCTTTTGAGGTTTCAGAAATGTATATATTTGGA
AAATTTGAAGCTTTTTGCAAAAGACTGGAGAAGATTACAGAAATGATAACTGTTGTGCAA
ACATATTCAACCTTGAGTAATTCTACCATAGAAGGAATAGATATTATGGCAATAAAATTC
AGAAATATATACCAAGGGGTTAAGAAAAAGCAATATGACATTCTGGATCCAAGAAGGACA
GAATTTGACACAGATTTCTTAGATTTCATGACAAAAATCAATGGTTTAGAGGTACAAATA
CAGGCATTTATGAACAGTAGTTTTGGGAAAATCTTATCTTCTCAGCAGGCTCTTCAGCTA
CTTCAAAGGTTTCAGAAGCTGAACATTCCCTGTCTGGGATTAGAAATAAACCACACAATA
GAGCGTATTCTTCAGTACTATGTGGCTGAACTTGATGCTACTAAGAAGCTTTATCATTCT
CAGAAAGATGACCCCCCTCTTGCTCGCAACATGCCCCCTATAGCAGGAAAAATACTCTGG
GTGAGGCAGCTCTATCGCCGGATAAGTGAGCCCATCAATTATTTCTTTAAAAACTCAGAC
ATTTTATCAAGTCCGGACGGTAAAGCTGTCATCCGTCAGTATAACAAGATCTCCTATGTG
CTGGTGGAATTCGAGGTGGTCTATCACACAGCCTGGGTCAGAGAGATTTCACAGTTGCAT
TACGCTTTACAAGCCACGCTTTTTGTGCGACATCCAGAAACAGGGAAGTTGCTGGTTAAT
TTCGATCCCAAAATTTTGGAAGTTGTTCGGGAAACTAAGTGTATGATAAAAATGAAGTTG
GATGTACCAGAACAGGCAAAGAGATTGCTAAAATTGGAAAGTAAATTGAAAGCAGACAAA
CTGTATTTGCAGGGTCTTCTGCAATATTATGATGAGTTATGTCAGGAAGTGCCTTCTGTG
TTTGTCAATCTGATGACCCCAAAAATGAAAAAGGTGGAATCTGTGTTGAGGCAAGGACTC
ACAGTGTTAACATGGTCGTCTTTAACACTGGAAAGCTTCTTTCAAGAAGTCGAATTAGTT
TTGGATATGTTCAATCAACTTTTAAAGAAGATCAGTGACTTGTGTGAAATGCATATTGAT
ACAGTTCTGAAGGAGATAGCCAAAACTGTGTTGATTTCTCTGCCTGAAAGTGGTGCTACC
AAAGTAGAAGATATGTTGACCCTCAATGAGACATACACAAAAGAATGGGCTGACATTCTA
AACCACAAAAGTAAGCATGTGGAAGAAGCTGTCAGAGAACTTATATCAATATTTGAGCAG
ATTTATGAAGTGAAATACACTGGGAAAGTAGGAAAACAGTCAGAACAGCGGAAACACGTT
GTTTTTGGAAGTGAAACAGAAGAGGGTGAAAACAATGACTATGAAGCTAATATTGTGAAT
GAGTTTGATACTCATGATAAAGAAGATGAATTTAAAAAGGAGTGTAAAGAGGTCTTTGCT
TTTTTCTCTCATCAATTACTAGACAGTCTTCAAAAAGCTACACGGTTATCTCTGGACACA
ATGAAAAGAAGAATATTTGTTGCAAGCCTTTATGGGCGAAAGCAGTCAGAAGATATTATT
TCGTTTATAAAAAGTGAAGTACATCTTGCAATTCCTAATGTGGTGATGATTCCTAGTTTG
GATGACATTCAACAAGCCATTAACCGTATGATCCAGTTAACCCTGGAGGTCAGCAGAGGA
GTGGCTCACTGGGGGCAACAGCAAATCCGTCCCATCAAGTCTGTCATTCCCAGCCCCACC
ACTACTGACGTGACCCATCAAAACACAGGAAAACTGCTGAAGAAGGAAGAAAGATCTTTT
GAAGAAGCTATTCCTGCGAGGAAGCTGAAGAATTTTTACCCGGGGGTAGCGGAGCACAAG
GATATTTCTAAGTTGGTCCTGCTCCTTTCTTCCTCTGTAAATTCCCTAAGAAAGGCAGCT
CATGAGGCCCTGCAGGACTTTCAGAAGTACAAGACTCTCTGGACAGAGGACCGCGATGTG
AAAGTGAAGGAATTTTTGGCTAACAACCCCTCTCTGACTGAAATCAGATCAGAAATTCTA
CACTATGCTACTTTTGAACAGGAGATTGATGAGTTGAAGCCTATTATTGTTGTAGGAGCA
CTTGAATTACATACAGAGCCGATGAAATTGGCCTTATCCATCGAGGCCAAGGCATGGAAG
ATGTTACTCTGTCGATATCTGAATGAAGAATACAAAAAGAAAATGTCATACATGATAGCA
TTTATTAATGAATACTTGAAAAAGTTATCTAGACCTATTCGTGATTTAGATGATGTCAGA
TTTGCAATGGAAGCCTTGTCTTGCATACGTGATAATGAAATTCAAATGGACATGACTTTG
GGACCAATTGAAGAAGCCTATGCTATTTTAAACAGATTTGAAGTTGAAGTAACCAAAGAA
GAATCAGAAGCAGTTGATACCTTAAGATATTCTTTCAACAAATTGCAGAGCAAAGCTGTT
TCAGTACAAGAGGACCTAGTTCAAGTGCAGCCAAAGTTTAAAAGCAATCTACTTGAGTCT
GTGAAAGTTTTTCGTGAGGACGTGATAAACTTTGCAGAAGCATATGAATTGGAAGGACCT
ATGGTTCCAAATATACCACCCCAAGAAGCTAGCAACAGGCTACAGATATTTCAGGCCAGT
TTCGATGATCTGTGGAGGAAATTTGTTACGTATTCATCTGGTGAACAACTTTTTGGATTG
CCTGTGACTGATTATGAGGTTTTACACAAAACCAGAAAAGAACTCAACTTGCTGCAGAAG
CTGTATGGATTGTATGACACCGTAATGAGCAGTATTAGTGGTTATTATGAAATACTTTGG
GGAGATGTAGATATTGAAAAAATTAATGCAGAACTGCTGGAATTTCAAAACAGATGTCGT
AAACTTCCAAAAGGACTTAAAGATTGGCAAGCTTTTTTGGATCTCAAAAAGAGAATTGAT
GATTTCAGTGAGTCATGTCCTCTACTGGAAATGATGACCAATAAGGCCATGAAACAGAGA
CACTGGGATAGAATCTCCGAGTTAACTGGAACCCCATTTGATGTGGAATCTGATTCTTTT
TGCCTTAGAAATATCATGGAAGCACCACTCCTTAAACATAAGGATGATATTGAGGATATT
TGCATATCTGCCATTAAGGAGAAGGATATCGAAGCCAAGCTGACTCAGGTGATTGAGAAT
TGGACCAACCAAAATCTGAGTTTTGCAGCATTTAAGGGAAAAGGAGAGCTCCTGCTCAAA
GGAACCGAATCGGGAGAAATTATCACTTTGATGGAGGATAGTTTAATGGTCTTAGGGTCT
TTACTCAGCAACAGATACAATGCTCCATTTAAAAAAAATATCCAGAATTGGGTGTATAAA
TTGTCCACTTCCTCAGATATAATTGAAGAGTGGCTCGTAGTACAGAACCTTTGGGTTTAT
CTTGAAGCCGTCTTTGTAGGTGGAGATATTGCCAAACAGCTGCCTCAGGAAGCAAAACGT
TTTCAGAATATTGACAAGTCTTGGATAAAAATAATGCAGCGAGCTCATGAGAATCCCAAT
GTGATTAATTGCTGTGTTGGAGATGAAACCATGGGACAACTTTTACCTCATTTACATGAG
CAGTTGGAAGTATGTCAGAAGTCACTCACAGGGTATTTGGAGAAGAAACGATTACTGTTT
CCAAGATTCTTCTTTGTATCTGATCCAGTTCTCCTGGAAATTCTTGGACAAGCCAGTGAT
TCCCACACCATACAGCCACATCTCCCTGCAGTATCTGACAACATCAATGAGGTGACATTT
CATACAAAAGACTATGATCGCATCATGGCCGTCATATCAAGAGAAGGAGAAAAAATTGTT
TTGGATAATTCTGTTATGGCCAAAGGTCCTGTGGAGATTTGGCTACTGGATTTGTTAAAA
ATGCAGATGTCATCATTACATAATATAATTAGATCCGCTTTCTATCAAATCAGTGATTCA
GGATTTCAACTCTTACCATTCCTCAGCCACTTTCCAGCACAGGTTGGACTTCTGGGAATT
CAGATGTTGTGGACACACGATTCAGAAGAGGCTTTACGTAATGCAAAAGATGACAGGAAA
ATCATGCAAGTGACCAATCAGAAATTTTTGGATATTCTAAATACTCTCATTAGTCAGACA
ACACATGATCTAAGCAAGTTTGATAGAGTGAAGTTCGAGACTCTAATTACCATCCATGTG
CATCAGAGAGATATTTTTGATGACTTGGTAAAAATGCATATCAAATCACCTACTGACTTT
GAATGGCTAAAACAGAGTAGATTTTATTTTAAGGAAGATTTGGATCAAACTGTGGTGTCT
ATTACAGATGTTGATTTTATTTACCAAAATGAATTTCTGGGATGTACTGATCGTCTTGTT
ATCACTCCATTAACAGATAGATGCTATATCACGTTAGCTCAGGCCTTGGGCATGAACATG
GGAGGTGCTCCCGCAGGACCTGCTGGCACTGGCAAAACAGAAACCACAAAAGACATGGGA
AGGTGTTTGGGAAAATATGTGGTCGTGTTCAATTGCTCAGATCAAATGGATTTCAGAGGC
CTAGGAAGGATTTTCAAAGGTCTTGCACAGTCGGGTTCCTGGGGCTGTTTTGATGAGTTT
AACAGAATTGAATTGCCTGTATTATCAGTGGCAGCACAACAAATTTATATTGTTTTGACA
GCAAGAAAAGAAAGAAAGAAACAGTTCATTTTTTCTGATGGTGATTGTGTTGATTTAAAT
CCAGAATTTGGAATCTTCTTAACGATGAACCCTGGATATGCTGGGCGCCAGGAACTACCA
GAAAACCTAAAAATCCAGTTTAGAACTGTTGCTATGATGGTTCCTGATAGACAGATCATT
ATGAGAGTTAAACTTGCAAGCTGTGGTTTTCTTGAAAATGTTATCTTGGCTCAAAAATTT
TACGTTCTTTACAAACTCTGTGAAGAGCAACTTACTAAACAGGTTCATTATGACTTTGGA
TTGAGAAATATTCTGTCTGTATTGAGGACTCTTGGATCTCAAAAAAGAGCCAGACCAGAA
GATAGTGAATTAAGCATTGTCATGAGAGGACTAAGAGATATGAACCTTTCCAAACTGGTT
GATGAAGATGAACCCCTGTTCCTCAGCTTAATCAATGACCTGTTCCCAGGACTGCAACTG
GATAGTAATACTTATGCAGAACTGCAAAACGCAGTAGCCCATCAGGTTCAGATAGAGGGT
TTGATTAACCATCCACCCTGGAACCTGAAACTCGTGCAGTTATATGAGACGTCTTTGGTA
CGGCATGGCTTGATGACTCTTGGGCCCAGTGGTTCTGGAAAGACAACCGTTATCACGATT
CTAATGAAGGCGCAAACAGAATGCGGAAGGCCTCATAGAGAAATGCGAATGAATCCAAAA
GCCATTACTGCACCTCAGATGTTTGGCAGACTGGACACTGCTACCAATGACTGGACAGAT
GGGATTTTTTCTACTCTGTGGAGAAAAACATTAAAAGCTAAAAAAGGTGAAAACATTTTC
CTCATTTTAGATGGTCCTGTGGATGCCATCTGGATTGAGAACTTAAATTCCGTTTTGGAT
GACAATAAAACTCTGACGTTAGCTAATGGAGATCGCATTCCCATGGCCCCTAGTTGTAAG
CTTCTGTTTGAAGTCCACAATATCGAGAACGCCTCTCCTGCCACGGTTTCTAGGATGGGC
ATGGTCTATATCAGCAGCTCTGCTCTCAGCTGGAGGCCAATCTTACAGGCATGGTTGAAG
AAACGCACTGCACAGGAAGCTGCTGTATTCCTGACACTGTATGAGAAAGTCTTTGAAGAT
ACATACACATATATGAAACTAAATCTCAATCCCAAAATGCAGCTCTTGGAGTGCAACTAT
ATTGTGCAATCTCTCAATCTTCTGGAAGGGTTAATTCCCTCCAAAGAAGAAGGCGGTGTT
TCCTGTGTCGAACATCTTCATAAATTATTTGTGTTTGGCCTAATGTGGAGTTTAGGAGCC
CTTCTGGAATTAGAAAGCAGAGAAAAGCTTGAAGCCTTCTTACGGCAGCATGAAAGCAAG
TTGGACTTACCAGAAATACCTAAAGGCTCAAATCAAACCATGTATGAGTTTTATGTTACT
GATTATGGTGATTGGGAGCACTGGAATAAGAAACTTCAGCCTTATTATTATCCAACTGAC
AGTATTCCGGAATATTCATCAATTTTGGTTCCAAATGTTGACAATATTAGAACAAATTTT
TTGATAGACACCATTGCAAAACAACATAAAGCTGTTTTGCTCACAGGAGAGCAGGGAACT
GCAAAAACTGTCATGGTTAAGGCCTATTTGAAAAAATATGATCCTGAAGTACAGCTATCC
AAAAGTCTAAACTTTTCATCTGCCACAGAACCAATGATGTTTCAGAGAACAATTGAAAGC
TATGTGGATAAGCGAATTGGAAGCACATATGGGCCACCAGGAGGGAGAAAAATGACTGTA
TTTATTGATGATATTAATATGCCTGTGATTAATGAGTGGGGAGATCAGATAACTAATGAG
ATTGTGCGACAGATGATGGAAATGGAAGGAATGTACAGCTTGGACAAGCCTGGAGACTTC
ACTACTATTGTTGATGTGCAGCTCATAGCAGCAATGATCCACCCTGGAGGTGGTCGAAAT
GATATTCCACAACGTTTAAAAAGACAATTTACTGTGTTTAATTGTACATTGCCTTCAAAT
GCTTCAATAGACAAAATTTTTGGAATTATTGGATGTGGATACTTTGATCCTTGTAGAAGT
TTCAAGCCTCAAATATGTGAGATGATTGTGAATTTAGTCTCAGTGGGTAGAGTGCTGTGG
CAATGGACTAAGGTGAAGATGCTGCCAACTCCTTCTAAATTTCATTACATCTTCAATCTT
CGAGATCTTTCCAGAATTTGGCAAGGAATGTTGACCATAAAAGCTGAGGAGTGCGCTTCA
ATCCCTACTCTCCTGTCCCTTTTCAAACACGAGTGCAGCAGAGTAATTGCAGACAGATTT
ATAACTCCTGAAGATGAGCAGTGGTTTAATGCACATCTTACTCGTGCAGTTGAAGAAAAT
ATTGGCTCTGATGCAGCGTCGTGTATTCTTCCTGAACCATACTTTGTGGATTTTCTTCGT
GAGATGCCAGAACCAACTGGTGATGAACCTGAAGACTCTGTGTTTGAAGTACCCAAAATA
TATGAATTGATGCCATCCTTTGACTTTCTGGCTGAAAAACTCCAGTTTTACCAGAGACAG
TTCAATGAAATCATTAGAGGAACATCTCTTGATCTGGTGTTTTTTAAAGATGCAATGACT
CATCTTATTAAGATTTCACGAATAATTCGAACGTCGTGTGGAAATGCATTGCTGGTGGGT
GTTGGTGGTTCCGGAAAACAAAGTCTTTCAAGATTGGCCTCTTTTATTGCTGGCTATCAA
ATATTCCAGATAACATTAACCAGGTCTTACAATGTGACTAATCTAACAGATGATTTAAAA
GCTTTGTACAAAGTTGCTGGTGCTGATGGAAAAGGCATCACTTTCATCTTTACTGACAGT
GAAATAAAAGATGAGGCATTTCTAGAATACCTTAACAACTTGCTATCTTCAGGGGAGATC
TCCAACTTGTTTGCACGAGATGAGATGGATGAAATCACCCAAGGTCTGATTTCAGTGATG
AAGAGGGAGCTACCTCGCCATCCTCCTACCTTTGATAATTTGTATGAATACTTCATTTCA
AGATCAAGGAAGAACTTACATGTTGTTCTCTGCTTTTCTCCAGTTGGTGAGAAGTTCCGT
GCCCGTTCTTTGAAATTTCCTGGCTTGATATCAGGTTGCACTATGGACTGGTTCAGCCGC
TGGCCAAGGGAGGCTCTGATTGCTGTGGCCTCCTACTTCCTTTCAGACTATAATATTGTC
TGCTCTAGTGAAATTAAAAGACAAGTTGTAGAAACAATGGGCCTGTTTCATGACATGGTT
TCAGAGAGCTGTGAAAGTTATTTCCAAAGATACCGCCGAAGAGCACATGTGACTCCCAAA
TCTTACCTCTCATTTATAAATGGTTATAAAAACATTTATGCTGAAAAGGTGAAGTTCATT
AATGAACAGGCTGAACGTATGAATATTGGTCTTGATAAACTAATGGAGGCAAGTGAATCT
GTTGCTAAACTCTCTCAGGATCTTGCAGTCAAGGAGAAGGAGTTGGCAGTGGCTTCCATA
AAAGCAGACGAAGTATTAGCAGAAGTCACAGTAAGCGCTCAGGCTTCAGCCAAAATTAAA
AATGAAGTACAGGAGGTAAAGGACAAAGCCCAAAAAATTGTGGATGAAATTGATAGTGAA
AAAGTGAAAGCTGAAAGCAAGCTTGAGGCAGCTAAACCTGCACTGGAAGAAGCAGAAGCA
GCCCTGAATACTATCAAGCCAAATGATATTGCCACAGTCAGGAAACTTGCAAAACCACCA
CATCTTATTATGAGAATCATGGACTGTGTTCTGTTACTATTTCAAAAGAAAATTGACCCT
GTTACTATGGATCCAGAAAAATCTTGCTGTAAGCCATCATGGGGAGAGTCATTAAAGTTG
ATGAGTGCAACAGGATTCCTGTGGAGCCTTCAGCAGTTCCCTAAGGACACTATAAATGAA
GAGACTGTTGAGTTACTACAGCCATATTTTAATATGGATGATTATACTTTTGAAAGTGCC
AAAAAAGTCTGTGGGAATGTGGCTGGTCTCCTGTCTTGGACACTTGCTATGGCAATATTT
TATGGCATCAATAGAGAAGTGTTGCCTCTGAAGGCCAACCTGGCCAAGCAGGAAGGCCGG
TTAGCAGTTGCTAATGCTGAGTTAGGGAAGGCACAAGCCCTGCTGGATGAGAAGCAAGCT
GAGCTGGATAAAGTACAGGCAAAATTTGATGCAGCAATGAATGAGAAAATGGATTTGCTT
AATGACGCTGATACGTGCCGGAAAAAGATGCAGGCCGCCTCCACTCTCATCGATGGGCTG
AGTGGAGAAAAAATCCGGTGGACCCAGCAAAGTAAAGAATTCAAAGCTCAGATTAATAGA
CTTGTAGGTGATATTCTGCTGTGCACGGGATTCCTTTCCTACCTTGGTCCTTTCAATCAG
ATATTTAGGAACTATTTGCTTAAAGATCAATGGGAAATGGAGTTGAGAGCACGGAAAATT
CCTTTCACAGAAAACCTGAATCTTATTTCAATGTTGGTGGATCCTCCAACTATTGGTGAG
TGGGGGCTACAGGGATTACCAGGAGATGATCTCTCAATTCAGAATGGCATTATTGTGACA
AAGGCCACCAGATACCCACTCCTCATAGACCCACAAACTCAAGGCAAAACTTGGATTAAA
TCAAAGGAAAAAGAAAATGATTTACAGGTGACATCTCTGAACCGTAAATATTTTCGCACA
CACTTGGAGGACAGCCTTTCCTTGGGCCGACCCCTTCTCATTGAGGACATTCATGAAGAG
CTGGATCCAGCCTTGGATAATGTATTAGAAAAGAATTTTATTAAATCTGGCACCACTTTC
AAGGTGAAAGTCGGTGATAAGGAATGTGATATCATGGATACATTTAAACTTTACATTACT
ACGAAGTTACCAAATCCTGCCTTTACCCCAGAGATTAATGCTAAAACGTCAGTCATTGAT
TTCACTGTTACAATGAAAGGACTTGAGAATCAGTTACTAAGGAGAGTCATTCTAACAGAG
AAACAGGAGTTAGAGGCTGAGAGGGTTAAACTTTTGGAGGATGTTACTTTTAATAAGCGG
AAGATGAAAGAACTTGAAGATAACCTCCTCTATAAATTAAGTGCTACAAAAGGCTCATTG
GTAGATGACGAATCTCTCATTGGTGTACTTCGAACTACCAAGCAGACAGCAGCTGAGGTA
AGTGAAAAGTTGCATGTGGCTGCAGAAACTGAGATCAAGATCAACGCGGCTCAGGAGGAG
TTCCGGCCCGCAGCCACCCGCGGAAGCATCCTCTACTTCCTCATCACAGAGATGAGCATG
GTCAACATCATGTATCAGACGTCATTGGCCCAGTTCTTGAAGTTATTTGACCAGTCCATG
GCCAGATCTGAAAAGTCACCACTACCTCAAAAGAGAATTACAAATATTATCGAGTACCTG
ACATATGAAGTTTTTACATACTCTGTCAGAGGCCTATACGAAAACCACAAATTCCTGTTT
GTACTCCTCATGACCTTAAAGATTGACCTTCAGAGAGGGACAGTTAAGCACAGAGAGTTT
CAAGCTCTCATTAAAGGGGGAGCAGCTCTGGACCTGAAAGCCTGTCCTCCCAAACCCTAT
CGCTGGATCCTTGACATGACTTGGCTGAATCTTGTGGAGCTGAGTAAACTTCCACAATTT
GCAGAAATTATGAACCAGATATCTCGTAATGAGAAGGGGTGGAAAAGCTGGTTTGATAAA
GATGCTCCAGAGGAGGAAATTATCCCTGATGGATATAATGATTCACTAGATACCTGCCAT
AAACTTTTACTTATCAGGTCTTGGTGCCCAGACCGTACTGTTTTTCAAGCAAGAAAGTAT
ATTGCAGATTCTTTGGAGGAGAAGTACACAGAACCAGTTATCTTAAATCTGGAGAAAACT
TGGGAAGAAAGTGATACCCGGACACCTCTGATATGCTTCCTGTCCATGGGATCTGACCCC
ACCAATCAAATTGATGCATTGGCCAAGAAACTGAAACTGGAATGTAGAACTATCTCAATG
GGGCAAGGACAAGAAGTACATGCTCGAAAGCTGATTCAGATGTCAATGCAGCAGGGTGGT
TGGGTATTACTACAAAATTGCCACCTTGGCCTGGAATTCATGGAAGAATTACTAGAGACG
CTAATTACCACTGAAGCCAGTGATGATTCTTTCCGAGTATGGATAACTACGGAGCCCCAT
GATCGATTTCCAATTACATTGCTTCAGACCTCTCTCAAATTCACTAATGAGCCACCCCAA
GGTGTACGCGCAGGTTTGAAAAGAACATTTGCTGGAATTAATCAAGACCTTCTGGACATC
AGTAATTTACCCATGTGGAAGCCGATGCTTTACACAGTAGCATTTTTACACTCCACTGTG
CAGGAGCGACGAAAATTTGGCCCCTTAGGATGGAATATTCCCTACGAATTCAATTCTGCT
GACTTTTCAGCCAGTGTTCAGTTTATTCAGAATCACCTTGATGAATGCGATATTAAGAAA
GGTGTATCATGGAATACGGTTCGGTACATGATCGGAGAAGTACAATATGGAGACAGAGTG
ACAGATGACTTTGACAAACGTCTACTTAATTGCTTTGCCAGAGTCTGGTTCAGTGAGAAG
ATGTTTGAACCGTCATTCTGCTTTTATACTGGATATAAAATCCCCTTATGCAAAACCTTA
GACCAGTATTTTGAATACATCCAGTCACTGCCATCCCTAGATAACCCTGAAGTCTTTGGG
CTTCACCCTAATGCTGATATCACGTATCAGAGTAACACTGCTTCTGCTGTTCTTGAAACA
ATTACCAACATTCAACCCAAAGAGAGTGGAGGTGGTGTGGGAGAGACCCGGGAGGCTATT
GTTTATAGATTATCTGAAGATATGCTGAGTAAACTCCCTCCTGATTACATTCCTCATGAG
GTGAAATCTCGTTTGATAAAGATGGGCCATCTTAATTCAATGAACATATTTCTTAGACAA
GAAATTGACAGAATGCAAAGAGTCATTTCAGTACTCCGCAGTAGCCTGAGTGATCTAAAA
TTGGCCATTGAAGGAACAATCATTATGAGTGAGAATCTGAGAGATGCTCTGGACAACATG
TATGATGCTCGTATACCTCAGCTCTGGAAAAGAGTGTCTTGGGATTCGTCCACACTGGGC
TTCTGGTTCACTGAACTTTTGGAAAGAAATGCTCAGTTTTCTACGTGGATATTTGAAGGG
AGGCCTAATGTGTTTTGGATGACTGGTTTCTTTAATCCCCAAGGCTTCCTCACAGCAATG
AGGCAAGAAGTGACCCGTGCCCACAAAGGCTGGGCACTGGACACTGTGACCATCCACAAT
GAAGTTCTGAGACAGACCAAGGAGGAGATCACGTCACCCCCTGGGGAAGGTGTGTATATT
TATGGGCTCTACATGGATGGAGCAGCCTGGGACAGACGGAATGGGAAGCTCATGGAATCC
ACCCCCAAGGTACTCTTCACGCAGTTACCCGTGCTCCACATCTTTGCCATTAACTCCACG
GCACCCAAGGACCCCAAGCTGTATGTGTGTCCTATTTACAAGAAACCCAGGCGAACTGAT
TTGACCTTCATCACTGTGGTATATTTACGAACAGTGTTGTCCCCGGATCACTGGATCCTG
AGAGGAGTGGCCCTTTTGTGTGACATCAAGTAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF356519

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_3_Locus:
6p21.31-p21.1

# Macromolecular_Interacting_Partner_3_SNPs:
Not Available

# Macromolecular_Interacting_Partner_3_General_References:
12297094; 14574404; 9373155

# Macromolecular_Interacting_Partner_3_References:
12231402; 8181468

# Macromolecular_Interacting_Partner_4_ID:
8319

# Macromolecular_Interacting_Partner_4_Name:
Sodium- and chloride-dependent GABA transporter 1

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC6A1

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sodium and chloridedependent GABA transporter 1
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLALKGSLKQRIQVMVQPSEDTVRPENGPEHAQAGSSTSKEAYI

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
599

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
67015

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
8.16

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_4_Signals:
None

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
53-73
81-100
124-144
212-230
239-256
292-309
321-342
375-394
422-440
457-477
498-517
536-554

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
31658

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SC6A1_HUMAN (P30531)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC6A1

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC6A1

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:11042

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Cell membrane; multi-pass membrane protein. Membrane; multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1800 bp
ATGGCGACCAACGGCAGCAAGGTGGCCGACGGGCAGATCTCCACCGAGGTCAGCGAGGCC
CCTGTGGCCAATGACAAGCCCAAAACCTTGGTGGTCAAGGTGCAGAAGAAGGCGGCAGAC
CTCCCCGACCGGGACACGTGGAAGGGCCGCTTCGACTTCCTCATGTCCTGTGTGGGCTAT
GCCATCGGCCTGGGCAACGTCTGGAGGTTCCCCTATCTCTGCGGGAAAAATGGTGGGGGA
GCCTTCCTGATCCCCTATTTCCTGACACTCATCTTTGCGGGGGTCCCACTCTTCCTGCTG
GAGTGCTCCCTGGGCCAGTACACCTCCATCGGGGGGCTAGGGGTATGGAAGCTGGCTCCT
ATGTTCAAGGGCGTGGGCCTTGCGGCTGCTGTGCTATCATTCTGGCTGAACATCTACTAC
ATCGTCATCATCTCCTGGGCCATTTACTACCTGTACAACTCCTTCACCACGACACTGCCG
TGGAAACAGTGCGACAACCCCTGGAACACAGACCGCTGCTTCTCCAACTACAGCATGGTC
AACACTACCAACATGACCAGCGCTGTGGTGGAGTTCTGGGAGCGCAACATGCATCAGATG
ACGGACGGGCTGGATAAGCCAGGTCAGATCCGCTGGCCACTGGCCATCACGCTGGCCATC
GCCTGGATCCTTGTGTATTTCTGTATCTGGAAGGGTGTTGGCTGGACTGGAAAGGTGGTC
TACTTTTCAGCCACATACCCCTACATCATGCTGATCATCCTGTTCTTCCGTGGAGTGACG
CTGCCCGGGGCCAAGGAGGGCATCCTCTTCTACATCACACCCAACTTCCGCAAGCTGTCT
GACTCCGAGGTGTGGCTGGATGCGGCAACCCAGATCTTCTTCTCATACGGGCTGGGCCTG
GGGTCCCTGATCGCTCTCGGGAGCTACAACTCTTTCCACAACAATGTCTACAGGGACTCC
ATCATCGTCTGCTGCATCAATTCGTGCACCAGCATGTTCGCAGGATTCGTCATCTTCTCC
ATCGTGGGCTTCATGGCCCATGTCACCAAGAGGTCCATTGCTGATGTGGCCGCCTCAGGC
CCCGGGCTGGCGTTCCTGGCATACCCAGAGGCGGTGACCCAGCTGCCTATCTCCCCACTC
TGGGCCATCCTCTTCTTCTCCATGCTGTTGATGCTGGGCATTGACAGCCAGTTCTGCACT
GTGGAGGGCTTCATCACAGCCCTGGTGGATGAGTACCCCAGGCTCCTCCGCAACCGCAGA
GAGCTCTTCATTGCTGCTGTCTGCATCATCTCCTACCTGATCGGTCTCTCTAACATCACT
CAGGGGGGTATTTATGTCTTCAAACTCTTTGACTACTACTCTGCCAGTGGCATGAGCCTG
CTGTTCCTCGTGTTCTTTGAATGTGTCTCTATTTCCTGGTTTTACGGTGTCAACCGATTC
TATGACAATATCCAAGAGATGGTTGGATCCAGGCCCTGCATCTGGTGGAAACTCTGCTGG
TCTTTCTTCACACCAATCATTGTGGCGGGCGTGTTCATTTTCAGTGCTGTGCAGATGACG
CCACTCACCATGGGAAACTATGTTTTCCCCAAGTGGGGCCAGGGTGTGGGCTGGCTGATG
GCTCTGTCTTCCATGGTCCTCATCCCCGGGTACATGGCCTACATGTTCCTCGCCCTAAAG
GGCTCCCTGAAGCAGCGCATCCAAGTCATGGTCCAGCCCAGCGAAGACACTGTTCGCCCA
GAGAATGGTCCTGAGCACGCCCAGGCGGGCAGCTCCACCAGCAAGGAGGCCTACATCTAG


# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X54673

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:3

# Macromolecular_Interacting_Partner_4_Locus:
3p25-p24

# Macromolecular_Interacting_Partner_4_SNPs:
rs2272404; rs33948309; rs6344; rs2272401; rs6343; rs1710887; rs2928079; rs1710891; rs2933308; rs2930154; rs2675166; rs2944367; rs1710898; rs2675165; rs1568074; rs720352; rs1062246; rs1710892; rs1170695; rs6766999; rs9863701; rs2933309; rs9855272; rs1728816; rs9821726; rs6778281; rs1710897; rs1710890; rs6780165; rs1728817; rs1728814; rs4684055; rs2601126; rs1710880; rs6442218; rs2933310; rs2950800; rs2697149; rs6766512; rs11707097; rs9821288; rs1919075; rs1728811; rs4684054; rs3732944; rs2675161; rs2697144; rs2675160; rs7613535; rs11718132; rs9990174; rs17466478; rs1728815; rs1728807; rs11710097; rs6342; rs1170694; rs1710881; rs1710886; rs11710497; rs2930138; rs2697146; rs17466644; rs2697142; rs41276505; rs17033824; rs1617523; rs7629093; rs1170696; rs2675159; rs6789420; rs6804165; rs2944366; rs13320265; rs1710885; rs2697145; rs1728806; rs7645218; rs2944365; rs11919775; rs2933311; rs1568073; rs17601884; rs17033808; rs34189945; rs2697148; rs6766500; rs2697150; rs2601125; rs2933307; rs4038396; rs9879137; rs3817585; rs2697136; rs17532365; rs3856786; rs2697135; rs1028152; rs3856787; rs6780064; rs9821628; rs2246543; rs11925331; rs2950798; rs11719645; rs2272403; rs9876005; rs1728803; rs11708202; rs9310373; rs2272402; rs6770472; rs2675163; rs1728802; rs10510403; rs1710888; rs9836017; rs9822125; rs17033838; rs2928077; rs11712912; rs17033829; rs10514669; rs2928078; rs3774070; rs2675164; rs2697134; rs3817584; rs11711646; rs9819882; rs11290120; rs6341; rs12107996; rs3841958; rs2697138; rs7643585; rs1728818; rs2675156; rs2928080; rs2067382; rs2675157; rs1400154; rs2928081; rs17855574; rs1139554; rs17853248; rs35513423; rs34201135; rs2675167; rs2933313; rs35456709; rs10696522; rs11425810; rs34389160; rs13076117; rs35265541; rs41293373; rs7431276; rs10710996; rs35119915; rs35964686; rs2675158; rs2077135; rs1062616; rs11710192; rs1062237; rs11280487; rs1568072; rs34884581; rs6766948; rs2933312; rs34937975; rs11706135; rs7650969; rs1105781; rs41429044; rs5846691; rs11319908; rs34458709; rs2077136; rs35997142; rs11923810; rs34408917; rs2930155; rs2601124; rs11319907; rs35743928; rs35862296; rs34236722; rs2944364; rs2204689; rs34990229; rs2930137; rs35322516; rs28562799; rs41362845; rs10711832; rs2697147; rs2944363; rs11288671; rs35849758; rs17033816; rs41510044; rs41293365; rs34530325; rs41391147; rs9869358; rs41517144; rs41497953; rs41444444; rs41293369; rs41422847; rs41381549; rs2697140; rs41370144; rs35486441; rs41293371; rs41426745; rs3774069; rs35910232; rs34536989; rs10702772; rs2928076; rs34939196; rs2697141; rs9878778; rs34279235; rs41506145; rs9827626; rs41308232; rs10663120; rs41537851; rs35855996; rs41388950; rs6799755; rs9825337; rs9874325; rs2697139; rs41486951; rs35518745; rs34543552; rs41386254; rs41276503; rs35731717; rs1710882; rs41436650; rs1710889; rs35278682; rs41293367; rs41524646; rs41478447; rs2697137; rs41323844; rs35244184; rs9874479; rs10662859; rs41335049; rs35504380; rs35994749; rs41480248; rs41342644; rs34428600; rs34937215; rs35296635; rs1710873; rs41338544; rs41469948; rs2697151; rs13092196; rs12019231; rs34317261; rs10470635; rs11719708; rs12185978; rs12186082; rs1400155; rs1630696; rs1710874; rs1710875; rs1710876; rs1710877; rs1710878; rs1710879; rs1728819; rs1728820; rs1728821; rs17467186; rs1919076; rs2343224; rs2928082; rs2930151; rs2930152; rs36034065; rs4282038; rs4572751; rs4684752; rs6794616; rs6794626; rs7650199; rs9682960; rs9814213; rs9844030

# Macromolecular_Interacting_Partner_4_General_References:
2387399

# Macromolecular_Interacting_Partner_4_References:
11049839; 11070414; 11380820; 15248296

# Macromolecular_Interacting_Partner_5_ID:
8198

# Macromolecular_Interacting_Partner_5_Name:
Sodium- and chloride-dependent betaine transporter

# Macromolecular_Interacting_Partner_5_Synonyms:
Na(+/Cl(-betaine/GABA transporter; BGT-1

# Macromolecular_Interacting_Partner_5_Gene_Name:
SLC6A12

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Sodium and chloridedependent betaine transporter
MDGKVAVQEYGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
TREGLIAGEKETHL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
614

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
69429

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.25

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  neurotransmitter transporter activity
Function:  neurotransmitter:sodium symporter activity
Function:  transporter activity
Function:  organic acid transporter activity
Function:  organic acid:sodium symporter activity
Function:  sodium:amino acid symporter activity
Function:  gamma-aminobutyric acid:sodium symporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  neurotransmitter transport
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane
Component:  integral to plasma membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00209:SNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
45-65
73-92
117-137
211-229
238-255
291-308
320-341
374-393
423-441
458-478
499-518
538-556

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
881475

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
S6A12_HUMAN (P48065)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
SLC6A12

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
SLC6A12

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11045

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1845 bp
ATGGACGGGAAGGTGGCAGTGCAAGAGCGTGGGCCTCCTGCGGTCTCCTGGGTCCCCGAG
GAGGGAGAGAAGTTGGACCAGGAAGACGAGGACCAGGTGAAGGATCGGGGCCAATGGACC
AACAAGATGGAGTTTGTGCTGTCAGTGGCCGGGGAGATCATTGGGCTGGGCAATGTCTGG
AGGTTTCCCTATCTCTGCTACAAAAACGGAGGTGGAGCCTTCTTCATCCCCTACTTCATC
TTCTTCTTTGTCTGCGGCATCCCGGTGTTCTTCCTGGAGGTGGCGTTGGGCCAATACACC
AGCCAAGGGAGTGTCACAGCCTGGAGGAAGATCTGCCCCCTCTTCCAGGGCATTGGTCTG
GCATCTGTGGTCATCGAGTCATATTTGAATGTCTACTACATCATCATCCTTGCCTGGGCT
CTCTTCTACCTGTTCAGCTCCTTCACTTCTGAGCTGCCCTGGACGACCTGCAACAACTTT
TGGAACACAGAGCATTGCACGGACTTTCTGAACCACTCAGGAGCCGGCACAGTGACCCCA
TTTGAGAATTTTACCTCACCTGTCATGGAATTCTGGGAGAGACGAGTTCTGGGCATCACC
TCGGGCATCCATGACCTGGGCTCCCTGCGCTGGGAGCTGGCCCTGTGCCTCCTGCTCGCC
TGGGTCATCTGCTATTTCTGCATCTGGAAGGGGGTCAAGTCCACAGGCAAGGTGGTTTAT
TTCACAGCCACGTTTCCGTACCTGATGCTTGTCATTTTGCTGATCAGAGGTGTCACCCTT
CCCGGAGCCTACCAGGGCATCATCTACTACTTGAAGCCAGATTTGTTCCGCCTCAAGGAC
CCTCAGGTGTGGATGGATGCGGGCACCCAGATCTTCTTCTCCTTTGCCATCTGCCAGGGG
TGCCTGACAGCCCTGGGCAGCTACAACAAGTATCACAACAACTGCTACAAGGACTGCATC
GCCCTCTGCTTCCTGAACAGTGCCACCAGCTTTGTGGCTGGGTTTGTTGTCTTCTCCATC
CTGGGCTTCATGTCCCAAGAGCAAGGGGTGCCCATTTCTGAAGTGGCCGAGTCAGGTCCT
GGGCTGGCCTTCATCGCCTTCCCCAAGGCTGTGACTATGATGCCCTTATCCCAGCTGTGG
TCCTGCCTGTTCTTTATCATGCTCATATTCCTAGGGCTGGACAGCCAGTTTGTCTGTGTG
GAGTGCCTGGTGACAGCCTCCATAGACATGTTCCCCAGGCAGCTCCGGAAGAGCGGGCGG
CGCGAGCTCCTCATCCTCACCATCGCCGTCATGTGCTACCTGATAGGGCTTTTCCTGGTC
ACCGAGGGCGGGATGTACATCTTCCAGCTGTTTGACTACTATGCTTCCAGTGGCATATGC
CTGCTGTTCCTGTCATTGTTTGAAGTGGTCTGCATAAGCTGGGTGTATGGGGCGGACCGT
TTCTATGACAACATTGAGGACATGATTGGCTACCGGCCATGGCCCCTGGTGAAGATCTCC
TGGCTCTTCCTGACCCCTGGACTTTGCCTGGCCACTTTCCTCTTCTCCTTGAGCAAGTAC
ACCCCCCTCAAGTACAACAACGTCTATGTGTACCCGCCCTGGGGATACTCCATTGGCTGG
TTCCTGGCTCTGTCCTCCATGGTCTGTGTCCCACTCTTCGTCGTCATCACCCTCCTGAAG
ACTCGGGGTCCTTTCAGGAAGCGTCTGCGTCACGTCATCACCCCTGACTCCAGTCTGCCA
CAGCCCAAGCAACATCCCTGCTTGGATGGCAGTGCTGGCCGGAACTTTGGGCCCTCCCCA
ACAAGGGAAGGACTGATAGCCGGGGAGAAGGAGACCCATTTGTAG

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
U27699

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_5_Locus:
12p13

# Macromolecular_Interacting_Partner_5_SNPs:
rs557881; rs216250; rs526690; rs188610; rs542736; rs1051104; rs2075228; rs16928441; rs499368; rs10848574; rs529395; rs1051102; rs530510; rs3759373; rs546465; rs2284329; rs522993; rs2284328; rs4980866; rs216243; rs216245; rs2284330; rs2072536; rs216244; rs797743; rs557930; rs2300127; rs646569; rs9783494; rs216242; rs216246; rs533572; rs4980865; rs797745; rs2300125; rs12318158; rs216252; rs11061978; rs188609; rs7303106; rs11061976; rs216248; rs4980863; rs216251; rs10773978; rs216255; rs2284331; rs216239; rs7967868; rs10848531; rs216241; rs216247; rs7303400; rs2300126; rs518685; rs216249; rs12424772; rs515932; rs495655; rs510714; rs10848520; rs7312189; rs12422447; rs7312186; rs11061915; rs11609900; rs629311; rs7138605; rs34185038; rs34265203; rs2075229; rs7135457; rs34701255; rs4994258; rs12311166; rs12298213; rs632325; rs12425688; rs10582500; rs34233015; rs4994259; rs10161151; rs2270337; rs7295053; rs35911251; rs12319731; rs10128942; rs11061911; rs3214377; rs3837517; rs12821712; rs34964706; rs9783527; rs12318264; rs35653444; rs3741968; rs4994257; rs216254; rs33929668; rs12315451; rs35671377; rs9783496; rs12367240; rs7315381; rs216253; rs35756516; rs216240; rs12816769; rs11836552; rs11061873; rs4994256; rs12308180; rs567487; rs584973; rs12302339; rs35708012; rs34988534; rs7306657; rs34042024; rs509877; rs35042967; rs10848483; rs11062011; rs216226; rs2289954; rs3847948; rs3890993; rs478455; rs478520; rs481219; rs495360; rs500844; rs502783; rs505387; rs529198; rs533112; rs558406; rs559759; rs570680; rs633159; rs647001; rs649277; rs797738; rs797739

# Macromolecular_Interacting_Partner_5_General_References:
7589472; 7861179

# Macromolecular_Interacting_Partner_5_References:
10400634; 10524210; 11380820; 12527556

# Macromolecular_Interacting_Partner_6_ID:
8262

# Macromolecular_Interacting_Partner_6_Name:
Sodium/myo-inositol cotransporter

# Macromolecular_Interacting_Partner_6_Synonyms:
Na(+/myo-inositol cotransporter

# Macromolecular_Interacting_Partner_6_Gene_Name:
SLC5A3

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Sodium/myoinositol cotransporter
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVTIGASLFVSNI
GSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGH
RIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVA
VIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCN
VSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTL
MAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVP
VGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVV
ISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVL
GAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQ
IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQP
EDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDW
FCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
718

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
79695

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
7.30

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00474:SSF

# Macromolecular_Interacting_Partner_6_Signals:
1-24

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
46253612

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
SC5A3_HUMAN (P53794)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
SLC5A3

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
SLC5A3

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:11038

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2157 bp
ATGAGAGCTGTACTGGACACAGCAGACATTGCCATAGTGGCCCTGTATTTTATCCTGGTC
ATGTGCATTGGTTTTTTTGCCATGTGGAAATGTAATAGAAGCACCGTGAGTGGATACTTC
CTGGCGGGGCGCTCTATGACCTGGGTAGCAATTGGTGCCTCTCTGTTTGTGAGCAATATT
GGGAGTGAGCACTTCATTGGGCTGGCAGGATCTGGAGCTGCAAGTGGATTTGCAGTGGGC
GCATGGGAATTCAATGCCTTACTGCTTTTACAACTTCTGGGATGGGTTTTCATCCCAATT
TACATCCGGTCAGGGGTATATACCATGCCTGAATACTTGTCCAAGCGATTTGGTGGCCAT
AGGATTCAGGTCTATTTTGCAGCCTTGTCTCTGATTCTCTATATTTTCACCAAGCTCTCG
GTGGATCTGTATTCGGGTGCCCTTTTTATCCAGGAGTCTTTGGGTTGGAATCTTTATGTG
TCTGTCATCCTGCTCATTGGCATGACTGCTTTGCTGACTGTCACCGGAGGCCTTGTTGCA
GTGATCTACACAGACACTCTGCAGGCTCTGCTCATGATCATTGGGGCACTTACACTTATG
ATTATTAGCATAATGGAGATTGGCGGGTTTGAGGAAGTTAAGAGAAGGTACATGTTGGCC
TCACCCGATGTCACTTCCATCTTATTGACATACAACCTTTCCAACACAAATTCTTGTAAT
GTCTCCCCTAAGAAAGAAGCCCTGAAAATGCTGCGGAATCCAACAGATGAAGATGTTCCT
TGGCCTGGATTCATTCTTGGGCAGACCCCAGCTTCAGTATGGTACTGGTGTGCTGACCAA
GTCATCGTGCAGAGGGTCCTTGCAGCCAAAAACATTGCTCATGCCAAAGGCTCTACTCTT
ATGGCTGGCTTCTTAAAGCTCCTGCCAATGTTTATCATAGTTGTCCCAGGAATGATTTCC
AGGATACTGTTTACTGATGATATAGCTTGCATCAACCCAGAGCACTGCATGCTGGTGTGT
GGAAGCAGAGCTGGTTGCTCCAATATTGCTTACCCACGCCTGGTGATGAAGCTGGTTCCT
GTGGGCCTTCGGGGTTTAATGATGGCAGTGATGATTGCAGCTCTGATGAGTGACTTAGAC
TCTATCTTTAACAGTGCCAGTACCATATTCACCCTCGATGTGTACAAACTTATCCGCAAG
AGCGCAAGCTCCCGGGAGTTAATGATTGTGGGGAGGATATTTGTGGCATTTATGGTGGTG
ATCAGCATAGCATGGGTGCCAATCATCGTGGAGATGCAAGGAGGCCAGATGTACCTTTAC
ATTCAGGAGGTAGCAGATTACCTGACACCCCCAGTGGCAGCCTTGTTCCTGCTGGCAATT
TTCTGGAAGCGCTGCAATGAACAAGGGGCTTTCTATGGTGGAATGGCTGGCTTTGTTCTT
GGAGCAGTCCGTTTGATACTGGCCTTTGCCTACCGTGCCCCAGAATGTGACCAACCTGAT
AATAGGCCGGGCTTCATCAAAGACATCCATTATATGTATGTGGCCACAGGATTGTTTTGG
GTCACGGGACTCATTACTGTAATTGTGAGCCTTCTCACACCACCTCCCACAAAGGAACAG
ATTCGAACCACCACCTTTTGGTCTAAGAAGAACCTGGTGGTGAAGGAGAACTGCTCCCCA
AAAGAGGAACCATACAAAATGCAAGAAAAGAGCATTCTGAGATGCAGTGAGAATAATGAG
ACCATCAACCACATCATTCCCAACGGGAAATCTGAAGACAGCATTAAGGGCCTTCAGCCT
GAAGATGTTAATCTGTTGGTAACCTGCAGAGAGGAGGGCAACCCAGTGGCATCCTTAGGT
CATTCAGAGGCAGAAACACCAGTTGACGCTTACTCCAATGGGCAAGCAGCTCTCATGGGT
GAGAAAGAGAGAAAGAAAGAAACGGATGATGGAGGTCGGTACTGGAAGTTCATAGACTGG
TTTTGTGGCTTTAAAAGTAAGAGCCTCAGCAAGAGGAGTCTCAGAGACCTGATGGAAGAG
GAGGCTGTTTGTTTACAGATGCTAGAAGAGACTCGGCAAGTTAAAGTAATACTAAATATT
GGACTTTTTGCTGTGTGTTCACTTGGAATTTTCATGTTTGTTTATTTCTCCTTATGA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
L38500

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_6_Locus:
Not Available

# Macromolecular_Interacting_Partner_6_SNPs:
Not Available

# Macromolecular_Interacting_Partner_6_General_References:
7789985; 9441750; 10830953

# Macromolecular_Interacting_Partner_6_References:
10051678; 8550845; 9633613

# Macromolecular_Interacting_Partner_7_ID:
8745

# Macromolecular_Interacting_Partner_7_Name:
CDNA FLJ20001 fis, clone ADKA01273

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>CDNA FLJ20001 fis, clone ADKA01273
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
303

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
33907

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
5.28

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
 Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  S-methyltransferase activity
Function:  homocysteine S-methyltransferase activity
 ||
>>>
 Process:  Not Available
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Amino acid transport and metabolism

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF02574:S-methyl_trans

# Macromolecular_Interacting_Partner_7_Signals:
Not Available

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
7019812

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
Q9NXX7_HUMAN (Q9NXX7)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
BHMT2

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
BHMT2

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:1048

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>912 bp
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTGGGAAGATGTAAATGCTGCTGCCTGTGACCTCGCCAGGGAA
GTGGCTGGCAAAGGTGATGCTTTGGTAGCAGGGGGGATCTGCCAGACATCAATATACAAA
TACCAGAAGGATGAAGCTAGAATTAAAAAACTTTTTCGACAACAGCTAGAAGTTTTTGCC
TGGAAAAATGTGGACTTCTTGATTGCAGAGTATTTTGAGCACGTTGAAGAAGCTGTGTGG
GCTGTGGAAGTCTTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCA
GAGGGAGACATGCATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGG
GCTTCCATCGTTGGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAG
CTCATGAAGGAGGGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTG
GGGTTCCACGCGCCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTT
GGACTGGAGTCCAGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTAC
AACCTGGGGGTCAGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCA
ATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGC
AGCTGGGGAAGTGGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGG
GAGTATTGGGAGAATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAG
CCAGACTTCTAA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AK000008

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
Not Available

End of HMDB00043

Beginning of HMDB00044
# Accession_No:
HMDB00044

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-08-09 11:56:06

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Ascorbic acid

# Description:
Ascorbic acid is an essential nutrient in human diets, and is necessary to maintain connective tissue and bone. Its biologically active form is vitamin C. Primates (including humans) and a few other species in all divisions of the animal kingdom, notably the guinea pig, have lost the ability to synthesize ascorbic acid and must obtain it in their food.  Ascorbic acid is an electron donor for enzymes involved in collagen hydroxylation, biosynthesis of carnitine and norepinephrine, tyrosine metabolism, and amidation of peptide hormones; its deficiency causes scurvy. The amount of vitamin C necessary to prevent scurvy may not be adequate to maintain optimal health. The ability of vitamin C to donate electrons also makes it a potent water-soluble antioxidant that readily scavenges free radicals such as molecular oxygen, superoxide, hydroxyl radical, and hypochlorous acid. In this setting, several mechanisms could account for a link between vitamin C and heart disease. One is the relation between LDL oxidation and vitamins C and E. Vitamin C in vitro can recycle vitamin E, which can donate electrons to prevent LDL oxidation in vitro. As the lipid-phase vitamin E is oxidized, it can be regenerated by aqueous vitamin C. Other possibilities are that vitamin C could decrease cholesterol by mechanisms not well characterized, or could improve vasodilatation and vascular reactivity, perhaps by decreasing the interactions of nitric oxide with oxidants. (PMID 10799361)

# Synonyms:
(+)-ascorbate; (+)-ascorbic acid; 3-Keto-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone; AA; Adenex; Allercorb; Antiscorbic vitamin; Antiscorbutic vitamin; Arco-cee; Ascoltin; Ascor-B.I.D.; Ascorb; Ascorbajen; Ascorbate; Ascorbic acid; Ascorbicab; Ascorbicap; Ascorbicin; Ascorbin; Ascorbutina; Ascorin; Ascorteal; Ascorvit; C-level; C-long; C-quin; C-span; C-vimin; Cantan; Cantaxin; Catavin C; Ce lent; Ce-mi-lin; Ce-vi-sol; Cebicure; Cebid; Cebion; Cebione; Cecon; Cee-caps TD; Cee-vite; Cegiolan; Ceglion; Ceklin; Celaskon; Celin; Cell C; Cemagyl; Cemill; Cenetone; Cenolate; Cereon; Cergona; Cescorbat; Cetamid; Cetane; Cetane-caps TC; Cetane-caps TD; Cetebe; Cetemican; Cevalin; Cevatine; Cevex; Cevi-bid; Cevimin; Cevital; Cevitamate; Cevitamic acid; Cevitamin; Cevitan; Cevitex; Cewin; Chewcee; Ciamin; Cipca; Citriscorb; Citrovit; Colascor; Concemin; Davitamon C; Dora-C-500; Duoscorb; Ferrous ascorbate; HiCee; Hybrin; Ido-C; Juvamine; Kangbingfeng; Kyselina askorbova; L(+)-ascorbate; L(+)-ascorbic acid; L-(+)-ascorbate; L-(+)-ascorbic acid; L-3-Ketothreohexuronic acid lactone; L-Ascorbic acid; L-ascorbate; L-lyxoascorbate; L-lyxoascorbic acid; L-threo-ascorbic acid; L-xyloascorbate; L-xyloascorbic acid; Laroscorbine; Lemascorb; Liqui-cee; Meri-c; Natrascorb; Natrascorb injectable; Planavit C; Proscorbin; Redoxon; Ribena; Ronotec 100; Rontex 100; Roscorbic; Rovimix C; Scorbacid; Scorbu C; Scorbu-C; Secorbate; Sodascorbate; Suncoat VC 40; Testascorbic; VASC; Vicelat; Vicin; Vicomin C; Viforcit; Viscorin; Viscorin 100M; Vitace; Vitacee; Vitacimin; Vitacin; Vitamin C; Vitamisin; Vitascorbol; Xitix; gamma-lactone L-threo-Hex-2-enonate; gamma-lactone L-threo-Hex-2-enonic acid; (+)-Sodium L-ascorbate 

# Chemical_IUPAC_Name:
(2S)-2-[(1R)-1,2-dihydroxyethyl]-4,5-dihydroxy-furan-3-one

# Chemical_Formula:
C6H8O6

# Chemical_Structure:
tbl_chemical:::HMDB00044_ZOOM.png:::119283152112449081

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00044_THUMB.png:::119283151919155272

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Vitamins

# Taxonomy_Family:
Food Additive

# Taxonomy_Species:
1,2-diol; heterocyclic compound; ketone; primary alcohol; secondary alcohol

# Taxonomy_Biofunction:
Essential vitamins; Anti-oxidant; Enzyme co-factor; Component of Tyrosine metabolism

# Taxonomy_Source:
Exogenous

# Molecular_Weight:
176.03209

# Molecular_Weight_Avg:
176.12411

# Smiles_String_isomeric:
OC[C@@H](O)[C@@H]1OC(O)=C(O)C1=O

# Smiles_String_canonical:
OCC(O)C1OC(O)=C(O)C1=O

# KEGG_Compound_ID:
C00072

# BioCyc_ID:
ASCORBATE

# PubChem_CID:
644104

# PubChem_SID:
15971359; 3372; 841571

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
33747

# Wikipedia_ID:
Ascorbic acid

# METLIN_ID:
3753

# Ref_ID:
1529283; 11978879; 7711198; 11984597; 15917019; 15190049; 2026685; 16425787; 15925292; 15640471; 16725131; 11805243; 16872308; 8726814; 12180551; 8467348; 16611389; 10920885; 16522902

# ChEBI_ID:
29073

# CAS_Registry_Number:
50-81-7

# InChI:
InChI=1/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8,10-11H,1H2/t2-,5+/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
191 oC

# Melting_Point_predicted:
93.4 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
400 mg/mL at 40 oC [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
257.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.85 [AVDEEF,A (1997)]

# LogP_predicted:
-0.5 [Predicted by PubChem via XLOGP]; -1.86 [Predicted by ALOGPS]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::1165972662.html:::119922412670520>>>tbl_chemical:::1165972521.pdf:::181994583902466

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::1165972667.mol:::220767058971676

# SDF_File_[Text]:
tbl_chemical:::HMDB00044.sdf:::119283151506633936

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00044.pdb:::119283151745911924

# PDB_ID:
1E71

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_PRESAT_expanded_2.gif:::114460751565281319

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_presat.zip:::1175124395811910950

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041006_P00_03_HW_1DP_Assigned.png:::118045649283220794

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041006_P00_03_HW_1DP_presat.png:::114857302878585889

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041006_P00_03_HW_1DP_presat.zip:::114857422569317711

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684.png:::114789845502657772

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684.zip:::114789845507845484

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041006_P00_03_HW_2DHSQC_684_Assigned.png:::115083184638692848

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ascorbic acid.gif:::1132732102250142987

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00044_peaks.txt:::1156309508028431139

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Ascorbic acid_C.gif:::1132737666350346925

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00044_peaks.txt:::1156310699632397897

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00044L.png:::11755526205815134; Medium Energy:tbl_ms:::HMDB00044M.png:::117555267123411632; High Energy:tbl_ms:::HMDB00044H.png:::117555271008459939

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000182.png:::116907444473492105

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000182.txt:::116907444471835399

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000182.png:::116890830384352293

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000182.txt:::116890830409321134

# Cellular_Location:
Cytoplasm; Extracellular

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Medulla; Bladder; Brain; Epidermis; Erythrocyte; Eye Lens; Fibroblasts; Gonads; Heart; Intestine; Liver; Lung; Lymphocyte; Most Tissues; Muscle; Myelin; Neurons; Placenta; Platelet; Prostate; Skeletal Muscle; Spleen

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	63.6 +/-142.9	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	2026685
Blood	88.6 (21.0 - 171.0)	umol/L	Children:1-13_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	60.8 +/- 15.9	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	51.0 (11.0 - 125.0)	umol/L	Newborn:0-30_days_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	34.0 (0 - 85.0)	umol/L	Children:1-13_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.
Blood	36.0 +/- 18.0	uM	Adult:>18_yrs_old	Both	Normal	15640471
Blood	63.0 (11.0-114.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	22.2 (14.0-40.0)	uM	Adult:>18_yrs_old	Both	Normal	16522902
Cerebrospinal_Fluid(CSF)	68.0 (17.0-119.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	163.8 +/- 21	umol/L	Adult:>18_yrs_old	N/A	Normal	11978879
Cerebrospinal_Fluid(CSF)	164.0 (143.0-185.0)	uM	Adult:>18_yrs_old	Both	Normal	11978879
Cerebrospinal_Fluid(CSF)	144.0 (36.2-251.0)	umol/L	Adult:>18_yrs_old	Both	Normal	11805243
Cellular_Cytoplasm	68.0 +/- 43.0	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 132. Edited by Cornelius Lentner. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp. Basle, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	53.8 (45.8-61.8)	umol/L	Adult:>18_yrs_old	Both	Pediatric traumatic brain injury	11978879
Cerebrospinal_Fluid(CSF)	11.9 (0.0-24)	umol/L	Adult:>18_yrs_old	Both	Bacterial meningitis	11805243


# Associated_Disorders:
Antidiuresis; Bacterial meningitis; Cardiovascular Disease; Charcot-Marie-Tooth Disease; Iron Deficiency; Pediatric traumatic brain injury; Scurvy; Steoporosis; Uroporphyria

# Pathway_Names:
Lysine degradation

# Pathway_Images:
Lysine_degradation.jpg

# KEGG_Images:
map00310

# Pathway_Graphs:
Lysine_degradation_Graph.jpg

# Pathway_SBMLs:
Lysine_degradation.xml

# Metabolic_Enzyme_1_ID:
5700

# Metabolic_Enzyme_1_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor

# Metabolic_Enzyme_1_Synonyms:
Lysyl hydroxylase 2; LH2

# Metabolic_Enzyme_1_Gene_Name:
PLOD2

# Metabolic_Enzyme_1_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 2 precursor
MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAK
YFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAG
GPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIV
QQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARA
KNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSI
GVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIV
GPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTR
HGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERN
YFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDW
KEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRIS
GGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQ
RSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEG
LPVKNGTRYIAVSFIDP

# Metabolic_Enzyme_1_Number_of_Residues:
737

# Metabolic_Enzyme_1_Molecular_Weight:
84686

# Metabolic_Enzyme_1_Theoretical_pI:
6.69

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_1_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_1_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2138314

# Metabolic_Enzyme_1_SwissProt_ID:
PLOD2_HUMAN (O00469)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
PLOD2

# Metabolic_Enzyme_1_Geneatlas_id:
PLOD2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:9082

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_1_Gene_Sequence:
>2214 bp
ATGGGGGGATGCACGGTGAAGCCTCAGCTGCTGCTCCTGGCGCTCGTCCTCCACCCCTGG
AATCCCTGTCTGGGTGCGGACTCGGAGAAGCCCTCGAGCATCCCCACAGATAAATTATTA
GTCATAACTGTAGCAACAAAAGAAAGTGATGGATTCCATCGATTTATGCAGTCAGCCAAA
TATTTCAATTATACTGTGAAGGTCCTTGGTCAAGGAGAAGAATGGAGAGGTGGTGATGGA
ATTAATAGTATTGGAGGGGGCCAGAAAGTGAGATTAATGAAAGAAGTCATGGAACACTAT
GCTGATCAAGATGATCTGGTTGTCATGTTTACTGAATGCTTTGATGTCATATTTGCTGGT
GGTCCAGAAGAAGTTCTAAAAAAATTCCAAAAGGCAAACCACAAAGTGGTCTTTGCAGCA
GATGGAATTTTGTGGCCAGATAAAAGACTAGCAGACAAGTATCCTGTTGTGCACATTGGG
AAACGCTATCTGAATTCAGGAGGATTTATTGGCTATGCTCCATATGTCAACCGTATAGTT
CAACAATGGAATCTCCAGGATAATGATGATGATCAGCTCTTTTACACTAAAGTTTACATT
GATCCACTGAAAAGGGAAGCTATTAACATCACATTGGATCACAAATGCAAAATTTTCCAG
ACCTTAAATGGAGCTGTAGATGAAGTTGTTTTAAAATTTGAAAATGGCAAAGCCAGAGCT
AAGAATACATTTTATGAAACATTACCAGTGGCAATTAATGGAAATGGACCCACCAAGATT
CTCCTGAATTATTTTGGAAACTATGTACCCAATTCATGGACACAGGATAATGGCTGCACT
CTTTGTGAATTCGATACAGTCGACTTGTCTGCAGTAGATGTCCATCCAAACGTATCAATA
GGTGTTTTTATTGAGCAACCAACCCCTTTTCTACCTCGGTTTCTGGACATATTGTTGACA
CTGGATTACCCAAAAGAAGCACTTAAACTTTTTATTCATAACAAAGAAGTTTATCATGAA
AAGGACATCAAGGTATTTTTTGATAAAGCTAAGCATGAAATCAAAACTATAAAAATAGTA
GGACCAGAAGAAAATCTAAGTCAAGCGGAAGCCAGAAACATGGGAATGGACTTTTGCCGT
CAGGATGAAAAGTGTGATTATTACTTTAGTGTGGATGCAGATGTTGTTTTGACAAATCCA
AGGACTTTAAAAATTTTGATTGAACAAAACAGAAAGATCATTGCTCCTCTTGTAACTCGT
CATGGAAAGCTGTGGTCCAATTTCTGGGGAGCATTGAGTCCTGATGGATACTATGCACGA
TCTGAAGATTATGTGGATATTGTTCAAGGGAATAGAGTAGGAGTATGGAATGTCCCATAT
ATGGCTAATGTGTACTTAATTAAAGGAAAGACACTCCGATCAGAGATGAATGAAAGGAAC
TATTTTGTTCGTGATAAACTGGATCCTGATATGGCTCTTTGCCGAAATGCTAGAGAAATG
GGTGTATTTATGTACATTTCTAATAGACATGAATTTGGAAGGCTATTATCCACTGCTAAT
TACAATACTTCCCATTATAACAATGACCTCTGGCAGATTTTTGAAAATCCTGTGGACTGG
AAGGAAAAGTATATAAACCGTGATTATTCAAAGATTTTCACTGAAAATATAGTTGAACAG
CCCTGTCCAGATGTCTTTTGGTTCCCCATATTTTCTGAAAAAGCCTGTGATGAATTGGTA
GAAGAAATGGAACATTACGGCAAATGGTCTGGGGGAAAACATCATGATAGCCGTATATCT
GGTGGTTATGAAAATGTCCCAACTGATGATATCCACATGAAGCAAGTTGATCTGGAGAAT
GTATGGCTTGATTTTATCCGGGAGTTCATTGCACCAGTTACACTGAAGGTCTTTGCAGGC
TATTATACGAAGGGATTTGCACTACTGAATTTTGTAGTAAAATACTCCCCTGAACGACAG
CGTTCTCTTCGTCCTCATCATGATGCTTCTACATTTACCATAAACATTGCACTTAATAAC
GTGGGAGAAGACTTTCAGGGAGGTGGTTGCAAATTTCTAAGGTACAATTGCTCTATTGAG
TCACCACGAAAAGGCTGGAGCTTCATGCATCCTGGGAGACTCACACATTTGCATGAAGGA
CTTCCTGTTAAAAATGGAACAAGATACATTGCAGTGTCATTTATAGATCCCTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
U84573

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_1_Locus:
3q23-q24

# Metabolic_Enzyme_1_SNPs:
rs6710; rs1707469; rs1868541; rs959329; rs1170389; rs764755; rs1170391; rs10935606; rs1900926; rs4681299; rs1170388; rs1375591; rs7642940; rs6440417; rs1449444; rs3816399; rs965032; rs1707465; rs3792341; rs1170393; rs1349215; rs3804669; rs9852725; rs1170390; rs9289718; rs6802384; rs6801418; rs12496198; rs3804661; rs7613150; rs1349214; rs4681297; rs2029137; rs3792340; rs11718741; rs7614409; rs6783601; rs1707473; rs2864794; rs9289713; rs1512901; rs1512900; rs9289715; rs9865802; rs6800434; rs9836725; rs10935608; rs10935601; rs1449441; rs4681301; rs9862237; rs1375585; rs3762690; rs3804666; rs4681112; rs1375587; rs3792345; rs3762694; rs6793380; rs9878166; rs1707471; rs3804664; rs10935605; rs7639592; rs1613796; rs2864793; rs9842036; rs1375581; rs3804660; rs9877411; rs4681298; rs6783926; rs895930; rs9289716; rs9858095; rs10935604; rs9852153; rs7431590; rs10935607; rs9813047; rs9820945; rs3804665; rs1562699; rs9809099; rs12496358; rs12498084; rs3804663; rs4681300; rs3762691; rs9289717; rs895929; rs6799720; rs6787625; rs1170392; rs1375582; rs12695808; rs3804659; rs1375588; rs1449450; rs3792339; rs2669396; rs9289714; rs3804668; rs6787634; rs4681294; rs1375584; rs4681111; rs1449443; rs7650527; rs7628412; rs963591; rs1868540; rs6440415; rs9881251; rs7650652; rs1868539; rs9869137; rs12632001; rs11919284; rs16857897; rs2864792; rs9822426; rs10935603; rs11717610; rs16857900; rs12492656; rs1449451; rs1449440; rs9842560; rs6440420; rs2029138; rs17413767; rs9828112; rs6781300; rs6440419; rs12495057; rs6793224; rs11914531; rs3828381; rs3804667; rs1613698; rs1375583; rs4681113; rs1982381; rs9836521; rs16857938; rs7628210; rs9842865; rs17412259; rs7641322; rs895928; rs16857916; rs1707472; rs7628222; rs9881772; rs1449442; rs1982382; rs9823126; rs9811822; rs1707479; rs2864795; rs9874388; rs2067375; rs4681295; rs7626859; rs9840602; rs9882583; rs7617913; rs3804670; rs6800294; rs6780480; rs6440418; rs1707466; rs3840209; rs11927032; rs2305274; rs16857919; rs1375589; rs4611785; rs9289712; rs7613937; rs1063157; rs1061261; rs34957134; rs34042812; rs13079521; rs1061262; rs34991720; rs34009978; rs34741228; rs34640052; rs34540779; rs3792347; rs34708378; rs1061260; rs35029247; rs35160202; rs34335756; rs34341243; rs34636181; rs33983488; rs35302944; rs11337357; rs34056190; rs13094630; rs35704675; rs10663177; rs28451909; rs35520151; rs7619272; rs35706246; rs5853263; rs34232127; rs1900929; rs2197908; rs9880704; rs9856304; rs35461076; rs13074471; rs11457807; rs13094640; rs35692942; rs34803917; rs34092280; rs13094892; rs4681296; rs34298175; rs10703593; rs34588668; rs13063652; rs3059069; rs5853265; rs11456176; rs34509746; rs13088659; rs28648696; rs35941599; rs13088180; rs10576552; rs13094632; rs11458112; rs35299945; rs7652622; rs13095083; rs35030961; rs34302224; rs3804662; rs10622187; rs12171294; rs10621402; rs36037345; rs13067100; rs11420653; rs11456231; rs12485544; rs35687630; rs9862265; rs11456819; rs34551842; rs13094655; rs10663152; rs11425603; rs34382856; rs34798280; rs13092649; rs35140877; rs1375580; rs35607678; rs11360876; rs3838608; rs10704713; rs35399797; rs9858081; rs35125036; rs34255485; rs34143458; rs1530742; rs35821615; rs2669397; rs34735927; rs34940478; rs12494929; rs34592151; rs34240070; rs3840208; rs11927021; rs7639115; rs6148118; rs34898407; rs11328609; rs35069585; rs34528837; rs35104103; rs11425393; rs5853262; rs10663012; rs34054457; rs10672417; rs13095103; rs35423942; rs7649967; rs36193485; rs35017529; rs34106207; rs1707468; rs36168881; rs16857921; rs35399421; rs1900928; rs2197907; rs34589717; rs13088158; rs34955707; rs5853266; rs4681293; rs3975816; rs13075266; rs11336772; rs28560023; rs34589948; rs35587646; rs34738950; rs13075648; rs13063887; rs11425913; rs34661470; rs13327204; rs5853264; rs35329274; rs36160119; rs35961312; rs34092722; rs4290778; rs34177874; rs1375586; rs1562700; rs35973610; rs1982383; rs35762539; rs13095139; rs12171307; rs35683071; rs35208268; rs6794727; rs34715073; rs34695557; rs35893777; rs11456175; rs35080774; rs13066226; rs11425298; rs36070925; rs34390384; rs35880309; rs36090265; rs13093088; rs35274473; rs11435306; rs10620863; rs35766352; rs965031; rs35597003; rs10620702; rs35401598; rs1530741; rs35512942; rs34708065; rs35748974; rs13096811; rs3059043; rs10935602; rs35252566; rs9843118; rs3842573; rs34075030; rs34392701; rs35899444; rs10619980; rs6775684; rs34383803; rs35532167; rs921272; rs34722039; rs34901222; rs35969739; rs34464230; rs34717183; rs35269237; rs34471669; rs34583562; rs11721146; rs11916662; rs11917712; rs11917774; rs11917816; rs11919826; rs11923433; rs11925421; rs13087364; rs1375590; rs1449445; rs1449446; rs1449447; rs1512898; rs16857879; rs16857889; rs16857967; rs1900927; rs1913185; rs1913186; rs35880277; rs3749282; rs4342076; rs6768400; rs6768405; rs6771118; rs6792464; rs7623263; rs7645622; rs7646579; rs7646646; rs7646759; rs9853017

# Metabolic_Enzyme_1_General_References:
9054364; 10372558; 12881513

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5539

# Metabolic_Enzyme_2_Name:
Prolyl 4-hydroxylase subunit alpha-1 precursor

# Metabolic_Enzyme_2_Synonyms:
4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit

# Metabolic_Enzyme_2_Gene_Name:
P4HA1

# Metabolic_Enzyme_2_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha1 precursor
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

# Metabolic_Enzyme_2_Number_of_Residues:
534

# Metabolic_Enzyme_2_Molecular_Weight:
61050

# Metabolic_Enzyme_2_Theoretical_pI:
5.84

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_2_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_2_Signals:
1-17

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_2_GenBank_ID_Protein:
190786

# Metabolic_Enzyme_2_SwissProt_ID:
P4HA1_HUMAN (P13674)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
P4HA1

# Metabolic_Enzyme_2_Geneatlas_id:
P4HA1

# Metabolic_Enzyme_2_hgnc_id:
HGNC:8546

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_2_Gene_Sequence:
>1605 bp
ATGATCTGGTATATATTAATTATAGGAATTCTGCTTCCCCAGTCTTTGGCTCATCCAGGC
TTTTTTACTTCAATTGGTCAGATGACTGATTTGATCCATACTGAGAAAGATCTGGTGACT
TCTCTGAAAGATTATATTAAGGCAGAAGAGGACAAGTTAGAACAAATAAAAAAATGGGCA
GAGAAGTTAGATCGGCTAACTAGTACAGCGACAAAAGATCCAGAAGGATTTGTTGGGCAT
CCAGTAAATGCATTCAAATTAATGAAACGTCTGAATACTGAGTGGAGTGAGTTGGAGAAT
CTGGTCCTTAAGGATATGTCAGATGGCTTTATCTCTAACCTAACCATTCAGAGACCAGTA
CTTTCTAATGATGAAGATCAGGTTGGGGCAGCCAAAGCTCTGTTACGTCTCCAGGATACC
TACAATTTGGATACAGATACCATCTCAAAGGGTAATCTTCCAGGAGTGAAACACAAATCT
TTTCTAACGGCTGAGGACTGCTTTGAGTTGGGCAAAGTGGCCTATACAGAAGCAGATTAT
TACCATACGGAACTGTGGATGGAACAAGCCCTAAGGCAACTGGATGAAGGCGAGATTTCT
ACCATAGATAAAGTCTCTGTTCTAGATTATTTGAGCTATGCGGTATATCAGCAGGGAGAC
CTGGATAAGGCACTTTTGCTCACAAAGAAGCTTCTTGAACTAGATCCTGAACATCAGAGA
GCTAATGGTAACTTAAAATATTTTGAGTATATAATGGCTAAAGAAAAAGATGTCAATAAG
TCTGCTTCAGATGACCAATCTGATCAGAAAACTACACCAAAGAAAAAAGGGGTTGCTGTG
GATTACCTGCCAGAGAGACAGAAGTACGAAATGCTGTGCCGTGGGGAGGGTATCAAAATG
ACCCCTCGGAGACAGAAAAAACTCTTTTGCCGCTACCATGATGGAAACCGTAATCCTAAA
TTTATTCTGGCTCCAGCTAAACAGGAGGATGAATGGGACAAGCCTCGTATTATTCGCTTC
CATGATATTATTTCTGATGCAGAAATTGAAATCGTCAAAGACCTAGCAAAACCAAGGCTG
AGCCGAGCTACAGTACATGACCCTGAGACTGGAAAATTGACCACAGCACAGTACAGAGTA
TCTAAGAGTGCCTGGCTCTCTGGCTATGAAAATCCTGTGGTGTCTCGAATTAATATGAGA
ATACAAGATCTAACAGGACTAGATGTTTCCACAGCAGAGGAATTACAGGTAGCAAATTAT
GGAGTTGGAGGACAGTATGAACCCCATTTTGACTTTGCACGGAAAGATGAGCCAGATGCT
TTCAAAGAGCTGGGGACAGGAAATAGAATTGCTACATGGCTGTTTTATATGAGTGATGTG
TCTGCAGGAGGAGCCACTGTTTTTCCTGAAGTTGGAGCTAGTGTTTGGCCCAAAAAAGGA
ACTGCTGTTTTCTGGTATAATCTGTTTGCCAGTGGAGAAGGAGATTATAGTACACGGCAT
GCAGCCTGTCCAGTGCTAGTTGGCAACAAATGGGTATCCAATAAATGGCTCCATGAACGT
GGACAAGAATTTCGAAGACCTTGTACGTTGTCAGAATTGGAATGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M24486

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_2_Locus:
10q21.3-q23.1

# Metabolic_Enzyme_2_SNPs:
rs7920974; rs7078127; rs6480667; rs12570974; rs6480668; rs10823977; rs7905836; rs11000516; rs12242222; rs12260669; rs11000517; rs12242214; rs12571459; rs12573499; rs7095810; rs4405231; rs6480666; rs7095904; rs7088078; rs2394928; rs7072019; rs11000515; rs7915269; rs12217855; rs9787672; rs28384495; rs12261293; rs2394919; rs11597837; rs7077346; rs7077281; rs12766755; rs12573512; rs6480653; rs3736278; rs7094342; rs7072071; rs7904719; rs7076642; rs6480655; rs7085141; rs10823975; rs6480654; rs12253630; rs6480661; rs12244027; rs7908682; rs10762535; rs6480660; rs4572061; rs11000491; rs6480659; rs4387274; rs6480663; rs7078818; rs6480662; rs12253317; rs12261668; rs4366408; rs12255146; rs12249050; rs11000506; rs12248308; rs12262696; rs9663510; rs2394920; rs12260461; rs12253518; rs4469800; rs11000510; rs12244049; rs7095061; rs6480664; rs6480658; rs7911861; rs12247364; rs10458655; rs12249126; rs7912848; rs11000499; rs10823976; rs12241143; rs7903684; rs11000511; rs9787516; rs6480665; rs12258500; rs12243988; rs7898822; rs16930271; rs12769591; rs12249431; rs12243451; rs12571941; rs7918396; rs7901481; rs1140462; rs1130885; rs1130886; rs34567673; rs34312165; rs1130890; rs1130887; rs34845894; rs1130884; rs11000512; rs11559264; rs1130889; rs35382319; rs2894191; rs28679854; rs34584160; rs34990120; rs11334323; rs12764491; rs12264323; rs28548263; rs34903468; rs7913148; rs34088796; rs12259071; rs35281975; rs12778451; rs11000520; rs34996723; rs34701143; rs35214128; rs12253350; rs12777708; rs11000514; rs10823980; rs34645636; rs10691278; rs10674198; rs11000513; rs11340358; rs3065972; rs35159575; rs7072016; rs7076700; rs10700344; rs2894192; rs11336622; rs11000519; rs12764311; rs5786098; rs36056230; rs1804257; rs12764504; rs12780338; rs35811135; rs10561551; rs36105566; rs35838791; rs12572256; rs35462247; rs10674781; rs11400869; rs11000497; rs28692884; rs11599563; rs10649250; rs4745712; rs12416008; rs35466966; rs12164712; rs17658374; rs12769358; rs11000505; rs11393613; rs34854861; rs12262881; rs34399366; rs11000508; rs34610783; rs11389497; rs3830350; rs12771344; rs35884198; rs35112393; rs11275675; rs11814343; rs3998391; rs7896744; rs12248714; rs7913609; rs34379137; rs12255388; rs11000500; rs12262986; rs11000504; rs12246277; rs34457485; rs11527421; rs35176849; rs3065978; rs12416021; rs35875050; rs10603432; rs12258140; rs2894193; rs11498022; rs11000503; rs12258753; rs35527169; rs12240932; rs41307520; rs34420722; rs9663290; rs35435004; rs36107511; rs12570010; rs11000493; rs12411647; rs28853423; rs2394929; rs35190522; rs12246228; rs5786097; rs10539580; rs35067388; rs7921747; rs7902639; rs10584360; rs11000502; rs34461487; rs35914404; rs36080367; rs12251674; rs12253449; rs11498023; rs11398474; rs2394921; rs7908892; rs41315002; rs9732032; rs12262714; rs35537940; rs11000494; rs41307512; rs12248134; rs35484631; rs9787606; rs4745711; rs35199506; rs12243819; rs34565865; rs7095773; rs10634037; rs10661785; rs11497795; rs7912619; rs34677025; rs12263220; rs10698728; rs11000486; rs11000487; rs11000488; rs11000489; rs11000490; rs11813121; rs12573768; rs16930262; rs2394924; rs2394925; rs2394926; rs34162681; rs35323750; rs3998396; rs4258298; rs4522088; rs4529828; rs7071334; rs7076718; rs7077056; rs7078081; rs7082363; rs7094115; rs7894359; rs7896197; rs7897191; rs7906123; rs7907485; rs7922533

# Metabolic_Enzyme_2_General_References:
2543975; 7961714

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5484

# Metabolic_Enzyme_3_Name:
Peptidyl-glycine alpha-amidating monooxygenase precursor

# Metabolic_Enzyme_3_Synonyms:
PAM[Includes: Peptidylglycine alpha-hydroxylating monooxygenase; PHM; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidylamidoglycolate lyase; PAL]

# Metabolic_Enzyme_3_Gene_Name:
PAM

# Metabolic_Enzyme_3_Protein_Sequence:
>Peptidylglycine alphaamidating monooxygenase precursor
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS

# Metabolic_Enzyme_3_Number_of_Residues:
973

# Metabolic_Enzyme_3_Molecular_Weight:
108333

# Metabolic_Enzyme_3_Theoretical_pI:
6.39

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  peptidylglycine monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  peptide metabolism
 ||
>>>
Component:  cell
Component:  membrane

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Bifunctional enzyme that catalyzes 2 sequencial steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
peptidylamidoglycolate = peptidyl amide + glyoxylate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF01436:NHL

# Metabolic_Enzyme_3_Signals:
1-20

# Metabolic_Enzyme_3_Transmembrane_Regions:
864-887

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.14.17.3;EC 4.3.2.5

# Metabolic_Enzyme_3_GenBank_ID_Protein:
189595

# Metabolic_Enzyme_3_SwissProt_ID:
AMD_HUMAN (P19021)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PAM

# Metabolic_Enzyme_3_Geneatlas_id:
PAM

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8596

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Isoform 1:Membrane; single-pass type I membrane protein. Isoform 2:Membrane; single-pass type I membrane protein. Isoform 3:Secreted protein. Isoform 4:Secreted protein. Note=Secreted from secretory granules

# Metabolic_Enzyme_3_Gene_Sequence:
>2925 bp
ATGGCTGGCCGCGTCCCTAGCCTGCTAGTTCTCCTTGTTTTTCCAAGCAGCTGTTTGGCT
TTCCGAAGCCCACTTTCTGTCTTTAAGAGGTTTAAAGAAACTACCAGACCATTTTCCAAT
GAATGTCTTGGTACCACCAGACCCGTAGTTCCTATTGATTCATCAGATTTTGCATTGGAT
ATTCGCATGCCTGGGGTTACACCTAAACAGTCCGATACATACTTCTGCATGTCTATGCGA
ATACCAGTGGATGAGGAAGCCTTCGTGATTGACTTCAAGCCTCGAGCCAGCATGGATACT
GTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTGGTTT
TGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCT
CCCCCTACCCGGCTCCCCAAAGGTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAA
TACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAGATAATAACAAGGAC
TGTTCTGGTGTGTCCTTACACCTCACACGTCTGCCACAGCCTTTAATTGCTGGCATGTAC
CTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAGTGGTGAATTCTGACATT
TCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCAT
TTAGGTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGG
CAGAGCCCTCAGCTGCCACAGGCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTT
GGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACAC
ATTGGTGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCC
AAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACC
ATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAA
CATCATAAAGAAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAA
GAAGAAGAAGTGTTAGACCAGGGTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAA
AGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCA
GACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCC
AGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAA
TTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAG
CCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAGATTTCCACATGGAAGAG
GCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGAC
CCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAACTCGTTT
GACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTT
GTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGAAAAAAATCTGTTTTACTTG
CCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCAT
CAGGTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGC
ATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCA
GGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCA
CCAAGTGGAAAGTTCATCACACAGTGGGGAGAAGAGTCTTCAGGGAGCAGTCCTCTGCCA
GGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTG
GCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGA
GAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAGGCTTG
CTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTG
ATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAGCACTTTGAT
ATGCCTCATGATATTGTTGCATCTGAAGATGGGACCGTGTACATTGGAGATGCTCATACC
AACACCGTGTGGAAGTTCACCTTGACTGAGAAATTGGAACATCGATCAGTTAAAAAGGCT
GGCATTGAGGTCCAGGAAATCAAAGAAGCCGAGGCAGTTGTTGAAACCAAAATGGAGAAC
AAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAGCTGATCAAAGAGCCA
GGCTCGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTG
CTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGAGCAGATTCTGAA
CACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAGGAAAGGGAAGTGGA
GGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGAC
CGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAG
GAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M37721

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2357221; 7999037; 8486658; 8144680

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5485

# Metabolic_Enzyme_4_Name:
Dopamine beta-hydroxylase precursor

# Metabolic_Enzyme_4_Synonyms:
Dopamine beta- monooxygenase

# Metabolic_Enzyme_4_Gene_Name:
DBH

# Metabolic_Enzyme_4_Protein_Sequence:
>Dopamine betahydroxylase precursor
MREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLELSWNVSYTQEAIHF
QLLVRRLKAG
VLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQKGQIHLDPQQDYQL
LQVQRTPEGLTLLFKRPFGTC
DPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGL
QRVQLLKPNIPEPELPSDACTMEVQAPNIQIP
SQETTYWCYIKELPKGFSRHHIIKYEP
IVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNY
CRHVLAAWALGAKAFY
YPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRFNAGI
MELGL
VYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKVVTVLVRDGR
EWEIV
NQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGGFGILEEMC
VNYVHYYPQTQLELCK
SAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFTSVPWNSF
NRDVLKALYSFAPISMHCNKSSAVRFQ
GEWNLQPLPKVISTLEEPTPQCPTSQGRSPAG
PTVVSIGGGKG

# Metabolic_Enzyme_4_Number_of_Residues:
603

# Metabolic_Enzyme_4_Molecular_Weight:
67614

# Metabolic_Enzyme_4_Theoretical_pI:
6.31

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Not Available

# Metabolic_Enzyme_4_Specific_Function:
Conversion of dopamine to noradrenaline

# Metabolic_Enzyme_4_Pathway:
map00350  Tyrosine metabolism

# Metabolic_Enzyme_4_Reaction:
3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF03712:Cu2_monoox_C;
PF01082:Cu2_monooxygen;
PF03351:DOMON

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.17.1

# Metabolic_Enzyme_4_GenBank_ID_Protein:
30474

# Metabolic_Enzyme_4_SwissProt_ID:
DOPO_HUMAN (P09172)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
DBH

# Metabolic_Enzyme_4_Geneatlas_id:
DBH

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2689

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasmic vesicle; secretory vesicle; chromaffin granule. Cytoplasmic vesicle; secretory vesicle; chromaffin granule; chromaffin granule membrane. Note=Exists both in a soluble form (in chromaffin granules) and as membrane bound (the membrane bound form is anchored by an uncleaved signal peptide)

# Metabolic_Enzyme_4_Gene_Sequence:
>1812 bp

ATGCGGGAGGCAGCCTTCATGTACAGCACAGCAGTGGCCATCTTCCTGGTCATCCTGGT
GGCCGCACTGC
AGGGCTCGGCTCCCCGTGAGAGCCCCCTCCCCTATCACATCCCCCTGG
ACCCGGAGGGGTCCCTGGAGCT
CTCATGGAATGTCAGCTACACCCAGGAGGCCATCCAT
TTCCAGCTCCTGGTGCGGAGGCTCAAGGCTGGC
GTCCTGTTTGGGATGTCCGACCGTGG
CGAGCTTGAGAACGCAGATCTCGTGGTGCTCTGGACCGATGGGG
ACACTGCCTATTTTG
CGGACGCCTGGAGTGACCAGAAGGGGCAGATCCACCTGGATCCCCAGCAGGACTA
CCAG
CTGCTGCAGGTGCAGAGGACCCCAGAAGGCCTGACCCTGCTTTTCAAGAGGCCCTTTGGC
ACCTGC
GACCCCAAGGATTACCTCATTGAAGACGGCACTGTCCACTTGGTCTACGGGAT
CCTGGAGGAGCCGTTCC
GGTCACTGGAGGCCATCAACGGCTCGGGCCTGCAGATGGGGC
TGCAGAGGGTGCAGCTCCTGAAGCCCAA
TATCCCCGAACCGGAGTTGCCCTCAGACGCG
TGCACCATGGAGGTCCAAGCTCCCAATATCCAGATCCCC
AGCCAGGAGACCACGTACTG
GTGCTACATTAAGGAGCTTCCAAAGGGCTTCTCTCGGCACCACATTATCA
AGTACGAGC
CCATCGTCACCAAGGGCAATGAGGCCCTTGTCCACCACATGGAAGTCTTCCAGTGCGCCC
C
CGAGATGGACAGCGTCCCCCACTTCAGCGGGCCCTGCGACTCCAAGATGAAACCCGAC
CGCCTCAACTAC
TGCCGCCACGTGCTGGCCGCCTGGGCCCTGGGTGCCAAGGCATTTTA
CTACCCAGAGGAAGCCGGCCTTG
CCTTCGGGGGTCCAGGGTCCTCCAGATATCTCCGCC
TGGAAGTTCACTACCACAACCCACTGGTGATAGA
AGGACGAAACGACTCCTCAGGCATC
CGCTTGTACTACACAGCCAAGCTGCGGCGCTTCAACGCGGGGATC
ATGGAGCTGGGACT
GGTGTACACGCCAGTGATGGCCATTCCACCACGGGAGACCGCCTTCATCCTCACTG
GCT
ACTGCACGGACAAGTGCACCCAGCTGGCACTGCCTCCCTCCGGGATCCACATCTTCGCCT
CTCAGCT
CCACACACACCTGACTGGGAGAAAGGTGGTCACAGTGCTGGTCCGGGACGGC
CGGGAGTGGGAGATCGTG
AACCAGGACAATCACTACAGCCCTCACTTCCAGGAGATCCG
CATGTTGAAGAAGGTCGTGTCGGTCCATC
CGGGAGATGTGCTCATCACCTCCTGCACGT
ACAACACGGAAGACCGGGAGCTGGCCACAGTGGGGGGCTT
CGGGATCCTGGAGGAGATG
TGTGTCAACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAG
ACGGCTGT
GGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGATGT
CT
GCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCT
TCAACCGCGACGT
ACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAAC
AAGTCCTCAGCCGTCCGCTTCCAG
GGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCA
CCAGCCAGGGCCGAAGCCCTGCTG
GCCCCACCGTTGTCAGCATTGGTGGGGGCAAAGGCTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X13255

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34

# Metabolic_Enzyme_4_SNPs:
rs5324; rs5320; rs4531; rs5325; rs1108580; rs77905; rs5322; rs5318; rs2519154; rs2797849; rs1541333; rs6479643; rs1611126; rs1108581; rs7035577; rs2797853; rs7876027; rs1611122; rs1611130; rs1611124; rs3025399; rs12343735; rs3025405; rs2797852; rs1541332; rs3025383; rs2519143; rs1611120; rs1611128; rs1611123; rs1611119; rs7862391; rs3025411; rs3025395; rs9657707; rs3025391; rs2519151; rs3025382; rs2007153; rs2797855; rs2283123; rs2283124; rs3025388; rs2519155; rs2873804; rs1548364; rs80858; rs1611125; rs2797851; rs739398; rs3025390; rs3025410; rs129911; rs10993947; rs2283122; rs129913; rs3025413; rs1548367; rs10121827; rs3025401; rs12003344; rs3025387; rs3025403; rs2519153; rs2797854; rs7870239; rs3025393; rs129910; rs7864658; rs2005663; rs3025404; rs3025406; rs1611127; rs2797850; rs3025408; rs3739885; rs129908; rs2519157; rs129909; rs1611118; rs2519152; rs13284520; rs3025392; rs2519144; rs1611114; rs1611115; rs129883; rs129915; rs12002610; rs3025379; rs1611116; rs13306301; rs41316996; rs2797848; rs5319; rs5323; rs3025380; rs13306306; rs5321; rs13306303; rs17851478; rs35465867; rs3025400; rs35043556; rs3739886; rs35067824; rs3025381; rs28419319; rs3025415; rs1548365; rs28481752; rs5901024; rs3081166; rs13306307; rs3025385; rs1611129; rs35246072; rs12001868; rs2519156; rs35528158; rs11278217; rs11283016; rs13293282; rs3025428; rs34469151; rs13306302; rs3025430; rs35806215; rs35682711; rs28662126; rs7032535; rs34932746; rs12003763; rs3025416; rs3025427; rs3025384; rs3025426; rs1548366; rs3025389; rs4333676; rs3025398; rs28738882; rs13306308; rs1548368; rs129912; rs3025386; rs7027680; rs28698922; rs1611121; rs35688529; rs12005180; rs3025396; rs5901023; rs3025414; rs28534474; rs3025407; rs13306305; rs3025402; rs3025429; rs3025409; rs35808071; rs3025394; rs3025412; rs34553440; rs34242880; rs13298385; rs34701710; rs34498190; rs3025377; rs1611117; rs12684659; rs3025433; rs10993904; rs3025432; rs13285918; rs3025378; rs2797847; rs1076150; rs1076153; rs10993885; rs10993886; rs10993948; rs10993949; rs10993950; rs12337651; rs129882; rs129884; rs129885; rs129888; rs129914; rs129916; rs129917; rs129918; rs129919; rs129921; rs129922; rs129923; rs129924; rs129925; rs129926; rs129928; rs129929; rs129930; rs129931; rs17150766; rs1989787; rs2073833; rs2073835; rs2073836; rs2073837; rs2097628; rs2519145; rs2519147; rs2519148; rs2519149; rs2519764; rs2519765; rs3025369; rs3025370; rs3025371; rs3025372; rs3025373; rs3025374; rs3025375; rs3025376; rs3025417; rs3025418; rs3025419; rs3025421; rs3025422; rs3025423; rs3025424; rs3025425; rs3025431; rs3025434; rs3025435; rs3025436; rs3025437; rs3025438; rs3025439; rs3025440; rs3025441; rs3025443; rs6271; rs7043939; rs732833; rs7851898; rs7859358; rs9409875

# Metabolic_Enzyme_4_General_References:
2922261; 3443096; 8546710; 10490716; 10391209; 10391210; 11857564

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5699

# Metabolic_Enzyme_5_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor

# Metabolic_Enzyme_5_Synonyms:
Lysyl hydroxylase 1; LH1

# Metabolic_Enzyme_5_Gene_Name:
PLOD1

# Metabolic_Enzyme_5_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 1 precursor
MRPLLLLALLGWLLLAEAKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWNVEKGTSAGGGQKVRLLKKALEKHADKEDLVILFADSYDVLFASGPRELLKKFRQA
RSQVVFSAEELIYPDRRLETKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQ
LFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGHVRARNLAYDTLPVLI
HGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPF
VSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQSVKLVGPEVRMANAD
ARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTRHGRLWSNFWG
ALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHSKLDPD
MAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYT
KALAGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTID
IHMNQIGFEREWHKFLLEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLMPHHDAS
TFTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYI
AVSFVDP

# Metabolic_Enzyme_5_Number_of_Residues:
727

# Metabolic_Enzyme_5_Molecular_Weight:
83551

# Metabolic_Enzyme_5_Theoretical_pI:
6.94

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_5_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_5_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_5_Signals:
1-18

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_5_GenBank_ID_Protein:
190074

# Metabolic_Enzyme_5_SwissProt_ID:
PLOD1_HUMAN (Q02809)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
PLOD1

# Metabolic_Enzyme_5_Geneatlas_id:
PLOD1

# Metabolic_Enzyme_5_hgnc_id:
HGNC:9081

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_5_Gene_Sequence:
>2184 bp
ATGCGGCCCCTGCTGCTACTGGCCCTGCTGGGCTGGCTGCTGCTGGCCGAAGCGAAGGGC
GACGCCAAGCCGGAGGACAACCTTTTAGTCCTCACGGTGGCCACTAAGGAGACCGAGGGA
TTCCGTCGCTTCAAGCGCTCAGCTCAGTTCTTCAACTACAAGATCCAGGCGCTTGGCCTA
GGGGAGGACTGGAATGTGGAGAAGGGGACGTCGGCAGGTGGAGGGCAGAAGGTCCGGCTG
CTGAAGAAAGCTCTGGAGAAGCACGCAGACAAGGAGGATCTGGTCATTCTCTTCACAGAC
AGCTATGACGTGCTGTTTGCATCGGGGCCCCGGGAGCTCCTGAAGAAGTTCCGGCAGGCC
AGGAGCCAGGTGGTCTTCTCTGCTGAGGAGCTCATCTACCCAGACCGCAGGCTGGAGACC
AAGTATCCGGTGGTGTCCGATGGCAAGAGGTTCCTGGGCTCTGGAGGCTTCATCGGTTAT
GCCCCCAACCTCAGCAAACTGGTGGCCGAGTGGGAGGGCCAGGACAGCGACAGCGATCAG
CTGTTTTACACCAAGATCTTCTTGGACCCGGAGAAGAGGGAGCAGATCAATATCACCCTG
GACCACCGCTGCCGTATCTTCCAGAACCTGGATGGAGCCTTGGATGAGGTCGTGCTCAAG
TTTGAAATGGGCCATGTGAGAGCGAGGAACCTGGCCTATGACACCCTCCCGGTCCTGATC
CATGGCAACGGGCCAACCAAGCTGCAGTTGAACTACCTGGGCAACTACATCCCGCGCTTC
TGGACCTTCGAAACAGGCTGCACCGTGTGTGACGAAGGCTTGCGCAGCCTCAAGGGCATT
GGGGATGAAGCTCTGCCCACGGTCCTGGTCGGCGTGTTCATCGAACAGCCCACGCCGTTT
GTGTCCCTGTTCTTCCAGCGGCTCCTGCGGCTCCACTACCCCCAGAAACACATGCGACTT
TTCATCCACAACCACGAGCAGCACCACAAGGCTCAGGTGGAAGAGTTCCTGGCACAGCAT
GGCAGCGAGTACCAGTCTGTGAAGCTGGTGGGCCCTGAGGTGCGGATGGCGAATGCAGAT
GCCAGGAACATGGGCGCAGACCTGTGCCGGCAGGACCGCAGCTGCACCTACTACTTCAGC
GTGGATGCTGACGTGGCCCTGACCGAGCCCAACAGCCTGCGGCTGCTGATCCAACAGAAC
AAGAATGTCATTGCCCCGCTGATGACCCGGCATGGGAGGCTGTGGTCGAACTTCTGGGGG
GCTCTCAGTGCAGATGGCTACTATGCCCGTTCCGAGGACTACGTGGACATTGTGCAGGGG
CGGCGTGTTGGTGTCTGGAATGTGCCCTATATTTCAAACATCTACTTGATCAAGGGCAGT
GCCCTGCGGGGTGAGCTGCAGTCCTCAGATCTCTTCCACCACAGCAAGCTGGACCCCGAC
ATGGCCTTCTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGCAC
ACCCTTGGCCATCTGCTCTCCCTAGACAGCTACCGCACCACCCACCTGCACAACGACCTC
TGGGAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAAGTACATCCACCAGAACTACACC
AAAGCCCTGGCAGGGAAGCTGGTGGAGACGCCCTGCCCGGATGTCTATTGGTTCCCCATC
TTCACGGAGGTGGCCTGTGATGAGCTGGTGGAGGAGATGGAGCACTTTGGCCAGTGGTCT
CTGGGCAACAACAAGGACAACCGCATCCAGGGTGGCTACGAGAACGTGCCGACTATTGAC
ATCCACATGAACCAGATCGGCTTTGAGCGGGAGTGGCACAAATTCCTGCTGGAGTACATT
GCGCCCATGACGGAGAAGCTCTACCCCGGCTACTACACCAGGGCCCAGTTTGACCTGGCC
TTTGTCGTCCGCTACAAGCCTGATGAGCAGCCCTCACTGATGCCACACCATGATGCCTCC
ACCTTCACCATCAACATCGCCCTGAACCGAGTCGGGGTGGATTACGAGGGCGGGGGCTGT
CGGTTCCTGCGCTACAACTGTTCCATCCGAGCCCCAAGGAAGGGCTGGACCCTCATGCAC
CCTGGACGACTCACGCATTACCATGAGGGGCTCCCCACCACCAGGGGCACCCGCTACATC
GCAGTCTCCTTCGTCGATCCCTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
L06419

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_5_Locus:
1p36.3-p36.2

# Metabolic_Enzyme_5_SNPs:
rs7551175; rs34878020; rs7551068; rs2273285; rs879690; rs7514577; rs7529452; rs34032489; rs7541079; rs879691; rs35460537; rs2230898; rs2230899; rs2273289; rs1208984; rs3818157; rs2273286; rs6674558; rs1540923; rs7529028; rs2273293; rs6697996; rs2207751; rs4846080; rs3737961; rs2273291; rs3766746; rs6674770; rs7554458; rs760188; rs6665648; rs11585018; rs744754; rs11121846; rs11121845; rs1040669; rs2336381; rs6541011; rs11581068; rs2273290; rs11121844; rs2092857; rs6703931; rs6678553; rs2273288; rs1964839; rs12567779; rs736302; rs11802668; rs3820190; rs11121843; rs6690517; rs7513651; rs6658386; rs7538358; rs11799416; rs7521172; rs7543487; rs760189; rs2180180; rs6682230; rs2273287; rs1811858; rs2336379; rs7543471; rs7529312; rs11810010; rs1208985; rs11584187; rs1075579; rs7543484; rs7418108; rs12564031; rs1966174; rs11587948; rs12061195; rs11553672; rs3177759; rs11553674; rs11553676; rs36005914; rs35958757; rs11553679; rs11553677; rs35656581; rs1804187; rs15431; rs1049519; rs11553681; rs11553673; rs1063393; rs6685691; rs34974878; rs7514470; rs12737433; rs11809981; rs12130493; rs35648170; rs12404000; rs12037764; rs12752010; rs34390330; rs12079940; rs34115393; rs12753494; rs1806948; rs34499671; rs11585264; rs12037576; rs5772480; rs2336380; rs5772479; rs35059519; rs12743705; rs7414602; rs12094848; rs12749807; rs34636670; rs41278622; rs34707621; rs760190; rs35329388; rs6693015; rs35661025; rs33981344; rs2878680; rs12093915; rs4044690; rs2224103; rs35357427; rs1964840; rs35378361; rs3047221; rs34228351; rs35857830; rs35486766; rs6143123; rs4044691; rs35153449; rs35104601; rs12736906; rs34918895; rs34167429; rs6665708; rs35350400; rs35807940; rs11809682; rs41307745; rs4044692; rs12737438; rs35226154; rs12736958; rs6670260; rs12037575; rs3047155; rs12130497; rs35125262; rs34216020; rs12088157; rs34657615; rs1208983; rs12024161; rs35625768; rs12403086; rs1474868; rs2180181; rs2180182; rs2180183; rs2236053; rs2236054; rs2236055; rs34758260; rs3753579; rs3766744; rs4240897; rs4845891; rs4846082; rs6682554; rs7551289

# Metabolic_Enzyme_5_General_References:
1577494; 7713497; 8621606; 8163671; 9617436; 10686424

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5619

# Metabolic_Enzyme_6_Name:
Gamma-butyrobetaine dioxygenase

# Metabolic_Enzyme_6_Synonyms:
Gamma-butyrobetaine,2- oxoglutarate dioxygenase; Gamma-butyrobetaine hydroxylase; Gamma- BBH

# Metabolic_Enzyme_6_Gene_Name:
BBOX1

# Metabolic_Enzyme_6_Protein_Sequence:
>Gammabutyrobetaine dioxygenase
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDV
NIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSEL
QLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHT
WQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQK
LKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIF
DVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISR
HLEGAYADWDVVMSRLRILRQRVENGN

# Metabolic_Enzyme_6_Number_of_Residues:
387

# Metabolic_Enzyme_6_Molecular_Weight:
44715

# Metabolic_Enzyme_6_Theoretical_pI:
6.73

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the formation of L-carnitine from gamma- butyrobetaine

# Metabolic_Enzyme_6_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_6_Reaction:
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF02668:TauD

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.11.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
3746805

# Metabolic_Enzyme_6_SwissProt_ID:
BODG_HUMAN (O75936)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
BBOX1

# Metabolic_Enzyme_6_Geneatlas_id:
BBOX1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:964

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_6_Gene_Sequence:
>1164 bp
ATGGCTTGTACCATCCAAAAGGCAGAAGCACTTGACGGGGCTCATTTGATGCAGATCCTC
TGGTATGATGAGGAAGAGTCTCTCTACCCAGCTGTATGGTTGAGAGACAACTGTCCGTGC
TCTGATTGCTACCTGGATTCTGCAAAAGCACGGAAACTTCTAGTGGAAGCTCTTGATGTG
AACATTGGAATTAAAGGCTTGATATTTGACAGAAAAAAGGTGTACATCACATGGCCCGAT
GAGCATTACAGTGAATTCCAGGCTGATTGGCTGAAGAAAAGATGCTTTTCCAAGCAGGCC
AGAGCAAAGCTCCAAAGAGAATTGTTTTTTCCAGAATGCCAATACTGGGGCTCAGAGCTC
CAGCTACCCACTTTGGATTTTGAAGATGTTTTAAGATATGATGAACATGCATACAAGTGG
CTCTCCACCCTCAAGAAAGTAGGCATAGTAAGACTCACCGGAGCATCTGACAAACCAGGA
GAAGTTTCAAAACTTGGGAAAAGGATGGGTTTCCTCTATCTCACATTTTATGGACATACT
TGGCAAGTGCAAGACAAAATCGATGCAAACAATGTGGCTTACACAACTGGGAAGCTAAGC
TTTCACACTGATTATCCAGCCCTCCATCATCCACCTGGGGTTCAGCTTCTTCACTGCATA
AAGCAAACAGTCACAGGGGGTGATTCAGAAATTGTAGATGGGTTTAATGTGTGCCAAAAA
CTAAAGAAAAATAATCCTCAGGCATTCCAGATTTTGTCCTCTACCTTTGTGGACTTTACA
GACATTGGAGTGGATTACTGTGATTTTTCTGTACAATCAAAACATAAAATTATAGAGTTA
GATGATAAAGGCCAAGTGGTTCGCATCAACTTCAATAACGCAACTAGGGACACAATATTT
GATGTACCTGTTGAAAGAGTTCAGCCTTTTTATGCTGCTCTGAAGGAGTTTGTTGACCTC
ATGAACAGCAAAGAATCCAAGTTTACCTTCAAGATGAATCCAGGTGATGTGATTACTTTT
GATAACTGGCGCTTACTTCATGGCCGACGTAGCTATGAAGCAGGAACTGAGATATCCCGC
CATCTAGAAGGAGCTTATGCTGACTGGGATGTGGTCATGTCAAGGCTTCGTATCTTAAGG
CAGAGGGTGGAGAATGGAAACTGA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF082868

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_6_Locus:
11p14.2

# Metabolic_Enzyme_6_SNPs:
rs3183973; rs1044273; rs12385796; rs11029801; rs10835105; rs10767595; rs10835108; rs4923415; rs7107938; rs1031176; rs1445329; rs7108209; rs1348655; rs9667425; rs10767594; rs1596713; rs11029799; rs1445317; rs2305095; rs7113488; rs7124309; rs11029803; rs7479320; rs11029798; rs1445316; rs11029797; rs11029802; rs4922782; rs10767596; rs1596711; rs4923413; rs1044281; rs11029810; rs1445318; rs1445328; rs7124431; rs10835106; rs10767593; rs11029805; rs987687; rs1317726; rs1442936; rs1550617; rs2015372; rs1470272; rs972904; rs12275053; rs7119888; rs7926773; rs4532991; rs4923423; rs1372902; rs7937175; rs10835118; rs7124821; rs7945305; rs1596252; rs7949619; rs7926376; rs4923424; rs11029818; rs1470270; rs1470271; rs1442924; rs7931643; rs11821389; rs1899506; rs7926257; rs1442934; rs16916562; rs2304912; rs7932626; rs11819947; rs7925797; rs1372903; rs2218317; rs1020269; rs7121579; rs4328173; rs3781677; rs11605939; rs10835109; rs10767609; rs11029819; rs996081; rs7930844; rs4923419; rs7926675; rs11029812; rs10835114; rs1442939; rs1445315; rs1126029; rs11029816; rs11824620; rs17309677; rs4278476; rs17243943; rs1584011; rs1372910; rs2099887; rs1442940; rs6484265; rs10767604; rs1442935; rs10501075; rs1900062; rs2165771; rs2165772; rs1899505; rs7942200; rs7129825; rs7124528; rs2165769; rs16916527; rs17309656; rs16925449; rs7111206; rs1117933; rs12292769; rs10835111; rs2016186; rs1442918; rs10767611; rs12294451; rs7934926; rs12271270; rs7925996; rs10835115; rs12270852; rs7105366; rs1596253; rs11029835; rs11029822; rs1442942; rs7949163; rs7124982; rs2083746; rs2351072; rs1596256; rs10835110; rs10767601; rs12269821; rs11029817; rs17309642; rs11029840; rs7927654; rs16916550; rs10501076; rs11511900; rs12282206; rs2083745; rs9666732; rs11828630; rs7951152; rs1838016; rs10767608; rs2351071; rs7103662; rs11029821; rs17243908; rs10767599; rs16916541; rs11029811; rs11029827; rs7936060; rs7101475; rs12786889; rs7113071; rs10835116; rs12288789; rs7926243; rs1550618; rs12277039; rs11029837; rs11602261; rs16916491; rs10767607; rs10742167; rs1348333; rs2351069; rs12285287; rs4539271; rs17243895; rs16916545; rs1442938; rs10767603; rs1813232; rs7939588; rs985597; rs11029833; rs1372904; rs11029795; rs11029796; rs10767592; rs979894; rs16916476; rs10767598; rs11029804; rs11029809; rs10719276; rs7117298; rs35636374; rs4923417; rs7105192; rs11029806; rs7128441; rs12576172; rs34097371; rs34660864; rs11029808; rs34766807; rs35376713; rs11029800; rs35917669; rs12283507; rs34065143; rs7126240; rs35189764; rs11029807; rs4345921; rs12276511; rs5790623; rs34538592; rs4923416; rs12223912; rs28541300; rs10835107; rs4145909; rs34110652; rs1596712; rs2351065; rs34027150; rs12806691; rs5790624; rs5790626; rs7948922; rs12270866; rs35004823; rs12795106; rs34667672; rs11029814; rs1155086; rs7939156; rs33920700; rs11029823; rs12281762; rs1900061; rs969853; rs7118962; rs2165770; rs1596257; rs1442941; rs34033631; rs7121302; rs2099886; rs4456220; rs34651018; rs34566186; rs35133358; rs7106871; rs12796032; rs1900064; rs12283762; rs10767602; rs996080; rs35379904; rs11029829; rs2351068; rs3858352; rs12798621; rs12285873; rs1442937; rs35762464; rs7124832; rs12290117; rs35689575; rs12280183; rs12795275; rs34531204; rs35556063; rs11029813; rs34883956; rs12417452; rs12797016; rs34406124; rs5790625; rs2218316; rs34886674; rs7933763; rs1899507; rs1596255; rs35869743; rs34503251; rs35209473; rs34621792; rs11336654; rs6484262; rs34420345; rs11354714; rs35233420; rs2351073; rs2120970; rs11396790; rs36115556; rs34989862; rs34990215; rs34914489; rs7930368; rs7128424; rs34552334; rs2351067; rs12281711; rs3077755; rs2197193; rs4923422; rs1900063; rs34309577; rs7126076; rs33933274; rs34717773; rs35737389; rs35645117; rs12291195; rs34595485; rs10597096; rs6484263; rs12419903; rs11029825; rs35248831; rs1822333; rs35620055; rs1156471; rs1126030; rs11820992; rs35105576; rs2351066; rs3077754; rs2304913; rs34317776; rs12795462; rs35203991; rs12803967; rs2351070; rs11373738; rs28635996; rs11029820; rs10589070; rs2197189; rs1126028; rs34754536; rs11371497; rs2197192; rs11029815; rs1596254; rs34399289; rs35655267; rs35671221; rs12282200; rs12049843; rs7478929; rs35821992; rs1900065; rs34920955; rs35825160; rs11029826; rs35329237; rs6484266; rs3214719; rs6484264; rs11442866; rs34255947; rs12796839; rs13377286; rs12796835; rs12277417; rs12291206; rs34851998; rs7358459; rs963185; rs34250561; rs12289983; rs5790630; rs7358458; rs35814179; rs2012032; rs5790629; rs4279971; rs12417081; rs5790628; rs5790627; rs11300902; rs35939379; rs1025879; rs10501077; rs10501078; rs10501079; rs10742166; rs11029792; rs11825838; rs11828263; rs12577769; rs1348331; rs1584010; rs16916608; rs1838009; rs2083743; rs3802783; rs4923411; rs4923412; rs4923425; rs7131593; rs7933314; rs7933773; rs7939644

# Metabolic_Enzyme_6_General_References:
9753662

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5701

# Metabolic_Enzyme_7_Name:
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor

# Metabolic_Enzyme_7_Synonyms:
Lysyl hydroxylase 3; LH3

# Metabolic_Enzyme_7_Gene_Name:
PLOD3

# Metabolic_Enzyme_7_Protein_Sequence:
>Procollagenlysine,2oxoglutarate 5dioxygenase 3 precursor
MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAE
FFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAG
SPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIV
RQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRI
RNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFL
AVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLV
GPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSR
HGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRD
VFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDW
KEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRL
AGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDE
QPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHE
GLPTTWGTRYIMVSFVDP

# Metabolic_Enzyme_7_Number_of_Residues:
738

# Metabolic_Enzyme_7_Molecular_Weight:
84786

# Metabolic_Enzyme_7_Theoretical_pI:
5.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  procollagen-lysine 5-dioxygenase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  endoplasmic reticulum

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links

# Metabolic_Enzyme_7_Pathway:
map00310  Lysine degradation

# Metabolic_Enzyme_7_Reaction:
procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy

# Metabolic_Enzyme_7_Signals:
1-24

# Metabolic_Enzyme_7_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.14.11.4

# Metabolic_Enzyme_7_GenBank_ID_Protein:
3153235

# Metabolic_Enzyme_7_SwissProt_ID:
PLOD3_HUMAN (O60568)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PLOD3

# Metabolic_Enzyme_7_Geneatlas_id:
PLOD3

# Metabolic_Enzyme_7_hgnc_id:
HGNC:9083

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum; rough endoplasmic reticulum membrane; peripheral membrane protein; lumenal side

# Metabolic_Enzyme_7_Gene_Sequence:
>2217 bp
ATGACCTCCTCGGGGCCTGGACCCCGGTTCCTGCTGCTGCTGCCGCTGCTGCTGCCCCCT
GCGGCCTCAGCCTCCGACCGGCCCCGGGGCCGAGACCCGGTCAACCCAGAGAAGCTGCTG
GTGATCACTGTGGCCACAGCTGAAACCGAGGGGTACCTGCGTTTCCTGCGCTCTGCGGAG
TTCTTCAACTACACTGTGCGGACCCTGGGCCTGGGAGAGGAGTGGCGAGGGGGTGATGTG
GCTCGAACAGTTGGTGGAGGACAGAAGGTCCGGTGGTTAAAGAAGGAAATGGAGAAATAC
GCTGACCGGGAGGATATGATCATCATGTTTGTGGATAGCTACGACGTGATTCTGGCCGGC
AGCCCCACAGAGCTGCTGAAGAAGTTCGTCCAGAGTGGCAGCCGCCTGCTCTTCTCTGCA
GAGAGCTTCTGCTGGCCCGAGTGGGGGCTGGCGGAGCAGTACCCTGAGGTGGGCACGGGG
AAGCGCTTCCTCAATTCTGGTGGATTCATCGGTTTTGCCACCACCATCCACCAAATCGTG
CGCCAGTGGAAGTACAAGGATGATGACGACGACCAGCTGTTCTACACACGGCTCTACCTG
GACCCAGGACTGAGGGAGAAACTCAGCCTTAATCTGGATCATAAGTCTCGGATCTTTCAG
AACCTCAACGGGGCTTTAGATGAAGTGGTTTTAAAGTTTGATCGGAACCGTGTGCGTATC
CGGAACGTGGCCTACGACACGCTCCCCATTGTGGTCCATGGAAACGGTCCCACTAAGCTG
CAGCTCAACTACCTGGGAAACTACGTCCCCAATGGCTGGACTCCTGAGGGAGGCTGTGGC
TTCTGCAACCAGGACCGGAGGACACTCCCGGGGGGGCAGCCTCCCCCCCGGGTGTTTCTG
GCCGTGTTTGTGGAACAGCCTACTCCGTTTCTGCCCCGCTTCCTGCAGCGGCTGCTACTC
CTGGACTATCCCCCCGACAGGGTCACCCTTTTCCTGCACAACAACGAGGTCTTCCATGAA
CCCCACATCGCTGACTCCTGGCCGCAGCTCCAGGACCACTTCTCAGCTGTGAAGCTCGTG
GGGCCGGAGGAGGCTCTGAGCCCAGGCGAGGCCAGGGACATGGCCATGGACCTGTGTCGG
CAGGACCCCGAGTGTGAGTTCTACTTCAGCCTGGACGCCGACGCTGTCCTCACCAACCTG
CAGACCCTGCGTATCCTCATTGAGGAGAACAGGAAGGTGATCGCCCCCATGCTGTCCCGC
CACGGCAAGCTGTGGTCCAACTTCTGGGGCGCCCTGAGCCCCGATGAGTACTACGCCCGC
TCCGAGGACTACGTGGAGCTGGTGCAGCGGAAGCGAGTGGGTGTGTGGAATGTACCATAC
ATCTCCCAGGCCTATGTGATCCGGGGTGATACCCTGCGGATGGAGCTGCCCCAGAGGGAT
GTGTTCTCGGGCAGTGACACAGACCCGGACATGGCCTTCTGTAAGAGCTTTCGAGACAAG
GGCATCTTCCTCCATCTGAGCAATCAGCATGAATTTGGCCGGCTCCTGGCCACTTCCAGA
TACGACACGGAGCACCTGCACCCCGACCTCTGGCAGATCTTCGACAACCCCGTCGACTGG
AAGGAGCAGTACATCCACGAGAACTACAGCCGGGCCCTGGAAGGGGAAGGAATCGTGGAG
CAGCCATGCCCGGACGTGTACTGGTTCCCACTGCTGTCAGAACAAATGTGTGATGAGCTG
GTGGCAGAGATGGAGCACTACGGCCAGTGGTCAGGCGGCCGGCATGAGGATTCAAGGCTG
GCTGGAGGCTACGAGAATGTGCCCACCGTGGACATCCACATGAAGCAGGTGGGGTACGAG
GACCAGTGGCTGCAGCTGCTGCGGACGTATGTGGGCCCCATGACCGAGAGCCTGTTTCCC
GGTTACCACACCAAGGCGCGGGCGGTGATGAACTTTGTGGTTCGCTACCGGCCAGACGAG
CAGCCGTCTCTGCGGCCACACCACGACTCATCCACCTTCACCCTCAACGTTGCCCTCAAC
CACAAGGGCCTGGACTATGAGGGAGGTGGCTGCCGCTTCCTGCGCTACGACTGTGTGATC
TCCTCCCCGAGGAAGGGCTGGGCACTCCTGCACCCCGGCCGCCTCACCCACTACCACGAG
GGGCTGCCAACGACCTGGGGCACACGCTACATCATGGTGTCCTTTGTCGACCCCTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF046889

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_7_Locus:
7q22

# Metabolic_Enzyme_7_SNPs:
rs1546841; rs1546840; rs7777930; rs1468358; rs9656066; rs2214708; rs4729671; rs917112; rs1546842; rs3213663; rs2301903; rs2286120; rs11973058; rs11975752; rs11975104; rs4729670; rs2301904; rs7802724; rs1972170; rs12667795; rs35929039; rs1134907; rs41281013; rs11546151; rs11546152; rs11546150; rs41281010; rs3779113; rs1811203; rs3988238; rs28373136; rs1972169; rs2107803; rs33991024; rs11971003; rs11973909; rs35647633; rs35513430; rs11525849; rs3988239; rs5886172; rs10233414; rs11525848; rs3779114; rs7799197; rs11295764; rs41281007; rs12670371; rs35753125; rs11525850; rs34242341; rs11974067; rs1811204; rs11977763; rs35607207; rs13244924; rs35664086; rs35159319; rs1004242; rs10215517; rs10246301; rs10260707; rs10265206; rs10487887; rs1056678; rs10953329; rs11769624; rs12410; rs12674140; rs13232135; rs17319250; rs2072168; rs2074685; rs34646598; rs35159414; rs35627324; rs3735337; rs3735338; rs4729669; rs6967483

# Metabolic_Enzyme_7_General_References:
9582318; 9724729; 10686427; 12853948

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5537

# Metabolic_Enzyme_8_Name:
Prolyl 4-hydroxylase subunit alpha-2 precursor

# Metabolic_Enzyme_8_Synonyms:
4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit

# Metabolic_Enzyme_8_Gene_Name:
P4HA2

# Metabolic_Enzyme_8_Protein_Sequence:
>Prolyl 4hydroxylase subunit alpha2 precursor
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS
WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQR
QFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEG
DYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSH
ERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVK
LTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK
LARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVAN
YGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKK
GTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD

# Metabolic_Enzyme_8_Number_of_Residues:
535

# Metabolic_Enzyme_8_Molecular_Weight:
60903

# Metabolic_Enzyme_8_Theoretical_pI:
5.43

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Not Available

# Metabolic_Enzyme_8_Specific_Function:
Catalyzes the posttranslational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

# Metabolic_Enzyme_8_Pathway:
map00330  Arginine and proline metabolism

# Metabolic_Enzyme_8_Reaction:
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF03171:2OG-FeII_Oxy;
PF08336:P4Ha_N;
PF07719:TPR_2

# Metabolic_Enzyme_8_Signals:
1-21

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 1.14.11.2

# Metabolic_Enzyme_8_GenBank_ID_Protein:
2439985

# Metabolic_Enzyme_8_SwissProt_ID:
P4HA2_HUMAN (O15460)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
P4HA2

# Metabolic_Enzyme_8_Geneatlas_id:
P4HA2

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8547

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum lumen

# Metabolic_Enzyme_8_Gene_Sequence:
>1608 bp
ATGAAACTCTGGGTGTCTGCATTGCTGATGGCCTGGTTTGGTGTCCTGAGCTGTGTGCAG
GCCGAATTCTTCACCTCTATTGGGCACATGACTGACCTGATTTATGCAGAGAAAGAGCTG
GTGCAGTCTCTGAAAGAGTACATCCTTGTGGAGGAAGCCAAGCTTTCCAAGATTAAGAGC
TGGGCCAACAAAATGGAAGCCTTGACTAGCAAGTCAGCTGCTGATGCTGAGGGCTACCTG
GCTCACCCTGTGAATGCCTACAAACTGGTGAAGCGGCTAAACACAGACTGGCCTGCGCTG
GAGGACCTTGTCCTGCAGGACTCAGCTGCAGGTTTTATCGCCAACCTCTCTGTGCAGCGG
CAGTTCTTCCCCACTGATGAGGACGAGATAGGAGCTGCCAAAGCCCTGATGAGACTTCAG
GACACATACAGGCTGGACCCAGGCACAATTTCCAGAGGGGAACTTCCAGGAACCAAGTAC
CAGGCAATGCTGAGTGTGGATGACTGCTTTGGGATGGGCCGCTCGGCCTACAATGAAGGG
GACTATTATCATACGGTGTTGTGGATGGAGCAGGTGCTAAAGCAGCTTGATGCCGGGGAG
GAGGCCACCACAACCAAGTCACAGGTGCTGGACTACCTCAGCTATGCTGTCTTCCAGTTG
GGTGATCTGCACCGTGCCCTGGAGCTCACCCGCCGCCTGCTCTCCCTTGACCCAAGCCAC
GAACGAGCTGGAGGGAATCTGCGGTACTTTGAGCAGTTATTGGAGGAAGAGAGAGAAAAA
ACGTTAACAAATCAGACAGAAGCTGAGCTAGCAACCCCAGAAGGCATCTATGAGAGGCCT
GTGGACTACCTGCCTGAGAGGGATGTTTACGAGAGCCTCTGTCGTGGGGAGGGTGTCAAA
CTGACACCCCGTAGACAGAAGAGGCTTTTCTGTAGGTACCACCATGGCAACAGGGCCCCA
CAGCTGCTCATTGCCCCCTTCAAAGAGGAGGACGAGTGGGACAGCCCGCACATCGTCAGG
TACTACGATGTCATGTCTGATGAGGAAATCGAGAGGATCAAGGAGATCGCAAAACCTAAA
CTTGCACGAGCCACCGTTCGTGATCCCAAGACAGGAGTCCTCACTGTCGCCAGCTACCGG
GTTTCCAAAAGCTCCTGGCTAGAGGAAGATGATGACCCTGTTGTGGCCCGAGTAAATCGT
CGGATGCAGCATATCACAGGGTTAACAGTAAAGACTGCAGAATTGTTACAGGTTGCAAAT
TATGGAGTGGGAGGACAGTATGAACCGCACTTCGACTTCTCTAGGAATGATGAGCGAGAT
ACTTTCAAGCATTTAGGGACGGGGAATCGTGTGGCTACTTTCTTAAACTACATGAGTGAT
GTAGAAGCTGGTGGTGCCACCGTCTTCCCTGATCTGGGGGCTGCAATTTGGCCTAAGAAG
GGTACAGCTGTGTTCTGGTACAACCTCTTGCGGAGCGGGGAAGGTGACTACCGAACAAGA
CATGCTGCCTGCCCTGTGCTTGTGGGCTGCAAGTGGGTCTCCAATAAGTGGTTCCATGAA
CGAGGACAGGAGTTCTTGAGACCTTGTGGATCAACAGAAGTTGACTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
U90441

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_8_Locus:
5q31

# Metabolic_Enzyme_8_SNPs:
rs7733814; rs157578; rs154486; rs6596070; rs4705849; rs4705926; rs154487; rs7733502; rs11952765; rs128738; rs156029; rs283753; rs246107; rs152047; rs152051; rs156025; rs75189; rs3805681; rs3828675; rs154484; rs3749756; rs3805683; rs4361509; rs2278398; rs12653783; rs7703009; rs12657965; rs156023; rs17618350; rs3792894; rs10052046; rs152050; rs7701237; rs154483; rs156030; rs10075459; rs156027; rs283763; rs17165741; rs159903; rs152049; rs2301579; rs154485; rs188199; rs2081274; rs152048; rs17165762; rs17618604; rs10520127; rs3214098; rs152053; rs159899; rs157577; rs3805685; rs156032; rs246108; rs156033; rs156034; rs7702160; rs3805684; rs1126979; rs1126978; rs3211283; rs28752075; rs41298340; rs34435009; rs15826; rs35313991; rs1008564; rs35334449; rs34045212; rs35183308; rs392587; rs182092; rs185857; rs28692687; rs35974099; rs36094565; rs185858; rs3840353; rs10656798; rs176112; rs13186538; rs3991665; rs36046040; rs28542593; rs35791773; rs2048473; rs172231; rs34410092; rs35792165; rs1987404; rs184015; rs415986; rs175091; rs13166357; rs34132804; rs34157941; rs390763; rs5871448; rs182249; rs13166329; rs35884065; rs446415; rs13186642; rs13179264; rs10065782; rs424089; rs205547; rs34601928; rs35102688; rs13166927; rs166902; rs35194004; rs35497617; rs13166479; rs364504; rs34049016; rs13166932; rs156026; rs185616; rs6875603; rs34637952; rs35626181; rs35536064; rs10036208; rs10051679; rs10058655; rs11741341; rs11749843; rs11952065; rs11955347; rs13188221; rs13190293; rs1511675; rs152055; rs156031; rs156036; rs17165720; rs17165721; rs2077380; rs2089855; rs2405271; rs408931; rs6896703; rs743563; rs9791170

# Metabolic_Enzyme_8_General_References:
9211872; 11606192; 12975309

# Metabolic_Enzyme_8_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
8548

# Macromolecular_Interacting_Partner_1_Name:
Glutaredoxin-2, mitochondrial precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
GLRX2

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Glutaredoxin2, mitochondrial precursor
MIWRRAALAGTRLVWSRSGSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQI
QETISDNCVVIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERT
VPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKEFQ

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
164

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
18052

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.49

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
 Function:  transporter activity
Function:  electron transporter activity
 ||
>>>
 Process:  homeostasis
Process:  cell homeostasis
Process:  cell redox homeostasis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Posttranslational modification, protein turnover, chaperones

# Macromolecular_Interacting_Partner_1_Specific_Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00462:Glutaredoxin

# Macromolecular_Interacting_Partner_1_Signals:
1-21

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
9507250

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
GLRX2_HUMAN (Q9NS18)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
GLRX2

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
GLRX2

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:16065

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Isoform 1:Mitochondrion. Isoform 2:Nucleus

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>495 bp
ATGATTTGGCGCCGCGCGGCGCTGGCGGGGACGCGGCTGGTTTGGAGCAGGAGCGGCTCG
GCAGGCTGGCTTGACAGGGCGGCGGGAGCTGCGGGAGCTGCGGCAGCTGCGGCCTCTGGG
ATGGAGAGCAATACATCATCATCTTTGGAGAATTTAGCGACGGCGCCTGTGAACCAGATC
CAAGAAACAATTTCTGATAATTGTGTGGTGATTTTCTCAAAAACATCCTGTTCTTACTGT
ACAATGGCAAAAAAGCTTTTCCATGACATGAATGTTAACTATAAAGTGGTGGAACTGGAC
CTGCTTGAATATGGAAACCAGTTCCAAGATGCTCTTTACAAAATGACTGGTGAAAGAACT
GTTCCAAGAATATTTGTCAATGGTACTTTTATTGGAGGTGCAACTGACACTCATAGGCTT
CACAAAGAAGGAAAATTGCTCCCACTAGTTCATCAGTGTTATTTAAAAAAAAGTAAGAGG
AAAGAATTTCAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AF132495

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_1_Locus:
1q31.2-q31.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs10921310; rs1075661; rs912071; rs34353394; rs10801174; rs4657845; rs34961778; rs10801175; rs35995477; rs34839556; rs34603073; rs35057393; rs34029525; rs35843003; rs35891969; rs34615282; rs35358794; rs35214819; rs34147192; rs34533242; rs34839876; rs35629623; rs34589675; rs34833502; rs34262844; rs35241972; rs7544830; rs7547615; rs912070; rs36120583; rs35070966; rs35221108; rs35686837; rs36087945; rs34552619; rs34084081; rs34237236; rs1075660; rs35090051; rs34475657; rs10690193; rs3079948; rs12724659; rs34778656; rs35831330; rs12118724; rs35434160; rs34014687; rs34692395; rs34575782; rs35982829; rs34547448; rs34721216; rs1221539; rs35923929; rs34048785; rs35558858; rs35024625; rs12089411; rs10733078; rs10737620; rs12083536; rs12097567; rs12123511; rs4657843; rs4657844; rs6665069; rs6703727; rs7519292; rs956164; rs9783104

# Macromolecular_Interacting_Partner_1_General_References:
11297543; 11397793; 10810093

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
8602

# Macromolecular_Interacting_Partner_2_Name:
Hypothetical protein CYBRD1

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
CYBRD1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Hypothetical protein CYBRD1
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVF
IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLH
SWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTE
KLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGG
TEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
286

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
31642

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.02

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
 Function:  Not Available
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
 Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF03188:Cytochrom_B561

# Macromolecular_Interacting_Partner_2_Signals:
1-27

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
9-31; 51-73; 85-107; 122-144; 157-179; 199-218

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
62822181

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
Q53TN4_HUMAN (Q53TN4)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
CYBRD1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
CYBRD1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:20797

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Membrane

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>861 bp
ATGGCCATGGAGGGCTACTGGCGCTTCCTGGCGCTGCTGGGGTCGGCACTGCTCGTCGGC
TTCCTGTCGGTGATCTTCGCCCTCGTCTGGGTCCTCCACTACCGAGAGGGGCTTGGCTGG
GATGGGAGCGCACTAGAGTTTAACTGGCACCCAGTGCTCATGGTCACCGGCTTCGTCTTC
ATCCAGGGCATCGCCATCATCGTCTACAGACTGCCGTGGACCTGGAAATGCAGCAAGCTC
CTGATGAAATCCATCCATGCAGGGTTAAATGCAGTTGCTGCCATTCTTGCAATTATCTCT
GTGGTGGCCGTGTTTGAGAACCACAATGTTAACAATATAGCCAATATGTACAGTCTGCAC
AGCTGGGTTGGACTGATAGCTGTCATATGCTATTTGTTACAGCTTCTTTCAGGTTTTTCA
GTCTTTCTGCTTCCATGGGCTCCGCTTTCTCTCCGAGCATTTCTCATGCCCATACATGTT
TATTCTGGAATTGTCATCTTTGGAACAGTGATTGCAACAGCACTTATGGGATTGACAGAG
AAACTGATTTTTTCCCTGAGAGATCCTGCATACAGTACATTCCCGCCAGAAGGTGTTTTC
GTAAATACGCTTGGCCTTCTGATCCTGGTGTTCGGGGCCCTCATTTTTTGGATAGTCACC
AGACCGCAATGGAAACGTCCTAAGGAGCCAAATTCTACCATTCTTCATCCAAATGGAGGC
ACTGAACAGGGAGCAAGAGGTTCCATGCCAGCCTACTCTGGCAACAACATGGACAAATCA
GATTCAGAGTTAAACAGTGAAGTAGCAGCAAGGAAAAGAAACTTAGCTCTGGATGAGGCT
GGGCAGAGATCTACCATGTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AC007969

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_2_Locus:
2q31.1

# Macromolecular_Interacting_Partner_2_SNPs:
rs10455; rs950163; rs2542938; rs2542940; rs525; rs2542939; rs7585194; rs1047023; rs528; rs1060248; rs1047255; rs6758658; rs12999437; rs3821083; rs12328205; rs16859496; rs1047109; rs2542941; rs11675373; rs7596578; rs11684782; rs968379; rs17554; rs6749185; rs4467241; rs6730441; rs6743679; rs7586144; rs6759240; rs6734372; rs12472239; rs12692966; rs10930479; rs10171386; rs6726306; rs17288042; rs6734880; rs17288294; rs13392902; rs13430202; rs960748; rs16859447; rs10930480; rs16859443; rs960749; rs6751899; rs2356784; rs17288588; rs6731190; rs6710032; rs16859468; rs6741930; rs13024499; rs16859480; rs6730957; rs17222606; rs13009270; rs12475526; rs6704600; rs13418789; rs6706526; rs17288182; rs16859473; rs11687075; rs16823212; rs13428567; rs12999785; rs3049; rs17222641; rs960750; rs3806565; rs12621138; rs1558938; rs11889213; rs884409; rs12692965; rs3806566; rs12692964; rs2674485; rs868106; rs11889130; rs2356782; rs12617802; rs3731976; rs12614717; rs1606927; rs16859487; rs6759970; rs34421610; rs11297167; rs13025082; rs11558131; rs35678610; rs35005621; rs3770417; rs6746474; rs35380972; rs11274272; rs11681001; rs35581304; rs11304118; rs28427085; rs10623587; rs34470927; rs5836342; rs13019199; rs13403066; rs13017139; rs34116694; rs7598064; rs11675978; rs13020413; rs11885559; rs13406134; rs6751911; rs35154976; rs12617339; rs12476341; rs35050777; rs11680991; rs10690489; rs35421358; rs34403080; rs10707105; rs28480510; rs12996339; rs2111719; rs35411294; rs13008611; rs11680989; rs13008482; rs11675982; rs2160850; rs35117681; rs7557499; rs35349251; rs11463294; rs34765726; rs13406106; rs34401954; rs34470385; rs35813699; rs34532626; rs34186168; rs13414895; rs34029335; rs35880894; rs35382628; rs6704910; rs10618404; rs6747652; rs35498424; rs10183083; rs7585974; rs12614720; rs1850033; rs3806568; rs10200648; rs1850032; rs11685419; rs884408; rs10199858; rs7586174; rs10490602; rs10490603; rs11674142; rs11680268; rs11896718; rs12052537; rs12618506; rs13406777; rs13410165; rs1476110; rs16859549; rs17221848; rs17289223; rs2111720; rs2356783; rs2542944; rs2542945; rs2542946; rs2542947; rs2674489; rs2674490; rs2674491; rs2674492; rs2674493; rs2674494; rs2674495; rs2674498; rs2674499; rs2674500; rs3806562; rs3806563; rs3806564; rs4668390; rs6433294; rs6433298; rs6711792; rs6720267; rs6724344; rs6725897; rs6732719; rs7575788; rs7580094; rs918231

# Macromolecular_Interacting_Partner_2_General_References:
Not Available

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
8667

# Macromolecular_Interacting_Partner_3_Name:
Solute carrier family 23 member 1

# Macromolecular_Interacting_Partner_3_Synonyms:
Sodium-dependent vitamin C transporter 1; hSVCT1; Na(+/L-ascorbic acid transporter 1; Yolk sac permease-like molecule 3

# Macromolecular_Interacting_Partner_3_Gene_Name:
SLC23A1

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Solute carrier family 23 member 1
MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTI
AVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKA
ILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALL
NYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRW
GKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIA
PWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGI
FTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALF
ASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPG
AINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSS
LKSYDFPIGMGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETASVCTKV

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
598

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
64816

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.58

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_3_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_3_Specific_Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00860:Xan_ur_permease

# Macromolecular_Interacting_Partner_3_Signals:
1-274

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
53-73
82-102
104-124
160-180
208-228
251-271
313-333
359-379
403-423
427-447
458-478
491-511

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
3789785

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
S23A1_HUMAN (Q9UHI7)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
SLC23A1

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
SLC23A1

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:10974

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>1797 bp
ATGAGGGCCCAGGAGGACCTCGAGGGCCGGACACAGCATGAAACCACCAGGGACCCCTCG
ACCCCGCTACCCACAGAGCCTAAGTTTGACATGTTGTACAAGATCGAGGACGTGCCACCT
TGGTACCTGTGCATCCTGCTAGGGTTCCAGCACATCCATGACTGCTTACGTGGTACCATC
GCCGTGCCCTTCCTGCTGGCTGAGGCGCTGTGTGTGGGCCACAGCCAGACACTCCATTGT
CAGCTCATCGGCACCATCTTCACGTGCGTGGGCATCACCACTCTCATCCAGACCACCGTG
GGCATCCGGCTGCCGCTGTTCCAGGCCAGTGCCTTTGCATTTCTGGTTCCAGCCAAAGCC
ATACTGGCTCTGGAGAGATGGAAATGCCCCCCGGAAGAGGAGATCTACGGTAACTCCAGT
CTGCCCCTGAACACCTCTCATATTTGGCACCCACGGAATCGGGAGGTCCAGGGTGCAATC
ATGGTGTCCAGCGTGGTGGAGGTGGTGATTGGCCTGCTGGGGCTGCCTGGGGCCCTGCTC
AACTCACTTGGGCCTCTCACAGTCACCCCCACTGTCTCCCTCATTGGCCTTTCTGTCTTC
CAAGCTGCTGGCGACCGACCTGGCTCCCACTGGGGCATCTCAGCTTGCTCCATTCTCCTG
ATCATCCTCTTCTCCCAGTACCTGCGCAACCTCACCTTCCTGCTGCCTGTCTACCGCTGG
GGCAAGGGGCTCACTCTCCTCCGCATCCAGATCTTCAAAATGTTTCCTATCATGCTGGCC
ATCATGACCGTGTGGCTGCTCTGCATTGTCCTGACCTTGACAGACGTGCTGCCCACAGAC
CCAAAAGCCATTGGCTTCCAGGCACGAACCGATGCCCGTGGTGACATCATGGCTATTGCA
CCCTGGATCCGCATCCCCTACCCCTGTCAGTGGGGCCTGCCCACGGTGACTGCGGCTGCT
GTCCTGGGAATGTTCAGCGCCACTCTGGCAGGCATCATTGAGTCCATCGGAGATTACTAC
GCCTGTGCCCGCCTGGCTGGTGCACCACCCCCTCCAGTACATGCTATCAACAGGGGCATC
TTCACCGAAGGCATTTGCTGCATCATCGCGGGGCTATTGGGCACGGGCAACGGGTCCACC
TCGTCCAGTCCCAACATTGGCGTCCTGGGAATTACCAAGGTGGGCAGCCGGCGCGTGGTG
CAGTATGGTGCGGCTATCATGCTGGTCCTGGGCACCATCGGCAAGTTCACGGCCCTCTTC
GCCTCGCTCCCTGACCCCATCCTGGGGGGCATGTTCTGCAGTCTCTTTGGCATGATTACA
GCTGTGGGGCTGTCCAACCTGCAATTTGTGGCACTGAACTCCTCTCGCAACCTCTTCGTG
CTGGGATTTTCCATGTTCTTCGGGCTCACGCTGCCCAATTACCTGGAGTCCAACCCTGGC
GCCATCAATACAGGCATTCTTGAAGTGGATCAGATTCTGATTGTGCTGCTGACCACGGAG
ATGTTTGTGGGCGGGTGCCTTGCTTTCATACTTGACAACACAGTGCCAGGGAGCCCAGAG
GAGCGTGGTCTGATACAGTGGAAAGCTGGGGCTCATGCCAACAGTGACATGTCTTCCAGC
CTGAAGAGCTACGATTTCCCATTTGGGATGGGCATAGTAAAAAGAATTACCTTTCTGAAA
TACATTCCTATCTGCCCAGTCTTCAAAGGATTTTCTTCAAGTTCAAAAGATCAGATTGCA
ATTCCAGAAGACACTCCAGAAAATACAGAAACTGCATCTGTGTGCACCAAGGTCTGA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
AF058317

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_3_Locus:
5q31.2-q31.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs33972313; rs35817838; rs34521685; rs6886922; rs6596473; rs6876106; rs4257763; rs11950646; rs34277728; rs34686550; rs34494316; rs11242461; rs34302647; rs34063983; rs35721934; rs10063949; rs10056051; rs6596475; rs11242462; rs6596474; rs6874871; rs36035698; rs4274973; rs34167885; rs35559224; rs35252089; rs7380761; rs10058794; rs12514667; rs10065460; rs34460201; rs34557273; rs35074020; rs11744917; rs12515989; rs6596476; rs5871697; rs34054084; rs10063870; rs1063853; rs1063910; rs11743760; rs11954417; rs3763018; rs3828601; rs3898166; rs3898167; rs4509014; rs6596471; rs7448941; rs9327846; rs9327847

# Macromolecular_Interacting_Partner_3_General_References:
9804989; 10556483; 10556521; 10631088; 11584081; 11396616

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
8682

# Macromolecular_Interacting_Partner_4_Name:
Solute carrier family 23 member 2

# Macromolecular_Interacting_Partner_4_Synonyms:
Sodium-dependent vitamin C transporter 2; hSVCT2; Na(+/L-ascorbic acid transporter 2; Yolk sac permease-like molecule 2; Nucleobase transporter-like 1 protein

# Macromolecular_Interacting_Partner_4_Gene_Name:
SLC23A2

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Solute carrier family 23 member 2
MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIY
TTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAV
PFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAIL
SLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLK
YIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSK
KGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAP
WFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIF
VEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFA
SLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLV
TGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMES
YNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
650

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
70338

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
7.74

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
 Function:  transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Nucleotide transport and metabolism

# Macromolecular_Interacting_Partner_4_Specific_Function:
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00860:Xan_ur_permease

# Macromolecular_Interacting_Partner_4_Signals:
1-333

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
103-123
140-160
162-182
219-239
242-262
267-287
313-333
372-392
462-482
486-506
514-534
548-568

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
3789789

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
S23A2_HUMAN (Q9UGH3)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SLC23A2

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SLC23A2

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10973

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1953 bp
ATGATGGGTATTGGTAAGAATACCACATCCAAATCAATGGAGGCTGGAAGTTCAACAGAA
GGCAAATACGAAGACGAGGCAAAGCACCCAGCTTTCTTCACTCTTCCGGTGGTGATAAAT
GGAGGCGCCACCTCCAGCGGTGAGCAGGACAATGAGGACACTGAGCTCATGGCGATCTAC
ACTACGGAAAACGGCATTGCAGAAAAGAGCTCTCTCGCTGAGACCCTGGATAGCACTGGC
AGTCTGGACCCCCAGCGATCAGACATGATTTATACCATAGAAGATGTTCCTCCCTGGTAC
CTGTGTATATTTCTGGGGCTACAGCACTACCTGACATGCTTCAGCGGCACGATCGCAGTG
CCCTTCCTGTTGGCCGATGCCATGTGTGTGGGGTACGACCAGTGGGCCACCAGCCAGCTC
ATTGGGACCATTTTCTTCTGTGTGGGAATCACTACTTTGCTACAGACAACGTTTGGATGC
AGGTTACCCCTGTTTCAGACCAGTGCTTTTGCATTTTTGGCCCCTGCTCGAGCCATCCTG
TCTTTAGATAAATGGAAATGTAACACCACAGATGTTTCAGTTGCCAATGGAACAGCAGAG
CTGTTGCACACAGAACACATCTGGTATCCCCGGATCCGAGAGATCCAGGGGGCCATCATC
ATGTCCTCACTGATAGAAGTAGTCATCGGCCTCCTCGGCCTGCCTGGGGCTCTACTGAAG
TACATCGGTCCCTTGACCATTACACCCACGGTGGCCCTAATTGGCCTCTCTGGTTTCCAG
GCAGCGGGGGAGAGAGCCGGGAAGCACTGGGGCATTGCCATGCTGACAATATTCCTAGTA
TTACTGTTTTCTCAATACGCCAGAAATGTTAAATTTCCTCTCCCGATTTATAAATCCAAG
AAAGGATGGACTGCGTACAAGTTACAGCTGTTCAAAATGTTCCCTATCATCCTGGCCATC
CTGGTATCCTGGCTGCTCTGCTTCATCTTCACGGTGACAGATGTCTTCCCTCCCGACAGC
ACAAAGTATGGCTTCTATGCTCGCACAGATGCCAGGCAAGGCGTGCTTCTGGTAGCCCCG
TGGTTTAAGGTTCCATACCCATTTCAGTGGGGACTGCCCACCGTGTCTGCGGCCGGTGTC
ATCGGCATGCTCAGTGCCGTGGTCGCCAGCATCATCGAGTCTATTGGTGACTACTACGCC
TGTGCACGGCTGTCCTGTGCCCCACCCCCCCCCATCCACGCAATAAACAGGGGAATTTTC
GTGGAAGGCCTCTCCTGTGTTCTTGATGGCATATTTGGTACTGGGAATGGCTCTACTTCA
TCCAGTCCCAACATTGGAGTTTTGGGAATTACAAAGGTCGGCAGCCGCCGCGTGATACAG
TGCGGAGCAGCCCTCATGCTCGCTCTGGGCATGATCGGGAAGTTCAGCGCCCTCTTTGCG
TCCCTTCCGGATCCTGTGCTGGGAGCCCTGTTCTGCACGCTCTTTGGAATGATCACAGCT
GTTGGCCTCTCTAACCTGCAGTTCATTGATTTAAATTCTTCCCGGAACCTCTTTGTGCTT
GGATTTTCGATCTTCTTTGGGCTCGTCCTTCCAAGTTACCTCAGACAGAACCCTCTGGTC
ACAGGGATAACAGGAATCGATCAAGTGTTGAACGTCCTTCTCACAACTGCTATGTTTGTA
GGGGGCTGTGTGGCTTTTATCCTGGATAACACCATCCCAGGCACTCCAGAGGAAAGAGGA
ATCCGGAAATGGAAGAAGGGTGTGGGCAAAGGGAACAAATCACTCGACGGCATGGAGTCG
TACAATTTGCCATTTGGCATGAACATTATAAAAAAATACAGATGCTTCAGCTACTTACCC
ATCAGCCCAACCTTTGTGGGCTACACATGGAAAGGCCTCAGGAAGAGCGACAACAGCCGG
AGTTCAGATGAAGACTCCCAGGCCACGGGATAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
AF058319

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:20

# Macromolecular_Interacting_Partner_4_Locus:
20p13

# Macromolecular_Interacting_Partner_4_SNPs:
rs1776964; rs1110277; rs35550945; rs34460747; rs34073337; rs34568477; rs1776948; rs1519862; rs1715395; rs1131382; rs1776947; rs6053022; rs1279683; rs6053018; rs2681118; rs6139601; rs7267986; rs4815759; rs6139587; rs2681117; rs1879176; rs6139593; rs1554379; rs4813726; rs1628664; rs3914810; rs2748897; rs6053005; rs6053021; rs6052988; rs1543452; rs4813725; rs1519864; rs6053019; rs1879177; rs1776979; rs2064842; rs6052937; rs6038025; rs1776950; rs7263163; rs6116600; rs16990455; rs6053012; rs1519860; rs11904987; rs2423086; rs6037991; rs2681116; rs6052994; rs16990314; rs6053017; rs6053003; rs1776982; rs6052995; rs2748901; rs2748899; rs2423079; rs7260796; rs6038038; rs6053016; rs1519861; rs6052974; rs12479919; rs1519865; rs6052996; rs1969715; rs16990312; rs6052984; rs2423084; rs4076098; rs6037992; rs6107559; rs6053020; rs13037458; rs6139606; rs6052997; rs1715392; rs7273306; rs1715360; rs16990309; rs1401828; rs6052936; rs6139568; rs2681110; rs6038022; rs6116605; rs6053024; rs1519866; rs6139591; rs12625071; rs6052998; rs6053030; rs16990301; rs2423085; rs12626128; rs6052993; rs6052972; rs3761240; rs13042903; rs1776954; rs6052935; rs2326576; rs6084957; rs35618917; rs6038016; rs1715361; rs1299655; rs6038020; rs12625464; rs34495360; rs2681113; rs34153342; rs6052990; rs6052981; rs35326200; rs12626067; rs34950233; rs6052991; rs6052999; rs2423076; rs2203907; rs6116596; rs35904898; rs1519867; rs12480138; rs6084944; rs6139600; rs1776952; rs7269939; rs6053006; rs11697446; rs34508882; rs6053013; rs7267995; rs35524897; rs35560557; rs6133183; rs6052992; rs35731094; rs6116606; rs13042023; rs2423077; rs35653337; rs6084953; rs6053002; rs6076757; rs8120319; rs6052970; rs2203908; rs1343095; rs16990453; rs6038017; rs1715396; rs6076763; rs6139588; rs34295827; rs2423082; rs6053010; rs6038023; rs34408933; rs6133178; rs11908556; rs1923094; rs6053008; rs11907992; rs34747363; rs6139592; rs6133182; rs35916431; rs1776953; rs2748898; rs6038027; rs6053011; rs6053001; rs1971573; rs2946682; rs1715397; rs12481301; rs6038026; rs2423083; rs1279682; rs2681114; rs17340965; rs6038021; rs6133181; rs6053029; rs6139609; rs6116608; rs34348255; rs2254964; rs1715372; rs1776955; rs1776956; rs1715378; rs1715366; rs1776957; rs1715367; rs2681107; rs1715380; rs2298174; rs1715381; rs1715364; rs1715376; rs1891649; rs1776963; rs1715385; rs1629176; rs1776960; rs6037994; rs1715379; rs1715382; rs11699954; rs4987220; rs6084932; rs6052943; rs3848824; rs1715365; rs1715386; rs1776962; rs3787455; rs12329577; rs6052954; rs6116569; rs4815755; rs4987219; rs1776965; rs6107542; rs6133175; rs4813723; rs2275783; rs6107546; rs1715384; rs1614554; rs6038005; rs6052956; rs3787458; rs6116558; rs1715373; rs3787459; rs17339942; rs11905515; rs11696241; rs3787456; rs8122118; rs6038007; rs8115867; rs6037998; rs2748896; rs12481275; rs1715362; rs6107541; rs6116565; rs1776959; rs8125299; rs3787457; rs939258; rs3787470; rs1715375; rs11907533; rs6116571; rs8126036; rs8125804; rs6052961; rs8114176; rs6038003; rs1776977; rs3737321; rs17339921; rs1776970; rs6038010; rs6052946; rs7263731; rs1715374; rs11698817; rs1935972; rs1776968; rs11907979; rs1832978; rs8125856; rs1776958; rs6116566; rs8123436; rs6052942; rs6116556; rs8124137; rs1715368; rs7265456; rs1776972; rs4813724; rs12105993; rs6052962; rs6116562; rs34702220; rs6052958; rs16990338; rs1776966; rs34132722; rs6116557; rs34993852; rs6116568; rs939257; rs35861107; rs6038011; rs1776973; rs6116559; rs11905445; rs13044374; rs1715383; rs6084918; rs17254239; rs1715371; rs11696721; rs1715363; rs1715387; rs4815754; rs6038004; rs6038002; rs13045713; rs4278995; rs35521555; rs6116570; rs8125737; rs34989880; rs6052950; rs11906868; rs16990350; rs16990317; rs1715370; rs6084933; rs1776961; rs8118604; rs33912998; rs35933069; rs6052941; rs17254623; rs6084920; rs11699324; rs2875965; rs1776967; rs17339746; rs6107547; rs3787469; rs6107545; rs36092232; rs1715377; rs6116567; rs8116601; rs7273438; rs6052949; rs6515964; rs12625874; rs12625078; rs6084959; rs7354664; rs2298173; rs41282100; rs34068132; rs34815279; rs35429615; rs11471369; rs12625783; rs36166773; rs6116586; rs6107560; rs6052987; rs2681112; rs6139599; rs11483735; rs6107563; rs35181918; rs11087663; rs11480214; rs6139608; rs12481495; rs6052969; rs36060486; rs34026255; rs35050366; rs1715394; rs6053000; rs6052975; rs6139611; rs35123258; rs6133184; rs6139586; rs34039922; rs6133179; rs7509166; rs33920836; rs6084956; rs6053007; rs34198373; rs11470987; rs6084939; rs3055956; rs6038036; rs7351148; rs34148722; rs11482615; rs34081931; rs6084958; rs6076765; rs10634743; rs6084948; rs36093605; rs7343820; rs6139590; rs6084952; rs34115530; rs2423078; rs6116607; rs6116603; rs6052971; rs35133806; rs13039880; rs7344232; rs7351669; rs34066480; rs6053028; rs2748905; rs2748904; rs11389980; rs11484083; rs35506258; rs35546835; rs6076758; rs11295599; rs6053027; rs6076759; rs34113914; rs1776951; rs35716452; rs6133180; rs6084916; rs36107804; rs4270422; rs35758430; rs34200051; rs35951917; rs2681111; rs34563130; rs2423081; rs6052985; rs6038031; rs35724620; rs1544045; rs11476705; rs35838565; rs7362712; rs6116598; rs6076761; rs34182294; rs35627245; rs13039899; rs6116593; rs6038019; rs11697164; rs34330456; rs13039517; rs6107558; rs11482448; rs36119942; rs13039282; rs6052978; rs6139598; rs1105838; rs7347969; rs11482034; rs13045405; rs2681115; rs6052989; rs34386903; rs7268804; rs6116602; rs6084940; rs35093137; rs41279442; rs6038035; rs6052980; rs6107564; rs11477394; rs35773321; rs13039857; rs6076766; rs6084947; rs35872510; rs7266587; rs11470317; rs6053026; rs35705776; rs11474681; rs11483936; rs6052979; rs6116590; rs6084943; rs11469774; rs34741335; rs6139595; rs11475838; rs10571189; rs35263820; rs11407994; rs4815756; rs2681108; rs2681109; rs13037855; rs6116587; rs35983102; rs10639211; rs34444485; rs34072253; rs7360681; rs33948580; rs6053009; rs6076762; rs10565827; rs6053025; rs33919618; rs11474342; rs11479614; rs11472482; rs33968763; rs3055922; rs34831448; rs12105990; rs8122900; rs11467487; rs6116584; rs6116599; rs34676568; rs34264067; rs11453508; rs13042680; rs6116594; rs6139604; rs6053031; rs11479811; rs35690228; rs6139583; rs36232509; rs10544474; rs35636166; rs6139594; rs2748902; rs34736998; rs2423080; rs1776981; rs11406406; rs11355760; rs11484117; rs6038030; rs11087665; rs6107556; rs35939096; rs6084942; rs12626153; rs6116553; rs2748900; rs35150774; rs3055958; rs6084917; rs6052938; rs6084949; rs34517267; rs35710976; rs2875978; rs8117200; rs6084954; rs13039303; rs6038018; rs7344484; rs11476601; rs11481639; rs6139589; rs34575753; rs7347341; rs11271718; rs11698148; rs6076764; rs4815757; rs6084955; rs6052934; rs6116595; rs11699437; rs34039314; rs34479327; rs34602551; rs6139610; rs35785559; rs6133185; rs6052976; rs6116588; rs6053015; rs13042159; rs11482505; rs35434421; rs6139605; rs6139602; rs35893158; rs35216569; rs13044231; rs1776978; rs6052983; rs4815760; rs3055921; rs6116601; rs8184698; rs11445561; rs34519143; rs6116585; rs34257293; rs35258524; rs6107557; rs10590453; rs6139585; rs35887804; rs6084951; rs6052977; rs6084941; rs1715393; rs2203906; rs6133177; rs11478053; rs6116592; rs35126993; rs12625385; rs6139603; rs6116597; rs10684173; rs11468338; rs36204798; rs11407993; rs6107561; rs11473512; rs35296546; rs6139584; rs6116589; rs6053014; rs35665533; rs35644296; rs34563953; rs13044890; rs4815758; rs35772595; rs6076755; rs35350494; rs35439649; rs6107553; rs6107548; rs6107550; rs6038012; rs11470418; rs11353402; rs6052952; rs34342291; rs11476253; rs11475191; rs6139581; rs6038006; rs11475731; rs5840058; rs35770104; rs6052955; rs2000246; rs6116572; rs6139577; rs6076747; rs33911734; rs11379695; rs6139570; rs6116555; rs6107549; rs11474285; rs6084926; rs2000245; rs6076751; rs11482735; rs34423826; rs6037995; rs6139574; rs7272986; rs9679961; rs6133176; rs4815753; rs35581026; rs35472475; rs6038000; rs6052968; rs11474495; rs1715369; rs35696861; rs6052947; rs34857934; rs6139573; rs3831355; rs6116554; rs6037993; rs1776969; rs6084936; rs7267316; rs6084930; rs6052945; rs34454908; rs34791882; rs6038015; rs6107551; rs11087662; rs6052951; rs9679790; rs35652886; rs6139576; rs35810005; rs6116561; rs6052959; rs6084937; rs6076748; rs11476599; rs11357881; rs6084929; rs6139582; rs16990319; rs11468735; rs6116564; rs6038008; rs7351192; rs1965445; rs7360072; rs3848825; rs6107554; rs35697484; rs35720329; rs36084071; rs35259157; rs6037997; rs6052944; rs35471145; rs6052939; rs11474556; rs6084925; rs6052965; rs6133172; rs34930002; rs35119293; rs6116582; rs6116579; rs35807926; rs12479984; rs6038001; rs35690852; rs11478264; rs2153967; rs41282104; rs6139569; rs35589475; rs34851677; rs1715388; rs35698334; rs11087661; rs7360110; rs11462307; rs6076749; rs12329596; rs6084938; rs2000248; rs6052953; rs34825834; rs6139579; rs6139572; rs7360092; rs35518083; rs6076754; rs35537410; rs35662510; rs11472731; rs6052948; rs6038014; rs34096124; rs6084931; rs6052960; rs6133174; rs35831646; rs6052967; rs6107543; rs6116563; rs6084928; rs6116581; rs35013259; rs11478254; rs35642385; rs11478988; rs6084924; rs35783969; rs3055035; rs11698507; rs35844701; rs35817778; rs3848826; rs11484363; rs6052964; rs13044373; rs11476144; rs3838044; rs7343946; rs939259; rs1113249; rs36004665; rs1776971; rs11467759; rs2000247; rs6084927; rs13037457; rs6133173; rs10537355; rs34483634; rs6139578; rs6139580; rs6139571; rs35229776; rs34817640; rs35881880; rs6076756; rs5840059; rs8123938; rs11474324; rs11479586; rs6052966; rs35101057; rs1539516; rs6037999; rs11431527; rs34853888; rs6052957; rs13043283; rs34292445; rs6116577; rs6038009; rs6116580; rs36040597; rs41282106; rs6139575; rs6037996; rs6107544; rs6076746; rs34104667; rs34651616; rs6052963; rs7360077; rs6107540; rs35519362; rs41282102; rs3848827; rs6076753; rs34779913; rs34953915; rs35749892; rs6084934; rs10536260; rs11482734; rs11478222; rs6116551; rs11087667; rs34618933; rs6133171; rs6139612; rs6037990; rs6084960; rs7352940; rs6037989; rs35031870; rs6076745; rs8115580; rs11467247; rs11290761; rs11469364; rs34330388; rs33990681; rs35688103; rs13037041; rs6116552; rs6133170; rs11469365; rs35708304; rs13042717; rs2423073; rs6037988; rs6053034; rs6084910; rs6116549; rs7262788; rs8119069; rs8126456

# Macromolecular_Interacting_Partner_4_General_References:
9804989; 10471399; 10556521; 10395795; 11396616; 9039502; 12168954; 11780052

# Macromolecular_Interacting_Partner_4_References:
Not Available

# Macromolecular_Interacting_Partner_5_ID:
8799

# Macromolecular_Interacting_Partner_5_Name:
Monooxygenase, DBH-like 1

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
MOXD1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Monooxygenase, DBHlike 1
MNSFLSVFRYPDFSFPYFPQDYFTNANRELKKDAQQDYHLEYAMENSTHTIIEFTRELHT
CDINDKSITDSTVRVIWAYHHEDAGEAGPKYHDSNRGTKSLRLLNPEKTSVLSTALPYFD
LVNQDVPIPNKDTTYWCQMFKIPVFQEKHHVIKVEPVIQRGHESLVHHILLYQCSNNFND
SVLESGHECYHPNMPDAFLTCETVIFAWAIGGEGFSYPPHVGLSLGTPLDPHYVLLEVHY
DNPTYEEGLIDNSGLRLFYTMDIRKYDAGVIEAGLWVSLFHTIPPGMPEFQSEGHCTLEC
LEEALEAEKPSGIHVFAVLLHAHLAGRGIRLRHFRKGKEMKLLAYDDDFDFNFQEFQYLK
EEQTILPGDNLITECRYNTKDRAEMTWGGLSTRSEMCLSYLLYYPRINLTRCASIPDIME
QLQFIGVKEIYRPVTTWPFIIKSPKQYKNLSFMDAMNKFKWTKKEGLSFNKLVLSLPVNV
RCSKTDNAEWSIQGMTALPPDIERPYKAEPLVCGTSSSSSLHRDFSINLLVCLLLLSCTL
STKSL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
545

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
62701

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.01

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
 Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Function:  dopamine beta-monooxygenase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid derivative metabolism
Process:  biogenic amine metabolism
Process:  catecholamine metabolism
 ||
>>>
 Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF03712:Cu2_monoox_C
PF01082:Cu2_monooxygen

# Macromolecular_Interacting_Partner_5_Signals:
Not Available

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
56202500

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
Q5THU6_HUMAN (Q5THU6)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
MOXD1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
MOXD1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:21063

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1179 bp
GTTGAGCCAGTGATACAGAGAGGCCATGAGAGTCTGGTGCACCACATCCTGCTCTATCAG
TGCAGCAACAACTTTAACGACAGCGTTCTGGAGTCCGGCCACGAGTGCTATCACCCCAAC
ATGCCCGATGCATTCCTCACCTGTGAAACTGTGATTTTTGCCTGGGCTATTGGTGGAGAG
GGCTTTTCTTATCCACCTCATGTTGGATTATCCCTTGGCACTCCATTAGATCCGCATTAT
GTGCTCCTAGAAGTCCATTATGATAATCCCACTTATGAGGAAGGCTTAATAGATAATTCT
GGACTGAGGTTATTTTACACAATGGATATAAGGAAATATGATGCTGGGGTGATTGAGGCT
GGCCTCTGGGTGAGCCTCTTCCATACCATCCCTCCAGGGATGCCTGAGTTCCAGTCTGAG
GGTCACTGCACTTTGGAGTGCCTGGAAGAGGCTCTGGAAGCCGAAAAGCCAAGTGGAATT
CATGTGTTTGCTGTTCTTCTCCATGCTCACCTGGCTGGCAGAGGCATCAGGCTGCGTCAT
TTTCGAAAAGGGAAGGAAATGAAATTACTTGCCTATGATGATGATTTTGACTTCAATTTC
CAGGAGTTTCAGTATCTAAAGGAAGAACAAACAATCTTACCAGGAGATAACCTAATTACT
GAGTGTCGCTACAACACGAAAGATAGAGCTGAGATGACTTGGGGAGGACTAAGCACCAGG
AGTGAAATGTGTCTCTCATACCTTCTTTATTACCCAAGAATTAATCTTACTCGATGTGCA
AGTATTCCAGACATTATGGAACAACTTCAGTTCATTGGGGTTAAGGAGATCTACAGACCA
GTCACGACCTGGCCTTTCATTATCAAAAGTCCCAAGCAATATAAAAACCTTTCTTTCATG
GATGCTATGAATAAGTTTAAATGGACTAAAAAGGAAGGTCTCTCCTTCAACAAGCTGGTC
CTCAGCCTGCCAGTGAATGTGAGATGTTCCAAGACAGACAATGCTGAGTGGTCGATTCAA
GGAATGACAGCATTACCTCCAGATATAGAAAGACCCTATAAAGCAGAACCTTTGGTGTGT
GGCACGTCTTCTTCCTCTTCCCTGCACAGAGATTTCTCCATCAACTTGCTTGTTTGCCTT
CTGCTACTCAGCTGCACGCTGAGCACCAAGAGCTTGTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
AL023578

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6q23.1-23.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
Not Available

# Macromolecular_Interacting_Partner_5_References:
Not Available

End of HMDB00044

Beginning of HMDB00045
# Accession_No:
HMDB00045

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 13:11:19

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenosine monophosphate

# Description:
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP can be produced during ATP synthesis by the enzyme adenylate kinase. AMP has recently been approved as a 'Bitter Blocker' additive to foodstuffs. When AMP is added to bitter foods or foods with a bitter aftertaste it makes them seem   'sweeter'.  This potentially makes lower calorie food products more palatable

# Synonyms:
5'-AMP; 5'-adenosine monophosphate; 5'-adenylate; 5'-adenylic acid; AMP; Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine 5'-phosphorate; Adenosine 5'-phosphoric acid; Adenosine phosphate; Adenosine-5'-monophosphorate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphorate; Adenosine-5-monophosphoric acid; Adenovite; Adenylate; Adenylic acid; Cardiomone; Lycedan; Muscle adenylate; Muscle adenylic acid; My-B-Den; Phosaden; Phosphaden; Phosphentaside; adenosine-monophosphate; adenosine-phosphate; My-beta-Den

# Chemical_IUPAC_Name:
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid

# Chemical_Formula:
C10H14N5O7P

# Chemical_Structure:
tbl_chemical:::HMDB00045_ZOOM.png:::119283153184821191

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00045_THUMB.png:::119283152969282657

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; phosphoric acid ester; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminoacyl-tRNA biosynthesis; Component of Arginine and proline metabolism; Component of Biotin metabolism; Component of Fatty acid metabolism; Component of Glutamate metabolism; Component of Glycine, serine and threonine metabolism; Component of Histidine metabolism; Component of Lysine biosynthesis; Component of Methionine metabolism; Component of Nitrogen metabolism; Component of Phenylalanine, tyrosine and tryptophan biosynthesis; Component of Porphyrin and chlorophyll metabolism; Component of Propanoate metabolism; Component of Purine metabolism; Component of Pyrimidine metabolism; Component of Pyruvate metabolism; Component of Selenoamino acid metabolism; Component of Sulfur metabolism; Component of Thiamine metabolism; Component of Tryptophan metabolism; Component of Valine, leucine and isoleucine biosynthesis

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
347.06308

# Molecular_Weight_Avg:
347.22125

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC(COP(O)(O)=O)C(O)C3O

# KEGG_Compound_ID:
C00020

# BioCyc_ID:
AMP

# PubChem_CID:
6083

# PubChem_SID:
11538455; 828450; 836432; 10322529; 831601; 854574; 830458; 836112; 584487; 11486108; 836581; 11109937; 833159; 3131852; 833690; 832885; 10322530; 10322141; 11110215; 7886002; 831649; 11466384; 7885576; 583977; 584452; 838177; 829938; 855346; 832329; 832865; 10584902; 834879; 8025337; 8028526; 836514; 837323; 584776; 585427; 8153801; 855061; 584422; 828448; 830720; 838251; 854578; 834397; 828368; 584440; 585299; 827983; 583923; 838656; 584442; 10317426; 8024258; 583720; 10317432; 841545; 828361; 828458; 838245; 828899; 838945; 7885868; 584455; 11110211; 11109936; 854624; 830875; 831651; 831590; 832127; 7853713; 828366; 11467504; 834616; 828365; 855059; 838654; 584571; 11567806; 829825; 11110505; 174663; 832477; 8028095; 830789; 8145706; 11110499; 8028180; 855182; 854577; 8021128; 837134; 838977; 10322918; 833361; 8026909; 832884; 148970

# OMIM_ID:
102770; 103000

# Metagene_ID:
Not Available

# BiGG_ID:
33534

# Wikipedia_ID:
Adenosine monophosphate

# METLIN_ID:
5111

# Ref_ID:
15882454; 13654353; 6304612; 1781403; 184364; 14965188; 15937757; 4155962; 6656991; 201957

# ChEBI_ID:
16027

# CAS_Registry_Number:
61-19-8

# InChI:
InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
195 oC

# Melting_Point_predicted:
162.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
10 mg/mL at 20 oC [BEILSTEIN]; 801 mg/mL (sodium salt, HMP expt)

# H2O_Solubility_Predicted:
3.31 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.12 [Predicted by ALOGPS]; -3.1 [Predicted by PubChem via XLOGP]; -1.68 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C00020.mol:::1132723803281681232

# SDF_File_[Text]:
tbl_chemical:::HMDB00045.sdf:::119283152513315763

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00045.pdb:::119283152796628327

# PDB_ID:
12AS

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::12AS.txt:::1132720900031335382

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_presat.png:::114807184473291564

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_presat.zip:::114807223635179858

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
tbl_hnmrs:::050106_P00_08_IS_1DP_Assigned.png:::115635152347724532

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004.png:::114807633954431682

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004.zip:::114807633955157188

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050106_P00_08_IS_2DHSQC_1004_Assigned.png:::116199095478524546

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Adenosine 5'-monophosphate.gif:::1132732102500775595

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00045_peaks.txt:::115630950906152240

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Adenosine 5'-monophosphate_C.gif:::1132737666951461387

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00045_peaks.txt:::115631070065685825

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000005.png:::116890821710964723

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000005.txt:::116890821710912563

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000005.png:::11689082168759998

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000005.txt:::116890821710961753

# Cellular_Location:
Cytoplasm (Predicted from LogP); Nucleus; endoplasmic reticulum; Extracellular; golgi apparatus; lysosome; mitochondria; peroxisome

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm

# Concentration_[Normal]:
Blood	51.0 (10.0-92.0)	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	14.0 +/- 3.0	umol/L	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	6.2	uM	Adult:>18_yrs_old	Male	Normal	13654353
Blood	5.1	uM	Adult:>18_yrs_old	Female	Normal	13654353
Cerebrospinal_Fluid(CSF)	< 0.2	uM	Adult:>18_yrs_old	Both	Normal	6656991
Cellular_Cytoplasm	80.0 (71.0-89.0)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454
Cellular_Cytoplasm	23	uM	Adult:>18_yrs_old	Both	Normal	1781403


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Bronchial Hyperresponsiveness; Coronary Artery Disease

# Pathway_Names:
Purine metabolism;Starch and sucrose metabolism;Nicotinate and nicotinamide metabolism;Pantothenate and CoA biosynthesis;Porphyrin and chlorophyll metabolism;Fatty acid metabolism;Alanine and aspartate metabolism;Valine, leucine and isoleucine biosynthesis;Methionine metabolism;Glycolysis;Pyruvate metabolism;Propanoate metabolism;Reductive carboxylate cycle (CO2 fixation)

# Pathway_Images:
Purine_Synthesis.jpg;;Nicotinamide_synthesis_(NADH).jpg;;;;Aspartate_and_Alanine_metabolism.jpg;Valine,leucine,and_isoleucine_biosynthesis.jpg;Methionine_Metabolism.jpg;Glycolysis.jpg;;;

# KEGG_Images:
map00230;map00500;map00760;map00770;map00860;map00071;map00252;map00290;map00271;map00010;map00620;map00640;map00720

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;;Nicotinamide_synthesis_(NADH)_Graph.jpg;;;;Aspartate_and_Alanine_metabolism_Graph.jpg;Valine,leucine,and_isoleucine_biosynthesis_Graph.jpg;Methionine_Metabolism_Graph.jpg;Glycolysis_Graph.jpg;;;

# Pathway_SBMLs:
Purine_Synthesis.xml;;Nicotinamide_synthesis_(NADH).xml;;;;Aspartate_and_Alanine_metabolism.xml;Valine,leucine,and_isoleucine_biosynthesis.xml;Methionine_Metabolism.xml;Glycolysis.xml;;;

# Metabolic_Enzyme_1_ID:
5832

# Metabolic_Enzyme_1_Name:
Ubiquitin-conjugating enzyme E2 A

# Metabolic_Enzyme_1_Synonyms:
Ubiquitin-protein ligase A; Ubiquitin carrier protein A; HR6A; hHR6A

# Metabolic_Enzyme_1_Gene_Name:
UBE2A

# Metabolic_Enzyme_1_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
AMSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEF
TEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPN
SPANSQAAQLYQENKREYEKRVSAIVEQSWRDC

# Metabolic_Enzyme_1_Number_of_Residues:
152

# Metabolic_Enzyme_1_Molecular_Weight:
17316

# Metabolic_Enzyme_1_Theoretical_pI:
4.79

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA

# Metabolic_Enzyme_1_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_1_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184044

# Metabolic_Enzyme_1_SwissProt_ID:
UBE2A_HUMAN (P49459)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UBE2A

# Metabolic_Enzyme_1_Geneatlas_id:
UBE2A

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12472

# Metabolic_Enzyme_1_PDB_ID:
1JAS

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>459 bp
ATGTCCACCCCGGCTCGGCGGCGCCTCATGCGGGACTTCAAGAGGTTGCAGGAGGATCCT
CCAGCCGGAGTCAGCGGGGCTCCGTCCGAGAACAACATAATGGTGTGGAACGCGGTCATT
TTCGGGCCTGAAGGGACCCCGTTTGGGGATGGAACATTTAAACTTACAATAGAATTCACT
GAAGAATATCCAAATAAACCACCTACAGTTAGATTTGTCTCTAAGATGTTCCATCCAAAT
GTCTATGCAGATGGTAGTATATGTCTGGACATACTTCAGAACCGTTGGAGTCCAACCTAT
GATGTGTCTTCCATTCTAACATCCATACAGTCTCTGTTGGATGAACCCAATCCCAATAGT
CCAGCAAACAGCCAGGCTGCTCAGCTGTACCAGGAGAACAAACGGGAATATGAAAAGCGT
GTTTCTGCAATAGTAGAACAAAGCTGGCGTGATTGTTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M74524

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xq24-q25

# Metabolic_Enzyme_1_SNPs:
rs35570533; rs35068848; rs34138874; rs5957190; rs7879933; rs6603535; rs7892285; rs7876612; rs34228798; rs5957188; rs2239005; rs35604136; rs34190757; rs5909640; rs5910619; rs35826268; rs35829336; rs4234; rs35554236; rs14982; rs1803724; rs1803723; rs35317457; rs1803722; rs1803726; rs34146345; rs1803725; rs11373415; rs33999935; rs35923694; rs12835850; rs34720011; rs34118163; rs11380086; rs5957189; rs10633866; rs34149894; rs35955727; rs12833577; rs5909639; rs35701130; rs33997434; rs5910620; rs34712158; rs35506002; rs1057043; rs35217896; rs7058905; rs34326834; rs28614024; rs28716292; rs12863747; rs34782802; rs5903559; rs34147813; rs11423460; rs3031136; rs35707286; rs12850449; rs16995567; rs16995570; rs2018358; rs2233497; rs2233498; rs4825655; rs5910616; rs5956133; rs6645577; rs6645579

# Metabolic_Enzyme_1_General_References:
1717990

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5318

# Metabolic_Enzyme_2_Name:
Ectonucleoside triphosphate diphosphohydrolase 3

# Metabolic_Enzyme_2_Synonyms:
NTPDase 3; Ecto-ATP diphosphohydrolase; ATPDase; Ecto-apyrase; CD39 antigen-like 3; HB6

# Metabolic_Enzyme_2_Gene_Name:
ENTPD3

# Metabolic_Enzyme_2_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 3
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIV
LDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKV
KGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ
EEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTS
DIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTM
GHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQ
PKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARS
YCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRL
PIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD

# Metabolic_Enzyme_2_Number_of_Residues:
529

# Metabolic_Enzyme_2_Molecular_Weight:
59106

# Metabolic_Enzyme_2_Theoretical_pI:
6.40

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Not Available

# Metabolic_Enzyme_2_Specific_Function:
Has a threefold preference for the hydrolysis of ATP over ADP

# Metabolic_Enzyme_2_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_2_Signals:
1-37

# Metabolic_Enzyme_2_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
3335100

# Metabolic_Enzyme_2_SwissProt_ID:
ENTP3_HUMAN (O75355)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ENTPD3

# Metabolic_Enzyme_2_Geneatlas_id:
ENTPD3

# Metabolic_Enzyme_2_hgnc_id:
HGNC:3365

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_2_Gene_Sequence:
>1590 bp
ATGTTCACTGTGCTGACCCGCCAACCATGTGAGCAAGCAGGCCTCAAGGCCCTCTACCGA
ACTCCAACCATCATTGCCTTGGTGGTCTTGCTTGTGAGTATTGTGGTACTTGTGAGTATC
ACTGTCATCCAGATCCACAAGCAAGAGGTCCTCCCTCCAGGACTGAAGTATGGTATTGTG
CTGGATGCCGGGTCTTCAAGAACCACAGTCTACGTGTATCAATGGCCAGCAGAAAAAGAG
AATAATACCGGAGTGGTCAGTCAAACCTTCAAATGTAGTGTGAAAGGCTCTGGAATCTCC
AGCTATGGAAATAACCCCCAAGATGTCCCCAGAGCCTTTGAGGAGTGTATGCAAAAAGTC
AAGGGGCAGGTTCCATCCCACCTCCACGGATCCACCCCCATTCACCTGGGAGCCACGGCT
GGGATGCGCTTGCTGAGGTTGCAAAATGAAACAGCAGCTAATGAAGTCCTTGAAAGCATC
CAAAGCTACTTCAAGTCCCAGCCCTTTGACTTTAGGGGTGCTCAAATCATTTCTGGGCAA
GAAGAAGGGGTATATGGATGGATTACAGCCAACTATTTAATGGGAAATTTCCTGGAGAAG
AACCTGTGGCACATGTGGGTGCACCCGCATGGAGTGGAAACCACGGGTGCCCTGGACTTA
GGTGGTGCCTCCACCCAAATATCCTTCGTGGCAGGAGAGAAGATGGATCTGAACACCAGC
GACATCATGCAGGTGTCCCTGTATGGCTACGTATACACGCTCTACACACACAGCTTCCAG
TGCTATGGCCGGAATGAGGCTGAGAAGAAGTTTCTGGCAATGCTCCTGCAGAATTCTCCT
ACCAAAAACCATCTCACCAATCCCTGTTACCCTCGGGATTATAGCATCAGCTTCACCATG
GGCCATGTATTTGATAGCCTGTGCACTGTGGACCAGAGGCCAGAAAGTTATAACCCCAAT
GATGTCATCACTTTTGAAGGAACTGGGGACCCATCTCTGTGTAAGGAGAAGGTGGCTTCC
ATATTTGACTTCAAAGCTTGCCATGATCAAGAAACCTGTTCTTTTGATGGGGTTTATCAG
CCAAAGATTAAAGGGCCATTTGTGGCTTTTGCAGGATTCTACTACACAGCCAGTGCTTTA
AATCTTTCAGGTAGCTTTTCCCTGGACACCTTCAACTCCAGCACCTGGAATTTCTGCTCA
CAGAATTGGAGTCAGCTCCCACTGCTGCTCCCCAAATTTGATGAGGTATATGCCCGCTCT
TACTGCTTCTCAGCCAACTACATCTACCACTTGTTTGTGAACGGTTACAAATTCACAGAG
GAGACTTGGCCCCAAATACACTTTGAAAAAGAAGTGGGGAATAGCAGCATAGCCTGGTCT
CTTGGCTACATGCTCAGCCTGACCAACCAGATCCCAGCTGAAAGCCCTCTGATCCGTCTG
CCCATAGAACCACCTGTCTTTGTGGGCACCCTCGCTTTCTTCACAGTGGCAGCCTTGCTG
TGTCTGGCATTTCTTGCATACCTGTGTTCAGCAACCAGAAGAAAGAGGCACTCCGAGCAT
GCCTTTGACCATGCAGTGGATTCTGACTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
AF039917

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_2_Locus:
3p21.3

# Metabolic_Enzyme_2_SNPs:
rs1047855; rs2305521; rs9858868; rs11714871; rs17078798; rs2305522; rs12493020; rs897117; rs1466236; rs6599101; rs6808095; rs9332450; rs6599102; rs954589; rs6783755; rs9848083; rs951560; rs7645864; rs7636719; rs4973999; rs9829800; rs4973997; rs4973898; rs7648952; rs12490249; rs13324109; rs17079011; rs9849348; rs9873394; rs17078941; rs17078813; rs1466237; rs7634375; rs1105745; rs7631893; rs9822909; rs9859026; rs1466238; rs7625736; rs4283549; rs17078812; rs9857824; rs6793596; rs11707673; rs11714032; rs11720360; rs6599100; rs9875245; rs2371185; rs6804157; rs17078914; rs11921197; rs17078916; rs12492035; rs4973994; rs17078921; rs4973989; rs17078959; rs13099333; rs1037516; rs12490275; rs3774805; rs4973998; rs12492777; rs6796122; rs4973993; rs13326389; rs13321169; rs12491944; rs12634013; rs13081891; rs11920596; rs9848049; rs13066971; rs12636697; rs6807397; rs9864380; rs34266806; rs4470483; rs17852714; rs3733167; rs41286046; rs35071108; rs6773917; rs10671439; rs35839072; rs35836679; rs9874499; rs10551054; rs13073943; rs10565031; rs13094752; rs10620040; rs11351492; rs34255517; rs34665572; rs3774806; rs10575365; rs5848563; rs951561; rs13082239; rs3064608; rs11445995; rs9809377; rs35636349; rs35489659; rs4560275; rs6798459; rs10620057; rs13316488; rs13082375; rs6797651; rs6795906; rs13073946; rs3064609; rs41286044; rs35641310; rs35870509; rs13082222; rs13090979; rs9836330; rs34726619; rs28465354; rs10650731; rs9883218; rs9863737; rs9829324; rs1105746; rs5848564; rs9833430; rs9880286; rs9864423; rs3774807; rs28621801; rs34065066; rs6767610; rs11415995; rs3064615; rs35700770; rs5848565; rs9882941; rs34145192; rs34654655; rs10658778; rs11360523; rs9843979; rs36074810; rs9843965; rs13072002; rs35267876; rs41286048; rs9860002; rs9863679; rs13433935; rs35860386; rs9882954; rs11371152; rs9809378; rs28671141; rs28508335; rs34934417; rs6808552; rs10594515; rs9828299; rs1119179; rs12488805; rs12492578; rs12494022; rs2371184; rs6762997; rs6795066; rs7610586; rs7616273; rs7642552; rs9813231; rs9817233; rs9822644; rs9835219; rs9841335; rs9846606; rs9871825; rs9874006; rs9882464

# Metabolic_Enzyme_2_General_References:
9676430; 9675246; 10231536; 11300774

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5833

# Metabolic_Enzyme_3_Name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_3_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_3_Gene_Name:
PDE6H

# Metabolic_Enzyme_3_Protein_Sequence:
>Retinal cone rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDI
TVICPWEAFSHLELHELAQFGII

# Metabolic_Enzyme_3_Number_of_Residues:
83

# Metabolic_Enzyme_3_Molecular_Weight:
9074

# Metabolic_Enzyme_3_Theoretical_pI:
9.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_3_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
1311544

# Metabolic_Enzyme_3_SwissProt_ID:
CNCG_HUMAN (Q13956)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
PDE6H

# Metabolic_Enzyme_3_Geneatlas_id:
PDE6H

# Metabolic_Enzyme_3_hgnc_id:
HGNC:8790

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_3_Gene_Sequence:
>252 bp
ATGAGTGACAACACTACTCTGCCTGCTCCAGCTTCAAACCAGGGTCCTACCACCCCACGC
AAAGGCCCTCCCAAGTTCAAGCAGAGGCAGACTCGCCAATTCAAGAGTAAACCTCCAAAG
AAAGGTGTGAAAGGATTTGGAGATGACATTCCAGGAATGGAGGGGCTAGGAACAGATATC
ACAGTGATTTGTCCATGGGAGGCATTCAGCCACCTGGAATTGCATGAGCTCGCTCAGTTT
GGGATTATCTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
D45399

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_3_Locus:
12p13

# Metabolic_Enzyme_3_SNPs:
rs2233628; rs10846103; rs10505783; rs12305014; rs3748304; rs11056268; rs11056266; rs11056264; rs11056267; rs10505784; rs11056265; rs11832908; rs16910453; rs16910452; rs12228166; rs12422943; rs10744079; rs12306284; rs2233623; rs2233624; rs12832328; rs2233627; rs11833894; rs10846101; rs7954788; rs4764144; rs12579539; rs2233615; rs11835506; rs7953827; rs7301508; rs11056262; rs11056263; rs12228802; rs11611992; rs2233614; rs11450989; rs11314271; rs11346506; rs12817970; rs12817527; rs12822730; rs34043026; rs35679948; rs2233626; rs2233625; rs11608901; rs11608900; rs35657741; rs4616093; rs2233619; rs2233617; rs2233618; rs2233620; rs2233616; rs34917153; rs34417895; rs2233622; rs2233621; rs10744080; rs10846096; rs10846097; rs11056256; rs11056257; rs11056258; rs11056259; rs11056260; rs11056261; rs11056269; rs11056271; rs11056272; rs11056273; rs11056274; rs11056275; rs11832957; rs11834072; rs11835380; rs11835890; rs12298310; rs12298374; rs12307651; rs12308864; rs12322752; rs12424815; rs12425797; rs12425846; rs12426974; rs12821630; rs2024506; rs2430717; rs2430718; rs2430719; rs2430720; rs2430722; rs2445431; rs36114797; rs3983696; rs4429114; rs4764145; rs4764146; rs7300467; rs7301780; rs7311989; rs7313555; rs7954364; rs7954390; rs7955907; rs7966504; rs7968954; rs7976617; rs7977013; rs7978415

# Metabolic_Enzyme_3_General_References:
8786098

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5834

# Metabolic_Enzyme_4_Name:
Adenylate kinase isoenzyme 1

# Metabolic_Enzyme_4_Synonyms:
ATP-AMP transphosphorylase; AK1; Myokinase

# Metabolic_Enzyme_4_Gene_Name:
AK1

# Metabolic_Enzyme_4_Protein_Sequence:
>Adenylate kinase isoenzyme 1
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEI
MEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDA
GPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVD
SVFSQVCTHLDALK

# Metabolic_Enzyme_4_Number_of_Residues:
194

# Metabolic_Enzyme_4_Molecular_Weight:
21635

# Metabolic_Enzyme_4_Theoretical_pI:
8.99

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  adenylate kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleoside triphosphate metabolism
Process:  purine ribonucleoside triphosphate metabolism
Process:  ATP metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
This small ubiquitous enzyme is essential for maintenance and cell growth

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_4_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
178322

# Metabolic_Enzyme_4_SwissProt_ID:
KAD1_HUMAN (P00568)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
AK1

# Metabolic_Enzyme_4_Geneatlas_id:
AK1

# Metabolic_Enzyme_4_hgnc_id:
HGNC:361

# Metabolic_Enzyme_4_PDB_ID:
1Z83

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_4_Gene_Sequence:
>585 bp
ATGGAAGAGAAGCTGAAGAAAACCAAGATCATCTTTGTGGTGGGTGGGCCTGGCTCAGGG
AAGGGCACCCAGTGTGAGAAGATCGTGCAGAAGTATGGCTACACCCACCTCTCCACCGGG
GACCTCCTGCGGTCCGAGGTCAGCTCAGGCTCGGCCAGGGGCAAGAAGCTGTCGGAAATC
ATGGAGAAGGGGCAGCTGGTTCCACTGGAGACAGTGTTGGACATGCTCCGGGATGCCATG
GTGGCCAAAGTCAATACTTCCAAAGGCTTCCTGATTGATGGCTACCCGCGGGAGGTGCAG
CAAGGAGAAGAGTTTGAGCGACGGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCA
GGCCCTGAGACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGAC
GACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAACCCGTC
ATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGAC
AGTGTCTTCTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
J04809

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_4_Locus:
9q34.1

# Metabolic_Enzyme_4_SNPs:
rs8192462; rs913987; rs4226; rs1005362; rs10987762; rs1009935; rs1556246; rs3780663; rs2094332; rs743539; rs743537; rs3780662; rs2070692; rs968463; rs913984; rs913985; rs743540; rs743538; rs7031929; rs3780661; rs2070690; rs10987766; rs2070689; rs10987765; rs6478799; rs3758323; rs3758321; rs3758322; rs7032134; rs35902264; rs913986; rs35834000; rs10987763; rs762490; rs2767397; rs11288755; rs5900774; rs34340582; rs2249308; rs2070693; rs11350563; rs2767396; rs5900775; rs762492; rs35738186; rs2767400; rs2010424; rs2767399; rs35921099; rs36059128; rs34076212; rs2767398; rs7018806; rs2070691; rs13290260; rs3842223; rs34920249; rs41305503; rs34525266; rs12342060; rs2767401; rs1009937; rs2010640; rs762491; rs7019406; rs34357982; rs2854237; rs4989853; rs2774265; rs13290737; rs2767395; rs2900257; rs2900258; rs913988; rs13291054; rs1041382; rs35534101; rs2854238; rs13291025; rs13290745; rs5900773; rs35466810; rs12339436; rs35452223; rs1053520; rs10819315; rs11998795; rs1537034; rs1887266; rs1887267; rs2031696; rs3178243; rs4837194; rs4837196; rs4837197; rs4837202; rs7865146; rs913981; rs913982; rs913983; rs9919018

# Metabolic_Enzyme_4_General_References:
183954; 2542324

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5426

# Metabolic_Enzyme_5_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

# Metabolic_Enzyme_5_Synonyms:
E- NPP 3; Phosphodiesterase I/nucleotide pyrophosphatase 3; Phosphodiesterase I beta; PD-Ibeta; CD203c antigen[Includes: Alkaline phosphodiesterase I; NPPase]

# Metabolic_Enzyme_5_Gene_Name:
ENPP3

# Metabolic_Enzyme_5_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFD
ASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCL
QKKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTL
MPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLS
SKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERIS
TLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRN
LHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNS
EEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGG
GNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLN
HLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEI
TATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPT
VPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEE
FRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHY
FVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVR
DVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI

# Metabolic_Enzyme_5_Number_of_Residues:
875

# Metabolic_Enzyme_5_Molecular_Weight:
100097

# Metabolic_Enzyme_5_Theoretical_pI:
6.55

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00500  Starch and sucrose metabolism;
 map00740  Riboflavin metabolism;
 map00760  Nicotinate and nicotinamide metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_5_Reaction:
A dinucleotide + H2O = 2 mononucleotides

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_5_Signals:
1-38

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.4.1;EC 3.6.1.9

# Metabolic_Enzyme_5_GenBank_ID_Protein:
2465540

# Metabolic_Enzyme_5_SwissProt_ID:
ENPP3_HUMAN (O14638)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
ENPP3

# Metabolic_Enzyme_5_Geneatlas_id:
ENPP3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:3358

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential). Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted protein. Note=Secreted in serum, and in lumen of epithelial cells

# Metabolic_Enzyme_5_Gene_Sequence:
>2628 bp
ATGGAATCTACGTTGACTTTAGCAACGGAACAACCTGTTAAGAAGAACACTCTTAAGAAA
TATAAAATAGCTTGCATTGTTCTTCTTGCTTTGCTGGTGATCATGTCACTTGGATTAGGC
CTGGGGCTTGGACTCAGGAAACTGGAAAAGCAAGGCAGCTGCAGGAAGAAGTGCTTTGAT
GCATCATTTAGAGGACTGGAGAACTGCCGGTGTGATGTGGCATGTAAAGACCGAGGTGAT
TGCTGCTGGGATTTTGAAGACACCTGTGTGGAATCAACTCGAATATGGATGTGCAATAAA
TTTCGTTGTGGAGAGACCAGATTAGAGGCCAGCCTTTGCTCTTGTTCAGATGACTGTTTG
CAGAAGAAAGATTGCTGTGCTGACTATAAGAGTGTTTGCCAAGGAGAAACCTCATGGCTG
GAAGAAAACTGTGACACAGCCCAGCAGTCTCAGTGCCCAGAAGGGTTTGACCTGCCACCA
GTTATCTTGTTTTCTATGGATGGATTTAGAGCTGAATATTTATACACATGGGATACTTTA
ATGCCAAATATCAATAAACTGAAAACATGTGGAATTCATTCAAAATACATGAGAGCTATG
TATCCTACCAAAACCTTCCCAAATCATTACACCATTGTCACGGGCTTGTATCCAGAGTCA
CATGGCATCATTGACAATAATATGTATGATGTAAATCTCAACAAGAATTTTTCACTTTCT
TCAAAGGAACAAAATAATCCAGCCTGGTGGCATGGGCAACCAATGTGGCTGACAGCAATG
TATCAAGGTTTAAAAGCCGCTACCTACTTTTGGCCCGGATCAGAAGTGGCTATAAATGGC
TCCTTTCCTTCCATATACATGCCTTACAACGGAAGTGTCCCATTTGAAGAGAGGATTTCT
ACACTGTTAAAATGGCTGGACCTGCCCAAAGCTGAAAGACCCAGGTTTTATACCATGTAT
TTTGAAGAACCTGATTCCTCTGGACATGCAGGTGGACCAGTCAGTGCCAGAGTAATTAAA
GCCTTACAGGTAGTAGATCATGCTTTTGGGATGTTGATGGAAGGCCTGAAGCAGCGGAAT
TTGCACAACTGTGTCAATATCATCCTTCTGGCTGACCATGGAATGGACCAGACTTATTGT
AACAAGATGGAATACATGACTGATTATTTTCCCAGAATAAACTTCTTCTACATGTACGAA
GGGCCTGCCCCCCGCATCCGAGCTCATAATATACCTCATGACTTTTTTAGTTTTAATTCT
GAGGAAATTGTTAGAAACCTCAGTTGCCGAAAACCTGATCAGCATTTCAAGCCCTATTTG
ACTCCTGATTTGCCAAAGCGACTGCACTATGCCAAGAACGTCAGAATCGACAAAGTTCAT
CTCTTTGTGGATCAACAGTGGCTGGCTGTTAGGAGTAAATCAAATACAAATTGTGGAGGA
GGCAACCATGGTTATAACAATGAGTTTAGGAGCATGGAGGCTATCTTTCTGGCACATGGA
CCCAGTTTTAAAGAGAAGACTGAAGTTGAACCATTTGAAAATATTGAAGTCTATAACCTA
ATGTGTGATCTTCTACGCATTCAACCAGCACCAAACAATGGAACCCATGGTAGTTTAAAC
CATCTTCTGAAGGTGCCTTTTTATGAGCCATCCCATGCAGAGGAGGTGTCAAAGTTTTCT
GTTTGTGGCTTTGCTAATCCATTGCCCACAGAGTCTCTTGACTGTTTCTGCCCTCACCTA
CAAAATAGTACTCAGCTGGAACAAGTGAATCAGATGCTAAATCTCACCCAAGAAGAAATA
ACAGCAACAGTGAAAGTAAATTTGCCATTTGGGAGGCCTAGGGTACTGCAGAAGAACGTG
GACCACTGTCTCCTTTACCACAGGGAATATGTCAGTGGATTTGGAAAAGCTATGAGGATG
CCCATGTGGAGTTCATACACAGTCCCCCAGTTGGGAGACACATCGCCTCTGCCTCCCACT
GTCCCAGACTGTCTGCGGGCTGATGTCAGGGTTCCTCCTTCTGAGAGCCAAAAATGTTCC
TTCTATTTAGCAGACAAGAATATCACCCACGGCTTCCTCTATCCTCCTGCCAGCAATAGA
ACATCAGATAGCCAATATGATGCTTTAATTACTAGCAATTTGGTACCTATGTATGAAGAA
TTCAGAAAAATGTGGGACTACTTCCACAGTGTTCTTCTTATAAAACATGCCACAGAAAGA
AATGGAGTAAATGTGGTTAGTGGACCAATATTTGATTATAATTATGATGGCCATTTTGAT
GCTCCAGATGAAATTACCAAACATTTAGCCAACACTGATGTTCCCATCCCAACACACTAC
TTTGTGGTGCTGACCAGTTGTAAAAACAAGAGCCACACACCGGAAAACTGCCCTGGGTGG
CTGGATGTCCTACCCTTTATCATCCCTCACCGACCTACCAACGTGGAGAGCTGTCCTGAA
GGTAAACCAGAAGCTCTTTGGGTTGAAGAAAGATTTACAGCTCACATTGCCCGGGTCCGT
GATGTAGAACTTCTCACTGGGCTTGACTTCTATCAGGATAAAGTGCAGCCTGTCTCTGAA
ATTTTGCAACTAAAGACATATTTACCAACATTTGAAACCACTATTTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF005632

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_5_Locus:
6q22

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
9344668; 14574404

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5713

# Metabolic_Enzyme_6_Name:
Beta-Ala-His dipeptidase precursor

# Metabolic_Enzyme_6_Synonyms:
Carnosine dipeptidase 1; CNDP dipeptidase 1; Serum carnosinase; Glutamate carboxypeptidase-like protein 2

# Metabolic_Enzyme_6_Gene_Name:
CNDP1

# Metabolic_Enzyme_6_Protein_Sequence:
>BetaAlaHis dipeptidase precursor
MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPVILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

# Metabolic_Enzyme_6_Number_of_Residues:
507

# Metabolic_Enzyme_6_Molecular_Weight:
56693

# Metabolic_Enzyme_6_Theoretical_pI:
4.95

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  protein dimerization activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  metallopeptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_6_Pathway:
map00340  Histidine metabolism;
 map00410  beta-Alanine metabolism

# Metabolic_Enzyme_6_Reaction:
Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF07687:M20_dimer;
PF01546:Peptidase_M20

# Metabolic_Enzyme_6_Signals:
1-26

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.4.13.20

# Metabolic_Enzyme_6_GenBank_ID_Protein:
16555792

# Metabolic_Enzyme_6_SwissProt_ID:
CNDP1_HUMAN (Q96KN2)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CNDP1

# Metabolic_Enzyme_6_Geneatlas_id:
CNDP1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:20675

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Secreted protein

# Metabolic_Enzyme_6_Gene_Sequence:
>1527 bp
ATGGATCCCAAACTCGGGAGAATGGCTGCGTCCCTGCTGGCTGTGCTGCTGCTGCTGCTG
CTGGAGCGCGGCATGTTCTCCTCACCCTCCCCGCCCCCGGCGCTGTTAGAGAAAGTCTTC
CAGTACATTGACCTCCATCAGGATGAATTTGTGCAGACGCTGAAGGAGTGGGTGGCCATC
GAGAGCGACTCTGTCCAGCCTGTGCCTCGCTTCAGACAAGAGCTCTTCAGAATGATGGCC
GTGGCTGCGGACACGCTGCAGCGCCTGGGGGCCCGTGTGGCCTCGGTGGACATGGGTCCT
CAGCAGCTGCCCGATGGTCAGAGTCTTCCAATACCTCCCGTCATCCTGGCCGAACTGGGG
AGCGATCCCACGAAAGGCACCGTGTGCTTCTACGGCCACTTGGACGTGCAGCCTGCTGAC
CGGGGCGATGGGTGGCTCACGGACCCCTATGTGCTGACGGAGGTAGGCGGGAAACTTTAT
GGACGAGGAGCGACCGACAACAAAGGCCCTGTCTTGGCTTGGATCAATGCTGTGAGCGCC
TTCAGAGCCCTGGAGCAAGATCTTCCTGTGAATATCAAATTCATCATTGAGGGGATGGAA
GAGGCTGGCTCTGTTGCCCTGGAGGAACTTGTGGAAAAAGAAAAGGACCGATTCTTCTCT
GGTGTGGACTACATTGTAATTTCAGATAACCTGTGGATCAGCCAAAGGAAGCTAGCAATC
ACTTACGGAACCCGGGGGAACAGCTACTTCATGGTGGAGGTGAAATGCAGAGACCAGGAT
TTTCACTCAGGAACCTTTGGTGGCATCCTTCATGAACTAATGGCTGATCTGGTTGCTCTT
CTCGGTAGCCTGGTAGACTCGTCTGGTCATATCCTGGTCCCTGGAATCTATGATGAAGTG
GTTCCTCTTACAGAAGAGGAAATAAATACATACAAAGCCATCCATCTAGACCTAGAAGAA
TACCGGAATAGCAGCCGGGTTGAGAAATTTCTGTTCGATACTAAGGAGGAGATTCTAATG
CACCTCTGGAGGTACCCATCTCTTTCTATTCATGGGATCGAGGGCGCGTTTGATGAGCCT
GGAACTAAAACAGTCATACCTGGCCGAGTTATAGGAAAATTTTCAATCCGTCTAGTCCCT
CACATGAATGTGTCTGCGGTGGAAAAACAGGTGACACGACATCTTGAAGATGTGTTCTCC
AAAAGAAATAGTTCCAACAAGATGGTTGTTTCCATGACTCTAGGACTACACCCGTGGATT
GCAAATATTGATGACACTCAGTATCTCGCAGCAAAAAGAGCGATCAGAACAGTGTTTGGA
ACAGAACCAGATATGATCCGGGATGGATCCACCATTCCAATTGCCAAAATGTTCCAGGAG
ATCGTCCACAAGAGCGTGGTGCTAATTCCGCTGGGAGCTGTTGATGATGGAGAACATTCG
CAGAATGAGAAAATCAACAGGTGGAACTACATAGAGGGAACCAAATTATTTGCTGCCTTT
TTCTTAGAGATGGCCCAGCTCCATTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ417564

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:18

# Metabolic_Enzyme_6_Locus:
18q22.3

# Metabolic_Enzyme_6_SNPs:
rs4263028; rs11151964; rs9807352; rs12960862; rs2887; rs4891564; rs2346064; rs1004453; rs7239132; rs12604675; rs10469123; rs10469203; rs12607796; rs12605490; rs8087768; rs9319909; rs4892246; rs7506171; rs4329999; rs7242384; rs8085167; rs11876996; rs7244370; rs7506929; rs4892243; rs7231312; rs4892242; rs12605520; rs733686; rs9967490; rs7229005; rs7232853; rs1426256; rs7506957; rs17817095; rs11875756; rs7506825; rs17817180; rs12961730; rs12964027; rs12456406; rs12964208; rs7506760; rs12956997; rs12456388; rs12964454; rs11873844; rs17817345; rs7505047; rs17089382; rs17089414; rs17089390; rs7233066; rs9953129; rs9960024; rs11659237; rs9807248; rs11662276; rs17816861; rs11873901; rs10469124; rs17089403; rs1559809; rs17817077; rs9949100; rs4891563; rs11661606; rs2881289; rs7228575; rs9957229; rs9955944; rs17089375; rs4892244; rs17089411; rs4892239; rs17238585; rs7505555; rs12326826; rs9946796; rs11876764; rs9949990; rs34570315; rs12957330; rs7506936; rs4892241; rs7506258; rs9952652; rs4355018; rs9957885; rs11664748; rs4133234; rs17238285; rs1974965; rs11659364; rs4892238; rs11875122; rs7237549; rs9948919; rs12959707; rs12457983; rs12964810; rs1974963; rs4891562; rs11873542; rs12962343; rs2881288; rs17089378; rs12954161; rs9959794; rs7504932; rs12327522; rs11664535; rs7230673; rs12455650; rs1974964; rs7244647; rs9989559; rs11875810; rs12954438; rs2098910; rs2346061; rs2346063; rs890333; rs2346062; rs2081548; rs890332; rs11538620; rs34522443; rs11538622; rs11538624; rs11538623; rs35604255; rs10533212; rs35771415; rs34713611; rs9967349; rs33922160; rs34365714; rs34526667; rs11875787; rs28448542; rs28871039; rs35084313; rs10549931; rs10685765; rs34874693; rs4891561; rs12606902; rs34117300; rs12959038; rs36228963; rs5826336; rs35735348; rs34499247; rs35885130; rs35388041; rs28713380; rs11151965; rs34138697; rs35204551; rs9966983; rs7505007; rs35096494; rs33950634; rs33981863; rs34142328; rs12959706; rs9955580; rs9947243; rs34869467; rs35788286; rs10624462; rs34283867; rs6566813; rs34962477; rs34335073; rs5826332; rs36060345; rs34573470; rs35682790; rs35362460; rs35860275; rs35365788; rs12964034; rs10522670; rs12959748; rs4892245; rs36111704; rs12969794; rs5826335; rs4891560; rs9965945; rs34070364; rs10624665; rs5826334; rs34842524; rs35877440; rs34785330; rs17089373; rs7233122; rs10596720; rs9948674; rs34189472; rs10562152; rs10649703; rs34321505; rs35707511; rs9949211; rs35368997; rs35691581; rs35734110; rs9953867; rs34563384; rs35469246; rs8087111; rs34726849; rs35932028; rs12969795; rs12969769; rs34799288; rs35234907; rs28800835; rs34646410; rs10685766; rs34895018; rs35597919; rs12961586; rs6566814; rs28877095; rs4892240; rs33911381; rs8088199; rs11872770; rs36206459; rs7350982; rs34145828; rs11447097; rs12104001; rs4892247; rs3080879; rs10663835; rs10871736; rs10871737; rs1130046; rs11664131; rs12327049; rs12456405; rs12954579; rs12966495; rs12967519; rs12970020; rs17089369; rs2114228; rs28534519; rs35248661; rs4353545; rs4891565; rs4891566; rs4892233; rs4892248; rs4892249; rs6566815; rs7238101; rs7504377; rs7506051; rs7506112; rs8096427; rs8099458; rs9319908

# Metabolic_Enzyme_6_General_References:
12975309

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5836

# Metabolic_Enzyme_7_Name:
Ubiquitin/ISG15-conjugating enzyme E2 L6

# Metabolic_Enzyme_7_Synonyms:
Ubiquitin- protein ligase L6; Ubiquitin carrier protein L6; UbcH8; Retinoic acid-induced gene B protein; RIG-B

# Metabolic_Enzyme_7_Gene_Name:
UBE2L6

# Metabolic_Enzyme_7_Protein_Sequence:
>Ubiquitin/ISG15conjugating enzyme E2 L6
MASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEY
PFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPL
RMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

# Metabolic_Enzyme_7_Number_of_Residues:
152

# Metabolic_Enzyme_7_Molecular_Weight:
17638

# Metabolic_Enzyme_7_Theoretical_pI:
8.06

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_7_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_7_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_7_GenBank_ID_Protein:
2623260

# Metabolic_Enzyme_7_SwissProt_ID:
UB2L6_HUMAN (O14933)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UBE2L6

# Metabolic_Enzyme_7_Geneatlas_id:
UBE2L6

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12490

# Metabolic_Enzyme_7_PDB_ID:
1WZW

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>459 bp
ATGGCGAGCATGCGAGTGGTGAAGGAGCTGGAGGATCTTCAGAAGAAGCCTCCCCCATAC
CTGCGGAACCTGTCCAGCGATGATGCCAATGTCCTGGTGTGGCACGCTCTCCTCCTACCC
GACCAACCTCCCTACCACCTGAAAGCCTTCAACCTGCGCATCAGCTTCCCGCCGGAGTAT
CCGTTCAAGCCTCCCATGATCAAATTCACAACCAAGATCTACCACCCCAACGTGGACGAG
AACGGACAGATTTGCCTGCCCATCATCAGCAGTGAGAACTGGAAGCCTTGCACCAAGACT
TGCCAAGTCCTGGAGGCCCTCAATGTGCTGGTGAATAGACCGAATATCAGGGAGCCCCTG
CGGATGGACCTCGCTGACCTGCTGACACAGAATCCGGAGCTGTTCAGAAAGAATGCCGAA
GAGTTCACCCTCCGATTCGGAGTGGACCGGCCCTCCTAA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AF031141

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_7_Locus:
11q12

# Metabolic_Enzyme_7_SNPs:
rs2649649; rs5847; rs2729374; rs2729372; rs4938871; rs2848621; rs1115172; rs2649650; rs2649651; rs2848624; rs2234405; rs11604188; rs1115173; rs2848623; rs4939152; rs12291920; rs3741083; rs2729375; rs7482188; rs7105312; rs4939151; rs11229057; rs10792104; rs2729373; rs10896626; rs12364489; rs2234412; rs2649656; rs2234409; rs2649655; rs2729371; rs11603817; rs2729370; rs35921478; rs1802110; rs2234408; rs3741082; rs12292224; rs2649652; rs35985517; rs11554063; rs34890600; rs1798164; rs475215; rs11605528; rs34002509; rs568190; rs2649653; rs35614262; rs2848625; rs10624657; rs35528044; rs2270765; rs34323359; rs11301277; rs11605571; rs12800738; rs35413834; rs34749631; rs2649654; rs35011093; rs11229056; rs1115174; rs11604761; rs11554065; rs35993405; rs2234406; rs2649647; rs14889; rs2234407; rs11554064; rs12800733; rs1058468; rs2649648; rs2234410; rs2234411; rs35662521; rs5792049; rs17525265; rs10680002; rs2234404; rs35789692; rs34156168; rs2234402; rs2649646; rs2234403; rs10657575; rs10629551; rs12291337; rs35305272; rs2234401; rs10792106; rs1124942; rs12223229; rs2649658; rs2729364; rs2729367; rs2729368; rs2729382; rs2848639; rs7124330

# Metabolic_Enzyme_7_General_References:
9153201; 10894956

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5837

# Metabolic_Enzyme_8_Name:
Glycyl-tRNA synthetase

# Metabolic_Enzyme_8_Synonyms:
Glycine--tRNA ligase; GlyRS

# Metabolic_Enzyme_8_Gene_Name:
GARS

# Metabolic_Enzyme_8_Protein_Sequence:
>GlycyltRNA synthetase
MPSPRPVLLRGARAALLLLLPPRLLARPSLLLRRSLSAASCAPISLPAAASRSSMDGAGA
EEVLAPLRLAVRQQGDLVRKLKEDKAPQVDVDKAVAELKARKRVLEAKELALQPKDDIVD
RAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDC
TMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEME
SVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPET
AQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEK
DHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKV
GISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPL
VAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEF
TIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDE
QRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYAR
TDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVE
ARYPLFEGQETGKKETIEE

# Metabolic_Enzyme_8_Number_of_Residues:
739

# Metabolic_Enzyme_8_Molecular_Weight:
83140

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  glycine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  glycyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_8_Specific_Function:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_8_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_8_Reaction:
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 6.1.1.14

# Metabolic_Enzyme_8_GenBank_ID_Protein:
1311463

# Metabolic_Enzyme_8_SwissProt_ID:
SYG_HUMAN (P41250)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
GARS

# Metabolic_Enzyme_8_Geneatlas_id:
GARS

# Metabolic_Enzyme_8_hgnc_id:
HGNC:4162

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Not Available

# Metabolic_Enzyme_8_Gene_Sequence:
>2220 bp
ATGCCCTCTCCGCGTCCAGTGCTGCTTAGAGGTGCTCGCGCCGCTCTGCTGCTGCTGCTG
CCGCCCCGGCTCTTAGCCCGACCCTCGCTCCTGCTCCGCCGGTCCCTCAGCGCGGCCTCC
TGCGCCCCGATCTCCTTGCCCGCCGCCGCCTCCCGGAGCAGCATGGACGGCGCGGGGGCT
GAGGAGGTGCTGGCACCTCTGAGGCTAGCAGTGCGCCAGCAGGGAGATCTTGTGCGAAAA
CTCAAAGAAGATAAAGCACCCCAAGTAGACGTAGACAAAGCAGTGGCTGAGCTCAAAGCC
CGCAAGAGGGTTCTGGAAGCAAAGGAGCTGGCGTTACAGCCCAAAGATGATATTGTAGAC
CGAGCAAAAATGGAAGATACCCTGAAGAGGAGGTTTTTCTATGATCAAGCTTTTGCTATT
TATGGAGGTGTTAGTGGTCTGTATGACTTTGGGCCAGTTGGCTGTGCTTTGAAGAACAAT
ATTATTCAGACCTGGAGGCAGCACTTTATCCAAGAGGAACAGATCCTGGAGATCGATTGC
ACCATGCTCACCCCTGAGCCAGTTTTAAAGACCTCTGGCCATGTAGACAAATTTGCTGAC
TTCATGGTGAAAGACGTAAAAAATGGAGAATGTTTTCGTGCTGACCATCTATTAAAAGCT
CATTTACAGAAATTGATGTCTGATAAGAAGTGTTCTGTCGAAAAGAAATCAGAAATGGAA
AGTGTTTTGGCCCAGCTTGATAACTATGGACAGCAAGAACTTGCGGATCTTTTTGTGAAC
TATAATGTAAAATCTCCCATTACTGGAAATGATCTATCCCCTCCAGTGTCTTTTAACTTA
ATGTTCAAGACTTTCATTGGGCCTGGAGGAAACATGCCTGGGTACTTGAGACCAGAAACT
GCACAGGGGATTTTCTTGAATTTCAAACGACTTTTGGAGTTCAACCAAGGAAAGTTGCCT
TTTGCTGCTGCCCAGATTGGAAATTCTTTTAGAAATGAGATCTCCCCTCGATCTGGACTG
ATCAGAGTCAGAGAATTCACAATGGCAGAAATTGAGCACTTTGTAGATCCCAGTGAGAAA
GACCACCCCAAGTTCCAGAATGTGGCAGACCTTCACCTTTATTTGTATTCAGCAAAAGCC
CAGGTCAGCGGACAGTCCGCTCGGAAAATGCGCCTGGGAGATGCTGTTGAACAGGGTGTG
ATTAATAACACAGTATTAGGCTATTTCATTGGCCGCATCTACCTCTACCTCACGAAGGTT
GGAATATCTCCAGATAAACTCCGCTTCCGGCAGCACATGGAGAATGAGATGGCCCATTAT
GCCTGTGACTGTTGGGATGCAGAATCCAAAACATCCTACGGTTGGATTGAGATTGTTGGA
TGTGCTGATCGTTCCTGTTATGACCTCTCCTGTCATGCACGAGCCACCAAAGTCCCACTT
GTAGCTGAGAAACCTCTGAAAGAACCCAAAACAGTCAATGTTGTTCAGTTTGAACCCAGT
AAGGGAGCAATTGGTAAGGCATATAAGAAGGATGCAAAACTGGTGATGGAGTATCTTGCC
ATTTGTGATGAGTGCTACATTACAGAAATGGAGATGCTGCTGAATGAGAAAGGGGAATTC
ACAATTGAAACTGAAGGGAAAACATTTCAGTTAACAAAAGACATGATCAATGTGAAGAGA
TTCCAGAAAACACTATATGTGGAAGAAGTTGTTCCGAATGTAATTGAACCTTCCTTCGGC
CTGGGTAGGATCATGTATACGGTATTTGAACATACATTCCATGTACGAGAAGGAGATGAA
CAGAGAACATTCTTCAGTTTCCCTGCTGTAGTTGCTCCATTCAAATGTTCCGTCCTCCCA
CTGAGCCAAAACCAGGAGTTCATGCCATTTGTCAAGGAATTATCGGAAGCCCTGACCAGG
CATGGAGTATCTCACAAAGTAGACGATTCCTCTGGGTCAATCGGAAGGCGCTATGCCAGG
ACTGATGAGATTGGCGTGGCTTTTGGTGTCACCATTGACTTTGACACAGTGAACAAGACC
CCCCACACTGCAACTCTGAGGGACCGTGACTCAATGCGGCAGATAAGAGCAGAGATCTCT
GAGCTGCCCAGCATAGTCCAAGACCTAGCCAATGGCAACATCACATGGGCTGATGTGGAG
GCCAGGTATCCTCTGTTTGAAGGGCAAGAGACTGGTAAAAAAGAGACAATCGAGGAATGA


# Metabolic_Enzyme_8_GenBank_ID_Gene:
D30658

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_8_Locus:
7p15

# Metabolic_Enzyme_8_SNPs:
rs17159287; rs34886142; rs17159306; rs7808770; rs3886641; rs11553502; rs1049402; rs2970504; rs2529438; rs1468402; rs2709806; rs2527880; rs728539; rs12532057; rs2709778; rs2529439; rs11981106; rs2709809; rs2240401; rs11979352; rs6945035; rs722423; rs10951271; rs758000; rs10239660; rs2527878; rs2527879; rs10249885; rs6462214; rs1558064; rs10487699; rs2893390; rs10487700; rs3807632; rs10265589; rs1986756; rs13228758; rs6970807; rs17159291; rs10280491; rs2240400; rs2709772; rs16875290; rs10233132; rs13228097; rs17159273; rs17159275; rs6950015; rs11980069; rs2072236; rs17159267; rs10239537; rs11982890; rs6947982; rs17159289; rs2074779; rs11976576; rs17159279; rs17159296; rs11761080; rs2529441; rs17159280; rs2529442; rs2952804; rs6945223; rs17159272; rs2270025; rs2214837; rs11553498; rs1049399; rs11553503; rs17159262; rs35302357; rs3807633; rs35241091; rs3840589; rs34230821; rs11465024; rs35711502; rs34957085; rs34725384; rs13228094; rs2240501; rs41275991; rs34457367; rs6945546; rs10229836; rs35151755; rs34785207; rs2709771; rs34149226; rs10264469; rs6945475; rs1986757; rs3840588; rs6945586; rs41275988; rs36125163; rs35425165; rs34885661; rs13226718; rs35821025; rs2952805; rs35482863; rs34495080; rs11454228; rs13228006; rs34668775; rs2893388; rs35045679; rs2190241; rs2893389; rs4000210; rs10243040; rs10249882; rs11983525; rs12667790; rs13232935; rs16875282; rs16875285; rs1859644; rs2529437; rs38494; rs38497; rs38498; rs39739; rs4266550; rs4526262; rs6956054; rs7791663; rs7809256; rs7810227

# Metabolic_Enzyme_8_General_References:
7962006; 7753621; 7961834

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5838

# Metabolic_Enzyme_9_Name:
Ribose-phosphate pyrophosphokinase III

# Metabolic_Enzyme_9_Synonyms:
Phosphoribosyl pyrophosphate synthetase III; PRS-III; Phosphoribosyl pyrophosphate synthetase 1-like 1

# Metabolic_Enzyme_9_Gene_Name:
PRPS1L1

# Metabolic_Enzyme_9_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IIIMPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQ
SGCGEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLS
IAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKR
VTSIADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLL
SAGATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILA
EAIRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_9_Number_of_Residues:
318

# Metabolic_Enzyme_9_Molecular_Weight:
34840

# Metabolic_Enzyme_9_Theoretical_pI:
6.31

# Metabolic_Enzyme_9_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_9_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_9_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_9_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_9_GenBank_ID_Protein:
190522

# Metabolic_Enzyme_9_SwissProt_ID:
PRPS3_HUMAN (P21108)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
PRPS1L1

# Metabolic_Enzyme_9_Geneatlas_id:
PRPS1L1

# Metabolic_Enzyme_9_hgnc_id:
HGNC:9463

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>957 bp
ACGCCGAATATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCCCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAATTCAGCAACCAGGAGACC
TGCGTGGAAATTGATGAGAGTGTGCGTGGAGAGGATGTCTACATCGTTCAGAGTGGTTGT
GGCGAAATCAACGACAGTCTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCTAGCCGAGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGACAGGATAAGAAG
GATAAGAGCCGGTCCCCAATCTCTGCCAAGCTTGTTGCAAATATGCTCTCTATAGCAGGT
GCGGATCATATCATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAACTTGTATGCAGAGCCAACTGTCCTGAAGTGGATAAGGGAGAATATCCCT
GAGTGGAAGAACTGCATTATTGTCTCGCCAGATGCTGGTGGAGCTAAAAGAGTGACCTCC
ATTGCAGACCAGTTGAATGTGGACTTTGCTTTGATTCATAAAGAACGGAAGAAGGCCAAT
GAAGTGGACTGCATAGTGCTAGTGGGAGATGTGAATGATCGTGTGGCTATCCTTGTAGAT
GACATGGCAGACACTTGTGTTACAATCTGCCTCGCAGCTGACAAACTTCTCTCAGCTGGA
GCAACCAGAGTTTATGCTATCTTGACTCATGGAATCTTTTCTGGCCCAGCCATTTCTCGC
ATCAACACTGCATGCTTTGAAGCAGTGGTAGTCACCAATACCATACCTCAAGATGAGAAG
ATGAAGCATTGCTCCAAAATACGAGTAATTGACATCTCCATGATCCTTGCAGAAGCCATA
AGGAGAACTCATAATGGGGAATCTGTTTCCTACCTGTTCAGCCATGTTCCTTTATAA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M57423

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_9_Locus:
7p21.1

# Metabolic_Enzyme_9_SNPs:
rs3800962; rs3800961; rs7780180; rs7803591; rs12668788; rs12699957; rs12666668; rs12672880; rs12673527; rs6461371; rs13231261; rs1126434; rs1126437; rs13231476; rs35708479; rs35797266; rs6946658; rs6978339; rs35289138; rs6946544; rs7800497; rs7784246; rs10950697; rs13226748; rs4236293; rs4555993; rs4555994; rs4618585; rs6953082; rs6962130; rs6962299; rs6963707; rs6974404; rs6975848; rs6976627; rs6976951; rs7781217; rs7781290; rs7800421

# Metabolic_Enzyme_9_General_References:
2168892

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5839

# Metabolic_Enzyme_10_Name:
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase

# Metabolic_Enzyme_10_Synonyms:
Glutamate--tRNA ligase; Prolyl-tRNA synthetase; Proline--tRNA ligase]

# Metabolic_Enzyme_10_Gene_Name:
EPRS

# Metabolic_Enzyme_10_Protein_Sequence:
>Bifunctional aminoacyltRNA synthetase Includes: GlutamyltRNA synthetase
MEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATLKGNA
AWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEKKQDVGKFVELPG
AEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVI
LEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIESKHR
KNPIEKNLQMWEEMKKGSQFGHSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYN
VYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTV
LSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKI
WAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFI
EGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKFNLENKDYKKTTKVTWLAE
TTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQL
QRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTKVEATKNETSAPF
KERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAAVKQLLSLKAEYK
EKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKLKAEKSPKAKINE
AVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPEAKVLFDKVASQG
EVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAEDKDKKKKEKENKS
EKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKKEENLADWYSQVI
TKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKT
HVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVR
WEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTE
KEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNS
WGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRR
RLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTV
AENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEID
CEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKNPAKYYTLFGRSY


# Metabolic_Enzyme_10_Number_of_Residues:
1440

# Metabolic_Enzyme_10_Molecular_Weight:
163028

# Metabolic_Enzyme_10_Theoretical_pI:
7.75

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  proline-tRNA ligase activity
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  prolyl-tRNA aminoacylation
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_10_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_10_Specific_Function:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00860  Porphyrin and chlorophyll metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_10_Reaction:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF09180:ProRS-C_1;
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 6.1.1.17;EC 6.1.1.15

# Metabolic_Enzyme_10_GenBank_ID_Protein:
31958

# Metabolic_Enzyme_10_SwissProt_ID:
SYEP_HUMAN (P07814)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
EPRS

# Metabolic_Enzyme_10_Geneatlas_id:
EPRS

# Metabolic_Enzyme_10_hgnc_id:
HGNC:3418

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>4323 bp
ATGGAACATACTGAGATTGATCACTGGTTGGAGTTCAGTGCTACAAAATTATCTTCATGT
GATTCCTTTACTTCTACAATTAATGAACTCAATCATTGCCTGTCTCTGAGAACATACTTA
GTTGGAAACTCCTTGAGTTTAGCAGATTTATGTGTTTGGGCCACCCTAAAAGGAAATGCT
GCCTGGCAAGAACAGTTGAAACAGAAGAAAGCTCCAGTTCATGTAAAACGTTGGTTTGGC
TTTCTTGAAGCCCAGCAGGCCTTCCAGTCAGTAGGTACCAAGTGGGATGTTTCAACAACC
AAAGCTCGAGTGGCACCTGAGAAAAAGCAAGATGTTGGGAAATTTGTTGAGCTTCCAGGT
GCGGAGATGGGAAAGGTTACCGTCAGATTTCCTCCAGAGGCCAGTGGTTACTTACACATT
GGGCATGCAAAAGCTGCTCTTCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTG
ATCATGAGATTTGATGACACAAATCCTGAAAAAGAAAAGGAAGATTTTGAGAAGGTTATC
TTGGAAGATGTTGCAATGTTGCATATCAAACCAGATCAATTTACTTATACTTCGGATCAT
TTTGAAACTATAATGAAGTATGCAGAGAAGCTAATTCAAGAAGGGAAGGCTTATGTGGAT
GATACTCCTGCTGAACAGATGAAAGCAGAACGTGAGCAGAGGATAGAATCTAAACATAGA
AAAAACCCTATTGAGAAGAATCTACAAATGTGGGAAGAAATGAAAAAAGGGAGCCAGTTT
GGTCACTCCTGTTGTTTGCGAGCAAAAATTGACATGAGTAGTAACAATGGATGCATGAGA
GATCCAACCCTTTATCGCTGCAAAATTCAACCACATCCAAGAACTGGAAATAAATACAAT
GTTTATCCAACATATGATTTTGCCTGCCCCATAGTTGACAGCATCGAAGGTGTTACACAT
GCCCTGAGAACAACAGAATACCATGACAGAGATGAGCAGTTTTACTGGATTATTGAAGCT
TTAGGCATAAGAAAACCATATATTTGGGAATATAGTCGGCTAAATCTCAACAACACAGTG
CTATCCAAAAGAAAACTCACATGGTTTGTCAATGAAGGACTAGTAGATGGATGGGATGAC
CCAAGATTTCCTACGGTTCGTGGTGTACTGAGAAGAGGGATGACAGTTGAAGGACTGAAA
CAGTTTATTGCTGCTCAGGGCTCCTCACGTTCAGTCGTGAACATGGAGTGGGACAAAATC
TGGGCGTTTAACAAAAAGGTTATTGACCCAGTGGCTCCACGATATGTTGCATTACTGAAG
AAAGAAGTGATCCCAGTGAATGTACCTGAAGCTCAGGAGGAGATGAAAGAAGTAGCCAAA
CACCCAAAGAATCCTGAGGTTGGCTTGAAGCCTGTGTGGTATAGTCCCAAAGTTTTCATT
GAAGGTGCTGATGCAGAGACTTTTTCGGAGGGTGAGATGGTTACATTTATAAATTGGGGC
AACCTCAACATTACAAAAATACACAAAAATGCAGATGGAAAAATCATATCTCTTGATGCA
AAGTTTAATTTGGAAAACAAAGACTACAAGAAAACCACTAAGGTCACTTGGCTTGCAGAG
ACTACACATGCTCTTCCTATTCCAGTAATCTGTGTCACTTATGAGCACTTGATCACAAAG
CCAGTGCTAGGAAAAGACGAGGACTTTAAGCAGTATGTCAACAAGAACAGTAAGCATGAA
GAGCTAATGCTAGGGGATCCCTGCCTTAAGGATTTGAAAAAAGGAGATATTATACAACTC
CAGAGAAGAGGATTCTTCATATGTGATCAACCTTATGAACCTGTTAGCCCATATAGTTGC
AAGGAAGCCCCGTGTGTTTTGATATACATTCCTGATGGGCACACAAAGGAAATGCCAACA
TCAGGGTCAAAGGAAAAGACCAAAGTAGAAGCCACAAAAAATGAGACCTCTGCTCCTTTT
AAGGAAAGACCAACACCTTCTCTGAATAATAATTGTACTACATCTGAGGATTCCTTGGTC
CTTTACAATAGAGTGGCTGTTCAAGGAGATGTGGTTCGTGAATTAAAAGCCAAGAAAGCA
CCAAAGGAAGATGTAGATGCAGCTGTAAAACAGCTTTTGTCTTTGAAAGCTGAATATAAG
GAGAAAACTGGCCAGGAATATAAACCTGGAAACCCTCCTGCTGAAATAGGACAGAATATT
TCTTCTAATTCCTCAGCAAGTATTCTGGAAAGTAAATCTCTGTATGATGAAGTTGCTGCA
CAAGGGGAGGTGGTTCGTAAGCTAAAAGCTGAAAAATCCCCTAAGGCTAAAATAAATGAA
GCTGTAGAATGCTTACTGTCCCTGAAGGCTCAGTATAAAGAAAAAACTGGGAAGGAGTAC
ATACCTGGTCAGCCCCCATTATCTCAAAGTTCGGATTCAAGCCCAACCAGAAATTCTGAA
CCTGCTGGTTTAGAAACACCAGAAGCGAAAGTACTTTTTGACAAAGTAGCTTCTCAAGGG
GAAGTAGTTCGGAAACTTAAAACTGAAAAAGCCCCTAAGGATCAAGTAGATATAGCTGTT
CAAGAACTCCTTCAGCTAAAGGCACAGTACAAGTCTTTGATAGGAGTAGAGTATAAGCCT
GTGTCGGCCACTGGAGCTGAGGACAAAGATAAGAAGAAGAAAGAAAAAGAAAATAAATCT
GAAAAGCAGAATAAGCCTCAGAAACAAAATGATGGCCAAAGGAAAGACCCTTCTAAAAAC
CAAGGAGGTGGGCTCTCATCAAGTGGAGCAGGAGAAGGGCAGGGGCCTAAGAAACAGACC
AGGTTGGGTCTTGAGGCAAAAAAAGAAGAAAATCTTGCTGATTGGTATTCTCAGGTCATC
ACAAAGTCAGAAATGATTGAATACCATGACATAAGTGGCTGTTATATTCTTCGTCCCTGG
GCCTATGCCATTTGGGAAGCCATCAAGGACTTTTTTGATGCTGAGATCAAGAAACTTGGT
GTTGAAAACTGCTACTTCCCCATGTTTGTGTCTCAAAGTGCATTAGAGAAAGAGAAGACT
CATGTTGCTGACTTTGCCCCAGAGGTTGCTTGGGTTACAAGATCTGGCAAAACCGAGCTG
GCAGAACCAATTGCCATTCGTCCTACTAGTGAAACAGTAATGTATCCTGCATATGCAAAA
TGGGTACAATCACACAGAGACCTGCCCATCAAGCTCAATCAGTGGTGCAATGTGGTGCGT
TGGGAATTCAAGCATCCTCAGCCTTTCCTACGTACTCGTGAATTTCTTTGGCAGGAAGGG
CACAGTGCTTTTGCTACCATGGAAGAGGCAGCGGAAGAGGTCTTGCAGATACTTGACTTA
TATGCTCAGGTATATGAAGAACTCCTGGCAATTCCTGTTGTTAAAGGAAGAAAGACGGAA
AAGGAAAAATTTGCAGGAGGAGACTATACAACTACAATAGAAGCATTTATATCTGCTAGT
GGAAGAGCTATCCAGGGAGGAACATCACATCATTTAGGGCAGAATTTTTCCAAAATGTTT
GAAATCGTTTTTGAAGATCCAAAGATACCAGGAGAGAAGCAATTTGCCTATCAAAACTCC
TGGGGCCTGACAACTCGAACTATTGGTGTTATGACCATGGTTCATGGGGACAACATGGGT
TTAGTATTACCACCCCGTGTAGCATGTGTTCAGGTGGTGATTATTCCTTGTGGCATTACC
AATGCACTTTCTGAAGAAGACAAAGAAGCGCTGATTGCAAAATGCAATGATTATCGAAGG
CGATTACTCAGTGTTAACATCCGCGTTAGAGCTGATTTACGAGATAATTATTCTCCAGGT
TGGAAATTCAATCACTGGGAGCTCAAGGGAGTTCCCATTAGACTTGAAGTTGGGCCACGT
GATATGAAGAGCTGTCAGTTTGTAGCCGTCAGACGAGATACTGGAGAAAAGCTGACAGTT
GCTGAAAATGAGGCAGAGACTAAACTTCAAGCTATTTTGGAAGACATCCAGGTCACCCTT
TTCACAAGGGCTTCTGAAGACCTTAAGACTCATATGGTTGTGGCTAATACAATGGAAGAC
TTTCAGAAGATACTAGATTCTGGAAAGATTGTTCAGATTCCATTCTGTGGGGAAATTGAC
TGTGAGGACTGGATCAAAAAGACCACTGCCAGGGATCAAGATCTTGAACCTGGTGCTCCA
TCCATGGGAGCTAAAAGCCTTTGCATCCCCTTCAAACCACTCTGTGAACTGCAGCCTGGA
GCCAAATGTGTCTGTGGCAAGAACCCTGCCAAGTACTACACCTTATTTGGTCGCAGCTAC
TGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
X54326

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1q41-q42

# Metabolic_Enzyme_10_SNPs:
rs5030752; rs2230301; rs35999099; rs34559775; rs5030751; rs1061160; rs5030754; rs36122746; rs1061242; rs1061248; rs6695781; rs2577138; rs1768672; rs2647468; rs1694601; rs2647447; rs2577144; rs2647459; rs2133194; rs2577150; rs1498393; rs2789797; rs2795314; rs2291838; rs2647435; rs2173403; rs2577145; rs1694576; rs2647462; rs2133195; rs2647469; rs1768673; rs2577137; rs1624678; rs2270710; rs2795310; rs2789816; rs2577136; rs2577159; rs7535767; rs1391566; rs10779396; rs7550249; rs1611961; rs7553236; rs2577149; rs2647430; rs6541124; rs10495143; rs3820457; rs3767671; rs6697041; rs6686451; rs1630386; rs2270711; rs10746395; rs1982985; rs7535773; rs12080607; rs6699641; rs6669906; rs1982986; rs2647470; rs2248479; rs2577148; rs2789798; rs4846612; rs2577146; rs2270712; rs1694577; rs2577140; rs2647445; rs2647461; rs2789793; rs10779393; rs6541120; rs1874811; rs2789794; rs2647464; rs7535650; rs2647463; rs6690630; rs3816993; rs2254494; rs2647457; rs2789817; rs2647454; rs2789796; rs11806631; rs2647420; rs2647428; rs2253521; rs2647458; rs2577141; rs1658227; rs2248466; rs2577158; rs6681471; rs2647436; rs2577156; rs2270709; rs7536968; rs2577163; rs10779395; rs11118485; rs3767661; rs4846611; rs2647479; rs11118490; rs7521682; rs6660598; rs2291836; rs2647429; rs3767670; rs1694599; rs2789809; rs6681055; rs1658226; rs2789813; rs12057663; rs10779394; rs10442684; rs12079635; rs2789810; rs11118488; rs10746396; rs2647453; rs10779391; rs7548397; rs2647467; rs3767669; rs2577142; rs10863524; rs10863528; rs11118486; rs10863523; rs7524619; rs7527659; rs1768665; rs10863521; rs7517173; rs4531301; rs2454326; rs12084571; rs3767675; rs1982987; rs7521388; rs2647478; rs7539385; rs6672134; rs17007062; rs10863527; rs4846610; rs6683340; rs7537559; rs7527749; rs12126940; rs12142009; rs2577147; rs2789799; rs4536003; rs949866; rs2789812; rs12022181; rs2789802; rs6703042; rs1768675; rs2647446; rs10863525; rs17007011; rs2248717; rs1612144; rs12032898; rs1557130; rs1846254; rs12032866; rs10442692; rs17006978; rs12123041; rs10863522; rs2647444; rs2647460; rs1694600; rs1768677; rs3767668; rs7537058; rs11118487; rs11118480; rs1768668; rs1622508; rs12073836; rs3767657; rs6674466; rs2647425; rs1566252; rs3820456; rs1768671; rs2789811; rs11118489; rs1768670; rs2647433; rs1768666; rs1498394; rs1874813; rs2486328; rs1874810; rs2577151; rs4379680; rs12069364; rs12726890; rs2248719; rs2577143; rs10863526; rs6692978; rs1982984; rs2245457; rs6681474; rs1694575; rs12048112; rs2577160; rs2789795; rs12140664; rs7545314; rs11811749; rs7531703; rs2577139; rs2647431; rs2789815; rs2647432; rs11118483; rs6690280; rs1874812; rs2577165; rs3767663; rs1768669; rs1874814; rs9988498; rs12117454; rs1846255; rs3767658; rs2647438; rs17007084; rs2647474; rs1768676; rs2647448; rs7534891; rs17006931; rs2577161; rs3816994; rs2027504; rs2030078; rs2030079; rs11118477; rs5030753; rs1063236; rs35325299; rs35055527; rs12144752; rs35578666; rs10987; rs41274786; rs2270713; rs2789804; rs5781162; rs12097519; rs11322745; rs28758924; rs10543617; rs35970586; rs2647424; rs35064558; rs35228542; rs34101093; rs12737399; rs35193743; rs12128043; rs12141517; rs3215088; rs1768667; rs35845125; rs12080935; rs35917562; rs2577164; rs5781163; rs12068478; rs7545874; rs6669531; rs35942761; rs36078678; rs1768674; rs12126592; rs12754826; rs6677609; rs2647423; rs35420771; rs12098052; rs34415535; rs2291837; rs10582505; rs2647434; rs2577157; rs12057468; rs10551734; rs2789806; rs12091960; rs35440326; rs33962064; rs34070653; rs2789800; rs3835619; rs34052861; rs35525846; rs34510927; rs35952109; rs3830400; rs1614719; rs10698600; rs7544184; rs35962858; rs953756; rs12031429; rs6670629; rs12080610; rs28609698; rs3830399; rs33914465; rs2647449; rs34314894; rs12090303; rs10570178; rs36181278; rs35341641; rs12736674; rs7414048; rs2647450; rs10569658; rs2789819; rs35995726; rs35247222; rs7548301; rs12084196; rs12059479; rs34224725; rs35329556; rs2647437; rs3767673; rs2647475; rs35539406; rs11414713; rs11340220; rs11323724; rs10547980; rs11118482; rs3767667; rs12060231; rs35015102; rs35656997; rs2647452; rs12145391; rs35659781; rs11808639; rs12097441; rs12141971; rs10157133; rs7525311; rs10612871; rs12071984; rs35469644; rs34084629; rs2789808; rs34084372; rs12238988; rs12059527; rs12754990; rs2647427; rs34218503; rs9786983; rs10645019; rs12747650; rs2789807; rs11284910; rs35194885; rs34320023; rs12062082; rs11325774; rs10697205; rs10638364; rs2789805; rs10697206; rs35018508; rs10465680; rs35938749; rs10554810; rs5781161; rs12090804; rs11118478; rs6680671; rs34316201; rs35787330; rs2795315; rs41304103; rs10656420; rs34626963; rs1614384; rs12071410; rs12059273; rs11291617; rs35145633; rs2647451; rs2647456; rs34170326; rs12040930; rs2647422; rs36089275; rs34459588; rs35449773; rs35391458; rs12045445; rs7539406; rs1542840; rs34090474; rs1614585; rs41274788; rs2011624; rs12095669; rs34544630; rs6702241; rs2647421; rs28612895; rs7524382; rs10442691; rs12081205; rs34917248; rs2133196; rs10551735; rs34309222; rs35204038; rs3835618; rs6667964; rs35446521; rs35241194; rs41304101; rs17007032; rs11278281; rs2647426; rs10595099; rs11382775; rs12049352; rs35440314; rs10570179; rs12058150; rs3055587; rs34026037; rs34537346; rs34343274; rs12076227; rs12046562; rs34094913; rs3835617; rs34000580; rs34321649; rs35060859; rs35108914; rs2647455; rs1909199; rs3916109; rs36065087; rs28570471; rs12072662; rs11286771; rs11118481; rs2789803; rs2577162; rs11317813; rs5781164; rs35421250; rs10157645; rs5781160; rs35984976; rs11355174; rs35879695; rs35533895; rs10611128; rs11590370; rs10779390; rs11118476; rs12734813; rs2789784; rs4846608; rs6663868; rs6663947; rs7516830; rs7549576

# Metabolic_Enzyme_10_General_References:
1988429; 3290852; 1756734; 1556743; 11123902

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5840

# Metabolic_Enzyme_11_Name:
Ubiquitin-conjugating enzyme E2-25 kDa

# Metabolic_Enzyme_11_Synonyms:
Ubiquitin- protein ligase; Ubiquitin carrier protein; E2(25K; Huntingtin- interacting protein 2; HIP-2

# Metabolic_Enzyme_11_Gene_Name:
HIP2

# Metabolic_Enzyme_11_Protein_Sequence:
>Ubiquitinconjugating enzyme E225 kDa
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI
KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA
EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI
VALSSKSWDVETATELLLSN

# Metabolic_Enzyme_11_Number_of_Residues:
200

# Metabolic_Enzyme_11_Molecular_Weight:
22407

# Metabolic_Enzyme_11_Theoretical_pI:
5.10

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Not Available

# Metabolic_Enzyme_11_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53

# Metabolic_Enzyme_11_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_11_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00627:UBA;
PF00179:UQ_con

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_11_GenBank_ID_Protein:
1381164

# Metabolic_Enzyme_11_SwissProt_ID:
UBC1_HUMAN (P61086)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
HIP2

# Metabolic_Enzyme_11_Geneatlas_id:
HIP2

# Metabolic_Enzyme_11_hgnc_id:
HGNC:4914

# Metabolic_Enzyme_11_PDB_ID:
1YLA

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>603 bp
ATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAG
GAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGA
GGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATA
AAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGG
CATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGG
GCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCA
GAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGTACAAACAAAATCCCGAAATG
TTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCA
GAATACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCAGTAATA
GTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAAC
TGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
U58522

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_11_Locus:
4p14

# Metabolic_Enzyme_11_SNPs:
rs438344; rs725856; rs463918; rs417393; rs459274; rs2054718; rs302948; rs7687557; rs467032; rs302931; rs4975036; rs877075; rs7697939; rs305121; rs305826; rs215399; rs6830937; rs302946; rs302949; rs2381428; rs305825; rs725857; rs302935; rs456157; rs305827; rs302938; rs305125; rs10440307; rs302952; rs12645606; rs6828986; rs383020; rs13129403; rs302937; rs3806739; rs12644528; rs6531738; rs6810434; rs7684747; rs652162; rs11945490; rs305124; rs11939222; rs9996105; rs12648825; rs431419; rs7663847; rs10517528; rs1384531; rs12641379; rs159987; rs10856850; rs11933569; rs7678527; rs11942087; rs9683743; rs302932; rs12647535; rs188566; rs418876; rs4512005; rs2279850; rs7693996; rs465233; rs12646744; rs10004937; rs13121644; rs12506764; rs10015357; rs35401248; rs12642132; rs13108390; rs302941; rs302947; rs167360; rs1055582; rs17510894; rs7665965; rs4974947; rs411556; rs13147205; rs12507502; rs7690684; rs17585617; rs4403062; rs7441133; rs6531741; rs13435632; rs7656037; rs7683797; rs724256; rs4974948; rs461962; rs11947610; rs302950; rs602049; rs9306975; rs10029519; rs13150753; rs10022877; rs440105; rs7697286; rs7656723; rs7661070; rs4362831; rs12505675; rs302936; rs6814847; rs12645756; rs614180; rs10005267; rs13122400; rs4377601; rs7441135; rs12649966; rs12648483; rs302945; rs2170613; rs13139884; rs305123; rs10014622; rs12648906; rs6818053; rs302940; rs4314294; rs6848230; rs12513088; rs3912392; rs7658679; rs3912391; rs9996828; rs17439268; rs34945144; rs3839130; rs1064268; rs458618; rs34388979; rs34643475; rs10022177; rs28664181; rs35905641; rs2381427; rs415625; rs11406192; rs35852990; rs12641284; rs34711359; rs28650183; rs11315878; rs191002; rs34394500; rs28394846; rs17439205; rs7695000; rs35605027; rs36032554; rs10007588; rs10683010; rs35095660; rs34373308; rs13103577; rs28567992; rs35461119; rs13140152; rs34508184; rs28752210; rs6848232; rs6531740; rs28727931; rs10032541; rs28379845; rs28475675; rs34603997; rs34513146; rs28475266; rs305122; rs10033569; rs34406402; rs13123105; rs10659004; rs28651273; rs28626946; rs11393049; rs9799379; rs28495663; rs35360114; rs12643005; rs28519425; rs11727635; rs35230099; rs28379059; rs3839129; rs446539; rs35941407; rs36211815; rs28459348; rs11407762; rs28670201; rs16995470; rs28666528; rs12647701; rs7437985; rs462069; rs188565; rs463322; rs28668414; rs388277; rs28469340; rs4543121; rs4975037; rs34121884; rs28449607; rs302934; rs13137353; rs35785999; rs35484323; rs28610924; rs33949384; rs35850563; rs35596173; rs7377134; rs10650873; rs403338; rs13103375; rs35490777; rs9993641; rs160096; rs28702416; rs11726696; rs9998102; rs34796394; rs35768449; rs10027513; rs10006221; rs36004717; rs457198; rs13113031; rs7654219; rs35064302; rs36215155; rs35488035; rs34812049; rs458114; rs3070777; rs11947966; rs401797; rs10674974; rs13113029; rs34238835; rs34434032; rs10007152; rs10716637; rs36232683; rs401196; rs35121528; rs34700981; rs11452198; rs35251652; rs28637149; rs28645678; rs35599030; rs404985; rs33946386; rs12643916; rs28567929; rs28612080; rs7437980; rs12646741; rs35355790; rs34112267; rs34201270; rs11295454; rs33925862; rs7679042; rs28465426; rs465113; rs35733561; rs442644; rs11323808; rs6825216; rs35957337; rs10440308; rs167328; rs33911981; rs28588288; rs28602495; rs11389468; rs33973834; rs302933; rs35468992; rs10538309; rs10001359; rs28582996; rs41282377; rs36046193; rs462108; rs35470056; rs9995971; rs28695490; rs11276965; rs28366560; rs34608829; rs35696651; rs3841980; rs28628754; rs160088; rs7657535; rs33995934; rs7440233; rs34679528; rs35547843; rs7688345; rs36214079; rs33977990; rs28438631; rs36098911; rs6531739; rs35004843; rs33914257; rs35647476; rs28749267; rs2381431; rs455159; rs466169; rs28629917; rs34218534; rs34727929; rs28370449; rs461918; rs11364737; rs34509777; rs34820330; rs159986; rs3932978; rs13134745; rs13123425; rs11936326; rs35173955; rs28435721; rs10009932; rs35183095; rs35646853; rs34417192; rs167327; rs28620307; rs28719817; rs11407158; rs28742000; rs35367181; rs2381429; rs10015234; rs413452; rs5857700; rs10639345; rs34133576; rs35972302; rs149477; rs33916064; rs7694944; rs35127944; rs4502689; rs28600929; rs28407484; rs6857873; rs34258469; rs35532814; rs35022888; rs35287077; rs419332; rs7668685; rs191001; rs28526586; rs10541441; rs28529766; rs13118375; rs34597587; rs10017303; rs35240266; rs35637004; rs11931904; rs7685348; rs12641923; rs33928368; rs463979; rs34859728; rs34462851; rs35210500; rs12643006; rs10699520; rs33918227; rs2627640; rs35005914; rs3069986; rs13142225; rs28575253; rs28361492; rs34401637; rs33959570; rs172552; rs9884353; rs35691398; rs34937270; rs5857698; rs28665570; rs614244; rs28849716; rs10012529; rs35370194; rs10540741; rs7674430; rs7685711; rs36120820; rs34132162; rs36213849; rs28680293; rs11417002; rs35215180; rs33944466; rs2381430; rs302951; rs650776; rs4975038; rs12510135; rs35586404; rs34069872; rs34032249; rs28469239; rs7685905; rs28730991; rs462088; rs458130; rs35635575; rs35078805; rs28479189; rs585756; rs28587078; rs28407810; rs34362070; rs4974946; rs13117685; rs6531737; rs35286645; rs4008351; rs7657126; rs302943; rs9999915; rs302942; rs1057047; rs35805800; rs35966248; rs28450192; rs7657502; rs35005579; rs1057048; rs4008350; rs10050182; rs10517530; rs1531897; rs192779; rs2128106; rs305135; rs305136; rs4263408; rs4388095; rs7670291; rs7680474; rs7681867

# Metabolic_Enzyme_11_General_References:
8702625; 10634809; 10675012; 12665801

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5351

# Metabolic_Enzyme_12_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

# Metabolic_Enzyme_12_Synonyms:
E- NPP 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1[Includes: Alkaline phosphodiesterase I; NPPase]

# Metabolic_Enzyme_12_Gene_Name:
ENPP1

# Metabolic_Enzyme_12_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPL
EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNC
RCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINY
SSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKK
CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEW
YKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLP
KDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL
ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSC
REPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNV
FSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVY
TPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYG
RPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPL
SPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTL
LRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD
TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSF
YQQRKEPVSDILKLKTHLPTFSQED

# Metabolic_Enzyme_12_Number_of_Residues:
925

# Metabolic_Enzyme_12_Molecular_Weight:
104925

# Metabolic_Enzyme_12_Theoretical_pI:
7.14

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity

# Metabolic_Enzyme_12_Pathway:
map00230  Purine metabolism;
 map00500  Starch and sucrose metabolism;
 map00740  Riboflavin metabolism;
 map00760  Nicotinate and nicotinamide metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_12_Reaction:
A dinucleotide + H2O = 2 mononucleotides

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_12_Signals:
None

# Metabolic_Enzyme_12_Transmembrane_Regions:
77-97

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.1.4.1;EC 3.6.1.9

# Metabolic_Enzyme_12_GenBank_ID_Protein:
189650

# Metabolic_Enzyme_12_SwissProt_ID:
ENPP1_HUMAN (P22413)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
ENPP1

# Metabolic_Enzyme_12_Geneatlas_id:
ENPP1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:3356

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Membrane; single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side

# Metabolic_Enzyme_12_Gene_Sequence:
>2622 bp
ATGGACGTGGGGGAGGAGCCGCTGGAGAAGGCGGCGCGCGCCCGCACTGCCAAGGACCCC
AACACCTATAAAGTACTCTCGCTGGTATTGTCAGTATGTGTGTTAACAACAATACTTGGT
TGTATATTTGGGTTGAAACCAAGCTGTGCCAAAGAAGTTAAAAGTTGCAAAGGTCGCTGT
TTCGAGAGAACATTTGGGAACTGTCGCTGTGATGCTGCCTGTGTTGAGCTTGGAAACTGC
TGTTTAGATTACCAGGAGACGTGCATAGAACCAGAACATATATGGACTTGCAACAAATTC
AGGTGTGGTGAGAAAAGGTTGACCAGAAGCCTCTGTGCCTGTTCAGATGACTGCAAGGAC
AAGGGCGACTGCTGCATCAACTACAGTTCTGTGTGTCAAGGTGAGAAAAGTTGGGTAGAA
GAACCATGTGAGAGCATTAATGAGCCACAGTGCCCAGCAGGGTTTGAAACGCCTCCTACC
CTCTTATTTTCTTTGGATGGATTCAGGGCAGAATATTTACACACTTGGGGTGGACTTCTT
CCTGTTATTAGCAAACTAAAAAAATGTGGAACATATACTAAAAACATGAGACCGGTATAT
CCAACAAAAACTTTCCCCAATCACTACAGCATTGTCACCGGATTGTATCCAGAATCTCAT
GGCATAATCGACAATAAAATGTATGATCCCAAAATGAATGCTTCCTTTTCACTTAAAAGT
AAAGAGAAATTTAATCCTGAGTGGTACAAAGGAGAACCAATTTGGGTCACAGCTAAGTAT
CAAGGCCTCAAGTCTGGCACATTTTTCTGGCCAGGATCAGATGTGGAAATTAACGGAATT
TTCCCAGACATCTATAAAATGTATAATGGTTCAGTACCATTTGAAGAAAGGATTTTAGCT
GTTCTTCAGTGGCTACAGCTTCCTAAAGATGAAAGACCACACTTTTACACTCTGTATTTA
GAAGAACCAGATTCTTCAGGTCATTCATATGGACCAGTCAGCAGTGAAGTCATCAAAGCC
TTGCAGAGGGTTGATGGTATGGTTGGTATGCTGATGGATGGTCTGAAAGAGCTGAACTTG
CACAGATGCCTGAACCTCATCCTTATTTCAGATCATGGCATGGAACAAGGCAGTTGTAAG
AAATACATATATCTGAATAAATATTTGGGGGATGTTAAAAATATTAAAGTTATCTATGGA
CCTGCAGCTCGATTGAGACCCTCTGATGTCCCAGATAAATACTATTCATTTAACTATGAA
GGCATTGCCCGAAATCTTTCTTGCCGGGAACCAAACCAGCACTTCAAACCTTACCTGAAA
CATTTCTTACCTAAGCGTTTGCACTTTGCTAAGAGTGATAGAATTGAGCCCTTGACATTC
TATTTGGACCCTCAGTGGCAACTTGCATTGAATCCCTCAGAAAGGAAATATTGTGGAAGT
GGATTTCATGGCTCTGACAATGTATTTTCAAATATGCAAGCCCTCTTTGTTGGCTATGGA
CCTGGATTCAAGCATGGCATTGAGGCTGACACCTTTGAAAACATTGAAGTCTATAACTTA
ATGTGTGATTTACTGAATTTGACACCGGCTCCTAATAACGGAACTCATGGAAGTCTTAAC
CACCTTCTAAAGAATCCTGTTTATACGCCAAAGCATCCCAAAGAAGTGCACCCCCTGGTA
CAGTGCCCCTTCACAAGAAACCCCAGAGATAACCTTGGCTGCTCATGTAACCCTTCGATT
TTGCCGATTGAGGATTTTCAAACACAGTTCAATCTGACTGTGGCAGAAGAGAAGATTATT
AAGCATGAAACTTTACCCTATGGAAGACCTAGAGTTCTCCAGAAGGAAAACACCATCTGT
CTTCTTTCCCAGCACCAGTTTATGAGTGGATACAGCCAAGACATCTTAATGCCCCTTTGG
ACATCCTATACCGTGGACAGAAATGACAGTTTCTCTACGGAAGACTTCTCCAACTGTCTG
TACCAGGACTTTAGAATTCCTCTTAGTCCTGTCCATAAATGTTCATTTTATAAAAATAAC
ACCAAAGTGAGTTACGGGTTCCTCTCCCCACCACAACTAAATAAAAATTCAAGTGGAATA
TATTCTGAAGCTTTGCTTACTACAAATATAGTGCCAATGTACCAGAGTTTTCAAGTTATA
TGGCGCTACTTTCATGACACCCTACTGCGAAAGTATGCTGAAGAAAGAAATGGTGTCAAT
GTCGTCAGTGGTCCTGTGTTTGACTTTGATTATGATGGACGTTGTGATTCCTTAGAGAAT
CTGAGGCAAAAAAGAAGAGTCATCCGTAACCAAGAAATTTTGATTCCAACTCACTTCTTT
ATTGTGCTAACAAGCTGTAAAGATACATCTCAGACGCCTTTGCACTGTGAAAACCTAGAC
ACCTTAGCTTTCATTTTGCCTCACAGGACTGATAACAGCGAGAGCTGTGTGCATGGGAAG
CATGACTCCTCATGGGTTGAAGAATTGTTAATGTTACACAGAGCACGGATCACAGATGTT
GAGCACATCACTGGACTCAGCTTCTATCAACAAAGAAAAGAGCCAGTTTCAGACATTTTA
AAGTTGAAAACACATTTGCCAACCTTTAGCCAAGAAGACTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M57736

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_12_Locus:
6q22-q23

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
2211644; 1315502; 14574404; 10480624; 8001561; 7737162; 9344668; 10453738

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5229

# Metabolic_Enzyme_13_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_13_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_13_Gene_Name:
NT5E

# Metabolic_Enzyme_13_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_13_Number_of_Residues:
574

# Metabolic_Enzyme_13_Molecular_Weight:
63368

# Metabolic_Enzyme_13_Theoretical_pI:
7.04

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_13_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_13_Signals:
1-26

# Metabolic_Enzyme_13_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_13_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_13_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
NT5E

# Metabolic_Enzyme_13_Geneatlas_id:
NT5E

# Metabolic_Enzyme_13_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_13_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_13_Locus:
6q14-q21

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5841

# Metabolic_Enzyme_14_Name:
Adenylate kinase isoenzyme 2, mitochondrial

# Metabolic_Enzyme_14_Synonyms:
ATP-AMP transphosphorylase

# Metabolic_Enzyme_14_Gene_Name:
AK2

# Metabolic_Enzyme_14_Protein_Sequence:
>Adenylate kinase isoenzyme 2, mitochondrial
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL
GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE
KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE
KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI

# Metabolic_Enzyme_14_Number_of_Residues:
239

# Metabolic_Enzyme_14_Molecular_Weight:
26478

# Metabolic_Enzyme_14_Theoretical_pI:
7.97

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
This small ubiquitous enzyme is essential for maintenance and cell growth

# Metabolic_Enzyme_14_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_14_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_14_GenBank_ID_Protein:
1209687

# Metabolic_Enzyme_14_SwissProt_ID:
KAD2_HUMAN (P54819)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
AK2

# Metabolic_Enzyme_14_Geneatlas_id:
AK2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:362

# Metabolic_Enzyme_14_PDB_ID:
2AK2

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Mitochondrion; mitochondrial intermembrane space

# Metabolic_Enzyme_14_Gene_Sequence:
>720 bp
ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG
CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT
GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA
GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG
GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC
TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG
AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATCCGAAGAATCACA
GGAAGGCTGATTCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAA
GAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAA
AAGGCCTTGAAAATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTAC
TACAGGAAACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTC
GCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATGTAAAGACTTGGTTATGTTTATCTAA


# Metabolic_Enzyme_14_GenBank_ID_Gene:
U39945

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_14_Locus:
1p34

# Metabolic_Enzyme_14_SNPs:
rs12116440; rs998664; rs6884; rs2075986; rs2268691; rs3766810; rs2268692; rs10914643; rs2268693; rs10798924; rs13376642; rs10914647; rs1012884; rs10914649; rs11799675; rs11591185; rs10914645; rs7521588; rs10753271; rs10914642; rs3766811; rs10914646; rs11799809; rs12409924; rs12082671; rs2038023; rs10914644; rs11576688; rs10914648; rs7523652; rs16835243; rs10399832; rs9970553; rs12095142; rs1534892; rs1534893; rs1804813; rs35731438; rs41301072; rs1003961; rs11015; rs4045165; rs34560906; rs4045171; rs1058771; rs34574865; rs11509; rs4045169; rs41265879; rs3958633; rs12568596; rs34253212; rs4045170; rs2335940; rs41265877; rs12137139; rs35960731; rs12041090; rs35607181; rs35955745; rs34516962; rs10218504; rs34219707; rs34411166; rs10399747; rs34489539; rs34651021; rs35543633; rs34048886; rs34760662; rs4951776; rs35310810; rs35291940; rs28546883; rs2284806; rs35111200; rs34622889; rs12117130; rs12116791; rs2300663; rs12096662; rs12096720; rs34804406; rs12117444; rs35815280; rs35303597; rs35256792; rs36095882; rs35769076; rs10753272; rs10914641; rs10914650; rs11810032; rs16835240; rs34118272; rs35604827; rs4561002; rs6660919; rs9633313

# Metabolic_Enzyme_14_General_References:
8843353; 9504408; 9434148

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5842

# Metabolic_Enzyme_15_Name:
Long-chain-fatty-acid--CoA ligase 4

# Metabolic_Enzyme_15_Synonyms:
Long-chain acyl-CoA synthetase 4; LACS 4

# Metabolic_Enzyme_15_Gene_Name:
ACSL4

# Metabolic_Enzyme_15_Protein_Sequence:
>LongchainfattyacidCoA ligase 4
MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYR
SVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLIL
GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL
YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE
GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMT
GQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSK
GDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLC
NLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEV
TDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAED
YSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDN
ICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAM
KLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK

# Metabolic_Enzyme_15_Number_of_Residues:
711

# Metabolic_Enzyme_15_Molecular_Weight:
79189

# Metabolic_Enzyme_15_Theoretical_pI:
8.51

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates

# Metabolic_Enzyme_15_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_15_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_15_Signals:
1-23

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_15_GenBank_ID_Protein:
3158351

# Metabolic_Enzyme_15_SwissProt_ID:
ACSL4_HUMAN (O60488)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
ACSL4

# Metabolic_Enzyme_15_Geneatlas_id:
ACSL4

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3571

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_15_Gene_Sequence:
>2013 bp
ATGGCAAAGAGAATAAAAGCTAAGCCCACTTCAGACAAACCTGGAAGTCCATATCGCTCT
GTCACACACTTCGACTCACTAGCTGTAATAGACATCCCTGGAGCAGATACTCTGGATAAA
TTATTTGACCATGCTGTATCCAAGTTTGGGAAGAAGGACAGCCTTGGGACCAGGGAAATC
CTAAGTGAAGAAAATGAAATGCAGCCAAATGGAAAAGTTTTTAAGAAGTTAATTCTTGGG
AATTATAAATGGATGAACTATCTTGAAGTGAATCGCAGAGTGAATAACTTTGGTAGTGGA
CTCACTGCACTGGGACTAAAACCAAAGAACACCATTGCCATCTTCTGTGAGACCAGGGCC
GAATGGATGATTGCAGCACAGACCTGCTTTAAGTACAACTTTCCTCTTGTGACTTTATAT
GCCACACTTGGCAAAGAAGCAGTAGTTCATGGGCTAAATGAATCTGAGGCTTCCTATCTG
ATTACCAGTGTTGAACTTCTGGAAAGTAAACTTAAGACTGCATTGTTAGATATCAGTTGT
GTTAAACATATCATTTATGTGGACAATAAGGCTATCAATAAAGCAGAGTACCCTGAAGGA
TTTGAGATTCACAGCATGCAATCAGTAGAAGAGTTGGGATCTAACCCAGAAAACTTGGGC
ATTCCTCCAAGTAGACCAACGCCTTCAGACATGGCCATTGTTATGTATACTAGTGGTTCT
ACTGGCCGACCTAAGGGAGTGATGATGCATCATAGCAATTTGATAGCTGGAATGACAGGC
CAGTGTGAAAGAATACCTGGACTGGGACCGAAGGACACATATATTGGCTACTTGCCTTTG
GCTCATGTGCTAGAACTGACAGCAGAGATATCTTGCTTTACCTATGGCTGCAGGATTGGA
TATTCTTCTCCGCTTACACTCTCTGACCAGTCCAGCAAAATTAAAAAAGGAAGCAAAGGA
GACTGTACTGTACTGAAGCCCACACTTATGGCTGCTGTTCCGGAAATCATGGATAGAATT
TATAAGAATGTTATGAGCAAAGTCCAAGAGATGAATTATATTCAGAAAACTCTGTTCAAG
ATAGGGTATGATTACAAATTGGAACAGATCAAAAAGGGATATGATGCACCTCTTTGCAAT
CTGTTACTGTTTAAAAAGGTCAAGGCCCTGCTGGGAGGGAATGTCCGCATGATGCTGTCT
GGAGGGGCCCCGCTATCTCCTCAGACACACCGATTCATGAATGTCTGCTTCTGCTGCCCA
ATTGGCCAGGGTTATGGACTGACAGAATCATGTGGTGCTGGGACAGTTACTGAAGTAACT
GACTATACTACTGGCAGAGTTGGAGCACCTCTTATTTGCTGTGAAATTAAGCTAAAAGAC
TGGCAAGAAGGCGGTTATACAATTAATGACAAGCCAAACCCCAGAGGTGAAATCGTAATT
GGTGGACAGAACATCTCCATGGGATATTTTAAAAATGAAGAGAAAACAGCAGAAGATTAT
TCTGTGGATGAAAATGGACAAAGGTGGTTTTGCACTGGTGATATTGGAGAATTCCATCCC
GATGGATGTTTACAGATTATAGATCGTAAGAAAGATCTAGTGAAGTTACAAGCAGGAGAG
TATGTATCTCTTGGGAAAGTAGAAGCTGCACTGAAGAATTGTCCACTTATTGACAACATC
TGTGCTTTTGCCAAAAGTGATCAGTCCTATGTGATCAGTTTTGTGGTTCCTAACCAGAAA
AGGTTGACACTTTTGGCACAACAGAAAGGGGTAGAAGGAACTTGGGTTGATATCTGCAAT
AATCCTGCTATGGAAGCTGAAATACTGAAAGAAATTCGAGAAGCTGCAAATGCCATGAAA
TTGGAGCGATTTGAAATTCCAATCAAGGTTCGATTAAGCCCAGAGCCATGGACCCCTGAA
ACTGGTTTGGTAACTGATGCTTTCAAACTGAAAAGGAAGGAGCTGAGGAACCATTACCTC
AAAGACATTGAACGAATGTATGGGGGCAAATAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AF030555

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_15_Locus:
Xq22.3-q23

# Metabolic_Enzyme_15_SNPs:
rs2147518; rs5943421; rs4893538; rs5943427; rs1324805; rs1802109; rs5985760; rs5942832; rs4893536; rs5943418; rs6568270; rs5985761; rs5943414; rs5943423; rs10127341; rs5943420; rs7056314; rs5943425; rs4520340; rs5943416; rs5943426; rs5985400; rs10126612; rs5985404; rs5943424; rs12856122; rs5943419; rs5985403; rs5942830; rs839406; rs5943413; rs5985752; rs5985753; rs839407; rs11795780; rs5985399; rs7886473; rs5985398; rs7887981; rs11798398; rs866799; rs7888546; rs839408; rs5985751; rs839409; rs839402; rs5943408; rs5985754; rs839405; rs5985750; rs12156713; rs5943428; rs34221826; rs17853346; rs6655223; rs12835747; rs34702145; rs34583814; rs6643466; rs34685485; rs35513711; rs5985406; rs5943415; rs34231190; rs34571782; rs10574554; rs35928030; rs2038802; rs35191659; rs34694513; rs12847335; rs4893537; rs5985405; rs12010735; rs35077907; rs6643469; rs1063544; rs35736807; rs6643468; rs34379159; rs6643470; rs28663608; rs7057123; rs35038796; rs34773820; rs9699192; rs12383143; rs5943422; rs1555729; rs34867628; rs11552088; rs34826689; rs6643467; rs12844283; rs6643472; rs5985402; rs11322335; rs6643471; rs34058667; rs35186119; rs35218038; rs12389738; rs35144454; rs35175681; rs12011532; rs12857092; rs12856802; rs12857086; rs5985755; rs5943411; rs12856751; rs35072231; rs28624880; rs4442305; rs839403; rs41307405; rs839404; rs1103679; rs12834982; rs36115643; rs3831071; rs5943412; rs3788761; rs12687434; rs3886256; rs5985756; rs7884086; rs28567470; rs5985759; rs6655222; rs12688079; rs34597417; rs12846737; rs12835879; rs12687117; rs5985757; rs34910449; rs34210031; rs35262228; rs12689515; rs2281822; rs5942833; rs5943429; rs6568268; rs6643465; rs6655225; rs7057160; rs7881846; rs839401

# Metabolic_Enzyme_15_General_References:
9598324; 9480748; 11889465

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5843

# Metabolic_Enzyme_16_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

# Metabolic_Enzyme_16_Synonyms:
Cam-PDE 1A; 61 kDa Cam-PDE; hCam-1

# Metabolic_Enzyme_16_Gene_Name:
PDE1A

# Metabolic_Enzyme_16_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
AMGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYA
ASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFR
SIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFM
IYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTG
IMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL
MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMS
LILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG
FIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKG
SMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ

# Metabolic_Enzyme_16_Number_of_Residues:
535

# Metabolic_Enzyme_16_Molecular_Weight:
61253

# Metabolic_Enzyme_16_Theoretical_pI:
6.02

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Has a higher affinity for cGMP than for cAMP

# Metabolic_Enzyme_16_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_16_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
1151109

# Metabolic_Enzyme_16_SwissProt_ID:
PDE1A_HUMAN (P54750)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PDE1A

# Metabolic_Enzyme_16_Geneatlas_id:
PDE1A

# Metabolic_Enzyme_16_hgnc_id:
HGNC:8774

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_16_Gene_Sequence:
>1608 bp
ATGGGGTCTAGTGCCACAGAGATTGAAGAATTGGAAAACACCACTTTTAAGTATCTTACA
GGAGAACAGACTGAAAAAATGTGGCAGCGCCTGAAAGGAATACTAAGATGCTTGGTGAAG
CAGCTGGAAAGAGGTGATGTTAACGTCGTCGACTTAAAGAAGAATATTGAATATGCGGCA
TCTGTGCTGGAAGCAGTTTATATCGATGAAACAAGAAGACTTCTGGATACTGAAGATGAG
CTCAGTGACATTCAGACTGACTCAGTCCCATCTGAAGTCCGGGACTGGTTGGCTTCTACC
TTTACACGGAAAATGGGGATGACAAAAAAGAAACCTGAGGAAAAACCAAAATTTCGGAGC
ATTGTGCATGCTGTTCAAGCTGGAATTTTTGTGGAAAGAATGTACCGAAAAACATATCAT
ATGGTTGGTTTGGCATATCCAGCAGCTGTCATCGTAACATTAAAGGATGTTGATAAATGG
TCTTTCGATGTATTTGCCCTAAATGAAGCAAGTGGAGAGCATAGTCTGAAGTTTATGATT
TATGAACTGTTTACCAGATATGATCTTATCAACCGTTTCAAGATTCCTGTTTCTTGCCTA
ATCACCTTTGCAGAAGCTTTAGAAGTTGGTTACAGCAAGTACAAAAATCCATATCACAAT
TTGATTCATGCAGCTGATGTCACTCAAACTGTGCATTACATAATGCTTCATACAGGTATC
ATGCACTGGCTCACTGAACTGGAAATTTTAGCAATGGTCTTTGCTGCTGCCATTCATGAT
TATGAGCATACAGGGACAACAAACAACTTTCACATTCAGACAAGGTCAGATGTTGCCATT
TTGTATAATGATCGCTCTGTCCTTGAGAATCACCACGTGAGTGCAGCTTATCGACTTATG
CAAGAAGAAGAAATGAATATCTTGATAAATTTATCCAAAGATGACTGGAGGGATCTTCGG
AACCTAGTGATTGAAATGGTTTTATCTACAGACATGTCAGGTCACTTCCAGCAAATTAAA
AATATAAGAAACAGTTTGCAGCAGCCTGAAGGGATTGACAGAGCCAAAACCATGTCCCTG
ATTCTCCACGCAGCAGACATCAGCCACCCAGCCAAATCCTGGAAGCTGCATTATCGGTGG
ACCATGGCCCTAATGGAGGAGTTTTTCCTGCAGGGAGATAAAGAAGCTGAATTAGGGCTT
CCATTTTCCCCACTTTGTGATCGGAAGTCAACCATGGTGGCCCAGTCACAAATAGGTTTC
ATCGATTTCATAGTAGAGCCAACATTTTCTCTTCTGACAGACTCAACAGAGAAAATTGTT
ATTCCTCTTATAGAGGAAGCCTCAAAAGCCGAAACTTCTTCCTATGTGGCAAGCAGCTCA
ACCACCATTGTGGGGTTACACATTGCTGATGCACTAAGACGATCAAATACAAAAGGCTCC
ATGAGTGATGGGTCCTATTCCCCAGACTACTCCCTTGCAGCAGTGGACCTGAAGAGTTTC
AAGAACAACCTGGTGGACATCATTCAGCAGAACAAAGAGAGGTGGAAAGAGTTAGCTGCA
CAAGAAGCAAGAACCAGTTCACAGAAGTGTGAGTTTATTCATCAGTAA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U40370

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q32.1

# Metabolic_Enzyme_16_SNPs:
rs6749969; rs6734868; rs1432531; rs1999; rs28364747; rs2368253; rs1196064; rs1430163; rs833149; rs2623431; rs964758; rs833182; rs1430143; rs2623423; rs1432534; rs964757; rs833166; rs833142; rs1864852; rs1430142; rs718448; rs1196065; rs1383898; rs1438072; rs1432520; rs833175; rs2623421; rs1430145; rs2368252; rs1367201; rs1347079; rs2568664; rs1367202; rs1196062; rs1988750; rs2368301; rs1864850; rs1432523; rs1991765; rs2128043; rs1196060; rs833152; rs1370666; rs1370669; rs1196058; rs1430162; rs1835881; rs1864849; rs1432517; rs2568672; rs2623436; rs1196059; rs2860078; rs2887202; rs1432521; rs1864855; rs1946815; rs2623438; rs2568675; rs833178; rs2568667; rs1432522; rs833123; rs833115; rs1564542; rs2170403; rs833122; rs833179; rs1560371; rs10931010; rs12474760; rs2128046; rs10931015; rs1992183; rs2887217; rs7598327; rs994155; rs1864847; rs833134; rs11690832; rs833125; rs4629124; rs10930998; rs12468232; rs1864853; rs10497604; rs2368296; rs1432533; rs3769801; rs833148; rs10931009; rs1432515; rs12466618; rs11683479; rs2118484; rs1438065; rs3769806; rs1196074; rs12624259; rs1560370; rs2568663; rs4666828; rs1595450; rs12465662; rs1946602; rs833124; rs2368294; rs12328342; rs4503956; rs10931016; rs7583421; rs6741055; rs2887218; rs10930999; rs6433976; rs4644985; rs10181526; rs2577659; rs3769788; rs11689230; rs1125184; rs7597711; rs1991596; rs300885; rs6740124; rs6706326; rs7589989; rs6759303; rs2128042; rs6760317; rs833118; rs7581210; rs10931002; rs1344772; rs833145; rs6719036; rs13034133; rs2368255; rs12693302; rs12474820; rs11891890; rs10193166; rs1430144; rs4643498; rs10930997; rs7593755; rs12468743; rs12693301; rs10931013; rs11884886; rs13036034; rs1430160; rs6759413; rs9789764; rs6433974; rs1481630; rs6740244; rs7597380; rs1370668; rs4666585; rs833126; rs2164861; rs1346775; rs6721984; rs833130; rs2887200; rs11679657; rs6759450; rs3769809; rs991927; rs10931022; rs10178586; rs833113; rs1196067; rs10930993; rs1594615; rs10197295; rs4666836; rs12996836; rs2623437; rs2368298; rs10184548; rs1430157; rs10931008; rs2368256; rs6718589; rs10206828; rs753289; rs1991766; rs1430159; rs12612546; rs6433959; rs833119; rs934260; rs10206325; rs1438069; rs1370667; rs4666835; rs3754929; rs11902391; rs1594304; rs1438071; rs724851; rs1864445; rs4666819; rs6758334; rs9653242; rs2577661; rs11899043; rs833141; rs2623409; rs11676337; rs1594617; rs10930991; rs6736414; rs7558737; rs3769791; rs1196066; rs7569537; rs4666815; rs1021090; rs833168; rs7585752; rs1438070; rs833140; rs2082135; rs9784041; rs4666582; rs1370665; rs2195878; rs12473534; rs12475647; rs10169102; rs11883669; rs10931012; rs12622714; rs2368295; rs12477696; rs13400536; rs12474371; rs10204284; rs4666817; rs833156; rs6433973; rs12477494; rs11892984; rs6734447; rs13406145; rs12693300; rs934261; rs1594305; rs7606428; rs7557419; rs1368216; rs17343416; rs2568681; rs1367203; rs11674335; rs11692649; rs16823044; rs13400054; rs4572561; rs7592850; rs934264; rs833135; rs6715692; rs1367204; rs1210652; rs6750552; rs11684934; rs1560372; rs7571503; rs11690257; rs2128045; rs16823102; rs833176; rs11686025; rs6433958; rs833138; rs3769803; rs4496292; rs12693299; rs17356152; rs11887327; rs10497605; rs12467240; rs2623432; rs12693308; rs12475048; rs12468346; rs13410344; rs13392487; rs7562805; rs12616214; rs6747821; rs12621579; rs7599577; rs4666827; rs4335909; rs11682598; rs11898512; rs11894978; rs17265405; rs1432518; rs2368278; rs1560375; rs10197136; rs11691411; rs11886669; rs2082136; rs1564543; rs11887703; rs17343395; rs6728410; rs1897104; rs1864851; rs4666587; rs10931020; rs16823124; rs833162; rs2368299; rs864417; rs2368300; rs17265322; rs833154; rs833146; rs12479259; rs12617420; rs6760364; rs6433964; rs11900878; rs16823319; rs833117; rs6728235; rs10186868; rs1196069; rs10803955; rs1432519; rs2368254; rs2623410; rs9288080; rs1594618; rs1967008; rs13417045; rs16823047; rs2368277; rs12469500; rs3769796; rs2623430; rs3769800; rs11684406; rs6757164; rs2170400; rs10174383; rs12989198; rs7574051; rs2170402; rs16823122; rs1021092; rs6724256; rs11892848; rs10931000; rs10497601; rs16822799; rs11884145; rs1471587; rs2368297; rs16823179; rs12693305; rs1583112; rs6726121; rs17356200; rs3769802; rs17356207; rs10497597; rs6740401; rs16823171; rs13432152; rs10497595; rs13417404; rs10171703; rs1842640; rs6433960; rs6433963; rs3769811; rs7585427; rs12467526; rs11895738; rs1347732; rs1196072; rs3769789; rs3769810; rs12617844; rs9288081; rs2368302; rs2568673; rs17366198; rs11675519; rs12994855; rs12477627; rs1549870; rs10207132; rs10497600; rs6740226; rs12693304; rs4666584; rs7595025; rs16823163; rs10497602; rs1430146; rs10930995; rs11678230; rs1595448; rs6740889; rs4666851; rs7567023; rs3820963; rs7563753; rs7578466; rs10931014; rs1196070; rs12693303; rs12466937; rs10169895; rs11681840; rs3769792; rs17356303; rs12470644; rs3940474; rs833174; rs1594614; rs11891405; rs11677155; rs13420620; rs833180; rs2276612; rs833128; rs11895090; rs2099185; rs10931017; rs11888602; rs833177; rs17356166; rs17265294; rs10209382; rs10497603; rs11690037; rs16823254; rs12693307; rs833170; rs7567423; rs7597921; rs1346773; rs16823201; rs1438068; rs1595449; rs1897472; rs2368280; rs4666846; rs1430141; rs4666578; rs12616751; rs10497599; rs17366503; rs4480955; rs7578703; rs10206152; rs10931011; rs9332425; rs3856410; rs833160; rs2195611; rs16823011; rs7422491; rs10497598; rs16823106; rs3769794; rs17264929; rs833158; rs833120; rs11677310; rs833181; rs10174618; rs7606875; rs12693306; rs1595445; rs2623435; rs6733603; rs6733935; rs6751445; rs11686989; rs1864854; rs17457136; rs2887199; rs11687469; rs11678901; rs10196288; rs6720739; rs4666845; rs2568674; rs2196695; rs11893572; rs7601804; rs4666583; rs10930992; rs7561341; rs10180233; rs1594306; rs11678804; rs13410259; rs7591292; rs833114; rs4666579; rs2368276; rs833159; rs1196073; rs2128047; rs16823207; rs17457303; rs6729400; rs833116; rs2448980; rs13385209; rs2577649; rs2623418; rs12990168; rs13399478; rs12470722; rs1898591; rs833155; rs2887207; rs4666844; rs2568677; rs7597403; rs2118485; rs7591416; rs6720942; rs2623422; rs2053270; rs1121403; rs12612357; rs13020976; rs16822749; rs2577658; rs12616179; rs4594404; rs6760589; rs16823184; rs16822776; rs10197132; rs6747822; rs11678948; rs7606009; rs16823203; rs12468333; rs1438073; rs2623417; rs16823235; rs9711046; rs1383899; rs16823222; rs2568661; rs12622605; rs2368279; rs6726324; rs6718641; rs2568684; rs16823233; rs16823317; rs17265027; rs16823287; rs6728985; rs6761081; rs10198076; rs4091077; rs16823182; rs1481629; rs16822886; rs833165; rs34053285; rs6709051; rs12616229; rs16823234; rs4666834; rs16823275; rs3820962; rs6730984; rs2623412; rs2568670; rs9753060; rs16823678; rs16822961; rs12475637; rs16822915; rs11690853; rs12987958; rs16823010; rs4666841; rs833147; rs2217614; rs2438288; rs1837167; rs4630732; rs1196068; rs4666850; rs1438075; rs2118487; rs833139; rs13030388; rs16823686; rs17265041; rs6751461; rs16823220; rs11687076; rs2448982; rs17265061; rs11685463; rs1432525; rs10165500; rs9753059; rs16823199; rs17343304; rs1430150; rs12988258; rs10182266; rs17343311; rs34103461; rs17356331; rs11677543; rs6744832; rs16823243; rs4555308; rs13388594; rs16822745; rs7578481; rs6433970; rs6714282; rs16823257; rs4383292; rs833127; rs17265166; rs13428559; rs11681620; rs1438074; rs17264796; rs1344773; rs300884; rs12470801; rs17457344; rs1196063; rs1560374; rs3769778; rs13400663; rs13397213; rs6729405; rs2448981; rs10188331; rs2568687; rs13388711; rs833144; rs833163; rs17356296; rs12470124; rs4666586; rs10200242; rs16822895; rs6717783; rs3769805; rs12465755; rs1583114; rs12478553; rs13388735; rs2577651; rs10181570; rs13383296; rs12472694; rs4583416; rs833173; rs17265189; rs16822899; rs12615015; rs16823227; rs17343318; rs724376; rs17356463; rs10209868; rs2568665; rs7589555; rs17595927; rs6754260; rs2568680; rs1430161; rs6725769; rs17265350; rs17410250; rs866732; rs1430147; rs10199957; rs10185985; rs3769790; rs1432516; rs2623426; rs4666820; rs6705950; rs4666824; rs4666829; rs11677136; rs2082134; rs1430148; rs2623420; rs17265203; rs6718531; rs12469046; rs711807; rs6741105; rs2099184; rs4666840; rs6720671; rs833151; rs16823249; rs7592388; rs10209197; rs4583421; rs2577663; rs13024682; rs13398665; rs7588289; rs2170401; rs2887215; rs11695445; rs10171911; rs12478132; rs11674733; rs4318355; rs4666823; rs4632308; rs12614214; rs2568666; rs16823156; rs10930996; rs17264887; rs10201929; rs17264880; rs1542584; rs2577652; rs2623427; rs10185590; rs1988751; rs7595111; rs6721940; rs11677709; rs1430158; rs11899588; rs7567112; rs833131; rs2568671; rs711806; rs11903131; rs13407156; rs833153; rs1595446; rs17356214; rs10189043; rs2568683; rs16823229; rs12473820; rs4018737; rs865001; rs17457323; rs13035314; rs12465757; rs833157; rs17595863; rs6758298; rs10803956; rs11683084; rs16823120; rs16822892; rs833167; rs16822918; rs2438290; rs16823168; rs6747766; rs4666580; rs7589514; rs4666830; rs16823151; rs1864848; rs10202082; rs3769797; rs10195640; rs2568676; rs11685510; rs4666838; rs4666822; rs4666826; rs16823150; rs17264894; rs16822889; rs10931018; rs833172; rs11887150; rs10497596; rs16823277; rs3769786; rs7561075; rs11676559; rs13394418; rs16823285; rs4018730; rs167284; rs833171; rs2623439; rs17457164; rs9798118; rs16823236; rs6734150; rs13403591; rs10207047; rs2577660; rs964756; rs16822768; rs711808; rs17265384; rs12621190; rs4666837; rs10198216; rs13406342; rs17366218; rs10200025; rs833150; rs16823158; rs1438067; rs9711070; rs4666825; rs6720583; rs2568660; rs10175845; rs1351492; rs2128044; rs10931021; rs865578; rs7560332; rs13003148; rs3769779; rs4666577; rs2303890; rs3754928; rs1921153; rs12105839; rs17649281; rs1057945; rs5836825; rs3210428; rs2276613; rs34657010; rs1484; rs34392771; rs1560373; rs35704530; rs13016087; rs2568662; rs28870438; rs1142499; rs7591196; rs3063101; rs10204911; rs13021857; rs35927091; rs10195097; rs10184869; rs1438066; rs35087060; rs34269574; rs5836832; rs34206320; rs34200314; rs7608624; rs34318365; rs36099854; rs11376015; rs35771061; rs3835906; rs13404757; rs13410703; rs13397815; rs34744930; rs13391931; rs10667573; rs35084880; rs35321986; rs34436167; rs35061201; rs34978102; rs16823159; rs35932804; rs34981789; rs35467151; rs34523452; rs35075463; rs36067516; rs34934382; rs13025145; rs28369479; rs33922098; rs16822795; rs11336735; rs13418736; rs11376014; rs9712068; rs35204121; rs34884579; rs35019955; rs10432427; rs35032256; rs833164; rs34538059; rs2118486; rs33987953; rs35764937; rs4544391; rs6728245; rs4505483; rs35247872; rs35851840; rs5836827; rs3769787; rs13411042; rs13402461; rs16822784; rs2577648; rs34602848; rs6707322; rs35760311; rs1196075; rs34257247; rs16822812; rs4666818; rs35372886; rs3835908; rs1142496; rs5004861; rs17264817; rs34418595; rs2217424; rs36079245; rs34716524; rs5836830; rs13403996; rs1346774; rs35239912; rs33944928; rs34241797; rs3835905; rs13405173; rs10546002; rs10182192; rs13020356; rs10679939; rs2163695; rs35081866; rs35642510; rs9752179; rs6736660; rs11329645; rs12623018; rs34497200; rs10661926; rs13012803; rs6720202; rs34799454; rs35092643; rs12995785; rs34735471; rs13015852; rs16823072; rs6712992; rs34157460; rs7581170; rs6759207; rs35485908; rs34120183; rs11351148; rs34225086; rs35394100; rs6740676; rs35825733; rs35806345; rs34219838; rs3209104; rs28569979; rs4666581; rs28701896; rs34165544; rs11677223; rs35777140; rs12991791; rs3835907; rs11333920; rs34505391; rs35030431; rs28420082; rs2195880; rs6729094; rs833132; rs35600244; rs10649015; rs6147058; rs36120860; rs13028649; rs13413938; rs36047430; rs35608334; rs3062171; rs35164921; rs34487617; rs12988815; rs1196061; rs35122269; rs13012388; rs35843666; rs7601239; rs34665608; rs4666833; rs34868101; rs13410842; rs35797263; rs5836834; rs13001576; rs6734332; rs35829416; rs34388968; rs11675803; rs11348029; rs300882; rs1816654; rs3209105; rs35327523; rs35226392; rs16822851; rs5836829; rs9798131; rs13416498; rs34670464; rs34307690; rs35470057; rs28807785; rs35161948; rs34156888; rs34185607; rs34636057; rs11394200; rs34019486; rs10632753; rs13393694; rs16822739; rs35085933; rs12470794; rs35219304; rs35928664; rs34461539; rs6433975; rs9678854; rs35176528; rs6748063; rs11349101; rs11442872; rs10173255; rs13017441; rs34780932; rs34850993; rs3940475; rs6761344; rs12104898; rs35169307; rs28439754; rs35840738; rs34929129; rs10529301; rs34483465; rs34669140; rs36010429; rs833133; rs2887208; rs36059127; rs866733; rs5836833; rs9712067; rs833136; rs13035123; rs34344623; rs3769795; rs35131293; rs16822753; rs35577192; rs2577654; rs36212772; rs12053027; rs833143; rs34167707; rs28820373; rs10595375; rs13033301; rs922732; rs2568682; rs35196240; rs4369824; rs4666852; rs34173972; rs10176807; rs34393660; rs13402892; rs34377459; rs10626467; rs11349102; rs34133532; rs34963796; rs34609810; rs11420985; rs34296220; rs11681511; rs34674764; rs28773524; rs34846500; rs10691371; rs28520932; rs35187563; rs16822777; rs34224743; rs300883; rs34172306; rs34236186; rs35764684; rs11379999; rs13025112; rs11375672; rs10590540; rs16823164; rs13399931; rs34299616; rs2577655; rs2577664; rs36121688; rs1835880; rs3062169; rs34348001; rs300887; rs4144788; rs12991955; rs34933688; rs13407411; rs41371048; rs34592316; rs34213407; rs34146836; rs12474205; rs16822938; rs922731; rs35256698; rs11688020; rs35022988; rs12104910; rs34388312; rs35336295; rs10209574; rs13410856; rs34087191; rs35208422; rs13387701; rs1432532; rs10601832; rs13430558; rs5836836; rs35607749; rs34346085; rs34057444; rs28408366; rs28836623; rs35242356; rs13004142; rs28828218; rs11340321; rs2368275; rs6755854; rs35361731; rs833169; rs16822963; rs10552886; rs36094848; rs34164863; rs13008937; rs4018725; rs1469638; rs1142494; rs7423835; rs300881; rs34889222; rs35002581; rs13013571; rs34988767; rs13424576; rs35852909; rs1595447; rs16822803; rs28666451; rs4144787; rs1070197; rs10688734; rs2438291; rs16823231; rs35368292; rs34226756; rs35220243; rs6760081; rs9711065; rs11399196; rs2082137; rs34920104; rs34966344; rs10713794; rs3209106; rs35811506; rs10931019; rs13400207; rs36105371; rs10177393; rs35509004; rs1978701; rs13415219; rs6760333; rs35831447; rs1142493; rs12999222; rs7606819; rs35650373; rs35320184; rs10557808; rs12996626; rs11408095; rs35174498; rs34076997; rs34640250; rs16822975; rs5836835; rs7423272; rs34245450; rs10203701; rs3063250; rs10188098; rs6147057; rs2436223; rs34863201; rs34103776; rs35115213; rs1196071; rs16822843; rs34713018; rs34586550; rs7425918; rs3835909; rs13013920; rs34863701; rs35574967; rs13424577; rs6761816; rs300886; rs10710872; rs34237746; rs35357239; rs16822827; rs300889; rs3769798; rs10586379; rs2116637; rs866238; rs35885421; rs3063230; rs13384332; rs34509021; rs34758055; rs833121; rs34957815; rs35323523; rs28409316; rs1595444; rs11319157; rs34530868; rs11296923; rs35392282; rs28715871; rs12991803; rs4018724; rs34681555; rs34371581; rs35441240; rs2577653; rs36076255; rs34984539; rs35111823; rs10664174; rs34245807; rs28584604; rs35648980; rs34968173; rs6759848; rs34116983; rs2116636; rs7579614; rs35587614; rs35425419; rs300888; rs34132592; rs35774261; rs34921672; rs34853053; rs35202585; rs36010777; rs35453967; rs2623424; rs10716042; rs11314814; rs34710050; rs34134272; rs35055482; rs35368132; rs7424126; rs34034865; rs13387603; rs13388823; rs35927887; rs36032833; rs11431216; rs35840080; rs10549191; rs28483774; rs9789594; rs13387691; rs13421087; rs34661945; rs10592313; rs34302168; rs34157620; rs34107698; rs28627441; rs4497838; rs11444937; rs12053043; rs2887216; rs12991790; rs3948378; rs5836826; rs34010252; rs862914; rs35884831; rs10170443; rs34823032; rs3063102; rs35502150; rs1837166; rs35617426; rs4992784; rs1871805; rs34343334; rs34450309; rs9653243; rs13420210; rs9798127; rs16823040; rs36202824; rs10597484; rs13013738; rs3830245; rs11300978; rs35182213; rs11351500; rs35809203; rs34641892; rs34558843; rs6725460; rs2116635; rs35245337; rs10617879; rs13026153; rs6719467; rs34326436; rs34145505; rs1142495; rs10668596; rs35156194; rs12472990; rs34384812; rs35828806; rs833161; rs34841932; rs1842639; rs11405472; rs6731653; rs34878038; rs35827784; rs4666821; rs11420821; rs2438289; rs16823144; rs5836837; rs1430149; rs4425048; rs16822903; rs34934165; rs34382403; rs34234948; rs9678855; rs6736970; rs11414637; rs35139583; rs3769799; rs6759212; rs1383900; rs2568686; rs35067674; rs6747943; rs34461180; rs35248394; rs34181578; rs10197337; rs11676428; rs1196057; rs12464556; rs13001068; rs13027181; rs1347081; rs1368217; rs1368218; rs1368219; rs1368220; rs1368221; rs1432528; rs1432529; rs17649232; rs2115863; rs2217616; rs4257360; rs6711862; rs6726543; rs6756014; rs720245; rs7580253; rs7584728; rs7592780

# Metabolic_Enzyme_16_General_References:
8557689; 11342109; 11747989

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5844

# Metabolic_Enzyme_17_Name:
Ubiquitin-conjugating enzyme E2 D1

# Metabolic_Enzyme_17_Synonyms:
Ubiquitin-protein ligase D1; Ubiquitin carrier protein D1; UbcH5; Ubiquitin- conjugating enzyme E2-17 kDa 1; E2(17KB 1

# Metabolic_Enzyme_17_Gene_Name:
UBE2D1

# Metabolic_Enzyme_17_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D1
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY
PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PDIAQIYKSDKEKYNRHAREWTQKYAM

# Metabolic_Enzyme_17_Number_of_Residues:
147

# Metabolic_Enzyme_17_Molecular_Weight:
16602

# Metabolic_Enzyme_17_Theoretical_pI:
7.50

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_17_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_17_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_17_GenBank_ID_Protein:
460810

# Metabolic_Enzyme_17_SwissProt_ID:
UB2D1_HUMAN (P51668)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UBE2D1

# Metabolic_Enzyme_17_Geneatlas_id:
UBE2D1

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12474

# Metabolic_Enzyme_17_PDB_ID:
1Z2U

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Not Available

# Metabolic_Enzyme_17_Gene_Sequence:
>444 bp
ATGGCGCTGAAGAGGATTCAGAAAGAATTGAGTGATCTACAGCGCGATCCACCTGCTCAC
TGTTCAGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCCACTATTATGGGGCCT
CCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGATTAT
CCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGT
AATGGAAGTATTTGTCTCGATATTCTGAGGTCACAATGGTCACCAGCTCTGACTGTATCA
AAAGTTTTATTGTCCATATGTTCTCTACTTTGTGATCCTAATCCAGATGACCCCTTAGTA
CCAGATATTGCACAAATCTATAAATCAGACAAAGAAAAATACAACAGACATGCAAGAGAA
TGGACTCAGAAATATGCAATGTAA

# Metabolic_Enzyme_17_GenBank_ID_Gene:
X78140

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_17_Locus:
10q11.2-q21

# Metabolic_Enzyme_17_SNPs:
rs7084674; rs1905455; rs1963927; rs10826174; rs11006121; rs4948291; rs10733980; rs4145785; rs11593650; rs3802699; rs10509089; rs11599360; rs7907725; rs10826172; rs9663811; rs7907716; rs10826173; rs11006122; rs7912527; rs16912161; rs16912155; rs2306605; rs11006113; rs11006120; rs7069613; rs12250046; rs16912166; rs11818745; rs16912153; rs11597042; rs16912160; rs12255735; rs7067670; rs28365823; rs34913574; rs11336978; rs34415625; rs12768363; rs35713196; rs35409288; rs12259285; rs11285375; rs36085642; rs34565317; rs10708236; rs34044230; rs34007991; rs34893503; rs35112740; rs11006115; rs12358567; rs34101372; rs11006123; rs11006117; rs33976064; rs11595502; rs35745962; rs11597039; rs7080053; rs35662901; rs34658838; rs11284386; rs3885750; rs41307530; rs34305911; rs35324479; rs34832174; rs41307528; rs5785315; rs7905938; rs12245963; rs1905456; rs12358693; rs34790413; rs12766129; rs11301989; rs34574089; rs34350845; rs1007915; rs10826175; rs11006111; rs11006112; rs11006124; rs12241885; rs12262648; rs16912171; rs16912172; rs1994174; rs4439463; rs7085229; rs7085740; rs7086017

# Metabolic_Enzyme_17_General_References:
8090726; 11389839

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5507

# Metabolic_Enzyme_18_Name:
Phenylalanyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_18_Synonyms:
Phenylalanine--tRNA ligase; PheRS

# Metabolic_Enzyme_18_Gene_Name:
FARS2

# Metabolic_Enzyme_18_Protein_Sequence:
>PhenylalanyltRNA synthetase, mitochondrial precursor
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF

# Metabolic_Enzyme_18_Number_of_Residues:
451

# Metabolic_Enzyme_18_Molecular_Weight:
52357

# Metabolic_Enzyme_18_Theoretical_pI:
7.48

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_18_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_18_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_18_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_18_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF03147:FDX-ACB;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_18_GenBank_ID_Protein:
3983103

# Metabolic_Enzyme_18_SwissProt_ID:
SYFM_HUMAN (O95363)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
FARS2

# Metabolic_Enzyme_18_Geneatlas_id:
FARS2

# Metabolic_Enzyme_18_hgnc_id:
HGNC:21062

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Mitochondrion; mitochondrial matrix (Potential)

# Metabolic_Enzyme_18_Gene_Sequence:
>1356 bp
ATGGTGGGCTCAGCTCTCAGGAGAGGTGCCCATGCATATGTCTACCTGGTGAGTAAGGCC
AGTCACATCTCCAGAGGCCATCAGCACCAGGCCTGGGGATCGAGGCCTCCTGCAGCAGAG
TGTGCCACCCAAAGAGCTCCAGGCAGTGTGGTGGAGCTGCTGGGCAAATCCTACCCTCAG
GACGACCACAGCAACCTCACCCGGAAGGTCCTCACCAGAGTTGGCAGGAACCTGCACAAC
CAGCAGCATCACCCTCTGTGGCTGATCAAGGAGAGGGTGAAGGAGCACTTCTACAAGCAG
TATGTGGGCCGCTTTGGGACCCCGTTGTTCTCGGTCTACGACAACCTTTCTCCAGTGGTC
ACGACCTGGCAGAACTTTGACAGCCTGCTCATCCCAGCTGATCACCCCAGCAGGAAGAAG
GGGGACAACTATTACCTGAATCGGACTCACATGCTGAGAGCGCACACGTCTGCACACCAG
TGGGACTTGCTGCACGCGGGACTGGATGCCTTCCTGGTGGTGGGTGATGTCTACAGGCGT
GACCAGATCGACTCCCAGCACTACCCTATTTTCCACCAGCTGGAGGCCGTGCGGCTCTTC
TCCAAGCATGAGTTATTTGCTGGTATAAAGGATGGAGAAAGCCTGCAGCTCTTTGAACAA
AGTTCTCGCTCTGCGCATAAACAAGAGACACACACCATGGAGGCCGTGAAGCTTGTAGAG
TTTGATCTTAAGCAAACGCTTACCAGGCTCATGGCACATCTTTTTGGAGATGAGCTGGAG
ATAAGATGGGTAGACTGCTACTTCCCTTTTACACATCCTTCCTTTGAGATGGAGATCAAC
TTTCATGGAGAATGGCTGGAAGTTCTTGGCTGCGGGGTGATGGAACAACAACTGGTCAAT
TCAGCTGGTGCTCAAGACCGAATCGGCTGGGCTTTTGGCCTAGGATTAGAAAGGCTAGCC
ATGATCCTCTACGACATCCCTGATATCCGTCTCTTCTGGTGTGAGGACGAGCGCTTCCTG
AAGCAGTTCTGTGTATCCAACATTAATCAGAAGGTGAAGTTTCAGCCTCTTAGCAAATAT
CCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGAT
TTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGAC
AAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCAC
ATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCT
GCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF097441

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_18_Locus:
6p25.1

# Metabolic_Enzyme_18_SNPs:
Not Available

# Metabolic_Enzyme_18_General_References:
10329163; 14574404

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5845

# Metabolic_Enzyme_19_Name:
GTP:AMP phosphotransferase mitochondrial

# Metabolic_Enzyme_19_Synonyms:
Adenylate kinase 3; AK3; Adenylate kinase 3 alpha-like 1

# Metabolic_Enzyme_19_Gene_Name:
AK3

# Metabolic_Enzyme_19_Protein_Sequence:
>GTP:AMP phosphotransferase mitochondrial
MGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFI
DQGKLIPDDVMTRLALHELKNLTQYSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEV
IKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQT
KPVLEYYQKKGVLETFSGTETNKIWPYVYAFLQTKVPQRSQKASVTP

# Metabolic_Enzyme_19_Number_of_Residues:
227

# Metabolic_Enzyme_19_Molecular_Weight:
25566

# Metabolic_Enzyme_19_Theoretical_pI:
9.64

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
NTP + AMP = NDP + ADP

# Metabolic_Enzyme_19_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_19_Reaction:
nucleoside triphosphate + AMP = nucleoside diphosphate + ADP

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 2.7.4.10

# Metabolic_Enzyme_19_GenBank_ID_Protein:
6518533

# Metabolic_Enzyme_19_SwissProt_ID:
KAD3_HUMAN (Q9UIJ7)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
AK3

# Metabolic_Enzyme_19_Geneatlas_id:
AK3

# Metabolic_Enzyme_19_hgnc_id:
HGNC:17376

# Metabolic_Enzyme_19_PDB_ID:
2AK3

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_19_Gene_Sequence:
>684 bp
ATGGGGGCGTCGGGGCGGCTGCTGCGAGCGGTGATCATGGGGGCCCCGGGCTCGGGCAAG
GGCACCGTGTCGTCCCGCATCACTACACACTTCGAGCTGAAGCACCTCTCCCGCGGGGAC
CTGCTCCGGGACAACATGCTGCGGGGCACAGAAATTGGCGTGTTAGCCCAGGCTTTCATT
GACCAAGGGAAACTCATCCCAGATTATGTCACGACTCGGCTGGCCCTTCATGAGCTGAAA
AACCTCACCCAGTATAGCTGGCTGTTGGATGGTTTTCCAAGGACACTTCCACAGGCAGAA
GCCCTAGATAGAGCTTATCAGATCGACACAGTGATTAACCTGAATGTGCCCTTTGAGGTC
ATTAAACAACGCCTTACTGCTCGCTGGATTCATCCCGCCAGTGGCCGAGTCTATAACATT
GAATTCAACCCTCCCAAAACTGTGGGCATTGATGACCTGACTGGGGAGCCTCTCATTCAG
CGTGAGGATGATAAACCAGAGACGGTTATCAAGAGACTAAAGGCTTATGAAGACCAAACA
AAGCCAGTCCTGGAATATTACCAGAAAAAAGGGGTGTTGGAAACATTCTCCGGAACAGAA
ACCAACAAGATTTGGCCCTATGTATATGCTTTCCTACAAACTAAAGTTCCACAAAGAAGC
CAGAAAGCTTCAGTTACTCCATGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AB021870

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_19_Locus:
9p24.1-p24.3

# Metabolic_Enzyme_19_SNPs:
rs6915; rs7839; rs296826; rs611315; rs458853; rs387413; rs461283; rs465793; rs456374; rs6476897; rs10758645; rs6476896; rs7025342; rs7042425; rs407603; rs2274820; rs425797; rs439786; rs7029401; rs465514; rs412523; rs7025999; rs464159; rs2274821; rs12684274; rs407872; rs10815060; rs9299003; rs7874642; rs12685446; rs3847259; rs3858043; rs296827; rs499012; rs10116645; rs2989447; rs10118317; rs11795106; rs7033866; rs10118863; rs12684167; rs3847258; rs12683352; rs10758646; rs1756867; rs439021; rs403860; rs2150614; rs16921966; rs10122675; rs12684173; rs2039300; rs467215; rs3818669; rs435100; rs429491; rs6476904; rs10815062; rs2989446; rs2183668; rs382034; rs10122182; rs12683953; rs7850522; rs378470; rs7033631; rs296882; rs10974756; rs7862134; rs7036553; rs10122575; rs463684; rs466740; rs7036255; rs17761666; rs468822; rs12378955; rs393097; rs2183670; rs10974751; rs7029742; rs10974754; rs406632; rs7856334; rs10121986; rs10974761; rs371053; rs10117047; rs10124194; rs6476903; rs1756865; rs13295366; rs382481; rs10974746; rs7034145; rs456549; rs431438; rs9918953; rs4286995; rs7875108; rs10815063; rs296881; rs393421; rs525055; rs413530; rs10118925; rs10122113; rs7872160; rs10124193; rs10974749; rs4484749; rs10974759; rs6476898; rs403873; rs7871915; rs12156500; rs466300; rs10121478; rs4500134; rs459122; rs35554426; rs12341359; rs410951; rs16921989; rs10115632; rs12350463; rs10118291; rs439486; rs439660; rs434892; rs10124574; rs10974747; rs6476902; rs378117; rs1048020; rs389445; rs1009447; rs1556362; rs159878; rs377430; rs414762; rs12003384; rs376680; rs17717946; rs296823; rs440497; rs375743; rs3808855; rs3808857; rs301490; rs301491; rs301492; rs403347; rs370932; rs11539608; rs14887; rs11539606; rs10262; rs12351140; rs14886; rs1047899; rs10974744; rs8525; rs28809001; rs7861716; rs34206656; rs10974748; rs10122613; rs28522705; rs10974760; rs415732; rs35166076; rs34481130; rs376367; rs34529377; rs33948374; rs12686844; rs1272932; rs35843737; rs12376372; rs34826468; rs443706; rs374981; rs10124593; rs13292541; rs12379614; rs34480399; rs12347371; rs10121108; rs35845464; rs2776772; rs445641; rs384562; rs33935556; rs447785; rs417364; rs35400602; rs4394450; rs413085; rs12555579; rs28848001; rs35846560; rs34098407; rs12683000; rs28670065; rs10974755; rs412899; rs28848329; rs388886; rs395423; rs2183669; rs4615632; rs10974758; rs7469985; rs36018610; rs34927825; rs12683859; rs33963986; rs13286573; rs439241; rs4373574; rs35637803; rs12686842; rs7852798; rs439239; rs10120222; rs12348423; rs5896090; rs35865338; rs12349358; rs12377935; rs11525119; rs12380629; rs34296493; rs397673; rs452333; rs451496; rs691770; rs35562986; rs35812152; rs4615631; rs34432519; rs12551243; rs385952; rs28478331; rs35405123; rs28503502; rs426575; rs12379929; rs364618; rs439835; rs384599; rs13440206; rs4442190; rs375090; rs489533; rs35121164; rs1756866; rs445285; rs10974757; rs13292115; rs12377966; rs1756864; rs12686158; rs7857582; rs13285417; rs7038082; rs376373; rs12380644; rs376684; rs12379674; rs35711809; rs10974762; rs7028711; rs34013706; rs1011115; rs10114246; rs1044706; rs10815058; rs10974742; rs10974763; rs11790285; rs12337281; rs12341356; rs12352353; rs12352385; rs12376425; rs1331191; rs1331192; rs14731; rs16921872; rs16921873; rs16921877; rs1888639; rs2026916; rs2181341; rs2183654; rs296820; rs296870; rs296871; rs296872; rs296873; rs296875; rs296876; rs296877; rs296879; rs3174298; rs3736839; rs395927; rs396861; rs409801; rs415094; rs4742045; rs4742046; rs692523; rs7024121; rs7029336; rs7029799; rs7036014; rs7040759; rs7468066; rs7852137; rs914285

# Metabolic_Enzyme_19_General_References:
Not Available

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5846

# Metabolic_Enzyme_20_Name:
Tryptophanyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_20_Synonyms:
Tryptophan-- tRNA ligase; TrpRS; IFP53; hWRS

# Metabolic_Enzyme_20_Gene_Name:
WARS

# Metabolic_Enzyme_20_Protein_Sequence:
>TryptophanyltRNA synthetase, cytoplasmic
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKA
DCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRI
ERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFT
KWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDY
MGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR
TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIF
LTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDY
TSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ

# Metabolic_Enzyme_20_Number_of_Residues:
471

# Metabolic_Enzyme_20_Molecular_Weight:
53166

# Metabolic_Enzyme_20_Theoretical_pI:
6.15

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  tryptophan-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tryptophanyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_20_Specific_Function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_20_Pathway:
map00380  Tryptophan metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_20_Reaction:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_20_Signals:
None

# Metabolic_Enzyme_20_Transmembrane_Regions:
None

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 6.1.1.2

# Metabolic_Enzyme_20_GenBank_ID_Protein:
184657

# Metabolic_Enzyme_20_SwissProt_ID:
SYWC_HUMAN (P23381)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
WARS

# Metabolic_Enzyme_20_Geneatlas_id:
WARS

# Metabolic_Enzyme_20_hgnc_id:
HGNC:12729

# Metabolic_Enzyme_20_PDB_ID:
1R6T

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_20_Gene_Sequence:
>1416 bp
ATGCCCAACAGTGAGCCCGCATCTCTGCTGGAGCTGTTCAACAGCATCGCCACACAAGGG
GAGCTCGTAAGGTCCCTCAAAGCGGGAAATGCGTCAAAGGATGAAATTGATTCTGCAGTA
AAGATGTTGGTGTCATTAAAAATGAGCTACAAAGCTGCCGCGGGGGAGGATTACAAGGCT
GACTGTCCTCCAGGGAACCCAGCACCTACCAGTAATCATGGCCCAGATGCCACAGAAGCT
GAAGAGGATTTTGTGGACCCATGGACAGTACAGACAAGCAGTGCAAAAGGCATAGACTAC
GATAAGCTCATTGTTCGGTTTGGAAGTAGTAAAATTGACAAAGAGCTAATAAACCGAATA
GAGAGAGCCACCGGCCAAAGACCACACCACTTCCTGCGCAGAGGCATCTTCTTCTCACAC
AGAGATATGAATCAGGTTCTTGATGCCTATGAAAATAAGAAGCCATTTTATCTGTACACG
GGCCGGGGCCCCTCTTCTGAAGCAATGCATGTAGGTCACCTCATTCCATTTATTTTCACA
AAGTGGCTCCAGGATGTATTTAACGTGCCCTTGGTGATCCAGATGACGGATGACGAGAAG
TATCTGTGGAAGGACCTGACCCTGGACCAGGCCTATAGCTATGCTGTGGAGAATGCCAAG
GACATCATCGCCTGTGGCTTTGACATCAACAAGACTTTCATATTCTCTGACCTGGACTAC
ATGGGGATGAGCTCAGGTTTCTACAAAAATGTGGTGAAGATTCAAAAGCATGTTACCTTC
AACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTGGGAAGATCAGTTTT
CCTGCCATCCAGGCTGCTCCCTCCTTCAGCAACTCATTCCCACAGATCTTCCGAGACAGG
ACGGATATCCAGTGCCTTATCCCATGTGCCATTGACCAGGATCCTTACTTTAGAATGACA
AGGGACGTCGCCCCCAGGATCGGCTATCCTAAACCAGCCCTGTTGCACTCCACCTTCTTC
CCAGCCCTGCAGGGCGCCCAGACCAAAATGAGTGCCAGCGACCCCAACTCCTCCATCTTC
CTCACCGACACGGCCAAGCAGATCAAAACCAAGGTCAATAAGCATGCGTTTTCTGGAGGG
AGAGACACCATCGAGGAGCACAGGCAGTTTGGGGGCAACTGTGATGTGGACGTGTCTTTC
ATGTACCTGACCTTCTTCCTCGAGGACGACGACAAGCTCGAGCAGATCAGGAAGGATTAC
ACCAGCGGAGCCATGCTCACCGGTGAGCTCAAGAAGGCACTCATAGAGGTTCTGCAGCCC
TTGATCGCAGAGCACCAGGCCCGGCGCAAGGAGGTCACGGATGAGATAGTGAAAGAGTTC
ATGACTCCCCGGAAGCTGTCCTTCGACTTTCAGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M77804

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_20_Locus:
14q32.31

# Metabolic_Enzyme_20_SNPs:
rs9453; rs2234529; rs941928; rs8012938; rs8022027; rs2400898; rs2400899; rs941927; rs4905956; rs941929; rs941930; rs941931; rs3994912; rs6575775; rs3783346; rs10149239; rs2301240; rs3783347; rs12888855; rs7150701; rs4905957; rs10149438; rs1887198; rs10438233; rs11622361; rs941923; rs1009812; rs9324020; rs2146106; rs2146107; rs7154151; rs11160582; rs10438234; rs2234532; rs10438232; rs1373; rs10142340; rs4905953; rs2234528; rs4905954; rs1570305; rs1983770; rs4900463; rs7144866; rs10141823; rs732625; rs11624738; rs9671761; rs7156157; rs8009897; rs8009435; rs10141847; rs11620717; rs8010851; rs10873516; rs12882639; rs4905952; rs8008560; rs11626703; rs11624974; rs2234523; rs8009578; rs8009443; rs7155068; rs11626882; rs2234530; rs4905951; rs2234533; rs10142580; rs7154999; rs2234525; rs10141925; rs732626; rs11627197; rs11629422; rs7157522; rs3783345; rs2234524; rs11629457; rs11623879; rs8022658; rs8009765; rs11160581; rs3742384; rs8012062; rs6575773; rs3742383; rs12887559; rs2234520; rs2234521; rs2234522; rs11541753; rs1803791; rs11541754; rs3825556; rs34312584; rs34511223; rs2247044; rs34255137; rs34903259; rs2400915; rs12887392; rs2400906; rs2400916; rs1051002; rs1051043; rs12888583; rs2400905; rs34428908; rs2400904; rs6575774; rs13885; rs3838956; rs2400913; rs1131344; rs35551916; rs33915530; rs8018305; rs2246904; rs2400914; rs7906; rs1131345; rs2400902; rs2400911; rs2400918; rs2400909; rs5810994; rs1051022; rs11271487; rs2478493; rs3809407; rs8021207; rs1051051; rs2400917; rs2400912; rs10612736; rs2400903; rs2478492; rs35916618; rs2246905; rs34107388; rs35100722; rs2400907; rs2400900; rs2400910; rs34966278; rs2400908; rs2400901; rs34345611; rs12887608; rs34304748; rs3783341; rs35102588; rs12896648; rs34231621; rs11279498; rs28633946; rs12882218; rs28651775; rs11626328; rs35384251; rs35863763; rs12880435; rs2234526; rs12892068; rs3842315; rs12880834; rs3783342; rs10636945; rs34070753; rs12896107; rs5810992; rs8004957; rs34657918; rs28708874; rs35136309; rs10593205; rs12888911; rs34115089; rs35387609; rs2234531; rs11383055; rs8020597; rs4520782; rs36210845; rs8004757; rs35594168; rs12880110; rs34489833; rs11160583; rs11624811; rs12882363; rs2281893; rs12880803; rs7142222; rs35725702; rs33934327; rs7141631; rs8020087; rs2400879; rs9707505; rs12880761; rs33939310; rs3783343; rs2234527; rs4900461; rs12892489; rs34040257; rs10148928; rs10619515; rs35202616; rs12881475; rs12887585; rs11276770; rs3783344; rs34113960; rs35520638; rs33952550; rs11394611; rs34924236; rs35032026; rs34256537; rs10144242; rs10147903; rs11160584; rs11622502; rs12882934; rs12897338; rs12897688; rs17554326; rs1951519; rs1957453; rs2146104; rs2146105; rs2181170; rs2234517; rs2234518; rs2234519; rs2273800; rs2273801; rs2273802; rs2273803; rs2273804; rs2475486; rs3117689; rs34007610; rs34184867; rs34205276; rs34277171; rs34331240; rs35007880; rs35097172; rs35966201; rs36056565; rs3736951; rs3736952; rs3742380; rs3742381; rs3742382; rs3742387; rs3764786; rs4905950; rs7143025; rs7147511; rs7155877; rs724392; rs732898; rs8007184; rs8015259; rs9324019; rs941926; rs9972137

# Metabolic_Enzyme_20_General_References:
1761529; 1763065; 1765274; 1537332; 8724762; 7685728; 1286667; 1373391

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5847

# Metabolic_Enzyme_21_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

# Metabolic_Enzyme_21_Synonyms:
Not Available

# Metabolic_Enzyme_21_Gene_Name:
PDE8A

# Metabolic_Enzyme_21_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
AMGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGS
GKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLAC
FLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAG
FTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQY
ANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDN
IQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGS
LDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVL
EILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPI
SLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLR
SWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVD
HPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQ
GIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKR
MLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQI
SFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE

# Metabolic_Enzyme_21_Number_of_Residues:
829

# Metabolic_Enzyme_21_Molecular_Weight:
93305

# Metabolic_Enzyme_21_Theoretical_pI:
6.03

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  protein kinase activity
Function:  protein histidine kinase activity
Function:  two-component sensor molecule activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_21_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development

# Metabolic_Enzyme_21_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_21_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_21_Signals:
None

# Metabolic_Enzyme_21_Transmembrane_Regions:
None

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_21_GenBank_ID_Protein:
16417190

# Metabolic_Enzyme_21_SwissProt_ID:
PDE8A_HUMAN (O60658)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
PDE8A

# Metabolic_Enzyme_21_Geneatlas_id:
PDE8A

# Metabolic_Enzyme_21_hgnc_id:
HGNC:8793

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_21_Gene_Sequence:
>2490 bp
ATGGGCTGTGCCCCGAGCATCCACATTTCCGAGCGCCTGGTGGCCGAGGACGCGCCTAGC
CCCGCGGCACCGCCGCTGTCGTCCGGCGGGCCGCGCCTCCCGCAGGGCCAGAAGACGGCC
GCCTTGCCCCGGACCCGCGGCGCCGGCCTCTTGGAGTCGGAGCTTCGCGACGGCAGCGGC
AAGAAGGTAGCAGTAGCTGATGTGCAGTTTGGCCCCATGAGATTTCATCAAGATCAACTT
CAGGTACTTTTAGTGTTTACCAAAGAAGATAACCAATGTAATGGATTCTGCAGGGCATGT
GAAAAAGCAGGGTTTAAGTGTACAGTTACCAAGGAGGCTCAGGCTGTCCTTGCCTGTTTC
CTGGACAAACATCATGACATTATCATCATAGACCACAGAAATCCTCGACAGCTGGATGCA
GAGGCACTGTGCAGGTCTATCAGATCATCAAAACTCTCAGAAAACACAGTTATTGTTGGT
GTAGTACGCAGGGTGGATAGAGAAGAGTTGTCCGTAATGCCTTTCATTTCTGCTGGATTT
ACAAGGAGGTATGTAGAAAACCCCAACATCATGGCCTGCTACAATGAACTGCTCCAGCTG
GAGTTTGGAGAGGTGCGATCACAACTGAAACTCAGGGCTTGTAACTCAGTATTCACTGCA
TTAGAAAACAGTGAAGATGCAATTGAAATTACAAGCGAAGACCGTTTTATACAGTATGCA
AATCCTGCATTTGAAACAACAATGGGCTATCAGTCAGGTGAATTAATAGGGAAGGAGTTA
GGAGAAGTGCCTATAAATGAAAAAAAGGCTGACTTGCTCGATACTATAAATTCATGCATC
AGGATAGGCAAGGAGTGGCAAGGAATTTACTATGCAAAAAAGAAAAACGGAGATAATATA
CAACAAAATGTGAAGATAATACCTGTCATTGGACAGGGAGGAAAAATTAGACACTATGTG
TCCATTATCAGAGTGTGCAATGGCAACAATAAGGCTGAGAAAATATCCGAATGTGTTCAG
TCTGACACTCATACAGATAATCAGACAGGCAAACATAAAGACAGGAGAAAAGGCTCACTA
GACGTCAAAGCTGTTGCCTCCCGTGCAACTGAAGTTTCCAGCCAGAGACGACACTCTTCC
ATGGCCCGGATACATTCCATGACAATTGAGGCGCCCATCACCAAGGTAATCAATATTATC
AATGCTGCCCAGGAAAGTAGTCCCATGCCTGTGACAGAAGCCCTAGACCGTGTGCTGGAA
ATTCTAAGAACCACTGAGTTATATTCACCACAGTTTGGTGCTAAAGATGATGATCCCCAT
GCCAATGACCTTGTTGGGGGCTTAATGTCTGATGGTTTGCGAAGACTATCAGGGAATGAA
TATGTTCTTTCAACAAAAAACACTCAAATGGTTTCAAGCAATATAATCACTCCCATCTCC
CTTGATGATGTCCCACCACGGATAGCTCGGGCCATGGAAAATGAGGAATACTGGGACTTT
GATATTTTTGAACTGGAGGCTGCCACCCACAATAGGCCTTTGATTTATCTTGGTCTCAAA
ATGTTTGCTCGCTTTGGAATCTGTGAATTCTTACACTGCTCCGAGTCAACGCTAAGATCA
TGGTTACAAATTATCGAAGCCAATTATCATTCCTCCAATCCCTACCACAATTCTACACAT
TCTGCTGATGTGCTTCATGCCACTGCCTATTTTCTCTCCAAGGAGAGGATAAAGGAAACT
TTAGATCCAATTGATGAGGTCGCTGCACTCATCGCAGCCACCATTCATGATGTGGATCAC
CCTGGGAGAACCAACTCCTTCCTGTGTAATGCTGGAAGTGAGCTGGCCATTTTGTACAAT
GACACTGCTGTGCTGGAGAGCCACCATGCGGCCTTGGCCTTCCAGCTGACCACTGGAGAT
GATAAATGCAATATATTTAAAAACATGGAGAGGAATGATTATCGGACACTGCGCCAGGGG
ATTATCGACATGGTCTTAGCCACAGAAATGACAAAGCACTTTGAGCATGTCAACAAATTT
GTCAACAGCATCAACAAACCCTTGGCAACACTAGAAGAAAATGGGGAAACTGATAAAAAC
CAGGAAGTGATAAACACTATGCTTAGGACTCCAGAGAACCGGACCCTAATCAAACGAATG
CTGATTAAATGTGCTGATGTGTCCAATCCCTGCCGACCCCTGCAGTACTGCATCGAGTGG
GCTGCACGCATTTCGGAAGAATATTTTTCTCAGACTGATGAAGAGAAGCAGCAGGGCTTA
CCTGTGGTGATGCCAGTGTTTGACAGAAATACCTGCAGCATCCCCAAATCCCAAATCTCT
TTCATTGATTACTTCATCACAGACATGTTTGATGCTTGGGATGCCTTTGTAGACCTGCCT
GATTTAATGCAGCATCTTGACAACAACTTTAAATACTGGAAAGGACTGGACGAAATGAAG
CTGCGGAACCTCCGACCACCTCCTGAATAG

# Metabolic_Enzyme_21_GenBank_ID_Gene:
AF388183

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_21_Locus:
15q25.3

# Metabolic_Enzyme_21_SNPs:
rs16974908; rs289392; rs2304422; rs289412; rs289389; rs734495; rs1973516; rs1014543; rs289374; rs289417; rs2342974; rs1868921; rs930716; rs289400; rs289390; rs12904386; rs289383; rs289393; rs12904890; rs12437935; rs289414; rs289411; rs6496586; rs3816106; rs289405; rs7402176; rs2290273; rs289387; rs7402932; rs289410; rs8026543; rs379799; rs12903975; rs4843019; rs289386; rs3816104; rs11073916; rs3816103; rs289418; rs11856330; rs2304416; rs4842864; rs7174722; rs2304417; rs11073917; rs8032301; rs289399; rs7182533; rs971804; rs185972; rs418676; rs11073939; rs8038149; rs2304420; rs7402770; rs9920027; rs2304419; rs409211; rs7403474; rs2122858; rs289416; rs7163965; rs208966; rs7175477; rs2304418; rs744422; rs10852130; rs12440719; rs11631548; rs12912134; rs190840; rs11632658; rs12232314; rs12102045; rs10520586; rs289419; rs11854452; rs2923731; rs1011436; rs2015233; rs2304421; rs289381; rs289388; rs12904238; rs7182328; rs289401; rs12438909; rs17540307; rs2938354; rs3816105; rs289380; rs289406; rs12902942; rs17611396; rs4842865; rs16974823; rs17541051; rs1011437; rs289402; rs17610201; rs289396; rs289375; rs11631171; rs2304415; rs289403; rs1969101; rs17611171; rs17612860; rs11856097; rs8032954; rs12441196; rs7174762; rs11632899; rs1023844; rs16974676; rs16974785; rs12592539; rs16974197; rs12910668; rs2174218; rs12909971; rs7402179; rs289404; rs12913859; rs4843014; rs289391; rs380185; rs289373; rs289413; rs289409; rs289379; rs4842863; rs16974804; rs12910060; rs4843015; rs11634975; rs11858363; rs12905036; rs12904615; rs16974868; rs12903145; rs289378; rs289407; rs16974819; rs7182132; rs4980356; rs17841204; rs16974764; rs16974757; rs8039136; rs17611290; rs7170598; rs12909111; rs12900736; rs12438541; rs377369; rs16974726; rs395573; rs11634877; rs12900012; rs9302348; rs16974846; rs13380056; rs7359256; rs12904766; rs11637237; rs4980340; rs289376; rs289382; rs17610265; rs4842866; rs16974870; rs11632175; rs11856381; rs12899693; rs7403468; rs16974769; rs12904410; rs12906544; rs289420; rs35000527; rs12908535; rs12908400; rs11629962; rs17611075; rs167036; rs1532776; rs8029977; rs12912860; rs12911330; rs8039116; rs10083650; rs2599365; rs4843018; rs16974820; rs8028550; rs12908252; rs2599364; rs188296; rs8040352; rs7402299; rs11852878; rs8025202; rs12916129; rs16974844; rs16974793; rs16974867; rs8029936; rs289415; rs7178852; rs9796658; rs11629963; rs289397; rs8035204; rs16974732; rs7178157; rs17540501; rs16974775; rs12440263; rs12324252; rs16974842; rs16974673; rs12909130; rs439307; rs289398; rs8023667; rs8041380; rs11073905; rs11637512; rs4296226; rs7403597; rs11629967; rs3850985; rs11854185; rs16974759; rs439313; rs16974194; rs12591070; rs10852131; rs11073915; rs12439284; rs16974777; rs11630697; rs7183199; rs16974791; rs16974827; rs11631184; rs11073955; rs6496733; rs994989; rs11073962; rs8041624; rs7167692; rs11073952; rs4843020; rs4842868; rs16974899; rs13379959; rs12592211; rs1606119; rs7171410; rs907260; rs3743157; rs6496728; rs3862411; rs17541572; rs10520585; rs11852268; rs11073951; rs12899508; rs7177110; rs16974896; rs16974907; rs12324715; rs10152707; rs16974898; rs12594377; rs16974913; rs4842867; rs12324638; rs12904058; rs11633076; rs12914674; rs12324243; rs12148170; rs16974889; rs11638610; rs2063441; rs11540803; rs17855018; rs35666574; rs35134026; rs28517708; rs34477344; rs289377; rs34139398; rs3835084; rs12905238; rs36160047; rs11633746; rs35038078; rs35476219; rs34096140; rs28583919; rs36146722; rs16974849; rs28599738; rs11447909; rs34187163; rs35529308; rs10683452; rs34026921; rs10686479; rs28393234; rs12912097; rs3042715; rs35843593; rs35816571; rs7496602; rs35835700; rs34212320; rs34978449; rs10596049; rs12593868; rs12903901; rs5814181; rs35668291; rs4980341; rs35902872; rs34345801; rs35287208; rs12443441; rs36226498; rs182326; rs28432948; rs4038084; rs35024665; rs28626509; rs28674753; rs4038603; rs10714340; rs35613655; rs12899359; rs16974740; rs12899190; rs9920206; rs12904958; rs34715649; rs12916821; rs28703945; rs34741081; rs12908865; rs16974874; rs7163704; rs2654915; rs3077007; rs16974881; rs34743976; rs13379950; rs35119272; rs28481453; rs10551825; rs28871662; rs35955528; rs16974781; rs35060961; rs35991556; rs35159041; rs34039117; rs28522595; rs35051517; rs34571125; rs12595013; rs34431228; rs28422178; rs35472864; rs2599366; rs35885781; rs34623053; rs13379744; rs289394; rs35224089; rs10583862; rs12910192; rs11279216; rs9920260; rs35985534; rs28460774; rs34072250; rs12910966; rs11300943; rs2134701; rs12915883; rs28821898; rs16974754; rs28718705; rs8040568; rs35204319; rs35155549; rs16974851; rs3947198; rs34868660; rs12911951; rs35362357; rs11408402; rs12905230; rs8031544; rs35835007; rs35886421; rs12593499; rs289395; rs16974834; rs5814184; rs35127646; rs34005057; rs7181707; rs35924887; rs11302685; rs12913418; rs34900320; rs11315378; rs12911275; rs11335223; rs34941017; rs36184157; rs28624247; rs12324120; rs34578731; rs35013304; rs35704021; rs34919315; rs35100589; rs28451934; rs12910937; rs28515053; rs35850143; rs35495694; rs35661908; rs34450665; rs28887294; rs35165347; rs3029849; rs3076299; rs12912264; rs28660426; rs36210492; rs1466166; rs28408242; rs4843016; rs3042743; rs188295; rs35845738; rs35782842; rs16974722; rs28401313; rs35332444; rs8033951; rs28635537; rs289408; rs4461049; rs34347191; rs3752716; rs7167955; rs34224590; rs28380121; rs2134700; rs28836780; rs34928221; rs11444714; rs13379486; rs289385; rs28567794; rs12913075; rs34585903; rs35932936; rs13380094; rs28435132; rs5814182; rs35818984; rs28438405; rs3042699; rs34054841; rs7496012; rs3042742; rs4843017; rs34703175; rs34493704; rs185973; rs5814185; rs11300141; rs28406814; rs11439217; rs16974713; rs33996207; rs34731527; rs34127115; rs28369034; rs28765192; rs34366010; rs12909357; rs28669942; rs35249102; rs35710429; rs12913985; rs10656480; rs28614128; rs3947199; rs28767827; rs34363361; rs3076297; rs5814183; rs16974847; rs289384; rs35525107; rs11286200; rs28584329; rs28878517; rs35570249; rs34684329; rs34469124; rs35150470; rs35148427; rs34262848; rs2060785; rs35187382; rs11362736; rs905600; rs28523473; rs12906040; rs11308498; rs12904056; rs34105012; rs2015030; rs4843013; rs11438322; rs35349728; rs34790691; rs2005228; rs28715864; rs8032061; rs28483160; rs35094470; rs6496597; rs34376876; rs35007697; rs34486009; rs16974680; rs28599761; rs35166229; rs10525874; rs34787669; rs34946321; rs12914463; rs34343213; rs35264353; rs3214641; rs35094035; rs35490949; rs2060784; rs35548176; rs4980357; rs12917019; rs28540038; rs35668265; rs28679569; rs3743158; rs10152517; rs6145662; rs35865189; rs34076898; rs28762802; rs35054546; rs16974903; rs1272789; rs16974914; rs34339351; rs35533990; rs35045545; rs28463717; rs1260127; rs28445014; rs12324052; rs34889576; rs35457936; rs34655030; rs16974894; rs8032913; rs34002838; rs35114584; rs36097427; rs34969758; rs1109065; rs1109066; rs11635139; rs12439802; rs12899275; rs12900078; rs35966827; rs7175160; rs7177863; rs7178415; rs8035516; rs8037886; rs896364

# Metabolic_Enzyme_21_General_References:
11738832; 9618252

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5848

# Metabolic_Enzyme_22_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

# Metabolic_Enzyme_22_Synonyms:
Cam-PDE 1B; 63 kDa Cam-PDE

# Metabolic_Enzyme_22_Gene_Name:
PDE1B

# Metabolic_Enzyme_22_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
BMELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKN
LEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEK
PKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHA
LRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFL
LRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISS
VFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKP
KALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQ
SQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVV
SFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

# Metabolic_Enzyme_22_Number_of_Residues:
536

# Metabolic_Enzyme_22_Molecular_Weight:
61380

# Metabolic_Enzyme_22_Theoretical_pI:
5.22

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Not Available

# Metabolic_Enzyme_22_Specific_Function:
Has a preference for cGMP as a substrate

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_22_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1621592

# Metabolic_Enzyme_22_SwissProt_ID:
PDE1B_HUMAN (Q01064)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
PDE1B

# Metabolic_Enzyme_22_Geneatlas_id:
PDE1B

# Metabolic_Enzyme_22_hgnc_id:
HGNC:8775

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>1611 bp
ATGGAGCTGTCCCCCCGCAGTCCTCCGGAGATGCTGGAGGAGTCGGATTGCCCGTCACCC
CTGGAGCTGAAGTCAGCCCCCAGCAAGAAGATGTGGATTAAGCTTCGGTCTCTGCTGCGC
TACATGGTGAAGCAGTTGGAGAATGGGGAGATAAACATTGAGGAGCTGAAGAAAAATCTG
GAGTACACAGCTTCTCTGCTGGAAGCCGTCTACATAGATGAGACACGGCAAATCTTGGAC
ACGGAGGACGAGCTGCAGGAGCTGCGGTCAGATGCCGTGCCTTCGGAGGTGCGGGACTGG
CTGGCCTCCACCTTCACCCAGCAGGCCCGGGCCAAAGGCCGCCGAGCAGAGGAGAAGCCC
AAGTTCCGAAGCATTGTGCACGCTGTGCAGGCTGGGATCTTCGTGGAACGGATGTTCCGG
AGAACATACACCTCTGTGGGCCCCACTTACTCTACTGCGGTTCTCAACTGTCTCAAGAAC
CTGGATCTCTGGTGCTTTGATGTCTTTTCCTTGAACCAGGCAGCAGATGACCATGCCCTG
AGGACCATTGTTTTTGAGTTGCTGACTCGGCATAACCTCATCAGCCGCTTCAAGATTCCC
ACTGTGTTTTTGATGAGTTTCCTGGATGCCTTGGAGACAGGCTATGGGAAGTACAAGAAT
CCTTACCACAACCAGATCCACGCAGCCGATGTTACCCAGACAGTCCATTGCTTCTTGCTC
CGCACAGGGATGGTGCACTGCCTGTCGGAGATTGAGCTCCTGGCCATCATCTTTGCTGCA
GCTATCCATGATTATGAGCACACGGGCACTACCAACAGCTTCCACATCCAGACCAAGTCA
GAATGTGCCATCGTGTACAATGATCGTTCAGTGCTGGAGAATCACCACATCAGCTCTGTT
TTCCGATTGATGCAGGATGATGAGATGAACATTTTCATCAACCTCACCAAGGATGAGTTT
GTAGAACTCCGAGCCCTGGTCATTGAGATGGTGTTGGCCACAGACATGTCCTGCCATTTC
CAGCAAGTGAAGACCATGAAGACAGCCTTGCAACAGCTGGAGAGGATTGACAAGCCCAAG
GCCCTGTCTCTACTGCTCCATGCTGCTGACATCAGCCACCCAACCAAGCAGTGGTTGGTC
CACAGCCGTTGGACCAAGGCCCTCATGGAGGAATTCTTCCGTCAGGGTGACAAGGAGGCA
GAGTTGGGCCTGCCCTTTTCTCCACTCTGTGACCGCACTTCCACTCTAGTGGCACAGTCT
CAGATAGGGTTCATCGACTTCATTGTGGAGCCCACATTCTCTGTGCTGACTGACGTGGCA
GAGAAGAGTGTTCAGCCCCTGGCGGATGAGGACTCCAAGTCTAAAAACCAGCCCAGCTTT
CAGTGGCGCCAGCCCTCTCTGGATGTGGAAGTGGGAGACCCCAACCCTGATGTGGTCAGC
TTTCGTTCCACCTGGGTCAAGCGCATTCAGGAGAACAAGCAGAAATGGAAGGAACGGGCA
GCAAGTGGCATCACCAACCAGATGTCCATTGACGAGCTGTCCCCCTGTGAAGAAGAGGCC
CCCCCATCCCCTGCCGAAGATGAACACAACCAGAATGGGAATCTGGATTAG

# Metabolic_Enzyme_22_GenBank_ID_Gene:
U56976

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_22_Locus:
12q13

# Metabolic_Enzyme_22_SNPs:
rs1249950; rs884510; rs1249951; rs1022232; rs3782403; rs1976823; rs1153138; rs11170969; rs1874308; rs7954532; rs7308435; rs1874309; rs3782404; rs1153137; rs1249949; rs4759090; rs3782411; rs11170973; rs11170974; rs2280426; rs3782410; rs11170976; rs10747699; rs1874305; rs1619029; rs1874307; rs1826728; rs1795814; rs3782405; rs10876566; rs1826729; rs7300897; rs12315671; rs4759091; rs1153136; rs1144995; rs7297522; rs9668037; rs7953703; rs10161382; rs4759092; rs12580297; rs12423459; rs3782409; rs3741670; rs7134688; rs3741671; rs7980139; rs11615709; rs12811737; rs12811532; rs12812036; rs2887906; rs35108378; rs11170978; rs34320482; rs5798310; rs2669404; rs4016630; rs35584396; rs11384809; rs1716335; rs12817930; rs35953387; rs35083639; rs34945831; rs4016629; rs1249684; rs10574598; rs36106145; rs2669406; rs34139185; rs2643610; rs34082972; rs5798309; rs1153139; rs11170971; rs34681049; rs1874306; rs34490177; rs5798308; rs34981158; rs3953265; rs4016627; rs35412225; rs10537588; rs3036634; rs34955742; rs1552957; rs1623252; rs35999388; rs12817736; rs11170972; rs12811907; rs3953266; rs3953264; rs4016628; rs3825194; rs35888172; rs35726390; rs3782407; rs10747698; rs12315672; rs35023953; rs1795817; rs3782408; rs35120300; rs1249948; rs34237967; rs3837464; rs35818150; rs35203189; rs7960002; rs35068189; rs34815974; rs35136005; rs12814787; rs12297247; rs3832832; rs11616154; rs10783631; rs10876567; rs11170968; rs11170979; rs11170980; rs11170981; rs1143960; rs1144996; rs1144997; rs1144998; rs1144999; rs1145000; rs1153140; rs1153141; rs11836274; rs1249499; rs1249682; rs1249683; rs1512905; rs1533235; rs1707483; rs2271981; rs2271982; rs2292490; rs2370971; rs3209081; rs34071274; rs34376731; rs35146181; rs3817412; rs3825195; rs7297136; rs7971175; rs8407

# Metabolic_Enzyme_22_General_References:
8855339; 9419816; 1326532

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5849

# Metabolic_Enzyme_23_Name:
Long-chain-fatty-acid--CoA ligase 1

# Metabolic_Enzyme_23_Synonyms:
Long-chain acyl-CoA synthetase 1; LACS 1; Palmitoyl-CoA ligase 1; Long-chain fatty acid CoA ligase 2; Long-chain acyl-CoA synthetase 2; LACS 2; Acyl-CoA synthetase 1; ACS1; Palmitoyl-CoA ligase 2

# Metabolic_Enzyme_23_Gene_Name:
ACSL1

# Metabolic_Enzyme_23_Protein_Sequence:
>LongchainfattyacidCoA ligase 1
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQ
SVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEW
LSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDT
LGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQR
CGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAF
VKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQP
TVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKV
QSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHV
GAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGD
IGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAI
VVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHP
ELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV

# Metabolic_Enzyme_23_Number_of_Residues:
698

# Metabolic_Enzyme_23_Molecular_Weight:
77944

# Metabolic_Enzyme_23_Theoretical_pI:
7.16

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate

# Metabolic_Enzyme_23_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_23_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
25-45

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_23_GenBank_ID_Protein:
219900

# Metabolic_Enzyme_23_SwissProt_ID:
ACSL1_HUMAN (P33121)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
ACSL1

# Metabolic_Enzyme_23_Geneatlas_id:
ACSL1

# Metabolic_Enzyme_23_hgnc_id:
HGNC:3569

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_23_Gene_Sequence:
>2097 bp
ATGCAAGCCCATGAGCTGTTCCGGTATTTTCGAATGCCAGAGCTGGTTGACTTCCGACAG
TACGTGCGTACTCTTCCGACCAACACGCTTATGGGCTTCGGAGCTTTTGCAGCACTCACC
ACCTTCTGGTACGCCACGAGACCCAAACCCCTGAAGCCGCCATGCGACCTCTCCATGCAG
TCAGTGGAAGTGGCGGGTAGTGGTGGTGCACGAAGATCCGCACTACTTGACAGCGACGAG
CCCTTGGTGTATTTCTATGATGATGTCACAACATTATACGAAGGTTTCCAGAGGGGAATA
CAGGTGTCAAATAATGGCCCTTGTTTAGGCTCTCGGAAACCAGACCAACCCTATGAATGG
CTTTCATATAAACAGGTTGCAGAATTGTCGGAGTGCATAGGCTCAGCACTGATCCAGAAG
GGCTTCAAGACTGCCCCAGATCAGTTCATTGGCATCTTTGCTCAAAATAGACCTGAGTGG
GTGATTATTGAACAAGGATGCTTTGCTTATTCGATGGTGATCGTTCCACTTTATGATACC
CTTGGAAATGAAGCCATCACGTACATAGTCAACAAAGCTGAACTCTCTCTGGTTTTTGTT
GACAAGCCAGAGAAGGCCAAACTCTTATTAGAGGGTGTAGAAAATAAGTTAATACCAGGC
CTTAAAATCATAGTTGTCATGGATGCCTACGGCAGTGAACTGGTGGAACGAGGCCAGAGG
TGTGGGGTGGAAGTCACCAGCATGAAGGCGATGGAGGACCTGGGAAGAGCCAACAGACGG
AAGCCCAAGCCTCCAGCACCTGAAGATCTTGCAGTAATTTGTTTCACAAGTGGAACTACA
GGCAACCCCAAAGGAGCAATGGTCACTCACCGAAACATAGTGAGCGATTGTTCAGCTTTT
GTGAAAGCAACAGAGAATACAGTCAATCCTTGCCCAGATGATACTTTGATATCTTTCTTG
CCTCTCGCCCATATGTTTGAGAGAGTTGTAGAGTGTGTAATGCTGTGTCATGGAGCTAAA
ATCGGATTTTTCCAAGGAGATATCAGGCTGCTCATGGATGACCTCAAGGTGCTTCAACCC
ACTGTCTTCCCCGTGGTTCCAAGACTGCTGAACCGGATGTTTGACCGAATTTTCGGACAA
GCAAACACCACGCTGAAGCGATGGCTCTTGGACTTTGCCTCCAAGAGGAAAGAAGCAGAG
CTTCGCAGCGGCATCATCAGAAACAACAGCCTGTGGGACCGGCTGATCTTCCACAAAGTA
CAGTCGAGCCTGGGCGGAAGAGTCCGGCTGATGGTGACAGGAGCCGCCCCGGTGTCTGCC
ACTGTGCTGACGTTCCTCAGAGCAGCCCTGGGCTGTCAGTTTTATGAAGGATACGGACAG
ACAGAGTGCACTGCCGGGTGCTGCCTAACCATGCCTGGAGACTGGACCGCAGGCCATGTT
GGGGCCCCGATGCCGTGCAATTTGATAAAACTTGTTGATGTGGAAGAAATGAATTACATG
GCTGCCGAGGGCGAGGGCGAGGTGTGTGTGAAAGGGCCAAATGTATTTCAGGGCTACTTG
AAGGACCCAGCGAAAACAGCAGAAGCTTTGGACAAAGACGGCTGGTTACACACAGGGGAC
ATTGGAAAATGGTTACCAAATGGCACCTTGAAAATTATCGACCGGAAAAAGCACATATTT
AAGCTGGCACAAGGAGAATACATAGCCCCTGAAAAGATTGAAAATATCTACATGCGAAGT
GAGCCTGTTGCTCAGGTGTTTGTCCACGGAGAAAGCCTGCAGGCATTTCTCATTGCAATT
GTGGTACCAGATGTTGAGACATTATGTTCCTGGGCCCAAAAGAGAGGATTTGAAGGGTCG
TTTGAGGAACTGTGCAGAAATAAGGATGTCAAAAAAGCTATCCTCGAAGATATGGTGAGA
CTTGGGAAGGATTCTGGTCTGAAACCATTTGAACAGGTCAAAGGCATCACATTGCACCCT
GAATTATTTTCTATCGACAATGGCCTTCTGACTCCAACAATGAAGGCGAAAAGGCCAGAG
CTGCGGAACTATTTCAGGTCGCAGATAGATGACCTCTATTCCACTATCAAGGTTTAG

# Metabolic_Enzyme_23_GenBank_ID_Gene:
D10040

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_23_Locus:
4q34-q35

# Metabolic_Enzyme_23_SNPs:
rs1803898; rs11727009; rs2292898; rs34107464; rs8086; rs2292899; rs9997745; rs902177; rs10471180; rs12503643; rs13120078; rs6552828; rs7657313; rs4862424; rs1056896; rs7437957; rs1554336; rs2139178; rs6832247; rs10471181; rs6853210; rs13126272; rs11726327; rs3806795; rs4862425; rs11932648; rs6858297; rs6855716; rs12499544; rs2280297; rs13112568; rs6858762; rs12504478; rs11724755; rs7676928; rs4862413; rs4862423; rs4862412; rs28372689; rs12639729; rs745805; rs7683514; rs4069938; rs11931086; rs7681334; rs7691972; rs6816777; rs1996546; rs3792311; rs4862417; rs7660927; rs3749233; rs4861631; rs2102862; rs4862415; rs7659090; rs7695270; rs4260575; rs4862416; rs11132255; rs12504996; rs1809661; rs6856120; rs1873227; rs12504993; rs4862419; rs3792312; rs12500973; rs4861632; rs11933776; rs3749232; rs7659849; rs735949; rs7680850; rs6552822; rs2046814; rs7695530; rs10024294; rs10022018; rs7674704; rs4862414; rs7654302; rs7673894; rs7679499; rs3762647; rs12508858; rs7669535; rs10022124; rs3792316; rs7680011; rs10034312; rs7679890; rs7658194; rs6835270; rs7657787; rs7680088; rs7660128; rs12500940; rs4862418; rs12374289; rs7674420; rs11942616; rs7656414; rs12650102; rs3792313; rs7654285; rs4862420; rs7661585; rs10155154; rs7653899; rs1532126; rs12648552; rs13105565; rs11724266; rs1873226; rs7683525; rs7678719; rs11931782; rs6552823; rs6854220; rs4862421; rs1968957; rs6833829; rs6856693; rs6857027; rs10034931; rs12644905; rs9686055; rs1809663; rs35300241; rs41278585; rs11550466; rs7691497; rs34405073; rs10010777; rs11132256; rs28728235; rs35762679; rs10538881; rs28701695; rs13114314; rs13148384; rs35019674; rs10471182; rs11940804; rs3208919; rs34348426; rs35492164; rs6831456; rs10003568; rs28562837; rs9884883; rs1212632; rs10011975; rs11430387; rs13124672; rs6845030; rs35340636; rs34859453; rs13148929; rs1803899; rs7668458; rs6845017; rs34777946; rs9993625; rs34202162; rs12510622; rs28535270; rs36106681; rs35357283; rs13149718; rs10009339; rs1803900; rs6817429; rs13126874; rs34065103; rs34391801; rs939040; rs902172; rs5864900; rs41278587; rs11309893; rs35591478; rs28454355; rs34632049; rs35626120; rs34359988; rs11277994; rs2139180; rs7677878; rs35061702; rs2139179; rs10571387; rs34639885; rs28641704; rs35819308; rs34735694; rs34635480; rs34197776; rs35213333; rs9331559; rs6836024; rs28505088; rs28448828; rs34416324; rs11462454; rs11356929; rs10673308; rs34185049; rs34910932; rs1212963; rs35248610; rs6823198; rs13144160; rs28595757; rs34341754; rs5864899; rs28522296; rs11389928; rs35617684; rs6852479; rs35057394; rs35677827; rs13137179; rs6825554; rs6841747; rs13137387; rs11450168; rs41278583; rs36059531; rs35983670; rs7686479; rs6855063; rs28654407; rs3792314; rs7669004; rs7679708; rs13127985; rs35397890; rs28711309; rs3792315; rs35479277; rs11321925; rs1878873; rs34103839; rs34392146; rs34772558; rs735948; rs35565140; rs10002538; rs35180310; rs879779; rs4862422; rs34311553; rs3840201; rs35698174; rs11323129; rs35994035; rs6828290; rs36077190; rs33938195; rs3840200; rs11412087; rs4577621; rs35487731; rs34084432; rs34360556; rs41278581; rs34032660; rs4861633; rs10536708; rs35746022; rs28582376; rs6857505; rs28526229; rs2020016; rs34309875; rs4861634; rs28709399; rs11325509; rs2090591; rs11457984; rs10005356; rs10018054; rs10021219; rs10021290; rs10027540; rs10033885; rs11732302; rs11934173; rs11934462; rs11935201; rs11936062; rs11938887; rs12512574; rs13127359; rs1387678; rs2171838; rs36080963; rs6552824; rs6827693; rs6854996; rs755534; rs755535; rs755536; rs7675463; rs7675780; rs7676174; rs902179

# Metabolic_Enzyme_23_General_References:
1607358; 8584017; 10548543

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5850

# Metabolic_Enzyme_24_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

# Metabolic_Enzyme_24_Synonyms:
Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B; CGIPDE1; CGIP1

# Metabolic_Enzyme_24_Gene_Name:
PDE3B

# Metabolic_Enzyme_24_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
BMRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVEL
RPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSL
SPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDG
DAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGS
LPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVS
LGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEA
RNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEK
GDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNG
PFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPD
TADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCS
GKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSL
DLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQ
FMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRI
NHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAP
QAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHF
DFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEF
YEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEED
NDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEE
EKCKADGNKLQVENSSLPQADEIQVIEEADEEE

# Metabolic_Enzyme_24_Number_of_Residues:
1112

# Metabolic_Enzyme_24_Molecular_Weight:
124335

# Metabolic_Enzyme_24_Theoretical_pI:
5.75

# Metabolic_Enzyme_24_GO_Classification:
Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
May play a role in fat metabolism

# Metabolic_Enzyme_24_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_24_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_24_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
88-108
117-137
152-172
192-212
220-240
247-267

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_24_GenBank_ID_Protein:
1145302

# Metabolic_Enzyme_24_SwissProt_ID:
PDE3B_HUMAN (Q13370)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PDE3B

# Metabolic_Enzyme_24_Geneatlas_id:
PDE3B

# Metabolic_Enzyme_24_hgnc_id:
HGNC:8779

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_24_Gene_Sequence:
>3339 bp
ATGAGGAGGGACGAGCGAGACGCCAAAGCCATGCGGTCCCTGCAGCCGCCGGATGGGGCC
GGCTCGCCCCCCGAGAGTCTGAGGAACGGCTACGTGAAGAGCTGCGTGAGCCCCTTGCGG
CAGGACCCTCCGCGCGGCTTCTTCTTCCACCTCTGCCGCTTCTGCAACGTGGAGCTGCGG
CCGCCGCCGGCCTCTCCCCAGCAGCCGCGGCGCTGCTCCCCCTTCTGCCGGGCGCGCCTC
TCGCTGGGCGACCTGGCTGCCTTTGTCCTCGCCCTGCTGCTGGGAGCGGAACCCGAGAGC
TGGGCTGCCGGGGCCGCCTGGCTGCGGACGCTGCTGAGCGTGTGTTCGCACAGCTTGAGC
CCCCTCTTCAGCATCGCCTGTGCCTTCTTCTTCCTCACCTGCTTCCTCACCCGGACCAAG
CGGGGACCCGGCCCGGGCCGGAGCTGCGGCTCCTGGTGGCTGCTGGCGCTGCCCGCCTGC
TGTTACCTGGGGGACTTCTTGGTGTGGCAGTGGTGGTCTTGGCCTTGGGGGGATGGCGAC
GCAGGGTCCGCGGCCCCGCACACGCCCCCGGAGGCGGCAGCGGGCAGGTTGCTGCTGGTG
CTGAGCTGCGTAGGGCTGCTGCTGACGCTCGCGCACCCGCTGCGGCTCCGGCACTGCGTT
CTGGTGCTGCTCCTGGCCAGCTTCGTCTGGTGGGTCTCCTTCACCAGCCTCGGGTCGCTG
CCCTCCGCCCTCAGGCCGCTGCTCTCCGGCCTGGTGGGGGGCGCTGGCTGCCTGCTGGCC
CTGGGGTTGGATCACTTCTTTCAAATCAGGGAAGCGCCTCTTCATCCTCGACTGTCCAGT
GCCGCCGAAGAAAAAGTGCCTGTGATCCGACCCCGGAGGAGGTCCAGCTGCGTGTCGTTA
GGAGAAACTGCAGCCAGTTACTATGGCAGTTGCAAAATATTCAGGAGACCGTCGTTGCCT
TGTATTTCCAGAGAACAGATGATTCTTTGGGATTGGGACTTAAAACAATGGTATAAGCCT
CATTATCAAAATTCTGGAGGTGGAAATGGAGTTGATCTTTCAGTGCTAAATGAGGCTCGC
AATATGGTGTCAGATCTTCTGACTGATCCAAGCCTTCCACCACAAGTCATTTCCTCTCTA
CGGAGTATTAGTAGCTTAATGGGTGCTTTCTCAGGTTCCTGTAGGCCAAAGATTAATCCT
CTCACACCATTTCCTGGATTTTACCCCTGTTCTGAAATAGAGGACCCAGCTGAGAAAGGG
GATAGAAAACTTAACAAGGGACTAAATAGGAATAGTTTGCCAACTCCACAGCTGAGGAGA
AGCTCAGGAACTTCAGGATTGCTACCTGTTGAACAGTCTTCAAGGTGGGATCGTAATAAT
GGCAAAAGGCCTCACCAAGAATTTGGCATTTCAAGTCAAGGATGCTATCTAAATGGGCCT
TTTAATTCAAATCTACTGACTATCCCGAAGCAAAGGTCATCTTCTGTATCACTGACTCAC
CATGTAGGTCTCAGAAGAGCTGGTGTTTTGTCCAGTCTGAGTCCTGTGAATTCTTCCAAC
CATGGACCAGTGTCTACTGGCTCTCTAACTAATCGATCACCCATAGAATTTCCTGATACT
GCTGATTTTCTTAATAAGCCAAGCGTTATCTTGCAGAGATCTCTGGGCAATGCACCTAAT
ACTCCAGATTTTTATCAGCAACTTAGAAATTCTGATAGCAATCTGTGTAACAGCTGTGGA
CATCAAATGCTGAAATATGTTTCAACATCTGAATCAGATGGTACAGATTGCTGCAGTGGA
AAATCAGGTGAAGAAGAAAACATTTTCTCGAAAGAATCATTCAAACTTATGGAAACTCAA
CAAGAAGAGGAAACAGAGAAGAAAGACAGCAGAAAATTATTTCAGGAAGGTGATAAGTGG
CTAACAGAAGAGGCACAGAGTGAACAGCAAACAAATATTGAACAGGAAGTATCACTGGAC
CTGATTTTAGTAGAAGAGTATGACTCATTAATAGAAAAGATGAGCAACTGGAATTTTCCA
ATTTTTGAACTTGTAGAAAAGATGGGAGAGAAATCAGGAAGGATTCTCAGTCAGGTTATG
TATACCTTATTTCAAGACACTGGTTTATTGGAAATATTTAAAATTCCCACTCAACAATTT
ATGAACTATTTTCGTGCATTAGAAAATGGCTATCGAGACATTCCTTATCACAATCGTATA
CATGCCACAGATGTGCTACATGCAGTTTGGTATCTGACAACACGGCCAGTTCCTGGCTTA
CAGCAGATCCACAATGGTTGTGGAACAGGAAATGAAACAGATTCTGATGGTAGAATTAAC
CATGGGCGAATTGCTTATATTTCTTCGAAGAGCTGCTCTAATCCTGATGAGAGTTATGGC
TGCCTGTCTTCAAACATTCCTGCATTAGAATTGATGGCTCTATACGTGGCAGCTGCCATG
CATGATTATGATCACCCAGGGAGGACAAATGCATTTCTAGTGGCTACAAATGCCCCTCAG
GCAGTTTTATACAATGACAGATCTGTTCTGGAAAATCATCATGCTGCGTCAGCTTGGAAT
CTATATCTTTCTCGCCCAGAATACAACTTCCTTCTTCATCTTGATCATGTGGAATTCAAG
CGCTTTCGTTTTTTAGTCATTGAAGCAATCCTTGCTACGGATCTTAAAAAGCATTTTGAT
TTTCTCGCAGAATTCAATGCCAAGGCAAATGATGTAAATAGTAATGGCATAGAATGGAGT
AATGAAAATGATCGCCTCTTGGTATGCCAGGTGTGCATCAAACTGGCAGATATAAATGGC
CCAGCAAAAGTTCGAGACTTGCATTTGAAATGGACAGAAGGCATTGTCAATGAATTTTAT
GAGCAGGGAGATGAAGAAGCAAATCTTGGTCTGCCCATCAGTCCATTCATGGATCGTTCT
TCTCCTCAACTAGCAAAACTCCAAGAATCTTTTATCACCCACATAGTGGGTCCCCTGTGT
AACTCCTATGATGCTGCTGGTTTGCTACCAGGTCAGTGGTTAGAAGCAGAAGAGGATAAT
GATACTGAAAGTGGTGATGATGAAGACGGTGAAGAATTAGATACAGAAGATGAAGAAATG
GAAAACAATCTAAATCCAAAACCACCAAGAAGGAAAAGCAGACGGCGAATATTTTGTCAG
CTAATGCACCACCTCACTGAAAACCACAAGATATGGAAGGAAATCGTAGAGGAAGAAGAA
AAATGTAAAGCTGATGGGAATAAACTGCAGGTGGAGAATTCCTCCTTACCTCAAGCAGAT
GAGATTCAGGTAATTGAAGAGGCAGATGAAGAGGAATAG

# Metabolic_Enzyme_24_GenBank_ID_Gene:
U38178

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_24_Locus:
11p15.1

# Metabolic_Enzyme_24_SNPs:
rs4757268; rs1247719; rs1247720; rs2060794; rs6486205; rs10832310; rs10832302; rs7952393; rs1403249; rs10219313; rs2177197; rs1007392; rs2167453; rs1037379; rs7942142; rs7117383; rs10766195; rs10832312; rs10832297; rs7117967; rs4144487; rs7109368; rs2350239; rs1879888; rs7947041; rs10734227; rs10732460; rs4757261; rs10832296; rs1403248; rs1879890; rs10832299; rs7102741; rs10741656; rs4757262; rs16930498; rs11023310; rs11023315; rs10128681; rs11023294; rs731042; rs4344519; rs10832309; rs7113970; rs11821089; rs11493371; rs10832306; rs7116978; rs10832294; rs7103015; rs12577507; rs10430883; rs3206554; rs1879889; rs12419818; rs7119073; rs11826363; rs9971395; rs1496167; rs7125781; rs1451677; rs1037378; rs10741653; rs1451678; rs16930448; rs11023350; rs7939648; rs12416696; rs11827089; rs10832304; rs11023322; rs1542291; rs12283049; rs11023332; rs7944633; rs10766192; rs3740823; rs7938266; rs16930437; rs6486201; rs7118016; rs2349789; rs12295371; rs7483120; rs10160291; rs7108484; rs11023333; rs7102037; rs4757266; rs12788030; rs2122942; rs12575877; rs7119320; rs11600656; rs11600815; rs10832311; rs2349790; rs10832298; rs11023298; rs10741655; rs7109892; rs6486202; rs16930520; rs994953; rs10832291; rs11023314; rs12577302; rs7101755; rs1812422; rs12226716; rs11605452; rs1839834; rs11023307; rs11023293; rs4757264; rs10832303; rs2122941; rs11023338; rs7108485; rs11023312; rs7120890; rs7937511; rs11023341; rs10832308; rs7108996; rs10832290; rs11600054; rs10832307; rs2349792; rs12577984; rs16930516; rs6486203; rs10766189; rs11023301; rs10832289; rs1996845; rs11827484; rs10832293; rs11602976; rs17409116; rs6486200; rs11607383; rs2350240; rs11828362; rs12281928; rs7114131; rs4356261; rs11023295; rs4373971; rs16930500; rs7108085; rs1597689; rs7941356; rs17487995; rs7124234; rs10734226; rs16930417; rs11822044; rs11825595; rs12419657; rs7109324; rs11023366; rs11023299; rs12275997; rs10832301; rs2349793; rs4757269; rs10741654; rs11820798; rs7941282; rs17847308; rs17847305; rs3758762; rs35435795; rs12797647; rs11023300; rs28553464; rs5789854; rs11454337; rs34804824; rs5789848; rs11333119; rs12275731; rs12788403; rs11023317; rs11355203; rs11023367; rs12281621; rs11023323; rs11023306; rs10676187; rs35362268; rs11820859; rs11023348; rs12788556; rs1011649; rs34241017; rs34596529; rs34786278; rs34303741; rs35055334; rs7103459; rs11023331; rs35327317; rs10430881; rs11828911; rs4294593; rs3059191; rs11023352; rs36116790; rs11023364; rs34059683; rs2088266; rs11023343; rs12226160; rs34954349; rs34189385; rs35321904; rs11023360; rs1357333; rs12797253; rs34662834; rs10832292; rs35712723; rs11023327; rs35949086; rs10766193; rs11821380; rs34687016; rs34466563; rs34654813; rs2060795; rs34154564; rs1451675; rs10710184; rs35606970; rs5789853; rs11606533; rs34360743; rs34041254; rs35440758; rs34572489; rs10766194; rs34555721; rs11023356; rs12787596; rs35283294; rs3834439; rs34905422; rs11023325; rs7938369; rs12795812; rs1065539; rs35596025; rs10832295; rs5789851; rs11510168; rs11309629; rs35166452; rs35021133; rs12576750; rs36115886; rs35568417; rs12270174; rs12574319; rs11023320; rs11023349; rs35024500; rs34706114; rs35887203; rs34644033; rs28825106; rs9735337; rs11602179; rs36072943; rs10047458; rs10534250; rs4757263; rs28689801; rs28523396; rs11023344; rs12360598; rs11601586; rs10666771; rs35969978; rs35595332; rs10766190; rs35637093; rs7483046; rs12362671; rs12576508; rs4367976; rs4757267; rs5789846; rs7109801; rs11023351; rs36006283; rs11023359; rs34641133; rs34945945; rs12803117; rs11023330; rs11529568; rs4492851; rs4589330; rs34954991; rs12788363; rs12797543; rs11023368; rs5010969; rs7931505; rs1996844; rs4275651; rs12290200; rs35913217; rs11023296; rs11023326; rs34552938; rs12797650; rs7928396; rs34175247; rs12808918; rs11419989; rs12281550; rs36114974; rs5789852; rs11023361; rs34924724; rs34083172; rs35572071; rs11023319; rs12785496; rs12575421; rs7925742; rs11023329; rs2204135; rs2349791; rs10590358; rs35494855; rs11023321; rs4281505; rs11600046; rs12366054; rs34569843; rs11023335; rs35823303; rs10430882; rs11408185; rs3834440; rs35648670; rs7924479; rs34862859; rs35211975; rs35820244; rs34813284; rs4575307; rs35895679; rs4356262; rs12795858; rs35700152; rs3758763; rs11023354; rs11023324; rs34139819; rs5789847; rs11023365; rs11023345; rs12795794; rs11023313; rs11023309; rs11529569; rs35730548; rs1115248; rs10626907; rs11023358; rs35212472; rs12224911; rs35104590; rs35926137; rs11023308; rs12362090; rs4283008; rs11023337; rs34129246; rs11023342; rs11023357; rs4477466; rs11023311; rs12792463; rs35291929; rs4757265; rs34509621; rs34966272; rs12417206; rs12805859; rs11023347; rs7342234; rs11820820; rs35577691; rs11023362; rs35185862; rs36069287; rs34106565; rs10555077; rs11023316; rs11023305; rs7396747; rs35012534; rs11023318; rs34974264; rs35972023; rs11023353; rs34427806; rs7127312; rs1376692; rs12418776; rs12419521; rs34365112; rs11313201; rs12364493; rs34567179; rs12362122; rs7944149; rs12801860; rs10610728; rs1451676; rs12361595; rs11023292; rs11023336; rs7945265; rs5789850; rs11023363; rs35483173; rs34959387; rs35827559; rs12788203; rs35535425; rs11604119; rs35573904; rs1349535; rs12576554; rs11023346; rs11421967; rs4281506; rs36089212; rs7105853; rs35098776; rs35938275; rs35535548; rs1056584; rs10766188; rs10832288; rs11023291; rs11023302; rs11023304; rs11023370; rs11023371; rs11600307; rs11820826; rs12417788; rs1270458; rs12796659; rs1533852; rs1868997; rs1879891; rs2291781; rs6486207; rs7104901; rs7109770

# Metabolic_Enzyme_24_General_References:
8884271; 8921398

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5606

# Metabolic_Enzyme_25_Name:
Glycogen phosphorylase, liver form

# Metabolic_Enzyme_25_Synonyms:
Not Available

# Metabolic_Enzyme_25_Gene_Name:
PYGL

# Metabolic_Enzyme_25_Protein_Sequence:
>Glycogen phosphorylase, liver form
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN

# Metabolic_Enzyme_25_Number_of_Residues:
847

# Metabolic_Enzyme_25_Molecular_Weight:
97150

# Metabolic_Enzyme_25_Theoretical_pI:
7.17

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_25_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_25_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_25_GenBank_ID_Protein:
183353

# Metabolic_Enzyme_25_SwissProt_ID:
PYGL_HUMAN (P06737)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
PYGL

# Metabolic_Enzyme_25_Geneatlas_id:
PYGL

# Metabolic_Enzyme_25_hgnc_id:
HGNC:9725

# Metabolic_Enzyme_25_PDB_ID:
1L7X

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>2544 bp
ATGGGCGAACCGCTGACAGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG
GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG
GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG
CGGGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC
AAGAGGGAATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG
ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAGCTTGGATTGGATATA
GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT
GCTGCCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT
CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAGGTAGAAGAAGCA
GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT
GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA
GTGGTCCTGGCTCTGCCATATGACACCCCCGAGCCCGGCTACATGAATAACACTGTCAAC
ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACTTTAATGTT
GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC
TATCCCAATGACAATTTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG
GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC
CGTGGTCAAGGAACTGTGTTTGATGCCTTCCCGGATCAGGTGGCCATCCAGCTGAATGAT
ACTCACCCTCGCATCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG
CCCTGGTCCAAGGCATGGGAGCTCAACCAGAAGACCTTCGCCTACACCAACCACACAGTG
CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT
TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGATAGAATTGTGGCCTTGTTTCCT
AAAGATGTGGACCCTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC
AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC
TCAGACATCGTGAAGACTAAAGTATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT
CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT
GCAGAGCTCATAGCAGAGAAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG
AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG
GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA
TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC
TGTCTGCATGTGATCACGATGTACAACCGCATTAAGAAAGACCCTAAGAAGTTATTCGTG
CCAAGGACAGTTATCATTGGTGGTAAAGCTGCCCCAGGATATCACATGGCCAAAATGATC
ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG
TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAGTCATTCCAGCC
ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG
AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG
GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGCATAGATGATGTGGCT
GCTTTGGACAAGAAAGGGTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG
CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA
GATATCATCAACATGCTATTTTATCATGACAGGTTTAAAGTCTTTGCAGACTACGAAGCC
TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATGAATCCAAAGGCCTGGAACACA
ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA
TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA
TCTAACAAAGTCAATGGAAATTGA

# Metabolic_Enzyme_25_GenBank_ID_Gene:
M14636

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_25_Locus:
14q21-q22

# Metabolic_Enzyme_25_SNPs:
rs946616; rs2228499; rs35831273; rs34313873; rs2275465; rs17123244; rs1042193; rs2027342; rs2277456; rs1959527; rs2356729; rs1890706; rs1953875; rs946618; rs946617; rs1890705; rs883699; rs1890707; rs8004768; rs10143053; rs11157783; rs2275464; rs6572712; rs7160537; rs2075646; rs6572710; rs10132049; rs3825542; rs11852047; rs3783275; rs11846565; rs8021270; rs11846180; rs8022952; rs2027341; rs1953872; rs10149867; rs11851644; rs3783273; rs3825541; rs2356535; rs3783274; rs8004788; rs11851482; rs17123189; rs11851115; rs8014291; rs2275466; rs7142143; rs12432519; rs11845307; rs7149936; rs17123178; rs1953873; rs10138493; rs10140858; rs3818871; rs8005400; rs17123235; rs11844515; rs11850411; rs3783276; rs7154048; rs8019788; rs12436081; rs12717412; rs10146041; rs8003312; rs8003460; rs882860; rs8022363; rs17123173; rs9635167; rs6572711; rs17123125; rs10142003; rs17123232; rs8005931; rs4901066; rs11845548; rs11623430; rs12878997; rs8008832; rs17123223; rs8006455; rs8019957; rs17123216; rs17123180; rs8020787; rs17123242; rs3783277; rs8019817; rs11849348; rs11851406; rs8009460; rs8019779; rs11846533; rs11850468; rs10130689; rs8020100; rs9635221; rs12887698; rs2297890; rs7159436; rs3759524; rs2297891; rs8005560; rs7159221; rs1126549; rs35026927; rs34096980; rs11541446; rs1042210; rs1042195; rs17721570; rs35110875; rs1042191; rs11356035; rs8018727; rs10539449; rs11420723; rs35650221; rs28419360; rs34660650; rs34764341; rs35154208; rs5808582; rs33962723; rs7157107; rs36014565; rs8021856; rs3837582; rs10140029; rs34040095; rs28584430; rs10146475; rs5808583; rs34267914; rs35765728; rs4540982; rs11849168; rs12888774; rs12881770; rs12882746; rs8006359; rs9788547; rs17123214; rs8009028; rs34052455; rs35565564; rs35049468; rs35657235; rs17123129; rs34648049; rs3783278; rs5808581; rs10145332; rs35116945; rs17123212; rs28497027; rs11308384; rs4027576; rs12882737; rs35955629; rs35236069; rs34707370; rs11351672; rs12887874; rs35638781; rs17123170; rs11414268; rs12881559; rs10674203; rs34456437; rs10133328; rs1890701; rs12882740; rs41317304; rs33993827; rs11846857; rs8005878; rs35069435; rs35098001; rs7141901; rs3082637; rs35620941; rs35195741; rs8016466; rs17123239; rs12882739; rs12879826; rs4898677; rs28540603; rs34592047; rs34351109; rs28407049; rs28707425; rs12880288; rs28759343; rs1005689; rs1042266; rs11157780; rs11157781; rs11157782; rs11847031; rs11847533; rs11850729; rs11850781; rs12431674; rs12431737; rs12434792; rs12589201; rs12589665; rs12880129; rs12889552; rs12891106; rs1538615; rs17123097; rs17123103; rs17123116; rs1890700; rs1890704; rs2075643; rs2075644; rs2075645; rs2185303; rs2356730; rs28564871; rs34204001; rs34240348; rs34800262; rs35501326; rs3759519; rs3759520; rs3759521; rs4901064; rs4901065; rs4901067; rs7154732; rs7159068; rs885375

# Metabolic_Enzyme_25_General_References:
2877458; 9536091; 9529348; 3509980; 10980448; 10949035; 12204691

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5851

# Metabolic_Enzyme_26_Name:
Ubiquitin-conjugating enzyme E2 G1

# Metabolic_Enzyme_26_Synonyms:
Ubiquitin-protein ligase G1; Ubiquitin carrier protein G1; E217K; UBC7

# Metabolic_Enzyme_26_Gene_Name:
UBE2G1

# Metabolic_Enzyme_26_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 G1
MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE

# Metabolic_Enzyme_26_Number_of_Residues:
170

# Metabolic_Enzyme_26_Molecular_Weight:
19509

# Metabolic_Enzyme_26_Theoretical_pI:
4.95

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Not Available

# Metabolic_Enzyme_26_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins

# Metabolic_Enzyme_26_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_26_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_26_GenBank_ID_Protein:
1741957

# Metabolic_Enzyme_26_SwissProt_ID:
UB2G1_HUMAN (P62253)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
UBE2G1

# Metabolic_Enzyme_26_Geneatlas_id:
UBE2G1

# Metabolic_Enzyme_26_hgnc_id:
HGNC:12482

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Not Available

# Metabolic_Enzyme_26_Gene_Sequence:
>513 bp
ATGACGGAGCTGCAGTCGGCACTGCTACTGCGAAGACAGCTGGCAGAACTCAACAAAAAT
CCAGTGGAAGGCTTTTCTGCAGGTTTAATAGATGACAATGATCTCTACCGATGGGAAGTC
CTTATTATTGGCCCTCCAGATACACTTTATGAAGGTGGTGTTTTTAAGGCTCATCTTACT
TTCCCAAAAGATTATCCCCTCCGACCTCCTAAAATGAAATTCATTACAGAAATCTGGCAC
CCAAATGTTGATAAAAATGGTGATGTGTGCATTTCTATTCTTCATGAGCCTGGGGAAGAT
AAGTATGGTTATGAAAAGCCAGAGGAACGCTGGCTCCCTATCCACACTGTGGAAACCATC
ATGATTAGTGTCATTTCTATGCTGGCAGACCCTAATGGAGACTCACCTGCTAATGTTGAT
GCTGCGAAAGAATGGAGGGAAGATAGAAATGGAGAATTTAAAAGAAAAGTTGCCCGCTGT
GTAAGAAAAAGCCAAGAGACTGCTTTTGAGTGA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
D78514

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_26_Locus:
1q42|17p13.2

# Metabolic_Enzyme_26_SNPs:
rs733622; rs1045738; rs11868068; rs1437808; rs11654273; rs4790603; rs2013283; rs12600975; rs9893691; rs2013273; rs11078493; rs9913489; rs28362547; rs9912854; rs9906446; rs7216966; rs16953866; rs4790604; rs12150283; rs1866176; rs2325941; rs12950048; rs2325989; rs8074770; rs7218234; rs4508454; rs8065280; rs4790605; rs4790613; rs8068219; rs11870158; rs4322703; rs2006762; rs7221915; rs8078739; rs9913013; rs6502780; rs12453940; rs6502779; rs2325987; rs2053255; rs2325988; rs7216130; rs8072251; rs934785; rs9303185; rs3966810; rs12946119; rs9894596; rs16953890; rs7212235; rs4790191; rs4456561; rs6502778; rs4467138; rs7218432; rs9889739; rs1113856; rs8066855; rs9897057; rs12600470; rs8067579; rs2325939; rs7222362; rs8078117; rs4790189; rs8078831; rs4790611; rs12937759; rs11654774; rs3902168; rs11871841; rs4790614; rs11656664; rs12709337; rs8067977; rs12600527; rs9891845; rs1113857; rs11868498; rs8068080; rs7215376; rs9915202; rs7214808; rs8067816; rs17764251; rs8073862; rs8072296; rs7224388; rs2325979; rs2006757; rs7211833; rs2325942; rs8071716; rs16953893; rs2325986; rs12944289; rs4790609; rs1866175; rs8071520; rs8064474; rs8070435; rs2304585; rs12603692; rs4790606; rs8075310; rs11078497; rs4790192; rs11078494; rs11868844; rs8079112; rs8069251; rs12452478; rs11868577; rs11078498; rs2053258; rs12937318; rs986939; rs8077918; rs9904325; rs1866174; rs8068359; rs8068360; rs8076429; rs9891357; rs17764245; rs8075852; rs8068520; rs7214726; rs8078345; rs4790190; rs8070770; rs7207791; rs12945402; rs11869527; rs893380; rs12601676; rs8065534; rs9890023; rs8064596; rs9989459; rs9989438; rs8065822; rs4790602; rs11433380; rs35977240; rs34762028; rs34472070; rs35306814; rs34739171; rs41408848; rs36095612; rs11552811; rs34829074; rs5818942; rs12150539; rs11554619; rs1045734; rs35144534; rs28692508; rs6145959; rs35110702; rs35514092; rs28665988; rs12938587; rs10593474; rs36062523; rs7221389; rs13200; rs9912524; rs28756069; rs12451452; rs3169614; rs28460112; rs11426758; rs35121541; rs34166093; rs34120182; rs1137718; rs8078322; rs34973529; rs11552810; rs9890897; rs11871948; rs28577048; rs35886530; rs8568; rs33950725; rs5003080; rs4790612; rs9901888; rs35044180; rs34014821; rs5818947; rs35066726; rs34732602; rs28524071; rs36099482; rs9674701; rs9910193; rs9674837; rs5818952; rs2325981; rs11078496; rs8078393; rs10713986; rs35264067; rs8069612; rs35897766; rs41356550; rs7208636; rs28536065; rs5003079; rs35288114; rs35123697; rs9941393; rs8082123; rs35482444; rs9907368; rs11657111; rs8073190; rs11410197; rs5818946; rs35550125; rs9897965; rs9907880; rs35412900; rs5818951; rs4357975; rs34190346; rs34209253; rs7220341; rs35005458; rs8182295; rs2006746; rs2325980; rs34334033; rs11437680; rs8064744; rs893381; rs35006294; rs35048765; rs10669832; rs10536668; rs35669810; rs36076476; rs35867792; rs35618711; rs35860249; rs7219792; rs7224148; rs2325985; rs3859211; rs35466443; rs1806893; rs6145961; rs8073409; rs9904114; rs35112203; rs9900787; rs8075151; rs35774067; rs2325940; rs34344004; rs1017445; rs1814417; rs8075816; rs11312770; rs747018; rs35329682; rs34499321; rs28718128; rs2875769; rs35054040; rs35451246; rs9674759; rs35543042; rs34074223; rs35383082; rs34558166; rs10648352; rs8077526; rs7219610; rs35538704; rs7214818; rs8070832; rs35513053; rs7219326; rs2325984; rs10646759; rs5818944; rs12450394; rs11331976; rs1806894; rs4527054; rs9909517; rs35809414; rs5818953; rs35491296; rs2004167; rs34357475; rs35700313; rs34756703; rs34262221; rs35681890; rs35697454; rs10713987; rs35129977; rs34464833; rs11458832; rs7504037; rs34402771; rs35118148; rs12945770; rs34675132; rs8070343; rs2325983; rs8182323; rs28667146; rs28580153; rs4790608; rs35213299; rs2875767; rs35969540; rs34313850; rs5818943; rs35778646; rs34315189; rs35792021; rs35390166; rs4448984; rs33942951; rs35941094; rs4790607; rs10635540; rs4605199; rs3050966; rs5818948; rs35683129; rs10671865; rs35249889; rs35666067; rs4464134; rs4790601; rs7215309; rs7216134; rs8069769; rs924026; rs9906760

# Metabolic_Enzyme_26_General_References:
8893823; 12665801

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5852

# Metabolic_Enzyme_27_Name:
Glutaminyl-tRNA synthetase

# Metabolic_Enzyme_27_Synonyms:
Glutamine--tRNA ligase; GlnRS

# Metabolic_Enzyme_27_Gene_Name:
QARS

# Metabolic_Enzyme_27_Protein_Sequence:
>GlutaminyltRNA synthetase
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLA
SRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPE
QIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPK
LEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKT
PGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL
RFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQ
RGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRV
KYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPV
QWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVG
VTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADET
KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVES
LEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASL
HVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV

# Metabolic_Enzyme_27_Number_of_Residues:
775

# Metabolic_Enzyme_27_Molecular_Weight:
87800

# Metabolic_Enzyme_27_Theoretical_pI:
7.16

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  glutamate-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  glutamine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  glutamyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_27_Specific_Function:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

# Metabolic_Enzyme_27_Pathway:
map00251  Glutamate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_27_Reaction:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00749:tRNA-synt_1c;
PF03950:tRNA-synt_1c_C;
PF04558:tRNA_synt_1c_R1;
PF04557:tRNA_synt_1c_R2

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 6.1.1.18

# Metabolic_Enzyme_27_GenBank_ID_Protein:
558586

# Metabolic_Enzyme_27_SwissProt_ID:
SYQ_HUMAN (P47897)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
QARS

# Metabolic_Enzyme_27_Geneatlas_id:
QARS

# Metabolic_Enzyme_27_hgnc_id:
HGNC:9751

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_27_Gene_Sequence:
>2328 bp
ATGGCGGCTCTAGACTCCCTGTCGCTCTTCACTAGCCTCGGCCTGAGCGAGCAGAAGGCC
CGCGAGACGCTCAAGAACTCGGCTCTGAGCGCGCAGCTGCGCGAGGCCGCTACTCAGGCT
CAGCAGACCCTGGGTTCCACCATTGACAAAGCTACCGGGATCCTGTTATATGGCTTGGCC
TCCCGACTCAGGGATACCCGGCGTCTCTCCTTCCTTGTAAGCTACATAGCCAGTAAGAAG
ATCCACACTGAGCCCCAGCTAAGCGCTGCCCTTGAGTATGTGCGGAGTCACCCCTTGGAC
CCCATCGACACTGTGGACTTCGAGCGGGAATGTGGCGTGGGTGTCATTGTGACCCCAGAG
CAGATTGAGGAGGCTGTGGAGGCTGCTATTAACAGGCACCGGCCCCAGCTCCTGGTGGAA
CGTTACCATTTCAACATGGGGCTGCTGATGGGAGAGGCTCGGGCTGTGCTGAAGTGGGCA
GATGGCAAAATGATCAAGAATGAAGTGGACATGCAGGTCCTCCACCTTCTGGGCCCCAAG
TTGGAGGCTGATCTGGAGAAGAAGTTCAAGGTGGCAAAAGCTCGGCTAGAAGAAACAGAC
CGGAGGACGGCAAAGGATGTGGTGGAGAATGGCGAGACTGCTGACCAGACCCTGTCTCTG
ATGGAGCAGCTCCGGGGGGAGGCCCTTAAGTTCCACAAGCCTGGTGAGAACTACAAGACC
CCAGGCTATGTGGTCACTCCACACACCATGAATCTACTAAAGCAGCACCTGGAGATTACT
GGTGGGCAGGTACGTACCCGGTTCCCGCCAGAACCCAATGGAATCCTGCATATTGGACAT
GCCAAAGCCATCAATTTCAACTTTGGCTATGCCAAGGCCAACAATGGCATCTGTTTTCTG
CGTTTTGATGACACCAACCCTGAGAAGGAGGAAGCAAAGTTCTTCACGGCCATCTGTGAC
ATGGTAGCCTGGCTAGGCTACACACCTTACAAAGTCACATATGCGTCTGACTATTTTGAC
CAGCTATATGCGTGGGCTGTGGAGCTCATCCGCAGGGGTCTGGCTTATGTGTGCCACCAG
CGAGGAGAGGAGCTCAAAGGCCATAATACTCTGCCTTCACCCTGGAGAGACCGTCCCATG
GAGGAGTCACTGCTGCTCTTTGAGGCAATGCGCAAGGGCAAGTTTTCAGAGGGCGAGGCC
ACACTACGGATGAAGCTGGTGATGGAGGATGGCAAGATGGACCCTGTAGCCTATCGAGTC
AAGTATACACCACACCACCGCACAGGGGACAAATGGTGCATCTATCCCACCTACGACTAC
ACACACTGCCTCTGTGACTCCATCGAGCACATCACTCACTCACTCTGCACCAAGGAATTC
CAGGCCCGACGCTCTTCCTACTTCTGGCTTTGCAATGCACTGGACGTCTATTGCCCTGTG
CAGTGGGAGTATGGCCGCCTCAACCTGCACTATGCTGTTGTCTCTAAGAGGAAGATCCTC
CAGCTTGTAGCAACTGGTGCTGTGCGGGACTGGGATGACCCACGGCTCTTTACACTCACG
GCCCTGCGACGGCGGGGCTTCCCACCTGAGGCCATCAACAACTTCTGTGCCCGGGTGGGA
GTGACTGTGGCACAAACCACAATGGAGCCACATCTTCTAGAAGCCTGTGTGCGTGATGTG
CTGAATGACACAGCCCCACGAGCCATGGCTGTGCTGGAGTCACTACGGGTCATCATCACC
AACTTTCCTGCTGCCAAGTCCTTGGACATCCAGGTGCCCAACTTCCCAGCTGATGAGACC
AAAGGCTTCCATCAGGTTCCCTTTGCACCCATTGTCTTCATTGAGAGGACTGACTTCAAG
GAGGAGCCAGAGCCAGGATTTAAGCGCCTGGCTTGGGGCCAGCCTGTGGGCCTGAGGCAT
ACAGGCTACGTCATTGAGCTGCAGCATGTTGTCAAGGGCCCCAGTGGTTGTGTAGAGAGT
CTGGAGGTGACCTGCAGACGGGCAGATGCTGGAGAGAAGCCAAAGGCCTTTATTCACTGG
GTGTCACAGCCTTTGATGTGTGAGGTTCGCCTCTATGAGCGACTATTCCAGCACAAGAAC
CCTGAAGATCCTACTGAGGTGCCTGGTGGATTTTTAAGTGACCTGAACCTGGCATCACTA
CACGTGGTGGATGCAGCATTAGTGGACTGCTCTGTGGCCCTGGCAAAACCCTTCGACAAG
TTCCAGTTTGAGCGTCTTGGATATTTCTCCGTGGATCCAGACAGCCATCAGGGAAAGCTT
GTCTTTAACCGAACTGTCACACTGAAGGAAGACCCAGGAAAGGTGTGA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
X76013

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_27_Locus:
3p21.3-p21.1

# Metabolic_Enzyme_27_SNPs:
rs5030795; rs4521268; rs4513485; rs13064784; rs4955426; rs11539148; rs5008949; rs1131331; rs1140525; rs13081176; rs35281792; rs35083448; rs34326553; rs13059023; rs35796732; rs13100657; rs35673421; rs4128204; rs34333933; rs7613975; rs13321689; rs14644; rs3212; rs4292260; rs4292261; rs4355315; rs4955411; rs6780307; rs6782515; rs6782540; rs9840050; rs9857248; rs9863398; rs9877045

# Metabolic_Enzyme_27_General_References:
8078941

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5853

# Metabolic_Enzyme_28_Name:
Threonyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_28_Synonyms:
Threonine--tRNA ligase; ThrRS

# Metabolic_Enzyme_28_Gene_Name:
TARS

# Metabolic_Enzyme_28_Protein_Sequence:
>ThreonyltRNA synthetase, cytoplasmic
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF

# Metabolic_Enzyme_28_Number_of_Residues:
723

# Metabolic_Enzyme_28_Molecular_Weight:
83436

# Metabolic_Enzyme_28_Theoretical_pI:
6.64

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  threonine-tRNA ligase activity
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  transporter activity
Function:  electron transporter activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  threonyl-tRNA aminoacylation
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_28_Specific_Function:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_28_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_28_Reaction:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF02824:TGS;
PF00587:tRNA-synt_2b;
PF07973:tRNA_SAD

# Metabolic_Enzyme_28_Signals:
None

# Metabolic_Enzyme_28_Transmembrane_Regions:
None

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 6.1.1.3

# Metabolic_Enzyme_28_GenBank_ID_Protein:
1464742

# Metabolic_Enzyme_28_SwissProt_ID:
SYTC_HUMAN (P26639)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
TARS

# Metabolic_Enzyme_28_Geneatlas_id:
TARS

# Metabolic_Enzyme_28_hgnc_id:
HGNC:11572

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_28_Gene_Sequence:
>2139 bp
ATGGGAGGCGAGGAGAAGCCGATTGGTGCTGGTGAAGAGAAGCAAAAGGAAGGAGGCAAA
AAGAAGAACAAAGAAGGATCTGGAGATGGAGGTCGAGCTGAGTTGAATCCTTGGCCTGAA
TATATTTACACACGTCTTGAGATGTATAATATACTAAAAGCAGAACATGATTCCATTCTG
GCAGAAAAGGCAGAAAAAGATAGCAAGCCAATTAAAGTCACTTTGCCTGATGGTAAACAG
GTTGATGCGGAATCTTGGAAAACTACACCATATCAAATTGCCTGTGGAATTAGTCAAGGC
CTGGCCGACAACACCGTTATTGCTAAAGTAAATAATGTTGTGTGGGACCTGGACCGCCCT
CTGGAAGAAGATTGTACCTTGGAGCTTCTCAAGTTTGAGGATGAGGAAGCTCAGGCAGTG
TATTGGCACTCTAGTGCTCACATAATGGGTGAAGGCATGGAAAGAGTCTATGGTGGATGT
TTATGCTACGGTCCGCCAATAGAAAATGGATTCTATTATGACATGTACCTCGAAGAAGGG
GGTGTGTCTAGCAATGATTTCTCTTCTCTGGAGGCTTTGTGTAAGAAAATCATTAAAGAA
AAACAAGCTTTTGAAAGACTGGAAGTTAAGAAAGAAACTTTACTGGCAATGTTTAAGTAC
AACAAGTTCAAATGCCGGATATTGAATGAAAAGGTGAATACTCCAACTACCACAGTCTAT
AGATGTGGCCCTTTGATAGATCTCTGCCGGGGTCCTCATGTTAGACACACGGGCAAAATT
AAGGCTTTAAAAATACACAAAAATTCCTCCACGTACTGGGAAGGCAAAGCAGATATGGAG
ACTCTCCAGAGAATTTATGGCATTTCATTCCCAGATCCTAAAATGTTGAAAGAGTGGGAG
AAGTTCCAAGAGGAAGCTAAAAACCGAGATCATAGGAAAATTGGCAGGGACCAAGAACTA
TATTTCTTTCATGAACTCAGCCCTGGAAGTTGCTTTTTTCTGCCAAAAGGAGTCTATATT
TATAATGCACTTATTGAATTCATTAGGAGCGAATATAGGAAAAGAGGATTCCAGGAGGTA
GTCACCCCAAACATCTTCAACAGCCGACTCTGGATGACCTCGGGCCACTGGCAGCACTAC
AGCGAGAACATGTTCTCCTTTGAGGTGGAGAAGGAGCTGTTTGCCCTGAAACCCATGAAC
TGCCCAGGACACTCCCTTATGTTTGATCATCGGCCAAGGTCCTGGCGAGAACTGCCTCTG
CGGCTAGCTGATTTTGGGGGTCTTCATAGGAACGAGCTGTCTGGAGCACTCACAGGACTC
ACCCGGGTACGAAGATTCCAACAGGATGATGCTCACATATTCTGTGCCATGGAGCAGATT
GAAGATGAAATAAAAGGTTGTTTGGATTTTCTACGTACGGTATATAGCGTATTTGGATTT
TCTTTTAAACTAAACCTTTCTACTCGCCCGGAAAAATTCCTTGGAGATATCGAAGTATGG
GATCAAGCTGAGAAACAACTTGAAAACAGTCTGAATGAATTTGGTGAAAAGTGGGAGTTA
AACTCTGGAGATGGAGCTTTCTATGGCCCAAAGATTGACATACAGATTAAAGATGCGATT
GGGCGGTACCACCAGTGTGCAACCATCCAGCTGGATTTCCAGTTGCCCATCAGATTTAAT
CTTACTTATGTAAGCCATGATGGTGAGGATAAGAAAAGGCCAGTGATTGTTCATCGAGCC
ATCTTGGGATCAGTGGAAAGAATGATTGCTATCCTCACAGAAAACTATGGGGGCAAATTG
GCCCCCTTTTGGCTGTCCCCTCGCCAGGTAATGGTAGTTCCAGTGGGACCAACCTGTGAT
GAATATGCCCAAAACGTACGACAACAATTCCACGATGCCAAATTCATGGCAGACATTGAT
CTGGATCCAGGCTGTACATTGAATAAAAAGATTCGAAATGCACAGTTAGCACAGTATAAC
TTCATTTTAGTTGTTGGTGAAAAAGAGAAAATCACTGGCACTGTTAATATCCGCACAAGA
GACAATAAGGTCCACGGGGAACGCACCATTTCTGAAACTATCGAGCGGCTACAGCAGCTC
AAAGAGTTCCGCAGCAAACAGGCAGAAGAAGAATTTTAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
M63180

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_28_Locus:
5p13.2

# Metabolic_Enzyme_28_SNPs:
rs16891129; rs34334786; rs2270902; rs3736393; rs2270905; rs7261; rs2304621; rs28362597; rs3765145; rs1003000; rs6450990; rs893551; rs2292015; rs3849682; rs3777083; rs3777081; rs3777079; rs7705177; rs6887261; rs6884566; rs3765146; rs2270903; rs3777077; rs3777076; rs3777082; rs6893613; rs16891189; rs10941055; rs9686398; rs12659798; rs6450991; rs3777075; rs11955272; rs11955289; rs3777074; rs3849683; rs3765144; rs3765147; rs3777078; rs6885094; rs12522185; rs6866808; rs16891141; rs6880623; rs3830415; rs12517884; rs4867513; rs4421109; rs3215116; rs6880616; rs16891180; rs2270904; rs4867512; rs16891143; rs2292014; rs3777073; rs7734078; rs12520517; rs3756661; rs3756664; rs3756663; rs3756662; rs6870521; rs11742862; rs16891125; rs1804513; rs1051213; rs11541416; rs1051210; rs1131566; rs1051211; rs34715628; rs16891192; rs34673293; rs33932086; rs17565038; rs12187755; rs5867191; rs35931457; rs5022546; rs10583985; rs11356243; rs12187715; rs2642668; rs34875186; rs28475744; rs3842066; rs35121278; rs34630295; rs9885230; rs12187727; rs12188515; rs35817175; rs11747025; rs11457738; rs13154531; rs4267874; rs34910729; rs34725061; rs4398642; rs1687511; rs2642669; rs35375523; rs13184927; rs34596299; rs11952399; rs3777080; rs11414360; rs11383852; rs11422595; rs13164529; rs11960553; rs34580645; rs34374932; rs17455135; rs5867190; rs35331115; rs35079782; rs5867189; rs2453288; rs2164991; rs6889780; rs36102914; rs35558849; rs1080; rs11950608; rs12054982; rs12514530; rs1438728; rs1542031; rs1542998; rs16891198; rs16891202; rs4867143; rs6885517; rs7702124; rs925210

# Metabolic_Enzyme_28_General_References:
2033077

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5610

# Metabolic_Enzyme_29_Name:
Glycogen phosphorylase, muscle form

# Metabolic_Enzyme_29_Synonyms:
Myophosphorylase

# Metabolic_Enzyme_29_Gene_Name:
PYGM

# Metabolic_Enzyme_29_Protein_Sequence:
>Glycogen phosphorylase, muscle form
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI

# Metabolic_Enzyme_29_Number_of_Residues:
842

# Metabolic_Enzyme_29_Molecular_Weight:
97093

# Metabolic_Enzyme_29_Theoretical_pI:
7.03

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_29_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_29_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_29_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_29_GenBank_ID_Protein:
190784

# Metabolic_Enzyme_29_SwissProt_ID:
PYGM_HUMAN (P11217)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
PYGM

# Metabolic_Enzyme_29_Geneatlas_id:
PYGM

# Metabolic_Enzyme_29_hgnc_id:
HGNC:9726

# Metabolic_Enzyme_29_PDB_ID:
1XL1

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>2529 bp
ATGTCCCGGCCCCTGTCAGACCAAGAGAAAAGAAAGCAAATCAGTGTGCGTGGCCTGGCC
GGCGTGGAGAACGTGACTGAGCTGAAAAAGAACTTCAACCGGCACCTGCATTTCACACTC
GTAAAGGACCGCAATGTGGCCACCCCACGAGACTACTACTTTGCTCTGGCCCATACCGTG
CGCGACCACCTCGTGGGGCGGTGGATCCGCACGCAGCAGCACTACTATGAGAAGGACCCC
AAGAGGATCTACTACCTGTCTTTAGAGTTCTATATGGGACGGACGCTACAGAACACCATG
GTGAACCTGGCCTTAGAGAATGCCTGTGACGAGGCCACCTACCAGCTGGGCCTGGACATG
GAGGAGCTGGAGGAAATTGAGGAGGATGCGGGGCTGGGCAACGGGGGCCTGGGCCGGCTG
GCAGCCTGCTTTCTTGACTCCATGGCAACACTGGGCCTGGCTGCCTATGGCTACGGGATT
CGCTATGAGTTTGGGATTTTTAACCAGAAGATCTCCGGGGGCTGGCAGATGGAGGAGGCC
GATGACTGGCTTCGCTACGGCAACCCCTGGGAGAAGGCCCGGCCCGAGTTCACGCTACCT
GTGCACTTCTACGGCCATGTGGAGCACACCAGCCAGGGTGCCAAGTGGGTGGACACACAG
GTGGTACTGGCCATGCCCTACGATACCCCGGTGCCTGGCTATCGCAACAATGTTGTCAAC
ACCATGCGCCTCTGGTCTGCCAAGGCTCCCAATGACTTCAACCTCAAGGACTTCAATGTC
GGTGGCTACATCCAGGCTGTGTTGGACCGAAACCTGGCGGAGAACATCTCTCGTGTCCTG
TACCCCAATGATAATTTCTTCGAAGGGAAGGAGCTGCGGCTGAAGCAGGAGTATTTCGTG
GTGGCTGCCACCCTCCAGGACATCATCCGTCGCTTCAAGTCTTCCAAGTTCGGCTGCCGT
GATCCCGTGCGCACGAACTTCGATGCCTTCCCAGATAAGGTGGCCATCCAGCTCAATGAC
ACCCACCCCTCCCTGGCCATCCCCGAGCTGATGAGGATCCTGGTGGACCTGGAACGGATG
GACTGGGACAAGGCGTGGGATGTGACAGTGAGGACCTGTGCCTACACCAACCACACGGTG
CTGCCCGAGGCCCTGGAGCGCTGGCCGGTGCACCTCTTGGAGACGCTGCTGCCGCGGCAC
CTCCAGATCATCTACGAGATCAACCAGCGCTTCCTCAACCGGGTGGCGGCCGCATTCCCA
GGGGACGTAGACCGGCTGCGGCGCATGTCGCTGGTGGAGGAGGGCGCAGTGAAGCGCATC
AACATGGCACACCTGTGCATCGCGGGGTCGCACGCCGTCAACGGTGTGGCCCGCATCCAC
TCGGAGATCCTCAAGAAGACCATCTTCAAAGACTTCTATGAGCTGGAGCCTCATAAGTTC
CAGAATAAGACCAACGGCATCACCCCTCGGCGCTGGCTGGTTCTGTGTAACCCCGGGCTG
GCAGAGGTCATTGCTGAGCGCATCGGGGAGGACTTCATCTCTGACCTGGACCAGCTGCGC
AAACTGCTCTCCTTTGTGGATGATGAAGCTTTCATTCGGGATGTGGCCAAAGTGAAGCAG
GAAAACAAGTTGAAGTTTGCTGCCTACCTAGAGAGGGAATACAAAGTCCACATCAACCCC
AACTCACTCTTCGACATCCAGGTGAAGCGGATTCACGAATATAAACGACAGCTCCTCAAC
TGCCTCCATGTCATCACCCTGTACAACCGCATCAAGAGGGAGCCCAATAAGTTTTTTGTG
CCTCGGACTGTGATGATTGGAGGGAAGGCTGCACCTGGGTACCACATGGCCAAGATGATC
ATCAGACTCGTCACAGCCATCGGGGATGTGGTCAACCATGACCCGGCAGTGGGTGACCGC
CTCCGTGTCATCTTCCTGGAGAACTACCGAGTCTCACTGGCCGAGAAAGTGATCCCAGCT
GCAGACCTCTCTGAGCAGATCTCCACTGCGGGCACTGAAGCCTCAGGCACCGGCAACATG
AAGTTCATGCTCAACGGGGCTCTGACCATTGGCACCATGGACGGGGCCAATGTGGAGATG
GCAGAAGAGGCGGGAGAGGAAAACTTCTTCATCTTTGGCATGCGGGTGGAGGATGTGGAT
AAGCTTGACCAAAGAGGGTACAATGCCCAGGAGTACTACGATCGCATTCCTGAGCTTCGG
CAGGTCATTGAGCAGCTGAGCAGTGGCTTCTTCTCCCCCAAACAACCCGACCTGTTCAAG
GACATTGTCAATATGCTCATGCACCATGACCGGTTTAAAGTCTTCGCAGATTATGAAGAC
TACATTAAATGCCAGGAGAAAGTCAGCGCCTGGTACAAGAACCCAAGAGAGTGGACGCGG
ATGGTGATCCGGAACATAGCCACTTCTGGCAAGTTCTCCAGTGACCGCACCATTGCCCAG
TATGCCCGGGAGATCTGGGGTGTGGAGCCTTCCCGCCAGCGCCTGCCAGCCCCGGATGAG
GCCATCTGA

# Metabolic_Enzyme_29_GenBank_ID_Gene:
M32598

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_29_Locus:
11q12-q13.2

# Metabolic_Enzyme_29_SNPs:
rs483962; rs489192; rs686171; rs547066; rs477549; rs565688; rs490980; rs7938455; rs592521; rs589691; rs625172; rs592532; rs506354; rs532747; rs592546; rs474006; rs7126110; rs2959652; rs566653; rs630966; rs637332; rs11821081; rs604595; rs11231866; rs2230309; rs1212604; rs11231865; rs1056780; rs28940587; rs669572; rs12278323; rs9704315; rs34267133; rs3202054; rs576632; rs34991365; rs2071320; rs34447097; rs34154523; rs608261; rs28398896; rs1207113; rs550545; rs555974; rs7114931; rs569200; rs608257; rs7104895; rs34195091; rs35447888; rs34978393; rs2071318; rs11308610; rs12364023; rs2284302; rs34338262; rs35958437; rs35091627; rs35071540; rs1803954; rs1804549; rs2073797; rs2073798; rs2277308; rs2277309; rs2301563; rs2904961; rs2959650; rs3168088; rs3759049; rs3759051; rs3759052; rs3891505; rs484886; rs523200; rs546323; rs547280; rs550930; rs561158; rs588139; rs610637; rs620006; rs637732; rs681791

# Metabolic_Enzyme_29_General_References:
3447177; 3840433; 3466902; 8316268; 8535454; 7603523; 9506549; 10417800; 10382911; 10382912; 10681080; 10590419; 10714589; 10899452; 11706962; 12031624

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5854

# Metabolic_Enzyme_30_Name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

# Metabolic_Enzyme_30_Synonyms:
cGMP phosphodiesterase 6C

# Metabolic_Enzyme_30_Gene_Name:
PDE6C

# Metabolic_Enzyme_30_Protein_Sequence:
>Cone cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha'
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML

# Metabolic_Enzyme_30_Number_of_Residues:
858

# Metabolic_Enzyme_30_Molecular_Weight:
99148

# Metabolic_Enzyme_30_Theoretical_pI:
5.45

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_30_GenBank_ID_Protein:
940231

# Metabolic_Enzyme_30_SwissProt_ID:
PDE6C_HUMAN (P51160)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
PDE6C

# Metabolic_Enzyme_30_Geneatlas_id:
PDE6C

# Metabolic_Enzyme_30_hgnc_id:
HGNC:8787

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_30_Gene_Sequence:
>2577 bp
ATGGGTGAGATCAACCAAGTTGCCGTGGAGAAATACCTGGAGGAGAACCCTCAGTTTGCC
AAGGAGTACTTTGACAGGAAGTTGCGGGTGGAGGTGCTGGGAGAAATCTTCAAGAACAGC
CAGGTGCCAGTCCAGTCCAGCATGTCCTTCTCTGAGCTGACCCAGGTGGAGGAGTCAGCC
CTGTGCTTGGAGCTGCTGTGGACCGTGCAGGAGGAGGGGGGCACCCCAGAGCAGGGGGTT
CACAGGGCCCTACAGAGGCTGGCCCACCTGCTCCAGGCTGACCGCTGCAGCATGTTCCTG
TGCCGGTCCCGGAACGGCATACCTGAGGTGGCCTCTAGGTTGCTGGTAGTCACCCCCACC
TCCAAGTTTGAGGACAACCTGGTGGGCCCTGACAAAGAAGTTGTGTTTCCATTGGACATT
GGGATAGTGGGTTGGGCTGCTCACACGAAGAAAACTCATAATGTCCCAGATGTGAAAAAG
AACAGCCATTTTTCTGACTTCATGGACAAGCAAACTGGGTATGTCACTAAGAACCTGCTG
GCAACCCCGATCGTGGTGGGCAAGGAGGTTCTTGCTGTGATCATGGCAGTTAACAAAGTA
AATGCATCTGAATTTTCCAAACAGGATGAAGAGGTCTTTTCCAAATACCTCAACTTTGTG
TCTATCATCCTAAGGCTTCATCACACCAGCTACATGTACAATATTGAATCCCGAAGAAGC
CAGATCCTTATGTGGTCAGCCAATAAAGTATTTGAAGAACTCACAGATGTTGAGCGACAG
TTTCACAAAGCGCTCTACACGGTTAGATCATATCTGAACTGTGAACGATACTCCATTGGA
CTGCTGGACATGACCAAGGAGAAGGAATTCTACGATGAATGGCCAATCAAGCTTGGAGAA
GTAGAGCCTTATAAAGGTCCAAAGACACCTGATGGCAGGGAAGTCAACTTTTATAAAATC
ATTGATTACATTTTACATGGAAAAGAAGAGATCAAAGTGATTCCGACGCCTCCTGCAGAC
CACTGGACACTCATTAGTGGGTTGCCAACATATGTTGCTGAAAATGGATTTATCTGTAAC
ATGATGAATGCCCCTGCGGATGAATACTTCACATTTCCGAAAGGACCTGTAGACGAAACT
GGTTGGGTCATTAAGAATGTTTTGTCCCTGCCTATTGTCAACAAGAAAGAAGATATTGTG
GGAGTGGCTACATTTTACAACAGGAAGGATGGAAAACCTTTCGATGAGCATGATGAATAC
ATTACCGAGACTCTCACACAATTTCTTGGATGGTCTCTTTTAAATACTGACACCTACGAT
AAGATGAATAAGCTAGAAAACAGAAAGGACATTGCTCAGGAAATGCTCATGAACCAAACC
AAAGCCACTCTTGAAGAAATTAAGTCCATTTTGAAATTTCAAGAGAAGTTAAATGTTGAT
GTAATTGACGACTGTGAAGAAAAACAACTTGTTGCAATTTTGAAAGAGGACTTGCCAGAC
CCACGCTCAGCAGAACTGTACGAATTCCGCTTCAGTGACTTCCCCCTTACAGAGCACGGA
TTGATTAAATGTGGAATACGACTGTTTTTTGAAATAAATGTGGTGGAGAAATTCAAAGTA
CCTGTAGAGGTTCTTACCAGATGGATGTACACTGTGAGGAAAGGGTACCGAGCTGTCACT
TACCACAATTGGCAGCATGGGTTCAACGTGGGGCAGACCATGTTTACTTTGCTGATGACA
GGAAGATTAAAGAAGTACTACACAGATCTCGAAGCCTTTGCCATGCTTGCTGCTGCTTTC
TGCCATGATATTGACCACAGAGGCACCAATAATTTGTACCAGATGAAATCCACGTCTCCA
TTAGCAAGACTTCATGGTTCTTCTATTTTGGAGAGGCACCACCTGGAGTACAGTAAGACT
CTGTTGCAGGATGAGAGTTTAAACATCTTCCAGAACCTAAATAAGCGGCAGTTTGAAACA
GTTATTCATTTGTTCGAGGTCGCAATAATAGCAACTGACCTGGCTTTATATTTCAAGAAG
AGGACCATGTTTCAAAAAATTGTTGATGCCTGTGAACAAATGCAAACGGAAGAAGAAGCC
ATCAAATATGTAACTGTTGATCCAACCAAGAAAGAGATTATCATGGCAATGATGATGACG
GCATGTGACTTGTCTGCTATTACCAAGCCCTGGGAGGTGCAAAGTCAGGTAGCACTTATG
GTTGCAAATGAATTTTGGGAACAAGGAGATCTGGAGAGAACAGTGTTGCAGCAACAACCC
ATTCCTATGATGGACAGAAACAAAAGAGATGAATTACCTAAACTTCAAGTTGGATTTATT
GATTTTGTTTGTACTTTTGTATATAAGGAGTTCTCACGGTTTCACAAAGAAATCACACCT
ATGCTGAGTGGTCTTCAGAATAACAGAGTAGAATGGAAATCACTAGCTGATGAGTATGAT
GCAAAGATGAAGGTCATTGAAGAGGAGGCAAAAAAGCAAGAAGGAGGAGCCGAAAAAGCT
GCTGAAGATTCAGGAGGTGGTGATGACAAAAAGTCCAAAACATGTTTAATGTTGTAA

# Metabolic_Enzyme_30_GenBank_ID_Gene:
U31973

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_30_Locus:
10q24

# Metabolic_Enzyme_30_SNPs:
rs701865; rs714550; rs3737228; rs1131978; rs12781149; rs554062; rs650058; rs588912; rs2077733; rs616522; rs637959; rs1326217; rs1223306; rs2422324; rs487161; rs1409332; rs716333; rs2104497; rs2422326; rs591392; rs2857300; rs1147644; rs1018634; rs913046; rs7080485; rs829107; rs2785137; rs6583900; rs720298; rs725888; rs10786119; rs4917871; rs10882289; rs503758; rs11187554; rs2857293; rs604489; rs12266365; rs10748607; rs481031; rs3781273; rs2901714; rs7903947; rs620043; rs1147645; rs677517; rs7095788; rs1147643; rs640090; rs3824752; rs1326219; rs583830; rs1223308; rs10786121; rs10882291; rs714549; rs12249716; rs716332; rs2275227; rs473934; rs517785; rs4919340; rs829109; rs7919662; rs7080650; rs1409334; rs11187570; rs17485621; rs559590; rs618951; rs659145; rs564626; rs547759; rs10882294; rs1326218; rs3781279; rs620890; rs10882288; rs1764322; rs7076251; rs714551; rs10882292; rs11187574; rs6583901; rs2422327; rs11187573; rs2765828; rs12412552; rs12264082; rs590226; rs1409335; rs10882293; rs1409333; rs1223307; rs17109153; rs10882297; rs17109017; rs2148295; rs2094210; rs9419777; rs12260939; rs10882298; rs12265671; rs1856563; rs1147642; rs2148296; rs515656; rs17109134; rs12252727; rs4919314; rs2184777; rs2014325; rs7476647; rs10882287; rs11187560; rs17109081; rs11187575; rs17407606; rs17109131; rs2785140; rs10882296; rs12261871; rs7075895; rs10882290; rs7097667; rs7095955; rs11814998; rs7917510; rs11187566; rs11187572; rs11187555; rs7893369; rs12217346; rs12261990; rs11187578; rs6583903; rs2857302; rs2422325; rs2785144; rs11187571; rs7910799; rs4454655; rs11187577; rs11187563; rs12217337; rs11187556; rs2009687; rs11814382; rs4919339; rs1223305; rs7094543; rs1223295; rs12246423; rs11187561; rs11187569; rs4282926; rs11187564; rs10786120; rs7893372; rs1223309; rs12251269; rs11187562; rs1096025; rs6583902; rs4919344; rs12252137; rs12266501; rs12260671; rs11597224; rs12261131; rs41290222; rs1051925; rs1051926; rs2785143; rs34556446; rs35991228; rs2785136; rs1934332; rs12244942; rs7091068; rs12780304; rs35383563; rs2857298; rs35646712; rs2857296; rs685932; rs11458791; rs12220088; rs1223296; rs11187559; rs11187568; rs2184776; rs2785142; rs10576959; rs2859742; rs3781276; rs2859743; rs12784096; rs2857297; rs11187576; rs4322325; rs7901817; rs2857295; rs12246400; rs3781272; rs3831275; rs7100627; rs11187553; rs2785138; rs5787071; rs35142602; rs35544970; rs35302473; rs7897417; rs7084398; rs36000137; rs35178949; rs2765830; rs10691352; rs11187565; rs514120; rs1934333; rs2785139; rs7900772; rs34173771; rs2765831; rs10680592; rs4919390; rs35484151; rs1750634; rs34507085; rs7903992; rs12049686; rs35175655; rs7909769; rs34414687; rs4539248; rs4590795; rs35868180; rs10666338; rs36102645; rs35822924; rs7904127; rs10699606; rs2484928; rs587034; rs1096027; rs5787069; rs12254107; rs34756107; rs3904734; rs3085185; rs35818357; rs11364728; rs2857301; rs34861265; rs1096026; rs2765829; rs7907905; rs11187557; rs11418985; rs10548834; rs34919813; rs4558100; rs11187552; rs12220915; rs34008461; rs634750; rs34327978; rs4917865; rs34108261; rs2857299; rs35656775; rs3085187; rs474709; rs41303821; rs12412251; rs1326216; rs1013889; rs11187558; rs2785134; rs35245452; rs7475724; rs12779737; rs12260900; rs2857294; rs2785133; rs12260745; rs9419778; rs12260744; rs10159893; rs10786117; rs1108197; rs11187549; rs11187579; rs11187580; rs12219497; rs12255765; rs12265776; rs12415773; rs12573026; rs1326215; rs1547173; rs1572772; rs1572773; rs17108993; rs17108996; rs17486669; rs34803976; rs35180415; rs3740369; rs3765581; rs4144098; rs7904844; rs913045

# Metabolic_Enzyme_30_General_References:
7490077

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
5233

# Metabolic_Enzyme_31_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_31_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_31_Gene_Name:
NT5C1A

# Metabolic_Enzyme_31_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_31_Number_of_Residues:
368

# Metabolic_Enzyme_31_Molecular_Weight:
41021

# Metabolic_Enzyme_31_Theoretical_pI:
6.52

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_31_General_Function:
Not Available

# Metabolic_Enzyme_31_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_31_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_31_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_31_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_31_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
NT5C1A

# Metabolic_Enzyme_31_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_31_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_31_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_31_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_31_Locus:
1p34.3-p33

# Metabolic_Enzyme_31_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_31_General_References:
11133996

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5855

# Metabolic_Enzyme_32_Name:
Asparagine synthetase [glutamine-hydrolyzing]

# Metabolic_Enzyme_32_Synonyms:
Glutamine- dependent asparagine synthetase; Cell cycle control protein TS11

# Metabolic_Enzyme_32_Gene_Name:
ASNS

# Metabolic_Enzyme_32_Protein_Sequence:
>Asparagine synthetase glutaminehydrolyzing
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ
PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV
FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF
LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN
NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV
IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF
LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS
WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK
WINATDPSARTLTHYKSAVKA

# Metabolic_Enzyme_32_Number_of_Residues:
561

# Metabolic_Enzyme_32_Molecular_Weight:
64371

# Metabolic_Enzyme_32_Theoretical_pI:
6.85

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  asparagine synthase (glutamine-hydrolyzing) activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  asparagine synthase (glutamine-hydrolyzing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  aspartate family amino acid metabolism
Process:  asparagine metabolism
Process:  asparagine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_32_Specific_Function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_32_Pathway:
map00252  Alanine and aspartate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_32_Reaction:
ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF00733:Asn_synthase;
PF00310:GATase_2

# Metabolic_Enzyme_32_Signals:
None

# Metabolic_Enzyme_32_Transmembrane_Regions:
None

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 6.3.5.4

# Metabolic_Enzyme_32_GenBank_ID_Protein:
179100

# Metabolic_Enzyme_32_SwissProt_ID:
ASNS_HUMAN (P08243)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
ASNS

# Metabolic_Enzyme_32_Geneatlas_id:
ASNS

# Metabolic_Enzyme_32_hgnc_id:
HGNC:753

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Not Available

# Metabolic_Enzyme_32_Gene_Sequence:
>1686 bp
ATGTGTGGCATTTGGGCGCTGTTTGGCAGTGATGATTGCCTTTCTGTTCAGTGTCTGAGT
GCTATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATAC
ACCAACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAG
CCAATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAAC
CATAAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATA
ATCCTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTG
TTTGCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATAT
GGAGTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAA
GCTAAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTT
CTTCCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAA
ATGGTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAG
AAACTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAAT
AATGCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGC
TTGGACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAG
TATCCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGA
AAGGTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGC
ATTCAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGT
GCTTCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTG
ATCTTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCT
CCTTCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTT
GATGTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTT
CTAGATCATCGATTTTTTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAG
AATGGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAA
GAGATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCC
TGGTTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAAT
GCAGCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAA
GTCTTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAG
TGGATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAA
GCTTAG

# Metabolic_Enzyme_32_GenBank_ID_Gene:
M27396

# Metabolic_Enzyme_32_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_32_Locus:
7q21.3

# Metabolic_Enzyme_32_SNPs:
rs1049674; rs6465630; rs7800135; rs4727378; rs7790127; rs11486966; rs11771498; rs17345759; rs17169191; rs3735557; rs11767463; rs17169211; rs17169200; rs3832527; rs17169208; rs2237287; rs7810919; rs7781469; rs10253639; rs12704947; rs7792744; rs1017070; rs7811643; rs2074891; rs7797354; rs2394741; rs4729386; rs4727377; rs17169185; rs4729388; rs17279084; rs2237289; rs17344752; rs12113193; rs4568556; rs1986082; rs10486011; rs10263979; rs2302088; rs11768092; rs13239311; rs10278321; rs17169184; rs7779490; rs12669125; rs4634561; rs17345286; rs7810492; rs17131823; rs11773753; rs4729387; rs17169186; rs11976728; rs1974562; rs3757674; rs10447748; rs3757676; rs3757675; rs17169214; rs7803055; rs12670261; rs12672215; rs13224424; rs2070159; rs11554428; rs3179866; rs1803163; rs11554429; rs11554431; rs1049677; rs3735556; rs34050735; rs11554430; rs35467050; rs34856818; rs3832526; rs13227174; rs34170799; rs28525152; rs10261245; rs6959868; rs28505181; rs36063366; rs13437661; rs10231594; rs35910902; rs28393117; rs13240259; rs28681292; rs41278833; rs2237288; rs12704948; rs13227443; rs41278827; rs10281896; rs28576085; rs10277835; rs36021744; rs13227408; rs41278830; rs10261265; rs41278824; rs13227432; rs35525774; rs12671902; rs13227317; rs13227319; rs34781568; rs13235208; rs35358974; rs35190368; rs34980123; rs28568790; rs13237150; rs36101543; rs36145892; rs13311082; rs12668015; rs28675065; rs35939272; rs34857173; rs10486009; rs10486010; rs11975817; rs13230541; rs2530121; rs6966699; rs7798362; rs7800746; rs9641216

# Metabolic_Enzyme_32_General_References:
2886907; 2565875; 12853948; 3470743; 2569668; 2564390; 2573597

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
5676

# Metabolic_Enzyme_33_Name:
Adenine phosphoribosyltransferase

# Metabolic_Enzyme_33_Synonyms:
APRT

# Metabolic_Enzyme_33_Gene_Name:
APRT

# Metabolic_Enzyme_33_Protein_Sequence:
>Adenine phosphoribosyltransferase
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPG
QRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE


# Metabolic_Enzyme_33_Number_of_Residues:
180

# Metabolic_Enzyme_33_Molecular_Weight:
19608

# Metabolic_Enzyme_33_Theoretical_pI:
5.82

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  adenine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  purine base metabolism
Process:  purine base salvage
Process:  adenine salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_33_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_33_Specific_Function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

# Metabolic_Enzyme_33_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_33_Reaction:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 2.4.2.7

# Metabolic_Enzyme_33_GenBank_ID_Protein:
28819

# Metabolic_Enzyme_33_SwissProt_ID:
APT_HUMAN (P07741)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
APRT

# Metabolic_Enzyme_33_Geneatlas_id:
APRT

# Metabolic_Enzyme_33_hgnc_id:
HGNC:626

# Metabolic_Enzyme_33_PDB_ID:
1ORE

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_33_Gene_Sequence:
>543 bp
ATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCC
ACCCCAGGCGTGGTATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGC
GCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTAC
ATCGCAGGCCTAGACTCCCGAGGCTTCCTCTTTGGCCCCTCCCTGGCCCAGGAGCTTGGA
CTGGGCTGCGTGCTCATCCGAAAGCGGGGGAAGCTGCCAGGCCCCACTCTGTGGGCCTCC
TATTCCCTGGAGTACGGGAAGGCTGAGCTGGAGATTCAGAAAGACGCCCTGGAGCCAGGA
CAGAGGGTGGTCGTCGTGGATGATCTGCTGGCCACTGGTGGAACCATGAACGCTGCCTGT
GAGCTGCTGGGCCGCCTGCAGGCTGAGGTCCTGGAGTGCGTGAGCCTGGTGGAGCTGACC
TCGCTTAAGGGCAGGGAGAAGCTGGCACCTGTACCCTTCTTCTCTCTCCTGCAGTATGAG
TGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
Y00486

# Metabolic_Enzyme_33_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_33_Locus:
16q24

# Metabolic_Enzyme_33_SNPs:
rs8191472; rs8191473; rs2242172; rs8191478; rs8191483; rs3214057; rs8191477; rs8191489; rs8191488; rs8191480; rs8191492; rs2242173; rs8191470; rs8191487; rs8191484; rs8191493; rs8191475; rs8191471; rs537641; rs3826075; rs564235; rs535070; rs8191463; rs3759950; rs541276; rs3759952; rs3759951; rs8191468; rs8191460; rs8191465; rs3826074; rs8191464; rs8191469; rs8191466; rs8191461; rs8191458; rs8191494; rs28999113; rs35148077; rs35095508; rs3169258; rs2911456; rs34926513; rs8191476; rs8191491; rs8191482; rs8191495; rs8191486; rs8191481; rs8191479; rs8191474; rs8191485; rs8191490; rs8191457; rs35132384; rs8191459; rs12929472; rs28712013; rs12929307; rs8191467; rs11076715; rs11076716; rs11076718; rs1141390; rs11640595; rs12932340; rs12935469; rs15829; rs1799825; rs1834065; rs2070256; rs2303271; rs2303272; rs2303273; rs3177509; rs3218720; rs3218721; rs3218722; rs3218723; rs3218724; rs3218725; rs3218726; rs3218727; rs3218728; rs3218729; rs3218730; rs3743548; rs3784890; rs3826065; rs3826066; rs3826067; rs3826068; rs3826069; rs3826070; rs3826071; rs4356464; rs4503779; rs4695; rs475667; rs480727; rs507329; rs510862; rs550269; rs555812; rs559678; rs565211; rs572275; rs8059203; rs8191502; rs8191504; rs8191509

# Metabolic_Enzyme_33_General_References:
3684585; 3554238; 3531209; 12665801; 1746557; 7915931; 3680503; 3343350; 1353080; 11243733

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
5856

# Metabolic_Enzyme_34_Name:
Ubiquitin-conjugating enzyme E2 E2

# Metabolic_Enzyme_34_Synonyms:
Ubiquitin-protein ligase E2; Ubiquitin carrier protein E2; UbcH8

# Metabolic_Enzyme_34_Gene_Name:
UBE2E2

# Metabolic_Enzyme_34_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E2
MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPEREQVQPKKKEGKISSKTAAKLSTSAKRI
QKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPK
VTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQ
YMTNRAEHDRMARQWTKRYAT

# Metabolic_Enzyme_34_Number_of_Residues:
201

# Metabolic_Enzyme_34_Molecular_Weight:
22255

# Metabolic_Enzyme_34_Theoretical_pI:
7.84

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Not Available

# Metabolic_Enzyme_34_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (Probable)

# Metabolic_Enzyme_34_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_34_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_34_GenBank_ID_Protein:
16553859

# Metabolic_Enzyme_34_SwissProt_ID:
UB2E2_HUMAN (Q96LR5)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
UBE2E2

# Metabolic_Enzyme_34_Geneatlas_id:
UBE2E2

# Metabolic_Enzyme_34_hgnc_id:
HGNC:12478

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Not Available

# Metabolic_Enzyme_34_Gene_Sequence:
>606 bp
ATGTCCACTGAGGCACAAAGAGTTGATGACAGTCCAAGCACTAGTGGAGGAAGTTCCGAT
GGAGATCAACGTGAAAGTGTTCAGCAAGAACCAGAAAGAGAACAAGTTCAGCCCAAGAAA
AAGGAGGGAAAAATATCCAGCAAAACCGCTGCTAAATTGTCAACTAGTGCTAAAAGAATT
CAGAAGGAACTTGCAGAAATCACATTGGACCCTCCTCCCAACTGTAGTGCTGGACCCAAA
GGAGACAACATTTATGAATGGAGGTCAACTATATTGGGACCCCCAGGATCTGTCTATGAA
GGAGGGGTGTTCTTTCTTGACATTACCTTTTCACCAGACTATCCGTTTAAACCCCCTAAG
GTTACCTTCCGAACAAGAATCTATCACTGTAATATTAACAGCCAAGGTGTGATCTGTCTG
GACATCTTAAAGGACAACTGGAGTCCGGCTTTAACTATTTCTAAAGTTCTCCTCTCCATC
TGCTCACTTCTTACAGATTGCAACCCTGCTGACCCTCTGGTGGGCAGCATCGCCACACAG
TACATGACCAACAGAGCAGAGCATGACCGGATGGCCAGACAGTGGACCAAGCGGTACGCC
ACATAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
AK057886

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_34_Locus:
3p24.2

# Metabolic_Enzyme_34_SNPs:
rs1552931; rs9848077; rs4858483; rs1498809; rs3111311; rs2132148; rs778501; rs1874913; rs1973400; rs1495135; rs778524; rs952134; rs3111310; rs2047339; rs903519; rs704533; rs778503; rs778522; rs778489; rs778459; rs2036226; rs778466; rs1692619; rs1353322; rs778514; rs1391756; rs2173460; rs6795968; rs4241511; rs7629327; rs4858506; rs6780388; rs4858065; rs6784771; rs9814419; rs1495131; rs1692620; rs12330479; rs2359763; rs11720461; rs903520; rs13064035; rs7612463; rs778520; rs1995175; rs9836135; rs778468; rs1463835; rs1692617; rs6550761; rs1692622; rs6796840; rs1498812; rs2173058; rs4858502; rs875443; rs778500; rs7640458; rs11708160; rs6808488; rs2172828; rs7634565; rs9809176; rs7613969; rs6792370; rs7641764; rs4858062; rs1495133; rs1695203; rs778462; rs9847027; rs2359759; rs7617072; rs2884731; rs6804123; rs9826647; rs11916411; rs9880889; rs4858507; rs778486; rs4858505; rs903518; rs9757330; rs6780787; rs1985664; rs6769173; rs6767599; rs778476; rs1692649; rs1552930; rs6780723; rs3817002; rs7636536; rs11711072; rs6808513; rs4858501; rs2055154; rs11926646; rs778517; rs9869171; rs778527; rs4327331; rs9310716; rs9873329; rs9821419; rs778471; rs6797907; rs7609845; rs9826877; rs7640308; rs1011754; rs6775907; rs9812300; rs6776424; rs7429470; rs778508; rs9758590; rs778494; rs1692646; rs2132145; rs6806387; rs4858504; rs4858484; rs1695183; rs7627380; rs4340647; rs801277; rs6550756; rs9874082; rs778521; rs778470; rs9848331; rs4384902; rs6775891; rs3104243; rs13081371; rs7628949; rs778525; rs6792462; rs9310715; rs1498811; rs778515; rs7636705; rs6763535; rs6805889; rs12715048; rs9853489; rs2173461; rs778460; rs9859651; rs6771206; rs4858077; rs4858074; rs2133331; rs2055307; rs11715035; rs9825835; rs11129112; rs6799234; rs7617659; rs1463836; rs6799861; rs4858496; rs6807390; rs7610906; rs1495134; rs2055156; rs778483; rs1908475; rs12330262; rs2359637; rs13323077; rs778523; rs6775232; rs4858508; rs718331; rs12486880; rs2047340; rs9857217; rs17345745; rs778485; rs778461; rs1695181; rs2359638; rs13063986; rs6802465; rs13074192; rs9819788; rs778496; rs6800822; rs10510537; rs1027379; rs11918529; rs2359766; rs9864908; rs9830388; rs11711630; rs9847958; rs6798328; rs4858499; rs6798153; rs11922172; rs4858069; rs13087234; rs9841308; rs778457; rs1695205; rs778484; rs2201481; rs9856169; rs11914363; rs12636682; rs7631334; rs17012905; rs778472; rs11708040; rs6763329; rs778492; rs716456; rs11922562; rs6550765; rs12634459; rs778469; rs11921580; rs10451986; rs6550760; rs11926494; rs13093140; rs6550759; rs2132144; rs11926217; rs12637722; rs11129114; rs2036042; rs12715046; rs9877182; rs2201484; rs6804201; rs778511; rs9862734; rs6762615; rs7645209; rs6770091; rs778507; rs2173057; rs1692652; rs1695170; rs1995174; rs11129120; rs7641437; rs6550755; rs13098494; rs9825778; rs2132149; rs11712500; rs2359761; rs17013383; rs1695188; rs6797467; rs2359765; rs17401815; rs6771053; rs778499; rs4368441; rs1692612; rs1013460; rs6774214; rs6550751; rs1874235; rs9844723; rs778510; rs10510539; rs17194786; rs17402378; rs778480; rs13321359; rs6788900; rs17013390; rs4858498; rs778475; rs17013457; rs1826847; rs11713090; rs9873317; rs9830742; rs17013152; rs6766166; rs17342904; rs704534; rs9836574; rs11713392; rs778487; rs6550748; rs9865602; rs778516; rs2884787; rs1695171; rs6790185; rs7646028; rs7644666; rs1874503; rs6786085; rs13095887; rs11707450; rs778464; rs9854590; rs4858497; rs17012812; rs7613091; rs9839738; rs2055155; rs1692651; rs4858500; rs9852053; rs13326048; rs4399836; rs9883870; rs923996; rs6790327; rs7627525; rs1692647; rs7646541; rs4858492; rs11712582; rs4642064; rs6792915; rs7613733; rs9816895; rs778493; rs4999998; rs10510538; rs13087861; rs4858513; rs7610971; rs931609; rs9861614; rs11718111; rs6782079; rs9631541; rs778467; rs6550752; rs2101811; rs11715841; rs2132146; rs6784195; rs9873979; rs17012869; rs7638278; rs11715107; rs1496653; rs17342980; rs10510536; rs2132147; rs9840808; rs17012959; rs12629848; rs6763074; rs17012829; rs1390083; rs13062101; rs9849176; rs7617725; rs7635784; rs778497; rs13319402; rs6550758; rs778490; rs6764047; rs11129116; rs9815299; rs7634117; rs9854488; rs17013322; rs9681506; rs12493361; rs9846398; rs9713229; rs4858512; rs7630344; rs7636532; rs6795492; rs9681372; rs9875521; rs6799132; rs17013268; rs11916447; rs13082311; rs4858063; rs716457; rs17013412; rs778473; rs7621680; rs11708176; rs9822422; rs13092830; rs2359755; rs13062360; rs9820922; rs17012861; rs778513; rs6550754; rs9840017; rs9832340; rs13066741; rs17343818; rs17013099; rs9810378; rs12490726; rs7644280; rs17013266; rs9853736; rs17013128; rs17013344; rs7639224; rs12715047; rs12637498; rs4858495; rs17013439; rs9873147; rs12633613; rs13073761; rs4578972; rs5023615; rs13072325; rs9835324; rs17013406; rs9631544; rs1695180; rs1695185; rs9844558; rs9853847; rs2036045; rs6795583; rs1532355; rs9882384; rs9830392; rs9879132; rs12630883; rs17012998; rs12630765; rs3104242; rs13100499; rs17013348; rs4538320; rs13063185; rs9809364; rs17013003; rs13090335; rs13089963; rs17013425; rs17012819; rs17013320; rs4858510; rs12630776; rs17194751; rs1874234; rs17013433; rs4858064; rs7624969; rs1908772; rs9816634; rs1692621; rs9874822; rs9824359; rs13094957; rs9840820; rs4858070; rs17013107; rs9829711; rs12386394; rs12497974; rs1542802; rs17013429; rs17013241; rs11715736; rs9848652; rs17013035; rs6807788; rs9841123; rs999764; rs17013245; rs11717397; rs7614195; rs4858515; rs11719401; rs13060251; rs17013356; rs6802488; rs13060112; rs9821681; rs7632099; rs17013029; rs7642713; rs11129113; rs1692648; rs778465; rs7643705; rs17013125; rs17012972; rs3111309; rs12106681; rs17341838; rs17013329; rs7374774; rs9849679; rs6550746; rs4858491; rs9815921; rs17405137; rs1874502; rs17012927; rs13084870; rs778463; rs13090303; rs7628372; rs778458; rs13087416; rs11708117; rs6767954; rs13087563; rs9875910; rs17012823; rs7632814; rs9845536; rs4289304; rs6776770; rs9881808; rs17012991; rs4581996; rs9845372; rs9845340; rs17013009; rs7648425; rs7374592; rs17401836; rs17012988; rs17081034; rs1908773; rs13095736; rs17012844; rs6780897; rs9843539; rs13067919; rs17012897; rs11920019; rs4293660; rs6800930; rs17013409; rs11712991; rs17013219; rs13076527; rs4325868; rs35024744; rs17403650; rs12496355; rs7649682; rs17012966; rs12635274; rs6795584; rs778491; rs7620266; rs9861803; rs13084327; rs9826089; rs35892300; rs1695192; rs2133330; rs17013116; rs4314113; rs9863465; rs778519; rs9879217; rs13325204; rs7652287; rs13065375; rs1027380; rs9681373; rs778498; rs9836787; rs7430428; rs17013333; rs34504120; rs9854148; rs7614667; rs9845368; rs9828922; rs13314364; rs12715045; rs6550747; rs2055310; rs9831159; rs17013104; rs17411757; rs9862557; rs4858493; rs17013314; rs17012969; rs17013049; rs17012852; rs11708225; rs4293659; rs17013393; rs17013286; rs4858509; rs11129119; rs4858490; rs778506; rs2359760; rs7634699; rs17013023; rs17012834; rs7632520; rs6795043; rs13083654; rs9310718; rs13087238; rs778502; rs13070136; rs4858489; rs17013346; rs778488; rs11712012; rs17013026; rs6799167; rs17013422; rs4334589; rs12638508; rs704535; rs9823684; rs11711549; rs17013223; rs17012943; rs17404982; rs13067514; rs9942016; rs778518; rs17029562; rs1390084; rs17013398; rs12630773; rs6796927; rs17342342; rs17013216; rs12636299; rs7613185; rs13085173; rs4858066; rs4858485; rs9859244; rs9823960; rs13316118; rs11915691; rs12185989; rs3104244; rs1695200; rs2036044; rs2359768; rs9831176; rs6801824; rs9849424; rs7612666; rs778505; rs7636683; rs6778478; rs9990072; rs1692650; rs9848389; rs1007332; rs17013418; rs9819566; rs4241512; rs13096187; rs7651175; rs7643270; rs4574222; rs1695172; rs13063451; rs6762546; rs7627151; rs778526; rs9809246; rs7631705; rs11554196; rs2055157; rs6550745; rs35744259; rs34801964; rs34655379; rs34513914; rs34004449; rs35559434; rs13067453; rs7645478; rs13080824; rs34019786; rs13100986; rs9835256; rs28756798; rs6774590; rs13099586; rs34294210; rs35917039; rs34805565; rs13084953; rs4553929; rs35346188; rs35288442; rs35613382; rs34927279; rs36066660; rs35067315; rs35273607; rs34171096; rs6766072; rs28564523; rs35241601; rs10627218; rs778504; rs35281456; rs34644259; rs35994150; rs34882744; rs28370926; rs2359762; rs34972244; rs4858071; rs13059557; rs34514727; rs1495132; rs5847231; rs2133332; rs34732257; rs13091634; rs34740022; rs3059396; rs13076847; rs11719751; rs10692605; rs34969537; rs36182019; rs11437235; rs34225647; rs6807859; rs34311158; rs36143719; rs34135249; rs9828660; rs34447431; rs34029414; rs13076672; rs10703250; rs11399749; rs13315798; rs13323100; rs34248315; rs4858073; rs34339205; rs11356321; rs34758087; rs5847226; rs6774574; rs34322396; rs10704031; rs778479; rs35156003; rs10630330; rs34619482; rs6779406; rs10562289; rs2201485; rs2036227; rs28631180; rs9841336; rs35339492; rs35209889; rs35096750; rs28367247; rs35405803; rs34067122; rs35314441; rs4488778; rs35236373; rs34004175; rs13064211; rs9810035; rs36150838; rs35320722; rs35169377; rs11397342; rs10704606; rs11425389; rs13100962; rs35603984; rs1908476; rs34258016; rs10559253; rs9878638; rs6765542; rs13065734; rs778495; rs35245309; rs1845901; rs13084987; rs35963028; rs7432884; rs34532662; rs35152860; rs13099582; rs35016740; rs11442997; rs1973399; rs35401876; rs4858075; rs9866739; rs35743404; rs6774928; rs3086989; rs7622784; rs34827773; rs5847239; rs7628003; rs34090967; rs13063813; rs9865397; rs9839409; rs34013055; rs11707094; rs9755356; rs28897461; rs36174165; rs35813986; rs34111484; rs1845899; rs7628135; rs11928344; rs11718082; rs35230557; rs11333992; rs34425323; rs2884789; rs13067287; rs7432467; rs34199335; rs7635882; rs6782723; rs3086987; rs9842035; rs2055308; rs11456761; rs34011862; rs11715598; rs35179250; rs35060672; rs6805391; rs35177750; rs11347961; rs1967172; rs34164749; rs13077333; rs36123979; rs11381346; rs28805096; rs9863419; rs12639123; rs34108997; rs35383024; rs35811102; rs11713457; rs11391548; rs13065646; rs34224623; rs7612874; rs9820931; rs35334059; rs1995173; rs36063633; rs36073188; rs12108063; rs35702053; rs7614926; rs7428484; rs34099028; rs35990123; rs724020; rs35778452; rs12631216; rs13096102; rs35136459; rs11447339; rs34368478; rs35778968; rs13098798; rs12634773; rs36183743; rs35074611; rs34916096; rs7611684; rs13072930; rs7611624; rs35351742; rs35883244; rs34830837; rs13072992; rs35027557; rs13085266; rs11354616; rs12496983; rs34810863; rs4858072; rs9842159; rs35413534; rs34713363; rs778509; rs4858487; rs35408638; rs5847225; rs5847232; rs11705812; rs9882514; rs9815359; rs13083473; rs34983674; rs9857085; rs6774185; rs36140837; rs35266274; rs34371006; rs6790215; rs778481; rs36086737; rs11372402; rs12488422; rs6795813; rs11308326; rs13080837; rs36060079; rs11713613; rs35901544; rs34760619; rs13095960; rs34057009; rs35381236; rs4599240; rs35485787; rs778512; rs13083617; rs35161626; rs35066637; rs34317095; rs34765409; rs34476802; rs9827507; rs13062619; rs13087203; rs983288; rs28835332; rs11916781; rs34755696; rs34262865; rs7611132; rs9855653; rs10578696; rs6788095; rs7639266; rs6769951; rs34080387; rs10610153; rs34954186; rs1617948; rs35190363; rs4858516; rs36021750; rs13090125; rs36093333; rs35657558; rs34459823; rs9757785; rs34928302; rs35420157; rs35817947; rs35063383; rs35021696; rs35907941; rs11359887; rs9866889; rs1532356; rs875442; rs34549973; rs3087043; rs4399835; rs1498813; rs34880366; rs35928592; rs35028631; rs13064903; rs34138117; rs10662592; rs9874519; rs13095737; rs11384608; rs34843352; rs36173426; rs34275104; rs36044544; rs36041959; rs13066171; rs9883963; rs35218978; rs36124326; rs5847233; rs6778020; rs2055309; rs35988401; rs4858068; rs35121170; rs13093554; rs35326512; rs11445285; rs11360897; rs36132862; rs6774454; rs9834737; rs2088129; rs9829336; rs13076699; rs34439066; rs11924465; rs9829861; rs1498810; rs34296828; rs36183485; rs4025924; rs34161839; rs28597758; rs34708529; rs6774587; rs11357167; rs34356234; rs4524226; rs7637485; rs13083439; rs4858511; rs13100605; rs11392947; rs9809298; rs12638194; rs35587093; rs35455231; rs778478; rs36037043; rs34317788; rs34873925; rs11320868; rs13324677; rs35156717; rs9810575; rs4361229; rs34284238; rs9821101; rs13078970; rs11333459; rs35038477; rs2220886; rs6773311; rs10717256; rs7618910; rs1994953; rs5847228; rs34255787; rs13068781; rs11457219; rs28412415; rs34410150; rs7612812; rs35282362; rs35360888; rs35067578; rs28408542; rs34541947; rs35325265; rs923995; rs13319311; rs4858488; rs34214070; rs13064776; rs34208918; rs13075300; rs13096458; rs13069028; rs9822891; rs13067459; rs1553131; rs11429585; rs9830853; rs35587590; rs34064548; rs11352255; rs13099381; rs4858078; rs7622178; rs13059155; rs13067927; rs35439686; rs28871023; rs13080401; rs13080261; rs35799553; rs13067463; rs5847236; rs12488524; rs34883078; rs2201482; rs11708887; rs13067292; rs9829577; rs36160278; rs34259979; rs6768277; rs34141165; rs6804376; rs2036043; rs10620901; rs35712816; rs34578427; rs2047338; rs7634494; rs10534830; rs34710747; rs35305944; rs9845888; rs35098118; rs13097879; rs13323350; rs13076490; rs41380744; rs13072903; rs9755698; rs34495480; rs34370439; rs34474714; rs28641973; rs34968174; rs35194124; rs3086984; rs9840015; rs7646505; rs11381775; rs13063183; rs34134134; rs5847234; rs35708850; rs9837894; rs35442948; rs34443476; rs36136020; rs11328464; rs2201483; rs9832647; rs7622913; rs35497505; rs13076412; rs35833677; rs35966355; rs13088756; rs35443771; rs12054273; rs34377610; rs13073593; rs9840130; rs2036229; rs778482; rs36118618; rs4476456; rs35513866; rs34532882; rs13073524; rs12638406; rs11406000; rs9840140; rs34899111; rs6781388; rs7653868; rs11712656; rs35700342; rs1692645; rs4327332; rs11352500; rs6801946; rs35038414; rs778477; rs4025942; rs12485849; rs17402608; rs34928966; rs35287004; rs35902312; rs35903137; rs13067467; rs35323293; rs34376193; rs11433089; rs35513038; rs34051258; rs13067920; rs34825213; rs34680912; rs34525850; rs2359754; rs1695182; rs34047841; rs34305655; rs35788274; rs28582435; rs13067297; rs28842243; rs34584255; rs35513677; rs9811442; rs34564428; rs36016917; rs11433498; rs1692638; rs9841518; rs35403338; rs13100586; rs5019982; rs35538160; rs6769959; rs34011881; rs35778846; rs13065739; rs34474308; rs34962134; rs28656359; rs35220572; rs12638196; rs7614862; rs4513393; rs28787705; rs34644980; rs5847230; rs34528386; rs34646795; rs34830958; rs34258354; rs36004369; rs28567933; rs34896901; rs35795978; rs36082634; rs6765562; rs10700726; rs35105861; rs35084497; rs34775715; rs35614844; rs35347265; rs13071171; rs35003468; rs34334389; rs34087203; rs35449120; rs13085800; rs34528594; rs9841944; rs10428163; rs36173746; rs35402533; rs9868679; rs35163126; rs10662118; rs6765758; rs34743949; rs13086699; rs13067621; rs35776486; rs5847229; rs34362283; rs4558694; rs7429584; rs35869522; rs1695191; rs12490674; rs34036254; rs35240920; rs10701454; rs7638405; rs11349385; rs35762193; rs34536134; rs35404470; rs10212447; rs34239585; rs41400550; rs11401214; rs9867046; rs13088503; rs36005105; rs13101148; rs6764347; rs36123653; rs11456309; rs13067462; rs11299451; rs9842014; rs13073294; rs35322237; rs35802594; rs11721206; rs4072269; rs4361228; rs2088581; rs4858503; rs9845667; rs12632993; rs34367049; rs1054048; rs5847237; rs13076698; rs809640; rs13091625; rs9755696; rs34919006; rs13084967; rs12498004; rs5847235; rs11363428; rs2017065; rs9873929; rs35102034; rs35404820; rs4568058; rs35806683; rs7614479; rs35458447; rs11274063; rs34402532; rs5847240; rs4858076; rs36174845; rs11369768; rs2036228; rs35055753; rs12488059; rs1692614; rs34421575; rs7624174; rs10704575; rs13090633; rs5847238; rs12489408; rs11706072; rs10663571; rs10718748; rs13089479; rs35755640; rs13084250; rs35649850; rs34743793; rs9826103; rs1845900; rs4635650; rs4405859; rs17013336; rs4318497; rs35922435; rs11276620; rs1695197; rs35961001; rs11348019; rs10662177; rs35059447; rs35975795; rs34120479; rs34970044; rs11391624; rs13326380; rs35054154; rs9822244; rs35763885; rs9862673; rs35572661; rs13080692; rs10682310; rs13059775; rs34916962; rs10575820; rs778474; rs12632777; rs28548892; rs11422553; rs11456235; rs35072406; rs7628132; rs9870906; rs34804976; rs11705847; rs35630756; rs9861406; rs35982877; rs35530129; rs6550757; rs35954718; rs35646138; rs4383456; rs34229526; rs12637703; rs35902301; rs7429529; rs34894979; rs13073916; rs35294789; rs2172827; rs28889973; rs13070865; rs6769167; rs13096103; rs35306746; rs35352848; rs11915870; rs35200912; rs35093619; rs34599085; rs6786467; rs34672958; rs36078559; rs36079547; rs12487364; rs34139654; rs35155584; rs35890221; rs34304041; rs10049448; rs1032499; rs1032500; rs1032501; rs10440129; rs11706875; rs11717508; rs11914576; rs11917849; rs11919065; rs13325299; rs1495130; rs17012800; rs2291720; rs34970845; rs4324429; rs4383458; rs4456808; rs4484143; rs6550767; rs7431560; rs7624207; rs7627325; rs7648443; rs7649176; rs7651893; rs9847733; rs9859515; rs9859950; rs9881332

# Metabolic_Enzyme_34_General_References:
Not Available

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
5857

# Metabolic_Enzyme_35_Name:
Adenylosuccinate lyase

# Metabolic_Enzyme_35_Synonyms:
Adenylosuccinase; ASL; ASASE

# Metabolic_Enzyme_35_Gene_Name:
ADSL

# Metabolic_Enzyme_35_Protein_Sequence:
>Adenylosuccinate lyase
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE
QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD
LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC
MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG
QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR
SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE
GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD
NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA
ELCL

# Metabolic_Enzyme_35_Number_of_Residues:
484

# Metabolic_Enzyme_35_Molecular_Weight:
54890

# Metabolic_Enzyme_35_Theoretical_pI:
7.12

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  amidine-lyase activity
Function:  adenylosuccinate lyase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine ribonucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_35_Specific_Function:
6-N-(1,2-dicarboxyethyl)AMP = fumarate + AMP

# Metabolic_Enzyme_35_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_35_Reaction:
(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP; (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 4.3.2.2

# Metabolic_Enzyme_35_GenBank_ID_Protein:
28904

# Metabolic_Enzyme_35_SwissProt_ID:
PUR8_HUMAN (P30566)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
ADSL

# Metabolic_Enzyme_35_Geneatlas_id:
ADSL

# Metabolic_Enzyme_35_hgnc_id:
HGNC:291

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Not Available

# Metabolic_Enzyme_35_Gene_Sequence:
>1455 bp
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGC
TATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGG
CAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAA
CAAATCCAGGAGATGAAATCAAACCTGGAGAACATAGACTTCAAGATGGCAGCTGAGGAA
GAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACACATTTGGCCACTGCTGTCCA
AAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGACAATACTGAC
TTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTC
CAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGC
ATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAG
CAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGAGAGCTTTCATCATCACAGGG
CAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGT
TCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGT
TTGGCCGAGGCATTTCTTACCGCAGATACTATATTGAATACGCTGCAGAACATTTCTGAA
GGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCAT
GAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTC
TTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCA
GAATTATGTCTGTAG

# Metabolic_Enzyme_35_GenBank_ID_Gene:
X65867

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_35_Locus:
22q13.1|22q13.2

# Metabolic_Enzyme_35_SNPs:
rs2068470; rs3788578; rs3788579; rs3788577; rs9611321; rs8135371; rs7291418; rs17001846; rs10854729; rs11913275; rs2280790; rs2075764; rs12160297; rs5757922; rs17001863; rs17001848; rs17001857; rs4321458; rs2006965; rs909669; rs12484610; rs5757921; rs8192461; rs11089991; rs8192457; rs34396910; rs8192454; rs2735668; rs11703124; rs8192453; rs8192458; rs2743718; rs17001854; rs5995848; rs2743725; rs2735660; rs2735669; rs34476033; rs2735672; rs4820411; rs2743716; rs6001886; rs35043528; rs35572733; rs5995847; rs2743723; rs2735665; rs10427931; rs11089990; rs2743721; rs12170384; rs2743728; rs2743719; rs8192455; rs2735667; rs8192460; rs1882824; rs5757924; rs36099663; rs2735663; rs2735673; rs2743717; rs10427911; rs28699192; rs2743726; rs3830737; rs2743724; rs7285719; rs6001887; rs8192452; rs28642715; rs9611322; rs5750935; rs2735664; rs2735666; rs8192459; rs11431892; rs9611323; rs1882823; rs35553188; rs8142978; rs2743729; rs2743722; rs5757923; rs2735661; rs8192456; rs35401769; rs2743727; rs17001850; rs2743720; rs35128658; rs3044501; rs2743731; rs742139; rs2006961; rs909205; rs5995846; rs9607708; rs5757920; rs2743714; rs751367; rs5995845; rs5757918; rs16985898; rs9611320; rs2743732; rs35992774; rs909204; rs11320845; rs2743730; rs2743715; rs10650685; rs5757919; rs2743713; rs12484697; rs4619722; rs5995844; rs6001883; rs6001888; rs9611310; rs9611311; rs9611312; rs9611314; rs9611316; rs9611318; rs9623170

# Metabolic_Enzyme_35_General_References:
10888601; 10591208; 1302001; 9545543; 10090474; 10958654; 12368987

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
5858

# Metabolic_Enzyme_36_Name:
Adenylate kinase isoenzyme 4, mitochondrial

# Metabolic_Enzyme_36_Synonyms:
Adenylate kinase 3-like 1; ATP-AMP transphosphorylase

# Metabolic_Enzyme_36_Gene_Name:
AK3L1

# Metabolic_Enzyme_36_Protein_Sequence:
>Adenylate kinase isoenzyme 4, mitochondrial
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEK
SLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLK
DRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKP
VIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY

# Metabolic_Enzyme_36_Number_of_Residues:
223

# Metabolic_Enzyme_36_Molecular_Weight:
25268

# Metabolic_Enzyme_36_Theoretical_pI:
8.66

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  adenylate kinase activity
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_36_Specific_Function:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_36_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_36_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00406:ADK;
PF05191:ADK_lid

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_36_GenBank_ID_Protein:
28577

# Metabolic_Enzyme_36_SwissProt_ID:
KAD4_HUMAN (P27144)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
AK3L1

# Metabolic_Enzyme_36_Geneatlas_id:
AK3L1

# Metabolic_Enzyme_36_hgnc_id:
HGNC:363

# Metabolic_Enzyme_36_PDB_ID:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_36_Gene_Sequence:
>672 bp
ATGGCTTCCAAACTCCTGCGCGCGGTCATCCTCGGGCCGCCCGGCTCGGGCAAGGGCACC
GTGTGCCAGAGGATCGCCCAGAACTTTGGTCTCCAGCATCTCTCCAGCGGCCACTTCTTG
CGGGAGAACATCAAGGCCAGCACCGAAGTTGGTGAGATGGCAAAGCAGTATATAGAGAAA
AGTCTTTTGGTTCCAGACCATGTGATCACACGCCTAATGATGTCCGAGTTGGAGAACAGG
CGTGGACAGCACTGGCTCCTTGATGGTTTTCCTAGGACATTAGGACAAGCCGAAGCCCTG
GACAAAATCTGTGAAGTGGATCTAGTGATCAGTTTGAATATTCCATTTGAAACACTTAAA
GATCGTCTCAGCCGCCGTTGGATTCACCCTCCTAGCGGAAGGGTATATAACCTGGACTTC
AATCCACCTCATGTACATGGTATTGATGACGTCACTGGTGAACCGTTAGTCCAGCAGGAG
GATGATAAACCCGAAGCAGTTGCTGCCAGGCTAAGACAGTACAAAGACGTGGCAAAGCCA
GTCATTGAATTATACAAGAGCCGAGGAGTGCTCCACCAATTTTCCGGAACGGAGACGAAC
AAAATCTGGCCCTACGTTTACACACTTTTCTCAAACAAGATCACACCTATTCAGTCCAAA
GAAGCATATTGA

# Metabolic_Enzyme_36_GenBank_ID_Gene:
X60673

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_36_Locus:
1p31.3

# Metabolic_Enzyme_36_SNPs:
rs9092; rs2375754; rs4916021; rs2889183; rs4915681; rs12410079; rs12089221; rs12068872; rs10583751; rs5029884; rs35775264; rs10047101; rs10465849; rs10465850; rs1072864; rs10749750; rs10789170; rs10789171; rs10789175; rs10789176; rs10889523; rs10889525; rs10889527; rs10889529; rs1109374; rs11208596; rs11208599; rs11208604; rs11208605; rs11208607; rs11208609; rs11208610; rs11208611; rs1122651; rs1125091; rs11579215; rs11581070; rs11581072; rs11803130; rs11807827; rs12022787; rs12030227; rs12048066; rs12060525; rs12074520; rs12088806; rs12091763; rs12091953; rs12093622; rs12094960; rs12119363; rs12124886; rs12133650; rs12401887; rs12403808; rs12404018; rs12404708; rs12409392; rs12561779; rs12563060; rs12565315; rs12568459; rs12747074; rs1336472; rs1336474; rs13374371; rs1539551; rs1573168; rs17127364; rs17127378; rs17127422; rs17400019; rs1855981; rs1855982; rs1889925; rs1889926; rs1891674; rs2051092; rs2226173; rs2375596; rs2375597; rs2375598; rs2889130; rs34248479; rs35832978; rs3934817; rs4291532; rs4372299; rs4453083; rs4511159; rs4915683; rs4915684; rs4915685; rs4916026; rs4916030; rs4916031; rs4916032; rs6588125; rs6588126; rs6588127; rs6656147; rs6677191; rs6677316; rs6680983; rs6689998; rs6690851; rs6691933; rs6699614; rs6702163; rs6702993; rs6704305; rs7416515; rs7511787; rs7521374; rs7526688; rs7529834; rs7545094; rs7547221; rs7548127; rs7550324; rs7553495; rs955255

# Metabolic_Enzyme_36_General_References:
1639383

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
5236

# Metabolic_Enzyme_37_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_37_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_37_Gene_Name:
NT5M

# Metabolic_Enzyme_37_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_37_Number_of_Residues:
228

# Metabolic_Enzyme_37_Molecular_Weight:
25862

# Metabolic_Enzyme_37_Theoretical_pI:
8.12

# Metabolic_Enzyme_37_GO_Classification:
Not Available

# Metabolic_Enzyme_37_General_Function:
Not Available

# Metabolic_Enzyme_37_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_37_Pathway:
Not Available

# Metabolic_Enzyme_37_Reaction:
Not Available

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_37_Signals:
1-15

# Metabolic_Enzyme_37_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_37_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_37_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
NT5M

# Metabolic_Enzyme_37_Geneatlas_id:
NT5M

# Metabolic_Enzyme_37_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_37_PDB_ID:
1Q92

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_37_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_37_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_37_Locus:
17p11.2

# Metabolic_Enzyme_37_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_37_General_References:
10899995; 12352955

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
5859

# Metabolic_Enzyme_38_Name:
Ubiquitin-conjugating enzyme E2 D2

# Metabolic_Enzyme_38_Synonyms:
Ubiquitin-protein ligase D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2-17 kDa 2; E2(17KB 2

# Metabolic_Enzyme_38_Gene_Name:
UBE2D2

# Metabolic_Enzyme_38_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D2
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDREKYNRIAREWTQKYAM

# Metabolic_Enzyme_38_Number_of_Residues:
147

# Metabolic_Enzyme_38_Molecular_Weight:
16735

# Metabolic_Enzyme_38_Theoretical_pI:
7.96

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_38_General_Function:
Not Available

# Metabolic_Enzyme_38_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_38_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_38_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_38_GenBank_ID_Protein:
1145689

# Metabolic_Enzyme_38_SwissProt_ID:
UB2D2_HUMAN (P62837)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
UBE2D2

# Metabolic_Enzyme_38_Geneatlas_id:
UBE2D2

# Metabolic_Enzyme_38_hgnc_id:
HGNC:12475

# Metabolic_Enzyme_38_PDB_ID:
1UR6

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Not Available

# Metabolic_Enzyme_38_Gene_Sequence:
>444 bp
ATGGCTCTGAAGAGAATCCACAAGGAATTGAATGATCTGGCACGGGACCCTCCAGCACAG
TGTTCAGCAGGTCCTGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA
AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTTGATATTCTACGATCACAGTGGTCTCCAGCACTAACTATTTCA
AAAGTACTCTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG
CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA
TGGACTCAGAAGTATGCGATGTAA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
U39317

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_38_Locus:
5q31.2

# Metabolic_Enzyme_38_SNPs:
rs769052; rs355148; rs261534; rs261532; rs355163; rs355161; rs11742182; rs431184; rs355151; rs261530; rs355147; rs11739735; rs355160; rs11745986; rs436308; rs355159; rs10080073; rs13160670; rs432021; rs401870; rs191642; rs355162; rs10041009; rs355158; rs6863230; rs165179; rs356428; rs356427; rs7735780; rs173335; rs403583; rs440662; rs355157; rs446588; rs12522684; rs356426; rs12516628; rs35329113; rs11745287; rs13173105; rs11446242; rs11418234; rs13359150; rs261531; rs34077929; rs34069884; rs35426398; rs35539143; rs166363; rs34197355; rs10070662; rs35586007; rs28829083; rs34181052; rs34848313; rs13340360; rs35460912; rs10051828; rs861110; rs36027909; rs173313; rs355164; rs3052716; rs1053439; rs5871700; rs11425354; rs34582513; rs35656160; rs34558950; rs13187063; rs11399868; rs11748952; rs13171900; rs4912705; rs10642044; rs11960270; rs34037453; rs34066792; rs13360691; rs34697798; rs5871699; rs33998713; rs34262724; rs261533; rs400752; rs35460807; rs35791838; rs34654005; rs13156781; rs34508985; rs34864079; rs35070538; rs10576440; rs35250928; rs34719091; rs35008393; rs10241; rs149308; rs11746982; rs406234; rs13161515; rs34999200; rs11557558; rs10069891; rs35023106; rs10077827; rs34444899; rs4044316; rs824159; rs11167511; rs1132734; rs187780; rs34295586; rs403719; rs10642043; rs35529886; rs169015; rs11957802; rs187144; rs10050552; rs4519969; rs34260351; rs6863764; rs430284; rs34313106; rs11341390; rs10621546; rs165180; rs28666809; rs12518658; rs7734338; rs10065372; rs12520710; rs36025157; rs9324839; rs191643; rs28606386; rs10068179; rs34610126; rs35630520; rs355154; rs622355; rs36010124; rs41391051; rs28402246; rs677275; rs41393145; rs638202; rs3777111; rs34693140; rs355153; rs13159515; rs28492801; rs10056652; rs28477768; rs34687149; rs12653982; rs3777110; rs4044317; rs591830; rs355152; rs655674; rs34199267; rs355156; rs355146; rs7729523; rs13361425; rs9324838; rs12652179; rs28622416; rs355155; rs12513420; rs7442849; rs181494; rs11421613; rs34150521; rs12517275; rs13178050; rs13357137; rs261537; rs356456; rs356458; rs356459; rs356460; rs356461; rs356462; rs356463; rs4912730; rs629831; rs678176; rs7448830

# Metabolic_Enzyme_38_General_References:
8530467; 7724550; 10918611

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
5860

# Metabolic_Enzyme_39_Name:
DNA ligase 4

# Metabolic_Enzyme_39_Synonyms:
DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4

# Metabolic_Enzyme_39_Gene_Name:
LIG4

# Metabolic_Enzyme_39_Protein_Sequence:
>DNA ligase 4
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI

# Metabolic_Enzyme_39_Number_of_Residues:
911

# Metabolic_Enzyme_39_Molecular_Weight:
103972

# Metabolic_Enzyme_39_Theoretical_pI:
8.04

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  cell
Component:  intracellular

# Metabolic_Enzyme_39_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_39_Specific_Function:
Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA- dependent protein kinase complex DNA-PK to these DNA ends

# Metabolic_Enzyme_39_Pathway:
Not Available

# Metabolic_Enzyme_39_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF00533:BRCT;
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N

# Metabolic_Enzyme_39_Signals:
None

# Metabolic_Enzyme_39_Transmembrane_Regions:
None

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_39_GenBank_ID_Protein:
860937

# Metabolic_Enzyme_39_SwissProt_ID:
DNL4_HUMAN (P49917)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
LIG4

# Metabolic_Enzyme_39_Geneatlas_id:
LIG4

# Metabolic_Enzyme_39_hgnc_id:
HGNC:6601

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_39_Gene_Sequence:
>2535 bp
ATGAGACTAATTCTTCCTCAGCTAGAAAGAGAGAGAATGGCCTATGGAATTAAAGAAACT
ATGCTTGCTAAGCTTTATATTGAGTTGCTTAATTTACCTAGAGATGGAAAAGATGCCCTC
AAACTTTTAAACTACAGAACACCCACTGGAACTCATGGAGATGCTGGAGACTTTGCAATG
ATTGCATATTTTGTGTTGAAGCCAAGATGTTTACAGAAAGGAAGTTTAACCATACAGCAA
GTAAACGACCTTTTAGACTCAATTGCCAGCAATAATTCTGCTAAAAGAAAAGACCTAATA
AAAAAGAGCCTTCTTCAACTTATAACTCAGAGTTCAGCACTTGAGCAAAAGTGGCTTATA
CGGATGATCATAAAGGATTTAAAGCTTGGTGTTAGTCAGCAAACTATCTTTTCTGTTTTT
CATAATGATGCTGCTGAGTTGCATAATGTCACTACAGATCTGGAAAAAGTCTGTAGGCAA
CTGCATGATCCTTCTGTAGGACTCAGTGATATTTCTATCACTTTATTTTCTGCATCAAAA
CCAATGCTAGCTGCTATTGCAGATATTGAGCACATTGAGAAGGATATGAAACATCAGAGT
TTCTACATAGAAACCAAGCTAGATGGTGAACGTATGCAAATGCACAAAGATGGAGATGTA
TATAAATACTTCTCTCGAAATGGATATAACTACACTGATCAGTTTGGTGCTTCTCCTACT
GAAGGTTCTCTTACCCCATTCATTCATAATGCATTCAAAGCAGATATACAAATCTGTATT
CTTGATGGTGAGATGATGGCCTATAATCCTAATACACAAACTTTCATGCAAAAGGGAACT
AAGTTTGATATTAAAAGAATGGTAGAGGATTCTGATCTGCAAACTTGTTATTGTGTTTTT
GATGTATTGATGGTTAATAATAAAAAGCTAGGGCATGAGACTCTGAGAAAGAGGTATGAG
ATTCTTAGTAGTATTTTTACACCAATTCCAGGTAGAATAGAAATAGTGCAGAAAACACAA
GCTCATACTAAGAATGAAGTAATTGATGCATTGAATGAAGCAATAGATAAAAGAGAAGAG
GGAATTATGGTAAAACAACCTCTATCCATCTACAAGCCAGACAAAAGAGGTGAAGGGTGG
TTAAAAATTAAACCAGAGTATGTCAGTGGACTAATGGATGAATTGGACATTTTAATTGTT
GGAGGATATTGGGGTAAAGGATCACGGGGTGGAATGATGTCTCATTTTCTGTGTGCAGTA
GCAGAGAAGCCCCCTCCTGGTGAGAAGCCATCTGTGTTTCATACTCTCTCTCGTGTTGGG
TCTGGCTGCACCATGAAAGAACTGTATGATCTGGGTTTGAAATTGGCCAAGTATTGGAAG
CCTTTTCATAGAAAAGCTCCACCAAGCAGCATTTTATGTGGAACAGAGAAGCCAGAAGTA
TACATTGAACCTTGTAATTCTGTCATTGTTCAGATTAAAGCAGCAGAGATCGTACCCAGT
GATATGTATAAAACTGGCTGCACCTTGCGTTTTCCACGAATTGAAAAGATAAGAGATGAC
AAGGAGTGGCATGAGTGCATGACCCTGGACGACCTAGAACAACTTAGGGGGAAGGCATCT
GGTAAGCTCGCATCTAAACACCTTTATATAGGTGGTGATGATGAACCACAAGAAAAAAAG
CGGAAAGCTGCCCCAAAGATGAAGAAAGTTATTGGAATTATTGAGCACTTAAAAGCACCT
AACCTTACTAACGTTAACAAAATTTCTAATATATTTGAAGATGTAGAGTTTTGTGTTATG
AGTGGAACAGATAGCCAGCCAAAGCCTGACCTGGAGAACAGAATTGCAGAATTTGGTGGT
TATATAGTACAAAATCCAGGCCCAGACACGTACTGTGTAATTGCAGGGTCTGAGAACATC
AGAGTGAAAAACATAATTTTGTCAAATAAACATGATGTTGTCAAGCCTGCATGGCTTTTA
GAATGTTTTAAGACCAAAAGCTTTGTACCATGGCAGCCTCGCTTTATGATTCATATGTGC
CCATCAACCAAAGAACATTTTGCCCGTGAATATGATTGCTATGGTGATAGTTATTTCATT
GATACAGACTTGAACCAACTGAAGGAAGTATTCTCAGGAATTAAAAATTCTAACGAGCAG
ACTCCTGAAGAAATGGCTTCTCTGATTGCTGATTTAGAATATCGGTATTCCTGGGATTGC
TCTCCTCTCAGTATGTTTCGACGCCACACCGTTTATTTGGACTCGTATGCTGTTATTAAT
GACCTGAGTACCAAAAATGAGGGGACAAGGTTAGCTATTAAAGCCTTGGAGCTTCGGTTT
CATGGAGCAAAAGTAGTTTCTTGTTTAGCTGAGGGAGTGTCTCATGTAATAATTGGGGAA
GATCATAGTCGTGTTGCAGATTTTAAAGCTTTTAGAAGAACTTTTAAGAGAAAGTTTAAA
ATCCTAAAAGAAAGTTGGGTAACTGATTCAATAGACAAGTGTGAATTACAAGAAGAAAAC
CAGTATTTGATTTAA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
X83441

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:13

# Metabolic_Enzyme_39_Locus:
13q33-q34

# Metabolic_Enzyme_39_SNPs:
rs1805388; rs2232642; rs1805389; rs2232641; rs2232636; rs2232638; rs1805386; rs2232639; rs3093764; rs3093772; rs3093748; rs10131; rs3093740; rs3093747; rs3093758; rs1805387; rs3093739; rs3093743; rs4987182; rs3093769; rs3093741; rs3093759; rs1805385; rs2232643; rs3093744; rs1805383; rs3093742; rs3093768; rs3093770; rs3093751; rs2232644; rs3093756; rs3093745; rs3093767; rs1805384; rs3093755; rs3093753; rs3093762; rs3093746; rs3093750; rs3093761; rs3093757; rs1151403; rs1151402; rs3093773; rs3093774; rs3093775; rs9587529; rs1151404; rs2776776; rs2232640; rs3093763; rs3093765; rs35469724; rs3742212; rs35874133; rs3093766; rs2232637; rs3093754; rs3093752; rs34383855; rs9706945; rs12875874; rs3093749; rs35399798; rs3093760; rs3093771; rs12875994; rs41308566; rs41315050; rs35417825; rs9520822; rs12016880; rs36219967; rs34562001; rs12866542; rs36219968; rs12866214; rs35961345; rs36219969; rs1105451; rs1151400; rs1151401; rs1151405; rs11620361; rs11841388; rs12428162; rs12428765; rs12429577; rs12429583; rs12430753; rs12874628; rs1473792; rs1555902; rs17497319; rs1853976; rs34214453; rs3809347; rs4772958; rs7322498; rs868284; rs915047; rs928550; rs9514825; rs9520820; rs9520823; rs9559281; rs9587525; rs9587526; rs9587527; rs9587528

# Metabolic_Enzyme_39_General_References:
7760816; 8798671; 9809069; 12547193; 10395545; 11349135; 11779494

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
5861

# Metabolic_Enzyme_40_Name:
Ubiquitin-conjugating enzyme E2 H

# Metabolic_Enzyme_40_Synonyms:
Ubiquitin-protein ligase H; Ubiquitin carrier protein H; UbcH2; E2-20K

# Metabolic_Enzyme_40_Gene_Name:
UBE2H

# Metabolic_Enzyme_40_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
HMSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPD
KYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPI
DPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQ
DMEL

# Metabolic_Enzyme_40_Number_of_Residues:
183

# Metabolic_Enzyme_40_Molecular_Weight:
20655

# Metabolic_Enzyme_40_Theoretical_pI:
4.29

# Metabolic_Enzyme_40_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_40_General_Function:
Not Available

# Metabolic_Enzyme_40_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A

# Metabolic_Enzyme_40_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_40_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_40_Signals:
None

# Metabolic_Enzyme_40_Transmembrane_Regions:
None

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_40_GenBank_ID_Protein:
474827

# Metabolic_Enzyme_40_SwissProt_ID:
UBE2H_HUMAN (P62256)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
UBE2H

# Metabolic_Enzyme_40_Geneatlas_id:
UBE2H

# Metabolic_Enzyme_40_hgnc_id:
HGNC:12484

# Metabolic_Enzyme_40_PDB_ID:
1YH6

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Not Available

# Metabolic_Enzyme_40_Gene_Sequence:
>552 bp
ATGTCATCTCCCAGTCCGGGCAAGAGGCGGATGGACACGGACGTGGTCAAGCTCATCGAG
AGTAAACATGAGGTTACGATCCTGGGAGGACTTAATGAATTTGTAGTGAAGTTTTATGGA
CCACAAGGAACACCATATGAAGGCGGAGTATGGAAAGTTAGAGTGGACCTACCTGATAAA
TACCCTTTCAAATCTCCATCTATAGGATTCATGAATAAAATTTTCCATCCCAACATTGAT
GAAGCGTCAGGAACTGTGTGTCTAGATGTAATTAATCAAACTTGGACAGCTCTCTATGAT
CTTACCAATATATTTGAGTCCTTCCTGCCTCAGTTATTGGCCTATCCTAACCCCATAGAT
CCTCTCAATGGTGACGCTGCAGCCATGTACCTCCACCGACCAGAAGAATACAAGCAGAAA
ATTAAAGAGTACATCCAGAAATACGCCACGGAGGAGGCGCTGAAAGAACAGGAAGAGGGT
ACCGGGGACAGCTCATCGGAGAGCTCTATGTCTGACTTTTCCGAAGATGAGGCCCAGGAT
ATGGAGTTGTAG

# Metabolic_Enzyme_40_GenBank_ID_Gene:
Z29328

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_40_Locus:
7q32

# Metabolic_Enzyme_40_SNPs:
rs12539800; rs1046691; rs7639; rs1045897; rs2727500; rs1471876; rs2708637; rs1464973; rs1486831; rs2727487; rs12538787; rs2693741; rs7783328; rs718925; rs12537150; rs10215972; rs9656387; rs3807120; rs1471877; rs2727464; rs1725078; rs2727495; rs6467267; rs923231; rs3807121; rs12534043; rs12534061; rs12531936; rs2727476; rs6979056; rs12536424; rs2280680; rs2727499; rs12537660; rs3817530; rs3736214; rs3807118; rs12537576; rs12540517; rs17559596; rs2708653; rs17558874; rs10500121; rs12536978; rs2727480; rs12531622; rs2631601; rs12535347; rs2693747; rs2693722; rs10268712; rs7801603; rs12537782; rs2727507; rs12532959; rs10273782; rs2693721; rs11760945; rs2727492; rs12540541; rs1723728; rs1464972; rs12533528; rs12533033; rs7803795; rs1725077; rs2727482; rs2693740; rs2727479; rs10246707; rs1464971; rs12540479; rs12533290; rs17639187; rs6960765; rs7789191; rs12665878; rs17639487; rs2727461; rs2631603; rs10216153; rs2708649; rs10261367; rs16873739; rs2708651; rs2631602; rs11765073; rs17559441; rs10216157; rs17559301; rs7805042; rs7777157; rs7806091; rs2631606; rs2727490; rs9656386; rs7805384; rs2727494; rs2255639; rs7788714; rs10265243; rs1471874; rs10253233; rs7805717; rs3807119; rs6962745; rs1725079; rs7809265; rs2466981; rs17162295; rs11978225; rs2727497; rs10227968; rs2727506; rs13242512; rs1471875; rs7805045; rs2727458; rs12533464; rs7808987; rs1405239; rs12539145; rs7805736; rs2727477; rs2727460; rs12532612; rs17162123; rs2727466; rs2402980; rs2727488; rs12537336; rs12537604; rs17162050; rs7783474; rs2693724; rs7805552; rs6959075; rs3800561; rs12530557; rs2708641; rs7788461; rs718926; rs10249037; rs2631604; rs3807122; rs17162136; rs10240142; rs4731636; rs12534320; rs2727467; rs12535722; rs12535728; rs6963861; rs6964187; rs2727501; rs8485; rs1045896; rs1062977; rs11548945; rs11548944; rs34456570; rs17162882; rs8673; rs10486; rs1045894; rs34965300; rs1965568; rs34568839; rs7808364; rs35898647; rs35356388; rs2727489; rs11356893; rs34859314; rs34926272; rs11760768; rs35884790; rs5887456; rs36003769; rs35482241; rs11299056; rs17559568; rs34648726; rs34034618; rs28473687; rs11765213; rs11773785; rs2727485; rs35586367; rs4728180; rs10271802; rs2727475; rs1464970; rs6970225; rs35239982; rs2727462; rs11422674; rs11421202; rs5887452; rs34547874; rs6952373; rs34057112; rs2727481; rs34362444; rs7793305; rs35048152; rs28539366; rs3043708; rs2631607; rs34594241; rs1965567; rs34695655; rs7782413; rs13241892; rs35945331; rs2708648; rs2693725; rs13238461; rs3807115; rs1526323; rs35463166; rs2727478; rs34198937; rs2727484; rs10642301; rs5887455; rs2727498; rs10677960; rs11438278; rs35429139; rs11297139; rs35140578; rs11430559; rs35596978; rs13241340; rs34089543; rs13221952; rs4731638; rs35996659; rs2693742; rs11297393; rs36093184; rs34279042; rs34199011; rs7804954; rs34673682; rs2727463; rs7790079; rs1486830; rs1132932; rs35447763; rs13240058; rs35723763; rs3839653; rs12665979; rs4256541; rs34001143; rs10525494; rs34482065; rs34072997; rs34488741; rs2037720; rs34582657; rs5887451; rs35577888; rs5887454; rs34087329; rs34093190; rs1057928; rs2631605; rs11347186; rs13234123; rs35265871; rs2708642; rs35074582; rs34403102; rs7778053; rs11308308; rs28510253; rs3891318; rs28604351; rs11430560; rs10275798; rs2693743; rs2708650; rs3891319; rs35963787; rs11448310; rs2692443; rs34490269; rs3840552; rs3832461; rs12533468; rs35964242; rs2727496; rs34297290; rs35207398; rs34930431; rs35916150; rs13228286; rs6962972; rs3807116; rs2693746; rs35189138; rs34941204; rs2727483; rs35167740; rs34227624; rs34182980; rs2727491; rs2727486; rs5028472; rs12535857; rs13238782; rs11405982; rs34262631; rs35326390; rs2464894; rs28444603; rs34571747; rs5887453; rs2727459; rs34701981; rs34412294; rs1723727; rs35043856; rs34258788; rs2693744; rs10239779; rs3886312; rs10243840; rs35268874; rs6957308; rs10261345; rs34767129; rs12539653; rs3043701; rs11766498; rs2466987; rs35874993; rs10637757; rs34045760; rs11291694; rs7789336; rs2727493; rs34675108; rs13241012; rs35808448; rs34454670; rs11347187; rs35593803; rs4612285; rs10545721; rs10242002; rs35021353; rs34924795; rs11269421; rs6964169; rs2693723; rs3840551; rs35710137; rs11334941; rs35716732; rs34730487; rs35097197; rs11401650; rs2692442; rs1063296; rs34351192; rs35008319; rs3734927; rs13312322; rs34782630; rs3832460; rs10678531; rs34198617; rs12533953; rs12690; rs13238927; rs2631608; rs2693748; rs2727456; rs2727465; rs34629832; rs3734926; rs4728179; rs6980213; rs873664

# Metabolic_Enzyme_40_General_References:
8132613

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
5862

# Metabolic_Enzyme_41_Name:
High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

# Metabolic_Enzyme_41_Synonyms:
HCP1; TM22

# Metabolic_Enzyme_41_Gene_Name:
PDE7A

# Metabolic_Enzyme_41_Protein_Sequence:
>Highaffinity cAMPspecific 3',5'cyclic phosphodiesterase 7
AMEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQT
ALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLR
SSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS
LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP
WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLF
SHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALK
CADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTY
LVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQEN
RLS

# Metabolic_Enzyme_41_Number_of_Residues:
482

# Metabolic_Enzyme_41_Molecular_Weight:
55506

# Metabolic_Enzyme_41_Theoretical_pI:
7.53

# Metabolic_Enzyme_41_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_41_General_Function:
Not Available

# Metabolic_Enzyme_41_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase is highly specific for cAMP and may have a role in muscle signal transduction

# Metabolic_Enzyme_41_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_41_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_41_Signals:
None

# Metabolic_Enzyme_41_Transmembrane_Regions:
None

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_41_GenBank_ID_Protein:
5566609

# Metabolic_Enzyme_41_SwissProt_ID:
PDE7A_HUMAN (Q13946)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
PDE7A

# Metabolic_Enzyme_41_Geneatlas_id:
PDE7A

# Metabolic_Enzyme_41_hgnc_id:
HGNC:8791

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. PDE7A2 (50 kDa) is located to particulate cellular fractions

# Metabolic_Enzyme_41_Gene_Sequence:
>1449 bp
ATGGAAGTGTGTTACCAGCTGCCGGTACTGCCCCTGGACAGGCCGGTCCCCCAGCACGTC
CTCAGCCGCCGAGGAGCCATCAGCTTCAGCTCCAGCTCCGCTCTCTTCGGCTGCCCCAAT
CCCCGGCAGCTCTCTCAGAGGCGTGGAGCTATTTCCTATGACAGTTCTGATCAGACTGCA
TTATACATTCGTATGCTAGGAGATGTACGTGTAAGGAGCCGAGCAGGATTTGAATCAGAA
AGAAGAGGTTCTCACCCATATATTGATTTTCGTATTTTCCACTCTCAATCTGAAATTGAA
GTGTCTGTCTCTGCAAGGAATATCAGAAGGCTACTAAGTTTCCAGCGATATCTTAGATCT
TCACGCTTTTTTCGTGGTACTGCGGTTTCAAATTCCCTAAACATTTTAGATGATGATTAT
AATGGACAAGCCAAGTGTATGCTGGAAAAAGTTGGAAATTGGAATTTTGATATCTTTCTA
TTTGATAGACTAACAAATGGAAATAGTCTAGTAAGCTTAACCTTTCATTTATTTAGTCTT
CATGGATTAATTGAGTACTTCCATTTAGATATGATGAAACTTCGTAGATTTTTAGTTATG
ATTCAAGAAGATTACCACAGTCAAAATCCTTACCATAACGCAGTCCACGCTGCGGATGTT
ACTCAGGCCATGCACTGTTACTTAAAGGAACCTAAGCTTGCCAATTCTGTAACTCCTTGG
GATATCTTGCTGAGCTTAATTGCAGCTGCCACTCATGATCTGGATCATCCAGGTGTTAAT
CAACCTTTCCTTATTAAAACTAACCATTACTTGGCAACTTTATACAAGAATACCTCAGTA
CTGGAAAATCACCACTGGAGATCTGCAGTGGGCTTATTGAGAGAATCAGGCTTATTCTCA
CATCTGCCATTAGAAAGCAGGCAACAAATGGAGACACAGATAGGTGCTCTGATACTAGCC
ACAGACATCAGTCGCCAGAATGAGTATCTGTCTTTGTTTAGGTCCCATTTGGATAGAGGT
GATTTATGCCTAGAAGACACCAGACACAGACATTTGGTTTTACAGATGGCTTTGAAATGT
GCTGATATTTGTAACCCATGTCGGACGTGGGAATTAAGCAAGCAGTGGAGTGAAAAAGTA
ACGGAGGAATTCTTCCATCAAGGAGATATAGAAAAAAAATATCATTTGGGTGTGAGTCCA
CTTTGCGATCGTCACACTGAATCTATTGCCAACATCCAGATTGGTTTTATGACTTACCTA
GTGGAGCCTTTATTTACAGAATGGGCCAGGTTTTCCAATACAAGGCTATCCCAGACAATG
CTTGGACACGTGGGGCTGAATAAAGCCAGCTGGAAGGGACTGCAGAGAGAACAGTCGAGC
AGTGAGGACACTGATGCTGCATTTGAGTTGAACTCACAGTTATTACCTCAGGAAAATCGG
TTATCATAA

# Metabolic_Enzyme_41_GenBank_ID_Gene:
L12052

# Metabolic_Enzyme_41_Chromosome_Location:
Not Available

# Metabolic_Enzyme_41_Locus:
Not Available

# Metabolic_Enzyme_41_SNPs:
Not Available

# Metabolic_Enzyme_41_General_References:
8389765; 9195912

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
5756

# Metabolic_Enzyme_42_Name:
Biotin--protein ligase

# Metabolic_Enzyme_42_Synonyms:
Biotin apo-protein ligase[Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Holocarboxylase synthetase; HCS; Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase

# Metabolic_Enzyme_42_Gene_Name:
HLCS

# Metabolic_Enzyme_42_Protein_Sequence:
>Biotinprotein ligase
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR

# Metabolic_Enzyme_42_Number_of_Residues:
726

# Metabolic_Enzyme_42_Molecular_Weight:
80761

# Metabolic_Enzyme_42_Theoretical_pI:
5.34

# Metabolic_Enzyme_42_GO_Classification:
>>>
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  biotin-protein ligase activity
Function:  biotin-[acetyl-CoA-carboxylase] ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_42_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_42_Specific_Function:
Posttranslational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

# Metabolic_Enzyme_42_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_42_Reaction:
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF02237:BPL_C;
PF03099:BPL_LipA_LipB

# Metabolic_Enzyme_42_Signals:
None

# Metabolic_Enzyme_42_Transmembrane_Regions:
None

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 6.3.4.9;EC 6.3.4.10;EC

# Metabolic_Enzyme_42_GenBank_ID_Protein:
577625

# Metabolic_Enzyme_42_SwissProt_ID:
BPL1_HUMAN (P50747)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
HLCS

# Metabolic_Enzyme_42_Geneatlas_id:
HLCS

# Metabolic_Enzyme_42_hgnc_id:
HGNC:4976

# Metabolic_Enzyme_42_PDB_ID:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Cytoplasm. Mitochondrion

# Metabolic_Enzyme_42_Gene_Sequence:
>2181 bp
ATGGAAGATAGACTCCACATGGATAATGGACTGGTACCCCAAAAGATTGTGTCGGTGCAC
TTGCAGGACTCCACTCTGAAGGAAGTTAAGGATCAGGTCTCAAACAAGCAAGCCCAGATC
CTAGAGCCGAAGCCTGAACCTTCTCTTGAGATTAAGCCTGAGCAGGACGGTATGGAGCAT
GTTGGCAGAGATGACCCAAAGGCTCTTGGTGAAGAACCCAAACAAAGGAGAGGCAGTGCC
TCTGGGAGTGAGCCTGCTGGGGACAGTGACAGGGGAGGGGGCCCCGTTGAGCATTATCAC
CTCCATCTGTCTAGTTGCCACGAGTGTCTGGAACTTGAGAACAGCACCATTGAGTCAGTC
AAGTTTGCGTCTGCCGAGAACATTCCAGACCTTCCCTACGATTATAGCAGCAGTTTGGAG
AGTGTTGCTGATGAGACCTCCCCCGAAAGAGAAGGGAGGAGAGTCAACCTCACGGGAAAG
GCACCCAACATCCTCCTCTATGTGGGCTCCGACTCCCAGGAAGCCCTCGGCCGGTTCCAC
GAGGTCCGGTCTGTGCTGGCCGACTGTGTGGACATTGACAGTTATATTCTCTACCACCTG
CTGGAGGACAGTGCTCTCAGAGACCCGTGGACGGACAACTGTCTGCTGTTGGTCATTGCT
ACCAGGGAGTCCATTCCCGAAGACCTGTACCAGAAGTTCATGGCCTATCTTTCTCAGGGA
GGGAAGGTGTTGGGCCTGTCTTCATCCTTCACCTTTGGTGGCTTTCAGGTGACAAGCAAG
GGTGCACTGCACAAGACAGTCCAGAACTTGGTTTTCTCCAAGGCTGACCAGAGCGAGGTG
AAGCTCAGCGTCTTGAGCAGTGGCTGCAGGTACCAGGAAGGCCCCGTCCGGCTCAGCCCC
GGCAGGCTCCAGGGCCACCTGGAGAATGAGGACAAGGACAGGATGATTGTGCATGTGCCT
TTTGGAACTCGCGGGGGAGAAGCTGTTCTTTGCCAGGTGCACTTAGAACTACCTCCCAGC
TCCAACATAGTGCAAACTCCAGAAGATTTTAACTTGCTCAAGTCAAGCAATTTTAGAAGA
TACGAAGTCCTTAGAGAGATTCTGACAACCCTTGGCCTCAGCTGTGACATGAAACAAGTT
CCTGCCTTAACTCCTCTTTACTTGCTGTCAGCTGCGGAGGAAATCAGGGATCCTCTTATG
CAGTGGCTTGGGAAACATGTGGACTCCGAGGGAGAAATAAAATCCGGCCAGCTCTCTCTT
AGATTTGTTTCATCCTACGTGTCTGAAGTAGAAATAACCCCATCTTGTATACCTGTGGTG
ACCAACATGGAGGCCTTCTCATCAGAACATTTCAACTTAGAGATCTATCGCCAAAATCTG
CAGACCAAGCAGTTGGGGAAAGTAATTTTGTTTGCCGAAGTGACCCCCACAACGATGCGT
CTCCTGGATGGGCTGATGTTTCAGACACCGCAGGAAATGGGCTTAATAGTGATCGCGGCC
CGGCAGACCGAGGGCAAAGGACGGGGAGGGAATGTGTGGCTGAGCCCTGTGGGATGTGCT
CTTTCTACTCTGCTCATCTCCATTCCACTGAGATCCCAGCTGGGACAGAGGATCCCGTTT
GTCCAGCATCTGATGTCCGTGGCTGTCGTGGAAGCAGTGAGGTCCATTCCCGAGTATCAG
GATATCAACTTACGAGTGAAGTGGCCCAACGATATTTATTACAGTGACCTCATGAAGATC
GGCGGAGTTCTGGTTAACTCAACACTCATGGGAGAAACATTTTATATACTTATTGGCTGT
GGATTTAATGTGACTAACAGTAACCCTACCATCTGCATCAACGACCTCATCACAGAATAC
AATAAACAACACAAGGCAGAACTGAAGCCCTTAAGAGCCGATTATCTCATCGCCAGAGTC
GTGACTGTGCTGGAGAAACTGATCAAAGAGTTTCAGGACAAAGGGCCCAACAGCGTCCTT
CCCCTTTATTACCGATACTGGGTCCACAGTGGTCAGCAAGTCCATCTGGGCAGCGCAGAG
GGACCAAAGGTGTCCATCGTTGGCCTGGACGATTCTGGCTTCCTCCAGGTTCACCAGGAG
GGCGGCGAGGTTGTGACTGTGCACCCGGACGGCAACTCCTTCGACATGCTGAGAAACCTC
ATCCTCCCCAAACGGCGGTAA

# Metabolic_Enzyme_42_GenBank_ID_Gene:
D23672

# Metabolic_Enzyme_42_Chromosome_Location:
Not Available

# Metabolic_Enzyme_42_Locus:
Not Available

# Metabolic_Enzyme_42_SNPs:
rs1065759; rs1065758; rs2230182; rs2835547; rs2835543; rs2835554; rs2835544; rs1892916; rs2835553; rs2835545; rs2016215; rs2835557; rs2835546; rs2835552; rs9636908; rs2835548; rs2835555; rs1893653; rs2835550; rs2843637; rs3827189; rs2835549; rs2835541; rs4817839; rs12626528; rs8126588; rs8127595; rs2835551; rs11910240; rs12627541; rs6517397; rs369888; rs2835556; rs10084553; rs2845814; rs4816551; rs2409871; rs12483284; rs1571702; rs4817840; rs762373; rs445437; rs997627; rs2032087; rs12483456; rs762376; rs1893654; rs7277523; rs1893655; rs1571700; rs9978381; rs727961; rs6517396; rs3827190; rs3179477; rs6517395; rs4816557; rs7281321; rs14407; rs7276605; rs7283846; rs2409870; rs7277447; rs3819154; rs7282108; rs7280331; rs13052315; rs8127236; rs2835542; rs762374; rs12626531; rs1050706; rs7281251; rs2154530; rs13048613; rs13049125; rs11700650; rs9636909; rs8129634; rs11909178; rs11702480; rs9981774; rs9983516; rs1007423; rs11701986; rs8131277; rs7509886; rs7276406; rs4817832; rs2154533; rs762375; rs12482985; rs4817835; rs11909152; rs2154532; rs8126740; rs4816553; rs2843627; rs7276518; rs1012962; rs7280892; rs1986063; rs9981407; rs16997934; rs7509870; rs1055700; rs2016219; rs8130063; rs3191054; rs7276371; rs9967991; rs412162; rs2154529; rs7282422; rs1050707; rs4817838; rs12626619; rs1055699; rs2032086; rs1007421; rs10084551; rs4817834; rs12626945; rs2843633; rs9974970; rs9976131; rs2835520; rs2835489; rs2835535; rs2835505; rs2835472; rs2835531; rs2835463; rs2073425; rs2835516; rs765321; rs1984020; rs2835537; rs2835511; rs2835506; rs745147; rs2835532; rs2835480; rs2256034; rs2245447; rs2835515; rs2835483; rs2835455; rs2835454; rs2245524; rs2835474; rs2835510; rs2835487; rs1041437; rs2835538; rs2000550; rs2835539; rs2835534; rs2835486; rs2835465; rs2835485; rs2835519; rs2835513; rs2245349; rs2835525; rs2073424; rs3827185; rs3787749; rs2835508; rs2835467; rs7280984; rs2835491; rs2073420; rs2236435; rs2835499; rs762369; rs1892913; rs2156419; rs8134067; rs999373; rs1010385; rs3787755; rs2835500; rs2835458; rs8129544; rs3787759; rs7280602; rs2835527; rs6517385; rs2000549; rs2835484; rs2835471; rs8127309; rs999372; rs2835461; rs6517394; rs3787741; rs2835478; rs2835488; rs2835498; rs6517390; rs2835468; rs8130819; rs2835481; rs2835495; rs2835477; rs2245353; rs3787756; rs8134742; rs11088366; rs12627703; rs2835497; rs2835482; rs2835517; rs2835529; rs2835493; rs2835533; rs2835464; rs1015017; rs9978519; rs743429; rs2835503; rs2835509; rs8134293; rs2835514; rs2835473; rs8133376; rs8129637; rs762370; rs2835502; rs3787771; rs1467857; rs2835476; rs9981318; rs2835466; rs3787751; rs2835526; rs3787764; rs6517386; rs2835528; rs766212; rs928845; rs2835504; rs8131323; rs8133029; rs9977855; rs2835459; rs2187305; rs2835479; rs2156420; rs7282868; rs2835530; rs12627271; rs2835501; rs6517384; rs11702761; rs1009778; rs2845810; rs3787739; rs2845805; rs8131621; rs3787752; rs9941899; rs7278038; rs9981513; rs4402840; rs2835524; rs2845811; rs1023409; rs12627285; rs11910692; rs8134448; rs2850120; rs2835507; rs2835496; rs6517392; rs8130179; rs2073421; rs6517389; rs11701858; rs3787748; rs11088368; rs16994604; rs12627666; rs9981651; rs2835475; rs2073419; rs2835494; rs2016223; rs12151959; rs2845804; rs2835518; rs2845812; rs6517391; rs9977488; rs7279278; rs2835470; rs8132538; rs7275269; rs2276230; rs9680246; rs10483036; rs2835523; rs2835490; rs10154119; rs6517388; rs13047304; rs1029248; rs8131480; rs11088367; rs7276758; rs2070523; rs3827187; rs8134687; rs12481910; rs2835453; rs743430; rs2409842; rs2073422; rs16994521; rs7276082; rs2835457; rs7276265; rs12627662; rs762367; rs9977769; rs3787757; rs2835536; rs13050480; rs2835469; rs2409865; rs2850104; rs2850106; rs11910768; rs7275322; rs725719; rs2105752; rs11702134; rs2236434; rs8134083; rs2845817; rs1029247; rs2835492; rs2835521; rs13052249; rs6517387; rs2073423; rs4817822; rs9636905; rs9647169; rs8127553; rs13047322; rs3787754; rs732252; rs1041832; rs8130235; rs8132874; rs16994508; rs3827188; rs2835462; rs7276185; rs2898312; rs7278981; rs8133818; rs999374; rs11911767; rs16994519; rs11701035; rs3787750; rs2073418; rs2850118; rs3787765; rs7277563; rs2835460; rs17228878; rs11701632; rs13050751; rs8131510; rs8129230; rs8132327; rs7278075; rs6517381; rs2245325; rs3842450; rs4817828; rs7283004; rs16997932; rs12627476; rs7281419; rs16994573; rs11700783; rs2065303; rs17192962; rs11700880; rs8129291; rs8131843; rs11088365; rs4501027; rs8132225; rs3838087; rs7278053; rs12627335; rs933159; rs762368; rs3787767; rs7280590; rs12481800; rs8130004; rs3787753; rs12483475; rs17814272; rs10451759; rs8129887; rs2282501; rs9647072; rs7510213; rs8132547; rs12482724; rs3787768; rs4817823; rs1968034; rs16994591; rs12626955; rs9977713; rs8126803; rs7279810; rs12626368; rs16994424; rs2845819; rs11702434; rs8129140; rs8132325; rs960498; rs11702727; rs8130658; rs1968035; rs12627519; rs3787740; rs17814278; rs13052574; rs9978312; rs4817821; rs8134086; rs11909707; rs8131697; rs16994586; rs4146071; rs3787760; rs7509790; rs7280746; rs11909766; rs2835522; rs2850119; rs2845813; rs7279818; rs16994438; rs2409867; rs11911648; rs7283401; rs17228899; rs1892912; rs17284196; rs16994530; rs2835456; rs9305605; rs11701958; rs11910919; rs7283417; rs16994503; rs2835512; rs7283871; rs16994435; rs8130485; rs8130689; rs9985116; rs10154239; rs7280597; rs2850105; rs16994594; rs2850103; rs7280357; rs7283538; rs13045992; rs11088364; rs2898305; rs2032320; rs2096494; rs28934602; rs10586592; rs7280923; rs11393391; rs4817837; rs3035109; rs10555694; rs6147500; rs28593435; rs2010867; rs13050516; rs4816555; rs35275580; rs11911628; rs3035147; rs13047776; rs10439668; rs2250250; rs9976746; rs35410170; rs34322027; rs11088370; rs9978378; rs34080483; rs4817833; rs5843777; rs34917953; rs12481939; rs35414914; rs7283304; rs8130102; rs35626237; rs4817836; rs34507014; rs3035114; rs11911653; rs35627163; rs35955622; rs35662085; rs35497414; rs2154531; rs12627081; rs9975027; rs13046475; rs9980304; rs7281145; rs10714466; rs35614243; rs9979522; rs11327894; rs35458660; rs34562090; rs28690635; rs33973072; rs28429232; rs34401947; rs11446217; rs11386640; rs8131045; rs35291269; rs28650072; rs1571701; rs4816552; rs34710014; rs12627106; rs2848944; rs28694191; rs28530; rs11326506; rs3031056; rs34107101; rs10572120; rs35365431; rs10658878; rs28873986; rs35392286; rs35583976; rs2845823; rs35174119; rs34036236; rs35269254; rs11345329; rs7276359; rs7280124; rs2848945; rs7276076; rs13050356; rs5843783; rs13049535; rs35601107; rs34807872; rs2845822; rs1540010; rs2843959; rs34377311; rs12626655; rs35868871; rs35980239; rs35710980; rs4816554; rs35634082; rs13049080; rs34220466; rs35662012; rs35520036; rs34080155; rs13046468; rs13050438; rs3035105; rs7280358; rs13050355; rs35779811; rs36112603; rs28610288; rs13050617; rs8128381; rs12481773; rs3787776; rs35700333; rs3035112; rs33951816; rs13051338; rs9984942; rs13052725; rs34357006; rs8133111; rs36042341; rs9983255; rs35509622; rs2850116; rs35869521; rs11294369; rs35182597; rs4437044; rs11297044; rs12483583; rs9305606; rs9680205; rs35822038; rs5843781; rs11702621; rs13053024; rs35796252; rs35095559; rs34254252; rs2845809; rs34407031; rs34091454; rs12152092; rs11701245; rs34788426; rs11390960; rs1892914; rs2409866; rs10533053; rs13050215; rs34132309; rs1080320; rs11367391; rs34296856; rs4817819; rs34750859; rs7510407; rs10222039; rs10222041; rs34494258; rs36115487; rs10527838; rs7281668; rs10675191; rs12482385; rs36094571; rs34518438; rs11700970; rs7280703; rs35996984; rs34580139; rs11701954; rs4816549; rs36030626; rs35066001; rs7278768; rs35736294; rs28433522; rs34042688; rs10667373; rs34834985; rs35033735; rs28420273; rs34614171; rs4817826; rs13048483; rs10578979; rs34474993; rs9978513; rs35086153; rs7281557; rs35055957; rs28717023; rs34606135; rs34108918; rs34352427; rs9305607; rs4817820; rs10673271; rs34525201; rs11464249; rs10671954; rs34011883; rs34569598; rs13048364; rs35780817; rs3787762; rs1807005; rs7277291; rs35188541; rs2850117; rs35393537; rs34364909; rs11297456; rs34450454; rs6517380; rs34753772; rs2845818; rs34057978; rs8128030; rs34115036; rs7276860; rs35778622; rs2845808; rs11384058; rs12626778; rs10701851; rs35753864; rs13049458; rs9980828; rs8127419; rs35751606; rs11909879; rs11297170; rs35402890; rs34791770; rs35945376; rs34814328; rs28478303; rs2850107; rs34260234; rs10660857; rs12482621; rs34247489; rs34777766; rs11306825; rs36038593; rs34292112; rs34938617; rs11418922; rs34340177; rs8133296; rs11317768; rs7278191; rs2898307; rs9975316; rs11701120; rs34199456; rs36086662; rs11291576; rs35352430; rs35493457; rs8130859; rs34541224; rs2845815; rs9979967; rs35818278; rs8134476; rs35808041; rs33933191; rs34276663; rs17461392; rs13047682; rs7283722; rs28837399; rs2845807; rs2845816; rs13047748; rs12627632; rs34836716; rs7281692; rs34141324; rs8134223; rs35389223; rs8127533; rs35468614; rs8128099; rs35329905; rs11908840; rs12627303; rs10460714; rs7278010; rs34602439; rs34203769; rs2409864; rs1023151; rs28393024; rs34954888; rs34016490; rs35012674; rs8134332; rs35663376; rs35419478; rs13047923; rs35436718; rs4146072; rs34087473; rs36053269; rs34963503; rs9305608; rs9636906; rs34820991; rs35737292; rs35524379; rs7277631; rs3787747; rs34722227; rs11464248; rs34473124; rs34498809; rs5843779; rs4817824; rs11344082; rs10683958; rs766213; rs36004832; rs35877361; rs36071670; rs10601692; rs8127710; rs35854823; rs34695780; rs2898306; rs34861975; rs11445706; rs3787763; rs35372493; rs35181716; rs4817829; rs35148498; rs13052306; rs34623773; rs9982979; rs34491680; rs8128357; rs765322; rs12627215; rs35114323; rs34254349; rs7279029; rs5843780; rs4817825; rs6517382; rs8134282; rs3838088; rs35086549; rs35178355; rs36094620; rs2845806; rs34601566; rs16994535; rs34372660; rs2409841; rs7276595; rs34045793; rs35693831; rs9636907; rs33997626; rs35529573; rs13049750; rs9631176; rs35395049; rs35754533; rs34877069; rs35184977; rs28625302; rs11701876; rs34016299; rs3840081; rs2409868; rs11287408; rs35744528; rs11908847; rs35420087; rs11290275; rs11323079; rs35056286; rs10699749; rs35246209; rs11464250; rs7280002; rs5843778; rs35247519; rs11353178; rs36000333; rs11088363; rs34153712; rs34389255; rs16994517; rs35042573; rs36027016; rs35323345; rs11701088; rs11464247; rs34592171; rs35050680; rs34390839; rs10696901; rs8127560; rs34392668; rs9680178; rs34427088; rs9984754; rs36040380; rs34908465; rs7282396; rs34792541; rs3132398; rs2843630; rs3094305; rs2843629; rs35788112; rs1005404; rs12627480; rs13050453; rs13052602; rs16994660; rs1892915; rs1893656; rs1970053; rs2002799; rs2051397; rs2070519; rs2070520; rs2073416; rs2073417; rs2073601; rs2073602; rs2073603; rs2186335; rs2187102; rs2409872; rs2835451; rs2835540; rs2843961; rs7281817; rs8131293; rs8132470; rs877686; rs9982519

# Metabolic_Enzyme_42_General_References:
7842009; 11735028; 10830953; 9503011; 8541348; 8817339; 9396568; 10190325

# Metabolic_Enzyme_42_References:
Not Available

# Metabolic_Enzyme_43_ID:
5863

# Metabolic_Enzyme_43_Name:
Arginyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_43_Synonyms:
Arginine--tRNA ligase; ArgRS

# Metabolic_Enzyme_43_Gene_Name:
RARS

# Metabolic_Enzyme_43_Protein_Sequence:
>ArginyltRNA synthetase, cytoplasmic
MDVLVSECSARLLQQEEEIKSLTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRK
SLQAERNKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTPSQQAKFGDYQCNSAMG
ISQMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLV
NGVQLPALGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGD
WGTQFGMLIAHLQDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGK
NPDITKAWKLICDVSRQELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDG
RKIVFVPGCSIPLTIVKSDGGYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIF
AAAQMIGWYDPKVTRVFHAGFGVVLGEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEK
ERDKVLTAEELNAAQTSVAYGCIKYADLSHNRLNDYIFSFDKMLDDRGNTAAYLLYAFTR
IRSIARLANIDEEMLQKAARETKILLDHEKEWKLGRCILRFPEILQKILDDLFLHTLCDY
IYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM


# Metabolic_Enzyme_43_Number_of_Residues:
660

# Metabolic_Enzyme_43_Molecular_Weight:
75380

# Metabolic_Enzyme_43_Theoretical_pI:
6.65

# Metabolic_Enzyme_43_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  arginine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  arginyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_43_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_43_Specific_Function:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

# Metabolic_Enzyme_43_Pathway:
map00330  Arginine and proline metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_43_Reaction:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

# Metabolic_Enzyme_43_Pfam_Domain_Function:
PF03485:Arg_tRNA_synt_N;
PF05746:DALR_1;
PF00750:tRNA-synt_1d

# Metabolic_Enzyme_43_Signals:
None

# Metabolic_Enzyme_43_Transmembrane_Regions:
None

# Metabolic_Enzyme_43_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_43_EC_Link:
EC 6.1.1.19

# Metabolic_Enzyme_43_GenBank_ID_Protein:
1217668

# Metabolic_Enzyme_43_SwissProt_ID:
SYRC_HUMAN (P54136)

# Metabolic_Enzyme_43_swissprot_Name:
Not Available

# Metabolic_Enzyme_43_Genecard_id:
RARS

# Metabolic_Enzyme_43_Geneatlas_id:
RARS

# Metabolic_Enzyme_43_hgnc_id:
HGNC:9870

# Metabolic_Enzyme_43_PDB_ID:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_43_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_43_Gene_Sequence:
>1980 bp
ATGGACGTACTGGTGTCTGAGTGCTCCGCGCGGCTGCTGCAGCAGGAAGAAGAGATTAAA
TCTCTGACTGCTGAAATTGACCGGTTGAAAAACTGTGGCTGTTTAGGAGCTTCTTCAAAT
TTGGAGCAGTTACAAGAAGAAAATTTAAAATTAAAGTATCGACTGAATATTCTTCGAAAG
AGTCTTCAGGCAGAAAGGAACAAACCAACTAAAAATATGATTAACATTATTAGCCGCCTA
CAAGAGGTCTTTGGTCATGCAATTAAGGCTGCATATCCAGATTTGGAAAATCCTCCTCTG
CTAGTGACACCAAGTCAGCAGGCCAAGTTTGGGGACTATCAGTGTAATAGTGCTATGGGT
ATTTCTCAGATGCTTAAAACCAAGGAACCGGAAGTTAATCCAGGGGAATTTGCTGAAAAC
ATTACCAAACACCTCCCGGCCATGGATGTTTTGAAAAGAGTTGAATTTGCTGGCCCTGGC
TTTATTAATGGCCACTTAAGAAAGGATTTTGTATCAGAACAATTGACCAGTCTTCTAGTG
AATGGAGTTCAACTACCTGCTCTGGGAGAGAATAAAAAGGTTATAGTTGACTTTTCCTCC
CCTAATATAGCTAAAGAGATGCATGTAGGCCACCTGAGGTCAACTATCATAGGAGAGAGT
ATAAGCCGCCTCTTTGAATTTGCAGGGTATGACGTGCTCAGGTTAAATCATGTAGGAGAC
TGGGGGACCCAGTTTGGCATGCTCATCGCTCACCTGCAAGACAAATTTCCAGATTATCTA
ACAGTTTCACCTCCTATTGGGGATCTTCAGGTCTTTTATAAGGAATCTAAGAAGAGGTTT
GATACTGAGGAGGAATTTAAGAAGCGAGCATATCAGTGTGTAGTTCTGCTCCAGGGTAAA
AACCCAGATATTACAAAAGCTTATCTGCTGATGTCTGATGTCTCCCGCCAAGAGTTAAAT
AAAATCTATGATGCATTGGACGTCTCTTTAATAGAGAGAGGGGAATCCTTCTATCAAGAT
AGGATGAATGATATTGTAAAGGAATTTGAAGATAGAGGATTTGTGCAGGTGGATGATGGC
AGAAAGATTGTATTTGTCCCAGGGTGTTCCATACCATTAACCATAGTAAAATCAGATGGA
GGTTATACCTATGATACATCTGACCTGGCTGCTATTAAACAAAGACTATTTGAGGAAAAA
GCAGATATGATTATCTATGTTGTGGACAATGGACAATCTGTGCACTTCCAGACAATATTT
GCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTAACTCGAGTCTTCCATGCTGGA
TTTGGTGTGGTGCTAGGGGAAGACAAGAAAAAGTTTAAAACACGTTCGGGTGAAACAGTG
CGCCTCATGGATCTTCTGGGAGAAGGACTAAAACGATCCATGGACAAGTTGAAGGAAAAA
GAAAGAGACAAGGTCTTAACTGCAGAGGAATTGAATGCTGCTCAGACATCCGTTGCATAT
GGCTGCATCAAATATGCTGACCTTTCCCATAACCGGTTGAATGACTACATCTTCTCCTTT
GACAAAATGCTAGATGACAGAGGAAATACAGCTGCTTACTTGTTGTATGCCTTCACTAGA
ATCAGGTCTATTGCACGTCTGGCCAATATTGATGAAGAAATGCTCCAAAAAGCTGCTCGA
GAAACCAAGATTCTTTTGGTTCATGAGAAGGAATGGAAACTAGGCCGGTGCATTTTACGG
TTCCCTGAGATTCTGCAAAAGATTTTAGATGACTTATTTCTCCACACTCTCTGTGATTAT
ATATATGAGCTGGCAACTGCTTTCACAGAGTTCTATGATAGCTGCTACTGTGTGGAGAAA
GATAGACAGACTGGGAAAATATTGAAGGTGAACATGTGGCGTATCTTGTGTGAAACAGTA
GCTGCTGTCATGGCCAAGGGGTTTGATACCCTGGGGATAAAACCTGGCCCAAGGGTGTAA


# Metabolic_Enzyme_43_GenBank_ID_Gene:
S80343

# Metabolic_Enzyme_43_Chromosome_Location:
Not Available

# Metabolic_Enzyme_43_Locus:
Not Available

# Metabolic_Enzyme_43_SNPs:
Not Available

# Metabolic_Enzyme_43_General_References:
7590355; 12665801

# Metabolic_Enzyme_43_References:
Not Available

# Metabolic_Enzyme_44_ID:
5864

# Metabolic_Enzyme_44_Name:
GMP synthase [glutamine-hydrolyzing]

# Metabolic_Enzyme_44_Synonyms:
Glutamine amidotransferase; GMP synthetase

# Metabolic_Enzyme_44_Gene_Name:
GMPS

# Metabolic_Enzyme_44_Protein_Sequence:
>GMP synthase glutaminehydrolyzing
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE

# Metabolic_Enzyme_44_Number_of_Residues:
693

# Metabolic_Enzyme_44_Molecular_Weight:
76716

# Metabolic_Enzyme_44_Theoretical_pI:
6.86

# Metabolic_Enzyme_44_GO_Classification:
>>>
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  GMP synthase (glutamine-hydrolyzing) activity
Function:  molecular function unknown
Function:  catalytic activity
 ||
>>>
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
Process:  GMP biosynthesis
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_44_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_44_Specific_Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division

# Metabolic_Enzyme_44_Pathway:
map00230  Purine metabolism;
 map00251  Glutamate metabolism

# Metabolic_Enzyme_44_Reaction:
ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate

# Metabolic_Enzyme_44_Pfam_Domain_Function:
PF06508:ExsB;
PF00117:GATase;
PF00958:GMP_synt_C

# Metabolic_Enzyme_44_Signals:
None

# Metabolic_Enzyme_44_Transmembrane_Regions:
None

# Metabolic_Enzyme_44_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_44_EC_Link:
EC 6.3.5.2

# Metabolic_Enzyme_44_GenBank_ID_Protein:
595410

# Metabolic_Enzyme_44_SwissProt_ID:
GUAA_HUMAN (P49915)

# Metabolic_Enzyme_44_swissprot_Name:
Not Available

# Metabolic_Enzyme_44_Genecard_id:
GMPS

# Metabolic_Enzyme_44_Geneatlas_id:
GMPS

# Metabolic_Enzyme_44_hgnc_id:
HGNC:4378

# Metabolic_Enzyme_44_PDB_ID:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_44_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_44_Gene_Sequence:
>2082 bp
ATGGCTCTGTGCAACGGAGACTCCAAGCTGGAGAATGCTGGAGGAGACCTTAAGGATGGC
CACCACCACTATGAAGGAGCTGTTGTCATTCTGGATGCTGGTGCTCAGTACGGGAAAGTC
ATAGACCGAAGAGTGAGGGAACTGTTCGTGCAGTCTGAAATTTTCCCCTTGGAAACACCA
GCATTTGCTATAAAGGAACAAGGATTCCGTGCTATTATCATCTCTGGAGGACCTAATTCT
GTGTATGCTGAAGATGCTCCCTGGTTTGATCCAGCAATATTCACTATTGGCAAGCCTGTT
CTTGGAATTTGCTATGGTATGCAGATGATGAATAAGGTATTTGGAGGTACTGTGCACAAA
AAAAGTGTCAGAGAAGATGGAGTTTTCAACATTAGTGTGGATAATACATGTTCATTATTC
AGGGGCCTTCAGAAGGAAGAAGTTGTTTTGCTTACACATGGAGATAGTGTAGACAAAGTA
GCTGATGGATTCAAGGTTGTGGCACGTTCTGGAAACATAGTAGCAGGCATAGCAAATGAA
TCTAAAAAGTTATATGGAGCACAGTTCCACCCTGAAGTTGGCCTTACAGAAAATGGAAAA
GTAATACTGAAGAATTTCCTTTATGATATAGCTGGATGCAGTGGAACCTTCACCGTGCAG
AACAGAGAACTTGAGTGTATTCGAGAGATCAAAGAGAGAGTAGGCACGTCAAAAGTTTTG
GTTTTACTCAGTGGTGGAGTAGACTCAACAGTTTGTACAGCTTTGCTAAATCGTGCTTTG
AACCAAGAACAAGTCATTGCTGTGCACATTGATAATGGCTTTATGAGAAAACGAGAAAGC
CAGTCTGTTGAAGAGGCCCTCAAAAAGCTTGGAATTCAGGTCAAAGTGATAAATGCTGCT
CATTCTTTCTACAATGGAACAACAACCCTACCAATATCAGATGAAGATAGAACCCCACGG
AAAAGAATTAGCAAAACGTTAAATATGACCACAAGTCCTGAAGAGAAAAGAAAAATCATT
GGGGATACTTTTGTTAAGATTGCCAATGAAGTAATTGGAGAAATGAACTTGAAACCAGAG
GAGGTTTTCCTTGCCCAAGGTACTTTACGGCCTGATCTAATTGAAAGTGCATCCCTTGTT
GCAAGTGGCAAAGCTGAACTCATCAAAACCCATCACAATGACACAGAGCTCATCAGAAAG
TTGAGAGAGGAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGA
ATTTTGGGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGT
CCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAACCTTATATTTGTAAGGACTTTCCT
GAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACAT
ACCCTATTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAA
ATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTGCCAATTAAAACTGTAGGTGTGCAG
GGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGG
GAATCACTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTT
GTTTATATATTTGGCCCACCAGTTAAAGAACCTCCTACAGATGTTACTCCCACTTTCTTG
ACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGG
GAGTCTGGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTT
GATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAGAGATCTGTGGTTATTCGAACCTTT
ATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAG
GTGGTATTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTAT
GACTTAACATCAAAGCCCCCAGGAACTACTGAGTGGGAGTAA

# Metabolic_Enzyme_44_GenBank_ID_Gene:
U10860

# Metabolic_Enzyme_44_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_44_Locus:
3q24

# Metabolic_Enzyme_44_SNPs:
rs7637292; rs10936021; rs12496896; rs12634592; rs4680220; rs401514; rs7617878; rs4108611; rs3772117; rs7615287; rs7636930; rs6441023; rs4679757; rs2067877; rs6766927; rs12491178; rs1356252; rs7633168; rs6799267; rs12493764; rs3821365; rs6441028; rs9825321; rs2320318; rs12489430; rs7619976; rs6441027; rs12491537; rs6775044; rs7643525; rs12494730; rs6441024; rs6806109; rs6441026; rs12634282; rs12492258; rs3772116; rs6441022; rs6797289; rs7651038; rs12636569; rs2068601; rs9882341; rs3772112; rs10804774; rs12490114; rs11716272; rs12638836; rs4679756; rs406701; rs7430851; rs12497968; rs9883153; rs3772115; rs9819269; rs11712694; rs12495418; rs2874232; rs410042; rs9820541; rs6800992; rs7652005; rs6441025; rs11714133; rs9820534; rs6791517; rs3732399; rs12485735; rs10804773; rs12493422; rs12494104; rs12496313; rs1878213; rs9840456; rs13060931; rs7650106; rs1878211; rs12496006; rs3772113; rs10936020; rs9868194; rs12491896; rs11706359; rs6777776; rs35910218; rs11547948; rs35848656; rs11915364; rs34537819; rs28438758; rs12107883; rs13324534; rs35759331; rs12386360; rs386067; rs445758; rs35973380; rs4680221; rs12386362; rs35962523; rs35285447; rs11334499; rs35811525; rs13327285; rs10640770; rs6768724; rs7633729; rs12386359; rs4399846; rs3772114; rs35321137; rs34337666; rs7620397; rs35275341; rs12633671; rs33927918; rs11437800; rs35876194; rs35954197; rs9855091; rs35651046; rs35140614; rs4057812; rs34658682; rs35475067; rs9631467; rs35494199; rs9846097; rs13061643; rs9862051; rs35510283; rs34118890; rs35377438; rs11716666; rs36101569; rs35285525; rs12497735; rs34117696; rs34290186; rs34712245; rs34327298; rs35833112; rs35357023; rs41267913; rs35724165; rs12638792; rs35031753; rs34182099; rs11430855; rs1878212; rs12486102; rs10691429; rs9864005; rs35664957; rs11425774; rs34609350; rs10548751; rs7625201; rs36079607; rs7645121; rs7620712; rs12493409; rs10704428; rs35628034; rs9832621; rs7428956; rs4680219; rs34125997; rs28655132; rs35440885; rs34101828; rs4383470; rs12633670; rs11391424; rs5853733; rs11410318; rs35247619; rs35984925; rs12486189; rs35552128; rs35402685; rs10613824; rs11411886; rs35667159; rs5853732; rs35386649; rs33978589; rs12485698; rs12485701; rs12485742; rs12485802; rs12486864; rs12488351; rs12493934; rs12493963; rs12494143; rs12497838; rs1533443; rs16825554; rs2063903; rs2292716; rs4679758; rs4680222; rs819846

# Metabolic_Enzyme_44_General_References:
8089153

# Metabolic_Enzyme_44_References:
Not Available

# Metabolic_Enzyme_45_ID:
5865

# Metabolic_Enzyme_45_Name:
Ubiquitin-conjugating enzyme E2 E3

# Metabolic_Enzyme_45_Synonyms:
Ubiquitin-protein ligase E3; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; UbcH9; UbcM2

# Metabolic_Enzyme_45_Gene_Name:
UBE2E3

# Metabolic_Enzyme_45_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E3
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLS
TSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDY
PFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV
GSIATQYLTNRAEHDRIARQWTKRYAT

# Metabolic_Enzyme_45_Number_of_Residues:
207

# Metabolic_Enzyme_45_Molecular_Weight:
22913

# Metabolic_Enzyme_45_Theoretical_pI:
7.25

# Metabolic_Enzyme_45_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_45_General_Function:
Not Available

# Metabolic_Enzyme_45_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest

# Metabolic_Enzyme_45_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_45_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_45_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_45_Signals:
None

# Metabolic_Enzyme_45_Transmembrane_Regions:
None

# Metabolic_Enzyme_45_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_45_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_45_GenBank_ID_Protein:
4586930

# Metabolic_Enzyme_45_SwissProt_ID:
UB2E3_HUMAN (Q969T4)

# Metabolic_Enzyme_45_swissprot_Name:
Not Available

# Metabolic_Enzyme_45_Genecard_id:
UBE2E3

# Metabolic_Enzyme_45_Geneatlas_id:
UBE2E3

# Metabolic_Enzyme_45_hgnc_id:
HGNC:12479

# Metabolic_Enzyme_45_PDB_ID:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_45_Subcellular_Location:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner

# Metabolic_Enzyme_45_Gene_Sequence:
>624 bp
ATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCA
GATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCT
TCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCC
ACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAAT
TGCAGTGCTGGGCCTAAAGGAGATAACATTTATGAATGGAGATCAACTATACTTGGTCCA
CCGGGTTCTGTATATGAAGGTGGTGTGTTTTTTCTGGATATCACATTTTCATCAGATTAT
CCATTTAAGCCACCAAAGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGT
CAGGGAGTCATCTGTCTGGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCA
AAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGCGGATCCTCTGGTT
GGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAG
TGGACCAAGAGATACGCAACATAA

# Metabolic_Enzyme_45_GenBank_ID_Gene:
AB017644

# Metabolic_Enzyme_45_Chromosome_Location:
Not Available

# Metabolic_Enzyme_45_Locus:
Not Available

# Metabolic_Enzyme_45_SNPs:
Not Available

# Metabolic_Enzyme_45_General_References:
10343118

# Metabolic_Enzyme_45_References:
Not Available

# Metabolic_Enzyme_46_ID:
5867

# Metabolic_Enzyme_46_Name:
Ubiquitin-conjugating enzyme E2 B

# Metabolic_Enzyme_46_Synonyms:
Ubiquitin-protein ligase B; Ubiquitin carrier protein B; HR6B; hHR6B; E2-17 kDa

# Metabolic_Enzyme_46_Gene_Name:
UBE2B

# Metabolic_Enzyme_46_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
BMSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEF
SEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPN
SPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

# Metabolic_Enzyme_46_Number_of_Residues:
152

# Metabolic_Enzyme_46_Molecular_Weight:
17312

# Metabolic_Enzyme_46_Theoretical_pI:
4.64

# Metabolic_Enzyme_46_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_46_General_Function:
Not Available

# Metabolic_Enzyme_46_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. May be involved in neurite outgrowth

# Metabolic_Enzyme_46_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_46_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_46_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_46_Signals:
None

# Metabolic_Enzyme_46_Transmembrane_Regions:
None

# Metabolic_Enzyme_46_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_46_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_46_GenBank_ID_Protein:
184046

# Metabolic_Enzyme_46_SwissProt_ID:
UBE2B_HUMAN (P63146)

# Metabolic_Enzyme_46_swissprot_Name:
Not Available

# Metabolic_Enzyme_46_Genecard_id:
UBE2B

# Metabolic_Enzyme_46_Geneatlas_id:
UBE2B

# Metabolic_Enzyme_46_hgnc_id:
HGNC:12473

# Metabolic_Enzyme_46_PDB_ID:
1JAS

# Metabolic_Enzyme_46_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_46_Subcellular_Location:
Cell membrane. Nucleus (By similarity). Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei (By similarity)

# Metabolic_Enzyme_46_Gene_Sequence:
>459 bp
ATGTCGACCCCGGCCCGGAGGAGGCTCATGCGGGATTTCAAGCGGTTACAAGAGGACCCA
CCTGTGGGTGTCAGTGGCGCACCATCTGAAAACAACATCATGCAGTGGAATGCAGTTATA
TTTGGACCAGAAGGGACACCTTTTGAAGATGGTACTTTTAAACTAGTAATAGAATTTTCT
GAAGAATATCCAAATAAACCACCAACTGTTAGGTTTTTATCCAAAATGTTTCATCCAAAT
GTGTATGCTGATGGTAGCATATGTTTAGATATCCTTCAGAATCGATGGAGTCCAACATAT
GATGTATCTTCTATCTTAACATCAATTCAGTCTCTGCTGGATGAACCGAATCCTAACAGT
CCAGCCAATAGCCAGGCAGCACAGCTTTATCAGGAAAACAAACGAGAATATGAGAAAAGA
GTTTCGGCCATTGTTGAACAAAGCTGGAATGATTCATAA

# Metabolic_Enzyme_46_GenBank_ID_Gene:
M74525

# Metabolic_Enzyme_46_Chromosome_Location:
Not Available

# Metabolic_Enzyme_46_Locus:
Not Available

# Metabolic_Enzyme_46_SNPs:
Not Available

# Metabolic_Enzyme_46_General_References:
2158443; 1717990; 10908344

# Metabolic_Enzyme_46_References:
Not Available

# Metabolic_Enzyme_47_ID:
5605

# Metabolic_Enzyme_47_Name:
ADP-dependent glucokinase

# Metabolic_Enzyme_47_Synonyms:
ADPGK; ADP-GK; RbBP-35

# Metabolic_Enzyme_47_Gene_Name:
ADPGK

# Metabolic_Enzyme_47_Protein_Sequence:
>ADPdependent glucokinase
MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAA
WDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFI
HFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNAALIGQKFAANSDLKVLLCGP
VGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPHANRFIFSHDLSNGAM
NMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS
MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILF
WILKEHGRSKSRASDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETI
DTSRVSLRAPQEFMTSHSEAGSRIVLNPNKPVVEWHREGISFHFTPVLVCKDPIRTVGLG
DAISAEGLFYSEVHPHY

# Metabolic_Enzyme_47_Number_of_Residues:
497

# Metabolic_Enzyme_47_Molecular_Weight:
54089

# Metabolic_Enzyme_47_Theoretical_pI:
6.17

# Metabolic_Enzyme_47_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
 ||
>>>
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_47_General_Function:
Not Available

# Metabolic_Enzyme_47_Specific_Function:
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency

# Metabolic_Enzyme_47_Pathway:
Not Available

# Metabolic_Enzyme_47_Reaction:
ADP + D-glucose = AMP + D-glucose 6-phosphate

# Metabolic_Enzyme_47_Pfam_Domain_Function:
PF04587:ADP_PFK_GK

# Metabolic_Enzyme_47_Signals:
1-22

# Metabolic_Enzyme_47_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_47_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_47_EC_Link:
EC 2.7.1.147

# Metabolic_Enzyme_47_GenBank_ID_Protein:
16923351

# Metabolic_Enzyme_47_SwissProt_ID:
ADPGK_HUMAN (Q9BRR6)

# Metabolic_Enzyme_47_swissprot_Name:
Not Available

# Metabolic_Enzyme_47_Genecard_id:
ADPGK

# Metabolic_Enzyme_47_Geneatlas_id:
ADPGK

# Metabolic_Enzyme_47_hgnc_id:
HGNC:25250

# Metabolic_Enzyme_47_PDB_ID:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_47_Subcellular_Location:
Not Available

# Metabolic_Enzyme_47_Gene_Sequence:
>1044 bp
ATGGGGAAGGGAGCAGCTGCTGAGCGCTTCTTCAGTGATAAGGAAACTTTTCACGACATT
GCCCAGGTTGCGTCAGAGTTCCCAGGAGCCCAGCACTATGTAGGAGGAAATGCAGCTTTA
ATTGGACAGAAATTTGCAGCCAACTCAGATTTAAAGGTTCTTCTTTGCGGTCCAGTTGGT
CCAAAGCTACATGAGCTTCTTGATGACAATGTCTTTGTTCCACCAGAGTCATTGCAGGAA
GTGGATGAGTTCCACCTCATTTTAGAGTATCAAGCAGGGGAGGAGTGGGGCCAGTTAAAA
GCTCCCCATGCCAACCGATTCATCTTCTCTCACGACCTCTCCAACGGGGCCATGAATATG
CTGGAGGTGTTTGTGTCTAGCCTGGAGGAGTTTCAGCCAGACCTGGTGGTCCTCTCTGGA
TTGCACATGATGGAGGGACAAAGCAAGGAGCTCCAGAGGAAGAGACTCTTGGAGGTTGTA
ACCTCCATTTCTGACATCCCCACTGGTATTCCAGTTCACCTAGAGCTGGCCAGTATGACT
AACAGGGAGCTCATGAGCAGCATTGTCCATCAGCAGGTCTTTCCCGCGGTGACTTCCCTT
GGGCTGAATGAACAGGAGCTGTTATTTCTCACCCAGTCAGCCTCTGGACCTCACTCTTCT
CTCTCTTCCTGGAACGGTGTTCCTGATGTGGGCATGGTCAGTGACATCCTCTTCTGGATC
TTGAAAGAACATGGGAGGAGTAAAAGCAGAGCCTCGGATCTCACCAGGATCCATTTCCAC
ACGCTGGTCTACCACATCCTGGCAACTGTGGATGGACACTGGGCCAACCAGCTGGCAGCC
GTGTTAGGAAGCTCGTGTGGCTGGGACACAGGCCTGCGCCACAGAAACCATAGACACCAG
CCGAGTGTCTCTGAGGGCACCCCAAGAGTTCATGACTTCCCATTCGGAGGCAGGCTCCAG
GATTGTATTAAACCCAAACAAGCCAGTAGTAGAATGGCACAGAGAGGGAATATCCTTCCA
CTTCACACCAGTATTGGTGTGTAA

# Metabolic_Enzyme_47_GenBank_ID_Gene:
AF204270

# Metabolic_Enzyme_47_Chromosome_Location:
Not Available

# Metabolic_Enzyme_47_Locus:
Not Available

# Metabolic_Enzyme_47_SNPs:
Not Available

# Metabolic_Enzyme_47_General_References:
11230166

# Metabolic_Enzyme_47_References:
Not Available

# Metabolic_Enzyme_48_ID:
5868

# Metabolic_Enzyme_48_Name:
Probable leucyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_48_Synonyms:
Leucine--tRNA ligase; LeuRS

# Metabolic_Enzyme_48_Gene_Name:
LARS2

# Metabolic_Enzyme_48_Protein_Sequence:
>Probable leucyltRNA synthetase, mitochondrial precursor
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
VQD

# Metabolic_Enzyme_48_Number_of_Residues:
903

# Metabolic_Enzyme_48_Molecular_Weight:
101977

# Metabolic_Enzyme_48_Theoretical_pI:
8.32

# Metabolic_Enzyme_48_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  leucine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  leucyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_48_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_48_Specific_Function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_48_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_48_Reaction:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_48_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00133:tRNA-synt_1;
PF09334:tRNA-synt_1g

# Metabolic_Enzyme_48_Signals:
None

# Metabolic_Enzyme_48_Transmembrane_Regions:
None

# Metabolic_Enzyme_48_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_48_EC_Link:
EC 6.1.1.4

# Metabolic_Enzyme_48_GenBank_ID_Protein:
40788954

# Metabolic_Enzyme_48_SwissProt_ID:
SYLM_HUMAN (Q15031)

# Metabolic_Enzyme_48_swissprot_Name:
Not Available

# Metabolic_Enzyme_48_Genecard_id:
LARS2

# Metabolic_Enzyme_48_Geneatlas_id:
LARS2

# Metabolic_Enzyme_48_hgnc_id:
HGNC:17095

# Metabolic_Enzyme_48_PDB_ID:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_48_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_48_Gene_Sequence:
>2715 bp
AGAATGGCTTCTGTTTGGCAGAGATTGGGTTTTTATGCCTCTCTTCTGAAAAGACAGCTA
AATGGTGGGCCAGATGTCATCAAGTGGGAAAGGAGAGTAATTCCCGGATGTACCAGAAGC
ATCTACAGTGCCACGGGAAAGTGGACAAAAGAGTATACATTGCAGACAAGAAAGGATGTT
GAGAAATGGTGGCATCAACGAATAAAAGAACAGGCCTCCAAAATTTCAGAAGCTGATAAA
TCGAAGCCAAAATTTTACGTGCTTTCCATGTTCCCTTATCCTTCTGGTAAGCTGCACATG
GGCCATGTGCGTGTCTACACCATCAGCGACACCATAGCACGGTTCCAGAAGATGAGAGGG
ATGCAGGTCATCAACCCCATGGGATGGGATGCTTTTGGATTGCCTGCTGAAAATGCCGCA
GTCGAGAGGAATCTACATCCACAAAGTTGGACACAAAGTAATATTAAACACATGAGGAAA
CAGCTTGATCGTCTGGGCCTGTGTTTCAGCTGGGATAGGGAAATAACTACGTGTTTGCCA
GATTACTACAAGTGGACTCAGTATCTCTTTATTAAACTGTATGAGGCTGGGCTGGCCTAT
CAAAAGGAGGCCCTGGTTAACTGGGACCCAGTGGATCAAACAGTGCTTGCCAATGAGCAG
GTGGATGAACATGGCTGTTCATGGCGTTCTGGAGCAAAGGTGGAACAGAAGTACCTCAGA
CAATGGTTTATTAAGACAACCGCTTATGCAAAGGCCATGCAGGACGCGTTGGCAGACCTT
CCAGAATGGTATGGAATAAAAGGCATGCAAGCCCACTGGATTGGGGACTGTGTGGGCTGC
CACCTGGACTTCACATTAAAGGTTCATGGGCAAGCCACGGGCGAAAAGCTGACTGCCTAT
ACGGCCACCCCTGAAGCCATTTATGGCACCTCCCACGTGGCCATCTCGCCCAGCCACAGA
CTCCTACATGGGCACAGCTCTCTGAAGGAAGCCTTGAGGATGGCCCTTGTCCCTGGCAAA
GATTGCCTCACGCCTGTAATGGCTGTGAACATGCTTACCCAGCAGGAGGTCCCTGTCGTT
ATTTTGGCCAAAGCTGACTTGGAAGGCTCTCTGGATTCAAAAATAGGAATTCCCAGTACT
AGCTCAGAGGACACCATCTTAGCCCAAACCCTGGGCCTGGCCTACTCTGAAGTCATTGAA
ACTTTGCCAGATGGCACAGAGAGACTGAGCAGCTCTGCTGAGTTCACAGGTATGACCCGG
CAGGATGCTTTTCTAGCCCTGACTCAGAAAGCCCGGGGGAAGAGAGTGGGTGGAGACGTG
ACAAGTGATAAACTGAAAGACTGGCTGATTTCACGGCAGCGGTACTGGGGCACACCAATC
CCCATTGTCCACTGCCCAGTCTGTGGCCCCACACCTGTGCCCCTGGAGGACTTGCCTGTG
ACCCTGCCCAACATCGCGTCTTTCACTGGCAAGGGAGGCCCCCCACTGGCCATGGCTTCA
GAGTGGGTGAACTGCTCCTGCCCAAGGTGCAAGGGAGCAGCCAAGAGAGAGACAGACACG
ATGGATACCTTTGTTGATTCTGCTTGGTACTACTTCAGATACACTGACCCTCATAATCCA
CACAGCCCTTTTAACACAGCAGTGGCCGATTACTGGATGCCTGTGGATTTGTACATTGGA
GGGAAAGAACATGCCGTCATGCACTTGTTCTATGCAAGATTCTTTAGTCATTTTTGCCAT
GATCAAAAAATGGTTAAACATAGGGAGCCTTTTCATAAGCTGCTGGCCCAAGGCCTTATC
AAGGGGCAGACATTCCGCCTACCATCTGGACAGTATCTACAGAGAGAGGAAGTGGATCTC
ACAGGTTCCGTTCCTGTTCATGCAAAAACGAAAGAGAAGTTAGAGGTGACGTGGGAGAAG
ATGAGTAAGTCCAAACACAACGGGGTGGACCCAGAGGAAGTTGTGGAGCAGTATGGGATC
GACACGATTCGGCTCTACATCCTTTTTGCTGCCCCTCCTGAGAAGGATATCTTGTGGGAT
GTGAAAACTGATGCTCTCCCTGGGGTGCTGAGATGGCAACAACGACTGTGGACCTTGACA
ACTCGGTTTATTGAGGCCAGGGCTTCTGGGAAGTCTCCCCAGCCTCAGCTGCTGAGTAAC
AAGGAGAAAGCTGAGGCCAGGAAGCTCTGGGAGTACAAGAACTCCGTCATCTCTCAGGTG
ACCACCCATTTCACAGAGGACTTCTCACTGAATTCTGCAATTTCTCAGCTGATGGGACTC
AGCAATGCCCTCTCGCAAGCCTCTCAGAGCGTCATTCTCCACAGCCCCGAGTTTGAGGAT
GCTTTGTGTGCCCTGATGGTAATGGCTGCTCCACTGGCCCCTCATGTAACCTCAGAGATC
TGGGCAGGCCTGGCGCTGGTGCCGAGGAAGCTCTGTGCCCACTACACTTGGGATGCCAGT
GTGCTGCTCCAGGCATGGCCTGCTGTGGACCCGGAGTTCCTGCAGCAGCCTGAGGTTGTC
CAGATGGCAGTTCTGATCAACAATAAAGCTTGTGGCAAAATTCCTGTGCCCCAACAAGTT
GCCCGGGACCAGGACAAAGTCCACGAATTTGTTCTTCAAAGCGAGCTGGGTGTCAGGCTT
TTGCAAGGACGAAGCATCAAGAAGTCCTTCCTTTCCCCGAGAACTGCCCTCATCAACTTC
CTGGTGCAAGATTGA

# Metabolic_Enzyme_48_GenBank_ID_Gene:
D21851

# Metabolic_Enzyme_48_Chromosome_Location:
Not Available

# Metabolic_Enzyme_48_Locus:
Not Available

# Metabolic_Enzyme_48_SNPs:
Not Available

# Metabolic_Enzyme_48_General_References:
7584026

# Metabolic_Enzyme_48_References:
Not Available

# Metabolic_Enzyme_49_ID:
5869

# Metabolic_Enzyme_49_Name:
AMP deaminase 3

# Metabolic_Enzyme_49_Synonyms:
AMP deaminase isoform E; Erythrocyte AMP deaminase

# Metabolic_Enzyme_49_Gene_Name:
AMPD3

# Metabolic_Enzyme_49_Protein_Sequence:
>AMP deaminase 3
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN

# Metabolic_Enzyme_49_Number_of_Residues:
767

# Metabolic_Enzyme_49_Molecular_Weight:
88813

# Metabolic_Enzyme_49_Theoretical_pI:
6.98

# Metabolic_Enzyme_49_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_49_General_Function:
Not Available

# Metabolic_Enzyme_49_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_49_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_49_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_49_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_49_Signals:
None

# Metabolic_Enzyme_49_Transmembrane_Regions:
None

# Metabolic_Enzyme_49_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_49_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_49_GenBank_ID_Protein:
219457

# Metabolic_Enzyme_49_SwissProt_ID:
AMPD3_HUMAN (Q01432)

# Metabolic_Enzyme_49_swissprot_Name:
Not Available

# Metabolic_Enzyme_49_Genecard_id:
AMPD3

# Metabolic_Enzyme_49_Geneatlas_id:
AMPD3

# Metabolic_Enzyme_49_hgnc_id:
HGNC:470

# Metabolic_Enzyme_49_PDB_ID:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_49_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_49_Gene_Sequence:
>2304 bp
ATGCCGCGGCAGTTTCCCAAGCTGAACATCTCTGAAGTGGATGAGCAAGTCCGGCTCCTG
GCGGAGAAGGTGTTTGCTAAAGTGCTCCGAGAAGAGGACAGCAAAGATGCCCTGTCCCTG
TTCACTGTCCCAGAGGACTGCCCCATCGGGCAAAAGGAAGCCAAGGAGAGGGAGCTGCAG
AAGGAGCTGGCAGAGCAGAAGTCTGTGGAGACCGCAAAAAGAAAGAAAAGTTTCAAGATG
ATTCGGTCCCAGTCCCTGTCTCTGCAAATGCCGCCACAGCAAGATTGGAAGGGCCCCCCG
GCAGCCAGTCCGGCCATGTCTCCCACAACCCCTGTGGTCACTGGAGCCACTTCCCTGCCC
ACGCCAGCACCCTATGCCATGCCTGAGTTCCAGCGGGTCACCATCAGCGGAGATTACTGT
GCCGGGATCACTTTGGAGGACTATGAGCAGGCAGCCAAGAGTCTGGCCAAGGCCCTAATG
ATCCGGGAGAAGTATGCGCGGCTCGCCTACCACCGCTTCCCGCGGATCACATCCCAGTAC
CTGGGTCATCCGCGGGCGGATACTGCACCTCCGGAAGAGGGCCTTCCAGACTTCCACCCT
CCTCCACTGCCCCAGGAAGACCCCTACTGCCTGGATGATGCACCCCCCAACCTGGATTAC
TTGGTCCACATGCAGGGGGGCATCCTCTTTGTGTATGATAACAAGAAGATGCTGGAGCAC
CAGGAGCCGCACAGCCTACCCTACCCCGACCTGGAGACCTACACGGTGGACATGAGCCAC
ATCCTGGCTCTCATCACCGATGGCCCCACGAAAACCTATTGTCACCGGCGACTGAACTTT
CTGGAATCCAAGTTCAGCCTTCATGAGATGTTAAACGAAATGTCCGAGTTCAAAGAGTTG
AAGAGTAACCCCCACCGGGACTTCTATAACGTGAGAAAGGTGGACACACACATCCATGCG
GCCGCCTGCATGAACCAAAAGCATCTGCTGCGCTTCATCAAGCACACATACCAGACGGAG
CCTGACAGGACTGTGGCAGAGAAGCGGGGCCGGAAGATCACCCTGCGGCAGGTGTTTGAC
GGCCTGCACATGGACCCCTACGACCTCACTGTGGACTCACTGGATGTCCACGCGGGCCGG
CAGACATTCCACCGCTTTGACAAGTTCAACTCCAAATACAACCCTGTGGGGGCCAGTGAG
CTGCGTGACCTGTATTTGAAAACTGAAAACTATCTGGGAGGAGAGTACTTTGCTCGGATG
GTCAAGGAGGTTGCCCGGGAGCTGGAGGAGAGCAAGTACCAGTACTCAGAGCCACGGCTC
TCCATCTACGGCCGCAGTCCTGAGGAGTGGCCCAACCTGGCCTACTGGTTCATCCAGCAC
AAGGTCTACTCTCCCAACATGCGCTGGATCATCCAGGTGCCCCGGATTTATGACATATTT
AGGTCAAAGAAGCTGCTGCCAAACTTTGGGAAGATGCTGGAGAACATCTTCCTGCCCCTT
TTCAAGGCCACTATCAACCCCCAAGATCATCGAGAGCTTCACCTCTTCCTTAAATATGTG
ACGGGGTTTGACAGCGTGGATGATGAGTCCAAGCACAGCGACCACATGTTTTCCGACAAG
AGCCCAAACCCGGACGTCTGGACCAGTGAGCAGAACCCACCCTACAGCTACTACCTGTAC
TACATGTATGCCAACATCATGGTGCTCAACAACCTCCGCAGGGAGCGCGGCCTGAGCACG
TTCCTGTTCCGGCCGCACTGTGGGGAAGCCGGCTCCATCACCCACCTGGTGTCTGCCTTC
CTCACTGCTGACAACATTTCCCACGGGCTGCTCCTCAAGAAGAGTCCGGTATTGCAGTAT
CTCTACTACCTTGCTCAGATCCCCATTGCCATGTCTCCTCTTAGCAACAACAGTTTGTTC
CTCGAATATTCCAAGAACCCTCTGAGGGAATTCCTACACAAGGGACTGCATGTTTCTCTT
TCCACCGATGACCCCATGCAGTTCCACTACACGAAGGAAGCACTTATGGAAGAATATGCC
ATTGCAGCTCAAGTGTGGAAGCTGAGCACCTGCGACCTGTGTGAGATCGCCAGGAACAGC
GTGCTGCAGAGCGGCCTCTCGCATCAGGAAAAGCAAAAGTTTCTGGGACAAAATTATTAT
AAAGAAGGACCTGAAGGAAATGATATTCGAAAGACAAATGTGGCTCAGATCCGGATGGCA
TTCCGATATGAGACCTTATGCAATGAGCTCAGCTTCCTGTCTGATGCTATGAAATCAGAA
GAGATCACCGCCTTGACCAACTAG

# Metabolic_Enzyme_49_GenBank_ID_Gene:
D12775

# Metabolic_Enzyme_49_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_49_Locus:
11p15

# Metabolic_Enzyme_49_SNPs:
rs11042836; rs36003153; rs3741041; rs16907852; rs34319136; rs11820856; rs899013; rs899011; rs899010; rs1037998; rs936513; rs936514; rs9292; rs1545743; rs7109334; rs11822997; rs930672; rs7416; rs2071020; rs7123980; rs7124144; rs2071019; rs1466426; rs2071018; rs7113101; rs1001118; rs7122280; rs11042840; rs10840419; rs3741037; rs10437597; rs10840427; rs3891547; rs2071017; rs11826750; rs10840429; rs11042854; rs12419888; rs12795565; rs11042830; rs10770120; rs11042841; rs3802917; rs11042846; rs3741038; rs11602933; rs11042853; rs7943804; rs11042849; rs17401498; rs7105307; rs11601268; rs7128132; rs12271597; rs11042855; rs11042833; rs4910146; rs7107588; rs7125606; rs12416948; rs6484336; rs4910140; rs10840424; rs11042850; rs16907878; rs11042842; rs10840425; rs11042834; rs16907858; rs11042828; rs11042848; rs899014; rs11042856; rs7127884; rs1466427; rs7124537; rs10770122; rs7934278; rs2071016; rs7125888; rs10840431; rs4910143; rs11042832; rs11042851; rs12800954; rs12284970; rs4910141; rs11042864; rs6484302; rs7934815; rs11042839; rs16907891; rs12421214; rs16907836; rs16907914; rs16907919; rs10840428; rs3741043; rs7110563; rs3741039; rs11042831; rs4910144; rs4909930; rs10770119; rs7114333; rs17310342; rs11042852; rs12290824; rs7949917; rs10840420; rs11042859; rs11042843; rs7944154; rs4909932; rs10840430; rs11042847; rs16907868; rs7101748; rs10840422; rs922360; rs10770118; rs10840421; rs16907909; rs16907896; rs7130140; rs16907917; rs7101934; rs11042835; rs12418145; rs11042844; rs11042863; rs10840423; rs7932321; rs4909931; rs7950039; rs4909928; rs7929999; rs4909929; rs7111970; rs12161765; rs6484290; rs7112321; rs6484291; rs4910139; rs3741040; rs12418097; rs1803101; rs416372; rs11278140; rs10592594; rs34205084; rs10666578; rs376859; rs35285382; rs35234722; rs34276239; rs2403330; rs433847; rs35548473; rs922359; rs35027484; rs5029459; rs34686247; rs11042817; rs2169594; rs36117985; rs28403593; rs12360830; rs35815414; rs28403594; rs35417007; rs34947038; rs11042816; rs34448488; rs34793322; rs11455471; rs7120456; rs12804742; rs35753139; rs12789944; rs12295824; rs35307925; rs35469290; rs11042827; rs11042815; rs12285554; rs10770121; rs11042837; rs10437667; rs389793; rs4909933; rs12291731; rs411593; rs12291443; rs7937616; rs11042857; rs12295125; rs5789638; rs11042813; rs34796012; rs34400211; rs10466517; rs11327316; rs35172583; rs12284303; rs10466406; rs12287821; rs36106536; rs7107965; rs11042812; rs35535464; rs36075284; rs12271609; rs446512; rs11042826; rs10466515; rs12221503; rs12293113; rs10840426; rs11042845; rs10743142; rs11042862; rs403952; rs34388590; rs34972496; rs34843534; rs12790244; rs7119606; rs11522665; rs10466514; rs12292471; rs35410520; rs12575256; rs12786914; rs12224969; rs12287504; rs35022461; rs35501680; rs34957142; rs4910142; rs12184411; rs11042860; rs16907904; rs35803105; rs34769794; rs34045306; rs35148074; rs11346179; rs11042838; rs34159907; rs4910147; rs11279688; rs34735568; rs35724616; rs10466404; rs35916834; rs7937988; rs35909829; rs12803441; rs4909934; rs4369398; rs7951269; rs11042861; rs34779745; rs34942282; rs11530493; rs11820349; rs9736934; rs11042829; rs35114038; rs10466516; rs12802491; rs12284175; rs10709823; rs11042818; rs36119682; rs35629432; rs11042858; rs12291294; rs34456454; rs36120251; rs11042814; rs11042811; rs11042825; rs36032769; rs7107565; rs7937289; rs7107698; rs7124271; rs10643285; rs36206458; rs8181594; rs7938316; rs11042810; rs10590775; rs1043778; rs10500725; rs1074375; rs10770123; rs10840415; rs10840416; rs10840417; rs10840418; rs11042805; rs11042806; rs11042865; rs11042866; rs11042867; rs11042868; rs11602469; rs11607008; rs12164827; rs12225339; rs12280618; rs12290357; rs12363993; rs12448; rs12789639; rs16907826; rs1870951; rs3177103; rs3741036; rs374925; rs382044; rs383090; rs394242; rs411783; rs4146830; rs428325; rs446762; rs4910149; rs4910150; rs570362; rs6484281; rs677322; rs7119498; rs7939845; rs7948437; rs899012; rs9971562

# Metabolic_Enzyme_49_General_References:
1420359; 1400401; 8611627; 8004104

# Metabolic_Enzyme_49_References:
Not Available

# Metabolic_Enzyme_50_ID:
5870

# Metabolic_Enzyme_50_Name:
Ubiquitin-conjugating enzyme E2 J2

# Metabolic_Enzyme_50_Synonyms:
Non-canonical ubiquitin-conjugating enzyme 2; NCUBE2

# Metabolic_Enzyme_50_Gene_Name:
UBE2J2

# Metabolic_Enzyme_50_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 J2
MNSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGY
YHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLS
FMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSR
PQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIV
GFAAFAYTVKYVLRSIAQE

# Metabolic_Enzyme_50_Number_of_Residues:
259

# Metabolic_Enzyme_50_Molecular_Weight:
28926

# Metabolic_Enzyme_50_Theoretical_pI:
8.59

# Metabolic_Enzyme_50_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_50_General_Function:
Not Available

# Metabolic_Enzyme_50_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum

# Metabolic_Enzyme_50_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_50_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_50_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_50_Signals:
None

# Metabolic_Enzyme_50_Transmembrane_Regions:
227-247

# Metabolic_Enzyme_50_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_50_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_50_GenBank_ID_Protein:
14029267

# Metabolic_Enzyme_50_SwissProt_ID:
UB2J2_HUMAN (Q8N2K1)

# Metabolic_Enzyme_50_swissprot_Name:
Not Available

# Metabolic_Enzyme_50_Genecard_id:
UBE2J2

# Metabolic_Enzyme_50_Geneatlas_id:
UBE2J2

# Metabolic_Enzyme_50_hgnc_id:
HGNC:19268

# Metabolic_Enzyme_50_PDB_ID:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_50_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type IV membrane protein

# Metabolic_Enzyme_50_Gene_Sequence:
>777 bp
ATGAGCAGCACCAGCAGTAAGAGGGCTCCGACCACGGCAACCCAGAGGCTGAAGCAGGAC
TACCTTCGCATTAAGAAAGACCCGGTGCCTTACATCTGTGCCGAGCCCCTCCCTTCGAAT
ATTCTCGAGTGGCACTATGTCGTCCGAGGCCCAGAGATGACCCCTTATGAAGGTGGCTAT
TATCATGGAAAACTAATTTTTCCCAGAGAATTTCCTTTCAAACCTCCCAGTATCTATATG
ATCACTCCCAACGGGAGGTTTAAGTGCAACACCAGGCTGTGTCTTTCTATCACGGATTTC
CACCCGGACACGTGGAACCCGGCCTGGTCTGTCTCCACCATCCTGACTGGGCTCCTGAGC
TTCATGGTGGAGAAGGGCCCCACCCTGGGCAGTATAGAGACGTCGGACTTCACGAAAAGA
CAACTGGCAGTGCAGAGTTTAGCATTTAATTTGAAAGATAAAGTCTTTTGTGAATTATTT
CCTGAAGTCGTGGAGGAGATTAAACAAAAACAGAAAGCACAAGACGAACTCAGTAGCAGA
CCCCAGACTCTCCCCTTGCCAGACGTGGTTCCAGACGGGGAGACGCACCTCGTCCAGAAC
GGGATTCAGCTGCTCAACGGGCATGCGCCGGGGGCCGTCCAAACCTCGCAGGGCTCCAGC
AGGCCAACCGGCACCACGGACTCTGGGTGGCGCCCTGGCGAACTTGTTTGTATAGTTGGG
TTTGCAGCCTTTGCTTACACGGTCAAGTACGTGCTGAGGAGCATCGCGCAGGAGTGA

# Metabolic_Enzyme_50_GenBank_ID_Gene:
AF296658

# Metabolic_Enzyme_50_Chromosome_Location:
Not Available

# Metabolic_Enzyme_50_Locus:
Not Available

# Metabolic_Enzyme_50_SNPs:
Not Available

# Metabolic_Enzyme_50_General_References:
11278356

# Metabolic_Enzyme_50_References:
Not Available

# Metabolic_Enzyme_51_ID:
5871

# Metabolic_Enzyme_51_Name:
AMP deaminase 2

# Metabolic_Enzyme_51_Synonyms:
AMP deaminase isoform L

# Metabolic_Enzyme_51_Gene_Name:
AMPD2

# Metabolic_Enzyme_51_Protein_Sequence:
>AMP deaminase 2
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAAVVPAMASYPS
GSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMD
GKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLR
AKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDA
AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVN
VLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIH
ASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHAD
RNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELR
LSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYL
YYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQ
YLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY
SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRV
GYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ

# Metabolic_Enzyme_51_Number_of_Residues:
879

# Metabolic_Enzyme_51_Molecular_Weight:
100689

# Metabolic_Enzyme_51_Theoretical_pI:
6.93

# Metabolic_Enzyme_51_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_51_General_Function:
Not Available

# Metabolic_Enzyme_51_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_51_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_51_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_51_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_51_Signals:
None

# Metabolic_Enzyme_51_Transmembrane_Regions:
None

# Metabolic_Enzyme_51_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_51_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_51_GenBank_ID_Protein:
644509

# Metabolic_Enzyme_51_SwissProt_ID:
AMPD2_HUMAN (Q01433)

# Metabolic_Enzyme_51_swissprot_Name:
Not Available

# Metabolic_Enzyme_51_Genecard_id:
AMPD2

# Metabolic_Enzyme_51_Geneatlas_id:
AMPD2

# Metabolic_Enzyme_51_hgnc_id:
HGNC:469

# Metabolic_Enzyme_51_PDB_ID:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_51_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_51_Gene_Sequence:
>2263 bp
CGCCGAGGAGCTGTTCACCCGCTCACTGGCTGAGAGCGAGCTCCGTAGTGCCCCGTATGA
GTTCCCCGAGGAGAGCCCCATTGAACAGCTGGAGGAGCGGCGGCAGCGGCTGGAGCGGCA
GATCAGCCAGGATGTCAAGCTGGAGCCAGACATCCTGCTTCGGGCCAAGCAAGATTTCCT
GAAGACGGACAGTGACTCGGACCTACAGCTCTACAAGGAACAGGGTGAGGGGCAGGGTGA
CCGGAGCCTGCGGGAGCGTGATGTGCTGGAACGGGAGTTTCAGCGGGTCACCATCTCTGG
GGAGGAGAAGTGTGGGGTGCCGTTCACAGACCTGCTGGATGCAGCCAAGAGTGTGGTGCG
GGCGCTCTTCATCCGGGAGAAGTACATGGCCCTGTCCCTGCAGAGCTTCTGCCCCACCAC
CCGCCGCTACCTGCAGCAGCTGGCTGAAAAGCCTCTGGAGACCCGGACCTATGAACAGGG
CCCCGACACCCCTGTGTCTGCTGATGCCCCGGTGCACCCCCCTGCGCTGGAGCAGCACCC
GTATGAGCACTGTGAGCCAAGCACCATGCCTGGGGACCTGGGCTTGGGTCTGCGCATGGT
GCGGGGTGTGGTGCACGTCTACACCCGCAGGGAACCCGACGAGCATTGCTCAGAGGTGGA
GCTGCCATACCCTGACCTGCAGGAATTTGTGGCTGACGTCAATGTGCTGATGGCCCTGAT
TATCAATGGCCCCATAAAGTCATTCTGCTACCGCCGGCTGCAGTACCTGAGCTCCAAGTT
CCAGATGCATGTGCTACTCAATGAGATGAAGGAGCTGGCCGCCCAGAAGAAAGTGCCACA
CCGAGATTTCTACAACATCCGCAAGGTGGACACCCACATCCATGCCTCGTCCTGCATGAA
CCAGAAGCATCTGCTGCGCTTCATCAAGCGGGCAATGAAGCGGCACCTGGAGGAGATCGT
GCACGTGGAGCAGGGCCGTGAACAGACGCTGCGGGAGGTCTTTGAGAGCATGAATCTCAC
GGCCTACGACCTGAGTGTGGACACGCTGGATGTGCATGCGGACAGGAACACTTTCCATCG
CTTTGACAAGTTTAATGCCAAATACAACCCTATTGGGGAGTCCGTCCTCCGAGAGATCTT
CATCAAGACGGACAACAGGGTATCTGGGAAGTACTTTGCTCACATCATCAAGGAGGTGAT
GTCAGACCTGGAGGAGAGCAAATACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCG
CTCGAGGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGCGTGCACTCCCC
CAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCA
GCTGGCCAACTTCCAGGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGT
GCACCCTGCCAGCCACCCGGAACTGCATCTCTTCTTAGAGCACGTGGATGGTTTTGACAG
CGTGGATGATGAGTCCAAGCCTGAAAACCATGTCTTCAACCTGGAGAGCCCCCTGCCTGA
GGCGTGGGTGGAGGAGGACAACCCACCCTATGCCTACTACCTGTACTACACCTTTGCCAA
CATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGGCTTCCACACGTTTGTGCTGAGGCC
ACACTGTGGGGAGGCTGGGCCCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAA
CATTTCCCACGGGCTCCTTCTGCGCAAGGCCCCCGTCCTGCAGTACCTGTACTACCTGGC
CCAGATCGGCATCGCCATGTCTCCGCTCAGCAACAACAGCCTCTTCCTCAGCTATCACCG
GAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCC
CTTGCAGTTCCACTTCACCAAGGAGCCGCTGATGGAGGAGTACAGCATCGCCACCCAGGT
GTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCCGCAACAGCGTGCTCATGAGCGG
CTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCCTGA
GGGGAATGACATCCGCCGGACCAATGTGCCAGACATCCGCGTGGGCTACCGCTACGAGAC
CCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCAT
TCCAGAGGAGGCGGGTATCACCATGAGCCCAGGGCCTCAATGA

# Metabolic_Enzyme_51_GenBank_ID_Gene:
M91029

# Metabolic_Enzyme_51_Chromosome_Location:
Not Available

# Metabolic_Enzyme_51_Locus:
Not Available

# Metabolic_Enzyme_51_SNPs:
Not Available

# Metabolic_Enzyme_51_General_References:
1429593; 8526848; 8764830

# Metabolic_Enzyme_51_References:
Not Available

# Metabolic_Enzyme_52_ID:
5872

# Metabolic_Enzyme_52_Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

# Metabolic_Enzyme_52_Synonyms:
Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A

# Metabolic_Enzyme_52_Gene_Name:
PDE3A

# Metabolic_Enzyme_52_Protein_Sequence:
>cGMPinhibited 3',5'cyclic phosphodiesterase 
AMAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSR
KLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGA
PGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLG
VGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPY
LAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAE
MSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITD
LLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKL
AIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSW
NNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLV
SKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPAD
EPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTY
APETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLF
EDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVI
NDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRF
LVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKE
LHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSA
GLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHL
LQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKP
DQ

# Metabolic_Enzyme_52_Number_of_Residues:
1141

# Metabolic_Enzyme_52_Molecular_Weight:
124980

# Metabolic_Enzyme_52_Theoretical_pI:
5.87

# Metabolic_Enzyme_52_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_52_General_Function:
Not Available

# Metabolic_Enzyme_52_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_52_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_52_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_52_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_52_Signals:
None

# Metabolic_Enzyme_52_Transmembrane_Regions:
61-83; 129-151; 158-180; 184-206; 238-255

# Metabolic_Enzyme_52_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_52_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_52_GenBank_ID_Protein:
38201493

# Metabolic_Enzyme_52_SwissProt_ID:
PDE3A_HUMAN (Q14432)

# Metabolic_Enzyme_52_swissprot_Name:
Not Available

# Metabolic_Enzyme_52_Genecard_id:
PDE3A

# Metabolic_Enzyme_52_Geneatlas_id:
PDE3A

# Metabolic_Enzyme_52_hgnc_id:
HGNC:8778

# Metabolic_Enzyme_52_PDB_ID:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_52_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_52_Gene_Sequence:
>3426 bp
ATGGCAGTGCCCGGCGACGCTGCACGAGTCAGGGACAAGCCCGTCCACAGTGGGGTGAGT
CAAGCCCCCACGGCGGGCCGGGACTGCCACCATCGTGCGGACCCCGCATCGCCGCGGGAC
TCGGGCTGCCGTGGCTGCTGGGGAGACCTGGTGCTGCAGCCGCTCCGGAGCTCTCGGAAA
CTTTCCTCCGCGCTGTGCGCGGGCTCCCTATCCTTTCTGCTGGCGCTGCTGGTGAGGCTG
GTCCGCGGGGAGGTCGGCTGTGACCTGGAGCAGTGTAAGGAGGCGGCGGCGGCGGAGGAG
GAGGAAGCAGCCCCGGGAGCAGAAGGGGGCGTCTTCCCGGGGCCTCGGGGAGGTGCTCCC
GGGGGCGGTGCGCGGCTCAGCCCCTGGCTGCAGCCCTCGGCGCTGCTCTTCAGTCTCCTG
TGTGCCTTCTTCTGGATGGGCTTGTACCTCCTGCGCGCCGGGGTGCGCCTGCCTCTGGCT
GTCGCGCTGCTGGCCGCCTGCTGCGGGGGGGAAGCGCTCGTCCAGATTGGGCTGGGCGTC
GGGGAGGATCACTTACTCTCACTCCCCGCTGCGGGGGTGGTGCTCAGCTGCTTGGCCGCC
GCGACATGGCTGGTGCTGAGGCTGAGGCTGGGCGTCCTCATGATCGCCTTGACTAGCGCG
GTCAGGACCGTGTCCCTCATTTCCTTAGAGAGGTTCAAGGTCGCCTGGAGACCTTACCTG
GCGTACCTGGCCGGCGTGCTGGGGATCCTCTTGGCCAGGTACGTGGAACAAATCTTGCCG
CAGTCCGCGGAGGCGGCTCCAAGGGAGCATTTGGGGTCCCAGCTGATTGCTGGGACCAAG
GAAGATATCCCGGTGTTTAAGAGGAGGAGGCGGTCCAGCTCCGTCGTGTCCGCCGAGATG
TCCGGCTGCAGCAGCAAGTCCCATCGGAGGACCTCCCTGCCCTGTATACCGAGGGAACAG
CTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGA
ACCAGTATTACTGTGGACATCGCCGTCATGGGCGAAGCCCACGGCCTCATTACCGACCTC
CTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTG
CTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTTACTTCG
CTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCT
ATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACT
TGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGA
GACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAAT
AATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCT
GCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCA
CCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGC
AAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGT
TCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACT
CCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAG
CCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTCGAACAGATGACACTGCTCAA
GTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAA
GATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCT
CCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGAT
AACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTG
GAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAA
GACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCAT
GCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTT
TTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAAT
GATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGA
TATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAAT
ATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCAT
CCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAAC
GATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGG
CCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTT
GTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTT
AATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTG
GTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTC
CATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCC
AGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTT
CAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGA
CTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAA
GAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCT
CCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTA
CAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAA
AATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAG
GAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGAC
CAGTGA

# Metabolic_Enzyme_52_GenBank_ID_Gene:
M91667

# Metabolic_Enzyme_52_Chromosome_Location:
Not Available

# Metabolic_Enzyme_52_Locus:
Not Available

# Metabolic_Enzyme_52_SNPs:
Not Available

# Metabolic_Enzyme_52_General_References:
1315035; 8695850

# Metabolic_Enzyme_52_References:
Not Available

# Metabolic_Enzyme_53_ID:
5873

# Metabolic_Enzyme_53_Name:
Ubiquitin-conjugating enzyme E2 L3

# Metabolic_Enzyme_53_Synonyms:
Ubiquitin-protein ligase L3; Ubiquitin carrier protein L3; UbcH7; E2-F1; L-UBC

# Metabolic_Enzyme_53_Gene_Name:
UBE2L3

# Metabolic_Enzyme_53_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 L3
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD

# Metabolic_Enzyme_53_Number_of_Residues:
154

# Metabolic_Enzyme_53_Molecular_Weight:
17862

# Metabolic_Enzyme_53_Theoretical_pI:
8.79

# Metabolic_Enzyme_53_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_53_General_Function:
Not Available

# Metabolic_Enzyme_53_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_53_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_53_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_53_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_53_Signals:
None

# Metabolic_Enzyme_53_Transmembrane_Regions:
None

# Metabolic_Enzyme_53_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_53_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_53_GenBank_ID_Protein:
1488377

# Metabolic_Enzyme_53_SwissProt_ID:
UB2L3_HUMAN (P68036)

# Metabolic_Enzyme_53_swissprot_Name:
Not Available

# Metabolic_Enzyme_53_Genecard_id:
UBE2L3

# Metabolic_Enzyme_53_Geneatlas_id:
UBE2L3

# Metabolic_Enzyme_53_hgnc_id:
HGNC:12488

# Metabolic_Enzyme_53_PDB_ID:
1FBV

# Metabolic_Enzyme_53_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_53_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_53_Subcellular_Location:
Not Available

# Metabolic_Enzyme_53_Gene_Sequence:
>465 bp
ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAA
AACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTT
CCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG
TACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGAC
GAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAA
ACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCG
CTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT
GAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA

# Metabolic_Enzyme_53_GenBank_ID_Gene:
S81003

# Metabolic_Enzyme_53_Chromosome_Location:
Not Available

# Metabolic_Enzyme_53_Locus:
Not Available

# Metabolic_Enzyme_53_SNPs:
Not Available

# Metabolic_Enzyme_53_General_References:
8563171; 8576257; 9693040; 8144544; 10760570; 10558980; 10966114; 12612082

# Metabolic_Enzyme_53_References:
Not Available

# Metabolic_Enzyme_54_ID:
5874

# Metabolic_Enzyme_54_Name:
RNA 3'-terminal phosphate cyclase

# Metabolic_Enzyme_54_Synonyms:
RNA-3'-phosphate cyclase; RNA cyclase

# Metabolic_Enzyme_54_Gene_Name:
RTCD1

# Metabolic_Enzyme_54_Protein_Sequence:
>RNA 3'terminal phosphate cyclase
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIR
DLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELH
LKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNP
INLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAF
GNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLI
VFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIG
MTNPNL

# Metabolic_Enzyme_54_Number_of_Residues:
366

# Metabolic_Enzyme_54_Molecular_Weight:
39337

# Metabolic_Enzyme_54_Theoretical_pI:
7.94

# Metabolic_Enzyme_54_GO_Classification:
>>>
Function:  catalytic activity
Function:  cyclase activity
Function:  RNA-3'-phosphate cyclase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_54_General_Function:
RNA processing and modification 

# Metabolic_Enzyme_54_Specific_Function:
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

# Metabolic_Enzyme_54_Pathway:
Not Available

# Metabolic_Enzyme_54_Reaction:
ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

# Metabolic_Enzyme_54_Pfam_Domain_Function:
PF01137:RTC;
PF05189:RTC_insert

# Metabolic_Enzyme_54_Signals:
None

# Metabolic_Enzyme_54_Transmembrane_Regions:
None

# Metabolic_Enzyme_54_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_54_EC_Link:
EC 6.5.1.4

# Metabolic_Enzyme_54_GenBank_ID_Protein:
2125812

# Metabolic_Enzyme_54_SwissProt_ID:
RTC1_HUMAN (O00442)

# Metabolic_Enzyme_54_swissprot_Name:
Not Available

# Metabolic_Enzyme_54_Genecard_id:
RTCD1

# Metabolic_Enzyme_54_Geneatlas_id:
RTCD1

# Metabolic_Enzyme_54_hgnc_id:
HGNC:17981

# Metabolic_Enzyme_54_PDB_ID:
Not Available

# Metabolic_Enzyme_54_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_54_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_54_Subcellular_Location:
Nucleus; nucleoplasm

# Metabolic_Enzyme_54_Gene_Sequence:
>1101 bp
ATGGCGGGGCCGCGGGTGGAGGTCGATGGCAGCATCATGGAAGGGGGCGGCCAGATCCTG
AGAGTCTCTACGGCCTTGAGCTGTCTCCTAGGCCTCCCCTTGCGGGTGCAGAAGATCCGA
GCCGGCCGGAGCACGCCAGGCCTGAGGCCTCAACATTTATCTGGACTGGAAATGATTCGA
GATTTGTGTGATGGGCAACTGGAGGGGGCAGAAATTGGCTCAACAGAAATAACCTTTACA
CCAGAGAAGATCAAAGGTGGAATCCACACAGCAGATACCAAGACAGCAGGGAGTGTGTGC
CTCTTGATGCAGGTCTCAATGCCGTGTGTTCTCTTTGCTGCTTCTCCATCAGAACTTCAT
TTGAAAGGTGGAACTAATGCTGAAATGGCACCACAGATCGATTATACAGTGATGGTCTTC
AAGCCAATTGTTGAAAAATTTGGTTTCATATTTAATTGTGACATTAAAACAAGGGGATAT
TACCCAAAAGGGGGTGGTGAAGTGATTGTTCGAATGTCACCAGTTAAACAATTGAACCCT
ATAAATTTAACTGAGCGTGGCTGTGTGACTAAGATATATGGAAGAGCTTTCGTTGCTGGT
GTTTTGCCATTTAAAGTAGCAAAAGATATGGCAGCGGCAGCAGTTAGATGCATCAGAAAG
GAGATCCGGGATTTGTATGTTAACATCCAGCCTGTTCAAGAACCTAAAGACCAAGCATTT
GGCAATGGAAATGGAATAATAATTATTGCTGAGACCTCCACTGGCTGTTTGTTTGCTGGA
TCATCGCTTGGTAAACGAGGTGTAAATGCAGACAAAGTTGGAATTGAAGCTGCCGAAATG
CTATTAGCAAATCTTAGACATGGTGGTACTGTGGATGAGTATCTGCAAGACCAGCTGATT
GTTTTCATGGCATTAGCCAATGGAGTTTCCAGAATAAAAACAGGACCAGTTACACTCCAT
ACGCAAACCGCGATACATTTTGCTGAACAAATAGCAAAGGCTAAATTTATTGTGAAGAAA
TCAGAAGATGAAGAAGACGCCGCTAAAGATACTTATATTATTGAATGCCAAGGAATTGGG
ATGACAAATCCAAATCTATAG

# Metabolic_Enzyme_54_GenBank_ID_Gene:
Y11651

# Metabolic_Enzyme_54_Chromosome_Location:
Not Available

# Metabolic_Enzyme_54_Locus:
Not Available

# Metabolic_Enzyme_54_SNPs:
Not Available

# Metabolic_Enzyme_54_General_References:
9184239; 2199762

# Metabolic_Enzyme_54_References:
Not Available

# Metabolic_Enzyme_55_ID:
5875

# Metabolic_Enzyme_55_Name:
Putative adenylate kinase 7

# Metabolic_Enzyme_55_Synonyms:
Not Available

# Metabolic_Enzyme_55_Gene_Name:
AK7

# Metabolic_Enzyme_55_Protein_Sequence:
>Putative adenylate kinase 7
MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENK
SAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNIT
ESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRR
RKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPAL
PVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGK
IQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYK
QSRGLMPIKICILGPPAVGKSSIAKELAKYYKLHHIQLKDVISEAIAKLEAIVAPNDVGE
GEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYIL
DGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPE
SIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQ
LIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNK
RLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNP
EAQ

# Metabolic_Enzyme_55_Number_of_Residues:
723

# Metabolic_Enzyme_55_Molecular_Weight:
82673

# Metabolic_Enzyme_55_Theoretical_pI:
4.40

# Metabolic_Enzyme_55_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_55_General_Function:
Not Available

# Metabolic_Enzyme_55_Specific_Function:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_55_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_55_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_55_Pfam_Domain_Function:
PF05186:Dpy-30

# Metabolic_Enzyme_55_Signals:
None

# Metabolic_Enzyme_55_Transmembrane_Regions:
None

# Metabolic_Enzyme_55_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_55_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_55_GenBank_ID_Protein:
16553126

# Metabolic_Enzyme_55_SwissProt_ID:
KAD7_HUMAN (Q96M32)

# Metabolic_Enzyme_55_swissprot_Name:
Not Available

# Metabolic_Enzyme_55_Genecard_id:
AK7

# Metabolic_Enzyme_55_Geneatlas_id:
AK7

# Metabolic_Enzyme_55_hgnc_id:
HGNC:20091

# Metabolic_Enzyme_55_PDB_ID:
Not Available

# Metabolic_Enzyme_55_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_55_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_55_Subcellular_Location:
Not Available

# Metabolic_Enzyme_55_Gene_Sequence:
>2172 bp
ATGGCTGAAGAAGAGGAAACTGCTGCTCTCACGGAGAAGGTTATCCGGACCCAGAGGGTG
TTTATAAACCTGTTGGATTCCTACAGCAGCGGAAACATCGGGAAGTTTCTATCTAACTGT
GTAGTTGGGGCTTCGCTTGAAGAAATTACAGAGGAAGAGGAAGAGGAAGATGAAAATAAG
TCAGCTATGCTGGAAGCTTCCTCAACCAAAGTGAAGGAAGGCACATTCCAGATTGTGGGC
ACGCTGTCCAAGCCTGACAGCCCGCGGCCTGACTTTGCGGTGGAGACGTACTCTGCCATC
TCTCAAGAAGACCTTCTCATGCGCCTGCTGGAGTGTGATGTTATTATTTATAACATCACT
GAGAGCTCACAGCAAATGGAGGAAGCCATCTGGGCAGTCTCTGCACTCAGTGAAGAAGTC
AGCCACTTTGAAAAGCGAAAGCTATTTATTTTACTGTCGACGGTGATGACTTGGGCGCGC
TCCAAAGCCCTGGACCCCGAGGATTCTGAGGTTCCATTCACTGAAGAAGATTATCGAAGA
AGAAAGTCTCATCCTAATTTTCTGGACCACATAAATGCTGAAAAAATGGTTCTCAAATTT
GGAAAAAAGGCCAGAAAATTTGCAGCATACGTAGTTGCTGCTGGACTCCAGTATGGAGCG
GAAGGAGGCATGTTACACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTA
CCAGTTTTTGGCGATGGAACAAATGTAATTCCAACAATCCATGTTCTTGATCTAGCAGGA
GTGATACAAAACGTCATAGATCACGTGCCAAAGCTTCACTACCTGGTTGCTGTGGATGAG
TCTGTTCATACCCTGGAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAA
ATCCAGAAAATACCCAGAGAAAATGCATACCTAACCAAGGACTTAACGCAAGATTGTCTT
GACCATTTACTGGTCAACTTAAGAATGGAAGCGCTCTTTGTGAAGGAGAATTTTAATATT
CGATGGGCTGCCCAAACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAG
CAAAGCAGAGGATTGATGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAA
TCCAGTATTGCTAAAGAATTGGCCAAGTACTACAAACTGCATCACATCCAACTGAAGGAT
GTCATTTCTGAAGCCATAGCAAAACTGGGGGCGATTGTTGCCCCTAACGATGTAGGGGAA
GGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTC
CTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATA
ATTAGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTG
GATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAG
GAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTC
GTTTGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAG
AGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTAC
CGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCAC
CCGATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAG
CTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAA
GAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGC
GAGCACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAA
CGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTG
AGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGC
AACGTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCT
GAAGCACAGTGA

# Metabolic_Enzyme_55_GenBank_ID_Gene:
AK057426

# Metabolic_Enzyme_55_Chromosome_Location:
Not Available

# Metabolic_Enzyme_55_Locus:
Not Available

# Metabolic_Enzyme_55_SNPs:
Not Available

# Metabolic_Enzyme_55_General_References:
12508121

# Metabolic_Enzyme_55_References:
Not Available

# Metabolic_Enzyme_56_ID:
5876

# Metabolic_Enzyme_56_Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

# Metabolic_Enzyme_56_Synonyms:
Not Available

# Metabolic_Enzyme_56_Gene_Name:
PDE10A

# Metabolic_Enzyme_56_Protein_Sequence:
>cAMP and cAMPinhibited cGMP 3',5'cyclic phosphodiesterase 10
AMRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESA
PKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGE
CNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGL
ESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQV
CRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKEL
YSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY
TGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH
RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGI
FVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFT
DLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHN
IFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLM
MTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGF
YNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED


# Metabolic_Enzyme_56_Number_of_Residues:
779

# Metabolic_Enzyme_56_Molecular_Weight:
88413

# Metabolic_Enzyme_56_Theoretical_pI:
6.57

# Metabolic_Enzyme_56_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_56_General_Function:
Not Available

# Metabolic_Enzyme_56_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This enzyme can hydrolyze both cAMP and cGMP, having a higher affinity for cAMP

# Metabolic_Enzyme_56_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_56_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_56_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_56_Signals:
None

# Metabolic_Enzyme_56_Transmembrane_Regions:
None

# Metabolic_Enzyme_56_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_56_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_56_GenBank_ID_Protein:
4958858

# Metabolic_Enzyme_56_SwissProt_ID:
PDE10_HUMAN (Q9Y233)

# Metabolic_Enzyme_56_swissprot_Name:
Not Available

# Metabolic_Enzyme_56_Genecard_id:
PDE10A

# Metabolic_Enzyme_56_Geneatlas_id:
PDE10A

# Metabolic_Enzyme_56_hgnc_id:
HGNC:8772

# Metabolic_Enzyme_56_PDB_ID:
Not Available

# Metabolic_Enzyme_56_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_56_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_56_Subcellular_Location:
Note=Located mostly to soluble cellular fractions

# Metabolic_Enzyme_56_Gene_Sequence:
>2340 bp
ATGAGGATAGAAGAGAGGAAATCCCAACATTTAACAGGTTTGACAGATGAAAAAGTGAAG
GCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCA
GAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAGATGAATCAGCTCCT
AAGGAAGTCAGCAGGTACCAAGATACGAATATGCAGGGAGTTGTATATGAACTAAACAGC
TATATAGAACAACGGTTGGACACAGGAGGAGACAACCAGCTACTCCTCTATGAACTGAGC
AGCATCATTAAAATAGCCACAAAAGCCGATGGATTTGCACTGTATTTCCTTGGAGAGTGC
AATAATAGCCTGTGTATATTCACGCCACCTGGGATAAAGGAAGGAAAACCCCGCCTCATC
CCTGCTGGGCCCATCACTCAGGGCACCACCGTCTCTGCTTATGTGGCCAAGTCCAGGAAA
ACACTGCTAGTAGAAGACATCCTTGGAGATGAACGATTTCCAAGAGGTACTGGACTGGAA
TCAGGGACTCGTATCCAGTCTGTTCTTTGCTTACCAATTGTCACTGCAATTGGTGACTTG
ATTGGTATTCTCGAGCTGTATCGGCACTGGGGCAAAGAAGCCTTCTGTCTTAGTCACCAG
GAGGTTGCAACAGCAAATCTTGCCTGGGCTTCAGTAGCAATACATCAGGTGCAGGTATGC
AGAGGCCTTGCCAAACAGACAGAATTGAATGACTTCCTACTCGACGTATCAAAAACATAT
TTTGATAACATAGTTGCAATAGATTCTCTACTTGAACACATAATGATATATGCAAAAAAC
CTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATAT
TCAGACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAA
GAGATAAGATTTTCAATTGAGAAAGGAATTGCTGGCCAAGTAGCAAGAACAGGGGAAGTC
CTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACA
GGCTACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGT
GTGGTGCAGATGGTCAACAAAATCAGTGGCAGTGCCTTCTCTAAAACAGATGAAAACAAC
TTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGA
ATTCGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATT
TGTACTTCAGAAGAGTGGCAAGGTCTCATGCAATTCACCCTTCCCGTGCGTCTCTGCAAA
GAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTT
GTCTACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGT
TTTATTATGTCTGTGAAGAAGAACTATCGGCGGGTTCCTTATCACAACTGGAAGCATGCG
GTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGAC
CTTGAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTC
AGTAACAGCTACCTGCAGAAGTTCGACCACCCTCTGGCCGCTCTCTACTCCACTTCCACC
ATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTTCAGTTGGAAGGGCACAATATC
TTCTCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATC
ATTGCCACAGACCTTGCTTTATACTTTGGAAACAGGAAGCAGTTGGAAGAGATGTACCAG
ACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATG
ACTGCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAAT
GATATATATGCAGAATTCTGGGCTGAGGGTGATGAAATGAAGAAATTGGGAATACAGCCT
ATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTAC
AATGCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCT
CTTCTGAAAGCATGCAGGGATAATCTCAGTCAGTGGGAGAAGGTGATTCGAGGGGAGGAG
ACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGA


# Metabolic_Enzyme_56_GenBank_ID_Gene:
AB020593

# Metabolic_Enzyme_56_Chromosome_Location:
Not Available

# Metabolic_Enzyme_56_Locus:
Not Available

# Metabolic_Enzyme_56_SNPs:
Not Available

# Metabolic_Enzyme_56_General_References:
10373451; 10393245; 14574404

# Metabolic_Enzyme_56_References:
Not Available

# Metabolic_Enzyme_57_ID:
5877

# Metabolic_Enzyme_57_Name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

# Metabolic_Enzyme_57_Synonyms:
Cam-PDE 1C; hCam-3

# Metabolic_Enzyme_57_Gene_Name:
PDE1C

# Metabolic_Enzyme_57_Protein_Sequence:
>Calcium/calmodulindependent 3',5'cyclic nucleotide phosphodiesterase 1
CMESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVV
DLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLR
RSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEA
SGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQT
VHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLEN
HHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQP
EAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRK
STMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAK
RSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKA
RLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSG
EQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPL
RHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK

# Metabolic_Enzyme_57_Number_of_Residues:
709

# Metabolic_Enzyme_57_Molecular_Weight:
80761

# Metabolic_Enzyme_57_Theoretical_pI:
9.31

# Metabolic_Enzyme_57_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_57_General_Function:
Not Available

# Metabolic_Enzyme_57_Specific_Function:
Has a high affinity for both cAMP and cGMP

# Metabolic_Enzyme_57_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_57_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_57_Pfam_Domain_Function:
PF00233:PDEase_I;
PF08499:PDEase_I_N

# Metabolic_Enzyme_57_Signals:
None

# Metabolic_Enzyme_57_Transmembrane_Regions:
None

# Metabolic_Enzyme_57_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_57_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_57_GenBank_ID_Protein:
1151111

# Metabolic_Enzyme_57_SwissProt_ID:
PDE1C_HUMAN (Q14123)

# Metabolic_Enzyme_57_swissprot_Name:
Not Available

# Metabolic_Enzyme_57_Genecard_id:
PDE1C

# Metabolic_Enzyme_57_Geneatlas_id:
PDE1C

# Metabolic_Enzyme_57_hgnc_id:
HGNC:8776

# Metabolic_Enzyme_57_PDB_ID:
Not Available

# Metabolic_Enzyme_57_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_57_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_57_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_57_Gene_Sequence:
>1905 bp
ATGGAGTCGCCAACCAAGGAGATTGAAGAATTTGAGAGCAACTCTCTGAAATACCTGCAA
CCGGAACAGATCGAGAAAATCTGGCTTCGGCTCCGCGGGCTGAGGAAATATAAGAAAACG
TCCCAGAGATTACGGTCTTTGGTCAAACAATTAGAGAGAGGGGAAGCTTCAGTGGTAGAT
CTTAAGAAGAATTTGGAATATGCAGCCACAGTGCTTGAATCTGTGTATATTGATGAAACA
AGGAGACTCCTGGATACAGAGGATGAGCTCAGTGACATTCAGTCAGATGCTGTGCCTTCT
GAGGTCCGAGACTGGCTGGCCTCCACCTTCACGCGGCAGATGGGGATGATGCTCAGGAGG
AGCGACGAGAAGCCCCGGTTCAAGAGCATCGTTCACGCAGTGCAGGCTGGGATATTTGTG
GAGAGAATGTATAGACGGACATCAAACATGGTTGGACTGAGCTATCCACCAGCTGTTATT
GAGGCATTAAAGGATGTGGACAAGTGGTCCTTTGACGTCTTTTCCCTCAATGAGGCCAGT
GGGGATCATGCACTGAAATTTATTTTCTATGAACTACTCACACGTTATGATCTGATCAGC
CGTTTCAAGATCCCCATTTCTGCACTTGTCTCATTTGTGGAGGCCCTGGAAGTGGGATAC
AGCAAGCACAAAAATCCTTACCATAACTTAATGCACGCTGCCGATGTTACACAGACAGTG
CATTACCTCCTCTATAAGACAGGAGTGGCGAACTGGCTGACGGAGCTGGAGATCTTTGCT
ATAATCTTCTCAGCTGCCATCCATGACTACGAGCATACCGGAACCACCAACAATTTCCAC
ATTCAGACTCGGTCTGATCCAGCTATTCTGTATAATGACAGATCTGTACTGGAGAATCAC
CATTTAAGTGCAGCTTATCGCCTTCTGCAAGATGACGAGGAAATGAATATTTTGATTAAC
CTCTCAAAGGATGACTGGAGGGAGTTTCGAACCTTGGTAATTGAAATGGTGATGGCCACA
GATATGTCTTGTCACTTCCAACAAATCAAAGCAATGAAGACTGCTCTGCAGCAGCCAGAA
GCCATTGAAAAGCCAAAAGCCTTATCCCTTATGCTGCATACAGCAGATATTAGCCATCCA
GCAAAAGCATGGGACCTCCATCATCGCTGGACAATGTCACTCCTGGAGGAGTTCTTCAGA
CAGGGTGACAGAGAAGCAGAGCTGGGGCTGCCTTTTTCTCCTCTGTGTGACCGAAAGTCC
ACTATGGTTGCTCAGTCACAAGTAGGTTTCATTGATTTCATCGTGGAACCCACCTTCACT
GTGCTTACGGACATGACCGAGAAGATTGTGAGTCCATTAATCGATGAAACCTCTCAAACT
GGTGGGACAGGACAGAGGCGTTCGAGTTTGAATAGCATCAGCTCGTCAGATGCCAAGCGA
TCAGGTGTCAAGACCTCTGGTTCAGAGGGAAGTGCCCCGATCAACAATTCTGTCATCTCC
GTTGACTATAAGAGCTTTAAAGCTACTTGGACGGAAGTGGTGCACATCAATCGGGAGAGA
TGGAGGGCCAAGGTACCCAAAGAGGAGAAGGCCAAGAAGGAAGCAGAGGAAAAGGCTCGC
CTGGCCGCAGAGGAGCAGCAAAAGGAAATGGAAGCCAAAAGCCAGGCTGAAGAAGGCGCA
TCTGGCAAAGCTGAGAAAAAGACGTCTGGAGAAACTAAGAATCAAGTCAATGGAACACGG
GCAAACAAAAGTGACAACCCTCGTGGGAAAAATTCCAAAGCCGAGAAGTCATCAGGAGAA
CAGCAACAGAATGGTGACTTCAAAGATGGTAAAAATAAGACAGACAAGAAGGATCACTCT
AACATCGGAAATGATTCAAAGAAAACAGATGATTCACAAGAGTAA

# Metabolic_Enzyme_57_GenBank_ID_Gene:
U40371

# Metabolic_Enzyme_57_Chromosome_Location:
Not Available

# Metabolic_Enzyme_57_Locus:
Not Available

# Metabolic_Enzyme_57_SNPs:
Not Available

# Metabolic_Enzyme_57_General_References:
8557689

# Metabolic_Enzyme_57_References:
Not Available

# Metabolic_Enzyme_58_ID:
5878

# Metabolic_Enzyme_58_Name:
Tyrosyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_58_Synonyms:
Tyrosyl--tRNA ligase; TyrRS

# Metabolic_Enzyme_58_Gene_Name:
YARS

# Metabolic_Enzyme_58_Protein_Sequence:
>TyrosyltRNA synthetase, cytoplasmic
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

# Metabolic_Enzyme_58_Number_of_Residues:
528

# Metabolic_Enzyme_58_Molecular_Weight:
59144

# Metabolic_Enzyme_58_Theoretical_pI:
7.05

# Metabolic_Enzyme_58_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  nucleic acid binding
Function:  RNA binding
Function:  tRNA binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_58_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_58_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_58_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_58_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_58_Pfam_Domain_Function:
PF00579:tRNA-synt_1b;
PF01588:tRNA_bind

# Metabolic_Enzyme_58_Signals:
None

# Metabolic_Enzyme_58_Transmembrane_Regions:
None

# Metabolic_Enzyme_58_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_58_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_58_GenBank_ID_Protein:
1184699

# Metabolic_Enzyme_58_SwissProt_ID:
SYYC_HUMAN (P54577)

# Metabolic_Enzyme_58_swissprot_Name:
Not Available

# Metabolic_Enzyme_58_Genecard_id:
YARS

# Metabolic_Enzyme_58_Geneatlas_id:
YARS

# Metabolic_Enzyme_58_hgnc_id:
HGNC:12840

# Metabolic_Enzyme_58_PDB_ID:
Not Available

# Metabolic_Enzyme_58_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_58_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_58_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_58_Gene_Sequence:
>1167 bp
ATGGGGGACGCTCCCAGCCCTGAAGAGAAACTGCACCTTATCACCCGGAACCTGCAGGAG
GTTCTGGGGGAAGAGAAGCTGAAGGAGATACTGAAGGAGCGGGAACTTAAAATTTACTGG
GGAACGGCAACCACGGGCAAACCACATGTGGCTTACTTTGTGCCCATGTCAAAGATTGCA
GACTTCTTAAAGGCAGGGTGTGAGGTAACAATTCTGTTTGCGGACCTCCACGCATACCTG
GATAACATGAAAGCCCCATGGGAACTTCTAGAACTCCGAGTCAGTTACTATGAGAATGTG
ATCAAAGCAATGCTGGAGAGCATTGGTGTGCCCTTGGAGAAGCTCAAGTTCATCAAAGGC
ACTGATTACCAGCTCAGCAAAGAGTACACACTAGATGTGTACAGACTCTCCTCCGTGGTC
ACACAGCACGATTCCAAGAAGGCTGGAGCTGAGGTGGTAAAGCAGGTGGAGCACCCTTTG
CTGAGTGGCCTCTTATACCCCGGACTGCAGGCTTTGGATGAAGAGTATTTAAAAGTAGAT
GCCCAATTTGGAGGCATTGATCAGAGAAAGATTTTCACCTTTGCAGAGAAGTACCTCCCT
GCACTTGGCTATTCAAAACGGGTCCATCTGATGAATCCTATGGTTCCAGGATTAACAGGC
AGCAAAATGAGCTCTTCAGAAGAGGAGTCCAAGATTGATCTCCTTGATCGGAAGGAGGAT
GTGAAGAAAAAACTGAAGAAGGCCTTCTGTGAGCCAGGAAATGTGGAGAACAATGGGGTT
CTGTCCTTCATCAAGCATGTCCTTTTTCCCCTTAAGTCCGAGTTTGTGATCCTACGAGAT
GAGAAATGGGGTGGAAACAAAACCTACACAGCTTACGTGGACCTGGAAAAGGACTTTGCT
GCTGAGGTTGTACATCCTGGAGACCTGAAGAATTCTGTTGAAGTCGCACTGAACAAGTTG
CTGGATCCAATCCGGGAAAAGTTTAATACCCCTGCCCTGAAAAAACTGGCCAGCGCTGCC
TACCCAGATCCCTCAAAGCAGAAGCCAATGGCCAAAGGCCTGCCAAGAATTCAGAACCAG
AGGAGGTCATCCCATCCCGGCTGGATATCCGTGTGGGGAAAATCATCACTGTGGAGAAGC
ACCCAGATGCAGACAGCCTGTATGTAG

# Metabolic_Enzyme_58_GenBank_ID_Gene:
U40714

# Metabolic_Enzyme_58_Chromosome_Location:
Not Available

# Metabolic_Enzyme_58_Locus:
Not Available

# Metabolic_Enzyme_58_SNPs:
Not Available

# Metabolic_Enzyme_58_General_References:
8552597; 9162081; 12665801

# Metabolic_Enzyme_58_References:
Not Available

# Metabolic_Enzyme_59_ID:
5879

# Metabolic_Enzyme_59_Name:
DNA ligase 3

# Metabolic_Enzyme_59_Synonyms:
DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3

# Metabolic_Enzyme_59_Gene_Name:
LIG3

# Metabolic_Enzyme_59_Protein_Sequence:
>DNA ligase 3
MAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKL
ERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTTTGQ
VTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKRSLSSSKCDPRHKDCLLREFR
KLCAMVADNPSYNTKTQIIQDFLRKGSAGDGFHGDVYLTVKLLLPGVIKTVYNLNDKQIV
KLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDEFLLRLSKL
TKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNL
QDVVERVLHNAQEVEKEPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEI
KYDGERVQVHKNGDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNK
TGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNR
IMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMA
DTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDM
VKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRC
TRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSR
KAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKVGEKRKAADET
LCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPA
AQQVSPEWIWACIRKRRLVAPC

# Metabolic_Enzyme_59_Number_of_Residues:
922

# Metabolic_Enzyme_59_Molecular_Weight:
102692

# Metabolic_Enzyme_59_Theoretical_pI:
9.17

# Metabolic_Enzyme_59_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus
Component:  cell
Component:  intracellular

# Metabolic_Enzyme_59_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_59_Specific_Function:
Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

# Metabolic_Enzyme_59_Pathway:
Not Available

# Metabolic_Enzyme_59_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_59_Pfam_Domain_Function:
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N;
PF00645:zf-PARP

# Metabolic_Enzyme_59_Signals:
None

# Metabolic_Enzyme_59_Transmembrane_Regions:
None

# Metabolic_Enzyme_59_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_59_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_59_GenBank_ID_Protein:
860963

# Metabolic_Enzyme_59_SwissProt_ID:
DNL3_HUMAN (P49916)

# Metabolic_Enzyme_59_swissprot_Name:
Not Available

# Metabolic_Enzyme_59_Genecard_id:
LIG3

# Metabolic_Enzyme_59_Geneatlas_id:
LIG3

# Metabolic_Enzyme_59_hgnc_id:
HGNC:6600

# Metabolic_Enzyme_59_PDB_ID:
Not Available

# Metabolic_Enzyme_59_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_59_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_59_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_59_Gene_Sequence:
>2769 bp
ATGGCTGAGCAACGGTTCTGTGTGGACTATGCCAAGCGTGGCACAGCTGGCTGCAAAAAA
TGCAAGGAAAAGATTGTGAAGGGCGTATGCCGAATTGGCAAAGTGGTGCCCAATCCCTTC
TCAGAGTCTGGGGGTGATATGAAAGAGTGGTACCACATTAAATGCATGTTTGAGAAACTA
GAGCGGGCCCGGGCCACCACAAAAAAAATCGAGGACCTCACAGAGCTGGAAGGCTGGGAA
GAGCTGGAAGATAATGAGAAGGAACAGATAACCCAGCACATTGCAGATCTGTCTTCTAAG
GCAGCAGGTACACCAAAGAAGAAAGCTGTTGTCCAGGCTAAGTTGACAACCACTGGCCAG
GTGACTTCTCCAGTGAAAGGCGCCTCATTTGTCACCAGTACCAATCCCCGGAAATTTTCT
GGCTTTTCAGCCAAGCCCAACAACTCTGGGGAAGCCCCCTCGAGCCCCACCCCTAAGAGA
AGTCTGTCTTCAAGCAAATGTGACCCCAGGCATAAGGACTGTCTGCTACGGGAGTTTCGA
AAGTTATGCGCCATGGTGGCCGATAATCCTAGCTACAACACGAAGACCCAGATCATCCAG
GACTTCCTTCGGAAAGGCTCAGCAGGAGATGGTTTCCACGGTGATGTGTACCTAACAGTG
AAGCTGCTGCTGCCAGGAGTCATTAAGACTGTTTACAACTTGAACGATAAGCAGATTGTG
AAGCTTTTCAGTCGCATTTTTAACTGCAACCCAGATGATATGGCACGGGACCTAGAGCAG
GGTGACGTGTCAGAGACAATCAGAGTCTTCTTTGAGCAGAGCAAGTCTTTCCCCCCAGCT
GCCAAGAGCCTCCTTACCATCCAGGAAGTGGATGAGTTCCTTCTGCGGCTGTCCAAGCTC
ACCAAGGAGGATGAGCAGCAACAGGCCCTACAGGACATTGCCTCCAGGTGTACAGCCAAT
GACCTTAAATGCATCATCAGGTTGATCAAACATGATCTGAAGATGAACTCAGGTGCAAAA
CATGTGTTAGACGCCCTTGACCCCAATGCCTATGAAGCCTTCAAAGCCTCGCGCAACCTG
CAGGATGTGGTGGAGCGGGTCCTTCACAACGCGCAGGAGGTGGAGAAGGAGCCGGGCCAG
AGACGAGCTCTGAGCGTCCAGGCCTCGCTGATGACACCTGTGCAGCCCATGTTGGCGGAG
GCCTGCAAGTCCGTTGAGTATGCAATGAAGAAATGTCCCAATGGCATGTTCTCTGAGATC
AAGTACGATGGAGAGCGAGTCCAGGTGCATAAGAATGGAGACCACTTCAGCTACTTCAGC
CGCAGTCTCAAGCCCGTCCTTCCTCACAAGGTGGCCCACTTTAAGGACTACATTCCCCAG
GCTTTTCCTGGGGGCCACAGCATGATCTTGGATTCTGAAGTGCTTCTGATTGACAACAAG
ACAGGCAAACCACTGCCCTTTGGGACTCTGGGAGTACACAAGAAAGCAGCCTTCCAGGAT
GCTAATGTCTGCCTGTTTGTTTTTGATTGTATCTACTTTAATGATGTCAGCTTGATGGAC
AGACCTCTGTGTGAGCGGCGGAAGTTTCTTCATGACAACATGGTTGAAATTCCAAACCGG
ATCATGTTCTCAGAAATGAAGCGAGTCACAAAAGCTTTGGACTTGGCTGACATGATAACC
CGGGTGATCCAGGAGGGATTGGAGGGGCTGGTGCTGAAGGATGTGAAGGGTACATATGAG
CCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACTATTTGAACGAGGGGGCCATGGCC
GACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATG
ATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACC
AAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCCGCCTGCAGAATGAACTAGACATG
GTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTAC
TATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCT
GAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGATCTCCATCCGATTCCCTCGCTGC
ACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAA
CTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGC
TCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTCCCTCAGGGTCTGCTGTGTCCCGC
AAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCC
AACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAG
CTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGAAGCGGAAAGCTGCTGATGAGACG
CTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCC
TCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTA
CAGGAATTTGATATGACTTCAGCCACGCACGTGCTGGGTAGCAGGGACAAGAACCCTGCG
GCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCT
CCCTGCTAG

# Metabolic_Enzyme_59_GenBank_ID_Gene:
X84740

# Metabolic_Enzyme_59_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_59_Locus:
17q11.2-q12

# Metabolic_Enzyme_59_SNPs:
rs4986973; rs3136025; rs3744356; rs1076992; rs3136022; rs4986976; rs3135988; rs4796030; rs1052536; rs9898719; rs3135960; rs16970536; rs12945428; rs3135958; rs3135998; rs2066505; rs3135989; rs3135992; rs2074522; rs3135980; rs11868699; rs3136011; rs2074517; rs3135972; rs2074521; rs3136000; rs3135977; rs3135986; rs3136026; rs3136001; rs3136024; rs3136031; rs2074516; rs3135993; rs3136027; rs3136005; rs3135968; rs3135983; rs3135966; rs2074518; rs3135984; rs3135974; rs3135967; rs3136002; rs3135962; rs3136018; rs3135965; rs3135985; rs16970512; rs3135981; rs3136003; rs3136034; rs3135964; rs3136023; rs3135996; rs3136007; rs3136014; rs3136035; rs3135963; rs3135982; rs3136032; rs3135990; rs3136020; rs3136009; rs3135970; rs3135991; rs3136028; rs4986975; rs3136006; rs1003918; rs9895135; rs1802880; rs4986974; rs36021499; rs35501315; rs35956074; rs2066504; rs3084117; rs9910720; rs5820097; rs3135959; rs34885824; rs35202391; rs3136033; rs3135973; rs34608528; rs3135999; rs3136029; rs34029311; rs3135995; rs3136030; rs2074514; rs3136004; rs3136013; rs3785753; rs3136008; rs34258855; rs35262612; rs3135969; rs12150248; rs3136017; rs2879347; rs3136010; rs12941420; rs35195908; rs16970494; rs35406467; rs3135997; rs3135976; rs3135971; rs3136016; rs3135979; rs2014060; rs3135975; rs34568492; rs3135987; rs36027201; rs3136015; rs3136021; rs3135994; rs35610965; rs3136019; rs2074515; rs3136012; rs3135978; rs12952527; rs35071763; rs12325783; rs12947086; rs12948362; rs16970540; rs1859248; rs2074519; rs2074520; rs35426973; rs35744965; rs35903939; rs3744357; rs3744358; rs3744359; rs8077161; rs8079452; rs9167; rs978202; rs9915258

# Metabolic_Enzyme_59_General_References:
7760816; 7565692

# Metabolic_Enzyme_59_References:
Not Available

# Metabolic_Enzyme_60_ID:
5880

# Metabolic_Enzyme_60_Name:
Aspartyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_60_Synonyms:
Aspartate--tRNA ligase; AspRS; Cell proliferation-inducing gene 40 protein

# Metabolic_Enzyme_60_Gene_Name:
DARS

# Metabolic_Enzyme_60_Protein_Sequence:
>AspartyltRNA synthetase, cytoplasmic
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV
EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLTP

# Metabolic_Enzyme_60_Number_of_Residues:
501

# Metabolic_Enzyme_60_Molecular_Weight:
57137

# Metabolic_Enzyme_60_Theoretical_pI:
6.52

# Metabolic_Enzyme_60_GO_Classification:
>>>
Function:  nucleic acid binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  aspartate-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  aspartyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_60_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_60_Specific_Function:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

# Metabolic_Enzyme_60_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_60_Reaction:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

# Metabolic_Enzyme_60_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_60_Signals:
None

# Metabolic_Enzyme_60_Transmembrane_Regions:
None

# Metabolic_Enzyme_60_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_60_EC_Link:
EC 6.1.1.12

# Metabolic_Enzyme_60_GenBank_ID_Protein:
179102

# Metabolic_Enzyme_60_SwissProt_ID:
SYDC_HUMAN (P14868)

# Metabolic_Enzyme_60_swissprot_Name:
Not Available

# Metabolic_Enzyme_60_Genecard_id:
DARS

# Metabolic_Enzyme_60_Geneatlas_id:
DARS

# Metabolic_Enzyme_60_hgnc_id:
HGNC:2678

# Metabolic_Enzyme_60_PDB_ID:
Not Available

# Metabolic_Enzyme_60_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_60_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_60_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_60_Gene_Sequence:
>1503 bp
ATGCCCAGCGCCACGCAGCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCGGCG
GAAGATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAACCA
GATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTTTGG
GTACGTGCAAGAGTTCATACAAGCAGAGCTAAAGGGAAACAGTGCTTCTTAGTCCTACGT
CAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAGATG
GTTAAATTTGCTGCCAACATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTGAGA
AAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACATGTTCAGAAG
ATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTTCGG
CCTGAGCAAGAAGGAGAAGAGGAAGGAAGAGCTACTGTTAACCAGGATACAAGATTAGAC
AACAGAGTCATTGATCTTAGGACATCAACTAGTCAGGCAGTCTTCCGTCTCCAGTCTGGC
ATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACTCCT
AAAATTATTTCAGCTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTTAAA
AATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATTTGTGCTGAT
TTTGAGAAGGTTTTCTCTATTGGACCAGTATTCAGAGCGGAAGACTCTAATACCCATAGA
CATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCACGAA
GTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAAGAAAGGTTT
CAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTGGAG
CCAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTCGAA
ATGGGAGATGAAGACGATCTGAGCACACCAAATGAAAAGCTGTTGGGTCATTTGGTAAAG
GAAAAGTATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCTTTC
TATACCATGCCTGACCCAAGAAATCCCAAACAGTCCAAGTCTTACGATATGTTCATGAGA
GGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTAACAGAGAGA
GCTTTACATCATGGAAATGATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGCTTT
GGAGCCCCTCCTCATGCTGGTGGAGGCATTGGATTGGAACGAGTTACTATGCTGTTTCTG
GGATTGCATAATGTTCGTCAGACCTCCATGTTCCCTCGTGATCCCAAACGACTCACTCCT
TAA

# Metabolic_Enzyme_60_GenBank_ID_Gene:
J05032

# Metabolic_Enzyme_60_Chromosome_Location:
Not Available

# Metabolic_Enzyme_60_Locus:
Not Available

# Metabolic_Enzyme_60_SNPs:
Not Available

# Metabolic_Enzyme_60_General_References:
2674137

# Metabolic_Enzyme_60_References:
Not Available

# Metabolic_Enzyme_61_ID:
5881

# Metabolic_Enzyme_61_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B

# Metabolic_Enzyme_61_Synonyms:
DPDE4; PDE32

# Metabolic_Enzyme_61_Gene_Name:
PDE4B

# Metabolic_Enzyme_61_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
BMKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQ
SERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLV
LHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSV
RNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTY
RSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKK
KKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYS
HNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTH
VLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
LAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVT
SSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGME
ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQS
PSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSL
GETDIDIATEDKSPVDT

# Metabolic_Enzyme_61_Number_of_Residues:
736

# Metabolic_Enzyme_61_Molecular_Weight:
83344

# Metabolic_Enzyme_61_Theoretical_pI:
4.89

# Metabolic_Enzyme_61_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_61_General_Function:
Not Available

# Metabolic_Enzyme_61_Specific_Function:
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents

# Metabolic_Enzyme_61_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_61_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_61_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_61_Signals:
None

# Metabolic_Enzyme_61_Transmembrane_Regions:
None

# Metabolic_Enzyme_61_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_61_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_61_GenBank_ID_Protein:
347122

# Metabolic_Enzyme_61_SwissProt_ID:
PDE4B_HUMAN (Q07343)

# Metabolic_Enzyme_61_swissprot_Name:
Not Available

# Metabolic_Enzyme_61_Genecard_id:
PDE4B

# Metabolic_Enzyme_61_Geneatlas_id:
PDE4B

# Metabolic_Enzyme_61_hgnc_id:
HGNC:8781

# Metabolic_Enzyme_61_PDB_ID:
Not Available

# Metabolic_Enzyme_61_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_61_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_61_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_61_Gene_Sequence:
>2211 bp
ATGAAGAAAAGCAGGAGTGTGATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTT
GAATGTAGCTTGAGTAAATCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGG
AGAGGGAGAAGGTGTTGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGT
GAAAGGGCAAGGACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACA
ACGCTTCCAAGCATTGCTATTACAACTGTAAGCCAGGAGTGCTTTGATGTGGAAAATGGC
CCTTCCCCAGGTCGGAGTCCACTGGATCCCCAGGCCAGCTCTTCCGCTGGGCTGGTACTT
CACGCCACCTTTCCTGGGCACAGCCAGCGCAGAGAGTCATTTCTCTACAGATCAGACAGC
GACTATGACTTGTCACCAAAGGCGATGTCGAGAAACTCTTCTCTTCCAAGCGAGCAACAC
GGCGATGACTTGATTGTAACTCCTTTTGCCCAGGTCCTTGCCAGCTTGCGAAGTGTGAGA
AACAACTTCACTATACTGACAAACCTTCATGGTACATCTAACAAGAGGTCCCCAGCTGCT
AGTCAGCCTCCTGTCTCCAGAGTCAACCCACAAGAAGAATCTTATCAAAAATTAGCAATG
GAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAGCTAGAGACCATACAGACCTACCGG
TCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGAATGCTGAACCGGGAGCTGACACAC
CTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCTGAATACATTTCAAATACTTTCTTA
GACAAGCAGAATGATGTGGAGATCCCATCTCCTACCCAGAAAGACAGGGAGAAAAAGAAA
AAGCAGCAGCTCATGACCCAGATAAGTGGAGTGAAGAAATTAATGCATAGTTCAAGCCTA
AACAATACAAGCATCTCACGCTTTGGAGTCAACACTGAAAATGAAGATCACCTGGCCAAG
GAGCTGGAAGACCTGAACAAATGGGGTCTTAACATCTTTAATGTGGCTGGATATTCTCAC
AATAGACCCCTAACATGCATCATGTATGCTATATTCCAGGAAAGAGACCTCCTAAAGACA
TTCAGAATCTCATCTGACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCAT
TCTGACGTGGCATATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTT
CTCCTTTCTACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATT
TTTGCAGCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAAC
ACAAATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTT
GCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACCAAG
AAGCAGCGTCAGACACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGATATGTCT
AAACATATGAGCCTGCTGGCAGACCTGAAGACAATGGTAGAAACGAAGAAAGTTACAAGT
TCAGGCGTTCTTCTCCTAGACAACTATACCGATCGCATTCAGGTCCTTCGCAACATGGTA
CACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTGGAATTGTATCGGCAATGGACAGAC
CGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAAGAGCGGGAGAGGGGAATGGAAATT
AGCCCAATGTGTGATAAACACACAGCTTCTGTGGAAAAATCCCAGGTTGGTTTCATCGAC
TACATTGTCCATCCATTGTGGGAGACATGGGCAGATTTGGTACAGCCTGATGCTCAGGAC
ATTCTCGATACCTTAGAAGATAACAGGAACTGGTATCAGAGCATGATACCTCAAAGTCCC
TCACCACCACTGGACGAGCAGAACAGGGACTGCCAGGGTCTGATGGAGAAGTTTCAGTTT
GAACTGACTCTCGATGAGGAAGATTCTGAAGGACCTGAGAAGGAGGGAGAGGGACACAGC
TATTTCAGCAGCACAAAGACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCCCTGGGA
GAGACTGACATAGACATTGCAACAGAAGACAAGTCCCCCGTGGATACATAA

# Metabolic_Enzyme_61_GenBank_ID_Gene:
L20966

# Metabolic_Enzyme_61_Chromosome_Location:
Not Available

# Metabolic_Enzyme_61_Locus:
Not Available

# Metabolic_Enzyme_61_SNPs:
Not Available

# Metabolic_Enzyme_61_General_References:
8413254; 9371714; 8384210

# Metabolic_Enzyme_61_References:
Not Available

# Metabolic_Enzyme_62_ID:
5578

# Metabolic_Enzyme_62_Name:
3'(2'),5'-bisphosphate nucleotidase 1

# Metabolic_Enzyme_62_Synonyms:
Bisphosphate 3'- nucleotidase 1; PAP-inositol-1,4-phosphatase; PIP

# Metabolic_Enzyme_62_Gene_Name:
BPNT1

# Metabolic_Enzyme_62_Protein_Sequence:
>3'2',5'bisphosphate nucleotidase 1
MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICS
SLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLD
GTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGF
QLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFAS
PGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPE
SIKNALVP

# Metabolic_Enzyme_62_Number_of_Residues:
308

# Metabolic_Enzyme_62_Molecular_Weight:
33393

# Metabolic_Enzyme_62_Theoretical_pI:
5.41

# Metabolic_Enzyme_62_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  inositol or phosphatidylinositol phosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_62_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_62_Specific_Function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6

# Metabolic_Enzyme_62_Pathway:
map00920  Sulfur metabolism

# Metabolic_Enzyme_62_Reaction:
adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate

# Metabolic_Enzyme_62_Pfam_Domain_Function:
PF00459:Inositol_P

# Metabolic_Enzyme_62_Signals:
1-19

# Metabolic_Enzyme_62_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_62_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_62_EC_Link:
EC 3.1.3.7

# Metabolic_Enzyme_62_GenBank_ID_Protein:
4325316

# Metabolic_Enzyme_62_SwissProt_ID:
BPNT1_HUMAN (O95861)

# Metabolic_Enzyme_62_swissprot_Name:
Not Available

# Metabolic_Enzyme_62_Genecard_id:
BPNT1

# Metabolic_Enzyme_62_Geneatlas_id:
BPNT1

# Metabolic_Enzyme_62_hgnc_id:
HGNC:1096

# Metabolic_Enzyme_62_PDB_ID:
1JP4

# Metabolic_Enzyme_62_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_62_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_62_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_62_Gene_Sequence:
>927 bp
ATGGCTTCCAGTAACACTGTGTTGATGCGGTTGGTAGCCTCCGCATATTCTATTGCTCAA
AAGGCAGGAATGATAGTCAGACGTGTTATTGCTGAAGGAGACCTGGGTATTGTGGAGAAG
ACCTGTGCAACAGACCTGCAGACCAAAGCTGACCGATTGGCACAGATGAGCATATGTTCT
TCATTGGCCCGGAAATTCCCCAAACTCACAATTATAGGGGAAGAGGATCTGCCTTCTGAG
GAAGTGGATCAAGAGCTGATTGAAGACAGTCAGTGGGAAGAAATACTGAAGCAACCATGC
CCATCGCAGTACAGTGCTATTAAAGAAGAAGATCTCGTGGTCTGGGTTGATCCTCTGGAT
GGAACCAAGGAATATACCGAAGGTCTTCTTGACAATGTAACAGTTCTTATTGGAATTGCT
TATGAAGGAAAAGCCATAGCAGGAGTTATTAACCAGCCATATTACAACTATGAGGCAGGA
CCAGATGCTGTGTTGGGGAGGACAATCTGGGGAGTTTTAGGTTTAGGCGCCTTTGGGTTT
CAGCTGAAAGAAGTCCCTGCTGGGAAACACATTATCACAACTACTCGATCCCATAGCAAC
AAGTTGGTTACTGACTGTGTTGCTGCTATGAACCCCGATGCTGTGCTGCGAGTAGGAGGA
GCAGGAAATAAGATTATTCAGCTGATTGAAGGCAAAGCCTCTGCTTATGTATTTGCAAGT
CCTGGTTGTAAGAAGTGGGATACTTGTGCTCCAGAAGTTATTTTACATGCTGTGGGAGGC
AAGTTAACCGATATCCATGGGAATGTTCTTCAGTACCACAAGGATGTGAAGCATATGAAC
TCTGCAGGAGTCCTGGCCACACTGAGGAATTATGACTACTATGCAAGCCGAGTTCCAGAA
TCTATTAAAAATGCACTTGTTCCTTAA

# Metabolic_Enzyme_62_GenBank_ID_Gene:
AF125042

# Metabolic_Enzyme_62_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_62_Locus:
1q41

# Metabolic_Enzyme_62_SNPs:
rs904327; rs2647471; rs2647472; rs2789785; rs12133210; rs2647465; rs2889876; rs12568334; rs6661761; rs6704420; rs12136801; rs1146773; rs904328; rs2053250; rs1146774; rs17563262; rs12116864; rs1611863; rs6673800; rs12145672; rs12135677; rs34406824; rs7524161; rs11586452; rs2577152; rs11803960; rs2647466; rs7538757; rs12734813; rs12407434; rs35038735; rs12404973; rs12086370; rs34887640; rs3201549; rs12138628; rs12408053; rs12410587; rs35675420; rs1137752; rs34639450; rs12046760; rs1137753; rs2577132; rs3055553; rs9431224; rs12081255; rs2577133; rs10702348; rs3201546; rs2577131; rs12037811; rs3055555; rs34628672; rs2789786; rs17856551; rs1051435; rs35221551; rs11118493; rs35619743; rs12033581; rs12038562; rs6667047; rs12726102; rs35685939; rs12757995; rs7516345; rs7530481; rs11292010; rs34257886; rs41274792; rs9430910; rs4268361; rs17856552; rs35431487; rs9969996; rs2486327; rs41274790; rs9430911; rs34136285; rs34674672; rs34025792; rs2247212; rs41274794; rs35600968; rs2577135; rs35546692; rs11405609; rs9430912; rs1612813; rs34118944; rs7515463; rs2789787; rs7531190; rs35894683; rs34255218; rs10648388; rs28445890; rs9430913; rs34672561; rs12066555; rs12026465; rs7531770; rs35677563; rs34649864; rs34638408; rs12127171; rs10157645; rs17007107; rs34116851; rs34980841; rs7516830; rs7549576

# Metabolic_Enzyme_62_General_References:
10224133

# Metabolic_Enzyme_62_References:
Not Available

# Metabolic_Enzyme_63_ID:
5232

# Metabolic_Enzyme_63_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_63_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_63_Gene_Name:
NT5C1B

# Metabolic_Enzyme_63_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_63_Number_of_Residues:
610

# Metabolic_Enzyme_63_Molecular_Weight:
68804

# Metabolic_Enzyme_63_Theoretical_pI:
9.03

# Metabolic_Enzyme_63_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_63_General_Function:
Not Available

# Metabolic_Enzyme_63_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_63_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_63_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_63_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_63_Signals:
None

# Metabolic_Enzyme_63_Transmembrane_Regions:
None

# Metabolic_Enzyme_63_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_63_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_63_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_63_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_63_swissprot_Name:
Not Available

# Metabolic_Enzyme_63_Genecard_id:
NT5C1B

# Metabolic_Enzyme_63_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_63_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_63_PDB_ID:
Not Available

# Metabolic_Enzyme_63_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_63_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_63_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_63_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_63_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_63_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_63_Locus:
2p24.2

# Metabolic_Enzyme_63_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_63_General_References:
11690631

# Metabolic_Enzyme_63_References:
Not Available

# Metabolic_Enzyme_64_ID:
5882

# Metabolic_Enzyme_64_Name:
Ubiquitin-conjugating enzyme E2 D3

# Metabolic_Enzyme_64_Synonyms:
Ubiquitin-protein ligase D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2-17 kDa 3; E2(17KB 3

# Metabolic_Enzyme_64_Gene_Name:
UBE2D3

# Metabolic_Enzyme_64_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 D3
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDRDKYNRISREWTQKYAM

# Metabolic_Enzyme_64_Number_of_Residues:
147

# Metabolic_Enzyme_64_Molecular_Weight:
16687

# Metabolic_Enzyme_64_Theoretical_pI:
7.95

# Metabolic_Enzyme_64_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_64_General_Function:
Not Available

# Metabolic_Enzyme_64_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53

# Metabolic_Enzyme_64_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_64_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_64_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_64_Signals:
None

# Metabolic_Enzyme_64_Transmembrane_Regions:
None

# Metabolic_Enzyme_64_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_64_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_64_GenBank_ID_Protein:
1145691

# Metabolic_Enzyme_64_SwissProt_ID:
UB2D3_HUMAN (P61077)

# Metabolic_Enzyme_64_swissprot_Name:
Not Available

# Metabolic_Enzyme_64_Genecard_id:
UBE2D3

# Metabolic_Enzyme_64_Geneatlas_id:
UBE2D3

# Metabolic_Enzyme_64_hgnc_id:
HGNC:12476

# Metabolic_Enzyme_64_PDB_ID:
1X23

# Metabolic_Enzyme_64_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_64_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_64_Subcellular_Location:
Not Available

# Metabolic_Enzyme_64_Gene_Sequence:
>444 bp
ATGGCGCTGAAACGGATTAATAAGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAA
TGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCT
AATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCT
AAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTG
CCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAA
TGGACTCAGAAGTATGCCATGTGA

# Metabolic_Enzyme_64_GenBank_ID_Gene:
U39318

# Metabolic_Enzyme_64_Chromosome_Location:
Not Available

# Metabolic_Enzyme_64_Locus:
Not Available

# Metabolic_Enzyme_64_SNPs:
Not Available

# Metabolic_Enzyme_64_General_References:
8530467

# Metabolic_Enzyme_64_References:
Not Available

# Metabolic_Enzyme_65_ID:
5883

# Metabolic_Enzyme_65_Name:
Asparaginyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_65_Synonyms:
Asparagine-- tRNA ligase; AsnRS

# Metabolic_Enzyme_65_Gene_Name:
NARS

# Metabolic_Enzyme_65_Protein_Sequence:
>AsparaginyltRNA synthetase, cytoplasmic
MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISK
SQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGAL
EGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVA
VYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGE
NMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSS
QLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCD
VVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIP
EAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIF
DSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYP
RFVQRCTP

# Metabolic_Enzyme_65_Number_of_Residues:
548

# Metabolic_Enzyme_65_Molecular_Weight:
62944

# Metabolic_Enzyme_65_Theoretical_pI:
6.17

# Metabolic_Enzyme_65_GO_Classification:
>>>
Function:  aspartate-tRNA ligase activity
Function:  nucleic acid binding
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  asparagine-tRNA ligase activity
 ||
>>>
Process:  aspartyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  asparaginyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_65_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_65_Specific_Function:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_65_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_65_Reaction:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

# Metabolic_Enzyme_65_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_65_Signals:
None

# Metabolic_Enzyme_65_Transmembrane_Regions:
None

# Metabolic_Enzyme_65_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_65_EC_Link:
EC 6.1.1.22

# Metabolic_Enzyme_65_GenBank_ID_Protein:
2764505

# Metabolic_Enzyme_65_SwissProt_ID:
SYNC_HUMAN (O43776)

# Metabolic_Enzyme_65_swissprot_Name:
Not Available

# Metabolic_Enzyme_65_Genecard_id:
NARS

# Metabolic_Enzyme_65_Geneatlas_id:
NARS

# Metabolic_Enzyme_65_hgnc_id:
HGNC:7643

# Metabolic_Enzyme_65_PDB_ID:
Not Available

# Metabolic_Enzyme_65_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_65_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_65_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_65_Gene_Sequence:
>1647 bp
ATGGTGCTAGCAGAGCTGTACGTCTCTGACCGAGAGGGAAGCGATGCCACGGGAGATGGA
ACCAAGGAGAAACCATTTAAAACAGGTCTAAAGGCTTTGATGACAGTAGGGAAAGAACCA
TTTCCTACCATTTACGTAGATTCACAAAAAGAAAATGAGAGGTGGAATGTTATTTCTAAA
TCACAGTTGAAGAACATTAAAAAGATGTGGCATAGGGAACAAATGAAGAGTGAATCCCGG
GAAAAGAAAGAGGCAGAAGATAGTTTACGAAGAGAAAAGAACCTGGAAGAAGCAAAGAAG
ATTACCATTAAAAATGATCCAAGTCTCCCAGAGCCAAAATGTGTGAAGATTGGTGCGTTA
GAAGGATATAGAGGCCAAAGAGTAAAGGTGTTTGGCTGGGTCCACAGGCTGCGCAGGCAA
GGAAAGAATTTAATGTTTCTGGTGTTGCGAGATGGTACAGGTTATCTTCAGTGTGTCTTG
GCGGATGAGTTGTGTCAGTGCTACAATGGAGTTCTCTTGTCCACGGAGAGCAGTGTTGCA
GTGTATGGAATGCTAAATCTTACCCCAAAGGGCAAGCAGGCTCCAGGTGGCCATGAGCTG
AGTTGTGACTTCTGGGAACTAATTGGGTTGGCCCCTGCTGGAGGAGCTGACAACCTGATC
AATGAGGAGTCTGACGTTGATGTCCAGCTCAACAACAGACACATGATGATCCGAGGAGAA
AACATGTCCAAAATCCTAAAAGCACGATCCATGGTCACCAGGTGCTTTAGAGATCACTTC
TTTGATAGGGGGTACTATGAAGTTACTCCTCCAACATTAGTGCAAACACAAGTAGAAGGT
GGTGCCACACTCTTCAAGCTTGACTATTTTGGGGAAGAGGCATTTTTGACTCAATCCTCT
CAGTTGTACTTGGAGACCTGCCTCCCAGCCCTGGGAGATGTTTTTTGTATTGCTCAGTCA
TACCGGGCAGAGCAGTCCAGAACACGAAGGCACCTGGCTGAGTACACTCACGTGGAAGCT
GAGTGTCCTTTCCTGACTTTTGACGACCTCCTGAACCGGTTGGAGGACTTGGTTTGTGAT
GTGGTAGATCGAATATTGAAGTCACCTGCAGGGAGCATAGTGCATGAGCTCAACCCGAAC
TTTCAGCCCCCCAAACGGCCTTTCAAACGGATGAACTATTCAGATGCTATCGTTTGGCTA
AAAGAACATGATGTAAAGAAAGAAGATGGAACTTTCTATGAATTTGGAGAAGATATCCCA
GAAGCTCCTGAGAGACTGATGACAGACACCATTAATGAACCAATCTTGCTGTGTCGATTT
CCTGTGGAGATCAAGTCCTTCTACATGCAGCGATGTCCTGAGGATTCCCGTCTTACTGAA
TCTGTCGACGTGTTGATGCCCAATGTTGGTGAGATTGTGGGAGGCTCAATGCGTATCTTT
GATAGTGAAGAAATACTGGCAGGTTATAAAAGGGAAGGGATTGACCCCACTCCCTATTAC
TGGTATACGGATCAGAGAAAATACGGTACATGTCCCCATGGAGGATATGGCTTGGGCTTG
GAACGATTCTTAACGTGGATTCTGAATAGGTATCACATCCGAGACGTGTGCTTATACCCT
CGATTTGTCCAGCGTTGCACGCCATAA

# Metabolic_Enzyme_65_GenBank_ID_Gene:
AJ000334

# Metabolic_Enzyme_65_Chromosome_Location:
Not Available

# Metabolic_Enzyme_65_Locus:
Not Available

# Metabolic_Enzyme_65_SNPs:
Not Available

# Metabolic_Enzyme_65_General_References:
9421509; 9801298

# Metabolic_Enzyme_65_References:
Not Available

# Metabolic_Enzyme_66_ID:
5884

# Metabolic_Enzyme_66_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B

# Metabolic_Enzyme_66_Synonyms:
Not Available

# Metabolic_Enzyme_66_Gene_Name:
PDE7B

# Metabolic_Enzyme_66_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 7
BMSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTY
SGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDI
FLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAA
DVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNM
SVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH
NKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEI
SPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPR
QHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

# Metabolic_Enzyme_66_Number_of_Residues:
450

# Metabolic_Enzyme_66_Molecular_Weight:
51836

# Metabolic_Enzyme_66_Theoretical_pI:
7.03

# Metabolic_Enzyme_66_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_66_General_Function:
Not Available

# Metabolic_Enzyme_66_Specific_Function:
May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain

# Metabolic_Enzyme_66_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_66_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_66_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_66_Signals:
None

# Metabolic_Enzyme_66_Transmembrane_Regions:
None

# Metabolic_Enzyme_66_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_66_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_66_GenBank_ID_Protein:
8439497

# Metabolic_Enzyme_66_SwissProt_ID:
PDE7B_HUMAN (Q9NP56)

# Metabolic_Enzyme_66_swissprot_Name:
Not Available

# Metabolic_Enzyme_66_Genecard_id:
PDE7B

# Metabolic_Enzyme_66_Geneatlas_id:
PDE7B

# Metabolic_Enzyme_66_hgnc_id:
HGNC:8792

# Metabolic_Enzyme_66_PDB_ID:
Not Available

# Metabolic_Enzyme_66_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_66_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_66_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_66_Gene_Sequence:
>1353 bp
ATGTCTTGTTTAATGGTTGAGAGGTGTGGCGAAATCTTGTTTGAGAACCCCGATCAGAAT
GCCAAATGTGTTTGCATGCTGGGAGATATACGACTAAGGGGTCAGACGGGGGTTCGTGCT
GAACGCCGTGGCTCCTACCCATTCATTGACTTCCGCCTACTTAACAGTACAACATACTCA
GGGGAGATTGGCACCAAGAAAAAGGTGAAAAGACTATTAAGCTTTCAAAGATACTTCCAT
GCATCAAGGCTGCTTCGTGGAATTATACCACAAGCCCCTCTGCACCTGCTGGATGAAGAC
TACCTTGGACAAGCAAGGCATATGCTCTCCAAAGTGGGAATGTGGGATTTTGACATTTTC
TTGTTTGATCGCTTGACAAATGGAAACAGCCTGGTAACACTGTTGTGCCACCTCTTCAAT
ACCCATGGACTCATTCACCATTTCAAGTTAGATATGGTGACCTTACACCGATTTTTAGTC
ATGGTTCAAGAAGATTACCACAGCCAAAACCCGTATCACAATGCTGTTCACGCAGCCGAC
GTCACCCAGGCCATGCACTGCTACCTGAAAGAGCCAAAGCTTGCCAGCTTCCTCACGCCT
CTGGACATCATGCTTGGACTGCTGGCTGCAGCAGCACACGATGTGGACCACCCAGGGGTG
AACCAGCCATTTTTGATAAAAACTAACCACCATCTTGCAAACCTATATCAGAATATGTCT
GTGCTGGAGAATCATCACTGGCGATCTACAATTGGCATGCTTCGAGAATCAAGGCTTCTT
GCTCATTTGCCAAAGGAAATGACACAGGATATTGAACAGCAGCTGGGCTCCTTGATCTTG
GCAACAGACATCAACAGGCAGAATGAATTTTTGACCAGATTGAAAGCTCACCTCCACAAT
AAAGACTTAAGACTGGAGGATGCACAGGACAGGCACTTTATGCTTCAGATCGCCTTGAAG
TGTGCTGACATTTGCAATCCTTGTAGAATCTGGGAGATGAGCAAGCAGTGGAGTGAAAGG
GTCTGTGAAGAATTCTACAGGCAAGGTGAACTTGAACAGAAATTTGAACTGGAAATCAGT
CCTCTTTGTAATCAACAGAAAGATTCCATCCCTAGTATACAAATTGGTTTCATGAGCTAC
ATCGTGGAGCCGCTCTTCCGGGAATGGGCCCATTTCACGGGTAACAGCACCCTGTCGGAG
AACATGCTGGGCCACCTCGCACACAACAAGGCCCAGTGGAAGAGCCTGTTGCCCAGGCAG
CACAGAAGCAGGGGCAGCAGTGGCAGCGGGCCTGACCACGACCACGCAGGCCAAGGGACT
GAGAGCGAGGAGCAGGAAGGCGACAGCCCCTAG

# Metabolic_Enzyme_66_GenBank_ID_Gene:
AB038040

# Metabolic_Enzyme_66_Chromosome_Location:
Not Available

# Metabolic_Enzyme_66_Locus:
Not Available

# Metabolic_Enzyme_66_SNPs:
Not Available

# Metabolic_Enzyme_66_General_References:
10814504; 10872825

# Metabolic_Enzyme_66_References:
Not Available

# Metabolic_Enzyme_67_ID:
5234

# Metabolic_Enzyme_67_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_67_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_67_Gene_Name:
NT5C

# Metabolic_Enzyme_67_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_67_Number_of_Residues:
201

# Metabolic_Enzyme_67_Molecular_Weight:
23383

# Metabolic_Enzyme_67_Theoretical_pI:
6.63

# Metabolic_Enzyme_67_GO_Classification:
Not Available

# Metabolic_Enzyme_67_General_Function:
Not Available

# Metabolic_Enzyme_67_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_67_Pathway:
Not Available

# Metabolic_Enzyme_67_Reaction:
Not Available

# Metabolic_Enzyme_67_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_67_Signals:
None

# Metabolic_Enzyme_67_Transmembrane_Regions:
None

# Metabolic_Enzyme_67_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_67_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_67_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_67_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_67_swissprot_Name:
Not Available

# Metabolic_Enzyme_67_Genecard_id:
NT5C

# Metabolic_Enzyme_67_Geneatlas_id:
NT5C

# Metabolic_Enzyme_67_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_67_PDB_ID:
Not Available

# Metabolic_Enzyme_67_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_67_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_67_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_67_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_67_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_67_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_67_Locus:
17q25.1

# Metabolic_Enzyme_67_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_67_General_References:
10681516; 12234672

# Metabolic_Enzyme_67_References:
Not Available

# Metabolic_Enzyme_68_ID:
5885

# Metabolic_Enzyme_68_Name:
Lysyl-tRNA synthetase

# Metabolic_Enzyme_68_Synonyms:
Lysine--tRNA ligase; LysRS

# Metabolic_Enzyme_68_Gene_Name:
KARS

# Metabolic_Enzyme_68_Protein_Sequence:
>LysyltRNA synthetase
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV

# Metabolic_Enzyme_68_Number_of_Residues:
597

# Metabolic_Enzyme_68_Molecular_Weight:
68049

# Metabolic_Enzyme_68_Theoretical_pI:
6.31

# Metabolic_Enzyme_68_GO_Classification:
>>>
Function:  lysine-tRNA ligase activity
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  lysyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_68_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_68_Specific_Function:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_68_Pathway:
map00300  Lysine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_68_Reaction:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

# Metabolic_Enzyme_68_Pfam_Domain_Function:
PF00152:tRNA-synt_2;
PF01336:tRNA_anti

# Metabolic_Enzyme_68_Signals:
None

# Metabolic_Enzyme_68_Transmembrane_Regions:
None

# Metabolic_Enzyme_68_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_68_EC_Link:
EC 6.1.1.6

# Metabolic_Enzyme_68_GenBank_ID_Protein:
505108

# Metabolic_Enzyme_68_SwissProt_ID:
SYK_HUMAN (Q15046)

# Metabolic_Enzyme_68_swissprot_Name:
Not Available

# Metabolic_Enzyme_68_Genecard_id:
KARS

# Metabolic_Enzyme_68_Geneatlas_id:
KARS

# Metabolic_Enzyme_68_hgnc_id:
HGNC:6215

# Metabolic_Enzyme_68_PDB_ID:
Not Available

# Metabolic_Enzyme_68_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_68_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_68_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_68_Gene_Sequence:
>1808 bp
GGCCCTCCGGGAAGATGGCGGCCGTGCAGGCGGCCGAGGTGAAAGTGGATGGCAGCGAGC
CGAAACTGAGCAAGAATGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGA
AGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAGCTAAGCCAAGCCACTGCTGCTGCCA
CCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAAT
ACTACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACC
CACACAAGTTCCATGTAGACATCTCACTCACTGACTTCATCCAAAAATATAGTCACCTGC
AGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAA
GAGCTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAG
TCATGGCCAATTCCAGAAATTATAAATCAGAAGAAGAATTTATTCATATTAATAACAAAC
TGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGC
TGAGCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATC
TTCACTTTGGCCTCAAAGACAAGGAAACAAGGTATCGCCAGAGATACTTGGACTTGATCC
TGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAA
GTTTCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAG
GGGGAGCCGTGGCCAAGCCTTTCATCACTTATCACAACGAGCTGGACATGAACTTATATA
TGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTT
ATGAAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCA
CCACCTGTGAGTTCTACATGGCCTATGCAGACTATCACGATCTCATGGAAATCACGGAGA
AGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAG
ATGGCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACA
TGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAGCTGCCAGAAACGAACCTCTTTGAAA
CTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTC
CACCTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTT
GCATCAATCCTACATTCATCTGTGATCACCCACAGATAATGAGCCCTTTGGCTAAATGGC
ACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATAT
GCAATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGG
CCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATGTTCATAGATGAAAACTTCTGTACTG
CCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCA
TGTTTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCG
AAGACAAGAAGGAGAATGTAGCAACCACTGATACACTGGAAAGCACAACAGTTGGCAGTT
CTGTCTAG

# Metabolic_Enzyme_68_GenBank_ID_Gene:
D31890

# Metabolic_Enzyme_68_Chromosome_Location:
Not Available

# Metabolic_Enzyme_68_Locus:
Not Available

# Metabolic_Enzyme_68_SNPs:
Not Available

# Metabolic_Enzyme_68_General_References:
7584044; 9278442

# Metabolic_Enzyme_68_References:
Not Available

# Metabolic_Enzyme_69_ID:
5886

# Metabolic_Enzyme_69_Name:
Isoleucyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_69_Synonyms:
Isoleucine--tRNA ligase; IleRS; IRS

# Metabolic_Enzyme_69_Gene_Name:
IARS

# Metabolic_Enzyme_69_Protein_Sequence:
>IsoleucyltRNA synthetase, cytoplasmic
MSNKMLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHY
GHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEY
NNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV
KVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAV
CVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYF
LKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASG
CFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF
VRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFE
EVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYA
QVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLAS
DGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPW
YNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRL
YTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFL
TELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIR
DRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEP
DHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATG
GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAK
SEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLP
GPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDET
EIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLL
ENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVL
PTTADF

# Metabolic_Enzyme_69_Number_of_Residues:
1266

# Metabolic_Enzyme_69_Molecular_Weight:
144960

# Metabolic_Enzyme_69_Theoretical_pI:
6.10

# Metabolic_Enzyme_69_GO_Classification:
>>>
Function:  isoleucine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  isoleucyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_69_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_69_Specific_Function:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_69_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_69_Reaction:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

# Metabolic_Enzyme_69_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00133:tRNA-synt_1

# Metabolic_Enzyme_69_Signals:
None

# Metabolic_Enzyme_69_Transmembrane_Regions:
None

# Metabolic_Enzyme_69_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_69_EC_Link:
EC 6.1.1.5

# Metabolic_Enzyme_69_GenBank_ID_Protein:
551622

# Metabolic_Enzyme_69_SwissProt_ID:
SYIC_HUMAN (P41252)

# Metabolic_Enzyme_69_swissprot_Name:
Not Available

# Metabolic_Enzyme_69_Genecard_id:
IARS

# Metabolic_Enzyme_69_Geneatlas_id:
IARS

# Metabolic_Enzyme_69_hgnc_id:
HGNC:5330

# Metabolic_Enzyme_69_PDB_ID:
Not Available

# Metabolic_Enzyme_69_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_69_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_69_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_69_Gene_Sequence:
>3801 bp
ATGAGCAACAAAATGCTTCAACAAGTTCCAGAAAACATAAATTTTCCTGCTGAAGAAGAG
AAAATCTTGGAGTTTTGGACTGAATTTAATTGTTTTCAGGAATGCTTAAAGCAATCAAAA
CATAAACCAAAATTTACCTTCTATGATGGTCCTCCTTTTGCAACTGGACTGCCTCACTAT
GGACATATACTTGCGGGTACAATTAAAGATATAGTTACAAGATATGCTCACCAGAGTGGG
TTTCATGTTGACAGAAGATTTGGATGGGATTGCCATGGCTTACCTGTGGAATATGAAATT
GATAAGACACTGGGAATCAGAGGACCAGAGGATGTGGCCAAAATGGGGATTACAGAGTAT
AACAATCAGTGCCGAGCAATTGTGATGAGATATTCTGCTGAGTGGAAGTCTACTGTTAGC
AGACTTGGCCGATGGATTGACTTTGACAATGACTATAAAACTCTGTATCCACAATTCATG
GAATCAGTCTGGTGGGTCTTCAAACAACTCTATGATAAAGGCCTTGTTTATAGAGGTGTG
AAAGTCATGCCCTTCTCTACGGCATGTAACACTCCACTTTCCAACTTCGAGTCACACCAG
AATTATAAGGATGTTCAAGATCCTTCAGTATTTGTAACTTTCCCTTTGGAAGAAGATGAA
ACTGTATCTTTAGTTGCTTGGACAACCACTCCCTGGACTCTACCTAGTAACCTTGCTGTG
TGTGTTAATCCAGAAATGCAATATGTGAAAATTAAAGATGTTGCCAGAGGACGATTACTC
ATTTTAATGGAAGCCAGATTGTCAGCCCTCTATAAATTGGAGAGTGACTATGAGATCCTT
GAAAGATTTCCTGGTGCCTATCTTAAAGGCAAGAAGTACAGGCCCCTGTTTGACTATTTC
CTGAAGTGTAAAGAGAATGGCGCTTTCACTGTGCTTGTTGACAACTATGTGAAGGAAGAA
GAAGGCACAGGGGTTGTCCACCAAGCTCCTTACTTCGGTGCTGAGGACTATCGGGTCTGT
ATGGACTTTAACATTATTCGGAAAGACTCACTCCCTGTTTGCCCTGTGGATGCTTCAGGC
TGCTTCACAACGGAGGTGACAGATTTCGCAGGACAGTATGTGAAGGATGCTGACAAAAGT
ATCATCAGGACTTTGAAGGAACAAGGCCGACTTCTGGTTGCCACCACCTTCACTCACAGC
TACCCTTTTTGCTGGAGATCAGACACTCCTCTAATTTACAAAGCAGTGCCCAGCTGGTTT
GTGCGAGTGGAGAACATGGTGGACCAGCTCCTAAGGAACAATGACCTGTGCTACTGGGTC
CCAGAGTTGGTACGAGAAAAACGATTTGGAAATTGGCTGAAAGATGCACGTGACTGGACA
ATTTCCAGAAACAGATACTGGGGCACCCCCATCCCACTGTGGGTCAGCGATGACTTTGAG
GAGGTGGTATGCATTGGGTCAGTGGCGGAACTTGAAGAACTGTCAGGAGCAAAGATCTCA
GATCTCCACAGAGAGAGTGTTGACCACCTGACCATTCCTTCACGCTGTGGGAAGGGATCC
TTGCACCGCATCTCTGAAGTGTTTGACTGTTGGTTTGAGAGTGGCAGCATGCCCTATGCT
CAGGTTCATTACCCGTTTGAAAACAAGAGGGAGTTTGAGGATGCTTTTCCTGCAGATTTC
ATTGCCGAGGGCATCGACCAAACCAGAGGATGGTTTTATACCCTGCTGGTGCTGGCCACG
GCCCTCTTTGGACAACCGCCTTTCAAGAACGTAATTGTGAATGGGCTTGTCCTGGCAAGT
GATGGCCAAAAAATGAGCAAACGGAAAAAGAATTATCCAGATCCAGTTTCCATCATCCAG
AAGTATGGTGCTGATGCCCTCAGATTATATCTGATTAACTCCCCTGTGGTGAGAGCAGAA
AACCTCCGCTTTAAAGAAGAGGGTGTGCGGGACGTCCTTAAGGATGTACTGCTCCCATGG
TACAATGCCTATCGCTTCTTAATCCAGAACGTTCTGAGGCTCCAGAAGGAGGAAGAAATA
GAATTTCTCTACAATGAGAACACGGTTAGAGAAAGCCCCAACATTACAGACCGGTGGATC
CTGTCCTTCATGCAGTCTCTCATTGGCTTCTTTGAGACTGAAATGGCAGCTTATAGGCTT
TATACTGTGGTGCCTCGCCTGGTCAAGTTTGTAGATATTCTGACCAATTGGTATGTTAGA
ATGAACCGCAGAAGATTAAAGGGTGAAAATGGGATGGAGGATTGTGTCATGGCCCTAGAA
ACCTTGTTTAGTGTTCTGCTTTCTCTTTGCAGACTTATGGCTCCCTACACACCTTTTCTC
ACTGAATTGATGTACCAGAATCTAAAGGTGCTGATTGACCCTGTTTCTGTTCAGGACAAG
GACACACTCAGCATTCACTACCTCATGCTGCCCCGTGTTCGAGAAGAATTGATTGACAAG
AAAACAGAGAGTGCAGTATCTCAGATGCAGTCTGTGATTGAACTTGGAAGAGTGATCAGA
GACCGAAAAACTATTCCCATAAAGTATCCTTTGAAAGAAATTGTGGTTATCCATCAAGAT
CCAGAAGCTCTTAAAGATATCAAGTCTTTGGAGAAGTATATCATTGAGGAACTCAATGTT
CGAAAAGTTACACTGTCTACAGATAAAAACAAGTATGGCATTCGGCTAAGGGCAGAACCA
GATCACATGGTCCTGGGGAAGCGTCTGAAGGGAGCCTTTAAGGCAGTGATGACGTCCATC
AAGCAGTTGAGCAGTGAGGAGCTGGAGCAGTTCCAGAAGACTGGGACCATTGTTGTGGAA
GGCCATGAATTGCACGATGAAGACATCCGCCTCATGTACACCTTTGATCAGGCCACAGGT
GGGACTGCGCAATTTGAAGCACACTCAGATGCTCAGGCTTTGGTCCTCTTAGATGTCACT
CCTGACCAGTCAATGGTAGATGAAGGAATGGCTCGGGAAGTCATCAATCGCATACAGAAA
CTTCGCAAAAAGTGCAATCTGGTTCCAACTGATGAAATCACAGTGTACTATAAAGCAAAG
TCTGAAGGAACATATCTGAATAGTGTTATTGAAAGCCACACAGAGTTCATATTTACCACC
ATAAAGGCTCCCTTGAAACCATATCCAGTTTCTCCATCGGATAAAGTCCTTATTCAAGAA
AAAACACAGTTGAAGGGATCTGAACTGGAAATTACACTCACCAGAGGATCTTCCCTTCCT
GGTCCTGCTTGTGCATATGTCAATCTTAACATTTGTGCAAATGGCAGTGAACAAGGTGGA
GTATTGCTCCTGGAAAATCCAAAAGGTGACAATAGGTTGGACCTTTTAAAGCTGAAGAGT
GTTGTCACTAGCATTTTTGGTGTGAAAAATACAGAGCTGGCTGTCTTCCATGATGAAACA
GAAATACAAAACCAAACTGACTTACTGAGTCTTAGTGGAAAAACACTTTGTGTGACTGCA
GGATCGGCTCCCTCTCTGATCAACAGTTCTAGTACTCTTCTTTGTCAGTATATCAACCTA
CAGCTCCTGAATGCAAAGCCACAAGAGTGTTTAATGGGGACAGTGGGCACTCTCCTGCTT
GAAAACCCACTTGGGCAGAATGGACTCACCCACCAAGGTCTTCTGTATGAAGCAGCCAAG
GTGTTTGGCCTTCGGAGCAGGAAGCTAAAGCTGTTTCTGAATGAGACCCAAACGCAGGAA
ATTACAGAAGACATCCCCGTGAAGACTTTGAATATGAAGACTGTGTATGTTTCTGTGTTA
CCAACAACAGCAGACTTCTAG

# Metabolic_Enzyme_69_GenBank_ID_Gene:
D28473

# Metabolic_Enzyme_69_Chromosome_Location:
Not Available

# Metabolic_Enzyme_69_Locus:
Not Available

# Metabolic_Enzyme_69_SNPs:
Not Available

# Metabolic_Enzyme_69_General_References:
8052601; 7721108

# Metabolic_Enzyme_69_References:
Not Available

# Metabolic_Enzyme_70_ID:
5612

# Metabolic_Enzyme_70_Name:
Glycogen phosphorylase, brain form

# Metabolic_Enzyme_70_Synonyms:
Not Available

# Metabolic_Enzyme_70_Gene_Name:
PYGB

# Metabolic_Enzyme_70_Protein_Sequence:
>Glycogen phosphorylase, brain form
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTV
RDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDL
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEA
DDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVN
TMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKV
DWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFP
GDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKF
QNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQ
ENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFV
PRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPA
ADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVE
ALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEA
YMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNI
PRD

# Metabolic_Enzyme_70_Number_of_Residues:
843

# Metabolic_Enzyme_70_Molecular_Weight:
96697

# Metabolic_Enzyme_70_Theoretical_pI:
6.85

# Metabolic_Enzyme_70_GO_Classification:
>>>
Function:  binding
Function:  vitamin binding
Function:  pyridoxal phosphate binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
Function:  phosphorylase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_70_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_70_Specific_Function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

# Metabolic_Enzyme_70_Pathway:
map00500  Starch and sucrose metabolism

# Metabolic_Enzyme_70_Reaction:
(1,4-alpha-D-glucosyl)n + phosphate = (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate

# Metabolic_Enzyme_70_Pfam_Domain_Function:
PF00343:Phosphorylase

# Metabolic_Enzyme_70_Signals:
None

# Metabolic_Enzyme_70_Transmembrane_Regions:
None

# Metabolic_Enzyme_70_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_70_EC_Link:
EC 2.4.1.1

# Metabolic_Enzyme_70_GenBank_ID_Protein:
307200

# Metabolic_Enzyme_70_SwissProt_ID:
PYGB_HUMAN (P11216)

# Metabolic_Enzyme_70_swissprot_Name:
Not Available

# Metabolic_Enzyme_70_Genecard_id:
PYGB

# Metabolic_Enzyme_70_Geneatlas_id:
PYGB

# Metabolic_Enzyme_70_hgnc_id:
HGNC:9723

# Metabolic_Enzyme_70_PDB_ID:
Not Available

# Metabolic_Enzyme_70_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_70_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_70_Subcellular_Location:
Not Available

# Metabolic_Enzyme_70_Gene_Sequence:
>2592 bp
ATGGGCGAACCGCTGACGGACAGCGAGAAGCGGAAGCAGATCAGCGTGCGCGGCCTGGCG
GGGCTAGGCGACGTGGCCGAGGTGCGGAAGAGCTTCAACCGGCACTTGCACTTCACGCTG
GTCAAGGACCGCAATGTGGCCACGCCCCGCGACTACTTCTTCGCGCTGGCGCACACGGTG
CGCGACCACCTCGTGGGCCGCTGGATCCGCACGCAGCAGCACTACTACGAGCGCGACCCC
AAGCGAATTTATTATCTTTCCCTGGAATTCTACATGGGTCGCACGCTGCAGAACACGATG
GTGAACCTGGGCCTTCAGAATGCCTGCGATGAAGCCATCTATCAGTTGGGGTTAGACTTG
GAGGAACTCGAGGAGATAGAAGAAGATGCTGGCCTTGGGAATGGAGGCCTGGGGAGGCTG
GCAGCGTGTTTCCTTGACTCAATGGCTACCTTGGGCCTGGCAGCATACGGCTATGGAATC
CGCTATGAATTTGGGATTTTTAACCAGAAGATTGTCAATGGCTGGCAGGTAGAGGAGGCC
GATGACTGGCTGCGCTACGGCAACCCCTGGGAGAAAGCGCGGCCTGAGTATATGCTTCCC
GTGCACTTCTACGGACGCGTGGAGCACACCCCCGACGGCGTGAAGTGGCTGGACACACAG
GTGGTGCTGGCCATGCCCTACGACACCCCAGTGCCCGGCTACAAGAACAACACCGTCAAC
ACCATGCGGCTGTGGTCCGCAAGGGCTCCCAACGACTTCAAGCTGCAGGACTTCAACGTG
GGAGACTACATCGAGGCGGTCCTGGACCGGAACTTGGCTGAGAACATCTCCAGGGTCCTG
TATCCAAATGATAACTTCTTTGAGGGGAAGGAGCTGCGGCTGAAGCAGGAGTACTTCGTG
GTGGGCGCCACGCTCCAGGACATCATCCGCCGCTTCAAGTCGTCCAAGTTCGGCTGCCGG
GACCCTGTGAGAACCTGTTTCGAGACGTTCCCAGACAAGGTGGCCATCCAGCTGAACGAC
ACCCACCCCGCCCTCTCCATCCCTGAGCTCATGCGGATCCTGGTGGACGTGGAGAAGGTG
GACTGGGACAAGGCCTGGGAAATCACGAAGAAGACCTGTGCATACACCAACCACACTGTG
CTGCCTGAGGCCTTGGAGCGCTGGCCCGTGTCCATGTTTGAGAAGCTGCTGCCGCGGCAC
CTGGAGATAATCTATGCCATCAACCAGCGGCACCTGGACCACGTGGCCGCGCTGTTTCCC
GGCGATGTGGACCGCCTGCGCAGGATGTCTGTGATCGAGGAGGGGGACTGCAAGCGGATC
AACATGGCCCACCTGTGTGTGATTGGGTCCCATGCTGTCAATGGTGTGGCGAGGATCCAC
TCGGAGATCGTGAAACAGTCGGTCTTTAAGGATTTTTATGAACTGGAGCCAGAGAAGTTC
CAGAATAAGACCAATGGCATCACCCCCCGCCGGTGGCTGCTGCTGTGCAACCCGGGGCTG
GCCGATACCATCGTGGAGAAAATTGGGGAGGAGTTCCTGACTGACCTGAGCCAGCTGAAG
AAGCTGCTGCCGCTGGTCAGTGACGAGGTGTTCATCAGGGACGTGGCCAAGGTCAAACAG
GAGAACAAGCTCAAGTTCTCGGCCTTCCTGGAGAAGGAGTACAAGGTGAAGATCAACCCC
TCCTCCATGTTCGATGTGCATGTGAAGAGGATCCACGAGTACAAGCGGCAGCTGCTCAAC
TGCCTGCACGTCGTCACCCTGTACAATCGAATCAAGAGAGACCCGGCCAAGGCTTTTGTG
CCCAGGACTGTTATGATTGGGGGCAAGGCAGCGCCCGGTTACCACATGGCCAAGCTGATC
ATCAAGTTGGTCACCTCCATCGGCGACGTCGTCAATCATGACCCAGTTGTGGGTGACAGG
TTGAAAGTGATCTTCCTGGAGAACTACCGTGTGTCCTTGGCTGAGAAAGTGATCCCGGCC
GCTGATCTGTCGCAGCAGATCTCCACTGCAGGCACCGAGGCCTCAGGCACAGGCAACATG
AAGTTCATGCTCAACGGGGCCCTCACCATCGGCACCATGGACGGCGCCAACGTGGAGATG
GCCGAGGAGGCCGGGGCCGAGAACCTCTTCATCTTCGGCCTGCGGGTGGAGGATGTCGAG
GCCTTGGACCGGAAAGGGTACAATGCCAGGGAGTACTACGACCACCTGCCCGAGCTGAAG
CAGGCCGTGGACCAGATCAGCAGTGGCTTTTTTTCTCCCAAGGAGCCAGACTGCTTCAAG
GACATCGTGAACATGCTGATGCACCATGACAGGTTCAAGGTGTTTGCAGACTATGAAGCC
TACATGCAGTGCCAGGCACAGGTGGACCAGCTGTACCGGAACCCCAAGGAGTGGACCAAG
AAGGTCATCAGGAACATCGCCTGCTCGGGCAAGTTCTCCAGTGACCGGACCATCACGGAG
TATGCACGGGAGATCTGGGGTGTGGAGCCCTCCGACCTGCAGCTTCAGCACCTGCCCCAC
CCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCACACATCTT
GCTATGTATTAG

# Metabolic_Enzyme_70_GenBank_ID_Gene:
J03544

# Metabolic_Enzyme_70_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_70_Locus:
20p11.2-p11.1

# Metabolic_Enzyme_70_SNPs:
rs2227891; rs2228976; rs2227892; rs2227890; rs2228977; rs16987612; rs6515626; rs6050486; rs2261720; rs2257808; rs2261109; rs910996; rs2424698; rs6050510; rs2261785; rs2424699; rs2257233; rs2261794; rs2257705; rs2261115; rs2261698; rs2257809; rs2281562; rs2257464; rs2261784; rs2260997; rs2474772; rs2257461; rs2424700; rs2261795; rs7269045; rs6050512; rs2261790; rs2261753; rs2261747; rs2257712; rs2474769; rs2257370; rs6050511; rs6037075; rs1555329; rs2258052; rs6115107; rs2281558; rs3787078; rs2258053; rs2145125; rs2258201; rs6107024; rs11697384; rs6115109; rs2257991; rs8118763; rs753009; rs910997; rs1555331; rs6107023; rs6115118; rs2258563; rs6050509; rs6050502; rs6037070; rs4813555; rs7273544; rs6115115; rs2257432; rs6115101; rs2281559; rs8184820; rs2474767; rs3787082; rs2424704; rs8116542; rs6050487; rs2424701; rs3787081; rs6138555; rs3787080; rs1555330; rs8124539; rs8114792; rs2500411; rs2258135; rs2474777; rs6115117; rs2257982; rs8120601; rs6115114; rs6107017; rs2474763; rs12624460; rs2257988; rs11087508; rs2474770; rs6037071; rs13038092; rs2500410; rs6050513; rs11087511; rs6132824; rs2474773; rs2424703; rs6050501; rs2387734; rs11699953; rs6076328; rs6050488; rs12624693; rs2145126; rs12625357; rs12625045; rs2474766; rs11697736; rs6107021; rs6132825; rs6115121; rs2500413; rs7274919; rs6037069; rs6115106; rs3002702; rs2474762; rs2257649; rs8115188; rs2180597; rs6115116; rs6050515; rs4815398; rs2257985; rs12624472; rs8125980; rs6107022; rs6107019; rs2258066; rs2258617; rs2273473; rs6138553; rs7274104; rs6132822; rs11549036; rs6037077; rs6115125; rs6115124; rs35481467; rs6050484; rs35073849; rs2228978; rs6115120; rs35669741; rs35189278; rs6083789; rs2474764; rs11474310; rs34233544; rs4619688; rs34170256; rs11483996; rs34871259; rs12625447; rs7272247; rs11472555; rs6083794; rs6115113; rs6115108; rs8125437; rs6050485; rs11472504; rs11471241; rs35760653; rs2254046; rs3838000; rs6050503; rs7274130; rs11473890; rs6050520; rs6083790; rs6050507; rs2180596; rs6115102; rs10582106; rs6115129; rs6037079; rs7353137; rs11466827; rs6050493; rs2474774; rs6050491; rs6107018; rs35358504; rs11468635; rs11468776; rs13043218; rs34067778; rs34827380; rs11475816; rs41282330; rs6138556; rs5841050; rs34496209; rs6050498; rs13043643; rs34360139; rs35375864; rs13044624; rs6107020; rs6138551; rs11699652; rs2474776; rs6115123; rs2474768; rs6050508; rs11312793; rs35716293; rs6115104; rs35058859; rs36105797; rs6050494; rs13433150; rs11470476; rs34346429; rs6050492; rs11471520; rs6115128; rs6115103; rs12106151; rs2983489; rs6050504; rs11468520; rs6083788; rs41282328; rs6050490; rs11087510; rs28770021; rs35286896; rs4364079; rs6050521; rs11475085; rs6138558; rs6037068; rs7352961; rs11480235; rs33973694; rs7269584; rs6115130; rs2983490; rs11350552; rs6115110; rs5841051; rs35988788; rs35243193; rs2281561; rs6050495; rs6138552; rs6076330; rs35609563; rs12626048; rs7363911; rs6083793; rs6115122; rs34299454; rs6115105; rs34646441; rs2474775; rs35264724; rs33964550; rs6050505; rs12625048; rs2474771; rs11477346; rs2500426; rs6050522; rs6050519; rs34336965; rs6138559; rs8114789; rs36117882; rs11470854; rs35760227; rs3841696; rs5841052; rs13433144; rs2281560; rs6050523; rs1118963; rs33999482; rs35370770; rs34672197; rs13038488; rs35258354; rs34316192; rs34427422; rs35256912; rs11479739; rs6037073; rs13043662; rs3787079; rs34204571; rs6083791; rs6115111; rs11908154; rs34776023; rs7272959; rs1077889; rs28881233; rs6083792; rs11480711; rs6138554; rs13037005; rs2474765; rs35263526; rs6050483; rs34955390; rs1046073; rs10966; rs1130694; rs11905042; rs2258719; rs2258769; rs2259873; rs2260197; rs2261796; rs2474779; rs2474780; rs6050471; rs6050473; rs6050475; rs6050476; rs6050477; rs6050481; rs6107016; rs6107027; rs6115098; rs6115100; rs7019; rs7344105; rs746748; rs8119343; rs9927

# Metabolic_Enzyme_70_General_References:
3346228; 2615594; 11780052; 12665801

# Metabolic_Enzyme_70_References:
Not Available

# Metabolic_Enzyme_71_ID:
5887

# Metabolic_Enzyme_71_Name:
Bis(5'-adenosyl)-triphosphatase

# Metabolic_Enzyme_71_Synonyms:
Diadenosine 5',5'''- P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; AP3A hydrolase; AP3AASE; Fragile histidine triad protein

# Metabolic_Enzyme_71_Gene_Name:
FHIT

# Metabolic_Enzyme_71_Protein_Sequence:
>Bis5'adenosyltriphosphatase
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ

# Metabolic_Enzyme_71_Number_of_Residues:
147

# Metabolic_Enzyme_71_Molecular_Weight:
16858

# Metabolic_Enzyme_71_Theoretical_pI:
7.09

# Metabolic_Enzyme_71_GO_Classification:
Not Available

# Metabolic_Enzyme_71_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_71_Specific_Function:
Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues

# Metabolic_Enzyme_71_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_71_Reaction:
P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP

# Metabolic_Enzyme_71_Pfam_Domain_Function:
PF01230:HIT

# Metabolic_Enzyme_71_Signals:
1-24

# Metabolic_Enzyme_71_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_71_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_71_EC_Link:
EC 3.6.1.29

# Metabolic_Enzyme_71_GenBank_ID_Protein:
1203836

# Metabolic_Enzyme_71_SwissProt_ID:
FHIT_HUMAN (P49789)

# Metabolic_Enzyme_71_swissprot_Name:
Not Available

# Metabolic_Enzyme_71_Genecard_id:
FHIT

# Metabolic_Enzyme_71_Geneatlas_id:
FHIT

# Metabolic_Enzyme_71_hgnc_id:
HGNC:3701

# Metabolic_Enzyme_71_PDB_ID:
1FHI

# Metabolic_Enzyme_71_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_71_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_71_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_71_Gene_Sequence:
>444 bp
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCTGTAGTGTTTCTCAAAACAGAA
CTGTCCTTCGCTCTTGTGAATAGGAAACCTGTGGTACCAGGACATGTCCTTGTGTGCCCG
CTGCGGCCAGTGGAGCGCTTCCATGACCTGCGTCCTGATGAAGTGGCCGATTTGTTTCAG
ACGACCCAGAGAGTCGGGACAGTGGTGGAAAAACATTTCCATGGGACCTCTCTCACCTTT
TCCATGCAGGATGGCCCCGAAGCCGGACAGACTGTGAAGCACGTTCACGTCCATGTTCTT
CCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACAT
GACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCA
GCTCTGCGGGTCTACTTTCAGTGA

# Metabolic_Enzyme_71_GenBank_ID_Gene:
U46922

# Metabolic_Enzyme_71_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_71_Locus:
3p14.2

# Metabolic_Enzyme_71_SNPs:
rs1385816; rs17255497; rs2077774; rs1569346; rs1735457; rs1385717; rs1550343; rs1009947; rs2682966; rs1716745; rs2205343; rs2118809; rs1562525; rs1735444; rs1001788; rs1447918; rs1716718; rs812965; rs1374916; rs1623091; rs2856071; rs1347852; rs967318; rs1735468; rs2856042; rs2736736; rs741891; rs1735469; rs2083264; rs2205352; rs2256806; rs1439006; rs1029277; rs2682931; rs939497; rs1439004; rs2365057; rs1371095; rs241697; rs1916801; rs180992; rs1524020; rs1735471; rs1447924; rs986687; rs721207; rs2682956; rs2594257; rs2736737; rs2886377; rs2044613; rs1880218; rs1735443; rs1898748; rs926139; rs2594135; rs967319; rs180994; rs1447926; rs2856036; rs1735460; rs1716748; rs2856072; rs2142294; rs2856056; rs1470035; rs762693; rs2856025; rs2856038; rs1966136; rs1839075; rs717228; rs2205353; rs2064012; rs2594159; rs939496; rs2885865; rs1447925; rs717762; rs2365045; rs760314; rs2682968; rs10866041; rs6782531; rs9876185; rs9843949; rs181003; rs7642017; rs4515043; rs2856034; rs6804627; rs241663; rs4679483; rs6776499; rs7649991; rs7653382; rs6445197; rs1562519; rs7648833; rs7651468; rs4688324; rs9841152; rs2682970; rs6787292; rs2856044; rs4974227; rs6446140; rs1350636; rs10510851; rs6803394; rs9840822; rs6786213; rs13098348; rs9882477; rs1554599; rs6446170; rs1439008; rs2049799; rs9857606; rs9821406; rs1562523; rs9879376; rs11130815; rs11130802; rs2856030; rs7641604; rs9878766; rs9754605; rs11917930; rs6783059; rs181349; rs11130807; rs9846267; rs2594145; rs7642143; rs7609861; rs2142296; rs9826128; rs1980309; rs6807877; rs2044611; rs2682954; rs6446179; rs9844741; rs9877396; rs4974255; rs6792544; rs11926787; rs11925038; rs9862895; rs1716753; rs4974235; rs11130777; rs6765136; rs2205351; rs2205360; rs928945; rs9311778; rs13070504; rs4309721; rs1868220; rs1972855; rs2365491; rs13320646; rs6765028; rs1007220; rs1371091; rs9851485; rs4974249; rs11130821; rs1821943; rs9836987; rs6773741; rs9849262; rs6769544; rs12492010; rs9828898; rs7610484; rs9311773; rs12107532; rs11130775; rs1597101; rs2682963; rs4688135; rs9811973; rs9832173; rs10451993; rs6789015; rs6797329; rs3937353; rs4688142; rs2100152; rs9827976; rs12635622; rs10510854; rs9852628; rs7649096; rs7616887; rs9850777; rs7653771; rs6788585; rs11130794; rs6791911; rs1447930; rs6774839; rs9879276; rs12107530; rs10866044; rs2736742; rs6763300; rs2856027; rs11130812; rs7645482; rs180995; rs11706821; rs2178808; rs9826800; rs2682967; rs6445192; rs1447921; rs1916800; rs1627302; rs7638403; rs9311790; rs6446149; rs9819076; rs1562524; rs11720214; rs7613542; rs6794160; rs6791496; rs11130813; rs7636370; rs2594123; rs7426804; rs7647122; rs2682971; rs9827069; rs10510852; rs2142041; rs1868225; rs6446175; rs13323296; rs7632868; rs11915345; rs2363667; rs11130804; rs9811235; rs6774194; rs6762641; rs6445194; rs11130816; rs9844497; rs7618351; rs1347853; rs6779985; rs1898750; rs1916802; rs6793385; rs5016304; rs6807748; rs9866844; rs4974236; rs4132221; rs6809125; rs7640756; rs9311768; rs7641177; rs7615191; rs9311777; rs9850125; rs1447919; rs2856055; rs2594130; rs9815092; rs11710207; rs940337; rs12054041; rs2121845; rs4129352; rs6773775; rs4679482; rs9832938; rs9842587; rs7629382; rs780375; rs7638130; rs9811056; rs9875844; rs9884072; rs7631246; rs9849709; rs7618762; rs7644694; rs9816087; rs9845743; rs4974256; rs9814846; rs7636357; rs1735461; rs6446157; rs9879362; rs6445196; rs2205350; rs9857754; rs2205349; rs3920477; rs6775612; rs9311775; rs6808414; rs1122667; rs939495; rs13100357; rs9823902; rs9311795; rs9863683; rs1900669; rs7371876; rs9814327; rs1978865; rs1447923; rs7616675; rs9875365; rs9754838; rs2594144; rs724025; rs1866433; rs9879848; rs9820332; rs9859201; rs1716734; rs9819588; rs11130776; rs2218088; rs9868891; rs11924304; rs2734368; rs4688310; rs9833215; rs7650937; rs6783115; rs10866046; rs9823013; rs6765371; rs241672; rs1623349; rs9861551; rs9870560; rs6777567; rs7619721; rs1716749; rs11926400; rs9820155; rs1349031; rs12107509; rs7640496; rs1716752; rs6772782; rs11916720; rs2363669; rs2734369; rs7644380; rs6772346; rs11130803; rs7617530; rs6775705; rs7636178; rs7652163; rs9311774; rs11130822; rs1821942; rs9853124; rs181001; rs2736741; rs10866045; rs6446173; rs180998; rs7617424; rs6445198; rs9820971; rs1980310; rs12107512; rs6446174; rs4974248; rs10510855; rs6446143; rs2165041; rs2255772; rs717291; rs11130782; rs1868226; rs1965143; rs12638248; rs9990051; rs9875228; rs6445191; rs2226972; rs1898752; rs9815151; rs6771383; rs7630291; rs1880213; rs9311779; rs12629814; rs6787897; rs7640419; rs2734365; rs2594134; rs1403968; rs6805412; rs7624678; rs12107986; rs2121858; rs4974239; rs7621722; rs11130820; rs12489758; rs6777650; rs10510849; rs6805796; rs6791644; rs2886257; rs7651235; rs9861707; rs6446150; rs2736745; rs6785030; rs6767314; rs9845774; rs4974241; rs2040378; rs2736740; rs2223084; rs6802326; rs1439001; rs1029276; rs1447927; rs7619248; rs11130800; rs12633258; rs9839019; rs9821525; rs9990356; rs12632664; rs7611169; rs9813580; rs9871451; rs7646223; rs11919495; rs17063911; rs7609667; rs2682930; rs9855931; rs9852553; rs17624325; rs1447914; rs11922368; rs17687956; rs2682979; rs7627621; rs11130785; rs12494672; rs9860076; rs12491463; rs9831324; rs4679481; rs9871598; rs7650309; rs2365059; rs9880554; rs1716705; rs1584341; rs1898749; rs17670088; rs6766713; rs6781958; rs9811304; rs11924124; rs12715562; rs4296587; rs2682984; rs1530093; rs2736738; rs9818351; rs2301156; rs17063986; rs10049287; rs7372683; rs4688293; rs12496064; rs2262951; rs1969420; rs12487370; rs10510858; rs2251707; rs9833533; rs9838172; rs9826649; rs735667; rs1947158; rs6446159; rs2736754; rs6805296; rs11716874; rs2247359; rs6777895; rs2736756; rs2594233; rs9832404; rs17681785; rs9819985; rs6797228; rs2594165; rs17063904; rs2006807; rs9880496; rs17683604; rs7627137; rs2734370; rs7616671; rs9832387; rs11712250; rs6785095; rs9819311; rs17064252; rs1735440; rs2594125; rs2856032; rs10049007; rs1123706; rs11925380; rs12489627; rs6792606; rs9840107; rs2856057; rs12631370; rs11711523; rs2682960; rs7631101; rs6802718; rs13087102; rs11130791; rs13098466; rs1735478; rs7432066; rs7610478; rs2856017; rs12630435; rs6782382; rs4688295; rs721779; rs9875504; rs1735462; rs2364295; rs1735475; rs9850400; rs2205345; rs6446165; rs4974229; rs6772819; rs6790615; rs11709041; rs1716747; rs9865619; rs11921290; rs17064029; rs9854653; rs4974230; rs4974254; rs10510856; rs2178809; rs11130798; rs4688352; rs11130817; rs2365052; rs9862715; rs2856068; rs11920498; rs7639157; rs6414609; rs9842471; rs181002; rs9856186; rs1716724; rs17064329; rs2736744; rs9845331; rs7650786; rs6446164; rs2252742; rs2594163; rs12492901; rs1839069; rs11130809; rs13317838; rs9857057; rs6792962; rs2736734; rs11917807; rs6794439; rs9816911; rs1554601; rs2594129; rs13060659; rs7650320; rs6793580; rs7652906; rs9836639; rs2682946; rs13093744; rs6446172; rs17679400; rs9819092; rs760315; rs11923137; rs9860669; rs12637393; rs2365054; rs6445190; rs2856037; rs2105829; rs10049454; rs9311769; rs11707666; rs6762099; rs9850904; rs1716737; rs11709918; rs7637553; rs1584337; rs6765479; rs12492395; rs6799902; rs17627738; rs1371093; rs11922845; rs9311792; rs6414610; rs1880212; rs2736755; rs9876579; rs7643970; rs2251704; rs17063920; rs6801782; rs2594158; rs7610999; rs17695525; rs11716931; rs11130796; rs6805904; rs9880898; rs2856021; rs17669863; rs6768933; rs4260356; rs11711479; rs2734366; rs9840473; rs17687542; rs7646749; rs9827045; rs6806667; rs1562520; rs6446136; rs6798786; rs13096204; rs9878801; rs2594161; rs10222378; rs17064630; rs6784732; rs17064395; rs10222544; rs9834435; rs1629179; rs6787313; rs2121857; rs11923145; rs12107589; rs10866043; rs1980311; rs11915333; rs2156974; rs9839778; rs6772523; rs9816492; rs11920478; rs9827591; rs11130833; rs1880214; rs6783370; rs6801658; rs9837947; rs7633853; rs12493259; rs7630746; rs2594141; rs10510864; rs13099522; rs9859690; rs2682951; rs1716722; rs11711708; rs4688350; rs1839070; rs7612949; rs12715565; rs6445195; rs9828177; rs12498118; rs17684830; rs12496007; rs2594157; rs9311771; rs7611737; rs1562522; rs6782022; rs7432943; rs6806415; rs9878020; rs9845200; rs11919041; rs1716714; rs9845837; rs6792330; rs241682; rs12487188; rs1716739; rs17031633; rs9864191; rs17669257; rs2121844; rs9846073; rs2044612; rs9871875; rs7429680; rs753662; rs6799513; rs17064093; rs2365485; rs6786392; rs6779150; rs2165040; rs7622298; rs753661; rs12715561; rs4574237; rs6790097; rs9875984; rs11130834; rs2594122; rs7627303; rs12493219; rs17064607; rs1839068; rs6446133; rs9849413; rs9827764; rs2205342; rs1595603; rs7642546; rs17632419; rs6446160; rs6762126; rs9878477; rs6786508; rs6789174; rs1839065; rs17628405; rs6809101; rs7640076; rs11130795; rs9843237; rs1735439; rs6795855; rs2226971; rs17637930; rs7639167; rs1716720; rs2736748; rs11712505; rs9856262; rs9839082; rs6801370; rs6809666; rs1980308; rs9311788; rs13065371; rs12638023; rs2886261; rs9816826; rs2594265; rs940338; rs10510848; rs7646887; rs9311772; rs17680010; rs7638831; rs13095530; rs17063507; rs9827340; rs11130811; rs9850713; rs12489122; rs17064094; rs7631974; rs6793095; rs6809331; rs7612453; rs13315187; rs9758127; rs1716732; rs9311781; rs17064337; rs13093215; rs12053964; rs11707984; rs9883165; rs11130818; rs2856018; rs2205344; rs7636682; rs11713112; rs1447959; rs4679480; rs7644525; rs12107501; rs13323679; rs6765664; rs6785709; rs2594132; rs10510857; rs171351; rs1584336; rs9860195; rs2856041; rs9864812; rs9841468; rs12487847; rs6446135; rs7653468; rs13093016; rs17063870; rs9820046; rs7645257; rs6772719; rs17063899; rs11921459; rs9847604; rs12498001; rs2365051; rs1439002; rs9311786; rs11707813; rs151737; rs2736743; rs6446178; rs9876711; rs6791680; rs2594164; rs9818734; rs9878248; rs9827254; rs1716717; rs11918370; rs12487927; rs17063778; rs4535219; rs11130825; rs2594137; rs9882068; rs11130789; rs9812158; rs1540263; rs6786595; rs7634868; rs2594166; rs6804478; rs13070093; rs1447928; rs17064185; rs7642109; rs12053817; rs6785140; rs2736749; rs9862122; rs9866904; rs180987; rs180999; rs10510859; rs2736732; rs11130790; rs9311770; rs9823201; rs9860640; rs6775908; rs6446171; rs9834766; rs7634073; rs12637792; rs9879191; rs1625810; rs7617867; rs9866093; rs17063532; rs2594152; rs13324938; rs2594139; rs2734350; rs6780515; rs9845479; rs2064011; rs11923043; rs9881065; rs4688351; rs6779250; rs1439005; rs2003793; rs2365058; rs17634797; rs2736733; rs13094165; rs9849474; rs9831680; rs2156973; rs12632698; rs11130793; rs241671; rs2856067; rs9861400; rs7653719; rs12152491; rs17670198; rs9853818; rs2736758; rs12633494; rs2365389; rs7625928; rs9826570; rs720000; rs11925426; rs12185984; rs7615687; rs9843007; rs9311776; rs241669; rs1823239; rs2682944; rs7651431; rs9834182; rs7633325; rs2165044; rs9869954; rs6791272; rs10048949; rs11130772; rs9811478; rs2682945; rs1716721; rs11715589; rs2682962; rs11926529; rs17064561; rs6788110; rs4688332; rs13063937; rs4974250; rs1716744; rs17064527; rs9861713; rs6793737; rs7631028; rs9860681; rs9825823; rs11712757; rs4315681; rs4974251; rs11705999; rs17064099; rs9837996; rs1530092; rs12492742; rs6768425; rs13088130; rs11929245; rs2856029; rs9830298; rs1665; rs1627398; rs7640909; rs9827312; rs10049452; rs9875651; rs12491786; rs12638171; rs11927024; rs7624552; rs17063990; rs13319380; rs1562521; rs9808931; rs17680697; rs1447917; rs6803624; rs11914567; rs10510853; rs2886260; rs13322666; rs11130780; rs9856859; rs11130805; rs7432088; rs2594254; rs9876863; rs2856045; rs17064259; rs9311791; rs17063517; rs7650123; rs1868223; rs1866434; rs11923899; rs10866042; rs9851616; rs6772800; rs9877318; rs1716709; rs2734367; rs9870497; rs12631593; rs11717799; rs7645898; rs10510850; rs9917755; rs9829212; rs9876876; rs12497257; rs12486280; rs9836897; rs180993; rs6788545; rs2205359; rs7646851; rs6446169; rs9851572; rs1158425; rs1524021; rs17064285; rs2363683; rs9819641; rs2118811; rs11711938; rs7626688; rs17624475; rs4974234; rs6446183; rs2682977; rs12495226; rs11922889; rs9842407; rs17064628; rs1618561; rs11130835; rs2856059; rs9857131; rs9859004; rs17064433; rs6799836; rs13068378; rs17668477; rs17063959; rs2028279; rs7645096; rs17063923; rs11929123; rs6768495; rs7645256; rs2855998; rs7651494; rs2594143; rs13322787; rs2856077; rs6788916; rs9311780; rs9831013; rs13074044; rs9942059; rs6783304; rs4571197; rs17686365; rs1595602; rs4688311; rs1716738; rs9867960; rs9814044; rs11130810; rs1374918; rs9825739; rs9829855; rs17063700; rs17064324; rs9820462; rs9849678; rs7652525; rs12491168; rs7618423; rs9840160; rs2856005; rs9880152; rs12492140; rs13079016; rs241683; rs7627681; rs939498; rs7645767; rs17064253; rs6793104; rs9809234; rs7637834; rs7630972; rs12629959; rs2003794; rs13078149; rs9848948; rs7637810; rs10510860; rs9829886; rs9847651; rs9821316; rs6776937; rs9871579; rs17632681; rs9839793; rs9872457; rs1735466; rs13323037; rs6798559; rs2367086; rs9840901; rs9682902; rs6762120; rs9850978; rs11710387; rs9311796; rs1839066; rs11923434; rs7618714; rs9839509; rs780374; rs7642882; rs1447929; rs12493843; rs11130819; rs6772308; rs11130826; rs7610879; rs6793486; rs9842893; rs13320670; rs9837423; rs7434129; rs7621451; rs17064381; rs9849061; rs9838335; rs12492551; rs9847761; rs11718033; rs9868814; rs13326569; rs11923559; rs1916799; rs12495145; rs9854694; rs6789900; rs9843597; rs9816751; rs1716733; rs4405865; rs6772908; rs715382; rs7626618; rs12490370; rs35143592; rs4688348; rs9799246; rs1716735; rs17063922; rs2736747; rs17635382; rs2213215; rs9868716; rs17063578; rs9846375; rs4974240; rs6797098; rs741892; rs6770423; rs11714760; rs2736731; rs1439003; rs7643144; rs9311794; rs13075102; rs17063883; rs13319645; rs2594167; rs9865739; rs9809371; rs12494967; rs7642517; rs12374031; rs17064507; rs2682949; rs242187; rs7641486; rs17064320; rs9864918; rs9828175; rs1473644; rs13088635; rs17031618; rs1898751; rs241674; rs6787511; rs4402933; rs2156969; rs7631695; rs12496920; rs11130783; rs12492849; rs13059280; rs17064615; rs9841262; rs7643503; rs12491629; rs13099398; rs17624499; rs11719227; rs1882897; rs7612963; rs17063617; rs6762122; rs2205348; rs9866066; rs2856039; rs9843759; rs2594138; rs9817302; rs6791660; rs6796003; rs9829652; rs9858680; rs241664; rs13314067; rs6809918; rs9848914; rs9879770; rs11706094; rs715381; rs4679549; rs2682981; rs11714398; rs17064510; rs1900668; rs17064090; rs7374200; rs7621672; rs12330767; rs7372419; rs9882800; rs1735445; rs9867019; rs6805291; rs13076604; rs17685850; rs9881274; rs2365050; rs7641121; rs17064336; rs9881340; rs12491965; rs9820533; rs2594147; rs12497528; rs9868743; rs2166814; rs2040377; rs241670; rs9831193; rs2594253; rs9814616; rs717292; rs9857165; rs9832941; rs2121859; rs1447922; rs17063813; rs9816956; rs9834262; rs2250114; rs9864149; rs9827546; rs1374919; rs2886256; rs7626576; rs4393862; rs2736750; rs4402886; rs6762597; rs1735449; rs2856076; rs2365042; rs17686275; rs1735453; rs9816210; rs13094263; rs9826131; rs9868863; rs13087545; rs12632702; rs2682969; rs4453834; rs17686079; rs17624439; rs13325669; rs13060326; rs13080485; rs11914648; rs6776343; rs17064521; rs9878383; rs9820196; rs9849906; rs11719785; rs17685796; rs4679555; rs13099811; rs6809031; rs17063494; rs7629014; rs6446182; rs9877774; rs2594119; rs17634592; rs6797229; rs17064044; rs9836650; rs9825016; rs3915074; rs13085845; rs2364300; rs17627239; rs9849318; rs9854360; rs9877573; rs6767530; rs12633756; rs2594273; rs2077099; rs11130792; rs7631312; rs6796455; rs2856033; rs241673; rs9818475; rs9829453; rs9858247; rs2736752; rs241677; rs17063973; rs6776129; rs11706057; rs9871813; rs11720347; rs17064394; rs11130836; rs7646138; rs13093251; rs9875066; rs1716729; rs1868222; rs7374239; rs4679548; rs7618397; rs13061562; rs9880620; rs17637725; rs9837219; rs1716726; rs9754707; rs12488640; rs1967348; rs2594149; rs6772360; rs17689493; rs2205358; rs13086399; rs12491075; rs2736746; rs11715779; rs17670946; rs9880322; rs6773644; rs9838372; rs7611105; rs11716427; rs12494269; rs17668356; rs17064660; rs17630955; rs17668266; rs9311799; rs13068401; rs7624473; rs2682976; rs9682234; rs12489644; rs17064663; rs13068278; rs1880216; rs7611232; rs7640515; rs7373003; rs17064482; rs961374; rs9876966; rs751252; rs2064013; rs6763941; rs13314073; rs34412028; rs4558709; rs12488704; rs7610473; rs17064608; rs11130781; rs9846162; rs6446138; rs6782953; rs17064657; rs6782111; rs2365049; rs7622539; rs13067370; rs9845924; rs6787793; rs2736759; rs1447916; rs4688361; rs9917837; rs7633753; rs9827827; rs7643657; rs13087596; rs6446161; rs12108196; rs13326701; rs2594151; rs9680926; rs17063998; rs502739; rs17064007; rs17630913; rs6808935; rs241685; rs7639878; rs7610331; rs11927051; rs17063678; rs12495135; rs9881064; rs6764320; rs7622729; rs11918601; rs9864410; rs7638707; rs9880158; rs6808123; rs9864591; rs17064309; rs9856644; rs7609688; rs12491171; rs17064303; rs1868221; rs9839700; rs6775530; rs9869424; rs11921624; rs9813886; rs12638876; rs7636351; rs17064187; rs13087524; rs11130799; rs6804167; rs1947159; rs9311797; rs9815842; rs11708288; rs2121843; rs2365492; rs6787911; rs17063868; rs1623840; rs7653023; rs4974246; rs2736753; rs12497605; rs34894181; rs9851252; rs6797465; rs11921411; rs4458323; rs6791206; rs1614618; rs7612282; rs9848705; rs13099397; rs4600784; rs7613524; rs2594142; rs1868228; rs6797125; rs7638056; rs11130801; rs17064638; rs17064508; rs9830950; rs1620446; rs6768016; rs7653005; rs6769253; rs3772442; rs17064318; rs6764332; rs1716719; rs11130806; rs7428745; rs1014856; rs9856559; rs17064511; rs1374917; rs7612462; rs17064323; rs13097786; rs13100376; rs9876067; rs7638932; rs9859251; rs9871619; rs13063948; rs1584340; rs6446162; rs10866040; rs1716706; rs4414847; rs17064379; rs4688146; rs9847513; rs1716710; rs9853773; rs180983; rs17063917; rs13085258; rs13084123; rs1005463; rs9882247; rs17063933; rs9880965; rs9819146; rs17064624; rs17685826; rs13071895; rs9855482; rs9865526; rs9844774; rs9827752; rs12487914; rs6797903; rs2166823; rs9858841; rs9853053; rs12486043; rs12491946; rs13074513; rs13066622; rs11921857; rs13090600; rs7636450; rs1735467; rs9880233; rs11130797; rs17063967; rs7626939; rs17063914; rs17063928; rs6808912; rs13067083; rs9847131; rs9871232; rs2118812; rs9843941; rs17064316; rs1735448; rs2156968; rs7643983; rs11715778; rs6787595; rs9820776; rs9881646; rs17064083; rs13073028; rs17063950; rs12498136; rs9850114; rs17063921; rs6768800; rs9879312; rs7640288; rs34045993; rs11714293; rs9755687; rs11921597; rs13323456; rs9868708; rs13093294; rs9875292; rs9840977; rs11715674; rs2594170; rs2213216; rs4256080; rs17063781; rs1735458; rs1735477; rs9823919; rs4117970; rs2886255; rs13100872; rs2246924; rs7633805; rs17685772; rs17063886; rs13095410; rs9838678; rs2142295; rs11926163; rs12497047; rs241675; rs11715704; rs2364293; rs7648908; rs9819767; rs11921655; rs11922545; rs7649286; rs9870639; rs7632682; rs1735479; rs6446184; rs12491421; rs9835901; rs1716740; rs9879049; rs2594171; rs7636127; rs9830935; rs17637774; rs9851218; rs1735470; rs9827553; rs7633027; rs12492639; rs13099063; rs2856040; rs2205347; rs17064357; rs11718931; rs9842721; rs1357639; rs13074190; rs13067855; rs9863189; rs9867295; rs2856047; rs2682974; rs17064182; rs4974253; rs2363670; rs11914311; rs4425247; rs1868224; rs17064314; rs17064653; rs9831393; rs6805502; rs12486851; rs9757313; rs9842102; rs9857504; rs9855480; rs9871019; rs6785032; rs4533645; rs1716723; rs9872622; rs9831698; rs6804218; rs9860688; rs9874458; rs17064376; rs6801955; rs9842547; rs6774523; rs9851737; rs1716713; rs1997582; rs17064028; rs242186; rs7613634; rs9852160; rs2083265; rs2091955; rs11711696; rs9863908; rs9868283; rs13085356; rs2856058; rs13080291; rs9856189; rs6446152; rs9311793; rs2118813; rs2594162; rs11927658; rs17064327; rs6445193; rs1447920; rs1123707; rs2682961; rs9866509; rs7612078; rs6764497; rs7636568; rs1447958; rs9834070; rs11706267; rs9838669; rs6794059; rs9853958; rs9714003; rs11926008; rs4974228; rs11917858; rs12492939; rs2365055; rs12715564; rs1716751; rs13314853; rs9866842; rs17670154; rs1868219; rs241684; rs9877106; rs2856008; rs7649524; rs9871584; rs9859800; rs1716736; rs11721114; rs13087353; rs7627230; rs4679552; rs13078972; rs12630519; rs17635515; rs1716711; rs6763084; rs9311789; rs12489480; rs9875827; rs7622334; rs2594150; rs1439007; rs1735472; rs1735473; rs17063746; rs9833913; rs11130814; rs11716669; rs3952441; rs12488010; rs6777641; rs1716725; rs241681; rs11927450; rs2856028; rs2594148; rs1947160; rs2594160; rs6763967; rs11130774; rs17634713; rs17063916; rs12107926; rs6799687; rs9758573; rs9817183; rs13079949; rs11720254; rs9850221; rs7610986; rs2682982; rs17633748; rs9836068; rs7374366; rs9849492; rs6785481; rs17064396; rs9812794; rs13087160; rs6777715; rs6767142; rs2156975; rs6802913; rs12632090; rs7619351; rs12497501; rs6446132; rs6766863; rs9850579; rs9876522; rs9311798; rs9820783; rs1447960; rs2594140; rs2736796; rs212016; rs1040337; rs212034; rs720285; rs1797563; rs213386; rs242209; rs2611414; rs213385; rs1523115; rs2734380; rs213408; rs1447981; rs213328; rs744192; rs2630206; rs994929; rs294457; rs2736784; rs931321; rs1569348; rs681119; rs675411; rs2687165; rs294459; rs591934; rs213388; rs242213; rs969562; rs1040335; rs639244; rs2736821; rs294461; rs172492; rs963685; rs1014595; rs1546817; rs213318; rs1666066; rs2736777; rs2367106; rs2049849; rs1472369; rs810525; rs1882898; rs1485734; rs212003; rs169913; rs1546830; rs1026989; rs213316; rs213309; rs687069; rs2630184; rs1353546; rs1352021; rs610766; rs400475; rs2630186; rs398322; rs183322; rs213336; rs809710; rs760322; rs213323; rs1569351; rs212066; rs736934; rs2121866; rs294453; rs802778; rs213400; rs213347; rs212051; rs612759; rs780366; rs2687163; rs390523; rs2121862; rs2630207; rs1385814; rs2132608; rs213322; rs1447974; rs2017941; rs2121865; rs294458; rs1874500; rs212023; rs2630173; rs810615; rs1357320; rs242171; rs445057; rs1474525; rs241693; rs212065; rs1496651; rs1353545; rs213384; rs984757; rs394509; rs212058; rs1947162; rs213342; rs1117870; rs213387; rs426569; rs624225; rs1882904; rs1569352; rs2736823; rs213306; rs49411; rs294454; rs492836; rs182418; rs213319; rs2687170; rs646372; rs1817587; rs1973780; rs2361341; rs2734361; rs213389; rs213394; rs1546831; rs2142301; rs1569349; rs780345; rs213401; rs780358; rs1485730; rs241706; rs760323; rs242197; rs1447976; rs2736764; rs923141; rs2121867; rs398105; rs1569354; rs2630172; rs732380; rs2687194; rs1057504; rs983946; rs2121863; rs2594250; rs51549; rs2361336; rs213392; rs750793; rs7634921; rs151749; rs2736760; rs1038516; rs741898; rs1882899; rs9835300; rs4679533; rs7634772; rs9311738; rs677703; rs2253211; rs2142302; rs11711026; rs12636057; rs9878446; rs6794056; rs2734389; rs9819920; rs9850852; rs242222; rs213398; rs6789538; rs385483; rs4566489; rs7615466; rs1022418; rs4468936; rs1496652; rs2687169; rs212040; rs4393860; rs11915344; rs6764575; rs452392; rs481165; rs213370; rs7624537; rs9810994; rs594063; rs3845973; rs6446122; rs609891; rs453951; rs2049848; rs13088111; rs9839662; rs993000; rs6773500; rs9854540; rs397227; rs17493; rs728519; rs9844365; rs212060; rs3732551; rs6787664; rs9284900; rs213315; rs6802584; rs7433793; rs213354; rs4679478; rs12487617; rs378022; rs3772475; rs684584; rs4679650; rs213418; rs212004; rs12636081; rs1569353; rs9815526; rs2173056; rs9311755; rs391844; rs7638558; rs2064017; rs722070; rs3843360; rs375127; rs7615052; rs212014; rs6764498; rs186153; rs9881736; rs1569355; rs6446117; rs534185; rs931317; rs1349019; rs294455; rs6784469; rs1485723; rs1496649; rs213308; rs6446102; rs6777599; rs4679526; rs12486718; rs2383; rs213373; rs2630181; rs11130754; rs169915; rs12633119; rs212009; rs9841239; rs1825630; rs9877486; rs6764256; rs685970; rs9846213; rs2197751; rs6764060; rs4638920; rs2687167; rs926143; rs213396; rs6800973; rs1569350; rs11130745; rs7635477; rs2736794; rs7618479; rs1385812; rs1385715; rs13314734; rs4679647; rs213348; rs802774; rs6781354; rs9837070; rs12638426; rs1882903; rs4679639; rs9881070; rs2293212; rs7631068; rs1947161; rs2687181; rs767000; rs2064019; rs7624360; rs983947; rs9311756; rs7644138; rs7621114; rs986651; rs430036; rs6446101; rs994930; rs7616694; rs212027; rs213352; rs7615959; rs6446097; rs2366964; rs11130752; rs1905866; rs1385716; rs7616955; rs6779494; rs809098; rs2611403; rs741753; rs7611775; rs6768883; rs7642268; rs1380466; rs212044; rs2049846; rs9829607; rs4679524; rs410351; rs9311749; rs9880343; rs213368; rs12494639; rs780362; rs6807027; rs4679511; rs640115; rs212064; rs7622441; rs9813457; rs13323989; rs2630149; rs213376; rs9856574; rs400747; rs780359; rs2171130; rs4679618; rs11707031; rs2736778; rs6807624; rs9848065; rs6797780; rs3907341; rs212015; rs294451; rs7619422; rs2734376; rs4679643; rs2885639; rs7647621; rs6786862; rs726692; rs7643828; rs13316872; rs9814467; rs213414; rs4413275; rs7641743; rs2361335; rs213395; rs575614; rs212032; rs7651340; rs11130746; rs9311746; rs4485674; rs212031; rs4295132; rs213366; rs11718208; rs368926; rs6771886; rs177139; rs2101339; rs2361340; rs7643604; rs6446089; rs7642167; rs3856668; rs9842521; rs6772047; rs7646666; rs9311758; rs7637894; rs12638728; rs802772; rs6799964; rs6764937; rs11717200; rs953480; rs212055; rs809097; rs6782631; rs4679476; rs780364; rs6801889; rs926140; rs6808467; rs242195; rs386348; rs212018; rs1496650; rs3772448; rs7626928; rs6808645; rs452203; rs6446129; rs6797046; rs3845970; rs1813201; rs11130751; rs2142300; rs13077692; rs10510839; rs213304; rs678981; rs11130756; rs3912493; rs9867642; rs2736783; rs12489534; rs7636619; rs4679520; rs1874501; rs1996829; rs6800393; rs3821487; rs213382; rs1447971; rs4679516; rs1057501; rs2687159; rs6780483; rs4679615; rs11130767; rs6768755; rs9874387; rs7621132; rs213407; rs2049847; rs727476; rs6446085; rs7627449; rs212061; rs6778218; rs3772476; rs2251216; rs242214; rs9851189; rs11720615; rs384530; rs212006; rs9311754; rs3772500; rs9826530; rs3915504; rs7651806; rs7627398; rs11130770; rs717821; rs2736766; rs3912494; rs7426703; rs213344; rs6797203; rs931322; rs11708562; rs10780042; rs7640460; rs12489018; rs2366968; rs430815; rs684753; rs186154; rs213299; rs1038517; rs741897; rs11926112; rs3845972; rs212063; rs1983535; rs3911035; rs7609578; rs6780146; rs6446104; rs6780613; rs213333; rs9311733; rs6786100; rs812964; rs241698; rs9829623; rs1390763; rs673870; rs6776575; rs4679545; rs177138; rs7645600; rs2142305; rs6777402; rs7649971; rs7625937; rs6446103; rs10510833; rs12152244; rs4679507; rs1006901; rs9871368; rs2629877; rs9682976; rs411076; rs6783802; rs2687168; rs6773849; rs4679651; rs780354; rs213320; rs9809480; rs9311741; rs4679648; rs12636197; rs1390765; rs7648865; rs6446090; rs7616124; rs2205361; rs213364; rs2736830; rs9817995; rs2630161; rs9311739; rs6775757; rs1597103; rs393593; rs2630182; rs213339; rs722071; rs12330869; rs212020; rs12492065; rs4679614; rs6768625; rs6781130; rs9825594; rs1967997; rs7626003; rs12638410; rs3772506; rs12632711; rs7623130; rs9817116; rs6788821; rs2736801; rs212048; rs969561; rs802780; rs12633077; rs936823; rs6783655; rs9813516; rs972795; rs3821480; rs7644852; rs6776005; rs10510845; rs212036; rs1485731; rs6763524; rs1447973; rs9839805; rs4679626; rs2736779; rs3915503; rs562516; rs3772482; rs2736812; rs1823242; rs2630183; rs241704; rs9853482; rs6802679; rs7629068; rs7626208; rs2366952; rs2736808; rs6807084; rs4234288; rs2736795; rs2630148; rs2734377; rs7643511; rs2220227; rs373730; rs6762886; rs151739; rs11721188; rs1872494; rs213411; rs7625787; rs9868281; rs9868156; rs7629400; rs1385815; rs11130753; rs378346; rs2064016; rs12487051; rs9816955; rs6795869; rs7610403; rs4679631; rs6762119; rs9814637; rs6446100; rs2885254; rs1485727; rs2166824; rs926141; rs6446130; rs615542; rs9311747; rs1996828; rs191927; rs49413; rs9865672; rs802771; rs6779529; rs9874888; rs7647196; rs10866034; rs7612797; rs9311748; rs6804909; rs2630165; rs6808129; rs802933; rs3732552; rs6773826; rs9830999; rs241701; rs3772445; rs4375999; rs12633138; rs4615035; rs7649040; rs1879996; rs7643424; rs1579912; rs9814351; rs9882907; rs213317; rs377319; rs440450; rs11130769; rs6801030; rs385245; rs12715550; rs741896; rs802777; rs2049845; rs9878437; rs995633; rs7615700; rs662910; rs381217; rs3845971; rs7640107; rs2736780; rs151743; rs9882944; rs10510847; rs3772505; rs1550925; rs13071758; rs213324; rs12636662; rs6804216; rs677264; rs996174; rs4083381; rs4679627; rs565226; rs9867241; rs6784012; rs9819258; rs2734363; rs9828226; rs3856669; rs734156; rs6766789; rs3772484; rs1079196; rs7613687; rs6769366; rs6795591; rs172454; rs2736765; rs143017; rs11711589; rs3856654; rs605545; rs11130741; rs7643042; rs10866033; rs582381; rs212043; rs2736825; rs3772447; rs9829514; rs212057; rs11718018; rs11920657; rs12637099; rs6795827; rs6446119; rs6778312; rs1485732; rs13061155; rs683809; rs9311745; rs13324247; rs6446096; rs17366680; rs9883016; rs212049; rs11711468; rs760316; rs13090091; rs2630143; rs9832192; rs7645258; rs17062179; rs2361337; rs6771732; rs4679640; rs659205; rs12490525; rs294463; rs9311750; rs9822030; rs17314469; rs2630174; rs17061792; rs7636374; rs9813806; rs12496632; rs633798; rs7630823; rs9822070; rs2736791; rs17063058; rs9835376; rs212062; rs9818696; rs12492267; rs12493170; rs17364716; rs10510826; rs10510834; rs650905; rs7623479; rs7627604; rs9879860; rs17061573; rs6793324; rs1006902; rs6808530; rs6446083; rs9863826; rs9868373; rs7611670; rs2629883; rs9881133; rs17254765; rs9809345; rs1447970; rs633189; rs9881653; rs550626; rs213423; rs17031569; rs11130747; rs17062796; rs17399247; rs2077587; rs2629884; rs6446125; rs17063425; rs7427130; rs11708661; rs11925321; rs17062101; rs13315808; rs10510842; rs521388; rs11706778; rs2630199; rs212011; rs11919455; rs12498050; rs9860090; rs12485388; rs6764230; rs17258256; rs10084745; rs212028; rs10510821; rs6810051; rs17063477; rs381450; rs13067835; rs3772468; rs213343; rs9823838; rs11924368; rs6792176; rs9828971; rs7619137; rs17061789; rs1683366; rs6806175; rs7637396; rs9852328; rs9869160; rs6766477; rs6789978; rs9985431; rs650215; rs9861525; rs7640017; rs810616; rs6791718; rs17061321; rs17395220; rs9827643; rs13088717; rs213295; rs6791450; rs12497400; rs6446127; rs3931996; rs11928100; rs1905865; rs6766262; rs3772487; rs11708751; rs10510836; rs11130736; rs521599; rs7625421; rs9879175; rs6797839; rs9851038; rs9877074; rs213351; rs17661314; rs241705; rs780360; rs6779755; rs1983536; rs12637950; rs6765826; rs11714243; rs9311762; rs12492234; rs3772501; rs2611410; rs12330253; rs9819930; rs7645058; rs12494319; rs6768598; rs6785232; rs7644970; rs9867348; rs17062609; rs12629710; rs17061180; rs9879807; rs212053; rs2362881; rs13075135; rs7647923; rs13064036; rs9874674; rs17336290; rs17062405; rs12495052; rs9861715; rs2736818; rs7653425; rs655011; rs17063156; rs9881669; rs11718994; rs17063427; rs6792440; rs9848465; rs623014; rs17061728; rs1882901; rs7615432; rs587959; rs510794; rs1683354; rs2736767; rs6804301; rs17062850; rs11715925; rs9820238; rs995467; rs17061763; rs9311767; rs11707595; rs9820066; rs9857010; rs7628950; rs6791049; rs13101027; rs6778206; rs6778121; rs7638267; rs17302837; rs12638665; rs965033; rs3772497; rs2630190; rs104795; rs13317306; rs17254574; rs9864403; rs12496532; rs2687189; rs9882551; rs17061708; rs4679628; rs12495450; rs643629; rs191926; rs213410; rs11924823; rs2611411; rs3772444; rs11707816; rs10490808; rs672802; rs212038; rs11917585; rs1349021; rs477697; rs6803131; rs3772464; rs4679630; rs11718957; rs932273; rs10510832; rs4432588; rs2687193; rs6789565; rs6797901; rs410072; rs9812269; rs7610652; rs12632865; rs6771240; rs412104; rs3772446; rs425036; rs11709255; rs12486972; rs17396765; rs6782148; rs9865813; rs670592; rs9831415; rs10510844; rs526773; rs9860107; rs11718430; rs213375; rs17061650; rs213381; rs9865210; rs13072228; rs13081934; rs17322850; rs2630166; rs9875624; rs6803449; rs2736816; rs4679530; rs2605432; rs10510831; rs12632178; rs6783454; rs2594264; rs2366953; rs9811336; rs13094437; rs17062824; rs6763641; rs17061182; rs9985430; rs17062524; rs3772498; rs9868731; rs3915502; rs2630170; rs9881224; rs6797938; rs1872495; rs11916155; rs17061844; rs2630203; rs9637471; rs3772483; rs17061377; rs17062497; rs9822178; rs17061346; rs7628314; rs6807405; rs7636129; rs11717164; rs6801817; rs6788677; rs688947; rs9311753; rs12497746; rs10510837; rs6783428; rs213325; rs12488124; rs492695; rs13066837; rs2734372; rs6806167; rs13070872; rs13434180; rs17061331; rs2630200; rs13098396; rs3821484; rs12634148; rs2736781; rs2630177; rs3856663; rs3772479; rs2088311; rs2629879; rs9825867; rs9837246; rs11928015; rs780368; rs652105; rs17296168; rs7652771; rs9877256; rs2205042; rs1882735; rs4679642; rs11715441; rs213391; rs10510829; rs12630887; rs1485717; rs3821477; rs9868048; rs10510841; rs9847570; rs12489929; rs13090962; rs6772201; rs606415; rs7622148; rs9841531; rs9823026; rs17062981; rs637820; rs9830224; rs17062882; rs11926935; rs7616522; rs17063416; rs242225; rs9681919; rs1683347; rs6772278; rs3856665; rs780348; rs10510822; rs17062963; rs11922239; rs3772508; rs9311736; rs7632050; rs17397398; rs17062799; rs17062892; rs143018; rs760317; rs12487096; rs9311737; rs2736826; rs17061897; rs17668453; rs4679527; rs6800257; rs213406; rs6789112; rs6446115; rs492234; rs11130739; rs9682987; rs9311744; rs620113; rs6782294; rs17061494; rs17061880; rs369161; rs2064020; rs604398; rs994928; rs11717293; rs17295070; rs12493207; rs13078190; rs885737; rs6446120; rs3772503; rs241700; rs9862380; rs6806748; rs169840; rs10510846; rs6800951; rs13058814; rs7631389; rs6775598; rs3912495; rs3772474; rs17362486; rs213307; rs9876685; rs17061388; rs9846621; rs9846216; rs12498046; rs9862811; rs9884086; rs213363; rs6789802; rs11924342; rs3890406; rs1666057; rs17299801; rs11922668; rs17062005; rs2049850; rs9820943; rs9853451; rs812445; rs1390766; rs17379746; rs6807277; rs13059195; rs6791776; rs17258872; rs213416; rs11707783; rs6776721; rs11923964; rs7633785; rs17361653; rs9847063; rs17338297; rs9842655; rs12485617; rs2262979; rs7653008; rs213359; rs2687177; rs383111; rs7641930; rs11924551; rs7433134; rs3821479; rs1666058; rs3772504; rs12715552; rs17062315; rs11716358; rs17062579; rs2594248; rs9834844; rs931318; rs9311751; rs1447980; rs12172960; rs6784057; rs17061328; rs11714913; rs2629882; rs590581; rs212017; rs9877140; rs7621056; rs213357; rs17061825; rs10510843; rs11714533; rs7641937; rs12492663; rs10510820; rs4142702; rs11715245; rs6765124; rs11711227; rs212033; rs974035; rs6446126; rs17325940; rs2630191; rs6446113; rs11917112; rs13063836; rs2736782; rs212042; rs13100448; rs3856659; rs11130763; rs6789642; rs9881093; rs17610429; rs9876544; rs2276732; rs734291; rs409484; rs11916801; rs606735; rs368553; rs213390; rs3772462; rs4679531; rs6766165; rs1995067; rs659193; rs7627733; rs1040336; rs4679544; rs17746541; rs6798840; rs9838143; rs10433635; rs6768733; rs11921348; rs17609699; rs2687161; rs1569347; rs369278; rs6784545; rs9826111; rs2630144; rs9863246; rs12486710; rs169841; rs2361338; rs2630180; rs17061847; rs213399; rs12629469; rs11916042; rs9834447; rs17062363; rs9814915; rs213371; rs1580457; rs11719244; rs9813494; rs2361339; rs17061683; rs6802153; rs17063335; rs6773600; rs802779; rs9875546; rs9877008; rs7642242; rs6768904; rs17062113; rs17062633; rs3856667; rs17257269; rs7653872; rs17253376; rs10510825; rs11708404; rs2736810; rs9810084; rs13090516; rs995468; rs11921834; rs213377; rs17361780; rs11916072; rs17302363; rs11921436; rs3772453; rs1350638; rs12493686; rs9855384; rs9824412; rs2630198; rs242192; rs212001; rs11130761; rs12488398; rs17061893; rs493783; rs6807325; rs17301211; rs632140; rs1882900; rs213412; rs7615522; rs12492175; rs9311752; rs585448; rs3772471; rs7349527; rs9883913; rs11920587; rs172456; rs760324; rs607730; rs11917125; rs17301008; rs17256369; rs9875209; rs7650052; rs6792218; rs9831397; rs9815054; rs2630154; rs7649422; rs12487545; rs9878583; rs411734; rs17658463; rs391770; rs1843399; rs294464; rs6764133; rs780361; rs2594239; rs9813549; rs1447972; rs780369; rs12635040; rs9821428; rs17395248; rs13064050; rs991783; rs3772467; rs12495662; rs4679477; rs6794055; rs9816428; rs4679541; rs9681598; rs9853628; rs4679542; rs10510835; rs2630187; rs11918446; rs7644699; rs9825541; rs9866142; rs9843313; rs9872356; rs212041; rs10490773; rs11917733; rs2734387; rs12487741; rs13074132; rs9817793; rs11706898; rs10510827; rs9855046; rs2253303; rs213300; rs4393861; rs4679523; rs7619114; rs3772502; rs9867457; rs17394135; rs7635514; rs9838518; rs17061239; rs9824750; rs213420; rs642214; rs10049216; rs433401; rs9827257; rs12638086; rs410552; rs13066381; rs4679606; rs242172; rs13092167; rs7634961; rs12489848; rs12486936; rs3772473; rs741751; rs7645607; rs3772489; rs2178929; rs11720966; rs623032; rs9868816; rs1016450; rs17314091; rs589522; rs659664; rs3845974; rs3772499; rs13314184; rs12374046; rs12638206; rs12636241; rs1084008; rs13100563; rs17379551; rs802775; rs213415; rs10510838; rs12487526; rs13098699; rs17061712; rs213326; rs602197; rs11130766; rs212039; rs6783772; rs408164; rs9821564; rs9833203; rs4679538; rs780370; rs9311726; rs6788803; rs6779785; rs981852; rs687342; rs9814473; rs9825234; rs6800049; rs10428174; rs10212340; rs4679521; rs1905863; rs471011; rs6446114; rs9876121; rs9881474; rs3772496; rs3845976; rs17295225; rs11715209; rs17256807; rs17062503; rs12633994; rs2734373; rs12635633; rs4468937; rs17062647; rs7615407; rs628404; rs212059; rs213353; rs2687182; rs3772454; rs11716199; rs11708236; rs6773303; rs9862817; rs9311742; rs17061176; rs2630194; rs1485733; rs12487204; rs3796193; rs2630202; rs2629880; rs17061478; rs434054; rs6789183; rs1597104; rs1349020; rs6446121; rs7635362; rs6446087; rs213297; rs1385713; rs9823903; rs2205038; rs2605434; rs213402; rs11706913; rs9311757; rs169914; rs17061982; rs4596100; rs2630168; rs13061510; rs9881795; rs9879616; rs9856634; rs11709440; rs9871183; rs17600182; rs11707726; rs13095141; rs9862176; rs212046; rs6762611; rs17375746; rs7614540; rs9844132; rs9681146; rs3772460; rs6779107; rs9818349; rs17599845; rs9849664; rs9827995; rs9860134; rs212050; rs7646323; rs675774; rs6794968; rs6800603; rs2611415; rs7645880; rs6446109; rs9852627; rs17255936; rs2736793; rs17339157; rs17374239; rs9827176; rs17062684; rs183330; rs17061746; rs597224; rs9862003; rs9870612; rs9849539; rs13096138; rs11921950; rs780712; rs12493494; rs17061173; rs780714; rs6769478; rs3901943; rs2734390; rs213346; rs2064018; rs12715549; rs809076; rs9848952; rs874239; rs9836899; rs6784140; rs9810520; rs6804914; rs7612646; rs3912492; rs2630201; rs505780; rs213383; rs17302202; rs616503; rs17062321; rs12490649; rs7615233; rs17323271; rs241688; rs4024131; rs6446128; rs2687158; rs4679610; rs9882623; rs736935; rs4679608; rs4145506; rs9837820; rs2687176; rs10510828; rs780365; rs6771484; rs2088310; rs780343; rs7623993; rs2367105; rs9824900; rs10510840; rs11926327; rs2630179; rs3772509; rs3856662; rs9841314; rs9878487; rs726693; rs7644933; rs6803403; rs9830740; rs12636019; rs6787076; rs1566056; rs7647491; rs17062116; rs9826272; rs2687899; rs12497472; rs293605; rs11719292; rs11717136; rs11711608; rs3821478; rs9856484; rs11715172; rs7641023; rs212052; rs9847855; rs9852001; rs9815786; rs10510823; rs6446099; rs213335; rs11924296; rs598678; rs9837060; rs3772507; rs213380; rs2605442; rs11707269; rs213356; rs953479; rs9813412; rs1948560; rs931320; rs1021227; rs6446123; rs17061923; rs741895; rs17376767; rs12493462; rs13087782; rs2064021; rs517644; rs4679475; rs6771504; rs213298; rs7637895; rs17374441; rs400620; rs780716; rs11915972; rs7634619; rs213302; rs17062557; rs3772485; rs12494512; rs17254231; rs1872531; rs6780176; rs13101214; rs2736819; rs13097687; rs213313; rs552676; rs1979076; rs17061246; rs423629; rs6771698; rs13067992; rs9832961; rs13070338; rs13434177; rs7648665; rs17062460; rs2446705; rs11130731; rs17365142; rs17374559; rs17600161; rs13063413; rs17296496; rs17063191; rs12490126; rs9855582; rs213311; rs2611408; rs760318; rs12496762; rs11130765; rs17061776; rs212007; rs393930; rs13098406; rs17061684; rs6797474; rs2594258; rs12492390; rs3856664; rs17398712; rs2228695; rs11130762; rs151747; rs7611309; rs17061248; rs1385710; rs17061368; rs17061932; rs213301; rs9809808; rs13086424; rs4679635; rs11925272; rs17366548; rs12632371; rs2605437; rs493345; rs1447975; rs6783730; rs242193; rs1352020; rs780372; rs241692; rs17301647; rs213358; rs1948562; rs780346; rs17061336; rs17063405; rs9845306; rs11720903; rs11923919; rs2461613; rs7650150; rs2734404; rs9829234; rs2121864; rs6797140; rs2086977; rs9870292; rs17062419; rs9872138; rs13434367; rs17062510; rs9875864; rs1038515; rs9879753; rs446714; rs7627676; rs12638815; rs3856658; rs7373797; rs9824566; rs9837647; rs6446110; rs12636523; rs13062399; rs3772466; rs9839495; rs17061231; rs9851805; rs2736803; rs2046455; rs11928686; rs6793429; rs6808425; rs2629894; rs151740; rs9851655; rs17062206; rs621666; rs615832; rs2630175; rs17063479; rs379394; rs17061517; rs9812704; rs2611401; rs2201649; rs6784936; rs11925432; rs213421; rs17062527; rs6803162; rs2630205; rs9819370; rs9853194; rs11130733; rs6806511; rs9877308; rs17063011; rs972794; rs294452; rs13069706; rs13325381; rs7648380; rs17063104; rs6781028; rs13081936; rs17296701; rs11916728; rs1683349; rs591947; rs3911036; rs2594246; rs212047; rs242174; rs7622382; rs17400084; rs7646022; rs2736786; rs13322304; rs2630167; rs9876417; rs9812396; rs6792115; rs17302746; rs6790477; rs12715551; rs12486471; rs3112498; rs555026; rs4679629; rs17061241; rs612947; rs400870; rs11130760; rs3772477; rs213365; rs6798364; rs11130748; rs213404; rs11920482; rs9311729; rs6776435; rs2594266; rs7615352; rs9826469; rs430270; rs17061744; rs7625054; rs413942; rs17062458; rs7636422; rs415832; rs13060068; rs7623184; rs7644553; rs9875448; rs9812343; rs584551; rs17061475; rs17063325; rs17254898; rs3772452; rs17061910; rs6786355; rs17061366; rs6779703; rs17062691; rs9873291; rs213369; rs17061540; rs9826315; rs9843907; rs675743; rs3772470; rs2736761; rs4234290; rs583363; rs4479546; rs12490629; rs6793471; rs17295332; rs1809540; rs17063126; rs7638091; rs926142; rs17062563; rs9842626; rs10470622; rs17061316; rs401810; rs9824783; rs6793646; rs13070475; rs213338; rs10154846; rs2630196; rs17062346; rs2630189; rs17061164; rs424675; rs2611409; rs17063428; rs17400197; rs4455289; rs17061197; rs17063024; rs1447968; rs17254065; rs9860649; rs1908771; rs17061250; rs10866035; rs13316416; rs17061895; rs9831509; rs17062148; rs17062372; rs7642732; rs212000; rs2103474; rs2629896; rs780344; rs17062361; rs1380467; rs9871450; rs11130742; rs11926030; rs17363039; rs11717219; rs17061342; rs9835058; rs7628063; rs17063090; rs7631677; rs2366965; rs11711525; rs9877688; rs3836268; rs9818726; rs7645950; rs9844074; rs242198; rs9826614; rs9846395; rs13316980; rs2736763; rs213349; rs17062003; rs17063095; rs2630147; rs2293211; rs13316171; rs4426638; rs7614564; rs7649027; rs6809984; rs1531334; rs13327150; rs2223086; rs213355; rs213341; rs4679518; rs4679609; rs4024129; rs6765570; rs17062553; rs526389; rs17061699; rs17062150; rs17062662; rs12633701; rs11715564; rs7615116; rs6787059; rs3821485; rs11708267; rs6779449; rs2736807; rs17062415; rs13319697; rs9833555; rs6776492; rs17061765; rs6807483; rs17031605; rs17668326; rs17063248; rs7639576; rs2734379; rs423336; rs2736792; rs17063200; rs4679529; rs17258709; rs17062578; rs9823129; rs4632501; rs17062603; rs17397822; rs7620217; rs294462; rs606168; rs241687; rs293604; rs669229; rs9851197; rs2594251; rs9849856; rs17063484; rs4679522; rs689497; rs1905864; rs541960; rs497767; rs17062506; rs212013; rs545783; rs12107407; rs11718220; rs17063443; rs7616359; rs9836506; rs9817691; rs12493585; rs213310; rs1843538; rs7648647; rs13070051; rs9820356; rs2605441; rs17061837; rs17031558; rs874238; rs17062353; rs242212; rs2629891; rs11715819; rs6446093; rs9818342; rs9839754; rs6792533; rs6763743; rs2734354; rs13064561; rs586011; rs12490626; rs2630164; rs293606; rs9879843; rs2605435; rs3772491; rs622875; rs1159236; rs17062454; rs7645438; rs242241; rs2687152; rs9818182; rs13318087; rs17062392; rs17061162; rs12635905; rs6781179; rs6773713; rs3845977; rs17606826; rs7610005; rs17319929; rs572459; rs12172945; rs13087386; rs7610087; rs6778142; rs4679625; rs411122; rs17061988; rs2171077; rs3772458; rs2630145; rs2121861; rs2362456; rs9863244; rs4679623; rs3856670; rs17061653; rs11130768; rs12638903; rs6446086; rs13314141; rs2687185; rs17061392; rs17257241; rs17061484; rs3856655; rs242196; rs17309998; rs9860752; rs11924684; rs780715; rs6774343; rs12637710; rs17365525; rs17061814; rs9860502; rs3821476; rs9867596; rs1040338; rs6776501; rs6790844; rs17061318; rs17061961; rs7634079; rs17061381; rs6777011; rs2734391; rs6792761; rs11130732; rs9874832; rs11712381; rs13060029; rs6767126; rs17061767; rs13099584; rs9847503; rs6782804; rs13075410; rs17061726; rs741752; rs213345; rs17765996; rs6782393; rs4679607; rs17062413; rs11927427; rs17061302; rs17609783; rs11929596; rs499323; rs13322587; rs17062284; rs17061186; rs2687895; rs9831022; rs2734383; rs17061689; rs11927585; rs10428177; rs17320834; rs3920478; rs242194; rs11925198; rs17061716; rs1485904; rs10154851; rs7373803; rs650197; rs13092173; rs17062953; rs17062786; rs17062707; rs17061373; rs9813727; rs12488248; rs7641720; rs2736817; rs17061428; rs10155027; rs1523116; rs2594268; rs1385811; rs9881665; rs12486187; rs675758; rs1683344; rs17063215; rs12633953; rs9870279; rs9851955; rs17063482; rs17063100; rs17063050; rs17062605; rs17375293; rs9815524; rs1948561; rs242201; rs10866032; rs213405; rs17062141; rs17325451; rs9809877; rs294460; rs4679505; rs17061335; rs2687150; rs12632643; rs11720196; rs9865027; rs7621164; rs4502542; rs211999; rs9833389; rs17062600; rs1374858; rs9817210; rs12639423; rs11713599; rs242226; rs212029; rs4679515; rs9855365; rs2736785; rs9867576; rs9856092; rs7629424; rs11719552; rs2594252; rs4679622; rs726409; rs563600; rs6806516; rs12495543; rs17062390; rs9311765; rs17061479; rs17061380; rs7653314; rs17062567; rs2630176; rs2046454; rs6784354; rs11715559; rs13095971; rs17061193; rs12629117; rs11920301; rs1970842; rs17061766; rs683908; rs213329; rs17061312; rs1564912; rs9834956; rs13096288; rs6776604; rs17320006; rs17609762; rs17061210; rs9882201; rs9813221; rs12152416; rs2736827; rs12630463; rs17061295; rs2629895; rs11720480; rs294450; rs7630255; rs212030; rs4289309; rs7622777; rs5014208; rs6784446; rs17062509; rs1843539; rs7646225; rs9855874; rs17607715; rs17658860; rs17061919; rs17062756; rs812444; rs11720431; rs17061408; rs9876422; rs13082004; rs12486873; rs12629886; rs6785656; rs17255191; rs11130734; rs17063018; rs9829333; rs7641907; rs9849125; rs6805528; rs1016449; rs17080828; rs6802579; rs17031575; rs4679637; rs213409; rs6783062; rs241665; rs9847443; rs17061812; rs10510830; rs9853625; rs415175; rs4679619; rs17063274; rs780347; rs17062344; rs213361; rs6772159; rs17063250; rs9829738; rs7643359; rs212008; rs12498126; rs7616500; rs17061326; rs3772450; rs6787894; rs12629851; rs780371; rs7626522; rs11130749; rs2734378; rs17061320; rs11928062; rs1022445; rs213327; rs7625055; rs17061338; rs1447962; rs9866689; rs971866; rs12497397; rs11916661; rs17061337; rs9880771; rs17062502; rs17063073; rs17255873; rs13084717; rs9871827; rs11717976; rs6806145; rs2736769; rs2178927; rs6771883; rs7628184; rs17817118; rs4605500; rs13088815; rs3772451; rs17324031; rs212025; rs9817092; rs2736787; rs4327338; rs4019443; rs17302126; rs13317933; rs17062272; rs17610098; rs2736824; rs9869016; rs9311730; rs6446111; rs2630178; rs17061232; rs6803318; rs6789121; rs13313901; rs17061269; rs11716313; rs9819455; rs575388; rs2687192; rs1845898; rs4608644; rs17254835; rs13072187; rs12486822; rs13324046; rs17301396; rs6446116; rs9311743; rs6791403; rs213294; rs6777815; rs2630204; rs9816712; rs17061678; rs213350; rs17301106; rs12635331; rs6777241; rs9813638; rs7643955; rs9858972; rs3112505; rs4679611; rs3112497; rs11130755; rs213374; rs2362889; rs2611404; rs7616806; rs17061972; rs2166790; rs9825127; rs3843359; rs626988; rs995466; rs151746; rs241695; rs9817027; rs17063438; rs9815796; rs17061181; rs17061385; rs9882078; rs2362888; rs9820451; rs7630991; rs17365190; rs2205041; rs17062519; rs9866478; rs2629899; rs4411839; rs12492524; rs10212612; rs11921963; rs17062191; rs7644751; rs17061398; rs12330860; rs9871341; rs9881466; rs9863289; rs17062269; rs13070349; rs13061158; rs12493500; rs17062513; rs9789989; rs7432036; rs7614251; rs11917122; rs7653300; rs1666064; rs517711; rs986015; rs17063317; rs11914464; rs1403200; rs242189; rs17062604; rs4284938; rs17062093; rs1352022; rs1456157; rs7646126; rs9863137; rs17061755; rs213340; rs9758551; rs4679617; rs7634622; rs9845099; rs478899; rs440692; rs4679508; rs13075738; rs7648572; rs9837503; rs1485725; rs9862666; rs17061546; rs17062890; rs2736762; rs17608587; rs4679512; rs7653213; rs9840704; rs12106924; rs213426; rs1485729; rs241694; rs12494015; rs212037; rs1629023; rs12635236; rs780935; rs17062350; rs17061780; rs213427; rs6805337; rs213337; rs2629889; rs17062324; rs2734375; rs473944; rs17062793; rs17062966; rs242224; rs9849524; rs1683356; rs4679479; rs17063275; rs17061900; rs17599894; rs167140; rs11710814; rs6795784; rs6765672; rs294456; rs213367; rs1380465; rs11130743; rs9883950; rs6776220; rs2736802; rs9861820; rs2687179; rs212045; rs17061705; rs11918355; rs17061444; rs9855768; rs9881503; rs9869623; rs12630613; rs9831755; rs7638084; rs6446092; rs34841206; rs11707548; rs2611417; rs17063396; rs492308; rs2611416; rs6806074; rs1564914; rs9876035; rs17061864; rs17061480; rs6767115; rs1038501; rs9834515; rs589792; rs633577; rs9311766; rs17061912; rs11921817; rs212019; rs9825503; rs6787176; rs2629875; rs11130764; rs2276733; rs9825153; rs4679624; rs17062367; rs2178930; rs10049212; rs213305; rs17063440; rs11708700; rs4679510; rs6786186; rs17063329; rs9829628; rs2734352; rs17061544; rs6765614; rs17062560; rs12638610; rs9863279; rs9819347; rs2687157; rs12163583; rs4124061; rs17061598; rs9876434; rs9873339; rs17063320; rs17062508; rs17061244; rs11720016; rs17300987; rs6780740; rs12107689; rs780367; rs212010; rs1385813; rs3772480; rs293603; rs241691; rs7642454; rs11922503; rs6804014; rs34600946; rs17296363; rs9829244; rs10470699; rs9837929; rs17063086; rs9822080; rs1485718; rs13319467; rs12638226; rs2629886; rs6802928; rs17050840; rs12629288; rs12629475; rs9828114; rs17299290; rs7636416; rs10470623; rs7646720; rs17606882; rs17062198; rs9816031; rs5012855; rs17061340; rs608582; rs4277641; rs9862819; rs9839118; rs125634; rs2362892; rs17062785; rs2200453; rs17362087; rs213424; rs17062611; rs689498; rs3821482; rs6801616; rs7636381; rs2605436; rs17061352; rs17061493; rs17609657; rs17658293; rs2629893; rs12633251; rs2736789; rs430766; rs9815985; rs11130750; rs439087; rs9828649; rs11922717; rs9862806; rs12495046; rs2687151; rs212054; rs17062360; rs17395576; rs7626013; rs7646420; rs4679641; rs7616048; rs17061253; rs2361333; rs17061322; rs9865682; rs12488566; rs9857624; rs12632676; rs13059601; rs7622557; rs2366966; rs970045; rs4679528; rs2736814; rs10222349; rs6446112; rs11917913; rs9883296; rs3772459; rs17599363; rs17062072; rs9838966; rs1996958; rs1628424; rs9866051; rs293602; rs9880846; rs9862543; rs12487811; rs1485724; rs35396167; rs2363674; rs28616691; rs28697197; rs35428632; rs1880215; rs34379697; rs10711092; rs9812744; rs35087705; rs10621998; rs11425388; rs7626047; rs35736825; rs36000584; rs11328354; rs1716731; rs34146546; rs6807024; rs10711853; rs7640222; rs7372992; rs13080876; rs180997; rs3037241; rs6764687; rs34955737; rs2594169; rs11324131; rs13074919; rs35267117; rs35545161; rs11359825; rs34626574; rs35710425; rs36022571; rs2682965; rs1584339; rs11420680; rs35093190; rs5029083; rs11276347; rs36071434; rs34674979; rs2364297; rs34462323; rs2594136; rs2682952; rs2856026; rs5849383; rs13091017; rs13077491; rs11329027; rs28797588; rs9683009; rs35626537; rs35583705; rs7633467; rs13073875; rs28393609; rs13098868; rs13096673; rs13315117; rs13076157; rs35763529; rs9856487; rs11468684; rs36054860; rs5849386; rs34365732; rs36121511; rs9875027; rs180988; rs34357389; rs35159710; rs180982; rs35356066; rs35640781; rs10534410; rs9883535; rs28548787; rs34703671; rs35164152; rs1716702; rs1898753; rs10698531; rs11283138; rs2682948; rs35026899; rs35599983; rs11915678; rs6446163; rs2856063; rs3074239; rs4688335; rs5849298; rs35367446; rs35422497; rs34649848; rs2682973; rs28420864; rs2121856; rs10461040; rs17063619; rs28581589; rs34166354; rs35388402; rs11712260; rs35601438; rs35005491; rs3060321; rs34226189; rs11357438; rs13073857; rs13075230; rs2859551; rs2856015; rs13065918; rs12054454; rs10576224; rs10694115; rs1974441; rs10575989; rs9871638; rs10669228; rs2121855; rs36045711; rs34766905; rs11130827; rs1735452; rs35513066; rs34436810; rs6446134; rs36058743; rs2156977; rs34706873; rs28448819; rs28550945; rs2594155; rs6787285; rs35166009; rs10703932; rs9637480; rs13081222; rs11712122; rs34276190; rs35463727; rs13064251; rs2040376; rs11456532; rs36150634; rs28670997; rs402064; rs35390919; rs13096823; rs34031319; rs34157668; rs36084042; rs5849393; rs9874497; rs12633777; rs2734347; rs11705843; rs35100604; rs9755753; rs34999446; rs2363672; rs9874571; rs11920919; rs13086168; rs13083532; rs36147560; rs11708561; rs34376484; rs35076933; rs36187720; rs34516655; rs34356910; rs9828263; rs13096211; rs34818699; rs1716728; rs1880217; rs6802917; rs151738; rs5849376; rs3074255; rs13069540; rs34877133; rs13074038; rs34391198; rs13100739; rs34800096; rs4688353; rs34628640; rs13316028; rs28411760; rs35171141; rs34207541; rs35871635; rs13063492; rs35871234; rs2856061; rs4974247; rs13078372; rs34944382; rs34196389; rs34108453; rs4435637; rs10621898; rs34744734; rs9844031; rs11927785; rs34870709; rs35499339; rs1965145; rs7643636; rs35150240; rs2734345; rs2226976; rs11337326; rs34551612; rs35582164; rs34271784; rs28551500; rs35012631; rs35311139; rs2682936; rs13090450; rs7609794; rs6782282; rs10704323; rs35565079; rs9990004; rs34986622; rs35245111; rs4688465; rs2218652; rs2040379; rs181005; rs9868595; rs13317696; rs9842782; rs34174974; rs34401538; rs9831418; rs33965820; rs34773072; rs35373770; rs11928502; rs13060732; rs34895617; rs9825246; rs2187634; rs6769291; rs11370683; rs13097091; rs2687154; rs180986; rs13081364; rs1735455; rs6806308; rs34700535; rs34070618; rs34673526; rs28783473; rs13083707; rs28418480; rs28448293; rs11344395; rs34686536; rs10707963; rs6775224; rs34478170; rs2594146; rs1735450; rs11272366; rs9878337; rs10568757; rs35343967; rs35359990; rs35787121; rs6801528; rs11425470; rs11915490; rs9990336; rs34287614; rs7649527; rs28884878; rs1716704; rs28491152; rs10576663; rs35911874; rs2856023; rs7629955; rs34252907; rs34739265; rs35788475; rs1823243; rs4020780; rs6773491; rs13086671; rs35863141; rs12492105; rs13070030; rs11720919; rs7625573; rs35858490; rs11472546; rs9813447; rs10653205; rs36128949; rs35501970; rs961997; rs13314035; rs2365486; rs2364294; rs9877613; rs9837041; rs35643303; rs35434242; rs13101168; rs35136364; rs34064157; rs36179040; rs180979; rs35008199; rs34162767; rs721206; rs13091994; rs10212384; rs12487887; rs10706478; rs35156110; rs13066650; rs1524017; rs12491230; rs11427587; rs35381011; rs35636925; rs2594131; rs11707631; rs2860193; rs28508111; rs35016129; rs569112; rs34022190; rs34897753; rs34099300; rs10626854; rs13067953; rs28658327; rs9819526; rs4129351; rs2682957; rs9829848; rs34824573; rs34335317; rs36180064; rs5849400; rs4474995; rs2856053; rs3037209; rs34348154; rs34903967; rs2682975; rs13072770; rs7433409; rs7649297; rs17063581; rs10533881; rs11401294; rs6775312; rs11425154; rs34515346; rs17063488; rs9858465; rs10704615; rs35873528; rs9812327; rs4688358; rs171352; rs9877087; rs34916589; rs11718094; rs34749460; rs9681765; rs9837018; rs9873789; rs34115573; rs35617200; rs34709345; rs6445199; rs2856051; rs35551227; rs6802461; rs241668; rs13065516; rs35908550; rs2855999; rs34811988; rs35386733; rs9820875; rs9850790; rs10621306; rs7431478; rs1839076; rs7372733; rs2856079; rs11715419; rs28478282; rs35883178; rs4688333; rs4020380; rs34418330; rs34956027; rs9833340; rs34525181; rs6780422; rs28525348; rs34032172; rs35502892; rs34559466; rs5012715; rs4688507; rs2856009; rs1735463; rs36004430; rs2856050; rs10704764; rs11130824; rs11925681; rs34455205; rs7617339; rs34572867; rs2682983; rs4021312; rs9835422; rs1055673; rs35250637; rs9826449; rs35348354; rs2105830; rs28816764; rs35919545; rs11282211; rs5849372; rs12054388; rs181007; rs28576434; rs34516750; rs13060811; rs2856073; rs1735442; rs35029951; rs4974242; rs4479544; rs2682934; rs11280805; rs2165043; rs2156976; rs10641935; rs10664594; rs11445450; rs13100037; rs180990; rs2226974; rs34618598; rs35744933; rs35401166; rs4599253; rs5849374; rs9829538; rs181000; rs34933857; rs34412023; rs9817744; rs34983593; rs9852481; rs28584187; rs1716716; rs34431077; rs13065530; rs9834789; rs2594235; rs6769615; rs36069838; rs4561778; rs7626938; rs34363503; rs9864174; rs7609788; rs241679; rs11355861; rs4688297; rs2594133; rs7641879; rs17063583; rs35834727; rs28748014; rs5849296; rs11359494; rs35873241; rs35487435; rs10575654; rs9836264; rs2856000; rs34401856; rs2118810; rs4974252; rs242188; rs11387609; rs10686970; rs28755000; rs17063650; rs13080777; rs4688338; rs35734369; rs11391400; rs12629280; rs13084385; rs9869679; rs9871663; rs28430306; rs34746589; rs4688354; rs2156971; rs4605538; rs2594241; rs12631103; rs34920274; rs4679551; rs9868796; rs10576295; rs7634630; rs34539792; rs35948190; rs13323714; rs28735912; rs5849405; rs34936297; rs34942224; rs35773630; rs7651656; rs34591582; rs28885672; rs1794073; rs13079703; rs34600947; rs9841737; rs11405504; rs4542972; rs11438531; rs36136303; rs28750168; rs180985; rs10619770; rs11710155; rs36022063; rs2885866; rs35689847; rs241666; rs10702654; rs28575473; rs1623711; rs35974843; rs13088864; rs5849379; rs11716189; rs34805544; rs35239751; rs9872213; rs34236976; rs10689165; rs6768510; rs2363671; rs10695073; rs1716750; rs34229498; rs11430868; rs34283247; rs6795921; rs4688469; rs28537075; rs9870929; rs9811948; rs28496326; rs35007610; rs35892825; rs10691156; rs11716726; rs2734362; rs35145550; rs3046744; rs11434661; rs11916130; rs2205354; rs11303821; rs11928556; rs12488246; rs36001340; rs9875360; rs34066354; rs35704934; rs11712204; rs35403191; rs9837499; rs35411656; rs7632898; rs2734364; rs1735451; rs10656054; rs5849398; rs2734349; rs6801067; rs9869618; rs34725164; rs28605691; rs765434; rs35675677; rs35681055; rs13086029; rs1716707; rs10670228; rs10663822; rs13319932; rs13087179; rs242185; rs34684512; rs13087014; rs9819916; rs35250444; rs35746862; rs17063529; rs34341542; rs6762023; rs7651928; rs10622214; rs6773927; rs2734412; rs34962341; rs35912845; rs13096705; rs5849377; rs34430551; rs28728310; rs34320797; rs35699949; rs1583702; rs9849983; rs727346; rs35696878; rs10703194; rs2594117; rs9810266; rs11425787; rs7618698; rs149288; rs2363682; rs35789205; rs34412484; rs2856035; rs11382712; rs13060457; rs34225061; rs34640191; rs34673542; rs11392485; rs34957475; rs35183529; rs35766255; rs28753768; rs2682938; rs10533880; rs13069537; rs10695129; rs979312; rs12632616; rs11348608; rs6766427; rs34832921; rs180981; rs35149801; rs9821492; rs36013056; rs10562060; rs10625111; rs2363676; rs34654439; rs9647383; rs13066763; rs2856007; rs34822388; rs36052683; rs34495897; rs2856078; rs1716712; rs34292145; rs34485211; rs35960525; rs13091058; rs3832204; rs35204675; rs10662568; rs11278628; rs2856013; rs35432601; rs2594120; rs34951126; rs2856049; rs13321408; rs35072941; rs3037275; rs6804992; rs12491542; rs181004; rs2205346; rs11462420; rs36063715; rs9828871; rs9856646; rs34723569; rs5849399; rs34396410; rs13066447; rs2859662; rs6766677; rs11293623; rs35245268; rs11365015; rs11328245; rs36117889; rs9820481; rs35254240; rs2856011; rs2250969; rs35650409; rs34552943; rs6777603; rs2856066; rs9874852; rs34620163; rs7617938; rs5849407; rs12632475; rs6782381; rs13090237; rs35799828; rs12639089; rs35064699; rs11714964; rs2594127; rs35631111; rs1569345; rs13315448; rs35303160; rs2364298; rs11708181; rs28649296; rs11439512; rs9829239; rs34095991; rs4688134; rs4501070; rs34590329; rs13323559; rs34483377; rs2736757; rs9830059; rs35348304; rs35927692; rs34446077; rs4131084; rs35173173; rs34399107; rs9830759; rs13086837; rs9713179; rs9830615; rs11706083; rs13323578; rs2856016; rs36081877; rs6793716; rs35800632; rs9851716; rs12629536; rs241680; rs1735474; rs36092451; rs34944499; rs35407960; rs13086900; rs13318799; rs28867979; rs1735446; rs34747779; rs4688292; rs7429202; rs2097245; rs33996943; rs9815870; rs35059482; rs35280964; rs1735465; rs35582986; rs28856691; rs2856019; rs34439911; rs11439537; rs10664035; rs35555910; rs4688194; rs12330455; rs6791869; rs28738855; rs12488069; rs34367227; rs34938634; rs11293951; rs4688379; rs2856020; rs34296525; rs1821944; rs34170228; rs6783289; rs34923529; rs9843764; rs35073498; rs6786603; rs35559858; rs34758574; rs35899453; rs13077540; rs9861349; rs2121854; rs34494286; rs17063907; rs11714472; rs11130828; rs2856054; rs35657114; rs35105245; rs13319364; rs5849392; rs34450737; rs34980096; rs13326349; rs10662562; rs4266142; rs2156970; rs12491643; rs10621225; rs33937609; rs34103921; rs17063575; rs13068391; rs1716746; rs35995776; rs4472047; rs10574931; rs9809726; rs5849406; rs13321403; rs1524018; rs28555532; rs35002792; rs34629540; rs34490290; rs181006; rs9825775; rs28868951; rs10546180; rs34055249; rs35694637; rs17031631; rs13322395; rs181009; rs11130786; rs5849375; rs2363673; rs28830835; rs17063926; rs35183064; rs10707795; rs34385578; rs28873069; rs13086117; rs11344435; rs35426147; rs7614509; rs11336775; rs2594168; rs6802143; rs34818520; rs34911543; rs34979014; rs1540264; rs1965144; rs36196206; rs28583267; rs7648601; rs241676; rs2594259; rs9869632; rs34972944; rs741890; rs11710325; rs2856069; rs6762101; rs1130978; rs36105469; rs35035467; rs5029084; rs35505617; rs28666776; rs7622067; rs34827609; rs6793331; rs2142297; rs35650631; rs6794099; rs36021215; rs35869445; rs7433194; rs34345610; rs34891541; rs180989; rs34782322; rs36152415; rs34095404; rs35363602; rs9815205; rs13087718; rs36086848; rs10621855; rs151744; rs2056834; rs6801372; rs28482301; rs2856046; rs10656019; rs35509555; rs36059042; rs34218648; rs34306015; rs2682953; rs6414611; rs28560409; rs6446177; rs2083266; rs28506184; rs11446370; rs9814803; rs2856064; rs13073765; rs11714170; rs34982675; rs35545949; rs28707531; rs2682941; rs35221092; rs35828098; rs35312000; rs10703190; rs9870453; rs35455823; rs13094274; rs9853325; rs2365487; rs2594255; rs2682972; rs34451030; rs10653206; rs11716097; rs9850949; rs1823244; rs11438506; rs11387424; rs6794021; rs13099255; rs11317231; rs5849385; rs4974238; rs9820935; rs9869626; rs1125285; rs12330305; rs2856052; rs13098867; rs35000370; rs17689244; rs13327793; rs35916380; rs28715912; rs11425572; rs1630653; rs2594128; rs13096643; rs1716754; rs2364296; rs2364299; rs35570778; rs36077598; rs9845813; rs35009509; rs6804386; rs4688336; rs13073732; rs1319373; rs2736735; rs34706798; rs35935535; rs13075178; rs7429700; rs13068091; rs35626086; rs13073213; rs12490432; rs12489327; rs2682958; rs28449422; rs2165042; rs11717185; rs9813137; rs34614721; rs1794074; rs5849395; rs34126057; rs9815486; rs34153115; rs35195170; rs5849394; rs5849408; rs11130832; rs6762109; rs7432473; rs10577229; rs34615883; rs6772343; rs34268864; rs34327357; rs6795548; rs5849380; rs34918994; rs35581450; rs5849401; rs35398590; rs10662932; rs34958501; rs9754560; rs4991694; rs13080382; rs6770111; rs28626240; rs13067776; rs7622829; rs4688359; rs9851860; rs1716727; rs34696094; rs2856024; rs11717364; rs34708949; rs4508731; rs180996; rs2682935; rs10575380; rs7651882; rs6773042; rs34260769; rs34427728; rs34909377; rs7356048; rs1716715; rs7620934; rs7651100; rs4596101; rs17063570; rs9833598; rs11351593; rs9823985; rs2856062; rs7431422; rs34005146; rs34647274; rs35971675; rs36191215; rs34954847; rs28705379; rs9854994; rs10577548; rs35786965; rs2056565; rs2682964; rs35708329; rs35713747; rs35035484; rs35950756; rs35979959; rs6779695; rs35683398; rs9827429; rs3952592; rs13068405; rs9809084; rs2855997; rs35666586; rs35256219; rs10588513; rs11370343; rs9849480; rs11359451; rs181008; rs1716703; rs2856060; rs13068446; rs36143644; rs11130808; rs34537487; rs35281998; rs35808939; rs12629072; rs9990003; rs34909493; rs11297542; rs34416041; rs11430739; rs34066804; rs2682955; rs28414779; rs13060497; rs2594124; rs5849373; rs28702371; rs35722852; rs34665072; rs36197522; rs180978; rs35247212; rs11396147; rs2594115; rs33987194; rs10702598; rs9853572; rs34100153; rs28726379; rs28367502; rs9873803; rs13098545; rs7638374; rs2856031; rs35809328; rs35558909; rs35937942; rs10596787; rs35438702; rs1272210; rs6446137; rs6793381; rs2886247; rs11130778; rs34057836; rs12635701; rs765271; rs2118814; rs9876426; rs35320264; rs36176490; rs9868561; rs34371463; rs1371092; rs34287266; rs3046704; rs6782546; rs35795196; rs4021313; rs35443634; rs6764919; rs35357854; rs4688355; rs33915401; rs4290800; rs35254708; rs13099227; rs2594263; rs11318342; rs34320086; rs11714429; rs10620746; rs180984; rs28790402; rs34316880; rs34918702; rs11337159; rs2856012; rs35595048; rs10576845; rs35198002; rs34779032; rs7638316; rs13088848; rs13074216; rs1735456; rs34606948; rs4679550; rs11456762; rs2856001; rs28472466; rs2594118; rs35013109; rs11281807; rs10706485; rs36033536; rs34430584; rs2594256; rs35938215; rs12487490; rs35059096; rs36140477; rs9862956; rs35047197; rs12492454; rs12494251; rs35534615; rs10562335; rs35585287; rs34163614; rs34696953; rs13323742; rs2594126; rs241667; rs9833028; rs4605537; rs34259904; rs35424414; rs6780451; rs9838956; rs1156587; rs5849402; rs13073737; rs34657304; rs2682959; rs35814395; rs11341318; rs180991; rs34255725; rs4501071; rs2856074; rs13073974; rs34294936; rs9864593; rs35858922; rs2226975; rs2682939; rs4974237; rs9814914; rs35308129; rs13327442; rs35910658; rs5012716; rs4378928; rs34363177; rs2856010; rs9808941; rs36184836; rs11434662; rs5849397; rs9842786; rs2097246; rs34609167; rs35037932; rs13326903; rs34821431; rs2734348; rs35121432; rs34393705; rs4991695; rs9755626; rs35010280; rs9826292; rs11379500; rs34253135; rs9839366; rs11278323; rs34110394; rs11918956; rs35294523; rs35530282; rs3037240; rs34943127; rs34565354; rs13087175; rs4688334; rs3037212; rs35637630; rs34683848; rs35361297; rs34501669; rs34515056; rs35784749; rs2099668; rs28703924; rs28766341; rs35169228; rs35299226; rs36213301; rs10711619; rs5849404; rs7640548; rs34929328; rs13094360; rs9866819; rs2859794; rs35269423; rs2682933; rs34470378; rs34201817; rs28680515; rs10616921; rs10620327; rs9839960; rs28660311; rs34914862; rs33939225; rs35479217; rs35166731; rs35242657; rs35093010; rs35481618; rs11414933; rs1447913; rs1554600; rs5849390; rs34731310; rs28856934; rs11456269; rs1735447; rs17063530; rs10620887; rs6770159; rs13096774; rs2682947; rs2226973; rs4458366; rs12632940; rs2859663; rs11130787; rs17031623; rs10586440; rs1735459; rs28845848; rs2856070; rs11279188; rs28768455; rs34338152; rs9836556; rs11711795; rs9790016; rs34116159; rs6797158; rs5849297; rs2363668; rs35353442; rs11297153; rs180980; rs9833603; rs2856014; rs9873238; rs28604875; rs17063930; rs9871498; rs34511828; rs13091033; rs35222818; rs2251572; rs11342311; rs35110807; rs2156972; rs13100732; rs12632429; rs2859552; rs34220367; rs13323863; rs35478265; rs2142299; rs4524236; rs13076525; rs13082796; rs36036534; rs28678424; rs13091132; rs2594116; rs9654008; rs2187635; rs9754679; rs34136528; rs35115252; rs2594121; rs11391685; rs9882869; rs9830971; rs6786356; rs34247297; rs10530745; rs7356063; rs35802292; rs35408658; rs2856065; rs3074256; rs36089312; rs2363675; rs9822578; rs28590688; rs35313207; rs11921965; rs11710373; rs11446362; rs10617295; rs28708759; rs34243612; rs10653812; rs35675876; rs4292193; rs35881955; rs35082108; rs10707340; rs13076939; rs13083049; rs34111196; rs35599254; rs9869553; rs9834653; rs34473180; rs4519689; rs2166813; rs13084713; rs7646798; rs35033038; rs35673396; rs13060670; rs11391529; rs28459374; rs9883990; rs2736751; rs10637926; rs6774890; rs9870642; rs1447915; rs241696; rs5849389; rs35527583; rs35527648; rs241678; rs35436653; rs5849391; rs28819530; rs11130829; rs13096718; rs9869204; rs34126858; rs35161045; rs13061677; rs13084163; rs35731128; rs11459342; rs11283815; rs10622213; rs11426035; rs4688207; rs3054020; rs11710413; rs3037236; rs2734346; rs34895944; rs2734411; rs6806749; rs11358547; rs2856022; rs1716708; rs9827853; rs34970155; rs35166973; rs9868836; rs11369125; rs9810275; rs35217802; rs34790838; rs9837071; rs2682937; rs1371094; rs34802371; rs35941471; rs1735441; rs5849382; rs12107612; rs13060737; rs6777395; rs11923398; rs12493853; rs35557543; rs34423892; rs11328983; rs35270643; rs11378635; rs7433800; rs11711494; rs5849384; rs35513480; rs35140567; rs1597100; rs35454787; rs35093806; rs34374881; rs35353184; rs5849378; rs13096315; rs28818630; rs12639018; rs6784990; rs35388697; rs2682932; rs2205355; rs107342; rs1267318; rs35129876; rs35300348; rs35451480; rs35996920; rs2682940; rs4688337; rs35825854; rs36064104; rs12637231; rs34327253; rs34499190; rs13098952; rs2856075; rs13083701; rs33999627; rs9819332; rs13316031; rs694338; rs34967661; rs680467; rs9809946; rs36012115; rs28762764; rs34879293; rs520737; rs10709109; rs151745; rs909110; rs635904; rs7624854; rs212022; rs34373315; rs190892; rs34579384; rs10222574; rs598508; rs35066861; rs35912433; rs36175120; rs28373656; rs13079397; rs34197269; rs9682326; rs35207762; rs192667; rs28538294; rs13095634; rs6764821; rs2736828; rs1474308; rs11400200; rs35231588; rs34005341; rs9829898; rs35397730; rs2629892; rs11313024; rs36014753; rs427263; rs1485715; rs2362236; rs11392233; rs5849314; rs34560933; rs5849355; rs10702893; rs13088666; rs10621041; rs2630169; rs13088034; rs11456216; rs13088055; rs35693946; rs33978427; rs36023952; rs17062655; rs2687187; rs35692822; rs35297861; rs9869351; rs34140915; rs6803420; rs9851823; rs13084152; rs35830544; rs11437244; rs2178928; rs12172955; rs35082528; rs9844975; rs34244389; rs598164; rs11401440; rs34108188; rs5849335; rs2594247; rs10678623; rs2687174; rs10622117; rs1385818; rs6772276; rs9851678; rs10662862; rs34867216; rs2736774; rs1825632; rs4019407; rs9856764; rs4020068; rs2594267; rs2629901; rs931319; rs34420724; rs33979600; rs35924713; rs695074; rs34529886; rs28563777; rs35569650; rs9829103; rs13094765; rs28552937; rs5849367; rs10648497; rs680884; rs9968157; rs11337847; rs2630155; rs6765281; rs241703; rs5849329; rs5849364; rs11414516; rs35603990; rs35010131; rs4257500; rs550271; rs28680683; rs4679649; rs35866265; rs1683642; rs658563; rs36206456; rs10599323; rs34629260; rs1630608; rs35658638; rs35282656; rs502074; rs3047601; rs13316266; rs4679543; rs34684433; rs34388117; rs35734112; rs12630039; rs6773712; rs2630208; rs11353060; rs28472615; rs644301; rs2594240; rs2223087; rs4679514; rs2629881; rs2142304; rs2166791; rs34420878; rs570987; rs398084; rs11435467; rs994931; rs5849309; rs936822; rs6801035; rs11456924; rs11307941; rs13321394; rs17340442; rs7432575; rs34059157; rs6771497; rs11294820; rs17062681; rs11304366; rs35907783; rs9812818; rs558799; rs35068382; rs643121; rs511829; rs34077326; rs33926480; rs1817615; rs11394238; rs34808738; rs35607317; rs11408566; rs2630197; rs2629878; rs4083119; rs11339957; rs802773; rs11369122; rs11459796; rs515208; rs13095234; rs10612042; rs6763702; rs13070067; rs34836199; rs655196; rs242215; rs599423; rs11292700; rs11291510; rs4679506; rs13092827; rs10702128; rs34543324; rs13091891; rs1485903; rs1719827; rs6802911; rs7641733; rs34335070; rs623612; rs34152522; rs10154943; rs3856661; rs242229; rs17062548; rs651665; rs6791382; rs34217736; rs600427; rs34276482; rs34267930; rs13095796; rs11298082; rs34606853; rs2734407; rs11401556; rs10702694; rs35536041; rs11452248; rs10716077; rs660097; rs11357385; rs11391965; rs1319341; rs9867252; rs35057861; rs34190482; rs570366; rs34087679; rs242190; rs34118312; rs35755790; rs3060314; rs674930; rs190891; rs2630160; rs34284077; rs11712298; rs28579930; rs34476489; rs655222; rs34748094; rs3112504; rs7636540; rs13085067; rs35746727; rs17062213; rs35509233; rs6762036; rs28735681; rs383180; rs35823785; rs35781602; rs41397044; rs9852879; rs34819971; rs36022402; rs970883; rs11302357; rs34984537; rs36145405; rs2687166; rs35174234; rs11300360; rs2687173; rs4441611; rs28387016; rs212056; rs13060660; rs560357; rs6769523; rs2611402; rs10540921; rs35153236; rs35959468; rs629627; rs9872805; rs2197750; rs13092798; rs35304624; rs2687901; rs391000; rs35840730; rs7612775; rs212026; rs10576463; rs35992738; rs2687188; rs9874226; rs35289739; rs2594234; rs13099360; rs13093788; rs5849328; rs6791176; rs34574670; rs17062607; rs17062298; rs13088637; rs9834305; rs7636133; rs35543838; rs41460748; rs34429390; rs11130758; rs35402912; rs2630151; rs11296303; rs475675; rs242210; rs34221661; rs35803418; rs3894422; rs10621942; rs34459199; rs34351487; rs34107042; rs604791; rs10576674; rs2605446; rs11457865; rs33935811; rs172455; rs12635180; rs1057503; rs11441945; rs34590310; rs34532632; rs35825158; rs11294007; rs588866; rs35651687; rs7622342; rs2687156; rs1964583; rs34531974; rs35240844; rs35714610; rs494368; rs13327466; rs802776; rs17298728; rs2450224; rs6798836; rs7610776; rs2630158; rs33937348; rs9857422; rs5849361; rs11299448; rs2687898; rs12633772; rs400030; rs10621786; rs570672; rs10620271; rs3894423; rs11420708; rs35015506; rs9846004; rs5849359; rs41505547; rs3836263; rs529626; rs35618987; rs35668749; rs5849339; rs13077273; rs34333733; rs9843458; rs442760; rs11385769; rs2611407; rs35245215; rs35428356; rs13092800; rs5849303; rs213331; rs5849305; rs5849344; rs34577004; rs34290422; rs9880785; rs1126268; rs11308405; rs10672242; rs2629888; rs17256383; rs35826777; rs34377485; rs10556979; rs9809679; rs35165735; rs28699278; rs35565582; rs10575548; rs17362276; rs10621464; rs2594237; rs34476175; rs34769124; rs9836175; rs213425; rs6789228; rs35034017; rs35438812; rs414751; rs1474524; rs4124060; rs34902177; rs17376950; rs34892552; rs35957311; rs11375265; rs439531; rs2629885; rs9814126; rs34919399; rs12492752; rs35546407; rs213334; rs901166; rs12163553; rs4679632; rs35294469; rs36031158; rs35370996; rs34436887; rs213417; rs213296; rs10553757; rs440337; rs7650713; rs13067663; rs28532353; rs5849319; rs36087881; rs10702961; rs35230709; rs34939144; rs7638538; rs28590559; rs35022605; rs6803991; rs35700900; rs167160; rs2611418; rs34922025; rs13068840; rs1683637; rs2885637; rs4446177; rs11299074; rs12106838; rs3100804; rs10716252; rs34559994; rs550237; rs3060310; rs1817616; rs11388787; rs10585061; rs17061245; rs34503855; rs5849311; rs35288900; rs2734382; rs2630171; rs34068812; rs11714457; rs34970137; rs213314; rs28716988; rs1683635; rs41384746; rs34816043; rs35688444; rs5849352; rs409432; rs671920; rs11369368; rs35303895; rs1038500; rs35443610; rs2736809; rs2630193; rs34668808; rs35773776; rs9878244; rs28610194; rs11293631; rs4021919; rs4021920; rs5849370; rs34184253; rs6147838; rs2736799; rs9876439; rs11436091; rs35417374; rs2472012; rs242220; rs34262673; rs34837102; rs35033374; rs11349315; rs34196742; rs9809756; rs615501; rs213362; rs10662742; rs510015; rs13065824; rs35019677; rs34059017; rs34113926; rs11425921; rs728518; rs2687190; rs558732; rs35928440; rs34956621; rs13085634; rs7630676; rs34862516; rs11918011; rs13321569; rs12053887; rs11359834; rs2630192; rs2629900; rs35292125; rs6446158; rs9858300; rs17062653; rs35909447; rs695144; rs5015378; rs11708941; rs34137642; rs34400019; rs1983425; rs2736813; rs1666065; rs525709; rs2734353; rs2736775; rs2594238; rs28490895; rs11331230; rs34440332; rs34775476; rs13088669; rs34272009; rs3112501; rs36123588; rs35975975; rs9865860; rs5742127; rs9832932; rs35666962; rs1628506; rs33954362; rs2734410; rs936821; rs34893282; rs2220240; rs35745922; rs10637442; rs2450225; rs4679636; rs34032310; rs2064015; rs901164; rs2450227; rs10662718; rs35898751; rs650697; rs11720828; rs10702573; rs4024132; rs35067946; rs5849315; rs2687164; rs34420035; rs35867997; rs34538996; rs378177; rs34336496; rs36019591; rs167159; rs242228; rs3052772; rs35122656; rs608341; rs4022385; rs34180760; rs1318329; rs34877048; rs4679540; rs10646479; rs3112503; rs35724062; rs11360780; rs34995397; rs406364; rs34732137; rs34673563; rs6790458; rs242219; rs11328401; rs12635117; rs35605213; rs1485726; rs592763; rs17062490; rs13313997; rs3891656; rs2362883; rs17322285; rs35717946; rs1485716; rs12107679; rs404404; rs10680391; rs34974981; rs5849354; rs17061422; rs1683348; rs34970290; rs11313847; rs1111567; rs35283824; rs1485722; rs10619871; rs2605440; rs394261; rs2736822; rs11433582; rs11391601; rs9831468; rs2687186; rs6785349; rs242191; rs6446124; rs13096724; rs9857445; rs36067393; rs1825631; rs35007946; rs10702693; rs35601814; rs2366962; rs654791; rs34307116; rs34886888; rs11360937; rs3856660; rs10716376; rs35209666; rs41276483; rs2101322; rs13069875; rs623645; rs2472009; rs41358048; rs663274; rs9829427; rs34797911; rs3856657; rs3100801; rs2736768; rs9819123; rs11368905; rs2687172; rs10527581; rs10633871; rs5849347; rs41532848; rs34615685; rs615275; rs666445; rs5849343; rs35531886; rs9881435; rs34318256; rs35933553; rs5849340; rs34783282; rs11288782; rs10718005; rs34136457; rs620783; rs13076427; rs6765946; rs1613046; rs410775; rs11298083; rs13093024; rs13081317; rs11345934; rs666083; rs34595821; rs9879525; rs35739707; rs644087; rs34966988; rs11293550; rs11456344; rs151748; rs13095523; rs35739482; rs11418936; rs447643; rs11280475; rs34479858; rs6762271; rs213413; rs5849351; rs9824749; rs35830310; rs4395357; rs35366562; rs17061294; rs3772449; rs17062091; rs17062818; rs10663373; rs11715784; rs28451006; rs36117888; rs693495; rs441410; rs13087174; rs6787887; rs34596023; rs34361915; rs28538229; rs9682843; rs5849368; rs10709070; rs34917954; rs10597353; rs34858537; rs7647647; rs3836262; rs28566813; rs583560; rs3047602; rs28511287; rs3047575; rs11304071; rs35278876; rs34412225; rs9823629; rs11422969; rs34390680; rs9864038; rs2734388; rs34692050; rs7649319; rs28538005; rs11288129; rs35203172; rs17400606; rs17062219; rs9839717; rs34285374; rs34858155; rs4019408; rs7349556; rs4679536; rs2687905; rs35316814; rs17378007; rs35211850; rs5849322; rs10653458; rs35599982; rs9838029; rs3836266; rs6809898; rs213303; rs13061151; rs637319; rs13066026; rs34901097; rs2173055; rs35968635; rs34074007; rs35450027; rs11328658; rs35378512; rs12634693; rs3894421; rs386599; rs35707726; rs241686; rs9823263; rs586389; rs35606091; rs36008750; rs33913871; rs34382742; rs35302096; rs413761; rs35062001; rs35514185; rs4024128; rs2630152; rs2594242; rs28588365; rs35941668; rs652508; rs28481934; rs2362894; rs35674510; rs2687155; rs35014839; rs5849362; rs34717494; rs35450706; rs10688853; rs9819602; rs11369408; rs17062781; rs34687640; rs3836265; rs9868436; rs3821483; rs35599458; rs9833497; rs35653867; rs17061223; rs35401835; rs12630992; rs7639761; rs17062038; rs35704552; rs533740; rs35397711; rs35500094; rs10609396; rs13089872; rs34424783; rs2605439; rs12108078; rs35601823; rs36022455; rs13088038; rs2630159; rs6794069; rs17061347; rs11276616; rs599589; rs34975359; rs12492513; rs11456777; rs11715442; rs12487808; rs242240; rs484579; rs2687180; rs2611412; rs35486781; rs35318702; rs6766022; rs663874; rs17063054; rs9841213; rs7646436; rs35711659; rs11455284; rs213422; rs6782781; rs3772478; rs35592181; rs594055; rs36105967; rs35869378; rs12107577; rs35324781; rs1485902; rs13085511; rs35861160; rs35693379; rs35899156; rs9874243; rs7614321; rs598616; rs10561160; rs9874381; rs34661857; rs35270205; rs11305354; rs34350602; rs212012; rs599459; rs2734384; rs650247; rs6794136; rs5849332; rs242218; rs172491; rs13077792; rs12632279; rs34417630; rs35890518; rs2223085; rs11292764; rs13066659; rs11429625; rs11359347; rs9682165; rs35901722; rs13316429; rs36005132; rs35598923; rs582313; rs35231061; rs13076244; rs33999758; rs415353; rs12494457; rs11278637; rs11717308; rs35216768; rs35387531; rs41347345; rs9869159; rs3905395; rs9856850; rs34028777; rs650696; rs9810924; rs34377896; rs34518686; rs34691260; rs17063076; rs7647341; rs28562950; rs5849312; rs36102608; rs28459515; rs34264470; rs398107; rs35620788; rs7647522; rs608981; rs1813833; rs580362; rs1683636; rs9882591; rs4124059; rs5849371; rs11375093; rs6769239; rs3821486; rs11360020; rs35256799; rs34226567; rs12491492; rs34752418; rs9838705; rs11410877; rs2736798; rs11425928; rs10428261; rs979986; rs11715167; rs415879; rs34971963; rs2594262; rs36035542; rs10154941; rs17062138; rs34176966; rs11385307; rs11437945; rs688567; rs621837; rs34737256; rs34744520; rs35212164; rs5849302; rs34603508; rs3943174; rs34945868; rs13069932; rs34681331; rs35296431; rs34872452; rs10663256; rs35848405; rs9846543; rs11317328; rs35287454; rs10470624; rs28452132; rs4021917; rs13068123; rs28644278; rs35158575; rs5849320; rs35247746; rs10539229; rs10703110; rs12054281; rs6803872; rs13087855; rs34384407; rs34034432; rs6446106; rs679085; rs17062253; rs11301238; rs10703540; rs13079850; rs34559077; rs1719824; rs687447; rs11446703; rs11719706; rs34884636; rs242223; rs11293630; rs11329851; rs212002; rs34944550; rs11293701; rs17062486; rs671754; rs11293601; rs10585949; rs11445812; rs6794044; rs35438044; rs3772457; rs34724960; rs2736800; rs34863679; rs35996382; rs1882736; rs3772461; rs13080521; rs10553845; rs664722; rs35417967; rs213330; rs213393; rs9827718; rs7613262; rs17311592; rs35879691; rs406667; rs9813260; rs11400256; rs35789112; rs12330818; rs213332; rs34397808; rs28602951; rs9858462; rs17062817; rs28594929; rs670885; rs34453102; rs28378638; rs4024133; rs35699027; rs151736; rs9817511; rs34832555; rs3060316; rs6797791; rs36002497; rs11288598; rs9837685; rs418428; rs1485720; rs34895232; rs7650092; rs34687143; rs9870841; rs36071604; rs17062124; rs11711514; rs169842; rs9827078; rs35103208; rs241699; rs34668248; rs28557335; rs670469; rs35104072; rs36095441; rs10662436; rs36125400; rs1580456; rs4465902; rs9878319; rs13076237; rs13327071; rs35178232; rs2630188; rs5849326; rs814296; rs694466; rs34992762; rs11347048; rs5849317; rs9861642; rs13325477; rs9812351; rs2611405; rs35787292; rs550738; rs35251804; rs34671935; rs4453800; rs2132607; rs35209040; rs33969323; rs11425227; rs10691937; rs11715317; rs35335356; rs13060801; rs12492537; rs34147843; rs6789385; rs11289210; rs34594149; rs5849336; rs34787563; rs2205039; rs2630162; rs34006407; rs12487671; rs17062571; rs6809115; rs34375145; rs669497; rs213293; rs11293551; rs11323557; rs3075168; rs35015822; rs186060; rs242227; rs4679504; rs13096007; rs28385511; rs34491079; rs34254319; rs34103158; rs35629879; rs6784116; rs9852972; rs34712565; rs34816113; rs34791252; rs1485905; rs28397568; rs212024; rs974513; rs3772492; rs11456264; rs3884255; rs11288438; rs34499848; rs35169596; rs9880557; rs1666095; rs5849357; rs3102827; rs212021; rs599542; rs6791372; rs34488580; rs9850880; rs35731034; rs427057; rs9799361; rs35102526; rs34555513; rs34907688; rs35447167; rs6788207; rs410322; rs35402597; rs34754005; rs11391580; rs6778314; rs4679646; rs34685557; rs35147013; rs2885642; rs17061527; rs3112502; rs5849316; rs901163; rs34768947; rs28704738; rs34237399; rs36107455; rs409769; rs9871322; rs34680230; rs35560846; rs34095596; rs35782604; rs1683343; rs13324099; rs6801047; rs9827193; rs2594249; rs11457779; rs11719596; rs34781790; rs9872055; rs2362882; rs2362897; rs11369935; rs10719245; rs2736770; rs2220239; rs7616889; rs35199648; rs11408869; rs11298084; rs10604761; rs9874945; rs7616984; rs10718750; rs34471619; rs9835872; rs35776137; rs7629735; rs2629890; rs7647658; rs2687904; rs10715035; rs431150; rs28582870; rs34741389; rs17062836; rs17061437; rs680939; rs596938; rs6780851; rs176921; rs11359385; rs35037895; rs3772456; rs213378; rs3112500; rs35480699; rs35966319; rs35722700; rs35571653; rs10553211; rs11347167; rs11324509; rs1022444; rs28607768; rs13060974; rs35363213; rs34704516; rs35096012; rs6793899; rs2734386; rs6147840; rs1485721; rs35598501; rs3060261; rs35602079; rs35682010; rs679533; rs5849369; rs608878; rs41355450; rs9818283; rs35625793; rs10688852; rs34462181; rs1683644; rs370716; rs5849342; rs35153948; rs6769666; rs3060269; rs6766857; rs182417; rs2687896; rs34364126; rs12106780; rs35485080; rs35501653; rs12490488; rs13080038; rs9862809; rs686915; rs2734406; rs2736776; rs41495354; rs660050; rs10565469; rs34187428; rs2630195; rs13318262; rs5849349; rs3845975; rs1683355; rs13073897; rs35803265; rs34222091; rs5849350; rs9825408; rs9833268; rs608935; rs17062820; rs34100509; rs11921987; rs28652838; rs10539228; rs13065959; rs1485901; rs213403; rs125635; rs35675156; rs213397; rs35148673; rs13434176; rs7632624; rs7648302; rs35818352; rs1719825; rs694462; rs1564913; rs2885641; rs9837222; rs10557569; rs35411457; rs7634421; rs1566057; rs10621462; rs2605433; rs6446108; rs13066298; rs2734385; rs188398; rs17062625; rs5849333; rs9838465; rs10596417; rs12107346; rs13066009; rs9864838; rs35576259; rs7638262; rs35317846; rs657207; rs11293702; rs13092735; rs6446091; rs1125547; rs34558815; rs35241371; rs35086063; rs34937181; rs2629887; rs1612985; rs11440050; rs28895693; rs35191236; rs35842023; rs242173; rs13318597; rs35226385; rs2362887; rs36039530; rs9855887; rs35454666; rs1016448; rs11425296; rs2687171; rs34222977; rs34131703; rs33984761; rs33921357; rs34251639; rs34352051; rs35596941; rs35154871; rs35168480; rs2734409; rs936824; rs35011630; rs599096; rs1683639; rs992999; rs41313173; rs3100802; rs11411394; rs34116820; rs3856666; rs1352023; rs9876202; rs10575967; rs34836848; rs1390764; rs7432041; rs28369447; rs2687160; rs3836264; rs11130788; rs2361334; rs453526; rs13315124; rs4679509; rs34717174; rs35840648; rs34542104; rs183595; rs901168; rs4234287; rs6800898; rs6804813; rs9844452; rs28584323; rs34443383; rs34908488; rs11293904; rs36087359; rs34261055; rs34372764; rs36048815; rs1719823; rs10575278; rs10620609; rs241690; rs10621266; rs34865159; rs4257502; rs177035; rs3112506; rs34891258; rs184149; rs3060319; rs36017586; rs750794; rs2687903; rs4020064; rs9823066; rs13092858; rs2034336; rs372819; rs11432014; rs36106720; rs2605438; rs17340935; rs13089005; rs4428132; rs4679532; rs7629854; rs9872043; rs17063118; rs35124652; rs1960248; rs678729; rs34721052; rs35237584; rs186120; rs10619441; rs34655159; rs10574873; rs10691217; rs35461722; rs9869448; rs181448; rs13091743; rs17061587; rs17062694; rs212005; rs13317216; rs615143; rs5849330; rs17061447; rs4679633; rs2736811; rs10617567; rs12494254; rs35203627; rs242217; rs10642737; rs2629898; rs35487806; rs35755244; rs9847682; rs35342045; rs35171599; rs11721192; rs11328477; rs664695; rs7622712; rs11328478; rs41455050; rs35144644; rs7630156; rs2885253; rs1683643; rs11315084; rs11390620; rs9859075; rs11715794; rs7623812; rs17061913; rs34291859; rs662836; rs10048930; rs10155038; rs7433715; rs5007870; rs3894425; rs11441829; rs11293926; rs213360; rs1843398; rs694089; rs35507066; rs17310854; rs6794630; rs34836495; rs10575196; rs35667740; rs2091956; rs11346328; rs3836261; rs10662971; rs13079963; rs35203845; rs11344854; rs35840475; rs35289918; rs682689; rs35286558; rs409440; rs35122696; rs34220971; rs11288556; rs35512291; rs34764324; rs635527; rs505355; rs9843529; rs35931298; rs171353; rs35183377; rs1905941; rs13094560; rs17062857; rs17312006; rs9843548; rs2450226; rs2594271; rs35182472; rs5849365; rs13070077; rs393749; rs13101019; rs616604; rs28444511; rs34260904; rs13092255; rs28473445; rs11711739; rs6147839; rs13322831; rs35249308; rs3772469; rs1683641; rs17377293; rs10613771; rs11359384; rs7621737; rs4626048; rs3772455; rs5849337; rs2630163; rs34397608; rs665161; rs36082003; rs7632784; rs17363144; rs13061337; rs11926900; rs169916; rs576299; rs35167546; rs2687184; rs11922149; rs33997839; rs34613417; rs7648721; rs34774265; rs1882737; rs11368244; rs35313787; rs17062229; rs34381141; rs9815504; rs9838914; rs3821481; rs11411678; rs34126302; rs9814255; rs592876; rs28583724; rs11352722; rs5849300; rs9831864; rs35797840; rs9853585; rs492530; rs11708143; rs34195406; rs17298532; rs4597671; rs34480512; rs213292; rs11425767; rs34512636; rs11373882; rs34511232; rs10574937; rs12496431; rs13069732; rs11288370; rs679107; rs34034610; rs9859836; rs34274889; rs34330024; rs213419; rs10704758; rs13062945; rs28857786; rs34074099; rs6786852; rs4679534; rs6772747; rs34697759; rs35284351; rs7614891; rs5849366; rs34365876; rs509409; rs5849345; rs423910; rs242221; rs11403324; rs11362725; rs6779716; rs35534111; rs34862093; rs639705; rs34648748; rs4465903; rs2736797; rs13092997; rs34502195; rs35494038; rs35546821; rs13080137; rs11706993; rs597790; rs213312; rs11337340; rs13076409; rs6781046; rs34935769; rs35117438; rs13098599; rs34024916; rs34894656; rs2630142; rs11453296; rs35799137; rs5849356; rs9856748; rs7636213; rs7628285; rs7628136; rs11280943; rs34927902; rs5849307; rs909111; rs13069384; rs17062066; rs2630209; rs11371698; rs9820577; rs35607543; rs658725; rs35450604; rs10621849; rs35657144; rs2472011; rs901167; rs11324331; rs13088031; rs17062762; rs35488359; rs13060426; rs2594270; rs17062584; rs4093061; rs35917078; rs10662268; rs28494615; rs35246442; rs2736820; rs34799137; rs2611406; rs34256222; rs4021916; rs213379; rs10714504; rs35138137; rs35496987; rs35748189; rs35011379; rs1967641; rs17374699; rs35044128; rs4679525; rs213372; rs1882902; rs13070073; rs34918586; rs35552116; rs9881953; rs2734381; rs36036988; rs4019410; rs17062788; rs9842228; rs34593763; rs35350097; rs35345892; rs5849324; rs2736815; rs2687175; rs241689; rs242216; rs192675; rs437784; rs11310399; rs9867334; rs35849740; rs482814; rs11915829; rs17062710; rs17062463; rs34796045; rs35693926; rs190890; rs2734405; rs1719826; rs13060999; rs7616516; rs5849363; rs241702; rs439788; rs438501; rs17062052; rs34914890; rs11332615; rs17062068; rs35184553; rs9862243; rs34443264; rs3037458; rs10683236; rs35095248; rs242200; rs34893205; rs35532909; rs35916775; rs9824052; rs3887229; rs13077292; rs11339166; rs35332698; rs9809998; rs34810460; rs36032107; rs6767414; rs12486475; rs9882855; rs9863027; rs35775328; rs2736829; rs28472960; rs36203945; rs813608; rs34008895; rs11371406; rs4024134; rs35192595; rs17062536; rs13094466; rs35465254; rs190899; rs34648704; rs9828120; rs41347853; rs2046456; rs35740143; rs2736771; rs4679513; rs621855; rs13060988; rs34564498; rs441395; rs629300; rs10656986; rs17061940; rs4365581; rs35379090; rs13325133; rs410326; rs13061330; rs13314418; rs10695874; rs13070043; rs9847591; rs694423; rs35909623; rs13093023; rs35058364; rs35536483; rs587775; rs35953173; rs6782693; rs17063381; rs36075870; rs5849334; rs2734360; rs694576; rs1485714; rs10548266; rs10662389; rs35561334; rs6650906; rs10713144; rs35196912; rs13063683; rs11438598; rs34413493; rs454914; rs212035; rs582805; rs36223393; rs5849310; rs509412; rs672759; rs11458053; rs34925009; rs2630146; rs607731; rs35122152; rs35774308; rs35191621; rs2362239; rs34023165; rs242199; rs34269369; rs7628257; rs11305308; rs12107521; rs13088505; rs35343343; rs1817617; rs3102826; rs7626705; rs28495306; rs2886820; rs13076222; rs34144150; rs34536694; rs3100803; rs651177; rs35881306; rs2367088; rs2734408; rs12629645; rs34914689; rs11441692; rs528473; rs1683638; rs35612371; rs11440270; rs33987270; rs570702; rs17062204; rs13062539; rs34278984; rs7427388; rs35825465; rs35886433; rs405371; rs612707; rs34539132; rs2450165; rs35511149; rs9826481; rs35717439; rs9826192; rs2450223; rs4622857; rs2367084; rs41467656; rs34884909; rs35885387; rs2366963; rs651680; rs652995; rs9862311; rs35048042; rs403985; rs6769064; rs5849327; rs2461814; rs2594236; rs35130369; rs5849304; rs1447969; rs11303865; rs34045548; rs5849353; rs5849338; rs2687153; rs3836267; rs13098273; rs33954692; rs2736772; rs35803823; rs36152393; rs33999420; rs34523561; rs4093062; rs36100330; rs35688021; rs9820087; rs9851914; rs3772463; rs9856567; rs4345028; rs598667; rs10621207; rs11391493; rs13066408; rs17062079; rs12630462; rs41464544; rs34416528; rs35886908; rs5849331; rs11409205; rs13059468; rs17062608; rs7429694; rs11306382; rs10539248; rs5849306; rs5849341; rs35444265; rs35595242; rs926051; rs2471813; rs12636054; rs661793; rs35582169; rs2734357; rs596484; rs672225; rs35579400; rs2736773; rs35035916; rs11459824; rs13087298; rs7609900; rs1157725; rs9833904; rs10575171; rs35607797; rs9826037; rs34056992; rs35302219; rs13314508; rs5849299; rs35179858; rs17062867; rs378987; rs35969709; rs419378; rs2630157; rs17061862; rs11293927; rs34821370; rs419289; rs11317928; rs11447360; rs34706556; rs34305760; rs11432702; rs2362886; rs41528049; rs2630150; rs13321570; rs35003645; rs614379; rs2078287; rs35308092; rs35828639; rs34971218; rs2885638; rs192674; rs663259; rs9861639; rs673756; rs33957118; rs35230052; rs10614391; rs36226341; rs171354; rs17321950; rs525882; rs36101680; rs4426639; rs6765118; rs35745980; rs13061672; rs12107803; rs10530242; rs13088112; rs34878050; rs3894424; rs2687162; rs28709472; rs13069256; rs678205; rs35543812; rs35086778; rs550155; rs35788291; rs2886861; rs4019406; rs35452876; rs5849348; rs35510391; rs10212368; rs7642636; rs7647555; rs4368451; rs7340590; rs1683346; rs661807; rs409069; rs11438335; rs10575692; rs28562847; rs34188830; rs425711; rs2687902; rs28522697; rs12629110; rs1683640; rs615553; rs11716940; rs242211; rs10621463; rs35524867; rs28635962; rs2611413; rs1683345; rs11456273; rs11334849; rs11276736; rs5029598; rs9818923; rs35292894; rs34289599; rs11719378; rs34507740; rs633638; rs35508599; rs1825633; rs5849318; rs9828307; rs169838; rs2594243; rs34799084; rs34944059; rs1038518; rs34514881; rs17062159; rs381660; rs401985; rs9875995; rs688311; rs35261444; rs9848288; rs34408566; rs6766813; rs35064454; rs6791055; rs4679634; rs7616798; rs9881424; rs615356; rs6804443; rs11276292; rs36220407; rs34924899; rs615964; rs35520149; rs36059015; rs5849313; rs2981569; rs35903040; rs4679503; rs6785999; rs13069423; rs34997506; rs5849295; rs11401439; rs1155530; rs11917500; rs11918782; rs11921025; rs11926456; rs11928674; rs12489342; rs12632717; rs12632761; rs13314029; rs13321532; rs13324900; rs13324942; rs1385718; rs1632176; rs1683361; rs17061148; rs17061153; rs17063890; rs1716730; rs1716741; rs172407; rs17274570; rs1735454; rs1735476; rs186059; rs1868227; rs213321; rs2363681; rs2605444; rs293600; rs293601; rs2949013; rs2981568; rs34491188; rs4343583; rs4542973; rs4688167; rs503665; rs6445200; rs6764043; rs6774103; rs6785875; rs6790549; rs6797892; rs689364; rs7619791; rs7623666; rs7629722; rs780373; rs780710; rs970387; rs9824756; rs9858223; rs9860907; rs9865712; rs9873085; rs9880069; rs9990332

# Metabolic_Enzyme_71_General_References:
8598045; 9012482; 8794732; 9261067; 9323207; 9576908

# Metabolic_Enzyme_71_References:
Not Available

# Metabolic_Enzyme_72_ID:
5888

# Metabolic_Enzyme_72_Name:
High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

# Metabolic_Enzyme_72_Synonyms:
Not Available

# Metabolic_Enzyme_72_Gene_Name:
PDE9A

# Metabolic_Enzyme_72_Protein_Sequence:
>Highaffinity cGMPspecific 3',5'cyclic phosphodiesterase 9
AMGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDA
MVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRR
EGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVAN
HLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRD
VPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWL
FCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGY
NNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITL
ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC
LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM
LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA

# Metabolic_Enzyme_72_Number_of_Residues:
593

# Metabolic_Enzyme_72_Molecular_Weight:
68493

# Metabolic_Enzyme_72_Theoretical_pI:
6.10

# Metabolic_Enzyme_72_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_72_General_Function:
Not Available

# Metabolic_Enzyme_72_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has a high affinity for cGMP

# Metabolic_Enzyme_72_Pathway:
Not Available

# Metabolic_Enzyme_72_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_72_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_72_Signals:
None

# Metabolic_Enzyme_72_Transmembrane_Regions:
None

# Metabolic_Enzyme_72_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_72_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_72_GenBank_ID_Protein:
3242777

# Metabolic_Enzyme_72_SwissProt_ID:
PDE9A_HUMAN (O76083)

# Metabolic_Enzyme_72_swissprot_Name:
Not Available

# Metabolic_Enzyme_72_Genecard_id:
PDE9A

# Metabolic_Enzyme_72_Geneatlas_id:
PDE9A

# Metabolic_Enzyme_72_hgnc_id:
HGNC:8795

# Metabolic_Enzyme_72_PDB_ID:
Not Available

# Metabolic_Enzyme_72_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_72_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_72_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_72_Gene_Sequence:
>1782 bp
ATGGGATCCGGCTCCTCCAGCTACCGGCCCAAGGCCATCTACCTGGACATCGATGGACGC
ATTCAGAAGGTAATCTTCAGCAAGTACTGCAACTCCAGCGACATCATGGACCTGTTCTGC
ATCGCCACCGGCCTGCCTCGGAACACGACCATCTCCCTGCTGACCACCGACGACGCCATG
GTCTCCATCGACCCCACCATGCCCGCGAATTCAGAACGCACTCCGTACAAAGTGAGACCT
GTGGCCATCAAGCAACTCTCCGCTGGTGTCGAGGACAAGAGAACCACAAGCCGTGGCCAG
TCTGCTGAGAGACCACTGAGGGACAGACGGGTTGTGGGCCTGGAGCAGCCCCGGAGGGAA
GGAGCATTTGAAAGTGGACAGGTAGAGCCCAGGCCCAGAGAGCCCCAGGGCTGCTACCAG
GAAGGCCAGCGCATCCCTCCAGAGAGAGAAGAATTAATCCAGAGCGTGCTGGCGCAGGTT
GCAGAGCAGTTCTCAAGAGCATTCAAAATCAATGAACTGAAAGCTGAAGTTGCAAATCAC
TTGGCTGTCCTAGAGAAACGCGTGGAATTGGAAGGACTAAAAGTGGTGGAGATTGAGAAA
TGCAAGAGTGACATTAAGAAGATGAGGGAGGAGCTGGCGGCCAGAAGCAGCAGGACCAAC
TGCCCCTGTAAGTACAGTTTTTTGGATAACCACAAGAAGTTGACTCCTCGACGCGATGTT
CCCACTTACCCCAAGTACCTGCTCTCTCCAGAGACCATCGAGGCCCTGCGGAAGCCGACC
TTTGACGTCTGGCTTTGGGAGCCCAATGAGATGCTGAGCTGCCTGGAGCACATGTACCAC
GACCTCGGGCTGGTCAGGGACTTCAGCATCAACCCTGTCACCCTCAGGAGGTGGCTGTTC
TGTGTCCACGACAACTACAGAAACAACCCCTTCCACAACTTCCGGCACTGCTTCTGCGTG
GCCCAGATGATGTACAGCATGGTCTGGCTCTGCAGTCTCCAGGAGAAGTTCTCACAAACG
GATATCCTGATCCTAATGACAGCGGCCATCTGCCACGATCTGGACCATCCCGGCTACAAC
AACACGTACCAGATCAATGCCCGCACAGAGCTGGCGGTCCGCTACAATGACATCTCACCG
CTGGAGAACCACCACTGCGCCGTGGCCTTCCAGATCCTCGCCGAGCCTGAGTGCAACATC
TTCTCCAACATCCCACCTGATGGGTTCAAGCAGATCCGACAGGGAATGATCACATTAATC
TTGGCCACTGACATGGCAAGACATGCAGAAATTATGGATTCTTTCAAAGAGAAAATGGAG
AATTTTGACTACAGCAACGAGGAGCACATGACCCTGCTGAAGATGATTTTGATAAAATGC
TGTGATATCTCTAACGAGGTCCGTCCAATGGAAGTCGCAGAGCCTTGGGTGGACTGTTTA
TTAGAGGAATATTTTATGCAGAGCGACCGTGAGAAGTCAGAAGGCCTTCCTGTGGCACCG
TTCATGGACCGAGACAAAGTGACCAAGGCCACAGCCCAGATTGGGTTCATCAAGTTTGTC
CTGATCCCAATGTTTGAAACAGTGACCAAGCTCTTCCCCATGGTTGAGGAGATCATGCTG
CAGCCACTTTGGGAATCCCGAGATCGCTACGAGGAGCTGAAGCGGATAGATGACGCCATG
AAAGAGTTACAGAAGAAGACTGACAGCTTGACGTCTGGGGCCACCGAGAAGTCCAGAGAG
AGAAGCAGAGATGTGAAAAACAGTGAAGGAGACTGTGCCTGA

# Metabolic_Enzyme_72_GenBank_ID_Gene:
AF048837

# Metabolic_Enzyme_72_Chromosome_Location:
Not Available

# Metabolic_Enzyme_72_Locus:
Not Available

# Metabolic_Enzyme_72_SNPs:
Not Available

# Metabolic_Enzyme_72_General_References:
9624146; 9856478; 12565835; 14527714; 10830953

# Metabolic_Enzyme_72_References:
Not Available

# Metabolic_Enzyme_73_ID:
5889

# Metabolic_Enzyme_73_Name:
cGMP-dependent 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_73_Synonyms:
Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE

# Metabolic_Enzyme_73_Gene_Name:
PDE2A

# Metabolic_Enzyme_73_Protein_Sequence:
>cGMPdependent 3',5'cyclic phosphodiesterase
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE

# Metabolic_Enzyme_73_Number_of_Residues:
941

# Metabolic_Enzyme_73_Molecular_Weight:
105718

# Metabolic_Enzyme_73_Theoretical_pI:
5.08

# Metabolic_Enzyme_73_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_73_General_Function:
Not Available

# Metabolic_Enzyme_73_Specific_Function:
Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)

# Metabolic_Enzyme_73_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_73_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_73_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_73_Signals:
None

# Metabolic_Enzyme_73_Transmembrane_Regions:
None

# Metabolic_Enzyme_73_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_73_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_73_GenBank_ID_Protein:
2108052

# Metabolic_Enzyme_73_SwissProt_ID:
PDE2A_HUMAN (O00408)

# Metabolic_Enzyme_73_swissprot_Name:
Not Available

# Metabolic_Enzyme_73_Genecard_id:
PDE2A

# Metabolic_Enzyme_73_Geneatlas_id:
PDE2A

# Metabolic_Enzyme_73_hgnc_id:
HGNC:8777

# Metabolic_Enzyme_73_PDB_ID:
Not Available

# Metabolic_Enzyme_73_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_73_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_73_Subcellular_Location:
Membrane; peripheral membrane protein (Potential)

# Metabolic_Enzyme_73_Gene_Sequence:
>2826 bp
ATGGGGCAGGCATGCGGCCACTCCATCCTCTGCAGGAGCCAGCAGTACCCGGCAGCGCGA
CCGGCTGAGCCGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCG
CAGCCATGCGCCGACAGCCTGCAGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATT
TCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGAAACT
GTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAG
CTGCCCCAGGAGGGGAAAGTCCGGGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAAT
GGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCT
CCTGATACCCAAGTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCT
GTCATCTTGGTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTG
GAGAAGCATACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGG
GAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGG
GCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGGGAACTCTACGACCTG
GATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATACCTGCAGCAGGAGACCCGGGCATCC
CGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGTCATCGGA
GACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCTTGACAGGATGCCTGGGCCAGGTGGTG
GAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCCGAGGATGTACAACAGCTGCAG
AGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACT
GACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTTGTTCACCGAC
GAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACC
CTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCA
AAGAACCTCTTCACCCACCTGGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAG
GCCAGAAACCTCAGCAACGCAGAGATCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTG
GTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGAGCTATGAGATCCGCATCCCG
GCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGAC
GCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGC
AACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTG
GTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTC
TCCATCTACTGCGGCATCAGCATCGCCCATTCTCTCCTATACAAAAAAGTGAATGAGGCT
CAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGGTCTCCGACGAT
GAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTT
GCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGGCCATCCTG
AGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCC
CGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCAC
GCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTAC
CTCGAGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCAC
AGAGGCACAAACAACTCTTTCCAGGTGGCCTCGAAATCTGTGCTGGCTGCGCTCTACAGC
TCTGAGGGCTCCGTCATGGAGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACC
CACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGGACTATCAGCGCATGCTGGATCTG
ATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTC
CAGAAGATGGCTGAGGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTC
TGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGA
AAGATCGCGGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGGAGAAGGCCATG
GGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATC
AGCTTCATGGAGCACATTGCAATGCCCATCTACAAGCTGTTGCAGGACCTGTTCCCCAAA
GCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCAC
AAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTAC
GAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCT
GAGTGA

# Metabolic_Enzyme_73_GenBank_ID_Gene:
U67733

# Metabolic_Enzyme_73_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_73_Locus:
11q13.4

# Metabolic_Enzyme_73_SNPs:
rs341047; rs1135029; rs4944557; rs392565; rs1980091; rs392818; rs11824084; rs458575; rs341087; rs366068; rs371862; rs467139; rs3781913; rs7111188; rs4944584; rs2047506; rs1513780; rs1009708; rs4944643; rs458275; rs11235555; rs341061; rs746399; rs907857; rs11822008; rs189332; rs2035467; rs904469; rs341086; rs11820891; rs11235551; rs907851; rs458437; rs3781931; rs184654; rs426907; rs7934444; rs405851; rs755933; rs11235543; rs7105428; rs376724; rs429075; rs370013; rs907856; rs4943939; rs401801; rs459546; rs4944591; rs462491; rs3825009; rs12363065; rs3781926; rs1038377; rs932074; rs433270; rs455611; rs401999; rs4944608; rs382163; rs7119321; rs11826028; rs10898860; rs10898857; rs755932; rs459309; rs341088; rs676911; rs456405; rs932075; rs1513781; rs676845; rs342326; rs907858; rs4944563; rs341049; rs907850; rs1467135; rs1877652; rs4944639; rs3781916; rs4944635; rs2365774; rs424234; rs1391888; rs342321; rs4943961; rs11603497; rs11828329; rs3781939; rs11235548; rs457556; rs341085; rs460633; rs2365769; rs399874; rs168173; rs90409; rs3781923; rs7930245; rs10793036; rs377432; rs754042; rs458360; rs462177; rs11821068; rs171021; rs3781932; rs341052; rs11235559; rs10898861; rs402250; rs572421; rs428355; rs7115561; rs408269; rs342322; rs1980090; rs7126790; rs341048; rs10898855; rs1980089; rs341059; rs11235557; rs11823678; rs12804316; rs4944599; rs11602224; rs10898856; rs3842265; rs11235558; rs341051; rs10793037; rs878277; rs12290945; rs1513779; rs10898858; rs342327; rs7108786; rs163692; rs7108477; rs455631; rs17162381; rs341050; rs11604837; rs236034; rs877133; rs907849; rs459886; rs163693; rs2365773; rs12797791; rs12797368; rs3781938; rs644698; rs462720; rs464853; rs341089; rs12146545; rs11604034; rs577536; rs3741159; rs11235550; rs11605051; rs4944589; rs11600831; rs11235547; rs17162383; rs1079117; rs11602616; rs11601122; rs371903; rs341039; rs466023; rs341060; rs11235546; rs7924891; rs371412; rs409816; rs907854; rs168175; rs11235552; rs17162385; rs12289096; rs2280098; rs414178; rs466929; rs12797628; rs7946369; rs7926573; rs151449; rs10751207; rs342323; rs11824863; rs11826928; rs907853; rs3781934; rs7111810; rs452228; rs11235549; rs1391887; rs341035; rs7123699; rs3781933; rs415399; rs341058; rs402479; rs3758936; rs3758935; rs443510; rs17857242; rs17854062; rs1056864; rs34999278; rs1299161; rs35034069; rs1056859; rs36006389; rs35330308; rs1695326; rs10629768; rs35374828; rs10599676; rs11235556; rs11235563; rs2648427; rs11235544; rs34217943; rs465873; rs11235560; rs180539; rs3842266; rs34273765; rs34673418; rs1467134; rs35973297; rs34219591; rs379638; rs415603; rs12276767; rs34845765; rs7111915; rs11235542; rs36088997; rs163608; rs2037030; rs7110834; rs35791363; rs12800996; rs341084; rs12291404; rs3825011; rs11235562; rs35209015; rs34659576; rs390130; rs34678444; rs5792598; rs34885656; rs631552; rs28435513; rs35457068; rs34561755; rs34903353; rs1079116; rs33965768; rs34055117; rs7941968; rs28681095; rs367195; rs341062; rs3781937; rs7930640; rs3837412; rs3781915; rs34720752; rs366711; rs236908; rs12362256; rs35491439; rs34815390; rs10751208; rs35179366; rs10577236; rs34468837; rs341038; rs7110760; rs1513782; rs3741160; rs11235545; rs11421754; rs34212074; rs34648431; rs3741158; rs7933910; rs459854; rs33948641; rs12787971; rs341037; rs7128760; rs12805517; rs34992676; rs34755048; rs35351102; rs4944570; rs5792597; rs12420120; rs34958282; rs3781924; rs12796885; rs384892; rs12223388; rs36025018; rs7482093; rs34346276; rs12789554; rs11824399; rs34173798; rs12275807; rs12293769; rs10552751; rs7935955; rs34927568; rs35642115; rs12276624; rs4944566; rs35534137; rs11603077; rs12790170; rs465512; rs34193719; rs3832776; rs35014697; rs168174; rs12280849; rs7110717; rs438969; rs2271524; rs3837413; rs342320; rs907855; rs36022812; rs35320110; rs12279246; rs10533778; rs35814877; rs35309746; rs12287467; rs7123937; rs7115954; rs379276; rs12276229; rs10666854; rs2128913; rs3062165; rs6144389; rs394903; rs10706560; rs12099061; rs341036; rs34274987; rs34893653; rs4990737; rs1681502; rs35905219; rs11605720; rs34977751; rs7951461; rs34098578; rs10636062; rs35667827; rs35562683; rs11235553; rs5792596; rs11362512; rs34720227; rs35148742; rs456119; rs12281128; rs11235561; rs35057014; rs34150026; rs35365831; rs12290975; rs12786089; rs34706617; rs35360874; rs341057; rs186882; rs11235541; rs35255183; rs11235540; rs11235565; rs11604811; rs11823971; rs12421911; rs12576046; rs12576058; rs12787293; rs12799451; rs1473885; rs163694; rs341054; rs341056; rs34285624; rs35730889; rs365274; rs366066; rs3758934; rs380126; rs387354; rs393479; rs393561; rs409512; rs433640; rs433837; rs6592481; rs670066; rs7104461; rs7117518; rs7952279

# Metabolic_Enzyme_73_General_References:
9210593

# Metabolic_Enzyme_73_References:
Not Available

# Metabolic_Enzyme_74_ID:
5890

# Metabolic_Enzyme_74_Name:
Ubiquitin-activating enzyme E1

# Metabolic_Enzyme_74_Synonyms:
A1S9 protein

# Metabolic_Enzyme_74_Gene_Name:
UBE1

# Metabolic_Enzyme_74_Protein_Sequence:
>Ubiquitinactivating enzyme E1
MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLY
VLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLRE
EDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCH
NRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARH
GFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKK
ISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVA
LAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPI
MQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIG
CELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMN
PHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGT
LGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPA
ENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSN
NIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTG
SQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLP
GFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAA
VVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEV
QGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVS
RVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR

# Metabolic_Enzyme_74_Number_of_Residues:
1058

# Metabolic_Enzyme_74_Molecular_Weight:
117850

# Metabolic_Enzyme_74_Theoretical_pI:
5.50

# Metabolic_Enzyme_74_GO_Classification:
>>>
Function:  ubiquitin-like activating enzyme activity
Function:  small protein activating enzyme activity
Function:  ubiquitin activating enzyme activity
Function:  catalytic activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_74_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_74_Specific_Function:
Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP

# Metabolic_Enzyme_74_Pathway:
Not Available

# Metabolic_Enzyme_74_Reaction:
Not Available

# Metabolic_Enzyme_74_Pfam_Domain_Function:
PF00899:ThiF;
PF02134:UBACT

# Metabolic_Enzyme_74_Signals:
None

# Metabolic_Enzyme_74_Transmembrane_Regions:
None

# Metabolic_Enzyme_74_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_74_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_74_GenBank_ID_Protein:
35830

# Metabolic_Enzyme_74_SwissProt_ID:
UBE1_HUMAN (P22314)

# Metabolic_Enzyme_74_swissprot_Name:
Not Available

# Metabolic_Enzyme_74_Genecard_id:
UBE1

# Metabolic_Enzyme_74_Geneatlas_id:
UBE1

# Metabolic_Enzyme_74_hgnc_id:
HGNC:12469

# Metabolic_Enzyme_74_PDB_ID:
Not Available

# Metabolic_Enzyme_74_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_74_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_74_Subcellular_Location:
Not Available

# Metabolic_Enzyme_74_Gene_Sequence:
>3177 bp
ATGTCCAGCTCGCCGCTGTCCAAGAAACGTCGCGTGTCCGGGCCTGATCCAAAGCCGGGT
TCTAACTGCTCCCCTGCCCAGTCCGTGTTGTCCGAAGTGCCCTCGGTGCCAACCAACGGA
ATGGCCAAGAACGGCAGTGAAGCAGACATAGACGAGGGCCTTTACTCCCGGCAGCTGTAT
GTGTTGGGCCATGAGGCAATGAAGCGGCTCCAGACATCCAGTGTCCTGGTATCAGGCCTG
CGGGGCCTGGGCGTGGAGATCGCTAAGAACATCATCCTTGGTGGGGTCAAGGCTGTTACC
CTACATGACCAGGGCACTGCCCAGTGGGCTGATCTTTCCTCCCAGTTCTACCTGCGGGAG
GAGGACATCGGTAAAAACCGGGCCGAGGTATCACAGCCCCGCCTCGCTGAGCTCAACAGC
TATGTGCCTGTCACTGCCTACACTGGACCCCTCGTTGAGGACTTCCTTAGTGGTTTCCAG
GTGGTGGTGCTCACCAACACCCCCCTGGAGGACCAGCTGCGAGTGGGTGAGTTCTGTCAC
AACCGTGGCATCAAGCTGGTGGTGGCAGGCACGCGGGGCCTGTTTGGGCAGCTCTTCTGT
GACTTTGGAGAGGAAATGATCCTCACAGATTCCAATGGGGAGCAGCCACTCAGTGCTATG
GTTTCTATGGTTACCAAGGACAACCCCGGTGTGGTTACCTGCCTGGATGAGGCCCGACAC
GGGTTTGAGAGCGGGGACTTTGTCTCCTTTTCAGAAGTACAGGGCATGGTTGAACTCAAC
GGAAATCAGCCCATGGAGATCAAAGTCCTGGGTCCTTATACCTTTAGCATCTGTGACACC
TCCAACTTCTCCGACTACATCCGTGGAGGCATCGTCAGTCAGGTCAAAGTACCTAAGAAG
ATTAGCTTTAAATCCTTGGTGGCCTCACTGGCAGAACCTGACTTTGTGGTGACGGACTTC
GCCAAGTTTTCTCGCCCTGCCCAGCTGCACATTGGCTTCCAGGCCCTGCACCAGTTCTGT
GCTCAGCATGGCCGGCCACCTCGGCCCCGCAATGAGGAGGATGCAGCAGAACTGGTAGCC
TTAGCACAGGCTGTGAATGCTCGAGCCCTGCCAGCAGTGCAGCAAAATAACCTGGACGAG
GACCTCATCCGGAAGCTGGCATATGTGGCTGCTGGGGATCTGGCACCCATAAACGCCTTC
ATTGGGGGCCTGGCTGCCCAGGAAGTCATGAAGGCCTGCTCCGGGAAGTTCATGCCCATC
ATGCAGTGGCTATACTTTGATGCCCTTGAGTGTCTCCCTCAGGACAAAGAGGTCCTCACA
GAGGACAAGTGCCTCCAGCGCCAGAACCGTTATGACGGGCAAGTGGCTGTGTTTGGCTCA
GACCTGCAAGAGAAGCTGGGCAAGCAGAAGTATTTCCTGGTGGGTGCGGGGGCCATTGGC
TGTGAGCTGCTCAAGAACTTTGCCATGATTGGGCTGGGCTGCGGGGAGGGTGGAGAAATC
ATCGTTACAGACATGGACACCATTGAGAAGTCAAATCTGAATCGACAGTTTCTTTTCCGG
CCCTGGGATGTCACGAAGTTAAAGTCTGACACGGCTGCTGCAGCTGTGCGCCAAATGAAT
CCACATATCCGGGTGACAAGCCACCAGAACCGTGTGGGTCCTGACACGGAGCGCATCTAT
GATGACGATTTTTTCCAAAACCTAGATGGCGTGGCCAATGCCCTGGACAACGTGGATGCC
CGCATGTACATGGACCGCCGCTGTGTCTACTACCGGAAGCCACTGCTGGAGTCAGGCACA
CTGGGCACCAAAGGCAATGTGCAGGTGGTGATCCCCTTCCTGACAGAGTCGTACAGTTCC
AGCCAGGACCCACCTGAGAAGTCCATCCCCATCTGTACCCTGAAGAACTTCCCTAATGCC
ATCGAGCACACCCTGCAGTGGGCTCGGGATGAGTTTGAAGGCCTCTTCAAGCAGCCAGCA
GAAAATGTCAACCAGTACCTCACAGACCCCAAGTTTGTGGAGCGAACACTGCGGCTGGCA
GGCACTCAGCCCTTGGAGGTGCTGGAGGCTGTGCAGCGCAGCCTGGTGCTGCAGCGACCA
CAGACCTGGGCTGACTGCGTGACCTGGGCCTGCCACCACTGGCACACCCAGTACTCGAAC
AACATCCGGCAGCTGCTGCACAACTTCCCTCCTGACCAGCTCACAAGCTCAGGAGCGCCG
TTCTGGTCTGGGCCCAAACGCTGTCCACACCCGCTCACCTTTGATGTCAACAATCCCCTG
CATCTGGACTATGTGATGGCTGCTGCCAACCTGTTTGCCCAGACCTACGGGCTGACAGGC
TCTCAGGACCGAGCTGCTGTGGCCACATTCCTGCAGTCTGTGCAGGTCCCCGAATTCACC
CCCAAGTCTGGCGTCAAGATCCATGTTTCTGACCAGGAGCTGCAGAGCGCCAATGCCTCT
GTTGATGACAGTCGTCTAGAGGAGCTCAAAGCCACTCTGCCCAGCCCAGACAAGCTCCCT
GGATTCAAGATGTACCCCATTGACTTTGAGAAGGATGATGACAGCAACTTTCATATGGAT
TTCATCGTGGCTGCATCCAACCTCCGGGCAGAAAACTATGACATTCCTTCTGCAGACCGG
CACAAGAGCAAGCTGATTGCAGGGAAGATCATCCCAGCCATTGCCACGACCACAGCAGCC
GTGGTTGGCCTTGTGTGTCTGGAGCTGTACAAGGTTGTGCAGGGGCACCGACAGCTTGAC
TCCTACAAGAATGGTTTCCTCAACTTGGCCCTGCCTTTCTTTGGTTTCTCTGAACCCCTT
GCCGCACCACGTCACCAGTACTATAACCAAGAGTGGACATTGTGGGATCGCTTTGAGGTA
CAAGGGCTGCAGCCTAATGGTGAGGAGATGACCCTCAAACAGTTCCTCGACTATTTTAAG
ACAGAGCACAAATTAGAGATCACCATGCTGTCCCAGGGCGTGTCCATGCTCTATTCCTTC
TTCATGCCAGCTGCCAAGCTCAAGGAACGGTTGGATCAGCCGATGACAGAGATTGTGAGC
CGTGTGTCGAAGCGAAAGCTGGGCCGCCACGTGCGGGCGCTGGTGCTTGAGCTGTGCTGT
AACGACGAGAGCGGCGAGGATGTCGAGGTTCCCTATGTCCGATACACCATCCGCTGA

# Metabolic_Enzyme_74_GenBank_ID_Gene:
X56976

# Metabolic_Enzyme_74_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_74_Locus:
Xp11.23

# Metabolic_Enzyme_74_SNPs:
rs2230147; rs2228658; rs7891904; rs4239963; rs7877968; rs4529579; rs12006836; rs5953011; rs6611347; rs7053477; rs17144858; rs7064703; rs12556965; rs12007789; rs5906354; rs11558782; rs34590238; rs1804872; rs4468050; rs35305529; rs14952; rs1127319; rs34255007; rs28633931; rs41310655; rs4347097; rs34770292; rs4239964; rs7886193; rs41312161; rs5953012; rs34440828; rs5906356; rs12688907; rs34299503; rs34304680; rs6611345; rs35869841; rs11558783; rs12391384; rs2273272; rs36107410; rs4824601; rs5906352; rs5906355; rs5952422; rs5953007; rs5953008; rs5953009; rs5953014; rs5953015; rs6611344; rs7056407; rs7887940

# Metabolic_Enzyme_74_General_References:
1606621; 1986373; 1871145; 2390975

# Metabolic_Enzyme_74_References:
Not Available

# Metabolic_Enzyme_75_ID:
5891

# Metabolic_Enzyme_75_Name:
Tyrosyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_75_Synonyms:
Tyrosine--tRNA ligase; TyrRS

# Metabolic_Enzyme_75_Gene_Name:
YARS2

# Metabolic_Enzyme_75_Protein_Sequence:
>TyrosyltRNA synthetase, mitochondrial precursor
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

# Metabolic_Enzyme_75_Number_of_Residues:
477

# Metabolic_Enzyme_75_Molecular_Weight:
53200

# Metabolic_Enzyme_75_Theoretical_pI:
9.34

# Metabolic_Enzyme_75_GO_Classification:
>>>
Function:  tyrosine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tyrosyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_75_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_75_Specific_Function:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_75_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_75_Reaction:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)

# Metabolic_Enzyme_75_Pfam_Domain_Function:
PF00579:tRNA-synt_1b

# Metabolic_Enzyme_75_Signals:
1-33

# Metabolic_Enzyme_75_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_75_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_75_EC_Link:
EC 6.1.1.1

# Metabolic_Enzyme_75_GenBank_ID_Protein:
4680649

# Metabolic_Enzyme_75_SwissProt_ID:
SYYM_HUMAN (Q9Y2Z4)

# Metabolic_Enzyme_75_swissprot_Name:
Not Available

# Metabolic_Enzyme_75_Genecard_id:
YARS2

# Metabolic_Enzyme_75_Geneatlas_id:
YARS2

# Metabolic_Enzyme_75_hgnc_id:
HGNC:24249

# Metabolic_Enzyme_75_PDB_ID:
Not Available

# Metabolic_Enzyme_75_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_75_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_75_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_75_Gene_Sequence:
>1431 bp
ATGGGCGCCATCTTGCGGTCCTTTTCCTGGGGCCGGTGGTCTGGTACCCTAAATCTCTCA
GTATTGTTGCCCTTGGGGCTGCGTAAGGCCCACTCGGGCGCTCAGGGGTTACTGGCAGCG
CAGAAGGCTCGAGGTCTGTTCAAGGACTTCTTCCCGGAGACGGGGACGAAAATAGAGCTC
CCAGAGCTCTTCGACCGTGGCACGGCGAGTTTTCCCCAAACCATTTACTGTGGCTTCGAC
CCCACGGCAGACTCGCTTCATGTGGGTCATCTACTTGCGCTGCTGGGTCTGTTTCATTTG
CAGCGAGCGGGCCACAACGTGATCGCGCTGGTGGGAGGCGCCACGGCGGCCCTGGGAGAC
CCGAGCGGCCGTACCAAGGAACGCGAGGCGCTGGAGACAGAGCGCGTGCGAGCCAACGCG
CGAGCTCTGCGCCTAGGGCTTGAGGCCCTGGCGGCTAATCACCAGCAGCTTTTCACTGAT
GGGCGCTCCTGGGGCAGCTTCACTGTGCTGGACAACTCGGCCTGGTACCAGAAGCAGCAC
CTGGTGGACTTCCTGGCGGCAGTGGGGGTTCACTTCCGCATGGGGACGCTGCTGAGCCGG
CAGAGCGTGCAGCTGCGGCTCAAGAGCCCCGAGGGCATGAGCTTGGCCGAGTTCTTTTAC
CAGGTGCTCCAGGCCTATGACTTCTATTACCTCTTCCAGCGTTATGGATGCAGGGTCCAG
CTGGGCGGATCTGATCAACTAGGCAACATCATGTCCGGATATGAGTTCATCAACAAGTTG
ACTGGAGAAGATGTATTTGGAATCACCGTTACTCTAATTACAAGTACAACTGGAGCAAAG
CTGGGAAAGTCTGCTGGCAACGCTGTTTGGCTAAACAGAGATAAGACATCTCCATTTGAA
TTGTATCAATTCTTTGTCAGACAACCCGAGGATTCAGTGGAAAGGTACCTGAAGCTGTTC
ACTTTCCTGCCCCTCCCAGAGATTGATCATATCATGCAGCTGCATGTCAAAGAGCCAGAA
AGGCGGGGTCCTCAGAAACGACTGGCAGCAGAAGTAACAAAGCTTGTTCATGGACGAGAA
GGATTGGATTCTGCTAAAAGGTGTACACAAGCCCTTTATCACAGTAGCATAGATGCACTG
GAGGTCATGTCTGATCAGGAGTTAAAAGAGTTGTTTAAAGAAGCTCCATTTTCTGAATTT
TTTCTCGATCCTGGAACAAGTGTCCTAGATACTTGCCGCAAAGCAAATGCCATTCCAGAT
GGTCCCCGAGGGTATCGAATGATAACAGAAGGCGGAGTCAGCATAAATCACCAACAAGTA
ACAAATCCTGAGAGTGTTTTAATTGTTGGACAACATATTCTCAAGAATGGACTTTCCTTA
CTTAAAATAGGAAAAAGAAATTTCTACATTATAAAATGGCTTCAGTTGTGA

# Metabolic_Enzyme_75_GenBank_ID_Gene:
AF132939

# Metabolic_Enzyme_75_Chromosome_Location:
Not Available

# Metabolic_Enzyme_75_Locus:
Not Available

# Metabolic_Enzyme_75_SNPs:
Not Available

# Metabolic_Enzyme_75_General_References:
10810093

# Metabolic_Enzyme_75_References:
Not Available

# Metabolic_Enzyme_76_ID:
5892

# Metabolic_Enzyme_76_Name:
Ubiquitin-conjugating enzyme E2 E1

# Metabolic_Enzyme_76_Synonyms:
Ubiquitin-protein ligase E1; Ubiquitin carrier protein E1; UbcH6

# Metabolic_Enzyme_76_Gene_Name:
UBE2E1

# Metabolic_Enzyme_76_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 E1
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT

# Metabolic_Enzyme_76_Number_of_Residues:
193

# Metabolic_Enzyme_76_Molecular_Weight:
21404

# Metabolic_Enzyme_76_Theoretical_pI:
8.71

# Metabolic_Enzyme_76_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_76_General_Function:
Not Available

# Metabolic_Enzyme_76_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins

# Metabolic_Enzyme_76_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_76_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_76_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_76_Signals:
None

# Metabolic_Enzyme_76_Transmembrane_Regions:
None

# Metabolic_Enzyme_76_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_76_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_76_GenBank_ID_Protein:
1064914

# Metabolic_Enzyme_76_SwissProt_ID:
UB2E1_HUMAN (P51965)

# Metabolic_Enzyme_76_swissprot_Name:
Not Available

# Metabolic_Enzyme_76_Genecard_id:
UBE2E1

# Metabolic_Enzyme_76_Geneatlas_id:
UBE2E1

# Metabolic_Enzyme_76_hgnc_id:
HGNC:12477

# Metabolic_Enzyme_76_PDB_ID:
Not Available

# Metabolic_Enzyme_76_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_76_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_76_Subcellular_Location:
Not Available

# Metabolic_Enzyme_76_Gene_Sequence:
>582 bp
ATGTCGGATGACGATTCGAGGGCCAGCACCAGCTCCTCCTCATCTTCGTCCTCCAACCAG
CAAACCGAGAAAGAAACAAACACCCCCAAGAAGAAGGAGAGTAAAGTCAGCATGAGCAAA
AACTCCAAACTCCTCTCCACCAGCGCCAAGAGAATTCAGAAGGAGCTGGCGGACATCACT
TTAGACCCTCCACCTAATTGCAGTGCTGGTCCCAAAGGCGATAACATCTATGAATGGAGA
TCAACCATTCTAGGGCCTCCAGGATCCGTGTATGAGGGTGGTGTATTCTTTCTCGATATC
ACTTTTACACCAGAATATCCCTTCAAGCCTCCAAAGGTTACATTTCGGACAAGAATCTAT
CATTGTAATATTAACAGTCAAGGTGTTATTTGCTTGGACATATTGAAAGATAATTGGAGT
CCAGCACTAACCATTTCTAAAGTCCTCCTTTCTATCTGCTCACTTCTTACAGACTGTAAT
CCTGCCGACCCCTTGGTGGGAAGTATTGCCACTCAGTATATGACCAACAGAGCAGAACAT
GACAGAATGGCCAGACAGTGGACCAAGAGATACGCTACATAA

# Metabolic_Enzyme_76_GenBank_ID_Gene:
X92963

# Metabolic_Enzyme_76_Chromosome_Location:
Not Available

# Metabolic_Enzyme_76_Locus:
Not Available

# Metabolic_Enzyme_76_SNPs:
Not Available

# Metabolic_Enzyme_76_General_References:
8576257

# Metabolic_Enzyme_76_References:
Not Available

# Metabolic_Enzyme_77_ID:
5893

# Metabolic_Enzyme_77_Name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

# Metabolic_Enzyme_77_Synonyms:
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase; Ap4A hydrolase; Ap4Aase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2

# Metabolic_Enzyme_77_Gene_Name:
NUDT2

# Metabolic_Enzyme_77_Protein_Sequence:
>Bis5'nucleosyltetraphosphatase asymmetrical
MALRACGLIIFRRCLIPKVDNNAIEFLLLQASDGIHHWTPPKGHVEPGEDDLETALRETQ
EEAGIEAGQLTIIEGFKRELNYVARNKPKTVIYWLAEVKDYDVEIRLSHEHQAYRWLGLE
EACQLAQFKEMKAALQEGHQFLCSIEA

# Metabolic_Enzyme_77_Number_of_Residues:
147

# Metabolic_Enzyme_77_Molecular_Weight:
16829

# Metabolic_Enzyme_77_Theoretical_pI:
5.06

# Metabolic_Enzyme_77_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on acid anhydrides
Function:  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function:  pyrophosphatase activity
Function:  nucleotide diphosphatase activity
Function:  bis(5'-nucleosyl)-tetraphosphatase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_77_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_77_Specific_Function:
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis

# Metabolic_Enzyme_77_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_77_Reaction:
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP

# Metabolic_Enzyme_77_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_77_Signals:
None

# Metabolic_Enzyme_77_Transmembrane_Regions:
None

# Metabolic_Enzyme_77_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_77_EC_Link:
EC 3.6.1.17

# Metabolic_Enzyme_77_GenBank_ID_Protein:
1050960

# Metabolic_Enzyme_77_SwissProt_ID:
AP4A_HUMAN (P50583)

# Metabolic_Enzyme_77_swissprot_Name:
Not Available

# Metabolic_Enzyme_77_Genecard_id:
NUDT2

# Metabolic_Enzyme_77_Geneatlas_id:
NUDT2

# Metabolic_Enzyme_77_hgnc_id:
HGNC:8049

# Metabolic_Enzyme_77_PDB_ID:
1XSC

# Metabolic_Enzyme_77_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_77_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_77_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_77_Gene_Sequence:
>60 bp
ATGCCAGCCCTGTTTTACAGGGAGCCCTGGAGGAGTTGGGATAGAGGCCACATTGACTGA


# Metabolic_Enzyme_77_GenBank_ID_Gene:
U30313

# Metabolic_Enzyme_77_Chromosome_Location:
Not Available

# Metabolic_Enzyme_77_Locus:
Not Available

# Metabolic_Enzyme_77_SNPs:
Not Available

# Metabolic_Enzyme_77_General_References:
7487923

# Metabolic_Enzyme_77_References:
Not Available

# Metabolic_Enzyme_78_ID:
5894

# Metabolic_Enzyme_78_Name:
Long-chain-fatty-acid--CoA ligase 6

# Metabolic_Enzyme_78_Synonyms:
Long-chain acyl-CoA synthetase 6; LACS 6

# Metabolic_Enzyme_78_Gene_Name:
ACSL6

# Metabolic_Enzyme_78_Protein_Sequence:
>LongchainfattyacidCoA ligase 6
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

# Metabolic_Enzyme_78_Number_of_Residues:
697

# Metabolic_Enzyme_78_Molecular_Weight:
77753

# Metabolic_Enzyme_78_Theoretical_pI:
7.46

# Metabolic_Enzyme_78_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_78_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_78_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

# Metabolic_Enzyme_78_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_78_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_78_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_78_Signals:
1-37

# Metabolic_Enzyme_78_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_78_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_78_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_78_GenBank_ID_Protein:
5702202

# Metabolic_Enzyme_78_SwissProt_ID:
ACSL6_HUMAN (Q9UKU0)

# Metabolic_Enzyme_78_swissprot_Name:
Not Available

# Metabolic_Enzyme_78_Genecard_id:
ACSL6

# Metabolic_Enzyme_78_Geneatlas_id:
ACSL6

# Metabolic_Enzyme_78_hgnc_id:
HGNC:16496

# Metabolic_Enzyme_78_PDB_ID:
Not Available

# Metabolic_Enzyme_78_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_78_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_78_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_78_Gene_Sequence:
>2094 bp
ATGCAGACACAGGAGATCCTGAGGATACTGCGACTGCCTGAGCTAGGTGACTTGGAACAG
TTTTTCCGCAGCCTCTCGGCCACCACCCTCGTGAGTATGGGTGCCCTGGCTGCCATCCTT
GCCTACTGGTTCACTCAGCGGCCAAAGGCCTTGCAGCCGCCATGCAACCTCCTGATGCAG
TCAGAAGAAGTAGAGGACAGTGGCGGGGCACGGCGATCTGTGATTGGGTCTGGCCCTCAG
CTACTTACCCACTACTATGATGATGCCCGGACCATGTACCAGGTGTTCCGCCGTGGGCTT
AGCATCTCAGGGAATGGGCCCTGTCTTGGTTTCAGGAAGCCTAAGCAGCCTTACCAGTGG
CTGTCCTACCAGGAGGTGGCCGACAGGGCTGAATTTCTGGGGTCCGGACTTCTCCAGCAC
AATTGTAAAGCATGCACTGATCAGTTTATTGGTGTTTTTGCACAAAATCGGCCAGAGTGG
ATCATTGTGGAGCTGGCCTGCTACACATATTCCATGGTGGTGGTCCCGCTCTATGACACC
CTGGGCCCTGGGGCTATCCGCTACATCATCAATACAGCGGACATCAGCACCGTGATTGTG
GACAAACCTCAGAAGGCTGTGCTTCTGCTAGAGCATGTGGAGAGGAAGGAGACTCCAGGC
CTCAAGCTGATCATCCTCATGGACCCATTCGAAGAAGCCCTGAAAGAGAGAGGGCAGAAG
TGCGGGGTGGTCATTAAGTCCATGCAGGCCGTGGAGGACTGTGGCCAAGAGAATCACCAG
GCTCCTGTGCCCCCGCAGCCTGATGACCTCTCCATTGTGTGTTTCACAAGCGGCACGACA
GGGAACCCAAAAGGTGCGATGCTCACCCATGGGAACGTGGTGGCTGATTTCTCAGGCTTT
CTGAAAGTGACAGAGAGTCAGTGGGCTCCCACTTGTGCGGATGTGCACATTTCCTATTTG
CCTTTAGCACACATGTTTGAGCGAATGGTGCAGTCTGTCGTCTATTGCCACGGAGGGCGT
GTTGGCTTCTTCCAGGGAGATATCCGCCTTCTCTCAGATGACATGAAGGCTCTATGCCCC
ACCATCTTCCCTGTGGTCCCACGACTGCTGAACCGGATGTACGACAAGATCTTCAGCCAG
GCAAACACACCATTAAAGCGCTGGCTCCTGGAGTTTGCAGCAAAGCGTAAGCAAGCCGAG
GTCCGGAGTGGAATCATCAGGAATGATAGTATCTGGGATGAACTCTTCTTTAATAAGATT
CAGGCCAGTCTTGGTGGGTGTGTGCGGATGATTGTTACTGGAGCAGCCCCAGCATCACCA
ACAGTTCTGGGATTTCTCCGGGCAGCTCTAGGGTGCCAGGTTTATGAAGGTTATGGCCAA
ACTGAGTGCACAGCTGGATGTACCTTCACCACTCCTGGCGACTGGACCTCAGGGCACGTA
GGGGCGCCACTTCCCTGCAATCATATCAAGCTCGTTGATGTTGAGGAACTGAACTACTGG
GCCTGCAAAGGAGAGGGAGAGATATGTGTGAGAGGACCAAATGTGTTCAAAGGCTACTTG
AAAGATCCAGACAGGACGAAGGAGGCCCTGGACAGCGATGGCTGGCTTCACACTGGAGAC
ATCGGAAAATGGCTGCCGGCAGGAACTCTTAAAATTATTGATCGGAAAAAGCATATATTT
AAACTTGCTCAGGGAGAATATGTTGCACCCGAGAAGATTGAGAACATCTACATCCGGAGC
CAACCTGTGGCGCAAATCTATGTCCATGGGGACAGCTTAAAGGCCTTTTTGGTAGGCATT
GTTGTGCCTGACCCTGAAGTTATGCCCTCCTGGGCCCAGAAGAGAGGAATTGAAGGAACA
TATGCAGATCTCTGCACAAATAAGGATCTGAAGAAAGCCATTTTGGAAGATATGGTGAGG
TTAGGAAAAGAAAGTGGACTCCATTCTTTTGAGCAGGTTAAAGCCATTCACATCCATTCT
GACATGTTCTCAGTTCAAAATGGCTTGCTGACCCCAACACTAAAAGCTAAGAGACCTGAG
CTGAGAGAGTACTTCAAAAAACAAATAGAAGAGCTTTACTCAATCCCCATGTGA

# Metabolic_Enzyme_78_GenBank_ID_Gene:
AF129166

# Metabolic_Enzyme_78_Chromosome_Location:
Not Available

# Metabolic_Enzyme_78_Locus:
Not Available

# Metabolic_Enzyme_78_SNPs:
Not Available

# Metabolic_Enzyme_78_General_References:
10548543; 10502316; 10048485

# Metabolic_Enzyme_78_References:
Not Available

# Metabolic_Enzyme_79_ID:
5895

# Metabolic_Enzyme_79_Name:
Methionyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_79_Synonyms:
Methionine--tRNA ligase; MetRS

# Metabolic_Enzyme_79_Gene_Name:
MARS

# Metabolic_Enzyme_79_Protein_Sequence:
>MethionyltRNA synthetase, cytoplasmic
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRA
LTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTP
QQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQF
ITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWW
KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMF
VSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQ
QIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK


# Metabolic_Enzyme_79_Number_of_Residues:
900

# Metabolic_Enzyme_79_Molecular_Weight:
101117

# Metabolic_Enzyme_79_Theoretical_pI:
6.05

# Metabolic_Enzyme_79_GO_Classification:
>>>
Function:  methionine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  methionyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_79_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_79_Specific_Function:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

# Metabolic_Enzyme_79_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_79_Reaction:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)

# Metabolic_Enzyme_79_Pfam_Domain_Function:
PF00043:GST_C;
PF09334:tRNA-synt_1g;
PF00458:WHEP-TRS

# Metabolic_Enzyme_79_Signals:
None

# Metabolic_Enzyme_79_Transmembrane_Regions:
None

# Metabolic_Enzyme_79_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_79_EC_Link:
EC 6.1.1.10

# Metabolic_Enzyme_79_GenBank_ID_Protein:
1702932

# Metabolic_Enzyme_79_SwissProt_ID:
SYMC_HUMAN (P56192)

# Metabolic_Enzyme_79_swissprot_Name:
Not Available

# Metabolic_Enzyme_79_Genecard_id:
MARS

# Metabolic_Enzyme_79_Geneatlas_id:
MARS

# Metabolic_Enzyme_79_hgnc_id:
HGNC:6898

# Metabolic_Enzyme_79_PDB_ID:
Not Available

# Metabolic_Enzyme_79_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_79_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_79_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_79_Gene_Sequence:
>2703 bp
ATGAGACTGTTCGTGAGTGATGGCGTCCCGGGTTGCTTGCCGGTGCTGGCCGCCGCCGGG
AGAGCCCGGGGCAGAGCAGAGGTGCTGATCAGCACTGTAGGCCCGGAAGATTGTGTGGTC
CCGTTCCTGACCCGGCCTAAGGTCCCTGTCTTGCAGGTGGATAGCGGCAACTACCTCTTC
TCCACTAGTGCAATCTGCCGATATTTTTTTTTGTTATCTGGCTGGGAGCAAGATGACCTC
ACTAACCAGTGGCTGGAATGGGAAGCGACAGAGCTGCAGCCAGCTTTGTCTGCTCCCCTG
TACTATTTAGTGGTCCAAGGCAAGAAGGGGGAAGATGTTCTTGGTTCAGTGCGGAGAGCC
CTGACTCACATTGACCACAGCTTGAGTCGTCAGAACTGTCCTTTCCTGGCTGGGGAGACA
GAATCTCTAGCCGACATTGTTTTGTGGGGAGCCCAATACCCATTACTGCAAGATCCCGCC
TACCTCCCTGAGGAGCTGAGTGCCCTGCACAGCTGGTTCCAGACACTGAGTACCCAGGAA
CCATGTCAGCGAGCTGCAGAGACTGTACTGAAACAGCAAGGTGTCCTGGCTCTCCGGCCT
TACCTCCAAAAGCAGCCCCAGCCCAGCCCCGCTGAGGGAAGGGCTGTCACCAATGAGCCT
GAGGAGGAGGAGCTGGCTACCCTATCTGAGGAGGAGATTGCTATGGCTGTTACTGCTTGG
GAGAAGGGCCTAGAAAGTTTGCCCCCGCTGCGGCCCCAGCAGAATCCAGTGTTGCCTGTG
GCTGGAGAAAGGAATGTGCTCATCACCAGTGCCCTCCCTTACGTCAACAATGTCCCCCAC
CTTGGGAACATCATTGGTTGTGTGCTCAGTGCCGATGTCTTTGCCAGGTACTCTCGCCTC
CGCCAGTGGAACACCCTCTATCTGTGTGGGACAGATGAGTATGGTACAGCAACAGAGACC
AAGGCTCTGGAGGAGGGACTAACCCCCCAGGAGATCTGCGACAAGTACCACATCATCCAT
GCTGACATCTACCGCTGGTTTAACATTTCGTTTGATATTTTTGGTCGCACCACCACTCCA
CAGCAGACCAAAATCACCCAGGACATTTTCCAGCAGTTGCTGAAACGAGGTTTTGTGCTG
CAAGATACTGTGGAGCAACTGCGATGTGAGCACTGTGCTCGCTTCCTGGCTGACCGCTTC
GTGGAGGGCGTGTGTCCCTTCTGTGGCTATGAGGAGGCTCGGGGTGACCAGTGTGACAAG
TGTGGCAAGCTCATCAATGCTGTCGAGCTTAAGAAGCCTCAGTGTAAAGTCTGCCGATCA
TGCCCTGTGGTGCAGTCGAGCCAGCACCTGTTTCTGGACCTGCCTAAGCTGGAGAAGCGA
CTGGAGGAGTGGTTGGGGAGGACATTGCCTGGCAGTGACTGGACACCCAATGCCCAGTTT
ATCACCCGTTCTTGGCTTCGGGATGGCCTCAAGCCACGCTGCATAACCCGAGACCTCAAA
TGGGGAACCCCTGTACCCTTAGAAGGTTTTGAAGACAAGGTATTCTATGTCTGGTTTGAT
GCCACTATTGGCTATCTGTCCATCACAGCCAACTACACAGACCAGTGGGAGAGATGGTGG
AAGAACCCAGAGCAAGTGGACCTGTATCAGTTCATGGCCAAAGACAATGTTCCTTTCCAT
AGCTTAGTCTTTCCTTGCTCAGCCCTAGGAGCTGAGGATAACTATACCTTGGTCAGCCAC
CTCATTGCTACAGAGTACCTGAACTATGAGGATGGGAAATTCTCTAAGAGCCGCGGTGTG
GGAGTGTTTGGGGACATGGCCCAGGACACGGGGATCCCTGCTGACATCTGGCGCTTCTAT
CTGCTGTACATTCGGCCTGAGGGCCAGGACAGTGCTTTCTCCTGGACGGACCTGCTGCTG
AAGAATAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAACAGAGCTGGGATGTTT
GTGTCTAAGTTCTTTGGGGGCTATGTGCCTGAGATGGTGCTCACCCCTGATGATCAGCGC
CTGCTGGGCCATGTCACCCTGGAGCTCCAGCACTATCACCAGCTACTTGAGAAGGTTCGG
ATCCGGGATGCCTTGCGCAGTATCCTCACCATATCTCGACATGGCAACCAATATATTCAG
GTGAATGAGCCCTGGAAGCGGATTAAAGGCAGTGAGGCTGACAGGCAACGGGCAGGAACA
GTGACTGGCTTGGCAGTGAATATAGCTGCCTTGCTCTCTGTCATGCTTCAGCCTTACATG
CCCACGGTTAGTGCCACAATCCAGGCCCAGCTGCAGCTCCCACCTCCAGCCTGCAGTATC
CTGCTGACAAACTTCCTGTGTACCTTACCAGCAGGACACCAGATTGGCACAGTCAGTCCC
TTGTTCCAAAAATTGGAAAATGACCAGATTGAAAGTTTAAGGCAGCGCTTTGGAGGGGGC
CAGGCAAAAACGTCCCCGAAGCCAGCAGTTGTAGAGACTGTTACAACAGCCAAGCCACAG
CAGATACAAGCGCTGATGGATGAAGTGACAAAACAAGGAAACATTGTCCGAGAACTGAAA
GCACAAAAGGCAGACAAGAACGAGGTTGCTGCGGAGGTGGCGAAACTCTTGGATCTAAAG
AAACAGTTGGCTGTAGCTGAGGGGAAACCCCCTGAAGCCCCTAAAGGCAAGAAGAAAAAG
TAA

# Metabolic_Enzyme_79_GenBank_ID_Gene:
X94754

# Metabolic_Enzyme_79_Chromosome_Location:
Not Available

# Metabolic_Enzyme_79_Locus:
Not Available

# Metabolic_Enzyme_79_SNPs:
Not Available

# Metabolic_Enzyme_79_General_References:
8921912

# Metabolic_Enzyme_79_References:
Not Available

# Metabolic_Enzyme_80_ID:
5896

# Metabolic_Enzyme_80_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

# Metabolic_Enzyme_80_Synonyms:
GMP-PDE alpha; PDE V-B1

# Metabolic_Enzyme_80_Gene_Name:
PDE6A

# Metabolic_Enzyme_80_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit alpha
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKWYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ

# Metabolic_Enzyme_80_Number_of_Residues:
860

# Metabolic_Enzyme_80_Molecular_Weight:
99636

# Metabolic_Enzyme_80_Theoretical_pI:
5.48

# Metabolic_Enzyme_80_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_80_General_Function:
Not Available

# Metabolic_Enzyme_80_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal

# Metabolic_Enzyme_80_Pathway:
Not Available

# Metabolic_Enzyme_80_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_80_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_80_Signals:
None

# Metabolic_Enzyme_80_Transmembrane_Regions:
None

# Metabolic_Enzyme_80_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_80_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_80_GenBank_ID_Protein:
2366987

# Metabolic_Enzyme_80_SwissProt_ID:
PDE6A_HUMAN (P16499)

# Metabolic_Enzyme_80_swissprot_Name:
Not Available

# Metabolic_Enzyme_80_Genecard_id:
PDE6A

# Metabolic_Enzyme_80_Geneatlas_id:
PDE6A

# Metabolic_Enzyme_80_hgnc_id:
HGNC:8785

# Metabolic_Enzyme_80_PDB_ID:
Not Available

# Metabolic_Enzyme_80_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_80_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_80_Subcellular_Location:
Cell membrane; lipid-anchor; cytoplasmic side (Potential)

# Metabolic_Enzyme_80_Gene_Sequence:
>2583 bp
ATGGGCGAGGTGACAGCAGAGGAGGTGGAGAAGTTCCTGGACTCGAATATTGGCTTTGCC
AAACAGTACTACAACCTCCACTACCGGGCCAAGCTCATCTCCGACCTCCTTGGGGCCAAG
GAGGCTGCCGTGGACTTCAGCAACTACCACTCCCCGAGCAGCATGGAGGAGAGCGAAATC
ATCTTTGATCTCCTGCGGGACTTTCAGGAGAATTTACAGACAGAGAAATGCATCTTCAAT
GTCATGAAGAAGCTGTGCTTCCTCCTGCAGGCAGACCGCATGAGCCTGTTCATGTACCGG
ACCCGCAATGGCATCGCAGAGCTGGCCACCAGGCTTTTCAATGTCCACAAGGATGCTGTC
CTCGAGGACTGCCTGGTGATGCCCGACCAAGAGATCGTCTTCCCTTTGGACATGGGCATC
GTGGGCCATGTCGCACACTCTAAGAAGATTGCTAACGTCCCCAACACAGAGGAGGATGAG
CATTTCTGTGACTTTGTGGACATCCTCACAGAGTACAAGACCAAGAACATCTTGGCTTCC
CCCATAATGAATGGGAAGGATGTGGTGGCCATAATCATGGCTGTGAATAAAGTGGATGGA
TCCCACTTCACCAAGAGAGATGAAGAGATTCTTCTCAAGTACCTCAATTTTGCAAATCTA
ATCATGAAGTGGTACCACCTGAGTTACCTGCACAACTGTGAAACTCGACGTGGCCAGATA
CTGCTGTGGTCTGGGAGCAAAGTCTTTGAAGAACTTACGGACATCGAACGACAGTTCCAC
AAAGCCCTGTACACAGTCCGTGCTTTCCTCAACTGTGACAGATACTCTGTGGGTCTCTTA
GACATGACCAAGCAGAAGGAATTTTTTGATGTGTGGCCGGTTCTGATGGGTGAAGTTCCA
CCTTACTCTGGTCCCAGGACTCCGGATGGAAGAGAAATTAACTTTTACAAGGTCATTGAC
TACATCCTGCATGGCAAAGAGGACATCAAAGTCATCCCGAATCCACCTCCTGACCATTGG
GCTTTAGTAAGCGGTCTCCCCGCTTATGTTGCCCAGAATGGCCTGATTTGCAACATCATG
AACGCGCCTGCGGAGGACTTTTTTGCATTTCAGAAAGAACCTCTGGATGAGTCTGGATGG
ATGATTAAAAATGTGCTTTCAATGCCGATTGTGAACAAGAAGGAAGAAATTGTTGGAGTG
GCCACATTTTACAATCGTAAAGATGGGAAGCCCTTTGATGAAATGGATGAGACGCTCATG
GAGTCTTTGACTCAATTTCTGGGCTGGTCTGTCTTAAATCCTGACACCTATGAGTCAATG
AATAAACTTGAAAATAGGAAGGATATTTTCCAGGACATAGTAAAATATCATGTGAAGTGT
GACAATGAAGAAATTCAGAAAATCTTGAAAACCAGAGAGGTGTATGGGAAGGAGCCATGG
GAGTGTGAGGAAGAGGAGCTGGCTGAGATCCTGCAAGCGGAGCTGCCAGATGCAGATAAA
TACGAAATTAATAAATTTCACTTCAGTGACTTACCCCTAACAGAACTGGAGCTGGTAAAA
TGTGGAATACAGATGTATTATGAGCTCAAAGTGGTGGATAAATTTCACATTCCACAAGAG
GCCCTGGTGCGGTTCATGTACTCCCTGAGTAAGGGCTACCGCAAGATCACCTACCACAAC
TGGCGGCACGGCTTCAACGTGGGGCAGACCATGTTCTCCCTGCTGGTGACGGGAAAGCTG
AAGCGCTACTTCACGGACCTAGAGGCCTTGGCCATGGTCACTGCTGCTTTCTGCCATGAC
ATTGACCACAGAGGCACCAATAACCTCTACCAGATGAAATCCCAGAACCCACTGGCCAAG
CTCCATGGGTCCTCTATCTTGGAAAGACACCACTTGGAGTTTGGCAAAACACTGCTCAGA
GACGAGAGCCTGAATATCTTTCAAAACCTCAATCGTCGACAGCATGAGCATGCCATCCAC
ATGATGGACATTGCAATCATTGCCACAGACCTCGCCCTGTATTTCAAGAAGAGGACGATG
TTCCAAAAGATCGTGGATCAGTCTAAGACATATGAGAGTGAACAGGAGTGGACACAGTAC
ATGATGCTGGAGCAGACACGGAAGGAAATCGTTATGGCCATGATGATGACCGCCTGTGAT
CTCTCAGCCATCACCAAACCCTGGGAGGTGCAGAGCCAGGTAGCTCTGCTGGTGGCTGCT
GAATTCTGGGAACAAGGTGACCTGGAGCGCACGGTGCTGCAACAGAATCCCATTCCCATG
ATGGACAGAAACAAAGCAGATGAACTCCCTAAGCTTCAAGTCGGCTTCATTGACTTTGTT
TGCACCTTCGTCTACAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGAC
GGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGATG
AAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAAT
CAGCCGGGGGGAAACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAG
TAA

# Metabolic_Enzyme_80_GenBank_ID_Gene:
M26061

# Metabolic_Enzyme_80_Chromosome_Location:
Not Available

# Metabolic_Enzyme_80_Locus:
Not Available

# Metabolic_Enzyme_80_SNPs:
Not Available

# Metabolic_Enzyme_80_General_References:
2155175; 7493036

# Metabolic_Enzyme_80_References:
Not Available

# Metabolic_Enzyme_81_ID:
5897

# Metabolic_Enzyme_81_Name:
Alanyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_81_Synonyms:
Alanine--tRNA ligase; AlaRS; Renal carcinoma antigen NY-REN-42

# Metabolic_Enzyme_81_Gene_Name:
AARS

# Metabolic_Enzyme_81_Protein_Sequence:
>AlanyltRNA synthetase, cytoplasmic
MDSTLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPS
HPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALE
LLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGD
TGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDT
GMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLAD
HARTITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDA
FPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDSKTIPGDTAWLLYDTYGF
PVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEV
TDDSPKYNYHLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLDKTCFYAEQGG
QIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLFIDEPRRRP
IMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMI
EAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSV
EFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVMEAK
VKAQTAPNKDVQREIADLGEALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKR
VLEKTKQFIDSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKIT
CLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQ
LRLGDVKN

# Metabolic_Enzyme_81_Number_of_Residues:
968

# Metabolic_Enzyme_81_Molecular_Weight:
106812

# Metabolic_Enzyme_81_Theoretical_pI:
5.18

# Metabolic_Enzyme_81_GO_Classification:
>>>
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  alanine-tRNA ligase activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  alanyl-tRNA aminoacylation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_81_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_81_Specific_Function:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_81_Pathway:
map00252  Alanine and aspartate metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_81_Reaction:
ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)

# Metabolic_Enzyme_81_Pfam_Domain_Function:
PF02272:DHHA1;
PF01411:tRNA-synt_2c;
PF07973:tRNA_SAD

# Metabolic_Enzyme_81_Signals:
None

# Metabolic_Enzyme_81_Transmembrane_Regions:
None

# Metabolic_Enzyme_81_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_81_EC_Link:
EC 6.1.1.7

# Metabolic_Enzyme_81_GenBank_ID_Protein:
1015321

# Metabolic_Enzyme_81_SwissProt_ID:
SYAC_HUMAN (P49588)

# Metabolic_Enzyme_81_swissprot_Name:
Not Available

# Metabolic_Enzyme_81_Genecard_id:
AARS

# Metabolic_Enzyme_81_Geneatlas_id:
AARS

# Metabolic_Enzyme_81_hgnc_id:
HGNC:20

# Metabolic_Enzyme_81_PDB_ID:
Not Available

# Metabolic_Enzyme_81_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_81_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_81_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_81_Gene_Sequence:
>2907 bp
ATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAGCGATTTATAGATTTCTTCAAGAGG
AACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTC
TTTGCCAATGCAGGCATGAACCAGTTTAAACCCATTTTCCTGAACACAATTGACCCATCT
CACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACCCAGAAGTGCATCCGGGCTGGGGGC
AAACAAAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATG
CTGGGCTCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAA
CTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGACTTTATGTTACTTACTTTGGCGGG
GATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGGG
CTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGAC
ACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTACGACCGGATTGGTGGTCGGGACGCC
GCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATC
CAGTATAACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACA
GGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAGAATAAGATGTCCAACTATGACACT
GACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATACACT
GGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGAC
CATGCTCGGACCATCACTGTGGCACTGGCTGATGGTGGCCGGCCTGACAACACAGGGCGT
GGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAAT
GCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCA
TTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAGGACATCATTAATGAAGAAGAGGTG
CAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTG
GGAGACAGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTT
CCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAGGGCCTGGTGGTAGACATGGATGGC
TTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGGGAA
GACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTC
ACAGATGATTCCCCAAAGTACAATTACCATTTGGACTCCAGTGGTAGCTATGTATTTGAG
AACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCC
ACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGC
CAGATCTATGACGAAGGCTACCTGGTGAAGGTGGATGACAGCAGTGAAGATAAAACAGAG
TTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTAC
GGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCC
ATCATGAGCAACCACACAGCTACGCACATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGG
GAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCC
AAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATT
GAGGCAGCCAAGGCCGTCTATACCCAGGATTGCCCCCTGGCAGCAGCGAAAGCCATCCAG
GGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGG
GTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTT
GAGTTCTGTGGGGGAACGCACCTGCGGAACTCGAGTCATGCAGGAGCTTTTGTGATCGTG
ACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCC
CAGAAGGCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAA
GTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAGAGGGAGATCGCTGACCTTGGAGAG
GCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAAGGATGAATTGCGGGAGACTCTCAAA
TCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGA
GTGTTAGAGAAGACGAAGCAGTTCATCGACAGCAACCCCAACCAGCCTCTTGTCATCCTG
GAGATGGAGAGCGGCGCCTCAGCCAAGGCCCTGAATGAAGCCTTGAAGCTCTTCAAGATG
CACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACG
TGCCTGTGTCAAGTCCCCCAGAATGCAGCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTG
CAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGGTGGCAAGGATGTGTCTGCACAGGCC
ACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAG
CTGCGCCTCGGGGATGTAAAGAACTGA

# Metabolic_Enzyme_81_GenBank_ID_Gene:
D32050

# Metabolic_Enzyme_81_Chromosome_Location:
Not Available

# Metabolic_Enzyme_81_Locus:
Not Available

# Metabolic_Enzyme_81_SNPs:
Not Available

# Metabolic_Enzyme_81_General_References:
7654687; 10508479

# Metabolic_Enzyme_81_References:
Not Available

# Metabolic_Enzyme_82_ID:
5898

# Metabolic_Enzyme_82_Name:
Tryptophanyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_82_Synonyms:
Tryptophan--tRNA ligase; TrpRS; (MtTrpRS

# Metabolic_Enzyme_82_Gene_Name:
WARS2

# Metabolic_Enzyme_82_Protein_Sequence:
>TryptophanyltRNA synthetase, mitochondrial precursor
MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWV
RLQDEYDSVLYSIVDLHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEH
TQLSWILSCMVRLPRLQHLHQWKAKTTKQKHDGTVGLLTYPVLQAADILLYKSTHVPVGE
DQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSAKMSKSDPDKLATVRI
TDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA
RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL


# Metabolic_Enzyme_82_Number_of_Residues:
360

# Metabolic_Enzyme_82_Molecular_Weight:
40147

# Metabolic_Enzyme_82_Theoretical_pI:
9.82

# Metabolic_Enzyme_82_GO_Classification:
>>>
Function:  tryptophan-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  tryptophanyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_82_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_82_Specific_Function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_82_Pathway:
map00380  Tryptophan metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_82_Reaction:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

# Metabolic_Enzyme_82_Pfam_Domain_Function:
PF00579:tRNA-synt_1b

# Metabolic_Enzyme_82_Signals:
None

# Metabolic_Enzyme_82_Transmembrane_Regions:
None

# Metabolic_Enzyme_82_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_82_EC_Link:
EC 6.1.1.2

# Metabolic_Enzyme_82_GenBank_ID_Protein:
6572289

# Metabolic_Enzyme_82_SwissProt_ID:
SYWM_HUMAN (Q9UGM6)

# Metabolic_Enzyme_82_swissprot_Name:
Not Available

# Metabolic_Enzyme_82_Genecard_id:
WARS2

# Metabolic_Enzyme_82_Geneatlas_id:
WARS2

# Metabolic_Enzyme_82_hgnc_id:
HGNC:12730

# Metabolic_Enzyme_82_PDB_ID:
Not Available

# Metabolic_Enzyme_82_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_82_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_82_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_82_Gene_Sequence:
>1083 bp
ATGGCGCTGCACTCAATGCGGAAAGCGCGTGAGCGCTGGAGCTTCATCCGGGCACTTCAT
AAGGGATCCGCAGCTGCTCCCGCTCTCCAGAAAGACAGCAAGAAGCGAGTATTTTCCGGC
ATTCAACCTACAGGAATCCTCCACCTGGGCAATTACCTGGGAGCCATTGAGAGCTGGGTG
AGGTTACAGGATGAATATGACTCTGTATTATACAGCATTGTTGACCTCCACTCCATTACT
GTCCCCCAAGACCCAGCTGTCCTTCGGCAGAGCATCCTGGACATGACTGCTGTTCTTCTT
GCCTGTGGCATAAACCCGGAAAAAAGCATCCTTTTCCAACAATCTCAGGTGTCTGAACAC
ACACAATTAAGTTGGATCCTTTCCTGCATGGTCAGACTACCTCGATTACAACATTTACAT
CAGTGGAAGGCAAAGACTACCAAGCAGAAGCACGATGGCACGGTGGGCCTGCTCACATAC
CCAGTACTCCAGGCAGCCGACATTCTGTTGTACAAGTCCACACACGTTCCTGTTGGGGAG
GATCAAGTCCAGCACATGGAACTAGTTCAGGATCTAGCACAAGGTTTCAACAAGAAGTAT
GGGGAGTTCTTTCCAGTGCCCGAGTCCATTCTCACATCCATGAAGAAGGTAAAATCCCTA
CGTGATCCTTCTGCCAAAATGTCGAAATCAGACCCTGACAAACTGGCCACCGTCCGAATA
ACAGACAGCCCAGAGGAGATAGTGCAGAAATTCCGCAAGGCTGTGACAGACTTCACCTCG
GAGGTCACCTATGACCCGGCTGGCCGCGCTGGCGTGTCCAACATAGTGGCGGTGCATGCC
GCGGTGACGGGGCTCTCCGTGGAGGAAGTGGTGCGCCGCAGCGCGGGCATGAACACTGCT
CGCTACAAGCTGGCCGTGGCAGATGCTGTGATTGAGAAGTTTGCCCCAATTAAGCGTGAA
ATTGAAAAACTGAAGCTGGACAAGGACCATTTAGAGAAGGTTTTACAAATTGGATCAGCA
AAAGCCAAAGAATTAGCATACACTGTGTGCCAGGAGGTGAAGAAATTGGTGGGTTTTCTA
TAG

# Metabolic_Enzyme_82_GenBank_ID_Gene:
AJ242739

# Metabolic_Enzyme_82_Chromosome_Location:
Not Available

# Metabolic_Enzyme_82_Locus:
Not Available

# Metabolic_Enzyme_82_SNPs:
Not Available

# Metabolic_Enzyme_82_General_References:
10828066

# Metabolic_Enzyme_82_References:
Not Available

# Metabolic_Enzyme_83_ID:
5899

# Metabolic_Enzyme_83_Name:
ADP-sugar pyrophosphatase

# Metabolic_Enzyme_83_Synonyms:
Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; YSA1H

# Metabolic_Enzyme_83_Gene_Name:
NUDT5

# Metabolic_Enzyme_83_Protein_Sequence:
>ADPsugar pyrophosphatase
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTAD
GVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYK
GDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQ
RLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF

# Metabolic_Enzyme_83_Number_of_Residues:
219

# Metabolic_Enzyme_83_Molecular_Weight:
24328

# Metabolic_Enzyme_83_Theoretical_pI:
4.59

# Metabolic_Enzyme_83_GO_Classification:
Not Available

# Metabolic_Enzyme_83_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_83_Specific_Function:
Hydrolyzes with similar activities ADP-ribose, ADP- mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity

# Metabolic_Enzyme_83_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_83_Reaction:
ADP-ribose + H2O = AMP + D-ribose 5-phosphate

# Metabolic_Enzyme_83_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_83_Signals:
None

# Metabolic_Enzyme_83_Transmembrane_Regions:
None

# Metabolic_Enzyme_83_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_83_EC_Link:
EC 3.6.1.13

# Metabolic_Enzyme_83_GenBank_ID_Protein:
6288769

# Metabolic_Enzyme_83_SwissProt_ID:
NUDT5_HUMAN (Q9UKK9)

# Metabolic_Enzyme_83_swissprot_Name:
Not Available

# Metabolic_Enzyme_83_Genecard_id:
NUDT5

# Metabolic_Enzyme_83_Geneatlas_id:
NUDT5

# Metabolic_Enzyme_83_hgnc_id:
HGNC:8052

# Metabolic_Enzyme_83_PDB_ID:
Not Available

# Metabolic_Enzyme_83_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_83_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_83_Subcellular_Location:
Not Available

# Metabolic_Enzyme_83_Gene_Sequence:
>660 bp
ATGGAGAGCCAAGAACCAACGGAATCTTCTCAGAATGGCAAACAGTATATCATTTCAGAG
GAGTTAATTTCAGAAGGAAAATGGGTCAAGCTTGAAAAAACAACGTACATGGATCCTACT
GGTAAAACTAGAACTTGGGAATCAGTGAAACGTACAACCAGGAAAGAGCAGACTGCGGAT
GGTGTCGCGGTCATCCCCGTGCTGCAGAGAACACTTCACTATGAGTGTATCGTTCTGGTG
AAACAGTTCCGACCACCAATGGGGGGCTACTGCATAGAGTTCCCTGCAGGTCTCATAGAT
GATGGTGAAACCCCAGAAGCAGCTGCTCTCCGGGAGCTTGAAGAAGAAACTGGCTACAAA
GGGGACATTGCCGAATGTTCTCCAGCGGTCTGTATGGACCCAGGCTTGTCAAACTGTACT
ATACACATCGTGACAGTCACCATTAACGGAGATGATGCCGAAAACGCAAGGCCGAAGCCA
AAGCCAGGGGATGGAGAGTTTGTGGAAGTCATTTCTTTACCCAAGAATGACCTGCTGCAG
AGACTTGATGCTCTGGTAGCTGAAGAACATCTCACAGTGGACGCCAGGGTCTATTCCTAC
GCTCTAGCGCTGAAACATGCAAATGCAAAGCCATTTGAAGTGCCCTTCTTGAAATTTTAA


# Metabolic_Enzyme_83_GenBank_ID_Gene:
AF155832

# Metabolic_Enzyme_83_Chromosome_Location:
Not Available

# Metabolic_Enzyme_83_Locus:
Not Available

# Metabolic_Enzyme_83_SNPs:
Not Available

# Metabolic_Enzyme_83_General_References:
10567213; 10722730; 11042152

# Metabolic_Enzyme_83_References:
Not Available

# Metabolic_Enzyme_84_ID:
5900

# Metabolic_Enzyme_84_Name:
Ribose-phosphate pyrophosphokinase I

# Metabolic_Enzyme_84_Synonyms:
Phosphoribosyl pyrophosphate synthetase I; PRS-I; PPRibP

# Metabolic_Enzyme_84_Gene_Name:
PRPS1

# Metabolic_Enzyme_84_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IMPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSG
CGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVA
GADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVT
SIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSA
GATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEA
IRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_84_Number_of_Residues:
318

# Metabolic_Enzyme_84_Molecular_Weight:
34835

# Metabolic_Enzyme_84_Theoretical_pI:
6.98

# Metabolic_Enzyme_84_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_84_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_84_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_84_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_84_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_84_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_84_Signals:
None

# Metabolic_Enzyme_84_Transmembrane_Regions:
None

# Metabolic_Enzyme_84_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_84_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_84_GenBank_ID_Protein:
35702

# Metabolic_Enzyme_84_SwissProt_ID:
PRPS1_HUMAN (P60891)

# Metabolic_Enzyme_84_swissprot_Name:
Not Available

# Metabolic_Enzyme_84_Genecard_id:
PRPS1

# Metabolic_Enzyme_84_Geneatlas_id:
PRPS1

# Metabolic_Enzyme_84_hgnc_id:
HGNC:9462

# Metabolic_Enzyme_84_PDB_ID:
Not Available

# Metabolic_Enzyme_84_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_84_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_84_Subcellular_Location:
Not Available

# Metabolic_Enzyme_84_Gene_Sequence:
>957 bp
ATGCCGAATATCAAAATCTTCAGCGGCAGTTCCCACCAGGACTTATCTCAGAAAATTGCT
GACCGCCTGGGCCTGGAGCTAGGCAAGGTGGTGACTAAGAAGTTCAGCAACCAGGAGACC
TGTGTGGAAATCGGTGAAAGTGTACGTGGAGAGGATGTCTACATTGTTCAGAGTGGTTGT
GGCGAAATCAATGACAATTTAATGGAGCTTTTGATCATGATTAATGCCTGCAAGATTGCT
TCAGCCAGCCGGGTTACTGCAGTCATCCCATGCTTCCCTTATGCCCGGCAGGATAAGAAG
GATAAGAGCCGGGCGCCAATCTCAGCCAAGCTTGTTGCAAATATGCTATCTGTAGCAGGT
GCAGATCATATTATCACCATGGACCTACATGCTTCTCAAATTCAGGGCTTTTTTGATATC
CCAGTAGACAATTTGTATGCAGAGCCGGCTGTCCTAAAGTGGATAAGGGAGAATATCTCT
GAGTGGAGGAACTGCACTATTGTCTCACCTGATGCTGGTGGAGCTAAGAGAGTGACCTCC
ATTGCAGACAGGCTGAATGTGGACTTTGCCTTGATTCACAAAGAACGGAAGAAGGCCAAT
GAAGTGGACCGCATGGTGCTTGTGGGAGATGTGAAGGATCGGGTGGCCATCCTTGTGGAT
GACATGGCTGACACTTGTGGCACAATCTGCCATGCAGCTGACAAACTTCTCTCAGCTGGC
GCCACCAGAGTTTATGCCATCTTGACTCATGGAATCTTCTCCGGTCCTGCTATTTCTCGC
ATCAACAACGCATGCTTTGAGGCAGTAGTAGTCACCAATACCATACCTCAGGAGGACAAG
ATGAAGCATTGCTCCAAAATACAGGTGATTGACATCTCTATGATCCTTGCAGAAGCCATC
AGGAGAACTCACAATGGAGAATCCGTTTCTTACCTATTCAGCCATGTCCCTTTATAA

# Metabolic_Enzyme_84_GenBank_ID_Gene:
X15331

# Metabolic_Enzyme_84_Chromosome_Location:
Not Available

# Metabolic_Enzyme_84_Locus:
Not Available

# Metabolic_Enzyme_84_SNPs:
Not Available

# Metabolic_Enzyme_84_General_References:
2155397; 1650777; 1314091; 7593598

# Metabolic_Enzyme_84_References:
Not Available

# Metabolic_Enzyme_85_ID:
5901

# Metabolic_Enzyme_85_Name:
Seryl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_85_Synonyms:
Seryl- tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRSmt

# Metabolic_Enzyme_85_Gene_Name:
SARS2

# Metabolic_Enzyme_85_Protein_Sequence:
>SeryltRNA synthetase, mitochondrial precursor
MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS

# Metabolic_Enzyme_85_Number_of_Residues:
518

# Metabolic_Enzyme_85_Molecular_Weight:
58283

# Metabolic_Enzyme_85_Theoretical_pI:
8.22

# Metabolic_Enzyme_85_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_85_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_85_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_85_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_85_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_85_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_85_Signals:
1-24

# Metabolic_Enzyme_85_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_85_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_85_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_85_GenBank_ID_Protein:
9188535

# Metabolic_Enzyme_85_SwissProt_ID:
SYSM_HUMAN (Q9NP81)

# Metabolic_Enzyme_85_swissprot_Name:
Not Available

# Metabolic_Enzyme_85_Genecard_id:
SARS2

# Metabolic_Enzyme_85_Geneatlas_id:
SARS2

# Metabolic_Enzyme_85_hgnc_id:
HGNC:17697

# Metabolic_Enzyme_85_PDB_ID:
Not Available

# Metabolic_Enzyme_85_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_85_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_85_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_85_Gene_Sequence:
>1557 bp
ATGGCTGCGTCCATGGCGCGGCGCTTGTGGCCTTTGCTGACTCGTCGGGGGTTCCGGCCC
CGGGGAGGCTGCATCTCCAACGATAGTCCAAGGAGAAGTTTCACTACAGAGAAACGAAAC
CGGAACCTCCTGTACGAGTATGCGCGCGAGGGCTACAGCGCACTCCCTCAGCTGGACATA
GAGCGGTTCTGCGCATGCCCAGAAGAGGCCGCACACGCCCTGGAGCTCCGCAAGGGGGAG
CTGCGCTCGGCGGACCTGCCCGCGATCATCTCGACATGGCAGGAGCTGAGGCAGCTGCAG
GAGCAGATCCGGAGCCTGGAGGAAGAGAAGGCAGCTGTGACTGAGGCAGTGCGGGCCCTG
CTGGCAAACCAGGACAGTGGTGAAGTGCAGCAGGACCCCAAGTACCAGGGTCTGCGGGCA
CGTGGCCGGGAGATCCGGAAGGAGCTTGTTCACCTGTACCCCAGGGAGGCCCAGCTTGAG
GAGCAGTTCTACCTGCAGGCGCTGAAGCTGCCCAACCAGACCCACCCAGACGTGCCCGTC
GGGGATGAGAGCCAGGCTCGAGTGCTCCACATGGTCGGAGACAAGCCAGTTTTCTCCTTC
CAACCTCGGGGCCACCTGGAAATTGGCGAGAAACTCGACATCATCCGTCAGAAGCGCCTG
TCCCACGTGTCTGGCCACCGGTCCTATTACCTGCGCGGGGCTGGAGCCCTCCTGCAGCAC
GGCCTGGTCAACTTCACATTCAACAAGCTTCTCCGCCGGGGCTTCACCCCCATGACGGTG
CCAGACCTTCTCCGCGGAGCAGTGTTTGAAGGCTGTGGGATGACACCAAATGCCAACCCA
TCCCAAATTTACAACATCGACCCTGCCCGCTTCAAAGATCTCAACCTGGCTGGAACAGCG
GAGGTGGGGCTTGCAGGCTACTTCATGGACCACACCGTGGCCTTCAGGGACCTGCCAGTC
AGGATGGTTTGCTCCAGCACCTGCTACCGGGCAGAGACAAACACGGGACAGGAACCCCGG
GGGCTGTATCGAGTACACCACTTCACCAAGGTGGAGATGTTTGGGGTGACAGGCCCTGGG
CTGGAGCAGAGCTCACAGCTGCTGGAGGAGTTCCTGTCCCTTCAGATGGAGATCTTGACA
GAGCTGGGCTTGCACTTCCGGGTCCTGGATATGCCCACCCAAGAACTGGGCCTCCCCGCC
TACCGCAAGTTTGACATTGAGGCCTGGATGCCAGGCCGAGGCCGCTTTGGAGAGGTCACC
AGTGCTTCCAACTGCACAGACTTCCAGAGCCGCCGCCTCCACATCATGTTCCAGACCGAG
GCTGGGGAGCTGCAGTTTGCCCACACGGTGAACGCCACCGCCTGTGCTGTCCCCCGCCTT
CTCATCGCGCTCCTGGAGAGTAACCAGCAGAAGGACGGCTCAGTGCTCGTGCCCCCTGCC
CTCCAGTCCTACCTCGGCACTGATCGGATCACAGCCCCTACCCACGTGCCTCTCCAGTAC
ATCGGCCCCAACCAGCCCCGGAAGCCTGGGCTGCCTGGCCAGCCTGCTGTAAGCTAA

# Metabolic_Enzyme_85_GenBank_ID_Gene:
AB029948

# Metabolic_Enzyme_85_Chromosome_Location:
Not Available

# Metabolic_Enzyme_85_Locus:
Not Available

# Metabolic_Enzyme_85_SNPs:
Not Available

# Metabolic_Enzyme_85_General_References:
10764807

# Metabolic_Enzyme_85_References:
Not Available

# Metabolic_Enzyme_86_ID:
5902

# Metabolic_Enzyme_86_Name:
High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

# Metabolic_Enzyme_86_Synonyms:
HSPDE8B

# Metabolic_Enzyme_86_Gene_Name:
PDE8B

# Metabolic_Enzyme_86_Protein_Sequence:
>Highaffinity cAMPspecific and IBMXinsensitive 3',5'cyclic phosphodiesterase 8
BMGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRAS
GPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAE
VRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEI
IVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFM
ENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFE
RMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHV
KITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESID
VKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVL
EILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPIT
INDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRA
WFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDH
PGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQA
IIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC
ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY
FITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS

# Metabolic_Enzyme_86_Number_of_Residues:
885

# Metabolic_Enzyme_86_Molecular_Weight:
98980

# Metabolic_Enzyme_86_Theoretical_pI:
6.81

# Metabolic_Enzyme_86_GO_Classification:
>>>
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
Function:  two-component response regulator activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  signal transducer activity
Function:  catalytic activity
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
Process:  two-component signal transduction system (phosphorelay)
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_86_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_86_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase has high affinity for cAMP and may be involved in specific signaling in the thyroid gland

# Metabolic_Enzyme_86_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_86_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_86_Pfam_Domain_Function:
PF00989:PAS;
PF08629:PDE8;
PF00233:PDEase_I;
PF00072:Response_reg

# Metabolic_Enzyme_86_Signals:
None

# Metabolic_Enzyme_86_Transmembrane_Regions:
None

# Metabolic_Enzyme_86_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_86_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_86_GenBank_ID_Protein:
32261241

# Metabolic_Enzyme_86_SwissProt_ID:
PDE8B_HUMAN (O95263)

# Metabolic_Enzyme_86_swissprot_Name:
Not Available

# Metabolic_Enzyme_86_Genecard_id:
PDE8B

# Metabolic_Enzyme_86_Geneatlas_id:
PDE8B

# Metabolic_Enzyme_86_hgnc_id:
HGNC:8794

# Metabolic_Enzyme_86_PDB_ID:
Not Available

# Metabolic_Enzyme_86_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_86_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_86_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_86_Gene_Sequence:
>2517 bp
ATGGGCTGCGCCCCCAGCATCCATGTCTCGCAGAGCGGCGTGATCTACTGCCGGGACTCG
GACGAGTCCAGCTCGCCCCGCCAGACCACCAGCGTGTCGCAGGGCCCGGCGGCACCCCTG
CCCGGCCTCTTCGTCCAGACCGACGCCGCCGACGCCATCCCCCCGAGCCGCGCGTCGGGA
CCCCCCAGCGTAGCCCGCGTCCGCAGGGCCCGCACCGAGCTGGGCAGCGGTAGCAGCGCG
GGTTCCGCAGCCCCCGCCGCGACCACCAGCAGGGGCCGGAGGCGCCACTGCTGCAGCAGC
GCCGAGGCCGAGACTCAGACCTGCTACACCAGCGTGAAGCAGGTGTCTTCTGCGGAGGTG
CGCATCGGGCCCATGAGACTGACGCAGGACCCTATTCAGGTTTTGCTGATCTTTGCAAAG
GAAGATAGTCAGAGCGATGGCTTCTGGTGGGCCTGCGACAGAGCTGGTTATAGATGCAAT
ATTGCTCGGACTCCAGAGTCAGCCCTTGAATGCTTTCTTGATAAGCATCATGAAATTATT
GTAATTGATCATAGACAAACTCAGAACTTCGATGCAGAAGCAGTGTGCAGGTCGATCCGG
GCCACAAATCCCTCCGAGCACACGGTGATCCTCGCAGTGGTTTCGCGAGTATCGGATGAC
CATGAAGAGGCGTCAGTCCTTCCTCTTCTCCACGCAGGCTTCAACAGGAGATTTATGGAG
AATAGCAGCATAATTGCTTGCTATAATGAACTGATTCAAATAGAACATGGGGAAGTTCGC
TCCCAGTTCAAATTACGGGCCTGTAATTCAGTGTTTACAGCATTAGATCACTGTCATGAA
GCCATAGAAATAACAAGCGATGACCACGTGATTCAGGAGTGGCAGGGGGTTTACTATGCC
AGACGGAAATCCGGGGACAGCATCCAACAGCACGTGAAGATCACCCCAGTGATTGGCCAA
GGAGGGAAAATTAGGCATTTTGTCTCGCTCAAGAAACTGTGTTGTACCACTGACAATAAT
AAGCAGATTCACAAGATTCATCGTGATTCAGGAGATAATTCTCAGACAGAGCCTCATTCA
TTCAGATATAAGAACAGGAGGAAAGAGTCCATTGACGTGAAATCGATATCATCTCGAGGC
AGTGATGCACCAAGCCTGCAGAATCGTCGCTATCCGTCCATGGCGAGGATCCACTCCATG
ACCATCGAGGCTCCCATCACAAAGGTTATAAATATAATCAATGCAGCCCAAGAAAACAGC
CCAGTCACAGTAGCGGAAGCCTTGGACAGAGTTCTAGAGATTTTACGGACCACAGAACTG
TACTCCCCTCAGCTGGGTACCAAAGATGAAGATCCCCACACCAGTGATCTTGTTGGAGGC
CTGATGACTGACGGCTTGAGAAGACTGTCAGGAAACGAGTATGTGTTTACTAAGAATGTG
CACCAGAGTCACAGTCACCTTGCAATGCCAATAACCATCAATGATGTTCCCCCTTGTATC
TCTCAATTACTTGATAATGAGGAGAGTTGGGACTTCAACATCTTTGAATTGGAAGCCATT
ACGCATAAAAGGCCATTGGTTTATCTGGGCTTAAAGGTCTTCTCTCGGTTTGGAGTATGT
GAGTTTTTAAACTGTTCTGAAACCACTCTTCGGGCCTGGTTCCAAGTGATCGAAGCCAAC
TACCACTCTTCCAATGCCTACCACAACTCCACCCATGCTGCCGACGTCCTGCACGCCACC
GCTTTCTTTCTTGGAAAGGAAAGAGTAAAGGGAAGCCTCGATCAGTTGGATGAGGTGGCA
GCCCTCATTGCTGCCACAGTCCATGACGTGGATCACCCGGGAAGGACCAACTCTTTCCTC
TGCAATGCAGGCAGTGAGCTTGCTGTGCTCTACAATGACACTGCTGTTCTGGAGAGTCAC
CACACCGCCCTGGCCTTCCAGCTCACGGTCAAGGACACCAAATGCAACATTTTCAAGAAT
ATTGACAGGAACCATTATCGAACGCTGCGCCAGGCTATTATTGACATGGTTTTGGCAACA
GAGATGACAAAACACTTTGAACATGTGAATAAGTTTGTGAACAGCATCAACAAGCCAATG
GCAGCTGAGATTGAAGGCAGCGACTGTGAATGCAACCCTGCTGGGAAGAACTTCCCTGAA
AACCAAATCCTGATCAAACGCATGATGATTAAGTGTGCTGACGTGGCCAACCCATGCCGC
CCCTTGGACCTGTGCATTGAATGGGCTGGGAGGATCTCTGAGGAGTATTTTGCACAGACT
GATGAAGAGAAGAGACAGGGACTACCTGTGGTGATGCCAGTGTTTGACCGGAATACCTGT
AGCATCCCCAAGTCTCAGATCTCTTTCATTGACTACTTCATAACAGACATGTTTGATGCT
TGGGATGCCTTTGCACATCTACCAGCCCTGATGCAACATTTGGCTGACAACTACAAACAC
TGGAAGACACTAGATGACCTAAAGTGCAAAAGTTTGAGGCTTCCATCTGACAGCTAA

# Metabolic_Enzyme_86_GenBank_ID_Gene:
AY129948

# Metabolic_Enzyme_86_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_86_Locus:
5q14.1

# Metabolic_Enzyme_86_SNPs:
rs335614; rs971647; rs40594; rs459366; rs1061405; rs3733953; rs460267; rs16874261; rs832790; rs1479564; rs2046045; rs1479594; rs1479563; rs251421; rs335605; rs335643; rs844274; rs335644; rs875214; rs1531615; rs832788; rs832787; rs1904441; rs141331; rs890717; rs251420; rs2242159; rs884162; rs1096752; rs832785; rs251419; rs1479600; rs1871467; rs10473990; rs3797462; rs6867654; rs3733952; rs1545774; rs7715119; rs7717046; rs12697864; rs10056404; rs9686527; rs12521494; rs163017; rs11739402; rs4704402; rs1382879; rs7720828; rs6863296; rs922540; rs11960749; rs6887019; rs4704403; rs10066037; rs1560024; rs6885282; rs335599; rs1479598; rs6885813; rs335640; rs6860843; rs4704410; rs1382893; rs6893108; rs6453304; rs1479565; rs10942816; rs6874493; rs10474498; rs7717216; rs251426; rs12523314; rs374003; rs12516568; rs4704412; rs6864050; rs2242160; rs6453298; rs6453305; rs11953611; rs7729842; rs7732963; rs7714529; rs7705337; rs251418; rs922539; rs181851; rs4704417; rs4704397; rs12697863; rs6864358; rs7731628; rs7727976; rs11738226; rs1124742; rs11949597; rs13160107; rs3101867; rs1382894; rs1545775; rs10064824; rs2359877; rs7728597; rs4704414; rs10036386; rs251422; rs2279095; rs7733908; rs6860674; rs6453299; rs251416; rs1479562; rs6885099; rs10061629; rs10066802; rs10942819; rs4704409; rs12187512; rs10942817; rs16874184; rs7703993; rs7707719; rs951275; rs90684; rs11951639; rs335638; rs11956168; rs3816609; rs9293713; rs4704408; rs9686526; rs10213867; rs17683162; rs11738541; rs7718685; rs6453302; rs12520862; rs10474500; rs17570409; rs6886144; rs9687206; rs11745130; rs11738313; rs7702192; rs2359875; rs16874127; rs2859576; rs4704399; rs16874252; rs13436203; rs2359876; rs11747913; rs6453303; rs398509; rs251425; rs10942815; rs10514095; rs11744930; rs6453300; rs1982661; rs4704411; rs2359797; rs7723920; rs13355167; rs181852; rs6453296; rs11738417; rs11750528; rs2619770; rs6887671; rs6884413; rs16874241; rs11742966; rs7719378; rs11741219; rs10514096; rs970114; rs6892518; rs9687030; rs11957189; rs4596357; rs11742730; rs4704400; rs17671296; rs11959854; rs13158658; rs2306344; rs9942368; rs3101866; rs11748011; rs12515504; rs13361710; rs11749728; rs4704416; rs6861787; rs10045589; rs7448368; rs11748861; rs1479596; rs11741458; rs13164603; rs723374; rs335597; rs11749079; rs13178853; rs2884816; rs2359874; rs2306345; rs13158164; rs4703730; rs7713259; rs10514098; rs12514694; rs12515498; rs7716880; rs1479567; rs251428; rs10076794; rs10474493; rs1351283; rs335598; rs1479597; rs11750342; rs6453297; rs251414; rs2242161; rs1351284; rs11750661; rs11950697; rs251429; rs11956845; rs10514099; rs13182395; rs2046046; rs4703731; rs2061909; rs2359872; rs12522076; rs6896093; rs17750669; rs7711488; rs12513677; rs335618; rs90682; rs9686502; rs11750710; rs251430; rs7706106; rs1962690; rs90683; rs1479595; rs17671243; rs2170021; rs11741983; rs7704000; rs6870257; rs335616; rs6873924; rs989758; rs10037599; rs10069775; rs12658216; rs6862335; rs251417; rs13159632; rs7732150; rs12516965; rs6453301; rs6881121; rs12514649; rs12188039; rs864109; rs11949070; rs1993945; rs335642; rs13179491; rs1871466; rs183142; rs13186963; rs17683175; rs12658665; rs12189200; rs13179191; rs7710193; rs6871774; rs12652928; rs1479601; rs6881859; rs1993946; rs410656; rs13167306; rs13186807; rs6897771; rs11738860; rs9293711; rs16874254; rs4470750; rs10474499; rs11742634; rs6882455; rs2279094; rs35317395; rs7723017; rs16874217; rs4703732; rs6884627; rs11955381; rs13183278; rs16874125; rs2127387; rs10942818; rs11958816; rs16874147; rs1479599; rs6887282; rs9293716; rs9293712; rs4704398; rs13166933; rs13179196; rs6859326; rs10085063; rs3214046; rs7724067; rs10045594; rs17570416; rs6875758; rs10037785; rs7724077; rs2359873; rs16874198; rs6877581; rs11744847; rs17750729; rs2011799; rs7721608; rs4704401; rs6453295; rs13180935; rs10043551; rs9784696; rs251427; rs13186178; rs12515919; rs11749959; rs10474497; rs11741955; rs251413; rs11740409; rs12188903; rs6867719; rs13356848; rs7702923; rs2306343; rs16874239; rs7702029; rs6870261; rs7710509; rs13163022; rs173706; rs12188035; rs7719566; rs10474496; rs4704413; rs251431; rs7726487; rs17570031; rs1971620; rs6897909; rs13182285; rs6883526; rs6888919; rs17671405; rs6866018; rs6865817; rs13159287; rs7726243; rs335615; rs16874258; rs395882; rs17671389; rs12514448; rs10055027; rs10474495; rs13167302; rs6870862; rs10074631; rs13436637; rs12655629; rs6879904; rs17750688; rs6896812; rs10038311; rs10805909; rs11748016; rs335639; rs3816608; rs384871; rs7710224; rs10474494; rs7709849; rs12519528; rs186753; rs10536220; rs35454325; rs3733956; rs3733954; rs3733955; rs2017194; rs35747735; rs13163675; rs35577468; rs12153049; rs7714995; rs4704404; rs7735605; rs34790629; rs28409208; rs34299034; rs5868866; rs7714678; rs10039955; rs35428698; rs35884509; rs11745026; rs10474501; rs4432867; rs35554951; rs989759; rs10589971; rs36123024; rs35500936; rs1075970; rs13179037; rs11342716; rs251423; rs33976034; rs34191327; rs12233968; rs10474491; rs35235250; rs10591556; rs36022309; rs34566085; rs6858922; rs4704405; rs3926515; rs4521449; rs10608700; rs35742497; rs34717093; rs7717513; rs35601934; rs34988409; rs12520774; rs34128451; rs35350477; rs35358557; rs35681195; rs35858417; rs7714055; rs28622161; rs12515456; rs7356782; rs10085113; rs251424; rs35094296; rs1678771; rs36015907; rs34047268; rs17570395; rs11294329; rs34098762; rs34208297; rs3217712; rs34818611; rs34990832; rs3031820; rs33948936; rs34014902; rs34156142; rs5868864; rs34885670; rs34414970; rs35345614; rs11395504; rs16874135; rs12153424; rs11429258; rs35966684; rs13179071; rs6892493; rs28681499; rs3031818; rs28710929; rs35022674; rs34802194; rs11746782; rs11295108; rs35070029; rs11351004; rs35116180; rs34537187; rs34646527; rs1678770; rs35065656; rs1479566; rs34923412; rs10053760; rs35315780; rs35794220; rs11959580; rs34650604; rs33989497; rs10538529; rs5868867; rs35232100; rs35318083; rs2127393; rs35382869; rs34744319; rs2011227; rs34891839; rs335641; rs34698234; rs11316141; rs34336462; rs34713301; rs992807; rs11291697; rs10570712; rs34595584; rs335620; rs34465374; rs35914326; rs2359798; rs35785414; rs11284931; rs28431869; rs35786402; rs35981544; rs10552319; rs34318585; rs35164635; rs36052225; rs28527260; rs35776739; rs34491745; rs35910383; rs34720163; rs12521742; rs10645799; rs6860861; rs2306342; rs35407074; rs33938742; rs9687054; rs35870926; rs34731275; rs6871708; rs335617; rs7726528; rs41361846; rs35749456; rs34999521; rs28684701; rs35812985; rs1479568; rs13176017; rs34047237; rs35330679; rs35596621; rs6883469; rs35327743; rs13184182; rs5868865; rs3101235; rs6888937; rs34079916; rs35814560; rs35864749; rs10054725; rs3087185; rs34282242; rs6866209; rs34721887; rs13170449; rs34215321; rs6873097; rs35635069; rs33982217; rs832789; rs6875032; rs34708007; rs6894516; rs35839801; rs35156526; rs11422456; rs10036431; rs34725176; rs11418983; rs35535651; rs34142462; rs989757; rs36012253; rs35049636; rs34634450; rs6884434; rs35105712; rs34161143; rs4704406; rs11351800; rs33935667; rs3101236; rs34478659; rs34868740; rs34295093; rs11750129; rs35571993; rs173705; rs36011566; rs13158646; rs34152352; rs13179039; rs10076967; rs35309506; rs5868868; rs34081668; rs35776933; rs36021489; rs10589970; rs35120441; rs34017471; rs13159463; rs13174807; rs35159916; rs35280028; rs11405343; rs10602643; rs10573022; rs34410098; rs7443262; rs35717428; rs34922408; rs34773470; rs13158363; rs34420432; rs35470878; rs951276; rs35287095; rs34667262; rs251415; rs13170957; rs3031840; rs35452272; rs5868861; rs13166828; rs11958889; rs35160422; rs6866832; rs10710933; rs5868863; rs4704407; rs10552320; rs34684475; rs34735760; rs34540880; rs13166832; rs34008487; rs34960472; rs35010340; rs17671075; rs35522982; rs12523516; rs6884022; rs35185692; rs35363643; rs34748700; rs11413850; rs3031815; rs35838065; rs36085912; rs34764404; rs34648561; rs10639131; rs35674495; rs9942364; rs36120983; rs13166110; rs953375; rs35689253; rs34089667; rs13183146; rs5868860; rs7730446; rs5868862; rs13179043; rs35262504; rs35174935; rs12523538; rs35201094; rs35997618; rs35295164; rs35798710; rs35028488; rs35515495; rs35812799; rs9763156; rs2884817; rs4133658; rs2619784; rs34034632; rs34093656; rs35449293; rs13178574; rs34937443; rs35968667; rs335619; rs12110072; rs34525889; rs35052848; rs1045094; rs1111991; rs11739698; rs12652987; rs1382880; rs14368; rs1580; rs16874264; rs17671842; rs1982658; rs1982659; rs2114950; rs251411; rs251412; rs2928173; rs2972333; rs2972336; rs3149; rs335621; rs335622; rs335623; rs335624; rs335625; rs335627; rs335628; rs335629; rs335630; rs335631; rs335632; rs335633; rs335634; rs335635; rs335636; rs34489686; rs35189891; rs35774719; rs3797461; rs3797632; rs3797633; rs3797634; rs4704396; rs4704421; rs6864606; rs6891339; rs6898325; rs7726419; rs7737666; rs922538; rs972629; rs974280

# Metabolic_Enzyme_86_General_References:
12372422; 12681444; 9784418

# Metabolic_Enzyme_86_References:
Not Available

# Metabolic_Enzyme_87_ID:
5903

# Metabolic_Enzyme_87_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C

# Metabolic_Enzyme_87_Synonyms:
DPDE1; PDE21

# Metabolic_Enzyme_87_Gene_Name:
PDE4C

# Metabolic_Enzyme_87_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
CMENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRER
DLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRES
FLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLG
AAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKR
ILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHS
ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL
LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL
AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN
LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ
NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG
FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFE
LTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT

# Metabolic_Enzyme_87_Number_of_Residues:
712

# Metabolic_Enzyme_87_Molecular_Weight:
79902

# Metabolic_Enzyme_87_Theoretical_pI:
4.84

# Metabolic_Enzyme_87_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_87_General_Function:
Not Available

# Metabolic_Enzyme_87_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_87_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_87_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_87_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_87_Signals:
None

# Metabolic_Enzyme_87_Transmembrane_Regions:
None

# Metabolic_Enzyme_87_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_87_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_87_GenBank_ID_Protein:
727223

# Metabolic_Enzyme_87_SwissProt_ID:
PDE4C_HUMAN (Q08493)

# Metabolic_Enzyme_87_swissprot_Name:
Not Available

# Metabolic_Enzyme_87_Genecard_id:
PDE4C

# Metabolic_Enzyme_87_Geneatlas_id:
PDE4C

# Metabolic_Enzyme_87_hgnc_id:
HGNC:8782

# Metabolic_Enzyme_87_PDB_ID:
Not Available

# Metabolic_Enzyme_87_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_87_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_87_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_87_Gene_Sequence:
>2139 bp
ATGGAGAACCTGGGGGTCGGCGAAGGGGCAGAGGCTTGCAGCAGGTTGAGTCGCTCTCGC
GGCCGCCACAGCATGACCAGAGCCCCGAAGCACCTGTGGCGGCAACCCCGGCGCCCCATC
CGCATCCAACAGCGCTTCTATTCGGATCCGGACAAGTCCGCGGGCTGCCGCGAGAGGGAC
CTGAGCCCGCGGCCGGAGCTCAGGAAGTCGCGGCTCTCCTGGCCCGTTTCCTCCTGCAGG
CGCTTTGACCTGGAAAATGGGCTCTCGTGTGGGAGGAGGGCCCTGGACCCTCAGTCCAGC
CCTGGCCTGGGCCGGATTATGCAGGCTCCAGTCCCGCACAGCCAGCGGCGCGAGTCCTTC
CTGTACCGCTCAGATAGCGACTATGAACTCTCGCCCAAGGCCATGTCTCGGAACTCCTCT
GTGGCCAGCGACCTACATGGAGAGGACATGATTGTGACGCCCTTTGCCCAGGTCCTGGCC
AGTCTGCGGACCGTTCGGAGCAACGTGGCGGCCCTTGCCCGCCAGCAATGCCTAGGAGCA
GCCAAGCAGGGACCCGTCGGAAACCCTTCATCCAGCAATCAGCTCCCTCCTGCAGAGGAC
ACGGGGCAGAAGCTGGCATTGGAGACGCTAGACGAGCTGGACTGGTGCCTGGATCAGTTG
GAGACGCTGCAGACCCGGCACTCGGTGGGGGAGATGGCCTCCAACAAGTTCAAGCGGATC
CTGAACCGGGAGTTGACCCACCTGTCCGAAACCAGCCGCTCCGGGAACCAGGTGTCCGAG
TACATCTCCCGGACCTTCCTGGACCAGCAGACCGAGGTGGAGCTGCCCAAGGTGACCGCT
GAGGAGGCCCCACAGCCCATGTCCCGGATCAGTGGCCTACATGGGCTCTGCCACAGTGCC
AGCCTCTCCTCAGCCACTGTCCCACGCTTTGGGGTCCAGACTGACCAGGAGGAGCAACTG
GCCAAGGAGCTAGAAGACACCAACAAGTGGGGACTTGATGTGTTCAAGGTGGCGGACGTA
AGTGGGAACCGGCCCCTCACAGCTATCATATTCAGCATTTTTCAGGAGCGGGACCTGCTG
AAGACATTCCAGATCCCAGCAGACACACTGGCCACCTACCTGCTGATGCTGGAGGGTCAC
TACCACGCCAATGTGGCCTACCACAACAGCCTACATGCCGCCGACGTGGCCCAGTCCACG
CATGTGCTGCTGGCTACGCCCGCCCTCGAGGCTGTGTTCACAGACTTGGAAATCCTGGCT
GCCCTCTTTGCAAGCGCCATCCACGACGTGGACCATCCTGGGGTCTCCAACCAGTTTCTG
ATTAACACCAACTCAGACGTGGCGCTTATGTACAACGACGCCTCGGTGCTGGAGAACCAT
CACCTGGCTGTGGGCTTCAAGCTGCTGCAGGCAGAGAACTGCGATATCTTCCAGAACCTC
AGCGCCAAGCAGCGACTGAGTCTGCGCAGGATGGTCATTGACATGGTGCTGGCCACAGAC
ATGTCCAAACACATGAACCTCCTGGCCGACCTCAAGACCATGGTGGAGACCAAGAAGGTG
ACAAGCCTCGGTGTCCTCCTCCTGGACAACTATTCCGACCGAATCCAGGTCTTGCAGAAC
CTGGTGCACTGTGCTGATCTGAGCAACCCCACCAAGCCGCTGCCCCTGTACCGCCAGTGG
ACGGACCGCATCATGGCCGAGTTCTTCCAGCAGGGAGACCGCGAGCGTGAGTCGGGCCTG
GACATCAGTCCCATGTGTGACAAGCATACGGCCTCAGTGGAGAAGTCCCAGGTGGGTTTC
ATTGACTACATTGCTCACCCACTGTGGGAGACTTGGGCTGACCTGGTCCACCCAGATGCA
CAGGACCTGCTGGACACGCTGGAGGACAATCGAGAGTGGTACCAGAGCAAGATCCCCCGA
AGTCCCTCAGACCTCACCAACCCCGAGCGGGACGGGCCTGACAGATTCCAGTTTGAACTG
ACTCTGGAGGAGGCAGAGGAAGAGGATGAGGAGGAAGAAGAGGAGGGGGAAGAGACAGCT
TTAGCCAAAGAGGCCTTGGAGTTGCCTGACACTGAACTCCTGTCCCCTGAAGCCGGCCCA
GACCCTGGGGACTTACCCCTCGACAACCAGAGGACTTAG

# Metabolic_Enzyme_87_GenBank_ID_Gene:
Z46632

# Metabolic_Enzyme_87_Chromosome_Location:
Not Available

# Metabolic_Enzyme_87_Locus:
Not Available

# Metabolic_Enzyme_87_SNPs:
Not Available

# Metabolic_Enzyme_87_General_References:
7843419; 10574328; 8413254

# Metabolic_Enzyme_87_References:
Not Available

# Metabolic_Enzyme_88_ID:
5904

# Metabolic_Enzyme_88_Name:
Ribose-phosphate pyrophosphokinase II

# Metabolic_Enzyme_88_Synonyms:
Phosphoribosyl pyrophosphate synthetase II; PRS-II; PPRibP

# Metabolic_Enzyme_88_Gene_Name:
PRPS2

# Metabolic_Enzyme_88_Protein_Sequence:
>Ribosephosphate pyrophosphokinase 
IIMPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQS
GCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSV
AGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRV
TSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLS
AGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAE
AIRRTHNGESVSYLFSHVPL

# Metabolic_Enzyme_88_Number_of_Residues:
318

# Metabolic_Enzyme_88_Molecular_Weight:
34770

# Metabolic_Enzyme_88_Theoretical_pI:
6.60

# Metabolic_Enzyme_88_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  lipoate-protein ligase activity
Function:  lipoate-protein ligase B activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  diphosphotransferase activity
Function:  ribose phosphate diphosphokinase activity
 ||
>>>
Process:  nucleotide biosynthesis
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleoside monophosphate metabolism
Process:  nucleoside monophosphate biosynthesis
Process:  ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_88_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_88_Specific_Function:
ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_88_Pathway:
map00030  Pentose phosphate pathway;
 map00230  Purine metabolism

# Metabolic_Enzyme_88_Reaction:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_88_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_88_Signals:
None

# Metabolic_Enzyme_88_Transmembrane_Regions:
None

# Metabolic_Enzyme_88_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_88_EC_Link:
EC 2.7.6.1

# Metabolic_Enzyme_88_GenBank_ID_Protein:
35700

# Metabolic_Enzyme_88_SwissProt_ID:
PRPS2_HUMAN (P11908)

# Metabolic_Enzyme_88_swissprot_Name:
Not Available

# Metabolic_Enzyme_88_Genecard_id:
PRPS2

# Metabolic_Enzyme_88_Geneatlas_id:
PRPS2

# Metabolic_Enzyme_88_hgnc_id:
HGNC:9465

# Metabolic_Enzyme_88_PDB_ID:
Not Available

# Metabolic_Enzyme_88_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_88_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_88_Subcellular_Location:
Not Available

# Metabolic_Enzyme_88_Gene_Sequence:
>957 bp
ATGCCCAACATCGTGCTGTTCAGCGGCAGCTCGCATCAGGACCTATCCCAGCGCGTGGCC
GACCGCCTGGGCCTGGAGCTGGGCAAGGTGGTCACGAAGAAGTTCAGCAACCAGGAGACC
AGCGTGGAGATTGGTGAAAGCGTGAGAGGGGAAGATGTCTACATCATCCAGAGCGGCTGC
GGGGAAATTAACGACAACCTGATGGAACTCCTCATCATGATCAATGCCTGCAAGATTGCG
TCATCATCCAGAGTAACTGCCGTGATCCCGTGTTTCCCATACGCCCGACAAGATAAAAAG
GACAAGAGTCGTGCCCCAATTTCTGCAAAACTTGTGGCCAATATGCTGTCGGTGGCTGGG
GCGGATCACATCATCACCATGGACCTGCATGCTTCTCAGATACAGGGATTCTTTGATATT
CCTGTGGATAATTTGTATGCGGAGCCCGCAGTCCTGCAGTGGATTCGGGAAAACATTGCC
GAGTGGAAGAACTGTATCATTGTTTCACCTGACGCAGGGGGAGCCAAAAGGGTTACATCA
ATTGCAGACAGGTTGAATGTGGAATTTGCTTTGATCCACAAAGAGAGGAAGAAGGCGAAT
GAAGTGGACCGGATGGTCCTGGTGGGCGACGTGAAGGACCGTGTGGCCATCCTCGTGGAT
GACATGGCTGACACTTGCGGCACCATCTGCCATGCTGCGGACAAGCTGCTGTCAGCTGGA
GCCACCAAAGTGTATGCTATCCTTACCCATGGGATCTTCTCTGGACCAGCTATTTCCAGA
ATAAATAATGCCGCCTTTGAGGCTGTTGTCGTCACAAACACAATTCCGCAAGAGGACAAA
ATGAAACACTGCACCAAGATTCAGGTCATTGACATTTCCATGATCTTGGCCGAAGCAATC
CGAAGGACACACAATGGGGAATCCGTGTCCTACCTGTTCAGCCATGTCCCGCTATAA

# Metabolic_Enzyme_88_GenBank_ID_Gene:
Y00971

# Metabolic_Enzyme_88_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_88_Locus:
Xp22.3-p22.2

# Metabolic_Enzyme_88_SNPs:
rs1731469; rs2239490; rs917580; rs1638614; rs7062536; rs1266347; rs4830803; rs1638616; rs2284110; rs2239489; rs5935399; rs1266348; rs1731463; rs1269016; rs1731460; rs5979742; rs3815366; rs1638615; rs6639224; rs2699997; rs5979739; rs5934038; rs1632295; rs10521629; rs6639223; rs1638617; rs5979741; rs17281523; rs12558125; rs1731468; rs2284108; rs6641111; rs1638619; rs6641108; rs764646; rs2267489; rs2284106; rs12008243; rs7881129; rs6641109; rs2267488; rs4639691; rs16998972; rs2284105; rs7878770; rs4118335; rs1638613; rs17256004; rs2284102; rs5935397; rs6639222; rs2284101; rs7892586; rs1638612; rs1731470; rs11542625; rs11542626; rs1062629; rs16998976; rs6641113; rs41304713; rs5978578; rs7059565; rs12836621; rs2407939; rs10559509; rs12690195; rs5901489; rs34145657; rs5979740; rs1627037; rs35240522; rs12689006; rs7059902; rs2897808; rs2407938; rs10643414; rs1266349; rs3216443; rs5978580; rs2284104; rs12687586; rs6641101; rs35158521; rs12854516; rs36065243; rs5979737; rs7050147; rs6641100; rs41305175; rs6641102; rs10126562; rs7055278; rs6654965; rs2302266; rs2284109; rs5978579; rs7892044; rs35045468; rs5979738; rs34239644; rs35450855; rs3932785; rs12862297; rs12396877; rs12116138; rs41311801; rs34397079; rs1266365; rs1406788; rs1638607; rs1638608; rs1638610; rs1731471; rs1731474; rs1731475; rs17328218; rs2162; rs5934039; rs5979734; rs5979744; rs5979746; rs5979748; rs6641115; rs6641116

# Metabolic_Enzyme_88_General_References:
2538352; 2560337; 1314091

# Metabolic_Enzyme_88_References:
Not Available

# Metabolic_Enzyme_89_ID:
5266

# Metabolic_Enzyme_89_Name:
Acetyl-coenzyme A synthetase, cytoplasmic

# Metabolic_Enzyme_89_Synonyms:
Acetate--CoA ligase; Acyl-activating enzyme; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2

# Metabolic_Enzyme_89_Gene_Name:
ACSS2

# Metabolic_Enzyme_89_Protein_Sequence:
>Acetylcoenzyme A synthetase, cytoplasmic
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ

# Metabolic_Enzyme_89_Number_of_Residues:
701

# Metabolic_Enzyme_89_Molecular_Weight:
78580

# Metabolic_Enzyme_89_Theoretical_pI:
6.43

# Metabolic_Enzyme_89_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_89_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_89_Specific_Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation

# Metabolic_Enzyme_89_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_89_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_89_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_89_Signals:
None

# Metabolic_Enzyme_89_Transmembrane_Regions:
None

# Metabolic_Enzyme_89_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_89_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_89_GenBank_ID_Protein:
8439651

# Metabolic_Enzyme_89_SwissProt_ID:
ACSA_HUMAN (Q9NR19)

# Metabolic_Enzyme_89_swissprot_Name:
Not Available

# Metabolic_Enzyme_89_Genecard_id:
ACSS2

# Metabolic_Enzyme_89_Geneatlas_id:
ACSS2

# Metabolic_Enzyme_89_hgnc_id:
HGNC:15814

# Metabolic_Enzyme_89_PDB_ID:
Not Available

# Metabolic_Enzyme_89_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_89_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_89_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_89_Gene_Sequence:
>2106 bp
ATGGGGCTTCCTGAGGAGCGGGTCCGGAGCGGCAGCGGGAGCCGGGGCCAGGAGGAAGCT
GGAGCCGGAGGCCGGGCGCGGAGTTGGTCTCCGCCGCCCGAGGTCAGCCGCTCCGCGCAC
GTCCCCTCGCTGCAGCGCTACCGCGAGCTGCACCGGCGCTCCGTGGAGGAGCCGCGGGAA
TTCTGGGGAGACATTGCCAAGGAATTTTACTGGAAGACTCCATGCCCTGGCCCATTCCTT
CGGTACAACTTTGATGTGACTAAAGGGAAAATCTTCATTGAGTGGATGAAAGGAGCAACT
ACCAACATCTGCTACAATGTACTGGATCGAAATGTCCATGAGAAAAAGCTTGGAGATAAA
GTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACTCAGATCACATACCATCAG
CTTCTGGTCCAAGTGTGTCAGTTCAGCAATGTTCTCCGAAAACAGGGCATTCAGAAGGGG
GACCGAGTGGCCATCTACATGCCTATGATCCCAGAGCTTGTGGTGGCCATGCTGGCATGT
GCCCGCATTGGGGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTTCAGAGTCTCTATGT
GAACGGATCTTGGATTCCAGCTGCAGTCTTCTCATCACTACAGATGCCTTCTACAGGGGG
GAAAAGCTTGTGAACCTGAAGGAGCTGGCTGACGAGGCCCTGCAGAAGTGTCAGGAGAAG
GGTTTCCCAGTAAGATGCTGCATTGTGGTCAAGCACCTGGGGCGGGCAGAGCTCGGCATG
GGTGACTCCACCAGCCAGTCCCCCCCAATTAAGAGGTCATGCCCAGATGTGCAGATCTCA
TGGAACCAAGGGATTGACTTGTGGTGGCATGAGCTCATGCAAGAGGCAGGGGATGAGTGT
GAGCCCGAGTGGTGTGATGCCGAGGACCCACTCTTCATCCTGTACACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTTCACACAGTTGGGGGCTACATGCTCTATGTAGCCACAACC
TTCAAGTATGTGTTTGACTTCCATGCAGAGGATGTGTTCTGGTGCACGGCAGACATTGGT
TGGATCACTGGTCATTCCTACGTCACCTATGGGCCACTGGCCAATGGTGCCACCAGTGTT
TTGTTTGAGGGGATTCCCACATATCCGGACGTGAACCGCCTGTGGAGCATTGTGGACAAA
TACAAGGTGACCAAGTTCTACACAGCACCCACAGCCATCCGTCTGCTCATGAAGTTTGGA
GATGAGCCTGTCACCAAGCATAGCCGGGCATCCTTGCAGGTGTTAGGCACAGTGGGTGAA
CCCATCAACCCTGAGGCCTGGCTATGGTACCACCGGGTGGTAGGTGCCCAGCGCTGCCCC
ATCGTGGACACCTTCTGGCAAACAGAGACAGGTGGCCACATGTTGACTCCCCTTCCTGGT
GCCACACCCATGAAACCCGGTTCTGCTACTTTCCCATTCTTTGGTGTAGCTCCTGCAATC
CTGAATGAGTCCGGGGAAGAGTTGGAAGGTGAAGCTGAAGGTTATCTGGTGTTCAAGCAG
CCCTGGCCAGGGATCATGCGCACAGTCTATGGGAACCACGAACGCTTTGAGACAACCTAC
TTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGCTGCCAGCGGGACCAGGATGGC
TATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGT
ACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTG
GGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGC
CACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGG
AAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATG
TCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATC
CAGTGA

# Metabolic_Enzyme_89_GenBank_ID_Gene:
AF263614

# Metabolic_Enzyme_89_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_89_Locus:
20q11.22

# Metabolic_Enzyme_89_SNPs:
rs4911163; rs10485507; rs6120750; rs1013677; rs6088635; rs6579198; rs6058135; rs6087642; rs6087641; rs6088638; rs6088636; rs7509557; rs6088650; rs6087644; rs6120758; rs4911164; rs6060112; rs8119110; rs6120763; rs6087649; rs6058137; rs3746450; rs4911447; rs6088640; rs1060615; rs6119542; rs926734; rs8116657; rs4911451; rs6119543; rs6120757; rs4911449; rs6088646; rs2295097; rs6087643; rs2223881; rs6088642; rs8117380; rs2273683; rs8123210; rs11905770; rs2064454; rs2076667; rs12717838; rs3818273; rs3787215; rs2207147; rs6120754; rs4911450; rs7266550; rs4911448; rs2378294; rs8125240; rs2378291; rs17092174; rs2378292; rs6058142; rs6120756; rs3787214; rs6120753; rs17092163; rs17092169; rs6060107; rs6060113; rs2378293; rs8117491; rs6120759; rs6088647; rs17850882; rs6088649; rs4349415; rs13043365; rs2295096; rs34527271; rs13043347; rs35779501; rs3053923; rs35596631; rs6088637; rs8115733; rs7509556; rs2024634; rs11476807; rs6060105; rs11472785; rs2024633; rs11467604; rs6120749; rs35991119; rs1062891; rs2024632; rs11167247; rs17400522; rs11699241; rs11472114; rs36077883; rs13042631; rs34362920; rs35104294; rs6119540; rs11478163; rs6088651; rs2295095; rs9547; rs11299664; rs6142261; rs35620674; rs35540450; rs6060111; rs3054612; rs6120752; rs11479533; rs34171408; rs11425079; rs6142260; rs34872018; rs11697404; rs11481649; rs7268774; rs34951413; rs33930398; rs6087647; rs34277751; rs6119544; rs35456894; rs6120764; rs6087646; rs11476381; rs11479477; rs28878236; rs6142263; rs6058143; rs5841186; rs28802941; rs8119835; rs6058136; rs3054610; rs6120755; rs28434523; rs35234476; rs8184664; rs11474295; rs35208311; rs34525778; rs36108141; rs34213461; rs6142258; rs2378290; rs6088639; rs6060110; rs6088643; rs36102262; rs11699164; rs35470839; rs35962008; rs6142259; rs11421679; rs10542624; rs8183627; rs6142255; rs34682859; rs35504652; rs11474981; rs6060106; rs6060115; rs35655449; rs34939273; rs11482260; rs4588263; rs34590082; rs13038710; rs6120760; rs6058138; rs6058139; rs35212956; rs35067244; rs6088645; rs6060108; rs11483997; rs11477769; rs4600736; rs7260994; rs6142256; rs11479348; rs6120761; rs6141520; rs6087645; rs13044142; rs34680118; rs11481648; rs35773172; rs13339938; rs36019966; rs35404681; rs6142257; rs13038395; rs13040750; rs5841185; rs34109099; rs35829893; rs34032248; rs13041047; rs11476265; rs41287074; rs11469541; rs6088641; rs35102137; rs6142254; rs34578238; rs10554596; rs34807244; rs6119541; rs28694099; rs34675937; rs34401220; rs6120751; rs35359973; rs6060109; rs6060104; rs17309872; rs2064453; rs2236270; rs2236271; rs6060103; rs6087651; rs6088628; rs6088629; rs6088631; rs6088652; rs725521; rs7263157; rs7264920; rs7265109; rs7265992; rs7269682

# Metabolic_Enzyme_89_General_References:
10843999; 11780052

# Metabolic_Enzyme_89_References:
Not Available

# Metabolic_Enzyme_90_ID:
5905

# Metabolic_Enzyme_90_Name:
Thiamin pyrophosphokinase 1

# Metabolic_Enzyme_90_Synonyms:
Thiamine pyrophosphokinase 1; hTPK1; Placental protein 20; PP20

# Metabolic_Enzyme_90_Gene_Name:
TPK1

# Metabolic_Enzyme_90_Protein_Sequence:
>Thiamin pyrophosphokinase 1
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGER
ESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVD
VIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEG
DWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKS

# Metabolic_Enzyme_90_Number_of_Residues:
243

# Metabolic_Enzyme_90_Molecular_Weight:
27266

# Metabolic_Enzyme_90_Theoretical_pI:
4.82

# Metabolic_Enzyme_90_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  thiamin diphosphokinase activity
 ||
>>>
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  thiamin diphosphate biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  vitamin metabolism
Process:  water-soluble vitamin metabolism
Process:  thiamin and derivative metabolism
Process:  thiamin metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_90_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_90_Specific_Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate

# Metabolic_Enzyme_90_Pathway:
map00730  Thiamine metabolism

# Metabolic_Enzyme_90_Reaction:
ATP + thiamine = AMP + thiamine diphosphate

# Metabolic_Enzyme_90_Pfam_Domain_Function:
PF04265:TPK_B1_binding;
PF04263:TPK_catalytic

# Metabolic_Enzyme_90_Signals:
None

# Metabolic_Enzyme_90_Transmembrane_Regions:
None

# Metabolic_Enzyme_90_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_90_EC_Link:
EC 2.7.6.2

# Metabolic_Enzyme_90_GenBank_ID_Protein:
12248915

# Metabolic_Enzyme_90_SwissProt_ID:
TPK1_HUMAN (Q9H3S4)

# Metabolic_Enzyme_90_swissprot_Name:
Not Available

# Metabolic_Enzyme_90_Genecard_id:
TPK1

# Metabolic_Enzyme_90_Geneatlas_id:
TPK1

# Metabolic_Enzyme_90_hgnc_id:
HGNC:17358

# Metabolic_Enzyme_90_PDB_ID:
1IG3

# Metabolic_Enzyme_90_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_90_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_90_Subcellular_Location:
Not Available

# Metabolic_Enzyme_90_Gene_Sequence:
>732 bp
ATGGAGCATGCCTTTACCCCGTTGGAGCCCCTGCTTTCCACTGGGAATTTGAAGTACTGC
CTTGTAATTCTTAATCAGCCTTTGGACAACTATTTTCGTCATCTTTGGAACAAAGCTCTT
TTAAGAGCCTGTGCCGATGGAGGTGCCAACCGCTTATATGATATCACCGAAGGAGAGAGA
GAAAGCTTTTTGCCTGAATTCATCAATGGAGACTTTGATTCTATTAGGCCTGAAGTCAGA
GAATACTATGCTACTAAGGGATGTGAGCTCATTTCAACTCCTGATCAAGACCACACTGAC
TTTACTAAGTGCCTTAAAATGCTCCAAAAGAAGATAGAAGAAAAAGACTTAAAGGTTGAT
GTGATCGTGACACTGGGAGGCCTTGCTGGGCGTTTTGACCAGATTATGGCATCTGTGAAT
ACCTTGTTCCAAGCGACTCACATCACTCCTTTTCCAATTATAATAATCCAAGAGGAATCG
CTGATCTACCTGCTCCAACCAGGAAAGCACAGGTTGCATGTAGACACTGGAATGGAGGGT
GATTGGTGTGGCCTTATTCCTGTTGGACAGCCTTGTATGCAGGTTACAACCACAGGCCTC
AAGTGGAACCTCACAAATGATGTGCTTGCTTTTGGAACATTGGTCAGTACTTCCAATACC
TACGACGGGTCTGGTGTTGTGACTGTGGAAACTGACCACCCACTCCTCTGGACCATGGCC
ATCAAAAGCTAA

# Metabolic_Enzyme_90_GenBank_ID_Gene:
AB028138

# Metabolic_Enzyme_90_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_90_Locus:
7q34-q35

# Metabolic_Enzyme_90_SNPs:
rs1731108; rs726068; rs228582; rs1731095; rs1635363; rs2371549; rs41242; rs969356; rs1731096; rs714429; rs1860265; rs994418; rs41244; rs1476612; rs1406720; rs1987569; rs228581; rs2057868; rs1406719; rs228587; rs1635357; rs962779; rs1635359; rs1629687; rs1731119; rs40228; rs1621146; rs2056811; rs1731098; rs6464587; rs6979902; rs1612172; rs7788824; rs1635349; rs6953870; rs7778973; rs765811; rs6464609; rs41238; rs10250170; rs12535171; rs7810658; rs6976763; rs2371551; rs11981245; rs7781839; rs6961123; rs1731114; rs6963694; rs10085379; rs7807524; rs228578; rs4563807; rs6464610; rs7805109; rs41241; rs7802389; rs10265577; rs11983652; rs2189529; rs4726716; rs6946827; rs6959326; rs10952584; rs4141299; rs6960462; rs10276866; rs886469; rs6973206; rs6958347; rs1635354; rs9640426; rs41237; rs6973145; rs6949066; rs6464592; rs6464603; rs1635355; rs1635352; rs41243; rs5000945; rs7793227; rs7785647; rs7791540; rs10275875; rs6464588; rs6946690; rs6964237; rs10231525; rs721492; rs1406717; rs10247371; rs2371550; rs11972593; rs7804157; rs1406721; rs1731091; rs7792485; rs10233851; rs1625341; rs1074710; rs10272083; rs12703604; rs6965642; rs6464602; rs6464607; rs10231147; rs1622877; rs6464595; rs10249863; rs1635344; rs6954594; rs10952581; rs7455032; rs2158370; rs228584; rs6946166; rs7788339; rs6951723; rs6464598; rs7779534; rs11772094; rs1731101; rs10261806; rs6973390; rs10248004; rs1320822; rs757387; rs10257572; rs1731109; rs6954373; rs10952579; rs7807442; rs6951849; rs717885; rs7805061; rs6464608; rs7793033; rs6966303; rs4725658; rs4726707; rs6948399; rs1731105; rs2888075; rs6974629; rs10268309; rs7806323; rs11980724; rs6967455; rs7803486; rs6942497; rs2040898; rs1476625; rs885680; rs4726719; rs2371641; rs10241699; rs1618538; rs10952582; rs6977069; rs1860266; rs6464589; rs10237837; rs228577; rs10155925; rs6956531; rs4725653; rs11977858; rs6464590; rs7784291; rs4329196; rs2189909; rs7787855; rs10245384; rs7787183; rs11977126; rs7781953; rs6464605; rs10274162; rs6945905; rs6962350; rs6464597; rs13226218; rs992007; rs7796878; rs7801499; rs6946458; rs7777827; rs6979644; rs1406718; rs1635329; rs10251353; rs10258069; rs10487633; rs6464611; rs1320824; rs7357183; rs9648815; rs1731100; rs12703608; rs13437960; rs6957904; rs1320820; rs4726713; rs10487637; rs11975166; rs6464617; rs6464606; rs11983252; rs6957154; rs1623765; rs10500141; rs962778; rs10487634; rs7811469; rs4016354; rs10251902; rs6464616; rs17171057; rs6950704; rs7778089; rs7790675; rs7781909; rs1074318; rs6946454; rs17170969; rs194201; rs1731117; rs17169931; rs6464600; rs1635364; rs6976400; rs7802963; rs10224675; rs2056809; rs1074317; rs6968395; rs17169957; rs6464601; rs6972416; rs6464613; rs17170719; rs13228902; rs2189738; rs2189910; rs10487627; rs17170035; rs1635336; rs6945036; rs16883123; rs6464599; rs7808484; rs11977606; rs6967058; rs11976010; rs17170233; rs17170200; rs6951021; rs6961444; rs12703600; rs17170231; rs10952580; rs7798810; rs10255314; rs11975203; rs2699471; rs4446660; rs10243407; rs6961679; rs10234573; rs7810222; rs6978100; rs9648817; rs17170003; rs4371917; rs17170146; rs11970836; rs10230359; rs10266203; rs10952585; rs6943480; rs717884; rs6975998; rs6464615; rs4726706; rs10269062; rs17170034; rs11976655; rs6969058; rs12673185; rs13438549; rs13225630; rs17170295; rs4726711; rs17170078; rs17169930; rs11976835; rs11971703; rs11979362; rs10155967; rs3779088; rs10487631; rs7801694; rs17287011; rs4377875; rs994417; rs10487628; rs7781216; rs1320821; rs6946391; rs6464612; rs10487629; rs7801925; rs2189528; rs6976745; rs885679; rs2699469; rs11980517; rs10247940; rs11762292; rs7795072; rs7777512; rs17170270; rs10487635; rs11983061; rs7779949; rs17286117; rs11983686; rs7792518; rs12674073; rs12703605; rs11973993; rs228580; rs10232406; rs13228129; rs6946334; rs10223964; rs2158371; rs4725657; rs7791450; rs6956364; rs1406715; rs6954142; rs13232295; rs10487639; rs11977370; rs11768341; rs10253585; rs17171133; rs6957906; rs7779650; rs4726712; rs1320823; rs10280828; rs6464619; rs6974413; rs10224766; rs1731102; rs10268282; rs13240754; rs17171050; rs1635353; rs7781374; rs194200; rs228579; rs17170428; rs6942964; rs7801730; rs10231234; rs7791757; rs17170937; rs6966886; rs10271250; rs13223054; rs12703602; rs6972897; rs7780527; rs10487636; rs1547941; rs194202; rs6464618; rs2016609; rs1320825; rs10952583; rs10155825; rs6464593; rs964543; rs10281363; rs11762493; rs13245975; rs7803779; rs17170239; rs17169940; rs11978358; rs13438381; rs1635337; rs10229938; rs11978026; rs7790937; rs6975570; rs17170241; rs6956805; rs1635330; rs11766638; rs11974303; rs9640427; rs6955318; rs10247508; rs4726708; rs6464604; rs6464614; rs11979143; rs6968016; rs1007808; rs10234455; rs6958412; rs17169892; rs12671701; rs7783309; rs10241043; rs4392812; rs17209471; rs10230676; rs17169947; rs10272856; rs34724570; rs1635327; rs3779087; rs7809233; rs10264530; rs11765297; rs17209934; rs6969194; rs10215525; rs12533896; rs12703603; rs6464596; rs11973750; rs17170268; rs7785771; rs11976994; rs10250843; rs7799129; rs6973189; rs9648818; rs2699470; rs10215110; rs10260560; rs7784829; rs17170503; rs13237512; rs6952569; rs7810675; rs10231848; rs6975789; rs17170427; rs12666981; rs17170186; rs17170132; rs17170974; rs17170570; rs2005737; rs11773654; rs17170294; rs11769730; rs10247674; rs6974568; rs10240509; rs13228589; rs17170947; rs10225456; rs17170023; rs10215993; rs17170343; rs964544; rs1731111; rs6955032; rs7785284; rs11978854; rs1731099; rs7801322; rs17170507; rs6970944; rs1731118; rs12703607; rs10215445; rs10248143; rs7792383; rs10239036; rs6960039; rs12703620; rs11981756; rs6945262; rs10257344; rs10272207; rs13239232; rs11765254; rs7804254; rs10253185; rs2191034; rs10271239; rs10228971; rs10266578; rs12703597; rs10272031; rs10251905; rs6949326; rs7811618; rs7803304; rs12531082; rs17170766; rs990282; rs10227041; rs10261059; rs12667412; rs10280074; rs10225702; rs11975258; rs17170559; rs10257169; rs11978625; rs35105540; rs13438458; rs11979997; rs2888111; rs9691233; rs13438291; rs6951713; rs228583; rs17170990; rs6974499; rs7779856; rs6972950; rs10281473; rs7785126; rs10267573; rs41239; rs17170938; rs10215111; rs10280337; rs6973103; rs7800275; rs7806373; rs6976709; rs12667225; rs1611032; rs1635346; rs17291130; rs11974334; rs7799740; rs9632633; rs7809179; rs1731103; rs1731110; rs13437950; rs11982835; rs17170383; rs17170347; rs10242149; rs17170388; rs1635360; rs1731113; rs10227237; rs6959699; rs2371637; rs17170235; rs10234583; rs17170275; rs10952586; rs7785427; rs7797321; rs6959248; rs10241983; rs34833212; rs10241064; rs1635334; rs12703621; rs6971870; rs10253757; rs11973170; rs2888081; rs6954171; rs17288242; rs7807606; rs10229168; rs17170147; rs10155929; rs1731106; rs17170707; rs6963794; rs11977307; rs10269087; rs7805891; rs11761020; rs1731097; rs11772882; rs12540950; rs6962462; rs1731116; rs10252412; rs17170582; rs1635331; rs7805122; rs7798962; rs11974301; rs17170536; rs10225581; rs10267437; rs6975988; rs6977886; rs10231108; rs11983131; rs10273397; rs7792324; rs10235829; rs10278788; rs1635347; rs6953807; rs886470; rs185268; rs7789621; rs10270534; rs10265933; rs7792794; rs1635345; rs10271097; rs10257797; rs7782138; rs10256458; rs10232425; rs6942765; rs7805437; rs10246963; rs4726714; rs10487641; rs17170274; rs12535518; rs6946929; rs7798949; rs228585; rs7802449; rs6973229; rs11975020; rs6962117; rs6964316; rs7794078; rs10266099; rs17170148; rs11760287; rs6954906; rs2016558; rs2056810; rs6946570; rs6962884; rs7804957; rs12155485; rs11772321; rs17169932; rs17170311; rs10270978; rs10487632; rs10241869; rs17170259; rs17170980; rs7791623; rs2107374; rs38047; rs2371642; rs2699468; rs4726717; rs17169952; rs10215691; rs12538024; rs13437693; rs6943693; rs10155999; rs1635362; rs11971183; rs12667944; rs38048; rs11983207; rs16882757; rs10238191; rs7785036; rs7805299; rs12703599; rs10215790; rs10281315; rs7795655; rs7804252; rs7811587; rs10225287; rs10257071; rs11762567; rs6974646; rs10269305; rs10253203; rs10248365; rs17170302; rs6942512; rs6971371; rs17170557; rs6979603; rs12703606; rs10225412; rs12112819; rs7788575; rs13224460; rs1612175; rs1635348; rs6957602; rs10235794; rs11763621; rs12703626; rs1024482; rs35199404; rs35296397; rs34413035; rs35979683; rs35323247; rs36198471; rs34028342; rs6953564; rs28380423; rs6974579; rs6968218; rs28413104; rs10233334; rs34081525; rs35608653; rs17170323; rs10270434; rs35884064; rs6955338; rs7791310; rs2371639; rs28571028; rs6974902; rs35339555; rs1635351; rs34944933; rs16882877; rs12669269; rs28694858; rs28579156; rs10238513; rs10629073; rs11464025; rs12672821; rs7809533; rs35756383; rs28479418; rs13309788; rs11422807; rs4577879; rs34930119; rs35674701; rs7457749; rs35566802; rs10269206; rs7785422; rs38046; rs34531513; rs34738180; rs11971469; rs6969108; rs28500750; rs34144974; rs35184499; rs6967551; rs7776547; rs35482667; rs13232304; rs11317716; rs1548575; rs36198319; rs35519609; rs10273497; rs13247723; rs2888112; rs2888077; rs12540744; rs10241824; rs7776761; rs1635342; rs34094997; rs10694465; rs6943850; rs10249761; rs35035774; rs10260046; rs3042327; rs7800284; rs13230714; rs40449; rs35779190; rs28678413; rs1635343; rs35855148; rs7798791; rs34599911; rs1635332; rs28588904; rs5888135; rs6978711; rs28570563; rs9690136; rs28398209; rs36200340; rs28460839; rs34378654; rs3040230; rs34900846; rs10239447; rs34277149; rs28707604; rs10231535; rs1635339; rs35756798; rs6966100; rs35405843; rs35845182; rs28569289; rs10280947; rs2371635; rs11452942; rs13310276; rs10262120; rs10452883; rs34186186; rs34832014; rs10256622; rs28811933; rs10270637; rs11305202; rs36000797; rs36199082; rs6957482; rs36111540; rs12672805; rs34794877; rs6971947; rs35207726; rs34163873; rs35303317; rs5888143; rs12535732; rs34377801; rs34681993; rs35315060; rs34159734; rs2371554; rs10274473; rs35037991; rs6976076; rs35996306; rs35014628; rs28837141; rs35800302; rs4726709; rs34760157; rs35369530; rs34346934; rs34911080; rs10281612; rs34204932; rs10250234; rs10256565; rs34094760; rs36200486; rs6951872; rs28536068; rs194199; rs12534453; rs34330120; rs6975960; rs1055453; rs11435034; rs35644156; rs35978701; rs28775953; rs6957471; rs34314577; rs34182425; rs28427458; rs13230159; rs28510201; rs34038262; rs10240789; rs6976587; rs17170470; rs28692603; rs2371636; rs13311747; rs3040234; rs11362341; rs36209911; rs6970520; rs35470246; rs34021822; rs13234053; rs35415710; rs35938048; rs10593775; rs6967950; rs1548574; rs10238737; rs13310390; rs2189737; rs35554801; rs34141808; rs34192766; rs34238625; rs34948287; rs10232358; rs6956274; rs2057866; rs13230156; rs10085603; rs12538029; rs12538712; rs34988092; rs17170892; rs4262256; rs6943976; rs469; rs10265951; rs6977297; rs5888137; rs10658437; rs36116998; rs13308436; rs28639532; rs11489444; rs34894024; rs10655130; rs35217619; rs36199514; rs35300949; rs28835313; rs11428871; rs6964024; rs39735; rs10249039; rs4333506; rs10243867; rs6955193; rs10244709; rs35976110; rs34008497; rs6975937; rs35198172; rs11459424; rs34389743; rs35859259; rs34628831; rs34859474; rs11980885; rs34687078; rs5888134; rs35271069; rs10232281; rs10268498; rs6942661; rs34097180; rs28850986; rs11426233; rs17286328; rs13311753; rs35778131; rs35560423; rs13311623; rs5888144; rs35792643; rs35118178; rs35768955; rs10271182; rs11771584; rs34480903; rs35493620; rs36200202; rs34670673; rs6958138; rs34927725; rs12666545; rs12668441; rs34835858; rs34757054; rs28373706; rs34545047; rs34209356; rs11323491; rs12333969; rs36199564; rs28457759; rs7793564; rs35341680; rs28706735; rs10567168; rs35157162; rs28739475; rs34520276; rs41363945; rs33976824; rs28757305; rs35132271; rs28522992; rs10632503; rs35033973; rs1731112; rs13311804; rs7811412; rs35041655; rs2888110; rs13222470; rs2107704; rs2371553; rs28734052; rs35751974; rs6963103; rs35206140; rs10244564; rs34930287; rs35978858; rs7778979; rs2888078; rs28558557; rs35331491; rs10589255; rs10281906; rs34588679; rs35286552; rs17170954; rs34106076; rs28795378; rs4295579; rs34027991; rs3044348; rs10543167; rs13222495; rs11426234; rs28409990; rs1548573; rs35804126; rs2888080; rs10546043; rs2057867; rs721493; rs28416581; rs34364330; rs1635340; rs10259099; rs34751464; rs35781071; rs6961469; rs6976586; rs10259003; rs6955704; rs35534367; rs28446438; rs10228841; rs13226290; rs10617992; rs34973340; rs35046308; rs3042361; rs7801990; rs34293334; rs13244027; rs34996473; rs13310266; rs7783226; rs39734; rs10557050; rs35719032; rs34585243; rs33910286; rs34241727; rs35877047; rs41390745; rs11458445; rs35809882; rs13224012; rs9691696; rs35312120; rs2107594; rs34096470; rs35400271; rs12333550; rs36073499; rs34128452; rs34252477; rs35175758; rs34032314; rs13438550; rs13226835; rs13311636; rs6944562; rs13309846; rs10567204; rs35209194; rs35690993; rs34161706; rs34153786; rs13242178; rs11308799; rs6966035; rs10232022; rs28786814; rs6951096; rs13244177; rs3042322; rs35103734; rs10558709; rs35086397; rs35849498; rs7777606; rs11765957; rs34987667; rs28442063; rs7798112; rs28522580; rs10238330; rs2215219; rs17169737; rs35563476; rs10228708; rs34979900; rs28449706; rs1635361; rs34800357; rs13310271; rs12703598; rs34993548; rs7457429; rs41414146; rs190431; rs13222795; rs34597425; rs6964422; rs35013318; rs6952616; rs7779535; rs35541550; rs28552544; rs28542660; rs35165109; rs34897822; rs35476062; rs28699201; rs5888141; rs34185081; rs35382979; rs181894; rs35945248; rs40368; rs35818347; rs35523161; rs10604976; rs35570697; rs28725366; rs13229070; rs13225873; rs6971096; rs11411012; rs2286114; rs4131050; rs13247895; rs35339919; rs35852163; rs6969529; rs10557051; rs6950852; rs13246358; rs6953773; rs35296036; rs13232152; rs34729838; rs6977355; rs17170517; rs38045; rs28459424; rs13309945; rs34369030; rs28460679; rs35737363; rs35634524; rs9692511; rs34393220; rs2214659; rs28488966; rs34768056; rs35482339; rs10268690; rs35207416; rs35284407; rs11376814; rs34973552; rs6960537; rs2888079; rs35394584; rs10260761; rs34441284; rs34593661; rs2371552; rs28812608; rs7802782; rs34839054; rs12531270; rs13235615; rs10253653; rs2888076; rs1852920; rs35508316; rs11317717; rs34305365; rs35290006; rs34287334; rs36123752; rs34262669; rs13311683; rs765812; rs4725654; rs1635341; rs3898399; rs2107373; rs28408177; rs34484688; rs34901202; rs35730928; rs13244051; rs10238761; rs34704697; rs35554770; rs5888136; rs28823046; rs35218248; rs13311749; rs34679766; rs10540369; rs28379884; rs34607788; rs34830524; rs34689761; rs13222135; rs7789947; rs35349541; rs34752041; rs185267; rs2888113; rs13311798; rs35959153; rs7797325; rs10602923; rs17170998; rs13226427; rs35633085; rs28817333; rs34841600; rs35314913; rs13238731; rs35167828; rs28623518; rs13238741; rs9785003; rs34917325; rs2371640; rs13310293; rs13243114; rs28577219; rs28537713; rs35025705; rs13222577; rs17170992; rs6953169; rs2371638; rs35155664; rs2371555; rs1635333; rs5888139; rs1635338; rs11274078; rs34015229; rs34216477; rs28651346; rs35356645; rs35342492; rs6975790; rs4141300; rs35628627; rs6976124; rs35154558; rs34787271; rs12703601; rs35896011; rs12670718; rs12531380; rs228576; rs13311613; rs28627969; rs13228305; rs11324716; rs34396105; rs28526582; rs40369; rs10244181; rs10251258; rs13311628; rs10675570; rs28576380; rs13310451; rs6952749; rs10568701; rs13246072; rs10614981; rs34638493; rs34617104; rs34594490; rs34055045; rs13235696; rs28465013; rs6943869; rs35368759; rs35104700; rs5888140; rs35054445; rs35656270; rs35455933; rs10666264; rs35148952; rs34902799; rs35410191; rs6947050; rs11976889; rs13309656; rs34151594; rs3042378; rs3042375; rs7790338; rs5888142; rs35159296; rs10248366; rs3757473; rs35903043; rs12666684; rs10239406; rs10239416; rs11765140; rs11978900; rs17173040; rs4725652; rs4726701; rs4726702; rs4726705; rs6957884; rs7780224

# Metabolic_Enzyme_90_General_References:
11342117

# Metabolic_Enzyme_90_References:
Not Available

# Metabolic_Enzyme_91_ID:
5906

# Metabolic_Enzyme_91_Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor

# Metabolic_Enzyme_91_Synonyms:
GMP-PDE beta

# Metabolic_Enzyme_91_Gene_Name:
PDE6B

# Metabolic_Enzyme_91_Protein_Sequence:
>Rod cGMPspecific 3',5'cyclic phosphodiesterase subunit beta precursor
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVGRGCEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL

# Metabolic_Enzyme_91_Number_of_Residues:
854

# Metabolic_Enzyme_91_Molecular_Weight:
98408

# Metabolic_Enzyme_91_Theoretical_pI:
4.91

# Metabolic_Enzyme_91_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_91_General_Function:
Not Available

# Metabolic_Enzyme_91_Specific_Function:
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme

# Metabolic_Enzyme_91_Pathway:
Not Available

# Metabolic_Enzyme_91_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_91_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_91_Signals:
None

# Metabolic_Enzyme_91_Transmembrane_Regions:
None

# Metabolic_Enzyme_91_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_91_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_91_GenBank_ID_Protein:
252253

# Metabolic_Enzyme_91_SwissProt_ID:
PDE6B_HUMAN (P35913)

# Metabolic_Enzyme_91_swissprot_Name:
Not Available

# Metabolic_Enzyme_91_Genecard_id:
PDE6B

# Metabolic_Enzyme_91_Geneatlas_id:
PDE6B

# Metabolic_Enzyme_91_hgnc_id:
HGNC:8786

# Metabolic_Enzyme_91_PDB_ID:
Not Available

# Metabolic_Enzyme_91_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_91_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_91_Subcellular_Location:
Membrane; lipid-anchor

# Metabolic_Enzyme_91_Gene_Sequence:
>2565 bp
ATGAGCCTCAGTGAGGAGCAGGCCCGGAGCTTTCTGGACCAGAACCCCGATTTTGCCCGC
CAGTACTTTGGGAAGAAACTGAGCCCTGAGAATGTTGGCCGCGGCTGCGAGGACGGGTGC
CCGCCGGACTGCGACAGCCTCCGGGACCTCTGCCAGGTGGAGGAGAGCACGGCGCTGCTG
GAGCTGGTGCAGGATATGCAGGAGAGCATCAACATGGAGCGCGTGGTCTTCAAGGTCCTG
CGGCGCCTCTGCACCCTCCTGCAGGCCGACCGCTGCAGCCTCTTCATGTACCGCCAGCGC
AACGGCGTGGCCGAGCTGGCCACCAGGCTTTTCAGCGTGCAGCCGGACAGCGTCCTGGAG
GACTGCCTGGTGCCCCCCGACTCCGAGATCGTCTTCCCACTGGACATCGGGGTCGTGGGC
CACGTGGCTCAGACCAAAAAGATGGTGAACGTCGAGGACGTGGCCGAGTGCCCTCACTTC
AGCTCATTTGCTGACGAGCTCACTGACTACAAGACAAAGAATATGCTGGCCACACCCATC
ATGAATGGCAAAGACGTCGTGGCGGTGATCATGGCAGTGAACAAGCTCAACGGCCCATTC
TTCACCAGCGAAGACGAAGATGTGTTCTTGAAGTACCTGAATTTTGCCACGTTGTACCTG
AAGATCTATCACCTGAGCTACCTCCACAACTGCGAGACGCGCCGCGGCCAGGTGCTGCTG
TGGTCGGCCAACAAGGTGTTTGAGGAGCTGACGGACATCGAGAGGCAGTTCCACAAGGCC
TTCTACACGGTGCGGGCCTACCTCAACTGCGAGCGGTACTCCGTGGGCCTCCTGGACATG
ACCAAGGAGAAGGAATTTTTTGACGTGTGGTCTGTGCTGATGGGAGAGTCCCAGCCGTAC
TCGGGCCCACGCACGCCTGATGGCCGGGAAATTGTCTTCTACAAAGTGATCGACTACATC
CTCCACGGCAAGGAGGAGATCAAGGTCATTCCCACACCCTCAGCCGATCACTGGGCCCTG
GCCAGCGGCCTTCCAAGCTACGTGGCAGAAAGCGGCTTTATTTGTAACATCATGAATGCT
TCCGCTGACGAAATGTTCAAATTTCAGGAAGGGGCCCTGGACGACTCCGGGTGGCTCATC
AAGAATGTGCTGTCCATGCCCATCGTCAACAAGAAGGAGGAGATTGTGGGAGTCGCCACA
TTTTACAACAGGAAAGACGGGAAGCCCTTTGACGAACAGGACGAGGTTCTCATGGAGTCC
CTGACACAGTTCCTGGGCTGGTCAGTGATGAACACCGACACCTACGACAAGATGAACAAG
CTGGAGAACCGCAAGGACATCGCACAGGACATGGTCCTTTACCACGTGAAGTGCGACAGG
GACGAGATCCAGCTCATCCTGCCAACCAGAGCGCGCCTGGGGAAGGAGCCTGCTGACTGC
GATGAGGACGAGCTGGGCGAAATCCTGAAGGAGGAGCTGCCAGGGCCCACCACATTTGAC
ATCTACGAATTCCACTTCTCTGACCTGGAGTGCACCGAACTGGACCTGGTCAAATGTGGC
ATCCAGATGTACTACGAGCTGGGCGTGGTCCGAAAGTTCCAGATCCCCCAGGAGGTCCTG
GTGCGGTTCCTGTTCTCCATCAGCAAAGGGTACCGGAGAATCACCTACCACAACTGGCGC
CACGGCTTCAACGTGGCCCAGACGATGTTCACGCTGCTCATGACCGGCAAACTGAAGAGC
TACTACACGGACCTGGAGGCCTTCGCCATGGTGACAGCCGGCCTGTGCCATGACATCGAC
CACCGCGGCACCAACAACCTGTACCAGATGAAGTCCCAGAACCCCTTGGCTAAGCTCCAC
GGCTCCTCGATTTTGGAGCGGCACCACCTGGAGTTTGGGAAGTTCCTGCTCTCGGAGGAG
ACCCTGAACATCTACCAGAACCTGAACCGGCGGCAGCACGAGCACGTGATCCACCTGATG
GACATCGCCATCATCGCCACGGACCTGGCCCTGTACTTCAAGAAGAGAGCGATGTTTCAG
AAGATCGTGGATGAGTCCAAGAACTACCAGGACAAGAAGAGCTGGGTGGAGTACCTGTCC
CTGGAGACGACCCGGAAGGAGATCGTCATGGCCATGATGATGACAGCCTGCGACCTGTCT
GCCATCACCAAGCCCTGGGAAGTCCAGAGCAAGGTCGCACTTCTCGTGGCTGCTGAGTTC
TGGGAGCAAGGTGACTTGGAAAGGACAGTCTTGGATCAGCAGCCCATTCCTATGATGGAC
CGGAACAAGGCGGCCGAGCTCCCCAAGCTGCAAGTGGGCTTCATCGACTTCGTGTGCACA
TTCGTGTACAAGGAGTTCTCTCGTTTCCACGAAGAGATCCTGCCCATGTTCGACCGACTG
CAGAACAATAGGAAAGAGTGGAAGGCGCTGGCTGATGAGTATGAGGCCAAAGTGAAGGCT
CTGGAGGAGAAGGAGGAGGAGGAGAGGGTGGCAGCCAAGAAAGTAGGCACAGAAATTTGC
AATGGCGGCCCAGCACCCAAGTCTTCAACCTGCTGTATCCTGTGA

# Metabolic_Enzyme_91_GenBank_ID_Gene:
S41458

# Metabolic_Enzyme_91_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_91_Locus:
4p16.3

# Metabolic_Enzyme_91_SNPs:
rs10029928; rs10007497; rs13101691; rs10030020; rs10023472; rs10029924; rs4075653; rs9994679; rs13133935; rs7438471; rs10031968; rs9997286; rs13116523; rs9998466; rs10033239; rs10017347; rs7669178; rs9999833; rs35925646; rs11734693; rs9991058; rs13127213; rs1135375; rs10031745; rs12501038; rs4426719; rs9995112; rs3895658; rs9996400; rs3888807; rs4690185; rs28568555; rs9992641; rs13139089; rs10027866; rs3891250; rs12331186; rs9998594; rs13117283; rs9998967; rs9996316; rs9998776; rs10027392; rs13107358; rs28414606; rs17849286; rs10902758; rs35792756; rs28510278; rs34380508; rs34749277; rs13106957; rs28675771; rs28710261; rs35513604; rs28862677; rs28538930; rs35535457; rs6858313; rs4292282; rs34281091; rs35498946; rs35714333; rs10010598; rs34698095; rs35621580; rs35691873; rs28711586; rs5021192; rs3934456; rs5855674; rs11945763; rs10050278; rs28588872; rs28569875; rs5021190; rs28583078; rs28483058; rs3929990; rs9985747; rs35214302; rs35436502; rs28438722; rs34845372; rs34165278; rs28573204; rs28459140; rs10028526; rs34477049; rs28600205; rs34953355; rs10018607; rs34587890; rs10014936; rs34149873; rs13133489; rs28520978; rs3929992; rs10028537; rs34992186; rs4690283; rs5021193; rs4505760; rs35207129; rs36117387; rs34568772; rs10027549; rs34524643; rs13143262; rs28374488; rs35935310; rs3929994; rs13143260; rs13103955; rs28476575; rs36060793; rs10024023; rs34096984; rs28742899; rs3934458; rs28754797; rs4690184; rs13143415; rs28502612; rs34328631; rs13140649; rs35564967; rs35134635; rs34549884; rs34177362; rs13119631; rs35732782; rs10011154; rs28615478; rs34101587; rs28438498; rs34391278; rs28478159; rs10001451; rs3934457; rs28469188; rs35448666; rs13114329; rs28380593; rs11932953; rs4690287; rs34415705; rs3934459; rs9990446; rs28742266; rs28399001; rs28485445; rs4549330; rs35694609; rs28407346; rs10017435; rs28818828; rs10023609; rs35649145; rs34902595; rs5021189; rs34612826; rs34585712; rs28605120; rs5021195; rs3864131; rs28706206; rs35669257; rs3864130; rs35400657; rs28514424; rs13114327; rs3929991; rs34363025; rs28413992; rs35584659; rs34366493; rs34907702; rs10002807; rs7436737; rs35137658; rs35978649; rs34721231; rs36093261; rs34421911; rs13109818; rs35972513; rs28483373; rs28630797; rs33997822; rs13104193; rs3929993; rs34756574; rs35958508; rs34358706; rs35847945; rs35894204; rs28687729; rs10035021; rs28436699; rs5021194; rs13119162; rs35853545; rs5021191; rs34801629; rs35556851; rs28586910; rs28504161; rs13140494; rs28488910; rs10007206; rs35869797; rs34290798; rs7699579; rs4446259; rs13115440; rs28477853; rs28535694; rs5021196; rs34094325; rs28665728; rs35199616; rs9998968; rs13107385; rs13128568; rs13147797; rs13128747; rs13104878; rs13145071; rs1802515; rs28525003; rs34268219; rs34307246; rs35091443; rs4463020; rs4690183; rs7665160

# Metabolic_Enzyme_91_General_References:
8394243; 1338685; 1322354; 1720239; 8768262; 8394174; 8075643; 7951329; 8595886; 8698075; 8557257; 8956055; 9543643

# Metabolic_Enzyme_91_References:
Not Available

# Metabolic_Enzyme_92_ID:
5908

# Metabolic_Enzyme_92_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D

# Metabolic_Enzyme_92_Synonyms:
DPDE3; PDE43

# Metabolic_Enzyme_92_Gene_Name:
PDE4D

# Metabolic_Enzyme_92_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
DMEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPP
PPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCR
AMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQ
ANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNN
FAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKR
PMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRP
LTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLS
TPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGV
LLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPM
CDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPA
PDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIP
LDEQVEEEAVGEEEESQPEACVIDDRSPDT

# Metabolic_Enzyme_92_Number_of_Residues:
809

# Metabolic_Enzyme_92_Molecular_Weight:
91116

# Metabolic_Enzyme_92_Theoretical_pI:
5.25

# Metabolic_Enzyme_92_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_92_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_92_Specific_Function:
Regulates the levels of cAMP in the cell

# Metabolic_Enzyme_92_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_92_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_92_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_92_Signals:
None

# Metabolic_Enzyme_92_Transmembrane_Regions:
None

# Metabolic_Enzyme_92_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_92_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_92_GenBank_ID_Protein:
347130

# Metabolic_Enzyme_92_SwissProt_ID:
PDE4D_HUMAN (Q08499)

# Metabolic_Enzyme_92_swissprot_Name:
Not Available

# Metabolic_Enzyme_92_Genecard_id:
PDE4D

# Metabolic_Enzyme_92_Geneatlas_id:
PDE4D

# Metabolic_Enzyme_92_hgnc_id:
HGNC:8783

# Metabolic_Enzyme_92_PDB_ID:
Not Available

# Metabolic_Enzyme_92_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_92_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_92_Subcellular_Location:
Cytoplasm. Membrane (By similarity). Cytoplasm; cytoskeleton (By similarity). Centrosome (By similarity). Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity)

# Metabolic_Enzyme_92_Gene_Sequence:
>2024 bp
ACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGTGG
ACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGC
TAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCG
ACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATA
TACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTG
TACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCAC
CCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAAC
TGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGA
CCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGTTTAAAAGGATGCTTAATCGGGAGC
TCACCCATCTCTCTGAAATGAGTCGGTCTGGAAATCAAGTGTCAGAGTTTATATCAAACA
CATTCTTAGATAAGCAACATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGA
AAAAGAAAAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAGTC
TGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGATGTCCTTGCCA
AGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTTCAGAATAGCAGAGTTGTCTG
GTAACCGGCCCTTGACTGTTATCATGCACACCATTTTTCAGGAACGGGATTTATTAAAAA
CATTTAAAATTCCAGTAGATACTTTAATTACATATCTTATGACTCTCGAAGACCATTACC
ATGCTGATGTGGCCTATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATG
TGCTATTATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCAA
TTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAATTTCTGATCA
ATACAAACTCTGAACTTGCCTTGATGTACAATGATTCCTCAGTCTTAGAGAACCATCATT
TGGCTGTGGGCTTTAAATTGCTTCAGGAAGAAAACTGTGACATTTTCCAGAATTTGACCA
AAAAACAAAGACAATCTTTAAGGAAAATGGTCATTGACATCGTACTTGCAACAGATATGT
CAAAACACATGAATCTACTGGCTGATTTGAAGACTATGGTTGAAACTAAGAAAGTGACAA
GCTCTGGAGTTCTTCTTCTTGATAATTATTCCGATAGGATTCAGGTTCTTCAGAATATGG
TGCACTGTGCAGATCTGAGCAACCCAACAAAGCCTCTCCAGCTGTACCGCCAGTGGACGG
ACCGGATAATGGAGGAGTTCTTCCGCCAAGGAGACCGAGAGAGGGAACGTGGCATGGAGA
TAAGCCCCATGTGTGACAAGCACAATGCTTCCGTGGAAAAATCACAGGTGGGCTTCATAG
ACTATATTGTTCATCCCCTCTGGGAGACATGGGCAGACCTCGTCCACCCTGACGCCCAGG
ATATTTTGGACACTTTGGAGGACAATCGTGAATGGTACCAGAGCACAATCCCTCAGAGCC
CCTCTCCTGCACCTGATGACCCAGAGGAGGGCCGGCAGGGTCAAACTGAGAAATTCCAGT
TTGAACTAACTTTAGAGGAAGATGGTGAGTCAGACACGGAAAAGGACAGTGGCAGTCAAG
TGGAAGAAGACACTAGCTGCAGTGACTCCAAGACTCTTTGTACTCAAGACTCAGAGTCTA
CTGAAATTCCCCTTGATGAACAGGTTGAAGAGGAGGCAGTAGGGGAAGAAGAGGAAAGCC
AGCCTGAAGCCTGTGTCATAGATGATCGTTCTCCTGACACGTAA

# Metabolic_Enzyme_92_GenBank_ID_Gene:
L20970

# Metabolic_Enzyme_92_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_92_Locus:
5q12

# Metabolic_Enzyme_92_SNPs:
rs7736186; rs702530; rs702531; rs10075508; rs10036063; rs10940636; rs829259; rs10035437; rs829260; rs17719258; rs3839219; rs12658211; rs1471430; rs35285; rs1961; rs702543; rs1374028; rs1824159; rs1014317; rs1391651; rs244574; rs383444; rs2607347; rs244593; rs992726; rs27727; rs159195; rs2910642; rs40125; rs2409625; rs1498599; rs35286; rs1867724; rs702544; rs1348710; rs1395336; rs27957; rs171800; rs258125; rs35260; rs455969; rs1348709; rs35309; rs258110; rs27183; rs40126; rs27548; rs1498611; rs27549; rs441817; rs2702372; rs37569; rs1445918; rs716908; rs372309; rs149084; rs27949; rs27170; rs35255; rs1031197; rs40122; rs35310; rs1445948; rs294485; rs35265; rs26701; rs244577; rs28054; rs2968012; rs2968019; rs149106; rs167161; rs1345793; rs153968; rs986067; rs35281; rs40215; rs37353; rs294478; rs154222; rs35262; rs2936190; rs2014012; rs35282; rs1391649; rs2968009; rs35279; rs1078368; rs26712; rs1559251; rs2910641; rs1471429; rs1038080; rs889231; rs294482; rs35289; rs28044; rs922434; rs424839; rs187716; rs2591825; rs2547917; rs2968015; rs1391650; rs37575; rs377451; rs35277; rs988828; rs525099; rs2968011; rs929820; rs670169; rs1838733; rs921942; rs181736; rs1345792; rs2968003; rs154224; rs26708; rs27184; rs35274; rs35280; rs26711; rs988827; rs765182; rs159196; rs26705; rs154223; rs1579846; rs2409629; rs11958956; rs1023814; rs185333; rs26694; rs1423308; rs370891; rs9968728; rs258105; rs3805554; rs6892369; rs9292197; rs7724713; rs244590; rs2168649; rs4700316; rs1445952; rs2968014; rs35278; rs7707541; rs6861969; rs10043357; rs6450505; rs294494; rs2702373; rs2968006; rs258109; rs27172; rs1541672; rs255648; rs2409630; rs6886495; rs1498600; rs11744761; rs433565; rs6886854; rs244587; rs187645; rs6450496; rs27898; rs244566; rs7727206; rs1823068; rs10059053; rs26700; rs3763083; rs427433; rs6874460; rs10062176; rs1553114; rs1824788; rs2409627; rs27547; rs2194210; rs26695; rs889229; rs10056754; rs1870077; rs11951359; rs7703022; rs153980; rs1990985; rs7703658; rs10061553; rs27395; rs10062397; rs4618401; rs37576; rs255650; rs294496; rs35287; rs10067048; rs6450521; rs153966; rs7700365; rs159197; rs7717802; rs35267; rs1874859; rs258128; rs7724786; rs997421; rs27171; rs2910643; rs10038704; rs26709; rs171801; rs1824154; rs401013; rs165940; rs736736; rs10052657; rs464311; rs6886791; rs6450502; rs4700328; rs256752; rs7728050; rs37572; rs244575; rs6861992; rs6893655; rs154031; rs9292200; rs1551938; rs2013979; rs294500; rs1156029; rs4551023; rs2968005; rs1156028; rs35258; rs1445947; rs26710; rs6875727; rs7723432; rs11952840; rs12654005; rs294483; rs6879949; rs172362; rs721826; rs6877743; rs10461656; rs26687; rs153978; rs7713369; rs244570; rs1947090; rs1817248; rs7712329; rs291122; rs6874089; rs6869400; rs1077183; rs7719441; rs4700317; rs1506557; rs7730070; rs10805513; rs10940644; rs6895685; rs2607343; rs10071163; rs1867711; rs27168; rs151802; rs154024; rs153982; rs12697177; rs35275; rs6450515; rs9292202; rs6450518; rs154028; rs6450512; rs255633; rs12697173; rs10041021; rs258107; rs37574; rs1350298; rs11746896; rs153985; rs1353748; rs9292195; rs1848060; rs10037973; rs258121; rs10062340; rs371775; rs10075104; rs291118; rs2968004; rs4700325; rs12697171; rs7443333; rs154025; rs2028842; rs13176291; rs378858; rs244573; rs2409631; rs6450498; rs153961; rs6883834; rs10064744; rs6887017; rs1457145; rs255649; rs7728286; rs2098699; rs1551564; rs10035950; rs2028836; rs40328; rs1553113; rs6897568; rs7735228; rs6877508; rs1862563; rs1445954; rs7735376; rs153979; rs149108; rs26688; rs1551939; rs4699932; rs244592; rs40444; rs1498601; rs1395337; rs27773; rs7734053; rs6450514; rs3852147; rs6450519; rs6867240; rs6450516; rs13356883; rs258111; rs4700315; rs6881054; rs1876209; rs244594; rs1457110; rs11957770; rs26714; rs7734070; rs244595; rs26715; rs6885378; rs6867053; rs12652499; rs378970; rs294484; rs244596; rs11958928; rs3805553; rs9292198; rs6877927; rs10066573; rs9283720; rs368538; rs181915; rs1345791; rs10223103; rs294492; rs392901; rs26689; rs1971061; rs1391648; rs244591; rs255647; rs12055306; rs1353749; rs7712076; rs6898374; rs7735572; rs1546221; rs1971940; rs10037958; rs37571; rs1445953; rs1035321; rs2702363; rs2112957; rs10940638; rs153981; rs6893668; rs10055769; rs464787; rs6870632; rs26702; rs10055954; rs2968018; rs35307; rs13328162; rs4699935; rs16889904; rs6450510; rs258112; rs35263; rs10040847; rs255557; rs256750; rs6450517; rs294497; rs17720639; rs16888990; rs10514861; rs16889611; rs13185828; rs1498608; rs11743194; rs27179; rs6450506; rs12518641; rs12655617; rs244571; rs3891334; rs10461657; rs11959801; rs16889427; rs974766; rs39672; rs7735570; rs7724814; rs10514864; rs1120303; rs4699941; rs10068543; rs11954668; rs16889885; rs6892860; rs153949; rs2607340; rs2936193; rs7729339; rs2591750; rs6896121; rs2591744; rs17797781; rs381755; rs13362239; rs10045879; rs10472081; rs10058478; rs1363882; rs9292205; rs7733296; rs10051287; rs10472105; rs11747104; rs13358738; rs10070436; rs2055297; rs17589766; rs9292186; rs295936; rs7701455; rs11740402; rs35259; rs6450522; rs428059; rs2547918; rs6869149; rs10065303; rs17528473; rs13155290; rs9292182; rs1874857; rs6891130; rs12186707; rs1838721; rs27175; rs10072367; rs6889851; rs7707392; rs6859139; rs27185; rs27695; rs2591749; rs13185063; rs17795692; rs28055; rs16889920; rs244581; rs17444185; rs244579; rs7712725; rs16889849; rs1909294; rs12514190; rs2081106; rs11738043; rs11952875; rs2081093; rs35305; rs2036220; rs13176475; rs7716276; rs16889805; rs154027; rs27181; rs35283; rs17589633; rs1813481; rs27187; rs10064893; rs433161; rs12109774; rs16889518; rs1541673; rs10471467; rs7717819; rs1960; rs4700314; rs7714707; rs10039312; rs187644; rs2034894; rs1823070; rs258106; rs255579; rs13160617; rs6450501; rs35284; rs13176940; rs2059191; rs11739293; rs13180599; rs6864156; rs255655; rs10472093; rs244582; rs1848059; rs27182; rs10069146; rs10065334; rs12697170; rs13354437; rs1975533; rs6888644; rs174039; rs11952011; rs17796734; rs35261; rs9292189; rs6867591; rs10041537; rs2216699; rs16889682; rs17528543; rs931855; rs37573; rs16888998; rs6450513; rs2547920; rs3816996; rs27174; rs6888474; rs10068836; rs12187079; rs10472106; rs16889508; rs1439; rs2055298; rs2702365; rs7714708; rs17528285; rs669240; rs17726292; rs258127; rs6450497; rs7703702; rs10085076; rs17721878; rs414746; rs16889796; rs17727615; rs4700321; rs2591748; rs10514871; rs11747413; rs2112910; rs11957827; rs10055095; rs4699939; rs6861842; rs10045878; rs11744488; rs209983; rs11951879; rs16889853; rs1115728; rs4321723; rs7717303; rs7719347; rs13355884; rs10075067; rs378869; rs16889280; rs16889907; rs244583; rs7723695; rs37579; rs9292185; rs12654485; rs27641; rs9292199; rs2591651; rs255652; rs10514863; rs10074854; rs17780175; rs2591826; rs13355401; rs10058672; rs2021384; rs1579848; rs2112956; rs294479; rs12517657; rs17444059; rs10471463; rs7733716; rs7730574; rs10471466; rs291119; rs487029; rs12656462; rs16889906; rs294491; rs10070294; rs10514860; rs6876934; rs651576; rs10038599; rs7737685; rs6871710; rs6862702; rs12657171; rs294481; rs12187448; rs12658554; rs2034893; rs13161623; rs7703452; rs573336; rs10472102; rs467300; rs16889874; rs11948651; rs6897015; rs16889512; rs7711639; rs11748392; rs6858946; rs16889175; rs6890598; rs697076; rs17778950; rs10058681; rs10461659; rs7707065; rs1542842; rs7701945; rs6896497; rs1605275; rs172363; rs11959132; rs10063540; rs6865647; rs1823066; rs13180690; rs10051847; rs42470; rs1105577; rs6891161; rs4700322; rs434422; rs10491352; rs9292188; rs27188; rs13361218; rs11957151; rs16889495; rs387647; rs6895550; rs193447; rs1498606; rs12518773; rs244568; rs294498; rs10491353; rs12658429; rs7730750; rs10514866; rs17782374; rs17776879; rs2441091; rs10073507; rs10055884; rs10065699; rs826435; rs16889883; rs10056637; rs10051191; rs6450509; rs12522563; rs153948; rs294476; rs12519611; rs16889129; rs17777413; rs16889248; rs6875867; rs17782969; rs27176; rs10071881; rs17796040; rs1395335; rs10514865; rs427748; rs7717821; rs16889810; rs11750426; rs7706227; rs427740; rs10514870; rs12514658; rs10058823; rs444552; rs10059709; rs17776825; rs1078369; rs1874858; rs244588; rs1445950; rs10044687; rs16889869; rs17780213; rs17780860; rs16889126; rs9292194; rs10056492; rs2968010; rs294474; rs950446; rs16889615; rs10043404; rs10038299; rs6450504; rs545611; rs2055296; rs10472082; rs6875027; rs4631140; rs17783275; rs26703; rs10440630; rs27178; rs10074426; rs10514862; rs10940642; rs9292206; rs1867725; rs13357758; rs9292184; rs17782238; rs35306; rs11948070; rs6892879; rs3805557; rs10036406; rs6858964; rs2968013; rs12653844; rs244580; rs6898269; rs6889456; rs10068809; rs6872134; rs6862564; rs11949561; rs10038855; rs17528634; rs17727092; rs7700870; rs2081092; rs13153653; rs6898082; rs2702369; rs12186633; rs3805556; rs16889412; rs3763084; rs425384; rs27670; rs13362115; rs2702371; rs35276; rs11960438; rs154221; rs255635; rs186078; rs7736808; rs10805515; rs27180; rs10058676; rs40216; rs918583; rs10079396; rs13160457; rs10036199; rs1457146; rs3901540; rs16889921; rs16889276; rs10077993; rs17443709; rs255654; rs7717248; rs11948356; rs1559252; rs6888028; rs10471465; rs17797996; rs16889876; rs6866342; rs6872808; rs17740767; rs454702; rs13162275; rs7735375; rs953302; rs10069009; rs389324; rs9918228; rs1457111; rs11738454; rs10077018; rs26704; rs244565; rs13173038; rs7715956; rs11949324; rs6871806; rs17723785; rs4479801; rs2059175; rs4699930; rs13355507; rs6896337; rs7707043; rs13189127; rs3903515; rs6894694; rs9918111; rs16889882; rs2547921; rs12656663; rs7728221; rs11956680; rs171729; rs10052856; rs6859693; rs6871410; rs10155628; rs17795596; rs10070295; rs1840838; rs16889912; rs153965; rs6884572; rs294503; rs10042425; rs16877155; rs13354210; rs17796824; rs6869578; rs6893986; rs11952435; rs13186012; rs17528453; rs6875497; rs17721311; rs697075; rs10073292; rs16889254; rs443191; rs11950805; rs1579845; rs10461660; rs11952527; rs1115729; rs13167220; rs16889908; rs294486; rs258123; rs6896519; rs7733300; rs9292193; rs244576; rs17741863; rs364528; rs7714403; rs10035390; rs11951025; rs17780740; rs13328175; rs682796; rs13362242; rs16889892; rs10940645; rs6876057; rs17719378; rs10472089; rs11955850; rs294499; rs9647533; rs10042606; rs931856; rs2968002; rs9918215; rs13189942; rs16889307; rs10514859; rs17528578; rs17777280; rs17721133; rs17722929; rs1644948; rs10043994; rs10061786; rs27532; rs2702375; rs12656132; rs2936201; rs13188077; rs13176997; rs10072637; rs6877740; rs7708183; rs1579849; rs2409628; rs2968001; rs16889901; rs1353747; rs34738; rs11749543; rs11954898; rs10077198; rs9687424; rs9292196; rs17528550; rs9292190; rs7729722; rs17725522; rs3805555; rs6877256; rs10056526; rs12521370; rs10472084; rs10055446; rs13177192; rs17720871; rs17721860; rs2409646; rs7726987; rs256120; rs6894618; rs7732124; rs11742439; rs958851; rs255651; rs6871017; rs10044336; rs12658004; rs922437; rs6892534; rs9292201; rs10039006; rs10058483; rs7707566; rs13357723; rs10042726; rs10472101; rs2409614; rs16889948; rs10062858; rs13187670; rs11747358; rs2061282; rs13360359; rs7716261; rs11956820; rs244586; rs17780584; rs16877169; rs17779217; rs1846369; rs10059809; rs291117; rs10042103; rs490105; rs6879216; rs13178514; rs258108; rs13360195; rs33927508; rs6870929; rs13154145; rs13361668; rs35308; rs7444432; rs950447; rs159194; rs13328174; rs16889167; rs2112959; rs13361223; rs1077978; rs6882204; rs13188962; rs4629551; rs2702361; rs10940640; rs10069187; rs17628114; rs11739354; rs10039990; rs6875884; rs17777617; rs2936199; rs7729776; rs17740749; rs10061320; rs1498609; rs1463816; rs10214048; rs13154828; rs2021776; rs1823067; rs380993; rs9918225; rs9292192; rs12522220; rs16889606; rs13165581; rs2968021; rs16889521; rs35288; rs244569; rs190433; rs1973450; rs4700335; rs16889919; rs10472107; rs12187317; rs16889274; rs153983; rs294477; rs403695; rs4699931; rs10155599; rs16889903; rs10051456; rs11955452; rs10070138; rs258120; rs1947095; rs6872107; rs16889913; rs10062986; rs34739; rs5010782; rs244585; rs387997; rs1108916; rs1909295; rs26713; rs10035257; rs6868963; rs10037978; rs419953; rs2161513; rs10035719; rs2936202; rs17528257; rs10040394; rs391377; rs2607349; rs149506; rs573230; rs7710479; rs244597; rs10055869; rs7704805; rs2702377; rs294495; rs13355229; rs16889484; rs11950544; rs35266; rs16889865; rs466978; rs11738525; rs1974839; rs17528522; rs6450520; rs403687; rs10063703; rs6890168; rs4700318; rs1532520; rs7701758; rs10068715; rs12521279; rs36064814; rs7713345; rs7719732; rs6874473; rs4326095; rs13183985; rs16889392; rs13328160; rs10155544; rs10940641; rs10052063; rs10065078; rs6870927; rs4395595; rs1463817; rs10045258; rs168641; rs17796399; rs6883494; rs153967; rs17776777; rs12186492; rs434274; rs10042733; rs10452450; rs16889499; rs1902609; rs10065206; rs371398; rs2591751; rs11959567; rs10471470; rs7729912; rs10044298; rs28385324; rs3087748; rs16889925; rs17740844; rs11955845; rs17797601; rs12188859; rs13169097; rs12697174; rs2591747; rs10054429; rs10079544; rs34235034; rs380118; rs6895303; rs6891589; rs13190249; rs8180396; rs10064468; rs10079614; rs11957508; rs1379297; rs4699937; rs6883346; rs10051023; rs6897538; rs12108729; rs13358203; rs16877156; rs12188029; rs16889878; rs258122; rs13328226; rs7716975; rs931857; rs11747768; rs16889896; rs10059338; rs2021775; rs13164981; rs17724250; rs2059174; rs258104; rs11746579; rs27173; rs7711904; rs244584; rs16889696; rs6875906; rs403672; rs16889190; rs10043671; rs10036287; rs294501; rs17798241; rs10065540; rs17798319; rs10040395; rs17741233; rs9292181; rs17589745; rs9686835; rs255812; rs6876050; rs13173495; rs10039572; rs10067196; rs10472098; rs10038321; rs16889743; rs16889161; rs17721564; rs10042327; rs16889846; rs2702360; rs10155627; rs13354657; rs16889478; rs6881137; rs10075364; rs10214073; rs13161585; rs10061206; rs4395596; rs382411; rs2216687; rs16889733; rs17781354; rs6863716; rs10057278; rs374713; rs1160958; rs16889227; rs9918223; rs419744; rs4700329; rs291120; rs258129; rs40203; rs10065498; rs9687262; rs9716722; rs17728654; rs7736385; rs1598740; rs8180419; rs10035212; rs6897504; rs1902610; rs6874662; rs6892252; rs10075171; rs13174180; rs11746624; rs27189; rs9292187; rs154023; rs13362296; rs10077672; rs12656944; rs13178315; rs10060200; rs16889258; rs3815764; rs10078763; rs6891288; rs153969; rs2277014; rs11739601; rs17725949; rs35264; rs16889181; rs16889479; rs4469166; rs4618402; rs154026; rs168834; rs10053330; rs2291851; rs2936200; rs17720311; rs7735133; rs6450508; rs1498612; rs10078754; rs11744259; rs7706044; rs466376; rs2409626; rs7702291; rs27723; rs17780836; rs4699938; rs12655844; rs11950492; rs13160982; rs10071088; rs11959349; rs10472110; rs11956001; rs829258; rs17291089; rs11950495; rs1058458; rs17853590; rs17853589; rs1058459; rs35684984; rs35839600; rs12187668; rs34530754; rs35859095; rs34835493; rs3839217; rs3839218; rs10718401; rs35914743; rs34128632; rs34115255; rs922435; rs34848147; rs35818307; rs27186; rs10574102; rs1209433; rs13169163; rs11365445; rs28505532; rs2034895; rs28725359; rs6149040; rs35851251; rs649476; rs34677469; rs35617728; rs13162482; rs35860266; rs11365791; rs35776313; rs258117; rs11413392; rs1143233; rs33950471; rs34854664; rs34187013; rs35879110; rs211670; rs35244458; rs2409613; rs7727032; rs33976406; rs1871181; rs34207840; rs294480; rs35785066; rs10660174; rs35366471; rs10079826; rs10586960; rs28461689; rs16889366; rs34060514; rs33991327; rs11418242; rs34996240; rs11436951; rs35078554; rs2936197; rs34455241; rs11401918; rs7700296; rs10056649; rs34563226; rs1813483; rs10603279; rs36048558; rs2591743; rs35264771; rs11429076; rs2702362; rs34153401; rs34555936; rs447261; rs1867712; rs10045441; rs10656770; rs159393; rs34567562; rs374691; rs12517094; rs11305111; rs5868184; rs10682149; rs35798154; rs3061653; rs13165285; rs36227655; rs6882478; rs7716631; rs6880249; rs12659081; rs34058811; rs34126067; rs12521516; rs34154445; rs6886569; rs7734463; rs1202161; rs13171241; rs35731466; rs34984294; rs2409648; rs2936189; rs34935059; rs4558950; rs13170796; rs11383327; rs7737978; rs34726071; rs1075641; rs35098298; rs7723289; rs13184217; rs35011298; rs6864694; rs4513648; rs10536982; rs11444928; rs34296140; rs36019972; rs35561012; rs35182475; rs2936203; rs5868170; rs10693866; rs5868155; rs34492945; rs1974836; rs36226812; rs3061616; rs13176721; rs34863757; rs1498610; rs10056619; rs11448342; rs1143230; rs33969423; rs34222623; rs35643183; rs34682234; rs35037415; rs36121613; rs34924381; rs190486; rs5868182; rs35842486; rs35507986; rs13156498; rs35924466; rs35092276; rs2936191; rs3989138; rs10472097; rs11447857; rs13177495; rs34301317; rs34696511; rs10581563; rs295934; rs10563874; rs5868157; rs2001663; rs34033893; rs34118182; rs34733788; rs34838287; rs34660223; rs28568571; rs28688372; rs35238877; rs7701039; rs3061422; rs13165299; rs34596458; rs35985169; rs3060393; rs34138345; rs34991840; rs34493562; rs13358946; rs4604141; rs35802681; rs28427182; rs35854938; rs34714025; rs1840846; rs10626836; rs17444108; rs3061651; rs2409645; rs34310135; rs13359304; rs10587602; rs244567; rs34120574; rs7700594; rs458953; rs7731885; rs13179931; rs2702364; rs3061709; rs35613781; rs34091391; rs33952315; rs34508989; rs35205837; rs1038079; rs35260023; rs34651837; rs11746156; rs5868167; rs34523714; rs34074485; rs977465; rs35035421; rs33915770; rs34756714; rs13357070; rs34505227; rs7731299; rs34047116; rs7445308; rs28403116; rs35338151; rs34172825; rs34418802; rs35926698; rs10672523; rs13154098; rs35376564; rs166261; rs34339765; rs2591752; rs13178411; rs1973451; rs28696115; rs17528223; rs34612377; rs35425879; rs6898554; rs34234985; rs10053177; rs35406293; rs2291852; rs7723589; rs35238842; rs34018147; rs1974840; rs34088870; rs28595613; rs255459; rs13159623; rs722010; rs35119819; rs1143231; rs185320; rs4426880; rs13359998; rs13171236; rs4619980; rs28713675; rs35883616; rs5868186; rs381332; rs28372523; rs36228173; rs13189436; rs34571539; rs34740; rs35047246; rs11461880; rs35450213; rs35253855; rs34686327; rs35126822; rs34685247; rs17443688; rs34086576; rs10472091; rs13190508; rs2547919; rs7738023; rs13157164; rs34990310; rs34269653; rs11371708; rs5868177; rs36172625; rs3061656; rs34308828; rs35455534; rs2607345; rs13159548; rs187368; rs13157341; rs4700323; rs1824157; rs1075640; rs35021239; rs1031198; rs3061658; rs35903843; rs13156940; rs11338647; rs13187400; rs2054443; rs3061710; rs34235697; rs3061308; rs35151567; rs440664; rs34472588; rs36088481; rs1813482; rs7711649; rs34084892; rs13360916; rs10572313; rs11349021; rs34207293; rs5868174; rs28424104; rs7715430; rs33940460; rs294502; rs13354612; rs7713258; rs5868152; rs36027270; rs3060391; rs10562385; rs28647633; rs35687752; rs7735196; rs35969214; rs10078108; rs36003579; rs33946616; rs7712922; rs2898243; rs432879; rs13362039; rs28620612; rs35979851; rs27691; rs35491995; rs10058612; rs13178256; rs10617961; rs35622981; rs35490549; rs11412067; rs35651411; rs185417; rs35939103; rs6884220; rs35476254; rs35234690; rs34662839; rs41405750; rs7713801; rs35584387; rs27169; rs35127834; rs34298707; rs11954741; rs34598563; rs35656102; rs34575207; rs34551750; rs13170793; rs35855221; rs35895437; rs3061409; rs34422101; rs13361043; rs34751449; rs35598166; rs35676156; rs2135480; rs36089178; rs4699936; rs28876414; rs35500271; rs34200989; rs13356176; rs3061708; rs10551360; rs6883912; rs28885736; rs6874847; rs1909296; rs35499758; rs7705352; rs35501358; rs2028841; rs35189950; rs28531774; rs13162317; rs173887; rs35943594; rs35339520; rs13184036; rs2968020; rs34379829; rs34769858; rs722923; rs7735649; rs34233597; rs28369243; rs35329504; rs13186000; rs2607341; rs6873109; rs258116; rs34624326; rs35259546; rs36072354; rs2607348; rs3061467; rs34344560; rs35448373; rs10035396; rs9716593; rs34680701; rs34453807; rs34593368; rs13179144; rs13328098; rs28648858; rs35735511; rs11373971; rs6871100; rs10063724; rs11955117; rs17797035; rs35227733; rs35304; rs7731607; rs17777238; rs36153134; rs34209888; rs33911877; rs13180196; rs258119; rs7713808; rs34533703; rs3061702; rs10040742; rs34501738; rs13158325; rs255656; rs431645; rs13159276; rs11351473; rs190432; rs10062189; rs35516422; rs35073004; rs34862762; rs34468745; rs35509503; rs34768031; rs35587177; rs33941389; rs6869945; rs35243888; rs2968016; rs10633205; rs2055295; rs1143236; rs35453725; rs11348414; rs3061706; rs6450503; rs3061457; rs35943112; rs13347326; rs35868304; rs35959609; rs35147554; rs6895251; rs33922784; rs35913935; rs28705844; rs7705784; rs34217990; rs10581664; rs7444132; rs2174624; rs5868163; rs1838720; rs10052704; rs10573988; rs35692333; rs34507601; rs11280004; rs34873380; rs255460; rs4441841; rs35943702; rs35966656; rs28571683; rs35925966; rs28735903; rs13163857; rs13177851; rs7710901; rs13178378; rs34209564; rs35365611; rs6149041; rs26686; rs34351758; rs35671080; rs6880654; rs154029; rs7710055; rs35190866; rs33949395; rs28490233; rs7735819; rs2607346; rs34621496; rs10070588; rs35836561; rs13187778; rs35343334; rs10471469; rs35526059; rs34709522; rs5868179; rs34649343; rs35231519; rs34555200; rs10699804; rs10041815; rs12188999; rs7737269; rs35954639; rs13181587; rs34314412; rs1506562; rs28508065; rs34879089; rs7737071; rs154220; rs10704376; rs6879049; rs13178988; rs35597897; rs7731419; rs9942415; rs6870989; rs34249657; rs10472095; rs5868168; rs11737993; rs34949154; rs28406753; rs35020719; rs1498607; rs3061415; rs34785566; rs745813; rs34276144; rs5868172; rs7717793; rs34592041; rs36157268; rs6877826; rs34084254; rs35818881; rs34669732; rs35063826; rs1472456; rs35069329; rs34248179; rs35027879; rs5868150; rs35837060; rs13154094; rs10472092; rs28529077; rs1350297; rs11420361; rs6875864; rs35399502; rs34554235; rs34907429; rs36034409; rs4700326; rs11948460; rs35459588; rs35553072; rs35979928; rs36074437; rs11325874; rs11953985; rs34017676; rs28415294; rs36098200; rs166260; rs35505239; rs16888929; rs9292191; rs10044159; rs10052007; rs10658576; rs34876197; rs176705; rs10041861; rs13358675; rs34131200; rs10472096; rs35653778; rs10641798; rs5868173; rs34683467; rs5868154; rs34275268; rs3061615; rs5868181; rs294475; rs34549454; rs35720109; rs35500652; rs34532597; rs34815381; rs166249; rs956180; rs10551181; rs10549903; rs34591489; rs10664902; rs531511; rs153984; rs153647; rs28430615; rs35326955; rs10079932; rs28544243; rs35500676; rs2112911; rs2936192; rs36121052; rs34681204; rs3061414; rs34943144; rs35494444; rs13175289; rs34715930; rs1143229; rs2702370; rs28429524; rs34211584; rs34992012; rs702545; rs11425003; rs34025440; rs34636836; rs4099231; rs35728243; rs7721436; rs13190507; rs34671126; rs34688238; rs34422882; rs12518035; rs531105; rs34206938; rs5868161; rs13181967; rs35194865; rs10085037; rs33953218; rs7709897; rs35838554; rs10434567; rs34521304; rs35496140; rs13177540; rs365223; rs35050580; rs10624686; rs12187491; rs36125698; rs36086955; rs7710053; rs258118; rs10471464; rs10626837; rs12108992; rs4700324; rs34457252; rs34449506; rs34490359; rs3061711; rs10085136; rs1143232; rs28657905; rs10595185; rs34098961; rs34550093; rs33951927; rs33964029; rs4699940; rs7711648; rs35355640; rs11744760; rs12110099; rs2409640; rs33945017; rs7707469; rs33923129; rs35342625; rs255634; rs7725632; rs13164719; rs34249117; rs35218911; rs922436; rs34795725; rs12514095; rs34539185; rs35356120; rs35388375; rs2044419; rs27722; rs1065494; rs528422; rs35473646; rs10587603; rs34797165; rs12522944; rs7443305; rs10641593; rs34734362; rs10717217; rs530656; rs34648106; rs35578341; rs1391652; rs11412476; rs10039838; rs10661060; rs13159605; rs1186170; rs10701223; rs35561822; rs13161215; rs7707404; rs10058671; rs10561334; rs34665636; rs4621516; rs7705360; rs12656432; rs34331472; rs35150172; rs5008690; rs34569783; rs35898879; rs2277013; rs383046; rs35182359; rs10223254; rs11324683; rs13179935; rs34433570; rs34156880; rs5868185; rs36203538; rs7443891; rs10533055; rs13359805; rs295933; rs34818966; rs5868171; rs11740671; rs10472090; rs11412487; rs33920644; rs2306292; rs1974841; rs28505210; rs34029569; rs6894319; rs12521263; rs11738599; rs34389985; rs13360907; rs6860418; rs35697600; rs13161103; rs2607344; rs5868176; rs7713069; rs34116835; rs10061600; rs34917776; rs36029168; rs28430839; rs34730535; rs10044993; rs10554068; rs682823; rs6891238; rs35187858; rs11366994; rs7712717; rs27177; rs10565535; rs16889147; rs12656961; rs28706428; rs7715622; rs611540; rs186079; rs13173458; rs34049029; rs13154123; rs35987304; rs35410510; rs11457080; rs1445951; rs37570; rs36131717; rs11955408; rs34206672; rs924998; rs5868164; rs11745169; rs34793823; rs35543326; rs35971368; rs11354852; rs17628143; rs35338164; rs33989667; rs10472087; rs34415724; rs7714489; rs434183; rs34085161; rs35163676; rs5868156; rs10707669; rs16889662; rs34615918; rs5868153; rs10056025; rs34029709; rs34252655; rs5868183; rs5868159; rs6892851; rs6896215; rs9717124; rs255653; rs35606632; rs28555377; rs28680208; rs1506558; rs11748888; rs34497390; rs11356537; rs6872782; rs34203891; rs6867393; rs1960757; rs34680150; rs7725779; rs28460862; rs34071921; rs35039897; rs6871694; rs34280879; rs36062192; rs34141079; rs1816081; rs35900836; rs35005183; rs13178213; rs34372825; rs34584672; rs34161581; rs34283365; rs7709565; rs34130701; rs2936196; rs34261138; rs9716000; rs258124; rs11447636; rs4379155; rs35516815; rs13162130; rs1870078; rs10461658; rs35251595; rs34842927; rs6890180; rs13158460; rs34183853; rs34298212; rs10076635; rs41447947; rs34297420; rs35948623; rs34729847; rs35112587; rs255458; rs12153416; rs35519507; rs36068157; rs11746769; rs4700320; rs2067346; rs12152794; rs10639186; rs33913249; rs13358027; rs10555061; rs10579840; rs1133158; rs35082015; rs34052142; rs34646492; rs34322052; rs34424874; rs35684548; rs11952286; rs35106150; rs1870076; rs7736448; rs36158560; rs34985394; rs5868169; rs35746970; rs5868166; rs10600245; rs35116914; rs10472100; rs256128; rs34054950; rs1457112; rs28513138; rs28562290; rs35131890; rs258114; rs258113; rs13185873; rs33937382; rs34060150; rs34916796; rs2702374; rs34357376; rs3061418; rs11952118; rs2607342; rs33993022; rs7715325; rs36030058; rs11387250; rs2548039; rs462930; rs35501009; rs34877183; rs10616440; rs35413991; rs35142413; rs35633619; rs36124270; rs10074406; rs34564012; rs34873866; rs13155404; rs34086583; rs34107557; rs34665834; rs34337000; rs10653014; rs10054481; rs34398584; rs34537847; rs34575928; rs10035258; rs10058539; rs10042414; rs34642374; rs28604386; rs6888386; rs13154271; rs6883563; rs12656245; rs5868175; rs6885690; rs12517745; rs13154277; rs35705115; rs35604134; rs10652340; rs28398197; rs466742; rs34265208; rs36014965; rs35585210; rs13186140; rs7341134; rs6450507; rs721784; rs258126; rs2591745; rs13161395; rs10648089; rs2702376; rs40121; rs28540859; rs35963925; rs12187338; rs35952598; rs611541; rs35797347; rs11738575; rs11350151; rs34092633; rs13358942; rs6149042; rs35450986; rs11346574; rs12516263; rs34285029; rs10698730; rs4627950; rs6898408; rs13185996; rs149107; rs7704141; rs34918657; rs11958824; rs7737908; rs10626977; rs35689772; rs34983709; rs35917605; rs1974838; rs10672522; rs10560642; rs11421072; rs3061408; rs35036216; rs35943533; rs12187142; rs10472088; rs11349022; rs11277625; rs34876134; rs10600503; rs7733370; rs35302311; rs10686252; rs34315041; rs36011948; rs185325; rs35273659; rs10556090; rs28660597; rs34506272; rs34254880; rs34072469; rs575045; rs35859105; rs7444519; rs12109436; rs12189022; rs34982318; rs954740; rs34256357; rs13179611; rs11949985; rs11953154; rs35801943; rs34306611; rs28862729; rs1664886; rs35950250; rs34024693; rs7733884; rs11952378; rs13359707; rs11413820; rs36080031; rs5868178; rs11951378; rs13181969; rs33910828; rs34629419; rs5868160; rs441683; rs7715975; rs34908081; rs28694209; rs3061472; rs7356672; rs34856947; rs4551022; rs34711969; rs6888059; rs35274311; rs34353158; rs36019773; rs35964845; rs28539646; rs10472094; rs1138029; rs28666954; rs13357540; rs13158346; rs4279300; rs3060388; rs7445460; rs10562252; rs13167988; rs13186015; rs34031021; rs1065495; rs35457740; rs3061466; rs7728853; rs258115; rs429191; rs13161214; rs7710342; rs36051277; rs10710659; rs5868151; rs1579316; rs6898386; rs34023059; rs10701279; rs10045150; rs34631941; rs11347219; rs9942390; rs35890577; rs34153724; rs28435484; rs6887956; rs34405862; rs35225834; rs11414841; rs34553923; rs34424978; rs1202160; rs10940639; rs10039319; rs6877904; rs36094087; rs7716117; rs28703107; rs13167038; rs35859367; rs35535163; rs5868180; rs34329719; rs34410141; rs13182805; rs1143234; rs35334435; rs34738106; rs7707973; rs35479721; rs9686434; rs35782047; rs13357023; rs35465707; rs6861588; rs9716677; rs1445949; rs28458370; rs11437091; rs12188697; rs694160; rs13171057; rs34683548; rs34220408; rs34129672; rs36013923; rs530284; rs1143235; rs6888675; rs28508224; rs34811771; rs34216373; rs11425439; rs34621078; rs3061713; rs13172552; rs11749523; rs35530997; rs1974837; rs1506560; rs35291504; rs10043736; rs10036938; rs35614028; rs34852844; rs34886659; rs3989118; rs28729916; rs13187814; rs3840338; rs35004795; rs34244304; rs4493634; rs10636912; rs34445163; rs28373501; rs1506559; rs12374472; rs10704375; rs13355311; rs10056445; rs41404047; rs1809012; rs28435556; rs549097; rs35716104; rs35148987; rs34763664; rs2572933; rs13180070; rs13157337; rs35770645; rs11302070; rs10546090; rs829257; rs36047924; rs11451313; rs11402131; rs10057562; rs1006431; rs10069162; rs10071774; rs10077740; rs10471462; rs10472078; rs10472079; rs10472080; rs10491440; rs10491441; rs10491442; rs11740523; rs11950308; rs12653432; rs12655332; rs12655347; rs13173189; rs13173224; rs13177216; rs13177592; rs13185339; rs13190178; rs13190308; rs1395334; rs1498602; rs1498603; rs1498604; rs1498605; rs17439074; rs17775453; rs1948651; rs1995166; rs2279737; rs295943; rs295944; rs295945; rs295946; rs295947; rs296404; rs296405; rs2968017; rs34791515; rs4143654; rs4279299; rs4699934; rs4700319; rs702521; rs702522; rs702524; rs702525; rs702526; rs702527; rs702528; rs7706419

# Metabolic_Enzyme_92_General_References:
8413254; 8797812; 8125310; 9371713; 10913353; 12834813; 14517540

# Metabolic_Enzyme_92_References:
Not Available

# Metabolic_Enzyme_93_ID:
5909

# Metabolic_Enzyme_93_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

# Metabolic_Enzyme_93_Synonyms:
GMP-PDE gamma

# Metabolic_Enzyme_93_Gene_Name:
PDE6G

# Metabolic_Enzyme_93_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit gamma
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII

# Metabolic_Enzyme_93_Number_of_Residues:
87

# Metabolic_Enzyme_93_Molecular_Weight:
9643

# Metabolic_Enzyme_93_Theoretical_pI:
10.16

# Metabolic_Enzyme_93_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  cGMP-specific phosphodiesterase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_93_General_Function:
Not Available

# Metabolic_Enzyme_93_Specific_Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones

# Metabolic_Enzyme_93_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_93_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_93_Pfam_Domain_Function:
PF04868:PDE6_gamma

# Metabolic_Enzyme_93_Signals:
None

# Metabolic_Enzyme_93_Transmembrane_Regions:
None

# Metabolic_Enzyme_93_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_93_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_93_GenBank_ID_Protein:
189703

# Metabolic_Enzyme_93_SwissProt_ID:
CNRG_HUMAN (P18545)

# Metabolic_Enzyme_93_swissprot_Name:
Not Available

# Metabolic_Enzyme_93_Genecard_id:
PDE6G

# Metabolic_Enzyme_93_Geneatlas_id:
PDE6G

# Metabolic_Enzyme_93_hgnc_id:
HGNC:8789

# Metabolic_Enzyme_93_PDB_ID:
Not Available

# Metabolic_Enzyme_93_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_93_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_93_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_93_Gene_Sequence:
>264 bp
ATGAACCTGGAACCGCCCAAGGCTGAGTTCCGGTCAGCCACCAGGGTGGCCGGGGGACCT
GTCACCCCCAGGAAAGGGCCCCCTAAATTTAAGCAGCGACAGACCAGGCAGTTCAAGAGC
AAGCCCCCAAAGAAAGGCGTTCAAGGGTTTGGGGACGACATCCCTGGAATGGAAGGCCTG
GGAACAGACATCACAGTCATCTGCCCTTGGGAGGCCTTCAACCACCTGGAGCTGCACGAG
CTGGCCCAATATGGCATCATCTAG

# Metabolic_Enzyme_93_GenBank_ID_Gene:
M36476

# Metabolic_Enzyme_93_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_93_Locus:
17q25

# Metabolic_Enzyme_93_SNPs:
rs3830068; rs1126818; rs8477; rs8908; rs3432; rs13372; rs11150803; rs7405790; rs7405798; rs7405870; rs1126835; rs12603868; rs7217415; rs7406825; rs11871837; rs7406828; rs8065526; rs11867395; rs12938981; rs11431043; rs7405799; rs34483867; rs35479959; rs36111499; rs7405655; rs12948839; rs3842709; rs12948797; rs35452055; rs12946993; rs12946445; rs2071451; rs34794441; rs35763415; rs11270790; rs8067026; rs7406904; rs34410653; rs8074225; rs35624022; rs7406891; rs12940128; rs12950388; rs11870066; rs8069538; rs8065141; rs11150804; rs11868728; rs34896443; rs35665020; rs35842897; rs6420484; rs6565616; rs6565617; rs7210026; rs7210043; rs7210193; rs7405629; rs7406678; rs7406705; rs7502320; rs7502869; rs9890264; rs9905410; rs9905639; rs9906358; rs9910935

# Metabolic_Enzyme_93_General_References:
2161380; 1965799; 8125719

# Metabolic_Enzyme_93_References:
Not Available

# Metabolic_Enzyme_94_ID:
5910

# Metabolic_Enzyme_94_Name:
Ubiquitin-conjugating enzyme E2 G2

# Metabolic_Enzyme_94_Synonyms:
Ubiquitin-protein ligase G2; Ubiquitin carrier protein G2

# Metabolic_Enzyme_94_Gene_Name:
UBE2G2

# Metabolic_Enzyme_94_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 G2
MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSF
PLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKIL
LSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL

# Metabolic_Enzyme_94_Number_of_Residues:
165

# Metabolic_Enzyme_94_Molecular_Weight:
18566

# Metabolic_Enzyme_94_Theoretical_pI:
4.34

# Metabolic_Enzyme_94_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_94_General_Function:
Not Available

# Metabolic_Enzyme_94_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD)

# Metabolic_Enzyme_94_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_94_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_94_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_94_Signals:
None

# Metabolic_Enzyme_94_Transmembrane_Regions:
None

# Metabolic_Enzyme_94_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_94_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_94_GenBank_ID_Protein:
3004909

# Metabolic_Enzyme_94_SwissProt_ID:
UB2G2_HUMAN (P60604)

# Metabolic_Enzyme_94_swissprot_Name:
Not Available

# Metabolic_Enzyme_94_Genecard_id:
UBE2G2

# Metabolic_Enzyme_94_Geneatlas_id:
UBE2G2

# Metabolic_Enzyme_94_hgnc_id:
HGNC:12483

# Metabolic_Enzyme_94_PDB_ID:
Not Available

# Metabolic_Enzyme_94_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_94_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_94_Subcellular_Location:
Not Available

# Metabolic_Enzyme_94_Gene_Sequence:
>498 bp
ATGGCGGGGACCGCGCTCAAGAGGCTGATGGCCGTGTACAAACAATTAACACTGAATCCT
CCGGAAGGAATTGTAGCAGGCCCCATGAATGAAGAGAACTTTTTTGAATGGGAGGCATTG
ATCATGGGCCCAGAAGACACCTGCTTTGAGTTTGGTGTTTTTCCTGCCATCCTGAGTTTC
CCACTTGATTACCCGTTAAGTCCCCCAAAGATGAGATTTACCTGTGAGATGTTTCATCCC
AACATCTACCCTGATGGGAGAGTCTGCATTTCCATCCTCCACGCCCCAGGCGATGACCCC
CATGGGCTACGAGAGCAGCCGGAGCGGTGGAGTCCTGTGCAGAGTGTGGAGAAGATCCTG
CTGTCGGTGGTGAGCATGCTGGCAGAGCCCAATGACGAAAGTGGAGCTAACGTGGATGCG
TCCAAAATGTGGCGCGATGACCGGGAGCAGTTCTATAAGATTGCCAAGCAGATCGTCCAG
AAGTCTCTGGGACTGTGA

# Metabolic_Enzyme_94_GenBank_ID_Gene:
AF032456

# Metabolic_Enzyme_94_Chromosome_Location:
Not Available

# Metabolic_Enzyme_94_Locus:
Not Available

# Metabolic_Enzyme_94_SNPs:
rs2838677; rs2838689; rs1060564; rs2838678; rs1141; rs2838687; rs235271; rs2838676; rs760431; rs4818975; rs235275; rs11569; rs235356; rs760432; rs8131092; rs9981344; rs7281735; rs235355; rs173097; rs9978131; rs235354; rs9984290; rs8103; rs11908708; rs2838688; rs186848; rs8131444; rs235269; rs235270; rs235267; rs235273; rs235274; rs235268; rs184634; rs13433413; rs17289578; rs4818734; rs13049333; rs235369; rs184633; rs8132961; rs235272; rs235358; rs235359; rs2838683; rs2838686; rs2838681; rs2329900; rs2838679; rs235360; rs2838685; rs2838684; rs235362; rs1368991; rs7364120; rs1109280; rs235361; rs2838682; rs2329899; rs876812; rs3788140; rs235367; rs2294157; rs4239838; rs183518; rs1821431; rs8132011; rs235357; rs11702743; rs235364; rs1347324; rs180317; rs2294158; rs235352; rs235353; rs2838691; rs84188; rs6518204; rs2838690; rs235351; rs4818731; rs3788138; rs2274803; rs8126509; rs9977676; rs235291; rs3179387; rs11545486; rs35242981; rs1071792; rs34837820; rs2570974; rs35406176; rs35546235; rs13052399; rs34048289; rs34361555; rs428428; rs34942803; rs2008604; rs35849580; rs13051414; rs13051406; rs34142774; rs1137677; rs34632868; rs13051415; rs28680339; rs35144858; rs7509916; rs170959; rs12626275; rs11088963; rs34887102; rs36028785; rs11545488; rs35868008; rs28728356; rs3838126; rs235368; rs34716840; rs11391154; rs4569556; rs235365; rs34633573; rs11442914; rs727608; rs35209090; rs11373620; rs35371924; rs28668706; rs11448217; rs4818976; rs235363; rs34662670; rs33935066; rs7510415; rs35437707; rs8133388; rs7510280; rs35933313; rs5844198; rs13051119; rs35627976; rs35453630; rs235366; rs10535511; rs170964; rs173095; rs3788137; rs235350; rs34869097; rs34800103; rs1004997; rs10483079; rs1051331; rs11702874; rs17289745; rs180313; rs2016874; rs2017089; rs2329902; rs235292; rs235293; rs2838673; rs2838674; rs2838675; rs2838692; rs2838693; rs2838694; rs2838695; rs3746969; rs3788132; rs3788133; rs3788134; rs3788135; rs3788136; rs3827259; rs434608; rs4437050; rs4818973; rs4818977; rs657730; rs658657; rs674696; rs733161; rs741948; rs760430; rs8130842; rs8133039; rs8645; rs873301; rs885655; rs885656; rs9984357

# Metabolic_Enzyme_94_General_References:
9693041; 10830953

# Metabolic_Enzyme_94_References:
Not Available

# Metabolic_Enzyme_95_ID:
5911

# Metabolic_Enzyme_95_Name:
ADP-ribose pyrophosphatase, mitochondrial precursor

# Metabolic_Enzyme_95_Synonyms:
ADP-ribose diphosphatase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase; ADP-ribose phosphohydrolase; Nucleoside diphosphate- linked moiety X motif 9; Nudix motif 9

# Metabolic_Enzyme_95_Gene_Name:
NUDT9

# Metabolic_Enzyme_95_Protein_Sequence:
>ADPribose pyrophosphatase, mitochondrial precursor
MAGRLLGKALAAVSLSLALASVTIRSSRCRGIQAFRNSFSSSWFHLNTNVMSGSNGSKEN
SHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNF
SPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKR
DSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQ
KTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLML
EAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL

# Metabolic_Enzyme_95_Number_of_Residues:
350

# Metabolic_Enzyme_95_Molecular_Weight:
39125

# Metabolic_Enzyme_95_Theoretical_pI:
8.45

# Metabolic_Enzyme_95_GO_Classification:
Not Available

# Metabolic_Enzyme_95_General_Function:
Not Available

# Metabolic_Enzyme_95_Specific_Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate

# Metabolic_Enzyme_95_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_95_Reaction:
ADP-ribose + H2O = AMP + D-ribose 5-phosphate

# Metabolic_Enzyme_95_Pfam_Domain_Function:
PF00293:NUDIX

# Metabolic_Enzyme_95_Signals:
1-20

# Metabolic_Enzyme_95_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_95_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_95_EC_Link:
EC 3.6.1.13

# Metabolic_Enzyme_95_GenBank_ID_Protein:
14160858

# Metabolic_Enzyme_95_SwissProt_ID:
NUDT9_HUMAN (Q9BW91)

# Metabolic_Enzyme_95_swissprot_Name:
Not Available

# Metabolic_Enzyme_95_Genecard_id:
NUDT9

# Metabolic_Enzyme_95_Geneatlas_id:
NUDT9

# Metabolic_Enzyme_95_hgnc_id:
HGNC:8056

# Metabolic_Enzyme_95_PDB_ID:
1QVJ

# Metabolic_Enzyme_95_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_95_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_95_Subcellular_Location:
Isoform 1:Mitochondrion

# Metabolic_Enzyme_95_Gene_Sequence:
>1053 bp
ATGGCGGGACGCCTCCTGGGAAAGGCTTTAGCCGCGGTGTCTCTCTCTCTGGCCTTGGCC
TCTGTGACTATCAGGTCCTCGCGCTGCCGCGGCATCCAGGCGTTCAGAAACTCGTTTTCA
TCTTCTTGGTTTCATCTTAATACCAACGTCATGTCTGGTTCTAATGGTTCCAAAGAAAAT
TCTCACAATAAGGCTCGGACGTCTCCTTACCCAGGTTCAAAAGTTGAACGAAGCCAGGTT
CCTAATGAGAAAGTGGGCTGGCTTGTTGAGTGGCAAGACTATAAGCCTGTGGAATACACT
GCAGTCTCTGTCTTGGCTGGACCCAGGTGGGCAGATCCTCAGATCAGTGAAAGTAATTTT
TCTCCCAAGTTTAACGAAAAGGATGGGCATGTTGAGAGAAAGAGCAAGAATGGCCTGTAT
GAGATTGAAAATGGAAGACCGAGAAATCCTGCAGGACGGACTGGACTGGTGGGCCGGGGG
CTTTTGGGGCGATGGGGCCCAAATCACGCTGCAGATCCCATTATAACCAGATGGAAAAGG
GATAGCAGTGGAAATAAAATCATGCATCCTGTTTCTGGGAAGCATATCTTACAATTTGTT
GCAATAAAAAGGAAAGACTGTGGAGAATGGGCAATCCCAGGGGGGATGGTGGATCCAGGA
GAGAAGATTAGTGCCACACTGAAAAGAGAATTTGGTGAGGAAGCTCTCAACTCCTTACAG
AAAACCAGTGCTGAGAAGAGAGAAATAGAGGAAAAGTTGCACAAACTCTTCAGCCAAGAC
CACCTAGTGATATATAAGGGATATGTTGATGATCCTCGAAACACTGATAATGCATGGATG
GAGACAGAAGCTGTGAACTACCATGACGAAACAGGTGAGATAATGGATAATCTTATGCTA
GAAGCTGGAGATGATGCTGGAAAAGTGAAATGGGTGGACATCAATGATAAACTGAAGCTT
TATGCCAGTCACTCTCAATTCATCAAACTTGTGGCTGAGAAACGAGATGCACACTGGAGC
GAGGACTCTGAAGCTGACTGCCATGCGTTGTAG

# Metabolic_Enzyme_95_GenBank_ID_Gene:
AY026252

# Metabolic_Enzyme_95_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_95_Locus:
4q22.1

# Metabolic_Enzyme_95_SNPs:
rs11937770; rs4693163; rs7660018; rs7673763; rs10027786; rs10017282; rs11097154; rs34208894; rs28372776; rs7680878; rs4493500; rs1128060; rs13143153; rs10034240; rs6837468; rs10025902; rs7673045; rs11097155; rs7666886; rs6816562; rs7665109; rs6816563; rs13136775; rs10213468; rs6816224; rs6531994; rs6531997; rs10008963; rs4324526; rs6855378; rs11936844; rs12650763; rs4642210; rs12640894; rs10015443; rs7668956; rs28624955; rs13104303; rs7690728; rs13119333; rs9994244; rs13130945; rs7660608; rs9654160; rs7665115; rs13122902; rs10035024; rs12651034; rs6531995; rs12498189; rs11935226; rs11945232; rs11936545; rs6844206; rs28372775; rs35647956; rs34378436; rs13143137; rs13136486; rs35385711; rs35766207; rs28516874; rs35340619; rs13151503; rs34532341; rs35703219; rs33962420; rs7681421; rs28439403; rs10030035; rs6842852; rs13134914; rs35991122; rs13129115; rs9995987; rs28493315; rs35968928; rs10155178; rs28502849; rs34908201; rs35914458; rs28736552; rs10002390; rs28762371; rs11398519; rs6148559; rs35889524; rs35974628; rs35045058; rs10553683; rs7677249; rs34022733; rs34893260; rs11321653; rs35763051; rs28712618; rs6827567; rs11408760; rs6829145; rs35132503; rs7674852; rs7688288; rs33947753; rs13145111; rs4693817; rs35076796; rs28437709; rs9654159; rs35991708; rs11310721; rs35050437; rs34737452; rs35679067; rs34006658; rs35607673; rs28529046; rs13124614; rs35652878; rs28535549; rs35738171; rs35189488; rs35137978; rs11938995; rs34764635; rs34861438; rs34248291; rs11097156; rs33924039; rs9999899; rs35766329; rs5860073; rs34697941; rs34367002; rs34414336; rs28493566; rs9998212; rs35649088; rs34596563; rs35531610; rs13115687; rs35364531; rs34608747; rs36055576; rs28609242; rs28406846; rs35227897; rs10084883; rs6831350; rs6831120; rs10009948; rs10013990; rs10017783; rs10024099; rs10032572; rs11936273; rs11936366; rs11947959; rs12503328; rs12640451; rs12648606; rs12651667; rs13111348; rs13133003; rs34485767; rs4314250; rs4364226; rs4405983; rs6531988; rs6531990; rs6818444; rs6825532; rs6826257; rs6833270; rs6833835; rs6838776; rs6839314; rs6854710; rs7691533; rs9307036; rs9968511; rs9990749; rs9998007; rs9998122

# Metabolic_Enzyme_95_General_References:
11385575; 12975309

# Metabolic_Enzyme_95_References:
Not Available

# Metabolic_Enzyme_96_ID:
5237

# Metabolic_Enzyme_96_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_96_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_96_Gene_Name:
NT5C2

# Metabolic_Enzyme_96_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_96_Number_of_Residues:
561

# Metabolic_Enzyme_96_Molecular_Weight:
64970

# Metabolic_Enzyme_96_Theoretical_pI:
6.05

# Metabolic_Enzyme_96_GO_Classification:
Not Available

# Metabolic_Enzyme_96_General_Function:
Not Available

# Metabolic_Enzyme_96_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_96_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_96_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_96_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_96_Signals:
None

# Metabolic_Enzyme_96_Transmembrane_Regions:
None

# Metabolic_Enzyme_96_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_96_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_96_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_96_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_96_swissprot_Name:
Not Available

# Metabolic_Enzyme_96_Genecard_id:
NT5C2

# Metabolic_Enzyme_96_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_96_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_96_PDB_ID:
Not Available

# Metabolic_Enzyme_96_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_96_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_96_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_96_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_96_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_96_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_96_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_96_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_96_General_References:
7999131

# Metabolic_Enzyme_96_References:
Not Available

# Metabolic_Enzyme_97_ID:
5912

# Metabolic_Enzyme_97_Name:
Adenosine kinase

# Metabolic_Enzyme_97_Synonyms:
AK; Adenosine 5'-phosphotransferase

# Metabolic_Enzyme_97_Gene_Name:
ADK

# Metabolic_Enzyme_97_Protein_Sequence:
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

# Metabolic_Enzyme_97_Number_of_Residues:
362

# Metabolic_Enzyme_97_Molecular_Weight:
40546

# Metabolic_Enzyme_97_Theoretical_pI:
6.67

# Metabolic_Enzyme_97_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  adenosine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_97_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_97_Specific_Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides

# Metabolic_Enzyme_97_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_97_Reaction:
ATP + adenosine = ADP + AMP

# Metabolic_Enzyme_97_Pfam_Domain_Function:
PF00294:PfkB

# Metabolic_Enzyme_97_Signals:
None

# Metabolic_Enzyme_97_Transmembrane_Regions:
None

# Metabolic_Enzyme_97_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_97_EC_Link:
EC 2.7.1.20

# Metabolic_Enzyme_97_GenBank_ID_Protein:
1224125

# Metabolic_Enzyme_97_SwissProt_ID:
ADK_HUMAN (P55263)

# Metabolic_Enzyme_97_swissprot_Name:
Not Available

# Metabolic_Enzyme_97_Genecard_id:
ADK

# Metabolic_Enzyme_97_Geneatlas_id:
ADK

# Metabolic_Enzyme_97_hgnc_id:
HGNC:257

# Metabolic_Enzyme_97_PDB_ID:
1BX4

# Metabolic_Enzyme_97_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_97_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_97_Subcellular_Location:
Not Available

# Metabolic_Enzyme_97_Gene_Sequence:
>1038 bp
ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCT
GCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTG
GCTGAAGACAAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATAT
CATGCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCA
CACAAAGCAGCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAG
AGAAAAGCTGCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACA
GGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCT
GCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAA
AAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTCACGTTTCCCCAGAGTCAGTATTA
AAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCG
TTTATTAGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTT
TTTGGAAATGAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGAC
ATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGA
ATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGAT
GCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATC
CGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGA

# Metabolic_Enzyme_97_GenBank_ID_Gene:
U50196

# Metabolic_Enzyme_97_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_97_Locus:
10q22|10q11-q24

# Metabolic_Enzyme_97_SNPs:
rs16931480; rs1189553; rs10824095; rs2169682; rs2894236; rs1904060; rs1904067; rs1904066; rs1871088; rs1908335; rs719624; rs1871085; rs1871087; rs2894234; rs1904064; rs871267; rs10824166; rs7350403; rs10824172; rs7090732; rs10824087; rs7894466; rs2395096; rs1898057; rs6480741; rs10740440; rs6480745; rs7098277; rs10509348; rs7079515; rs7909197; rs7899674; rs6480721; rs11597563; rs10740439; rs4451661; rs1898055; rs7079633; rs2126768; rs4390292; rs10824163; rs6480734; rs7083427; rs2169683; rs2395092; rs7072264; rs7092245; rs7922519; rs4746191; rs10824183; rs10762587; rs7100452; rs7094239; rs4564273; rs1898056; rs7096553; rs4237279; rs7087566; rs11000920; rs10762595; rs7068789; rs7100550; rs6480733; rs10762582; rs4323810; rs7098200; rs2306161; rs10824170; rs7084786; rs10824165; rs10762621; rs7923414; rs10824182; rs7916445; rs6480742; rs7082003; rs961321; rs10762624; rs10824094; rs7093532; rs7908160; rs2395095; rs6480749; rs4320897; rs10762606; rs9665468; rs10733903; rs10762601; rs11001022; rs10824133; rs10824119; rs4077282; rs10509350; rs10762640; rs4746181; rs10824195; rs7918318; rs4459229; rs6480739; rs4261231; rs10762605; rs7082872; rs3862535; rs6480727; rs7918927; rs2395087; rs10824120; rs10824186; rs7078351; rs7087368; rs7914902; rs4746214; rs1904061; rs11001105; rs10762615; rs7083534; rs10824177; rs7085940; rs10740437; rs4746182; rs10740436; rs11001043; rs2126760; rs11818050; rs6480726; rs10762612; rs7895133; rs7075643; rs7095850; rs10740443; rs4746221; rs10824185; rs4353215; rs2395097; rs2126763; rs7924176; rs7910153; rs7919277; rs7072220; rs10762636; rs10762622; rs11000931; rs4745739; rs3781255; rs10762588; rs10824138; rs10824218; rs10762638; rs2126765; rs6480731; rs4745749; rs4338470; rs7074939; rs7079709; rs4746207; rs7921187; rs11819334; rs11000960; rs11001089; rs4561146; rs11815260; rs10824193; rs10762629; rs10824135; rs7917790; rs10824105; rs11597376; rs11817779; rs7897750; rs11593868; rs4746216; rs7919166; rs11001052; rs12573619; rs10762620; rs10824197; rs7071324; rs10762596; rs11816566; rs7912162; rs7072504; rs11813905; rs10824161; rs2126767; rs10762603; rs10733895; rs7097320; rs11813953; rs7072012; rs10824122; rs7909915; rs12573590; rs4746177; rs10762639; rs726120; rs10824188; rs7913606; rs4745743; rs10740423; rs11001020; rs7075393; rs4746212; rs7923626; rs4746190; rs1556822; rs946186; rs7899920; rs10762630; rs10824134; rs12784355; rs16931294; rs2117791; rs2078036; rs12571088; rs10762607; rs10824192; rs10824137; rs11001028; rs7477710; rs10824098; rs946185; rs11814981; rs11001046; rs7916143; rs6480732; rs4745750; rs7914995; rs10509347; rs7069460; rs10740441; rs7075956; rs10762591; rs4376843; rs4281434; rs10824208; rs7901031; rs11000964; rs11818752; rs10824101; rs7099494; rs1904062; rs10762635; rs11813032; rs10824106; rs10824160; rs2126766; rs11001002; rs10762611; rs11000925; rs6480724; rs10762599; rs16931395; rs11000911; rs7917666; rs7896617; rs11816554; rs11000939; rs958620; rs12416316; rs10762641; rs10824130; rs7073742; rs12355686; rs11813815; rs2164367; rs11001109; rs9665469; rs7098337; rs10824124; rs10762619; rs10824092; rs1904065; rs12772532; rs10824174; rs7901055; rs4639878; rs1556821; rs11814426; rs6480723; rs12360119; rs10824152; rs11813920; rs10824164; rs7073340; rs10824143; rs10824103; rs4489684; rs10824210; rs12570185; rs16931536; rs1993861; rs10824151; rs12571589; rs16931460; rs11001005; rs10824144; rs7923592; rs11598232; rs10762626; rs10824128; rs10762581; rs7084139; rs1556820; rs1904058; rs10509351; rs7100084; rs11000924; rs11001018; rs12569971; rs7895587; rs2395078; rs12416497; rs10762631; rs11001053; rs11814705; rs11814063; rs10762593; rs9971034; rs16931332; rs11815536; rs11001111; rs11001007; rs4746196; rs7920097; rs16931462; rs7097778; rs12573807; rs11001099; rs11001092; rs11813221; rs7073139; rs11001034; rs12572721; rs10824102; rs1904063; rs11001004; rs10824108; rs10509349; rs10824194; rs10733904; rs10740432; rs6480740; rs3862536; rs12573198; rs7896660; rs11000922; rs10762600; rs7089391; rs12412109; rs10824096; rs10824153; rs7476181; rs11001047; rs6480729; rs10740420; rs4746192; rs7896152; rs7906603; rs7894143; rs10824221; rs2894235; rs10762608; rs7086014; rs10824129; rs11001096; rs7915999; rs7902519; rs4746188; rs11812862; rs2131955; rs2126769; rs6480722; rs11598022; rs10824146; rs10824090; rs12415957; rs11812826; rs12412071; rs4745751; rs7084204; rs7087290; rs13376718; rs10762577; rs7914783; rs10824154; rs12243059; rs7088329; rs11001029; rs11000921; rs10762586; rs1908333; rs11000928; rs7905039; rs35074621; rs12357589; rs11000948; rs10740431; rs11000997; rs11001006; rs7895292; rs11812696; rs12573068; rs11000914; rs7089625; rs7081350; rs7074449; rs11001045; rs4501938; rs7922635; rs7898073; rs7903786; rs10762637; rs12220238; rs12251845; rs12217890; rs12259556; rs6480748; rs11001115; rs16931364; rs11001059; rs10762583; rs11000899; rs11000966; rs10762613; rs4746194; rs4341485; rs6480744; rs9664463; rs12261738; rs12360399; rs12572648; rs7919517; rs11001102; rs10128407; rs10824097; rs11001085; rs12360087; rs4746180; rs6480728; rs12573347; rs11001014; rs11594742; rs11000977; rs10824107; rs10824198; rs11599616; rs10824147; rs16931492; rs10824212; rs4615968; rs12268556; rs11000996; rs4745738; rs12359456; rs16931504; rs11001003; rs956118; rs12415743; rs12261586; rs7091715; rs12356618; rs11001114; rs1871086; rs12241337; rs12569368; rs11001103; rs10740421; rs6480730; rs9299518; rs7900243; rs10824117; rs12254109; rs4746189; rs7897539; rs10762585; rs11000951; rs10824113; rs10824104; rs16931528; rs11817059; rs4745744; rs16931523; rs11597443; rs10824148; rs16931525; rs16931367; rs11000988; rs10762602; rs6480746; rs7905536; rs10762618; rs12256590; rs7069107; rs10824142; rs12098284; rs7091719; rs11819665; rs11000959; rs7091300; rs11819705; rs16931516; rs12252558; rs16931474; rs7919010; rs10824123; rs7913178; rs11000909; rs11000915; rs12243409; rs12572696; rs7920185; rs7897778; rs12569733; rs7067813; rs4746198; rs7096664; rs16931341; rs7094284; rs7903760; rs11000945; rs11001015; rs7088944; rs7897643; rs1908334; rs10824111; rs12415794; rs11001090; rs12217753; rs11591270; rs16931520; rs4745740; rs7088149; rs11000927; rs4746202; rs7076721; rs16931511; rs9651336; rs16931546; rs12779371; rs7902089; rs12569695; rs12253120; rs9664464; rs946184; rs10824116; rs10762614; rs12416580; rs4746209; rs11598266; rs4746210; rs7921832; rs16931468; rs11818734; rs10824169; rs11000992; rs7085860; rs11000936; rs11819396; rs4331029; rs10824136; rs10740442; rs1416101; rs10762594; rs11812834; rs12569856; rs12775658; rs10824171; rs7904939; rs10824140; rs7073432; rs16931449; rs12268312; rs10824110; rs11001112; rs11001078; rs7073227; rs10824099; rs12414029; rs4745747; rs7920006; rs4745745; rs12260506; rs12359289; rs12415761; rs11000990; rs11001087; rs4341483; rs11814484; rs11817882; rs11000901; rs11000980; rs11000946; rs12355188; rs7901569; rs10824112; rs10824100; rs16931465; rs10824149; rs2395091; rs10430473; rs11595136; rs11000999; rs10824109; rs10824168; rs1531; rs10430521; rs4745741; rs12242776; rs7895061; rs12773903; rs10762598; rs10824209; rs7905662; rs11815035; rs12354678; rs10824220; rs12098289; rs4746197; rs11000994; rs7099552; rs7069901; rs11000912; rs7071823; rs10824175; rs7083605; rs4746187; rs12569670; rs12356350; rs7918573; rs10824115; rs10824181; rs12570624; rs7092741; rs10824203; rs11819074; rs11001031; rs7910626; rs12415736; rs10762609; rs11001027; rs12268597; rs11001016; rs4746218; rs12570022; rs11000941; rs11000986; rs10824139; rs7086415; rs12354659; rs17747401; rs2126764; rs11599320; rs12414489; rs7080815; rs10824118; rs10824091; rs7901524; rs11812815; rs12572580; rs16931477; rs10762584; rs7904489; rs4745752; rs7906759; rs12572155; rs7084146; rs11516630; rs7901242; rs11001013; rs7074327; rs4746215; rs7898517; rs10824088; rs10824167; rs10824125; rs10824132; rs10824141; rs11599829; rs11000962; rs11594739; rs10824121; rs11813394; rs12357370; rs11000900; rs7904773; rs10824211; rs10762589; rs11000947; rs7091823; rs12252705; rs11000981; rs7087567; rs11001048; rs16931519; rs7918003; rs16931521; rs7085334; rs12265663; rs10762617; rs16931527; rs11001116; rs12411935; rs12779309; rs4746211; rs7898405; rs12242814; rs10762592; rs10762616; rs11001019; rs10430474; rs2395093; rs10824202; rs1538311; rs10824114; rs10740433; rs12573649; rs7907801; rs1529; rs11000934; rs10824150; rs10740438; rs16931538; rs11001001; rs7081573; rs11817959; rs11000987; rs7907267; rs6480743; rs7906779; rs11819130; rs16931490; rs10824190; rs2169684; rs11001008; rs11000954; rs11000916; rs7894697; rs16931472; rs1189552; rs2126762; rs1052039; rs28433006; rs12767624; rs10709030; rs7476928; rs10699958; rs35967107; rs4328165; rs12256125; rs35681751; rs6480750; rs34148029; rs35946213; rs34428151; rs36030657; rs34269690; rs3037403; rs28806480; rs34213308; rs35291653; rs12265290; rs10587775; rs11001010; rs10400100; rs5786147; rs35242280; rs34546969; rs35683991; rs10618104; rs34215048; rs35938247; rs768959; rs12769918; rs36029311; rs7909834; rs11000950; rs35036011; rs33912244; rs4746184; rs4369336; rs11000973; rs35746333; rs2027266; rs12264178; rs12768982; rs5786138; rs11427369; rs36100829; rs34310248; rs34469098; rs11470196; rs11000993; rs11310691; rs35270154; rs7392652; rs35240931; rs11001076; rs34868542; rs35677795; rs12253997; rs11001024; rs11361618; rs34483117; rs1016419; rs11001062; rs35389691; rs4746213; rs12770163; rs12242773; rs12250065; rs714446; rs7478561; rs11000983; rs35213595; rs35124446; rs12360425; rs11001041; rs7101087; rs12768640; rs34991446; rs11001107; rs34157587; rs34960972; rs11001063; rs6143984; rs11001033; rs10824216; rs7068038; rs11000963; rs12769277; rs12221297; rs34006036; rs35913987; rs35593805; rs11000958; rs35690083; rs12776428; rs12359909; rs35675013; rs34160937; rs17682987; rs11298231; rs28665887; rs34822835; rs10693309; rs12358321; rs11294383; rs35382240; rs11441752; rs11000932; rs3192342; rs10443948; rs34368934; rs16931389; rs4746219; rs7085007; rs16931551; rs12784339; rs34785655; rs35885564; rs34253447; rs34545592; rs35474264; rs35954951; rs12261116; rs1871083; rs4746220; rs12769928; rs35213605; rs34146097; rs11001025; rs1904059; rs35282438; rs34630297; rs35244559; rs36064398; rs12772349; rs35081895; rs10719538; rs12358053; rs12770150; rs10824219; rs4578321; rs11812645; rs11000944; rs11377985; rs9730888; rs11001039; rs35189522; rs11377715; rs10578956; rs12245560; rs11464387; rs11001088; rs1908336; rs2395089; rs11000918; rs7478196; rs11001093; rs35289591; rs35155141; rs10630238; rs11000935; rs11283273; rs11431842; rs11498031; rs12241229; rs12779690; rs35621346; rs35957820; rs11516631; rs35088225; rs28540400; rs35958238; rs3758511; rs11427347; rs35956325; rs11000905; rs12780859; rs34456914; rs12257326; rs11000910; rs2951091; rs11419041; rs35418682; rs35969519; rs34509827; rs34011472; rs11001073; rs13376894; rs16931407; rs11001066; rs3037448; rs34427535; rs12359976; rs11285474; rs28756681; rs34190731; rs11292901; rs34798510; rs12775686; rs7076019; rs12571515; rs35698592; rs10568623; rs7079178; rs35634749; rs35197598; rs11000998; rs34848917; rs7070345; rs35336446; rs35924345; rs34395307; rs35681211; rs34203173; rs7074078; rs11000949; rs12251148; rs11294980; rs34484828; rs7070707; rs5786139; rs35196181; rs7909032; rs34729493; rs34311007; rs35676834; rs34350496; rs35653353; rs35343842; rs35944635; rs34770422; rs35567434; rs11592151; rs34334128; rs4746208; rs12217863; rs12776780; rs10710680; rs34328974; rs11354070; rs35548449; rs35138612; rs11000937; rs5786136; rs34975658; rs11001051; rs5786148; rs12768637; rs12776762; rs11001032; rs35565783; rs35141788; rs5786145; rs34381749; rs34206298; rs16931588; rs11000972; rs34606636; rs35192408; rs11313699; rs11819453; rs12257167; rs35322063; rs34758567; rs11394734; rs4746193; rs34040400; rs12416047; rs7100239; rs35010757; rs11001050; rs35043540; rs35574014; rs35285241; rs12769920; rs11001077; rs35801937; rs9888065; rs12572719; rs12776511; rs11446202; rs11001023; rs4400738; rs34865824; rs3837336; rs12771556; rs35658711; rs11001042; rs9732237; rs34077396; rs12781732; rs12268885; rs16931430; rs34241739; rs11527234; rs11818880; rs12250504; rs12771964; rs4746185; rs11310513; rs7074915; rs35543329; rs7088493; rs34445084; rs12414124; rs10631417; rs35870828; rs35153697; rs12570068; rs2126761; rs11000976; rs12259418; rs35120068; rs34312133; rs4589228; rs34043389; rs34232307; rs11000965; rs34313197; rs12261108; rs12267421; rs35345171; rs12781539; rs1898054; rs34844657; rs12244479; rs11000933; rs12770253; rs1832436; rs35239000; rs4639879; rs35111858; rs11313781; rs12146408; rs7099493; rs36104559; rs12573253; rs12767938; rs34722640; rs35137924; rs35527525; rs35650817; rs34057132; rs34149159; rs11463660; rs11598404; rs2027265; rs41280418; rs34554027; rs12772421; rs11001068; rs11000961; rs10554301; rs11001113; rs10400099; rs35788249; rs11001074; rs11001049; rs35392498; rs11001079; rs11381604; rs34757853; rs11000984; rs10633386; rs28367539; rs35193175; rs5786149; rs36126508; rs11367583; rs34369353; rs12262949; rs35927711; rs949720; rs12769308; rs11001106; rs9733631; rs34985864; rs11527423; rs11289206; rs2894237; rs11320887; rs35035527; rs10596248; rs34829852; rs35566961; rs35148425; rs12259513; rs2395088; rs12777975; rs11001055; rs7078624; rs4746217; rs35385535; rs34440443; rs5786151; rs35822474; rs7478047; rs34684326; rs34778804; rs9731072; rs34447904; rs11458497; rs11361273; rs34029062; rs34301605; rs34969882; rs35062545; rs34668568; rs11596973; rs35067531; rs11000971; rs11000919; rs35038709; rs34848555; rs34943780; rs12775085; rs13376895; rs28550755; rs35630116; rs35480343; rs12358427; rs7476100; rs11001054; rs7916584; rs34117712; rs10646695; rs11001060; rs34025605; rs12782778; rs11000989; rs10550667; rs11001094; rs12254751; rs11001083; rs10592912; rs11001081; rs7914846; rs11001069; rs7083128; rs12771949; rs35844167; rs34807188; rs35351336; rs28798394; rs34628857; rs34464248; rs10653576; rs34498680; rs16931301; rs34644210; rs35318416; rs12357530; rs4506580; rs28886966; rs11527424; rs28711776; rs35836498; rs34575360; rs35138837; rs36106558; rs2894238; rs35333397; rs34945364; rs12261051; rs10546914; rs28705900; rs11000930; rs34022905; rs34369612; rs5786140; rs12415282; rs11001117; rs11451786; rs34788425; rs7476538; rs11000956; rs5786137; rs11000923; rs35465617; rs11001012; rs12355952; rs12267197; rs4303177; rs12254040; rs36070427; rs12770467; rs11000952; rs2027268; rs34323155; rs3037396; rs35856088; rs35278865; rs12357643; rs35046845; rs11434396; rs34777095; rs11597052; rs10667574; rs12763748; rs12414280; rs34427766; rs11498032; rs3037400; rs35287036; rs35285709; rs10710237; rs4746186; rs3037446; rs41405146; rs4746179; rs36119808; rs7072529; rs35194075; rs7094743; rs11300921; rs11000957; rs35630271; rs34844177; rs11597340; rs35918774; rs35774493; rs11599870; rs34794280; rs16931444; rs34535203; rs36041609; rs35654646; rs11357215; rs34600695; rs35167424; rs11000991; rs12764263; rs28620392; rs12765352; rs34417435; rs35499084; rs5786150; rs12771367; rs34006665; rs3957133; rs11000967; rs34878578; rs35302558; rs12255237; rs2395090; rs12098843; rs12220218; rs35091445; rs12251416; rs12764980; rs11598353; rs34605650; rs36016023; rs10693107; rs11596436; rs11000985; rs11492360; rs7100311; rs35008670; rs11001064; rs11000979; rs11001058; rs35705914; rs35798713; rs34320598; rs35102669; rs7090447; rs12261107; rs34385041; rs12267892; rs11593990; rs34053466; rs11312116; rs34287044; rs12767472; rs12359775; rs34820269; rs35056778; rs11000926; rs34396421; rs12355723; rs7083096; rs34992970; rs34064444; rs11000907; rs11001038; rs10578552; rs35152713; rs35733476; rs34480841; rs11001009; rs2395094; rs12775961; rs10558951; rs5786142; rs17744431; rs35872639; rs35658993; rs10535419; rs35203634; rs16931563; rs35781747; rs34577685; rs7082866; rs10527692; rs35945477; rs10565601; rs12248996; rs10657653; rs16931425; rs10612340; rs11000942; rs28673867; rs11001011; rs35803794; rs11000975; rs11380814; rs7093745; rs12782355; rs35927517; rs1140726; rs12262204; rs11000929; rs2027267; rs6480747; rs12247758; rs35796098; rs28457756; rs11000917; rs28599671; rs12767217; rs34601191; rs17746699; rs12098261; rs12255345; rs12250748; rs36073830; rs11297052; rs34377885; rs35708858; rs34454856; rs12241160; rs10669118; rs34336674; rs34920875; rs11001070; rs12415222; rs35421202; rs35759508; rs35249335; rs34947578; rs10400203; rs35521667; rs34161719; rs5786141; rs730660; rs11383205; rs34975150; rs2927517; rs7087005; rs11001021; rs3998213; rs12783210; rs35081179; rs10536957; rs34761801; rs11317030; rs11597174; rs35949478; rs7899397; rs12783738; rs17685047; rs11311986; rs35070470; rs28583797; rs35998695; rs11001095; rs12768800; rs34632561; rs7358249; rs34610545; rs719944; rs10559831; rs34130571; rs34419004; rs34492397; rs35960706; rs11000902; rs16931508; rs12356357; rs35369268; rs35568529; rs11000978; rs11368451; rs7909196; rs11596716; rs11591337; rs10612480; rs10710238; rs35423162; rs36067412; rs35503260; rs11001071; rs35720770; rs4746183; rs35744043; rs12250637; rs4448625; rs4746206; rs12772768; rs11377208; rs12781289; rs34033009; rs34705543; rs12770119; rs12261147; rs11510969; rs35092600; rs35989197; rs34809429; rs11001061; rs28588347; rs11356202; rs4745746; rs12221444; rs34137547; rs10534993; rs12765322; rs34589243; rs28891140; rs35036906; rs5786146; rs7101010; rs35057058; rs12763083; rs12241919; rs35010094; rs35210704; rs11001108; rs1131988; rs12776754; rs12764241; rs11285475; rs35913612; rs12773960; rs11000995; rs11279355; rs34842035; rs11592294; rs12219767; rs35370125; rs35785348; rs34133995; rs12243218; rs34631179; rs12763766; rs34123435; rs12251389; rs35116974; rs35655878; rs35281622; rs35717142; rs35955774; rs12249241; rs34740358; rs12261563; rs11492299; rs12767200; rs34775607; rs34490010; rs36042076; rs11447835; rs35273093; rs11402306; rs11814352; rs11388849; rs12241943; rs28422778; rs10689388; rs11000982; rs11597668; rs35085839; rs11278279; rs34137673; rs11001104; rs11000974; rs11001080; rs34027811; rs5786143; rs35689397; rs7898976; rs35973082; rs11001017; rs35190282; rs34346566; rs12775960; rs12769919; rs12267534; rs12251369; rs7071553; rs10698256; rs34893135; rs28612186; rs35236497; rs28842181; rs35388074; rs11000943; rs7081474; rs34535580; rs12269424; rs10682966; rs10670267; rs11000968; rs34357111; rs34359934; rs11001075; rs16931359; rs12356967; rs35233016; rs11001030; rs12255362; rs11372723; rs4638258; rs4341484; rs16931393; rs11001086; rs11000913; rs12243374; rs4745742; rs34770607; rs12778270; rs34660792; rs11000906; rs11001026; rs28473266; rs4746200; rs7089267; rs12764238; rs11001037; rs12359146; rs3837337; rs1051938; rs1051939; rs10824083; rs10824085; rs10824086; rs11000888; rs11000889; rs11000892; rs11000893; rs11000894; rs11000897; rs11817132; rs1189549; rs1189550; rs1189551; rs12256105; rs12358614; rs12572479; rs12778712; rs1338389; rs1766711; rs1766713; rs17676126; rs1774692; rs1871084; rs1874147; rs1908330; rs2788148; rs2894228; rs3812639; rs3829129; rs4638254; rs4746176; rs6480720; rs7071701; rs7079959; rs7099159; rs733350; rs7896323

# Metabolic_Enzyme_97_General_References:
8577746; 8917457; 9070863; 9843365; 12112843

# Metabolic_Enzyme_97_References:
Not Available

# Metabolic_Enzyme_98_ID:
5715

# Metabolic_Enzyme_98_Name:
Hypoxanthine-guanine phosphoribosyltransferase

# Metabolic_Enzyme_98_Synonyms:
HGPRT; HGPRTase

# Metabolic_Enzyme_98_Gene_Name:
HPRT1

# Metabolic_Enzyme_98_Protein_Sequence:
>Hypoxanthineguanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

# Metabolic_Enzyme_98_Number_of_Residues:
218

# Metabolic_Enzyme_98_Molecular_Weight:
24580

# Metabolic_Enzyme_98_Theoretical_pI:
6.67

# Metabolic_Enzyme_98_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
Function:  hypoxanthine phosphoribosyltransferase activity
 ||
>>>
Process:  nucleoside metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_98_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_98_Specific_Function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_98_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_98_Reaction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

# Metabolic_Enzyme_98_Pfam_Domain_Function:
PF00156:Pribosyltran

# Metabolic_Enzyme_98_Signals:
None

# Metabolic_Enzyme_98_Transmembrane_Regions:
None

# Metabolic_Enzyme_98_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_98_EC_Link:
EC 2.4.2.8

# Metabolic_Enzyme_98_GenBank_ID_Protein:
306885

# Metabolic_Enzyme_98_SwissProt_ID:
HPRT_HUMAN (P00492)

# Metabolic_Enzyme_98_swissprot_Name:
Not Available

# Metabolic_Enzyme_98_Genecard_id:
HPRT1

# Metabolic_Enzyme_98_Geneatlas_id:
HPRT1

# Metabolic_Enzyme_98_hgnc_id:
HGNC:5157

# Metabolic_Enzyme_98_PDB_ID:
1BZY

# Metabolic_Enzyme_98_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_98_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_98_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_98_Gene_Sequence:
>657 bp
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA

# Metabolic_Enzyme_98_GenBank_ID_Gene:
M31642

# Metabolic_Enzyme_98_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_98_Locus:
Xq26.1

# Metabolic_Enzyme_98_SNPs:
rs17882614; rs17324664; rs1468266; rs6638240; rs6638244; rs629; rs12687175; rs2070888; rs17882706; rs17879768; rs6638243; rs6634993; rs2283774; rs2515695; rs17324671; rs17000619; rs17879343; rs17881098; rs17883992; rs17882148; rs6634992; rs17885981; rs17879832; rs17879883; rs17882974; rs17879054; rs6654281; rs17885745; rs17878776; rs17885116; rs17882408; rs17883944; rs17879655; rs17879788; rs17885487; rs17879062; rs12383909; rs17882655; rs6638248; rs17879889; rs6638241; rs17880246; rs17879587; rs12008402; rs17885587; rs17879537; rs17885351; rs17879338; rs17886003; rs17884897; rs17879126; rs17884671; rs17878519; rs17885249; rs17878726; rs17882575; rs630; rs17879579; rs17885481; rs17882577; rs17882724; rs17880173; rs17882449; rs17878366; rs17883719; rs17882059; rs17885063; rs17878341; rs17885117; rs17882713; rs17882954; rs17878494; rs17882387; rs17879006; rs17886404; rs17879389; rs17885867; rs17883942; rs17878843; rs17885455; rs17882760; rs17884775; rs6634990; rs6634995; rs17878582; rs17878883; rs17882358; rs17879110; rs17881011; rs35095771; rs41299094; rs17879494; rs17878772; rs11369747; rs12839009; rs17880167; rs17882944; rs17881023; rs374290; rs35009311; rs17883755; rs12861067; rs17882363; rs34425749; rs34838035; rs366687; rs6638242; rs17879610; rs28478865; rs17887208; rs405630; rs12380958; rs5903878; rs17878547; rs35869442; rs387714; rs35585686; rs6634994; rs17882487; rs17879085; rs5978009; rs5933415; rs17883196; rs116493; rs5933416; rs12836923; rs12381664; rs35238558; rs17882186; rs373901; rs35653185; rs17881003; rs6638245; rs35325865; rs35834777; rs11406107; rs17884978; rs17885259; rs17882884; rs17883708; rs12836918; rs391918; rs34619253; rs377106; rs35538011; rs17884910; rs398712; rs5933414; rs35832135; rs17885490; rs12381784; rs377103; rs5903877; rs17880051; rs12838998; rs17878536; rs11344152; rs2503983; rs36109224; rs17884854; rs17878792; rs17878589; rs7472760; rs28663133; rs117407; rs17881034; rs12381662; rs17886030; rs6638246; rs17885101; rs17879848; rs17879532; rs17882283; rs417522; rs17878403; rs414365; rs5978007; rs398716; rs7357883; rs10482430; rs12689866; rs12847109; rs437849; rs4829768; rs6634997; rs6638238

# Metabolic_Enzyme_98_General_References:
6300847; 2341149; 7107641; 3023844; 8044844; 10360366; 10338013; 1487231; 6853490; 6853716; 6572373; 6706936; 3358423; 3384338; 3265398; 2896620; 3198771; 3148064; 2572141; 2909537; 2910902; 2738157; 2928313; 2347587; 2358296; 2246854; 2018042; 2071157; 1937471; 1840476; 1551676; 1301916; 7627191; 9003484; 9452051

# Metabolic_Enzyme_98_References:
Not Available

# Metabolic_Enzyme_99_ID:
5913

# Metabolic_Enzyme_99_Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

# Metabolic_Enzyme_99_Synonyms:
GMP-PDE delta; p17 protein

# Metabolic_Enzyme_99_Gene_Name:
PDE6D

# Metabolic_Enzyme_99_Protein_Sequence:
>Retinal rod rhodopsinsensitive cGMP 3',5'cyclic phosphodiesterase subunit delta
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV

# Metabolic_Enzyme_99_Number_of_Residues:
150

# Metabolic_Enzyme_99_Molecular_Weight:
17420

# Metabolic_Enzyme_99_Theoretical_pI:
5.35

# Metabolic_Enzyme_99_GO_Classification:
Not Available

# Metabolic_Enzyme_99_General_Function:
Not Available

# Metabolic_Enzyme_99_Specific_Function:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

# Metabolic_Enzyme_99_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_99_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_99_Pfam_Domain_Function:
PF05351:GMP_PDE_delta

# Metabolic_Enzyme_99_Signals:
None

# Metabolic_Enzyme_99_Transmembrane_Regions:
None

# Metabolic_Enzyme_99_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_99_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_99_GenBank_ID_Protein:
2896020

# Metabolic_Enzyme_99_SwissProt_ID:
PDE6D_HUMAN (O43924)

# Metabolic_Enzyme_99_swissprot_Name:
Not Available

# Metabolic_Enzyme_99_Genecard_id:
PDE6D

# Metabolic_Enzyme_99_Geneatlas_id:
PDE6D

# Metabolic_Enzyme_99_hgnc_id:
HGNC:8788

# Metabolic_Enzyme_99_PDB_ID:
1KSG

# Metabolic_Enzyme_99_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_99_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_99_Subcellular_Location:
Not Available

# Metabolic_Enzyme_99_Gene_Sequence:
>453 bp
ATGTCAGCCAAGGACGAGCGGGCCAGGGAGATCCTGAGGGGCTTCAAACTAAATTGGATG
AACCTTCGGGATGCTGAGACAGGGAAGATACTCTGGCAAGGAACAGAAGACCTGTCTGTC
CCTGGTGTGGAGCATGAAGCCCGTGTTCCCAAGAAAATCCTCAAGTGCAAGGCAGTGTCT
CGAGAACTTAATTTTTCTTCGACAGAACAAATGGAAAAATTCCGCCTGGAACAAAAAGTT
TACTTCAAAGGGCAATGCCTAGAAGAATGGTTCTTCGAGTTTGGCTTTGTGATCCCTAAC
TCCACAAATACCTGGCAGTCCTTGATAGAGGCAGCACCCGAGTCCCAGATGATGCCAGCA
AGCGTCTTAACTGGGAACGTTATCATAGAAACAAAGTTTTTTGACGACGATCTTCTTGTA
AGCACATCCAGAGTGAGACTTTTCTATGTTTGA

# Metabolic_Enzyme_99_GenBank_ID_Gene:
AF045999

# Metabolic_Enzyme_99_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_99_Locus:
2q35-q36

# Metabolic_Enzyme_99_SNPs:
rs8165; rs838447; rs1464974; rs838424; rs2570991; rs838448; rs6719408; rs7564574; rs838421; rs838446; rs6437035; rs6437036; rs4479418; rs1464976; rs865706; rs6727769; rs2340510; rs17271824; rs7564057; rs2693781; rs11682986; rs1055300; rs3912020; rs11691808; rs11886088; rs3748922; rs7578649; rs838459; rs1246073; rs838460; rs17271838; rs1986882; rs4973479; rs6729974; rs1246074; rs838442; rs838443; rs838423; rs4134454; rs4017857; rs838450; rs10208197; rs838445; rs10175192; rs16828383; rs11680005; rs11886978; rs2693782; rs10192111; rs11694559; rs1097849; rs17199642; rs1246072; rs11673810; rs1965569; rs865123; rs12466215; rs13425658; rs11687347; rs1097850; rs1464975; rs1246075; rs10174681; rs13412329; rs16828376; rs16828400; rs6437034; rs3830625; rs12468852; rs28364600; rs13424754; rs838425; rs35244888; rs838418; rs1246076; rs13388804; rs35193628; rs34916848; rs13017826; rs35427226; rs2340509; rs838444; rs35025339; rs11457200; rs2570994; rs34130127; rs3074725; rs34460175; rs1246067; rs6712578; rs866305; rs13392795; rs35343404; rs34916207; rs13020381; rs35633303; rs838420; rs2693778; rs838451; rs13416010; rs35413921; rs7574492; rs10164942; rs838415; rs3038045; rs13385970; rs36126237; rs11685411; rs10933382; rs34007857; rs34039711; rs13405908; rs34036079; rs838414; rs3887889; rs6745121; rs36043938; rs36094785; rs13412333; rs13029089; rs11413975; rs12620711; rs838449; rs12996166; rs1246069; rs2570990; rs34957131; rs36062317; rs34051193; rs35115820; rs955400; rs838417; rs13415801; rs3074722; rs13005798; rs1246068; rs34278996; rs34172773; rs838452; rs33924844; rs838416; rs7606479; rs12613234; rs838422; rs9973802; rs10168868; rs13020414; rs36006197; rs35042825; rs35145561; rs34036232; rs13417992; rs11679847; rs34089848; rs838419; rs13392965; rs13392413; rs838426; rs3210343; rs28642731; rs7607294; rs3210342; rs34031981; rs11557625; rs11682745; rs11689891; rs13392019; rs1554731; rs16825960; rs16828434; rs17199663; rs17271845; rs3748921; rs6437033; rs6732581; rs7598298; rs838427; rs838428; rs838429; rs838432

# Metabolic_Enzyme_99_General_References:
9570951; 9533031; 9781033; 10518933; 11980706

# Metabolic_Enzyme_99_References:
Not Available

# Metabolic_Enzyme_100_ID:
5271

# Metabolic_Enzyme_100_Name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

# Metabolic_Enzyme_100_Synonyms:
Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acyl- CoA synthetase short-chain family member 1

# Metabolic_Enzyme_100_Gene_Name:
ACSS1

# Metabolic_Enzyme_100_Protein_Sequence:
>Acetylcoenzyme A synthetase 2like, mitochondrial precursor
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

# Metabolic_Enzyme_100_Number_of_Residues:
689

# Metabolic_Enzyme_100_Molecular_Weight:
74857

# Metabolic_Enzyme_100_Theoretical_pI:
7.11

# Metabolic_Enzyme_100_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  AMP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
Function:  acetate-CoA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_100_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_100_Specific_Function:
Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)

# Metabolic_Enzyme_100_Pathway:
map00010  Glycolysis / Gluconeogenesis;
 map00620  Pyruvate metabolism;
 map00640  Propanoate metabolism;
 map00720  Reductive carboxylate cycle (CO2 fixation)

# Metabolic_Enzyme_100_Reaction:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

# Metabolic_Enzyme_100_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_100_Signals:
1-22

# Metabolic_Enzyme_100_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_100_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_100_EC_Link:
EC 6.2.1.1

# Metabolic_Enzyme_100_GenBank_ID_Protein:
56203089

# Metabolic_Enzyme_100_SwissProt_ID:
ACS2L_HUMAN (Q9NUB1)

# Metabolic_Enzyme_100_swissprot_Name:
Not Available

# Metabolic_Enzyme_100_Genecard_id:
ACSS1

# Metabolic_Enzyme_100_Geneatlas_id:
ACSS1

# Metabolic_Enzyme_100_hgnc_id:
HGNC:16091

# Metabolic_Enzyme_100_PDB_ID:
Not Available

# Metabolic_Enzyme_100_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_100_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_100_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_100_Gene_Sequence:
>1439 bp
CCAAGTGCAAGGTGGTTATCACCTTCAACCAAGGACTCCGGGGTGGGCGCGTGGTGGAGC
TGAAGAAAATAGTGGATGAGGCTGTGAAGCACTGCCCCACCGTGCAGCATGTCCTGGTGG
CTCACAGGACAGACAACAAGGTCCACATGGGGGATCTGGACGTCCCGCTGGAGCAGGAAA
TGGCCAAGGAGGACCCTGTTTGCGCCCCAGAGAGCATGGGCAGTGAGGACATGCTCTTCA
TGCTGTACACCTCAGGGAGCACCGGAATGCCCAAGGGCATCGTCCATACCCAGGCAGGCT
ACCTGCTCTATGCCGCCCTGACTCACAAGCTTGTGTTTGACCACCAGCCAGGTGACATCT
TTGGCTGTGTGGCCGACATCGGTTGGATTACAGGACACAGCTACGTGGTGTATGGGCCTC
TCTGCAATGGTGCCACCAGCGTCCTTTTTGAGAGCACCCCAGTTTATCCCAATGCTGGTC
GGTACTGGGAGACAGTAGAGAGGTTGAAGATCAATCAGTTCTATGGCGCCCCAACGGCTG
TCCGGCTGTTGCTGAAATACGGTGATGCCTGGGTGAAGAAGTATGATCGCTCCTCCCTGC
GGACCCTGGGGTCAGTGGGAGAGCCCATCAACTGTGAGGCCTGGGAGTGGCTTCACAGGG
TGGTGGGGGACAGCAGGTGCACGCTGGTGGACACCTGGTGGCAGACAGAAACAGGTGGCA
TCTGCATCGCACCACGGCCCTCGGAAGAAGGGGCGGAAATCCTCCCTGCCATGGCGATGA
GGCCCTTCTTTGGCATCGTCCCCGTCCTCATGGATGAGAAGGGCAGCGTCGTGGAGGGCA
GCAACGTCTCCGGGGCCCTGTGCATCTCCCAGGCCTGGCCGGGCATGGCCAGGACCATCT
ATGGCGACCACCAGCGATTTGTGGACGCCTACTTCAAGGCCTACCCAGGCTATTACTTCA
CTGGAGACGGGGCTTACCGAACTGAGGGCGGCTATTACCAGATCACAGGGCGGATGGATG
ATGTCATCAACATCAGTGGCCACCGGCTGGGGACCGCAGAGATTGAGGACGCCATCGCCG
ACCACCCTGCAGTACCAGAAAGTGCTGTCATTGGCTACCCCCACGACATCAAAGGAGAAG
CTGCCTTTGCCTTCATTGTGGTGAAAGATAGTGCGGGTGACTCAGATGTGGTGGTGCAGG
AGCTCAAGTCCATGGTGGCCACCAAGATCGCCAAATATGCTGTGCCTGATGAGATCCTGG
TGGTGAAACGTCTTCCAAAAACCAGGTCTGGGAAGGTCATGCGGCGGCTCCTGAGGAAGA
TCATCACTAGTGAGGCCCAGGAGCTGGGAGACACTACCACCTTGGAGGACCCCAGCATCA
TCGCAGAGATCCTGAGTGTCTACCAGAAGTGCAAGGACAAGCAGGCTGCTGCTAAGTGA

# Metabolic_Enzyme_100_GenBank_ID_Gene:
AL035661

# Metabolic_Enzyme_100_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_100_Locus:
20p11.23-p11.21

# Metabolic_Enzyme_100_SNPs:
rs6050249; rs6115003; rs6050259; rs6115001; rs3746331; rs6114999; rs6132784; rs6083718; rs2294980; rs3646; rs3746332; rs8118803; rs6050261; rs6050266; rs7270236; rs6132785; rs11697253; rs11699487; rs6050255; rs8114108; rs910526; rs1007881; rs6138466; rs6115000; rs6083728; rs11908104; rs3746330; rs6050281; rs6138473; rs6050267; rs8124799; rs6115002; rs6115010; rs910527; rs4815363; rs6132792; rs11908037; rs6083725; rs761720; rs6050252; rs7263112; rs6132789; rs6115015; rs2144371; rs2179732; rs4815364; rs6106989; rs8121327; rs4815361; rs6050268; rs11698964; rs6083726; rs6037010; rs7271250; rs6076312; rs1015278; rs6138478; rs1985485; rs6037007; rs6515575; rs11699824; rs11907003; rs6050263; rs6106986; rs12624595; rs6138475; rs6050262; rs6083729; rs6083727; rs7273310; rs6050270; rs11907817; rs6138470; rs8119255; rs12481389; rs7268879; rs6138474; rs7273518; rs6050257; rs6115011; rs6083730; rs4813543; rs4392331; rs6115009; rs6115008; rs7265897; rs13039383; rs1960190; rs11698942; rs6115013; rs6050264; rs11907559; rs7262168; rs7266133; rs6106985; rs6050253; rs12480685; rs6037013; rs1555157; rs1555158; rs7273872; rs6138465; rs6138464; rs7268196; rs6114995; rs3928737; rs6050244; rs7273998; rs6037006; rs6114996; rs6114997; rs6050290; rs1973921; rs9967918; rs6083719; rs41308619; rs6050250; rs41315096; rs34418920; rs7265950; rs6050247; rs8118553; rs6050245; rs6050246; rs6050248; rs11349463; rs6114998; rs3746333; rs11556305; rs6138480; rs6037009; rs2024740; rs6083720; rs6050282; rs34106051; rs34040475; rs6138467; rs7265967; rs35754748; rs6106987; rs7347286; rs7268641; rs35918514; rs5841047; rs6050285; rs11908357; rs6132786; rs10667081; rs6050273; rs6050288; rs35440489; rs11475510; rs11087496; rs6050283; rs2235848; rs6083721; rs41315094; rs5841046; rs35370044; rs6132788; rs6050258; rs35022349; rs6132787; rs36083645; rs6037011; rs34821066; rs6138479; rs33974103; rs34478164; rs6138481; rs6083731; rs6115018; rs7363000; rs6138472; rs6050286; rs35714586; rs6115014; rs6083723; rs6050265; rs8123929; rs35559944; rs34768826; rs6050275; rs35187537; rs6132793; rs34248454; rs4813544; rs6050269; rs6115012; rs33947143; rs6083724; rs34068044; rs34114131; rs34202442; rs6050272; rs35419604; rs11474894; rs34478614; rs7272596; rs34772607; rs11696684; rs6132791; rs3086647; rs6106990; rs6138471; rs11469635; rs7265721; rs10701711; rs11699715; rs6050271; rs35841792; rs6050251; rs8114568; rs34766073; rs34911154; rs6050284; rs34012555; rs35888097; rs6132790; rs11472149; rs8123923; rs34740612; rs36081306; rs7270177; rs8182893; rs6037008; rs11473680; rs6050287; rs11480696; rs6138476; rs6050274; rs34340531; rs4815365; rs8184324; rs33955639; rs5841045; rs11482316; rs6050289; rs35994199; rs7271571; rs1005409; rs11905625; rs11905675; rs2207631; rs2387573; rs2387577; rs4239751; rs6050243; rs6050291; rs6083712; rs6083713; rs6083714; rs6114987; rs6114991; rs6138461; rs6138462; rs7274899

# Metabolic_Enzyme_100_General_References:
11780052; 11347906; 12168954

# Metabolic_Enzyme_100_References:
Not Available

# Metabolic_Enzyme_101_ID:
5914

# Metabolic_Enzyme_101_Name:
Probable histidyl-tRNA synthetase, mitochondrial precursor

# Metabolic_Enzyme_101_Synonyms:
Histidine--tRNA ligase; HisRS; Histidine--tRNA ligase-like

# Metabolic_Enzyme_101_Gene_Name:
HARSL

# Metabolic_Enzyme_101_Protein_Sequence:
>Probable histidyltRNA synthetase, mitochondrial precursor
MPLLGLLPRRAWASLLSQLLRPPCASCTGAVRCQSQVAEAVLTSQLKAHQEKPNFIIKTP
KGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKD
QGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFDIA
GQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSID
KLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGL
GDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAA
GGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKN
FLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIR
SVASREEVAIKRENFVAEIQKRLSES

# Metabolic_Enzyme_101_Number_of_Residues:
506

# Metabolic_Enzyme_101_Molecular_Weight:
56889

# Metabolic_Enzyme_101_Theoretical_pI:
8.35

# Metabolic_Enzyme_101_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_101_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_101_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_101_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_101_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_101_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_101_Signals:
1-13

# Metabolic_Enzyme_101_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_101_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_101_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_101_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_101_SwissProt_ID:
SYHM_HUMAN (P49590)

# Metabolic_Enzyme_101_swissprot_Name:
Not Available

# Metabolic_Enzyme_101_Genecard_id:
HARSL

# Metabolic_Enzyme_101_Geneatlas_id:
HARSL

# Metabolic_Enzyme_101_hgnc_id:
HGNC:4817

# Metabolic_Enzyme_101_PDB_ID:
Not Available

# Metabolic_Enzyme_101_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_101_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_101_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_101_Gene_Sequence:
Not Available

# Metabolic_Enzyme_101_GenBank_ID_Gene:
U18936

# Metabolic_Enzyme_101_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_101_Locus:
5q31.3

# Metabolic_Enzyme_101_SNPs:
Not Available

# Metabolic_Enzyme_101_General_References:
7755634

# Metabolic_Enzyme_101_References:
Not Available

# Metabolic_Enzyme_102_ID:
5399

# Metabolic_Enzyme_102_Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor

# Metabolic_Enzyme_102_Synonyms:
E-NPP 2; Extracellular lysophospholipase D; LysoPLD; Autotaxin

# Metabolic_Enzyme_102_Gene_Name:
ENPP2

# Metabolic_Enzyme_102_Protein_Sequence:
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI

# Metabolic_Enzyme_102_Number_of_Residues:
863

# Metabolic_Enzyme_102_Molecular_Weight:
99004

# Metabolic_Enzyme_102_Theoretical_pI:
7.39

# Metabolic_Enzyme_102_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  nuclease activity
Function:  endonuclease activity
Function:  binding
Function:  nucleic acid binding
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_102_General_Function:
Not Available

# Metabolic_Enzyme_102_Specific_Function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development Tumor cell motility-stimulating factor

# Metabolic_Enzyme_102_Pathway:
Not Available

# Metabolic_Enzyme_102_Reaction:
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

# Metabolic_Enzyme_102_Pfam_Domain_Function:
PF01223:Endonuclease_NS;
PF01663:Phosphodiest;
PF01033:Somatomedin_B

# Metabolic_Enzyme_102_Signals:
1-27

# Metabolic_Enzyme_102_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_102_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_102_EC_Link:
EC 3.1.4.39

# Metabolic_Enzyme_102_GenBank_ID_Protein:
537906

# Metabolic_Enzyme_102_SwissProt_ID:
ENPP2_HUMAN (Q13822)

# Metabolic_Enzyme_102_swissprot_Name:
Not Available

# Metabolic_Enzyme_102_Genecard_id:
ENPP2

# Metabolic_Enzyme_102_Geneatlas_id:
ENPP2

# Metabolic_Enzyme_102_hgnc_id:
HGNC:3357

# Metabolic_Enzyme_102_PDB_ID:
Not Available

# Metabolic_Enzyme_102_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_102_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_102_Subcellular_Location:
Secreted protein. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells

# Metabolic_Enzyme_102_Gene_Sequence:
>2748 bp
ATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATATCCCTGTTCACTTTTGCCGTT
GGAGTCAGTATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAG
GAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAG
GGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGT
AAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGC
TGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGC
TCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGA
GAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGG
TTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAG
AAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCC
TACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGG
CTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCC
ACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTA
TGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATC
CCTCACGAGCGGAGAATATTAACCATATTGCGGTGGCTCACCCTGCCAGATCATGAGAGG
CCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCT
TTCGGCCCTGAGGAGAGTAGTTATGGCTCACCTTTTACTCCGGCTAAGAGACCTAAGAGG
AAAGTTGCCCCTAAGAGGAGACAGGAAAGACCAGTTGCTCCTCCAAAGAAAAGAAGAAGA
AAAATACATAGGATGGATCATTATGCTGCGGAAACTCGTCAGGACAAAATGACAAATCCT
CTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTG
CGTCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGAT
AGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGA
ACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATT
ATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCAC
CTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTG
GAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAA
TGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTT
GTAGGTTATGGCCCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAA
CTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCAT
GGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTT
ACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACT
TGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACA
AAAGGGTCTACAGAAGAGAGACACCTCCTCTATGGGCGACCTGCAGTGCTTTATCGGACT
AGATATGATATCTTATATCACACTGACTTTGAAAGTGGTTATAGTGAAATATTCCTAATG
CTACTCTGGACATCATATACTGTTTCCAAACAGGCTGAGGTTTCCAGCGTTCCTGACCAT
CTGACCAGTTGCGTCCGGCCTGATGTCCGTGTTTCTCCGAGTTTCAGTCAGAACTGTTTG
GCCTACAAAAATGATAAGCAGATGTCCTACGGATTCCTCTTTCCTCCTTATCTGAGCTCT
TCACCAGAGGCTAAATATGATGCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCT
TTCAAACGGGTCTGGAATTATTTCCAAAGGGTATTGGTGAAGAAATATGCTTCGGAAAGA
AATGGAGTTAACGTGATAAGTGGACCAATCTTCGACTATGACTATGATGGCTTACATGAC
ACAGAAGACAAAATAAAACAGTACGTGGAAGGCAGTTCCATTCCTGTTCCAACTCACTAC
TACAGCATCATCACCAGCTGTCTGGATTTCACTCAGCCTGCCGACAAGTGTGACGGCCCT
CTCTCTGTGTCCTCCTTCATCCTGCCTCACCGGCCTGACAACGAGGAGAGCTGCAATAGC
TCAGAGGACGAATCAAAATGGGTAGAAGAACTCATGAAGATGCACACAGCTAGGGTGCGT
GACATTGAACATCTCACCAGCCTGGACTTCTTCCGAAAGACCAGCCGCAGCTACCCAGAA
ATCCTGACACTCAAGACATACCTGCATACATATGAGAGCGAGATTTAA

# Metabolic_Enzyme_102_GenBank_ID_Gene:
L35594

# Metabolic_Enzyme_102_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_102_Locus:
8q24.1

# Metabolic_Enzyme_102_SNPs:
rs2289886; rs16892767; rs10283100; rs2305129; rs1058913; rs4871364; rs11985985; rs1374099; rs965670; rs745383; rs1374101; rs976423; rs2289889; rs2289888; rs2289885; rs2249015; rs755175; rs2305126; rs6986760; rs6469834; rs7012314; rs6469836; rs3793375; rs2305127; rs714607; rs7464710; rs7017581; rs11778951; rs7822457; rs10808504; rs10097147; rs11782782; rs7007302; rs7002854; rs6469833; rs6989212; rs6987232; rs4304355; rs7842699; rs4871360; rs6982484; rs4871420; rs6982863; rs4520196; rs2875905; rs2305125; rs989569; rs11786983; rs6469835; rs2289887; rs6987751; rs3793378; rs6986021; rs4404943; rs6987103; rs16892849; rs7001006; rs11784229; rs2305128; rs7842627; rs16892786; rs10505369; rs9297599; rs4871419; rs16892742; rs13277188; rs7813069; rs1374100; rs16892826; rs2243749; rs16892741; rs10505367; rs7008865; rs16892902; rs2326304; rs16892872; rs10098410; rs17194431; rs4871401; rs7007970; rs3793376; rs11775668; rs16892820; rs10505366; rs6988706; rs17803228; rs12676315; rs11775064; rs16892900; rs16892852; rs16892887; rs10112316; rs3816330; rs11776051; rs7823511; rs7341607; rs10505368; rs16892827; rs12678907; rs7832704; rs16892751; rs921044; rs17801314; rs1992721; rs16892771; rs2875906; rs12545361; rs16892790; rs2326306; rs16892846; rs10110878; rs16892773; rs16892758; rs16892862; rs16892856; rs11991811; rs3765048; rs10097368; rs7014683; rs7012371; rs7824058; rs965669; rs16892746; rs12544233; rs16892855; rs4870862; rs16892839; rs7837894; rs16892869; rs16892860; rs9297600; rs16892858; rs7012253; rs13249947; rs17192692; rs16892861; rs2326303; rs10097501; rs16892873; rs16892761; rs16892739; rs935360; rs16892821; rs16892807; rs6996637; rs17195493; rs6996969; rs16892857; rs11783720; rs3793377; rs2875904; rs16892899; rs16892776; rs930605; rs16892789; rs16892753; rs16892841; rs16892745; rs935359; rs7823839; rs4871352; rs10505370; rs1803184; rs1058906; rs16892735; rs11553603; rs12114595; rs34702922; rs33924986; rs11453074; rs28668309; rs34146810; rs7007883; rs11385263; rs34550309; rs3086095; rs10651155; rs13252721; rs35384858; rs13276243; rs36111215; rs34238300; rs35324801; rs35114182; rs35211061; rs28545338; rs11330516; rs35914708; rs10651072; rs35785012; rs34251243; rs13276659; rs12114608; rs2164020; rs36112518; rs13263113; rs33994893; rs35227070; rs3838711; rs33956494; rs36108971; rs2326305; rs5894487; rs34087519; rs34647615; rs33962227; rs1865292; rs35332847; rs36157726; rs35136821; rs5894486; rs34846612; rs11385264; rs35287985; rs35074738; rs11453075; rs34149540; rs35057967; rs5894490; rs6988878; rs34069990; rs11779231; rs11314064; rs12678024; rs16892865; rs3765047; rs13252311; rs12114603; rs12680671; rs35328333; rs34249912; rs28719904; rs11994348; rs13252720; rs12386860; rs34044773; rs36023475; rs34746070; rs4871386; rs10602946; rs5894485; rs28424130; rs5024451; rs28627521; rs34894575; rs34497035; rs13265442; rs12114895; rs35853660; rs36108877; rs11424718; rs35516242; rs11784273; rs33940123; rs35601421; rs35132277; rs12114601; rs3217556; rs5894491; rs34469483; rs13266547; rs28401282; rs34795457; rs34309572; rs11474049; rs35694268; rs28430495; rs35109858; rs35459102; rs3835102; rs28528985; rs34900958; rs28687495; rs10110618; rs35805857; rs35384459; rs34294314; rs34078353; rs10660917; rs7829304; rs34745934; rs28500566; rs12114602; rs34896929; rs11300090; rs33942871; rs34042284; rs6986623; rs35656304; rs41408746; rs41524345; rs13281228; rs1529780; rs1529781; rs16892878; rs16892912; rs17215053; rs2028849; rs6469837; rs7008680; rs7839329; rs7840386; rs965301; rs994392

# Metabolic_Enzyme_102_General_References:
7982964; 8579579; 8586446

# Metabolic_Enzyme_102_References:
Not Available

# Metabolic_Enzyme_103_ID:
5915

# Metabolic_Enzyme_103_Name:
Ubiquitin-conjugating enzyme E2 J1

# Metabolic_Enzyme_103_Synonyms:
Non-canonical ubiquitin-conjugating enzyme 1; NCUBE1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E; HSUBC6e

# Metabolic_Enzyme_103_Gene_Name:
UBE2J1

# Metabolic_Enzyme_103_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 J1
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHG
RIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMP
TKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELA
RQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQP
TQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHTDHGGSAVLIVILTLALAA
LIFRRIYLANEYIFDFEL

# Metabolic_Enzyme_103_Number_of_Residues:
318

# Metabolic_Enzyme_103_Molecular_Weight:
35199

# Metabolic_Enzyme_103_Theoretical_pI:
6.74

# Metabolic_Enzyme_103_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_103_General_Function:
Not Available

# Metabolic_Enzyme_103_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum

# Metabolic_Enzyme_103_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_103_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_103_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_103_Signals:
None

# Metabolic_Enzyme_103_Transmembrane_Regions:
283-303

# Metabolic_Enzyme_103_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_103_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_103_GenBank_ID_Protein:
7362973

# Metabolic_Enzyme_103_SwissProt_ID:
UB2J1_HUMAN (Q9Y385)

# Metabolic_Enzyme_103_swissprot_Name:
Not Available

# Metabolic_Enzyme_103_Genecard_id:
UBE2J1

# Metabolic_Enzyme_103_Geneatlas_id:
UBE2J1

# Metabolic_Enzyme_103_hgnc_id:
HGNC:17598

# Metabolic_Enzyme_103_PDB_ID:
Not Available

# Metabolic_Enzyme_103_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_103_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_103_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass type IV membrane protein

# Metabolic_Enzyme_103_Gene_Sequence:
>957 bp
ATGGAGACCCGCTACAACCTGAAGAGTCCGGCTGTTAAACGTTTAATGAAAGAAGCGGCA
GAATTGAAAGATCCAACAGATCATTACCATGCGCAGCCTTTAGAGGATAACCTTTTTGAA
TGGCACTTCACGGTTAGAGGGCCCCCAGACTCCGATTTTGATGGAGGAGTTTATCACGGG
CGGATAGTACTGCCACCAGAGTATCCCATGAAACCACCAAGCATTATTCTCCTAACGGCT
AATGGTCGATTTGAAGTGGGCAAGAAAATCTGTTTGAGCATCTCAGGCCATCATCCTGAA
ACTTGGCAGCCTTCGTGGAGTATAAGGACAGCATTATTAGCCATCATTGGGTTTATGCCA
ACAAAAGGAGAGGGAGCCATAGGTTCTCTAGATTACACTCCTGAGGAAAGAAGAGCACTT
GCCAAAAAATCACAAGATTTCTGTTGTGAAGGATGTGGCTCTGCCATGAAGGATGTCCTG
TTGCCTTTAAAATCTGGAAGCGATTCAAGCCAAGCTGACCAAGAAGCCAAAGAACTGGCT
AGGCAAATAAGCTTTAAGGCAGAAGTCAATTCATCTGGAAAGACTATCTCTGAGTCAGAC
TTAAACCACTCTTTTTCACTAACTGATTTACAAGATGATATACCTACAACATTCCAGGGT
GCTACGGCCAGTACATCGTACGGACTCCAGAATTCCTCAGCAGCATCCTTTCATCAACCT
ACCCAACCTGTAGCTAAGAATACCTCCATGAGCCCTCGACAGCGCCGGGCCCAGCAGCAG
AGTCAGAGAAGGTTGTCTACTTCACCAGATGTAATCCAGGGCCACCAGCCAAGAGACAAC
CACACTGATCATGGTGGGTCAGCTGTACTGATTGTCATCCTGACTTTGGCATTGGCAGCT
CTTATATTCCGACGAATATATCTGGCAAACGAATACATATTTGACTTTGAGTTATAA

# Metabolic_Enzyme_103_GenBank_ID_Gene:
AJ245898

# Metabolic_Enzyme_103_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_103_Locus:
6q15

# Metabolic_Enzyme_103_SNPs:
Not Available

# Metabolic_Enzyme_103_General_References:
10708578; 12082160; 10810093; 11042152; 14574404

# Metabolic_Enzyme_103_References:
Not Available

# Metabolic_Enzyme_104_ID:
5916

# Metabolic_Enzyme_104_Name:
Long-chain-fatty-acid--CoA ligase 5

# Metabolic_Enzyme_104_Synonyms:
Long-chain acyl-CoA synthetase 5; LACS 5

# Metabolic_Enzyme_104_Gene_Name:
ACSL5

# Metabolic_Enzyme_104_Protein_Sequence:
>LongchainfattyacidCoA ligase 5
MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVS
QKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGS
CLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADI
AMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLG
KEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDV
AISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYD
KVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGA
APMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVA
DMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDR
KKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKL
GVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLK
AKRGELSKYFRTQIDSLYEHIQD

# Metabolic_Enzyme_104_Number_of_Residues:
683

# Metabolic_Enzyme_104_Molecular_Weight:
75992

# Metabolic_Enzyme_104_Theoretical_pI:
6.91

# Metabolic_Enzyme_104_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_104_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_104_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids

# Metabolic_Enzyme_104_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_104_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_104_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_104_Signals:
1-35

# Metabolic_Enzyme_104_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_104_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_104_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_104_GenBank_ID_Protein:
6174680

# Metabolic_Enzyme_104_SwissProt_ID:
ACSL5_HUMAN (Q9ULC5)

# Metabolic_Enzyme_104_swissprot_Name:
Not Available

# Metabolic_Enzyme_104_Genecard_id:
ACSL5

# Metabolic_Enzyme_104_Geneatlas_id:
ACSL5

# Metabolic_Enzyme_104_hgnc_id:
HGNC:16526

# Metabolic_Enzyme_104_PDB_ID:
Not Available

# Metabolic_Enzyme_104_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_104_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_104_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_104_Gene_Sequence:
>2052 bp
ATGCTTTTTATCTTTAACTTTTTGTTTTCCCCACTTCCGACCCCGGCGTTGATCTGCATC
CTGACATTTGGAGCTGCCATCTTCTTGTGGCTGATCACCAGACCTCAACCCGTCTTACCT
CTTCTTGACCTGAACAATCAGTCTGTGGGAATTGAGGGAGGAGCACGGAAGGGGGTTTCC
CAGAAGAACAATGACCTAACAAGTTGCTGCTTCTCAGATGCCAAGACTATGTATGAGGTT
TTCCAAAGAGGACTCGCTGTGTCTGACAATGGGCCCTGCTTGGGATATAGAAAACCAAAC
CAGCCCTACAGATGGCTATCTTACAAACAGGTGTCTGATAGAGCAGAGTACCTGGGTTCC
TGTCTCTTGCATAAAGGTTATAAATCATCACCAGACCAGTTTGTCGGCATCTTTGCTCAG
AATAGGCCAGAGTGGATCATCTCCGAATTGGCTTGTTACACGTACTCTATGGTAGCTGTA
CCTCTGTATGACACCTTGGGACCAGAAGCCATCGTACATATTGTCAACAAGGCTGATATC
GCCATGGTGATCTGTGACACACCCCAAAAGGCATTGGTGCTGATAGGGAATGTAGAGAAA
GGCTTCACCCCGAGCCTGAAGGTGATCATCCTTATGGACCCCTTTGATGATGACCTGAAG
CAAAGAGGGGAGAAGAGTGGAATTGAGATCTTATCCCTATATGATGCTGAGAACCTAGGC
AAAGAGCACTTCAGAAAACCTGTGCCTCCTAGCCCAGAAGACCTGAGCGTCATCTGCTTC
ACCAGTGGGACCACAGGTGACCCCAAAGGAGCCATGATAACCCATCAAAATATTGTTTCA
AATGCTGCTGCCTTTCTCAAATGTGTGGAGCATGCTTATGAGCCCACTCCTGATGATGTG
GCCATATCCTACCTCCCTCTGGCTCATATGTTTGAGAGGATTGTACAGGCTGTTGTGTAC
AGCTGTGGAGCCAGAGTTGGATTCTTCCAAGGGGATATTCGGTTGCTGGCTGACGACATG
AAGACTTTGAAGCCCACATTGTTTCCCGCGGTGCCTCGACTCCTTAACAGGATCTACGAT
AAGGTACAAAATGAGGCCAAGACACCCTTGAAGAAGTTCTTGTTGAAGCTGGCTGTTTCC
AGTAAATTCAAAGAGCTTCAAAAGGGTATCATCAGGCATGATAGTTTCTGGGACAAGCTC
ATCTTTGCAAAGATCCAGGACAGCCTGGGCGGAAGGGTTCGTGTAATTGTCACTGGAGCT
GCCCCCATGTCCACTTCAGTCATGACATTCTTCCGGGCAGCAATGGGATGTCAGGTGTAT
GAAGCTTATGGTCAAACAGAATGCACAGGTGGCTGTACATTTACATTACCTGGGGACTGG
ACATCAGGTCACGTTGGGGTGCCCCTGGCTTGCAATTACGTGAAGCTGGAAGATGTGGCT
GACATGAACTACTTTACAGTGAATAATGAAGGAGAGGTCTGCATCAAGGGTACAAACGTG
TTCAAAGGATACCTGAAGGACCCTGAGAAGACACAGGAAGCCCTGGACAGTGATGGCTGG
CTTCACACAGGAGACATTGGTCGCTGGCTCCCGAATGGAACTCTGAAGATCATCGACCGT
AAAAAGAACATTTTCAAGCTGGCCCAAGGAGAATACATTGCACCAGAGAAGATAGAAAAT
ATCTACAACAGGAGTCAACCAGTGTTACAAATTTTTGTACACGGGGAGAGCTTACGGTCA
TCCTTAGTAGGAGTGGTGGTTCCTGACACAGATGTACTTCCCTCATTTGCAGCCAAGCTT
GGGGTGAAGGGCTCCTTTGAGGAACTGTGCCAAAACCAAGTTGTAAGGGAAGCCATTTTA
GAAGACTTGCAGAAAATTGGGAAAGAAAGTGGCCTTAAAACTTTTGAACAGGTCAAAGCC
ATTTTTCTTCATCCAGAGCCATTTTCCATTGAAAATGGGCTCTTGACACCAACATTGAAA
GCAAAGCGAGGAGAGCTTTCCAAATACTTTCGGACCCAAATTGACAGCCTGTATGAGCAC
ATCCAGGATTAG

# Metabolic_Enzyme_104_GenBank_ID_Gene:
AB033899

# Metabolic_Enzyme_104_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_104_Locus:
10q25.1-q25.2

# Metabolic_Enzyme_104_SNPs:
rs3736946; rs12254915; rs11812261; rs11195943; rs1926564; rs11195936; rs2277208; rs8624; rs943260; rs11195938; rs7077197; rs7904386; rs10749118; rs3808920; rs4918747; rs10885342; rs9787487; rs7075592; rs7077060; rs4918744; rs12255316; rs2419621; rs11195940; rs17129748; rs11593532; rs17674469; rs11591311; rs11195942; rs4918745; rs7906445; rs11813362; rs10466200; rs4341465; rs11195939; rs3184349; rs12414442; rs7906780; rs7076991; rs4918748; rs11195949; rs876873; rs2900945; rs2419629; rs4333963; rs10885343; rs7904918; rs10787446; rs3736947; rs4501923; rs4351741; rs10885345; rs17129769; rs7919710; rs17129754; rs2419630; rs7904008; rs2419628; rs2256368; rs3740142; rs7068528; rs11598016; rs2255740; rs10885346; rs11195948; rs3780955; rs11195951; rs4918749; rs10787447; rs2419627; rs10885344; rs17129773; rs11195945; rs4439448; rs7477424; rs3981453; rs10885347; rs2419626; rs12779472; rs11195947; rs12258615; rs11195952; rs10509962; rs2419620; rs2256624; rs34719950; rs35183065; rs34585626; rs17129766; rs11195941; rs35907887; rs11484417; rs2148492; rs34575343; rs11195937; rs35808367; rs11368853; rs35383388; rs35865752; rs41292614; rs34055026; rs7097655; rs12773987; rs2234892; rs35583048; rs34096364; rs11312208; rs12218402; rs11556760; rs6144093; rs36000541; rs11195956; rs35482413; rs35032191; rs36047610; rs1887138; rs34852976; rs33994899; rs36038734; rs5787960; rs7097926; rs12242416; rs36108519; rs11389157; rs7093104; rs35097669; rs34088280; rs10614072; rs11286757; rs3840746; rs12778602; rs10736220; rs41292612; rs12768618; rs11385028; rs11195953; rs4572070; rs2290961; rs11420647; rs35238427; rs11195954; rs12769975; rs41292616; rs28559631; rs35942715; rs12769807; rs36089354; rs11195955; rs34258799; rs12768527; rs11195944; rs35708833; rs35777700; rs41306862; rs12768201; rs12768606; rs34850601; rs12221085; rs35770074; rs35514063; rs34659621; rs11195946; rs12769983; rs2616604; rs34678944; rs7899118; rs10635238; rs12266904; rs35166547; rs11385029; rs3831106; rs12769568; rs34341101; rs7097632; rs12570828; rs12249109; rs34684189; rs34799035; rs34129748; rs35529824; rs35568832; rs12769961; rs3830190; rs34709620; rs36004790; rs4918750; rs7477548; rs12769564; rs34464188; rs2251650; rs2234969; rs12249181; rs11311243; rs11311716; rs34021735; rs11382874; rs10509961; rs11598819; rs12098576; rs12268778; rs12356966; rs12414780; rs2094266; rs2290965; rs2306158; rs2419619; rs2419622; rs2900946; rs3180431; rs34823410; rs3736058; rs3736059; rs4314988; rs4550159; rs4917634; rs4917635; rs4918751; rs7070744; rs7100970; rs723373

# Metabolic_Enzyme_104_General_References:
12975309

# Metabolic_Enzyme_104_References:
Not Available

# Metabolic_Enzyme_105_ID:
5917

# Metabolic_Enzyme_105_Name:
Histidyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_105_Synonyms:
Histidine--tRNA ligase; HisRS

# Metabolic_Enzyme_105_Gene_Name:
HARS

# Metabolic_Enzyme_105_Protein_Sequence:
>HistidyltRNA synthetase, cytoplasmic
MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK
GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL
LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS
VTSREEVDVRREDLVEEIKRRTGQPLCIC

# Metabolic_Enzyme_105_Number_of_Residues:
509

# Metabolic_Enzyme_105_Molecular_Weight:
57411

# Metabolic_Enzyme_105_Theoretical_pI:
5.56

# Metabolic_Enzyme_105_GO_Classification:
>>>
Function:  histidine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  histidyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_105_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_105_Specific_Function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_105_Pathway:
map00340  Histidine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_105_Reaction:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

# Metabolic_Enzyme_105_Pfam_Domain_Function:
PF03129:HGTP_anticodon;
PF00587:tRNA-synt_2b;
PF00458:WHEP-TRS

# Metabolic_Enzyme_105_Signals:
None

# Metabolic_Enzyme_105_Transmembrane_Regions:
None

# Metabolic_Enzyme_105_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_105_EC_Link:
EC 6.1.1.21

# Metabolic_Enzyme_105_GenBank_ID_Protein:
32460

# Metabolic_Enzyme_105_SwissProt_ID:
SYHC_HUMAN (P12081)

# Metabolic_Enzyme_105_swissprot_Name:
Not Available

# Metabolic_Enzyme_105_Genecard_id:
HARS

# Metabolic_Enzyme_105_Geneatlas_id:
HARS

# Metabolic_Enzyme_105_hgnc_id:
HGNC:4816

# Metabolic_Enzyme_105_PDB_ID:
Not Available

# Metabolic_Enzyme_105_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_105_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_105_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_105_Gene_Sequence:
>1530 bp
ATGGCAGAGCGTGCGGCGCTGGAGGAGCTGGTGAAACTTCAGGGAGAGCGCGTGCGAGGC
CTCAAGCAGCAGAAGGCCAGCGCCGAGCTGATCGAGGAGGAGGTGGCGAAACTCCTGAAA
CTGAAGGCACAGCTGGGTCCTGATGAAAGCAAACAGAAATTTGTGCTCAAAACCCCCAAG
GGCACAAGAGACTATAGTCCCCGGCAGATGGCAGTTCGCGAGAAGGTGTTTGACGTAATC
ATCCGTTGCTTCAAGCGCCACGGTGCAGAAGTCATTGATACACCTGTATTTGAACTAAAG
GAAACACTGATGGGAAAGTATGGGGAAGACTCCAAGCTTATCTATGACCTGAAGGACCAG
GGCGGGGAGCTCCTGTCCCTTCGCTATGACCTCACTGTTCCTTTTGCTCGGTATTTGGCA
ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAGGTATATCGGCGGGATAAC
CCAGCCATGACCCGTGGCCGATACCGGGAATTCTACCAGTGTGATTTTGACATTGCTGGG
AACTTTGATCCCATGATCCCTGATGCAGAGTGCCTGAAGATCATGTGCGAGATCCTGAGT
TCACTTCAGATAGGCGACTTCCTGGTCAAGGTAAACGATCGACGCATTCTAGATGGGATG
TTTGCTATCTGTGGTGTTTCTGACAGCAAGTTCCGTACCATCTGCTCCTCAGTAGACAAG
CTGGACAAGGTGTCCTGGGAAGAGGTGAAGAATGAGATGGTGGGAGAGAAGGGCCTTGCA
CCTGAGGTGGCTGACCGCATTGGGGACTATGTCCAGCAACATGGTGGGGTATCCCTGGTG
GAACAGCTGCTCCAGGATCCTAAACTATCCCAAAACAAGCAGGCCTTGGAGGGCCTGGGA
GACCTGAAGTTGCTCTTTGAGTACCTGACCCTATTTGGCATTGATGACAAAATCTCCTTT
GACCTGAGCCTTGCTCGAGGGCTGGATTACTACACTGGGGTGATCTATGAGGCAGTGCTG
CTACAGACCCCAGCCCAGGCAGGGGAAGAGCCCCTGGGTGTGGGCAGTGTGGCTGCTGGA
GGACGCTATGATGGGCTAGTGGGCATGTTCGACCCCAAAGGGCGCAAGGTGCCATGTGTG
GGGCTCAGCATTGGGGTGGAGCGGATTTTCTCCATCGTGGAACAGAGACTAGAGGCTTTG
GAGGAGAAGATACGGACCACGGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG
CTAGAGGAAAGACTAAAGCTTGTCTCAGAACTGTGGGATGCTGGGATCAAGGCTGAGCTG
CTGTACAAGAAGAACCCAAAGCTACTGAACCAGTTACAGTACTGTGAGGAGGCAGGCATC
CCACTGGTGGCTATCATCGGCGAGCAGGAACTCAAGGATGGGGTCATCAAGCTCCGTTCA
GTGACGAGCAGGGAAGAGGTGGATGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG
AGAACAGGCCAGCCCCTCTGCATCTGCTGA

# Metabolic_Enzyme_105_GenBank_ID_Gene:
Z11518

# Metabolic_Enzyme_105_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_105_Locus:
5q31.3

# Metabolic_Enzyme_105_SNPs:
rs2230361; rs2073512; rs702396; rs11954514; rs811382; rs801185; rs801189; rs2530239; rs801186; rs1089305; rs812381; rs801187; rs6880190; rs11745372; rs1131045; rs1131041; rs1050250; rs1131042; rs1050246; rs1131040; rs1131035; rs1131034; rs1131039; rs1131046; rs1131036; rs1050247; rs1050249; rs1050251; rs1050248; rs1131032; rs1131043; rs1131038; rs1050245; rs1131033; rs1131044; rs1050252; rs11548124; rs1131037; rs35217222; rs6873628; rs1089304; rs34246519; rs34291233; rs35790592; rs2530240; rs10713463; rs10534451; rs4334930; rs7701545; rs5871749; rs801188; rs11344157; rs12653992; rs10534452; rs13180544; rs10300; rs1050222; rs10515510; rs1065342; rs12513490; rs12652092; rs13169368; rs17119056; rs2251860; rs2286394; rs2302104; rs2530234; rs2530241; rs2530242; rs2530243; rs2530245; rs2530246; rs2563302; rs2563304; rs2563305; rs2563312; rs2563314; rs2563335; rs3177856; rs3180057; rs34342435; rs34589480; rs34732372; rs34790864; rs35080423; rs35983033; rs3887397; rs6880619; rs6883035; rs7706544; rs7715879; rs801168

# Metabolic_Enzyme_105_General_References:
1549469; 3554142; 8406012; 7755634

# Metabolic_Enzyme_105_References:
Not Available

# Metabolic_Enzyme_106_ID:
5918

# Metabolic_Enzyme_106_Name:
Seryl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_106_Synonyms:
Seryl-tRNA(Ser/Secsynthetase; Serine--tRNA ligase; SerRS

# Metabolic_Enzyme_106_Gene_Name:
SARS

# Metabolic_Enzyme_106_Protein_Sequence:
>SeryltRNA synthetase, cytoplasmic
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA

# Metabolic_Enzyme_106_Number_of_Residues:
514

# Metabolic_Enzyme_106_Molecular_Weight:
58778

# Metabolic_Enzyme_106_Theoretical_pI:
6.38

# Metabolic_Enzyme_106_GO_Classification:
>>>
Function:  serine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  seryl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_106_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_106_Specific_Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

# Metabolic_Enzyme_106_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_106_Reaction:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)

# Metabolic_Enzyme_106_Pfam_Domain_Function:
PF02403:Seryl_tRNA_N;
PF00587:tRNA-synt_2b

# Metabolic_Enzyme_106_Signals:
None

# Metabolic_Enzyme_106_Transmembrane_Regions:
None

# Metabolic_Enzyme_106_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_106_EC_Link:
EC 6.1.1.11

# Metabolic_Enzyme_106_GenBank_ID_Protein:
1050527

# Metabolic_Enzyme_106_SwissProt_ID:
SYSC_HUMAN (P49591)

# Metabolic_Enzyme_106_swissprot_Name:
Not Available

# Metabolic_Enzyme_106_Genecard_id:
SARS

# Metabolic_Enzyme_106_Geneatlas_id:
SARS

# Metabolic_Enzyme_106_hgnc_id:
HGNC:10537

# Metabolic_Enzyme_106_PDB_ID:
Not Available

# Metabolic_Enzyme_106_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_106_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_106_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_106_Gene_Sequence:
>1545 bp
ATGGTGCTGGATCTGGATTTGTTTCGGGTGGATAAAGGAGGGGACCCAGCCCTCATCCGA
GAGACGCAGGAGAAGCGCTTCAAGGACCCGGGACTAGTGGACCAGCTGGTGAAGGCAGAC
AGCGAGTGGCGACGATGTAGATTTCGGGCAGACAACTTGAGCAAGCTGAAGAACCTATGC
AGCAAGACAATCGGAGAGAAAATGAAGAAAAAAGAGCCAGTGGGAGATGATGAGTCTGTC
CCAGAGAATGTGCTGAGTTTCGATGACCTTACTGCAGACGCTTTAGCTAACCTGAAAGTC
TCACAAATCAAAAAAGTCCGACTCCTCATTGATGAAGCCATCCTGAAGTGTGACGCGGAG
CGGATAAAGTTGGAAGCAGAGCGGTTTGAGAACCTCCGAGAGATTGGGAACCTTCTGCAC
CCTTCTGTACCCATCAGTAACGATGAGGATGTGGACAACAAAGTAGAGAGGATTTGGGGC
GATTGTACAGTCAGGAAGAAGTACTCTCATGTGGACCTGGTGGTGATGGTAGATGGCTTT
GAAGGCGAAAAGGGGGCCGTGGTGGCTGGGAGTCGAGGGTACTTCTTGAAGGGGGTCCTG
GTGTTCCTGGAACAGGCTCTCATCCAGTATGCCCTTCGCACCTTGGGAAGTCGGGGCTAC
ATTCCCATTTATACCCCCTTTTTCATGAGGAAGGAGGTCATGCAGGAGGTGGCACAGCTC
AGCCAGTTTGATGAAGAACTTTATAAGGTGATTGGCAAAGGCAGTGAAAAGTCTGATGAC
AACTCCTATGATGAGAAGTACCTGATTGCCACCTCAGAGCAGCCCATTGCTGCCCTGCAC
CGGGATGAGTGGCTCCGGCCGGAGGACCTGCCCATCAAGTATGCTGGCCTGTCTACCTGC
TTCCGTCAGGAGGTGGGCTCCCATGGCCGTGACACCCGTGGCATCTTCCGAGTCCATCAG
TTTGAGAAGATTGAACAGTTTGTGTACTCATCACCCCATGACAACAAGTCATGGGAGATG
TTTGAAGAGATGATTACCACCGCAGAGGAGTTCTACCAGTCCCTGGGGATTCCTTACCAC
ATTGTGAATATTGTCTCAGGTTCTTTGAATCATGCTGCCAGTAAGAAGCTTGACCTGGAG
GCCTGGTTTCCGGGCTCAGGAGCCTTCCGTGAGTTGGTCTCCTGTTCTAATTGCACGGAT
TACCAGGCTCGCCGGCTTCGAATCCGATATGGGCAAACCAAGAAGATGATGGACAAGGTG
GAGTTTGTCCATATGCTCAATGCTACCATGTGCGCCACTACCCGTACCATCTGCGCCATC
CTGGAGAACTACCAGACAGAGAAGGGCATCACTGTGCCTGAGAAATTGAAGGAGTTCATG
CCGCCAGGACTGCAAGAACTGATCCCCTTTGTGAAGCCTGCGCCCATTGAGCAGGAGCCA
TCAAAGAAGCAGAAGAAGCAACATGAGGGCAGCAAAAAGAAAGCAGCAGCAAGAGACGTC
ACCCTAGAAAACAGGCTGCAGAACATGGAGGTCACCGATGCTTGA

# Metabolic_Enzyme_106_GenBank_ID_Gene:
X91257

# Metabolic_Enzyme_106_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_106_Locus:
1p13.3-p13.1

# Metabolic_Enzyme_106_SNPs:
rs608511; rs683182; rs3120625; rs669697; rs600711; rs658092; rs685653; rs7539716; rs4970832; rs2924; rs687074; rs584116; rs12028612; rs2182598; rs682612; rs642581; rs626704; rs11102960; rs4970831; rs4268379; rs626784; rs1277927; rs7552768; rs11102962; rs4970830; rs3118502; rs7537308; rs7547246; rs654040; rs9661235; rs12127592; rs3118501; rs17643426; rs17856306; rs11547491; rs11547492; rs1277925; rs2358959; rs12067741; rs11380452; rs41279696; rs12403825; rs35069915; rs34158040; rs12354027; rs34115802; rs657511; rs7539230; rs35425522; rs11339198; rs12749308; rs1556768; rs1277928; rs12075220; rs35018700; rs11311821; rs34647086; rs639608; rs2281895; rs12125002; rs5776968; rs639246; rs2485323; rs7544116; rs1556769; rs631927; rs34756917; rs12129083; rs4970829; rs11102959; rs34528252; rs11439617; rs607087; rs35694777; rs2358960; rs34812410; rs12128523; rs34133284; rs12130045; rs3120626; rs3834101; rs34159080; rs11375361; rs12754293; rs35376223; rs11436487; rs3203683; rs41279698; rs11306493; rs10624420; rs654469; rs35271870; rs11804423; rs12081406; rs35625457; rs7552765; rs1277926; rs34764041; rs6703402; rs11102955; rs11102957; rs11102964; rs11102965; rs12067069; rs1277921; rs17034539; rs17034541; rs17034619; rs17035415; rs17035443; rs3088350; rs3197233; rs4246519; rs4246520; rs4623734; rs4970827; rs585362; rs586254; rs587805; rs602265; rs603643; rs604500; rs607067; rs611060; rs611905; rs611945; rs663741; rs6656935; rs688386

# Metabolic_Enzyme_106_General_References:
9431993

# Metabolic_Enzyme_106_References:
Not Available

# Metabolic_Enzyme_107_ID:
5919

# Metabolic_Enzyme_107_Name:
Long-chain-fatty-acid--CoA ligase 3

# Metabolic_Enzyme_107_Synonyms:
Long-chain acyl-CoA synthetase 3; LACS 3

# Metabolic_Enzyme_107_Gene_Name:
ACSL3

# Metabolic_Enzyme_107_Protein_Sequence:
>LongchainfattyacidCoA ligase 3
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPV
NSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPN
GKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACF
MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGK
PPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMIS
HSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQ
SSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQI
SKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTES
AGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYY
KNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAA
LKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLK
VLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK


# Metabolic_Enzyme_107_Number_of_Residues:
720

# Metabolic_Enzyme_107_Molecular_Weight:
80421

# Metabolic_Enzyme_107_Theoretical_pI:
8.51

# Metabolic_Enzyme_107_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_107_General_Function:
Lipid transport and metabolism 

# Metabolic_Enzyme_107_Specific_Function:
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates

# Metabolic_Enzyme_107_Pathway:
map00071  Fatty acid metabolism

# Metabolic_Enzyme_107_Reaction:
ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

# Metabolic_Enzyme_107_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_107_Signals:
1-31

# Metabolic_Enzyme_107_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_107_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_107_EC_Link:
EC 6.2.1.3

# Metabolic_Enzyme_107_GenBank_ID_Protein:
4165018

# Metabolic_Enzyme_107_SwissProt_ID:
ACSL3_HUMAN (O95573)

# Metabolic_Enzyme_107_swissprot_Name:
Not Available

# Metabolic_Enzyme_107_Genecard_id:
ACSL3

# Metabolic_Enzyme_107_Geneatlas_id:
ACSL3

# Metabolic_Enzyme_107_hgnc_id:
HGNC:3570

# Metabolic_Enzyme_107_PDB_ID:
Not Available

# Metabolic_Enzyme_107_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_107_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_107_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type III membrane protein. Peroxisome; peroxisomal membrane; single-pass type III membrane protein (By similarity). Microsome; microsomal membrane; single-pass type III membrane protein (By similarity)

# Metabolic_Enzyme_107_Gene_Sequence:
>2163 bp
ATGAATAACCACGTGTCTTCAAAACCATCTACCATGAAGCTAAAACATACCATCAACCCT
ATTCTTTTATATTTTATACATTTTCTAATATCACTTTATACTATTTTAACATACATTCCG
TTTTATTTTTTCTCCGAGTCAAGACAAGAAAAATCAAACCGAATTAAAGCAAAGCCTGTA
AATTCAAAACCTGATTCTGCATACAGATCTGTTAATAGTTTGGATGGTTTGGCTTCAGTA
TTATACCCTGGATGTGATACTTTAGATAAAGTTTTTACATATGCAAAAAACAAATTTAAG
AACAAAAGACTCTTGGGAACACGTGAAGTTTTAAATGAGGAAGATGAAGTACAACCAAAT
GGAAAAATTTTTAAAAAGGTTATTCTTGGACAGTATAATTGGCTTTCCTATGAAGATGTC
TTTGTTCGAGCCTTTAATTTTGGAAATGGATTACAGATGTTGGGTCAGAAACCAAAGACC
AACATCGCCATCTTCTGTGAGACCAGGGCCGAGTGGATGATAGCTGCACAGGCGTGTTTT
ATGTATAATTTTCAGCTTGTTACATTATATGCCACTCTAGGAGGTCCAGCCATTGTTCAT
GCATTAAATGAAACAGAGGTGACCAACATCATTACTAGTAAAGAACTCTTACAAACAAAG
TTGAAGGATATAGTTTCTTTGGTCCCACGCCTGCGGCACATCATCACTGTTGATGGAAAG
CCACCGACCTGGTCCGACTTCCCCAAGGGCATCATTGTGCATACCATGGCTGCAGTGGAG
GCCCTGGGAGCCAAGGCCAGCATGGAAAACCAACCTCATAGCAAACCATTGCCCTCAGAT
ATTGCAGTAATCATGTACACAAGTGGATCCACAGGACTTCCAAAGGGAGTCATGATCTCA
CATAGTAACATTATTGCTGGTATAACTGGGATGGCAGAAAGGATTCCAGAACTAGGAGAG
GAAGATGTCTACATTGGATATTTGCCTCTGGCCCATGTTCTAGAATTAAGTGCTGAGCTT
GTCTGTCTTTCTCACGGATGCCGCATTGGTTACTCTTCACCACAGACTTTAGCAGATCAG
TCTTCAAAAATTAAAAAAGGAAGCAAAGGGGATACATCCATGTTGAAACCAACACTGATG
GCAGCAGTTCCGGAAATCATGGATCGGATCTACAAAAATGTCATGAATAAAGTCAGTGAA
ATGAGTAGTTTTCAACGTAATCTGTTTATTCTGGCCTATAATTACAAAATGGAACAGATT
TCAAAAGGACGTAATACTCCACTGTGCGACAGCTTTGTTTTCCGGAAAGTTCGAAGCTTG
CTAGGGGGAAATATTCGTCTCCTGTTGTGTGGTGGCGCTCCACTTTCTGCAACCACGCAG
CGATTCATGAACATCTGTTTCTGCTGTCCTGTTGGTCAGGGATACGGGCTCACTGAATCT
GCTGGGGCTGGAACAATTTCCGAAGTGTGGGACTACAATACTGGCAGAGTGGGAGCACCA
TTAGTTTGCTGTGAAATCAAATTAAAAAACTGGGAGGAAGGTGGATACTTTAATACTGAT
AAGCCACACCCCAGGGGTGAAATTCTTATTGGGGGCCAAAGTGTGACAATGGGGTACTAC
AAAAATGAAGCAAAAACAAAAGCTGATTTCTCTGAAGATGAAAATGGACAAAGGTGGCTC
TGTACTGGGGATATTGGAGAGTTTGAACCCGATGGATGCTTAAAGATTATTGATCGTAAA
AAGGACCTTGTAAAACTACAGGCAGGGGAATATGTTTCTCTTGGGAAAGTAGAGGCAGCT
TTGAAGAATCTTCCACTAGTAGATAACATTTGTGCATATGCAAACAGTTATCATTCTTAT
GTCATTGGATTTGTTGTGCCAAATCAAAAGGAACTAACTGAACTAGCTCGAAAGAAAGGA
CTTAAAGGGACTTGGGAGGAGCTGTGTAACAGTTGTGAAATGGAAAATGAGGTACTTAAA
GTGCTTTCCGAAGCTGCTATTTCAGCAAGTCTGGAAAAGTTTGAAATTCCAGTAAAAATT
CGTTTGAGTCCTGAACCGTGGACCCCTGAAACTGGTCTGGTGACAGATGCCTTCAAGCTG
AAACGCAAAGAGCTTAAAACACATTACCAGGCGGACATTGAGCGAATGTATGGAAGAAAA
TAA

# Metabolic_Enzyme_107_GenBank_ID_Gene:
D89053

# Metabolic_Enzyme_107_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_107_Locus:
2q34-q35

# Metabolic_Enzyme_107_SNPs:
rs795876; rs12474230; rs795882; rs12998074; rs795888; rs6722420; rs4674719; rs10932977; rs795875; rs2119160; rs1011965; rs7561624; rs795884; rs795886; rs12105595; rs1046108; rs16864214; rs4477904; rs6719075; rs12471915; rs7596551; rs10439277; rs795892; rs10804309; rs12624299; rs795891; rs705727; rs10469668; rs7576552; rs12104813; rs6717500; rs4674730; rs795890; rs17780761; rs13031097; rs795881; rs795895; rs795894; rs1046109; rs795878; rs12620099; rs12468021; rs10183313; rs16864223; rs795883; rs2254744; rs795879; rs16864217; rs17838618; rs795887; rs4542842; rs12694584; rs795880; rs16864221; rs6718223; rs12694585; rs4674718; rs6718830; rs795889; rs11679363; rs2254743; rs16864237; rs16864201; rs17176871; rs16864206; rs13414173; rs17780803; rs4674729; rs4674720; rs795893; rs795874; rs1866661; rs6756107; rs3768979; rs1014280; rs2165231; rs1485; rs6726737; rs11689975; rs10932980; rs12694586; rs6756323; rs4674723; rs4674724; rs13393796; rs1440061; rs6734103; rs4674727; rs10202154; rs2028384; rs10755041; rs10195273; rs935025; rs1440060; rs6436359; rs10804310; rs4674721; rs2119161; rs6758680; rs6436362; rs2119157; rs6436361; rs13031981; rs10498144; rs7590226; rs6705231; rs10204692; rs11674966; rs17781935; rs2165235; rs11695891; rs11674961; rs3213905; rs11674416; rs1550419; rs6722786; rs4674722; rs7602022; rs13012131; rs6727725; rs36048754; rs935030; rs7606898; rs10755042; rs10755043; rs4273205; rs1046032; rs34626661; rs1802541; rs17854140; rs34336387; rs13000358; rs5838968; rs34577259; rs36065921; rs28656308; rs28699168; rs3997656; rs28493822; rs36096049; rs795877; rs11461046; rs35213364; rs8179626; rs10187725; rs28400352; rs3076926; rs35191505; rs2119159; rs35891556; rs33994644; rs28649204; rs2100065; rs28717371; rs35119789; rs35688859; rs13029225; rs13032040; rs795885; rs745246; rs4674714; rs10469669; rs35221740; rs11331027; rs33980054; rs10469670; rs28377223; rs28558419; rs8179628; rs28528808; rs35528989; rs34361522; rs4673042; rs10605018; rs28663659; rs28404973; rs34528925; rs35202862; rs28398302; rs6739444; rs13010036; rs6721226; rs28532346; rs28498974; rs28601880; rs8179629; rs28491161; rs28690910; rs10573099; rs34892893; rs34509695; rs35385155; rs28546181; rs13028279; rs13425612; rs11449718; rs13005650; rs7563167; rs34640732; rs13400287; rs28631212; rs35656414; rs35999325; rs34580617; rs10604823; rs3076928; rs10564643; rs13400197; rs10196623; rs34468357; rs5838967; rs35575997; rs35685810; rs35366410; rs34965512; rs5838965; rs28622494; rs10932976; rs1139961; rs11315051; rs28489259; rs13002795; rs11412579; rs35585948; rs10623105; rs13034896; rs5838966; rs33995774; rs1087865; rs35812917; rs7557653; rs10169861; rs10469667; rs28425616; rs28705099; rs35845392; rs3997652; rs28661727; rs5838969; rs13006287; rs9646876; rs13005876; rs1071621; rs28626732; rs34307763; rs28449223; rs13003291; rs28731005; rs11674956; rs6728234; rs35747682; rs16864233; rs5838970; rs6758013; rs11692000; rs7573347; rs28524829; rs11357504; rs4674726; rs35451327; rs35957788; rs35249874; rs34975444; rs1550420; rs5838972; rs10427163; rs11674957; rs35090606; rs34279120; rs34095647; rs5838973; rs34861997; rs4674725; rs11389330; rs36064590; rs1486; rs10607565; rs11460847; rs13413567; rs10932978; rs34262851; rs17177230; rs11402748; rs35079082; rs34016050; rs11675672; rs6436360; rs35177160; rs2165232; rs7573229; rs35356121; rs28718147; rs11891410; rs10932979; rs7595881; rs34431912; rs4521033; rs1550426; rs35965037; rs10172473; rs35381336; rs11691999; rs2165236; rs12623448; rs10804312; rs10174348; rs34942789; rs34403932; rs13413471; rs5838971; rs35545652; rs34031078; rs6739824; rs4353643; rs35350949; rs35644461; rs35218915; rs6744694; rs12233118; rs11397544; rs35724769; rs34054473; rs10170523; rs10183850; rs13009194; rs13388639; rs1473290; rs2034253; rs2053717; rs34780684; rs35355564; rs4330101; rs6436363; rs6436364; rs6547; rs6751070; rs7575760; rs7592063

# Metabolic_Enzyme_107_General_References:
9177793; 11707336

# Metabolic_Enzyme_107_References:
Not Available

# Metabolic_Enzyme_108_ID:
5920

# Metabolic_Enzyme_108_Name:
Leucyl-tRNA synthetase, cytoplasmic

# Metabolic_Enzyme_108_Synonyms:
Leucine--tRNA ligase; LeuRS

# Metabolic_Enzyme_108_Gene_Name:
LARS

# Metabolic_Enzyme_108_Protein_Sequence:
>LeucyltRNA synthetase, cytoplasmic
MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH

# Metabolic_Enzyme_108_Number_of_Residues:
1176

# Metabolic_Enzyme_108_Molecular_Weight:
134468

# Metabolic_Enzyme_108_Theoretical_pI:
7.31

# Metabolic_Enzyme_108_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  leucine-tRNA ligase activity
 ||
>>>
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  macromolecule biosynthesis
Process:  protein biosynthesis
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_108_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_108_Specific_Function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_108_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_108_Reaction:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

# Metabolic_Enzyme_108_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF09334:tRNA-synt_1g

# Metabolic_Enzyme_108_Signals:
None

# Metabolic_Enzyme_108_Transmembrane_Regions:
None

# Metabolic_Enzyme_108_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_108_EC_Link:
EC 6.1.1.4

# Metabolic_Enzyme_108_GenBank_ID_Protein:
7804450

# Metabolic_Enzyme_108_SwissProt_ID:
SYLC_HUMAN (Q9P2J5)

# Metabolic_Enzyme_108_swissprot_Name:
Not Available

# Metabolic_Enzyme_108_Genecard_id:
LARS

# Metabolic_Enzyme_108_Geneatlas_id:
LARS

# Metabolic_Enzyme_108_hgnc_id:
HGNC:6512

# Metabolic_Enzyme_108_PDB_ID:
Not Available

# Metabolic_Enzyme_108_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_108_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_108_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_108_Gene_Sequence:
>3531 bp
ATGGCGGAAAGAAAAGGAACAGCCAAAGTGGACTTTTTGAAGAAGATTGAGAAAGAAATC
CAACAGAAATGGGATACTGAGAGAGTGTTTGAGGTCAATGCATCTAATTTAGAGAAACAG
ACCAGCAAGGGCAAGTATTTTGTAACCTTCCCATATCCATATATGAATGGACGCCTTCAT
TTGGGACACACGTTTTCTTTATCCAAATGTGAGTTTGCTGTAGGGTACCAGCGATTGAAA
GGAAAATGTTGTCTGTTTCCCTTTGGCCTGCACTGTACTGGAATGCCTATTAAGGCATGT
GCTGATAAGTTGAAAAGAGAAATAGAGCTGTATGGTTGCCCCCCTGATTTTCCAGATGAA
GAAGAGGAAGAGGAAGAAACCAGTGTTAAAACAGAAGATATAATAATTAAGGATAAAGCT
AAAGGAAAAAAGAGTAAAGCTGCTGCTAAAGCTGGATCTTCTAAATACCAGTGGGGCATT
ATGAAATCCCTTGGCCTGTCTGATGAAGAGATAGTAAAATTTTCTGAAGCAGAACATTGG
CTTGATTATTTCCCGCCACTGGCTATTCAGGATTTAAAAAGAATGGGTTTGAAGGTAGAC
TGGCGTCGTTCCTTCATCACCACTGATGTTAATCCTTACTATGATTCATTTGTCAGATGG
CAATTTTTAACATTAAGAGAAAGAAACAAAATTAAATTTGGGAAGCGGTATACAATTTAC
TCTCCGAAAGATGGACAGCCTTGCATGGATCATGATAGACAAACTGGAGAGGGTGTTGGA
CCTCAGGAATATACTTTACTCAAATTGAAGGCGCTTGAGCCATACCCATCTAAATTAAGT
GGCCTGAAAGGTAAAAATATTTTCTTGGTGGCTGCTACTCTCAGACCTGAGACCATGTTT
GGGCAGACAAATTGTTGGGTTCGTCCTGATATGAAGTACATTGGATTTGAGACGGTGAAT
GGTGATATATTCATCTGTACCCAAAAAGCAGCCAGGAATATGTCATACCAGGGCTTTACC
AAAGACAATGGCGTGGTGCCTGTTGTTAAGGAATTAATGGGGGAGGAAATTCTTGGTGCA
TCACTTTCTGCACCTTTAACATCATACAAGGTGATCTATGTTCTCCCAATGCTAACTATT
AAGGAGGATAAAGGCACTGGTGTGGTTACAAGTGTTCCTTCCGACTCCCCTGATGATATT
GCTGCCCTCAGAGACTTGAAGAAAAAGCAAGCCTTACGAGCAAAATATGGAATTAGAGAT
GACATGGTCTTGCCATTTGAGCCGGTGCCAGTCATTGAAATCCCAGGTTTTGGAAATCTT
TCTGCTGTAACCATTTGTGATGAGTTGAAAATTCAGAGCCAGAATGACCGGGAAAAACTT
GCAGAAGCAAAGGAGAAGATATATCTAAAAGGATTTTATGAGGGTATCATGTTGGTGGAT
GGATTTAAAGGACAGAAGGTTCAAGATGTAAAGAAGACTATTCAGAAAAAGATGATTGAC
GCTGGAGATGCACTTATTTACATGGAACCAGAGAAACAAGTGATGTCCAGGTCGTCAGAT
GAATGTGTTGTGGCTCTGTGTGACCAGTGGTACTTGGATTATGGAGAAGAGAATTGGAAG
AAACAGACATCTCAGTGCTTGAAGAACCTGGAAACATTCTGTGAGGAGACCAGGAGGAAT
TTTGAAGCCACCTTAGGTTGGCTACAAGAACATGCTTGCTCAAGAACTTATGGTCTAGGC
ACTCACCTGCCTTGGGATGAGCAGTGGCTGATTGAATCACTTTCTGACTCCACTATTTAC
ATGGCATTTTACACAGTTGCACACCTATTGCAGGGGGGTAACTTGCATGGACAGGCAGAG
TCTCCGCTGGGCATTAGACCGCAACAGATGACCAAGGAAGTTTGGGATTATGTTTTCTTC
AAGGAGGCTCCATTTCCTAAGACTCAGATTGCAAAGGAAAAATTAGATCAGTTAAAGCAG
GAGTTTGAATTCTGGTATCCTGTTGATCTTCGCGTCTCTGGCAAGGATCTTGTTCCAAAT
CATCTTTCATATTACCTTTATAATCATGTGGCTATGTGGCCGGAACAAAGTGATAAATGG
CCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCC
ACAGGCAACTTCCTCACTTTGACCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGT
TTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAGCCATGGCA
GATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAAC
TGGGACAGCCTAAGAAGTGGTCCTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAA
TTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTAAAGAAGCT
TTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTG
GAAGGGATGCACAGAGAACTTGTGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCT
CCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTGACTCAATT
ATGAATGCTTCATGGCCTGTGGCAGGTCCTGTGGATGAAGTTTTAATACACTCCTCACAG
TATCTTATGGAAGTAACACATGACCTTAGACTACGACTCAAGAACTATATGATGCCAGCT
AAAGGGAAGAAGACCGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCATCTATGTG
GCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAG
GCCAATAACGGAAAACTGCCTGACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCA
GAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGGAAAATCTG
GAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTT
ATGGAGAATATAGTCTATCTGACTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTT
GCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCACTTAATGTT
TTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCAC
TTCTCAACCAAAATTGAAATCAAGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTA
ATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGATTTGATGAT
CCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCC
ATTTCTGAGCATGCTGTTTTCAATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAG
AATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAA

# Metabolic_Enzyme_108_GenBank_ID_Gene:
D84223

# Metabolic_Enzyme_108_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_108_Locus:
5q32

# Metabolic_Enzyme_108_SNPs:
rs10988; rs2895647; rs17104257; rs3763373; rs17493851; rs12188941; rs1395277; rs1054020; rs1395276; rs2963918; rs3828935; rs10515564; rs7728381; rs2962511; rs2963913; rs11951553; rs3822623; rs2939536; rs12153109; rs11948314; rs2963919; rs2063005; rs4413574; rs1911112; rs11167931; rs4705438; rs17104255; rs3797628; rs13178370; rs2963911; rs11952228; rs17492893; rs11167932; rs2962512; rs2292172; rs2939535; rs2962515; rs2895649; rs2939538; rs11954750; rs17492851; rs2963921; rs2292173; rs17492950; rs3749994; rs11958630; rs2962500; rs17426775; rs17427286; rs2962505; rs2400209; rs17428570; rs2963924; rs17500483; rs17428100; rs11948180; rs2962514; rs11953517; rs11954977; rs2400211; rs2895648; rs11954083; rs17500504; rs2963914; rs12186358; rs17426845; rs2963910; rs13153675; rs17428465; rs13161075; rs2963915; rs17427691; rs13161659; rs6871866; rs11955557; rs11949703; rs13171828; rs13162640; rs2963922; rs13178516; rs11948017; rs13161233; rs11954870; rs17104266; rs2962510; rs17500456; rs1911113; rs13182567; rs13161036; rs11167934; rs13154547; rs11955635; rs4705119; rs11955695; rs17104254; rs17104276; rs17104260; rs11954923; rs2939539; rs13176915; rs2939522; rs2895650; rs2963920; rs2939525; rs11949351; rs13186694; rs12189385; rs11167933; rs2962506; rs3812244; rs11957199; rs33914983; rs17104264; rs2939521; rs11741611; rs13162233; rs6884711; rs17493090; rs2962503; rs9686750; rs883639; rs2962513; rs11952281; rs12522922; rs17104268; rs13178840; rs2963923; rs11959805; rs13185805; rs2939520; rs2962507; rs13180113; rs10037835; rs2939527; rs2962502; rs2939537; rs11960724; rs11952340; rs12153238; rs17104250; rs2015248; rs17428724; rs4913065; rs17428647; rs16742; rs13186701; rs11540215; rs4913066; rs17104247; rs4913067; rs34823161; rs4549582; rs11540214; rs11540217; rs34192761; rs35861595; rs13171596; rs36005893; rs2108447; rs35008800; rs12055029; rs34774165; rs36095232; rs13159380; rs10225; rs12055173; rs6882243; rs35736365; rs10660135; rs2939530; rs2962509; rs1395275; rs11744010; rs35302388; rs34203668; rs2063004; rs2962504; rs10650026; rs35658996; rs13172010; rs3840516; rs34633760; rs13183171; rs2108448; rs34461274; rs2963917; rs3062189; rs11750558; rs34794547; rs2963916; rs35044843; rs2962508; rs34787435; rs6865204; rs13157279; rs13184702; rs34908228; rs35814921; rs28560221; rs10223249; rs34529192; rs34896615; rs35868039; rs2895651; rs34482773; rs35858532; rs34204322; rs2939528; rs12521535; rs34272709; rs35754955; rs35048686; rs35048100; rs35659985; rs34049009; rs13179517; rs7717715; rs35421875; rs4705398; rs2939531; rs2063003; rs34672485; rs2962501; rs13178755; rs34201197; rs11957830; rs6860704; rs11467105; rs33930619; rs2400210; rs34064705; rs11453686; rs35641727; rs2963908; rs35986267; rs34127596; rs3995492; rs13190467; rs35626574; rs10076614; rs4443471; rs11953039; rs35424128; rs10068337; rs34581962; rs35320822; rs35080569; rs2963909; rs4705440; rs35676277; rs36122632; rs10571244; rs35449023; rs36098188; rs10584471; rs34986741; rs2939526; rs35821418; rs34688497; rs36059140; rs34590254; rs4546439; rs13164711; rs35262581; rs35238125; rs12055030; rs9325003; rs13189448; rs2939529; rs34643439; rs6894533; rs34345997; rs35436549; rs13176784; rs10070154; rs13164882; rs7734517; rs4323275; rs34683303; rs34794113; rs2963907; rs10214195; rs35545858; rs35163711; rs35614174; rs33955938; rs35339866; rs35581472; rs6881275; rs36102990; rs36070404; rs35825928; rs35131794; rs28449376; rs35849077; rs34014355; rs11748295; rs4345358; rs34090359; rs34662124; rs28558310; rs34452275; rs28579770; rs34706167; rs11957888; rs35690977; rs35723465; rs35379206; rs34355060; rs34342344; rs11321164; rs11957745; rs35749752; rs34404385; rs34658033; rs35421100; rs35185759; rs10655743; rs10583489; rs35869904; rs34272346; rs4415127; rs28587686; rs7733143; rs34700156; rs34428386; rs13170112; rs33910134; rs11958216; rs13154735; rs13184596; rs13170127; rs2939532; rs5871957; rs13170115; rs10524796; rs33936514; rs3836839; rs34405762; rs3062188; rs7356532; rs35494851; rs11948951; rs11957998; rs12187128; rs12187913; rs12188066; rs12188581; rs13174055; rs17104298; rs17500927; rs2063002; rs2906815; rs2939534; rs2962516; rs2962544; rs2962545; rs2963935; rs2963937; rs34170515; rs34181648; rs35652702; rs4913064; rs6875971; rs7443214; rs7728631

# Metabolic_Enzyme_108_General_References:
10718198

# Metabolic_Enzyme_108_References:
Not Available

# Metabolic_Enzyme_109_ID:
5921

# Metabolic_Enzyme_109_Name:
Ubiquitin-conjugating enzyme E2 C

# Metabolic_Enzyme_109_Synonyms:
Ubiquitin-protein ligase C; Ubiquitin carrier protein C; UbcH10

# Metabolic_Enzyme_109_Gene_Name:
UBE2C

# Metabolic_Enzyme_109_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
CMASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNL
FKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK
EKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP


# Metabolic_Enzyme_109_Number_of_Residues:
179

# Metabolic_Enzyme_109_Molecular_Weight:
19652

# Metabolic_Enzyme_109_Theoretical_pI:
7.50

# Metabolic_Enzyme_109_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_109_General_Function:
Not Available

# Metabolic_Enzyme_109_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the destruction of mitotic cyclins

# Metabolic_Enzyme_109_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_109_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_109_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_109_Signals:
None

# Metabolic_Enzyme_109_Transmembrane_Regions:
None

# Metabolic_Enzyme_109_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_109_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_109_GenBank_ID_Protein:
2062373

# Metabolic_Enzyme_109_SwissProt_ID:
UBE2C_HUMAN (O00762)

# Metabolic_Enzyme_109_swissprot_Name:
Not Available

# Metabolic_Enzyme_109_Genecard_id:
UBE2C

# Metabolic_Enzyme_109_Geneatlas_id:
UBE2C

# Metabolic_Enzyme_109_hgnc_id:
HGNC:15937

# Metabolic_Enzyme_109_PDB_ID:
1I7K

# Metabolic_Enzyme_109_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_109_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_109_Subcellular_Location:
Not Available

# Metabolic_Enzyme_109_Gene_Sequence:
>540 bp
ATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCT
GAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATG
ACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTC
AAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTATATGAAGACCTGAGGTATAAG
CTCTCGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTTCCTCACG
CCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGAA
AAGTGGTCTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGA
GAACCCAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCTTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCCTGA


# Metabolic_Enzyme_109_GenBank_ID_Gene:
U73379

# Metabolic_Enzyme_109_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_109_Locus:
20q13.12

# Metabolic_Enzyme_109_SNPs:
rs440789; rs382494; rs6017695; rs4458269; rs910396; rs2868350; rs6104355; rs445503; rs368622; rs11537645; rs34158793; rs34343212; rs7352110; rs6065895; rs11537646; rs6124745; rs10644383; rs5841608; rs11697338; rs3080107; rs10688619; rs35875372; rs3080105; rs7346644; rs7344079; rs6017694; rs10644382; rs35855523; rs35590450; rs35674509; rs6130939; rs35783500; rs6094213; rs8122973; rs11086982; rs11906429; rs12624428; rs12625621; rs13038132; rs1804548; rs1966172; rs380973; rs3848711; rs3848712; rs389417; rs390386; rs399672; rs434227; rs4629; rs4812963; rs4812964; rs574268; rs6017697; rs6032552; rs6073920; rs6073923; rs6073924; rs6094214; rs6104356; rs6130938; rs6130940; rs6514062; rs6514063; rs7272593; rs7348743; rs8124479; rs8860

# Metabolic_Enzyme_109_General_References:
9122200; 11780052; 11927573

# Metabolic_Enzyme_109_References:
Not Available

# Metabolic_Enzyme_110_ID:
5922

# Metabolic_Enzyme_110_Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

# Metabolic_Enzyme_110_Synonyms:
DPDE2; PDE46

# Metabolic_Enzyme_110_Gene_Name:
PDE4A

# Metabolic_Enzyme_110_Protein_Sequence:
>cAMPspecific 3',5'cyclic phosphodiesterase 4
AMEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERER
QPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPG
RSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVT
PFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELD
WCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

# Metabolic_Enzyme_110_Number_of_Residues:
886

# Metabolic_Enzyme_110_Molecular_Weight:
98144

# Metabolic_Enzyme_110_Theoretical_pI:
4.87

# Metabolic_Enzyme_110_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_110_General_Function:
Not Available

# Metabolic_Enzyme_110_Specific_Function:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

# Metabolic_Enzyme_110_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_110_Reaction:
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

# Metabolic_Enzyme_110_Pfam_Domain_Function:
PF00233:PDEase_I

# Metabolic_Enzyme_110_Signals:
None

# Metabolic_Enzyme_110_Transmembrane_Regions:
None

# Metabolic_Enzyme_110_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_110_EC_Link:
EC 3.1.4.17

# Metabolic_Enzyme_110_GenBank_ID_Protein:
347120

# Metabolic_Enzyme_110_SwissProt_ID:
PDE4A_HUMAN (P27815)

# Metabolic_Enzyme_110_swissprot_Name:
Not Available

# Metabolic_Enzyme_110_Genecard_id:
PDE4A

# Metabolic_Enzyme_110_Geneatlas_id:
PDE4A

# Metabolic_Enzyme_110_hgnc_id:
HGNC:8780

# Metabolic_Enzyme_110_PDB_ID:
Not Available

# Metabolic_Enzyme_110_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_110_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_110_Subcellular_Location:
Isoform 4:Membrane; peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes

# Metabolic_Enzyme_110_Gene_Sequence:
>2661 bp
ATGGAACCCCCGACCGTCCCCTCGGAAAGGAGCCTGTCTCTGTCACTGCCCGGGCCCCGG
GAGGGCCAGGCCACCCTGAAGCCTCCCCCGCAGCACCTGTGGCGGCAGCCTCGGACCCCC
ATCCGTATCCAGCAGCGCGGCTACTCCGACAGCGCGGAGCGCGCCGAGCGGGAGCGGCAG
CCGCACCGGCCCATAGAGCGCGCCGATGCCATGGACACCAGCGACCGGCCCGGCCTGCGC
ACGACCCGCATGTCCTGGCCCTCGTCCTTCCATGGCACTGGCACCGGCAGCGGCGGCGCG
GGCGGAGGCAGCAGCAGGCGCTTCGAGGCAGAGAATGGGCCGACACCATCTCCTGGCCGC
AGCCCCCTGGACTCGCAGGCGAGCCCAGGACTCGTGCTGCACGCCGGGGCGGCCACCAGC
CAGCGCCGGGAGTCCTTCCTGTACCGCTCAGACAGCGACTATGACATGTCACCCAAGACC
ATGTCCCGGAACTCATCGGTCACCAGCGAGGCGCACGCTGAAGACCTCATCGTAACACCA
TTTGCTCAGGTGCTGGCCAGCCTCCGGAGCGTCCGTAGCAACTTCTCACTCCTGACCAAT
GTGCCCGTTCCCAGTAACAAGCGGTCCCCGCTGGGCGGCCCCACCCCTGTCTGCAAGGCC
ACGCTGTCAGAAGAAACGTGTCAGCAGTTGGCCCGGGAGACTCTGGAGGAGCTGGACTGG
TGTCTGGAGCAGCTGGAGACCATGCAGACCTATCGCTCTGTCAGCGAGATGGCCTCGCAC
AAGTTCAAAAGGATGTTGAACCGTGAGCTCACACACCTGTCAGAAATGAGCAGGTCCGGA
AACCAGGTCTCAGAGTACATTTCCACAACATTCCTGGACAAACAGAATGAAGTGGAGATC
CCATCACCCACGATGAAGGAACGAGAAAAACAGCAAGCGCCGCGACCAAGACCCTCCCAG
CCGCCCCCGCCCCCTGTACCACACTTACAGCCCATGTCCCAAATCACAGGGTTGAAAAAG
TTGATGCATAGTAACAGCCTGAACAACTCTAACATTCCCCGATTTGGGGTGAAGACCGAT
CAAGAAGAGCTCCTGGCCCAAGAACTGGAGAACCTGAACAAGTGGGGCCTGAACATCTTT
TGCGTGTCGGATTACGCTGGAGGCCGCTCACTCACCTGCATCATGTACATGATATTCCAG
GAGCGGGACCTGCTGAAGAAATTCCGCATCCCGGTGGACACGATGGTGACATACATGCTG
ACGCTGGAGGATCACTACCACGCTGACGTGGCCTACCATAACAGCCTGCACGCAGCTGAC
GTGCTGCAGTCCACCCACGTACTGCTGGCCACGCCTGCACTAGATGCAGTGTTCACGGAC
CTGGAGATTCTCGCCGCCCTCTTCGCGGCTGCCATCCACGATGTGGATCACCCTGGGGTC
TCCAACCAGTTCCTCATCAACACCAATTCGGAGCTGGCGCTCATGTACAACGATGAGTCG
GTGCTCGAGAATCACCACCTGGCCGTGGGCTTCAAGCTGCTGCAGGAGGACAACTGCGAC
ATCTTCCAGAACCTCAGCAAGCGCCAGCGGCAGAGCCTACGCAAGATGGTCATCGACATG
GTGCTGGCCACGGACATGTCCAAGCACATGACCCTCCTGGCTGACCTGAAGACCATGGTG
GAGACCAAGAAAGTGACCAGCTCAGGGGTCCTCCTGCTAGATAACTACTCCGACCGCATC
CAGGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAG
CTGTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAG
CGCGAGCGTGGCATGGAAATCAGCCCCATGTGTGACAAGCACACTGCCTCCGTGGAGAAG
TCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTT
GTCCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTAC
AGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTCAAGGGGGCCAGGCCAC
CCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAA
ATATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCA
GGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATCCCCGGCCCAGGAGTCG
TTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACA
CAGCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAG
GAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGCTCTTCAAAGCCCCCTT
CTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCC
TCCACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGT
GCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGCTCCTGGTGGCGGGGGG
TCAGGTGGAGACCCTACCTGA

# Metabolic_Enzyme_110_GenBank_ID_Gene:
L20965

# Metabolic_Enzyme_110_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_110_Locus:
19p13.2

# Metabolic_Enzyme_110_SNPs:
rs1051738; rs2230190; rs2230189; rs7256672; rs3745258; rs4804134; rs2358681; rs10416143; rs7247481; rs7343073; rs1194098; rs11672021; rs1051736; rs3192116; rs35473931; rs35610871; rs3745260; rs3192124; rs3833220; rs7253115; rs12985883; rs3745259; rs34212445; rs2569755; rs35371416; rs12983959; rs2569756; rs2735389; rs5827100; rs11666164; rs10404367; rs12975524; rs34214178; rs35888394; rs10411816; rs34675916; rs12610073; rs35398762; rs34222169; rs33984348; rs34278258; rs35452057; rs12975511; rs34861232; rs12981823; rs12982685; rs1194097; rs4804504; rs35757023; rs12982917; rs35214617; rs34230915; rs4804503; rs35368894; rs12981546; rs12975530; rs3936362; rs35867809; rs2735390; rs10423080; rs2569758; rs2569765; rs12978292; rs2569766; rs12978315; rs2569757; rs2569763; rs12978301; rs2569759; rs2569761; rs12978366; rs2569764; rs2569762; rs12978582; rs2569760; rs12980133; rs35084366; rs12980191; rs12981218; rs35715070; rs34519818; rs35937838; rs10416653; rs11671269; rs2569767; rs2569768; rs4804505; rs8105602

# Metabolic_Enzyme_110_General_References:
8413254; 9677330; 2160582; 7772058; 7888306

# Metabolic_Enzyme_110_References:
Not Available

# Metabolic_Enzyme_111_ID:
5313

# Metabolic_Enzyme_111_Name:
Ectonucleoside triphosphate diphosphohydrolase 1

# Metabolic_Enzyme_111_Synonyms:
NTPDase 1; Ecto-ATP diphosphohydrolase; ATPDase; Lymphoid cell activation antigen; Ecto-apyrase; CD39 antigen

# Metabolic_Enzyme_111_Gene_Name:
ENTPD1

# Metabolic_Enzyme_111_Protein_Sequence:
>Ectonucleoside triphosphate diphosphohydrolase 1
MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHT
SLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQ
HQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWI
TINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFR
LYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTP
CTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAF
SAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYIL
SLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFL
MVLFSLVLFTVAIIGLLIFHKPSYFWKDMV

# Metabolic_Enzyme_111_Number_of_Residues:
510

# Metabolic_Enzyme_111_Molecular_Weight:
57965

# Metabolic_Enzyme_111_Theoretical_pI:
6.29

# Metabolic_Enzyme_111_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_111_General_Function:
Not Available

# Metabolic_Enzyme_111_Specific_Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well

# Metabolic_Enzyme_111_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_111_Reaction:
ATP + 2 H2O = AMP + 2 phosphate

# Metabolic_Enzyme_111_Pfam_Domain_Function:
PF01150:GDA1_CD39

# Metabolic_Enzyme_111_Signals:
None

# Metabolic_Enzyme_111_Transmembrane_Regions:
17-37
479-499

# Metabolic_Enzyme_111_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_111_EC_Link:
EC 3.6.1.5

# Metabolic_Enzyme_111_GenBank_ID_Protein:
765256

# Metabolic_Enzyme_111_SwissProt_ID:
ENTP1_HUMAN (P49961)

# Metabolic_Enzyme_111_swissprot_Name:
Not Available

# Metabolic_Enzyme_111_Genecard_id:
ENTPD1

# Metabolic_Enzyme_111_Geneatlas_id:
ENTPD1

# Metabolic_Enzyme_111_hgnc_id:
HGNC:3363

# Metabolic_Enzyme_111_PDB_ID:
Not Available

# Metabolic_Enzyme_111_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_111_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_111_Subcellular_Location:
Membrane; multi-pass membrane protein (Potential)

# Metabolic_Enzyme_111_Gene_Sequence:
>1533 bp
ATGGAAGATACAAAGGAGTCTAACGTGAAGACATTTTGCTCCAAGAATATCCTAGCCATC
CTTGGCTTCTCCTCTATCATAGCTGTGATAGCTTTGCTTGCTGTGGGGTTGACCCAGAAC
AAAGCATTGCCAGAAAACGTTAAGTATGGGATTGTGCTGGATGCGGGTTCTTCTCACACA
AGTTTATACATCTATAAGTGGCCAGCAGAAAAGGAGAATGACACAGGCGTGGTGCATCAA
GTAGAAGAATGCAGGGTTAAAGGTCCTGGAATCTCAAAATTTGTTCAGAAAGTAAATGAA
ATAGGCATTTACCTGACTGATTGCATGGAAAGAGCTAGGGAAGTGATTCCAAGGTCCCAG
CACCAAGAGACACCCGTTTACCTGGGAGCCACGGCAGGCATGCGGTTGCTCAGGATGGAA
AGTGAAGAGTTGGCAGACAGGGTTCTGGATGTGGTGGAGAGGAGCCTCAGCAACTACCCC
TTTGACTTCCAGGGTGCCAGGATCATTACTGGCCAAGAGGAAGGTGCCTATGGCTGGATT
ACTATCAACTATCTGCTGGGCAAATTCAGTCAGAAAACAAGGTGGTTCAGCATAGTCCCA
TATGAAACCAATAATCAGGAAACCTTTGGAGCTTTGGACCTTGGGGGAGCCTCTACACAA
GTCACTTTTGTACCCCAAAACCAGACTATCGAGTCCCCAGATAATGCTCTGCAATTTCGC
CTCTATGGCAAGGACTACAATGTCTACACACATAGCTTCTTGTGCTATGGGAAGGATCAG
GCACTCTGGCAGAAACTGGCCAAGGACATTCAGGTTGCAAGTAATGAAATTCTCAGGGAC
CCATGCTTTCATCCTGGATATAAGAAGGTAGTGAACGTAAGTGACCTTTACAAGACCCCC
TGCACCAAGAGATTTGAGATGACTCTTCCATTCCAGCAGTTTGAAATCCAGGGTATTGGA
AACTATCAACAATGCCATCAAAGCATCCTGGAGCTCTTCAACACCAGTTACTGCCCTTAC
TCCCAGTGTGCCTTCAATGGGATTTTCTTGCCACCACTCCAGGGGGATTTTGGGGCATTT
TCAGCTTTTTACTTTGTGATGAAGTTTTTAAACTTGACATCAGAGAAAGTCTCTCAGGAA
AAGGTGACTGAGATGATGAAAAAGTTCTGTGCTCAGCCTTGGGAGGAGATAAAAACATCT
TACGCTGGAGTAAAGGAGAAGTACCTGAGTGAATACTGCTTTTCTGGTACCTACATTCTC
TCCCTCCTTCTGCAAGGCTATCATTTCACAGCTGATTCCTGGGAGCACATCCATTTCATT
GGCAAGATCCAGGGCAGCGACGCCGGCTGGACTTTGGGCTACATGCTGAACCTGACCAAC
ATGATCCCAGCTGAGCAACCATTGTCCACACCTCTCTCCCACTCCACCTATGTCTTCCTC
ATGGTTCTATTCTCCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCAC
AAGCCTTCATATTTCTGGAAAGATATGGTATAG

# Metabolic_Enzyme_111_GenBank_ID_Gene:
S73813

# Metabolic_Enzyme_111_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_111_Locus:
10q24

# Metabolic_Enzyme_111_SNPs:
rs3793744; rs3181132; rs1342790; rs3176883; rs3181124; rs1573112; rs3176891; rs2153913; rs3176890; rs10748643; rs7077566; rs4431963; rs6584033; rs4582902; rs10882665; rs6584026; rs2185818; rs10748649; rs4075310; rs3176881; rs5014871; rs7097489; rs7919196; rs4481960; rs4918968; rs10882664; rs1891534; rs7096610; rs10509686; rs7083960; rs4322324; rs3892344; rs3181123; rs4396219; rs4512761; rs4917715; rs7921242; rs7074403; rs1891536; rs4244321; rs2861152; rs1418709; rs3181131; rs2275759; rs4075311; rs10882671; rs4917714; rs1340837; rs6584027; rs3176885; rs7088952; rs12262943; rs11598475; rs4320886; rs17111156; rs11188486; rs10882676; rs7096248; rs3929900; rs4918969; rs4551688; rs7093453; rs3897983; rs2901874; rs10882673; rs4918971; rs2901873; rs2861153; rs6584031; rs10736092; rs7893677; rs3181129; rs4917707; rs11188497; rs7088961; rs7902190; rs10882660; rs2105359; rs6584028; rs7901116; rs7913082; rs10736093; rs3176884; rs7900927; rs4614366; rs10786236; rs2901872; rs7067762; rs11188485; rs7089668; rs4409759; rs7070507; rs11595122; rs10882670; rs10786235; rs1539433; rs7100137; rs7088584; rs11818540; rs10748648; rs4336964; rs10882675; rs1342791; rs4074424; rs4918970; rs3181122; rs12767650; rs3901451; rs11816167; rs11188475; rs3181121; rs7915345; rs3176887; rs2861151; rs6584030; rs4412693; rs11594340; rs7921000; rs7894940; rs3176882; rs7898379; rs11188496; rs3181118; rs3176886; rs10882661; rs10882666; rs7901386; rs2275760; rs7090320; rs12770849; rs3181125; rs7915682; rs3901450; rs11188501; rs10786237; rs7900546; rs10748644; rs10786234; rs7915087; rs7913018; rs7894676; rs7914736; rs1935816; rs1418710; rs10748645; rs10786233; rs7069234; rs4406763; rs10882662; rs11188502; rs7915308; rs3176889; rs7095489; rs11593761; rs7082531; rs7914286; rs2861154; rs7083411; rs3176888; rs10882663; rs7920372; rs10748647; rs12780375; rs12354848; rs7476775; rs11188484; rs11188495; rs12763743; rs10882668; rs4272738; rs11188488; rs7900841; rs7921302; rs11188492; rs10786238; rs12244606; rs7915499; rs10882669; rs11188498; rs7904990; rs11592584; rs12770313; rs10882674; rs11188504; rs3181127; rs7915380; rs3176894; rs3814159; rs3176893; rs3176895; rs3176892; rs1804825; rs12240959; rs4463786; rs34293555; rs34399092; rs35135296; rs11389794; rs3980180; rs10736091; rs11407296; rs11188487; rs11597953; rs11188493; rs5787157; rs4472866; rs4539246; rs34736818; rs34473397; rs35488296; rs35597960; rs4420188; rs35620983; rs5787162; rs9663685; rs35826614; rs7900437; rs34166835; rs10585205; rs11188508; rs34177114; rs36017526; rs3181128; rs10672739; rs4581382; rs5787158; rs12354620; rs12265109; rs11188494; rs11188482; rs4433506; rs34836127; rs34248770; rs35444953; rs35537802; rs3980181; rs34907927; rs35452058; rs34858625; rs7896855; rs35809029; rs11517041; rs11188479; rs35615283; rs34279173; rs12360382; rs34421483; rs34720050; rs34980662; rs35782220; rs11574649; rs11393527; rs7909739; rs7088411; rs12572063; rs34872816; rs12258207; rs5787161; rs11188481; rs11188511; rs28542865; rs35164560; rs4917705; rs7900229; rs11527887; rs35203111; rs3897464; rs34082135; rs34627984; rs35360884; rs11188509; rs34308669; rs35650706; rs11188506; rs4325249; rs35298724; rs35859772; rs11188510; rs5787159; rs1418711; rs11574648; rs34367283; rs34925455; rs34296389; rs11188480; rs11528098; rs34873600; rs7898964; rs34863917; rs11188489; rs34997042; rs3961946; rs35748815; rs35177231; rs12357414; rs11188490; rs12355114; rs34077465; rs35535706; rs35825117; rs35417010; rs9702308; rs4481957; rs35854596; rs11188505; rs7911911; rs5787163; rs34850860; rs12782273; rs11188477; rs11188491; rs12774334; rs3897465; rs11188473; rs9664384; rs11188503; rs33998152; rs11188483; rs4402217; rs35861909; rs35700869; rs3961947; rs35516259; rs11498722; rs5787160; rs34143181; rs10736094; rs11188466; rs11188469; rs11188471; rs11188512; rs11188513; rs11188514; rs12358481; rs12761960; rs12775598; rs12781189; rs17462179; rs17553401; rs1935815; rs2051052; rs2096218; rs2153914; rs2226163; rs3181114; rs3181115; rs3181116; rs3192654; rs34630379; rs34793678; rs4918966; rs6584022; rs6584023; rs7086986; rs7090630; rs7096317; rs7098750; rs7100644; rs7923971

# Metabolic_Enzyme_111_General_References:
7930580; 8996251; 10405171; 8529670; 9846014; 8955160; 8626624; 10636909

# Metabolic_Enzyme_111_References:
Not Available

# Metabolic_Enzyme_112_ID:
5923

# Metabolic_Enzyme_112_Name:
Valyl-tRNA synthetase

# Metabolic_Enzyme_112_Synonyms:
Valine--tRNA ligase; ValRS; Protein G7a

# Metabolic_Enzyme_112_Gene_Name:
VARS

# Metabolic_Enzyme_112_Protein_Sequence:
>ValyltRNA synthetase
MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPAL
EQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALG
LRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPA
RRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKK
REKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSY
SPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAI
QDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWK
EEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCT
LNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIET
MLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQND
YEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVV
PLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWC
ISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISL
QQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKL
TGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVE
KAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFA
LRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLY
ELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMP
QAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVAD
EATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARE
LGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALF
QKML

# Metabolic_Enzyme_112_Number_of_Residues:
1264

# Metabolic_Enzyme_112_Molecular_Weight:
140477

# Metabolic_Enzyme_112_Theoretical_pI:
7.63

# Metabolic_Enzyme_112_GO_Classification:
>>>
Function:  valine-tRNA ligase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
 ||
>>>
Process:  valyl-tRNA aminoacylation
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_112_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_112_Specific_Function:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)

# Metabolic_Enzyme_112_Pathway:
map00290  Valine, leucine and isoleucine biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_112_Reaction:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)

# Metabolic_Enzyme_112_Pfam_Domain_Function:
PF08264:Anticodon_1;
PF00043:GST_C;
PF02798:GST_N;
PF00133:tRNA-synt_1

# Metabolic_Enzyme_112_Signals:
None

# Metabolic_Enzyme_112_Transmembrane_Regions:
None

# Metabolic_Enzyme_112_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_112_EC_Link:
EC 6.1.1.9

# Metabolic_Enzyme_112_GenBank_ID_Protein:
31545

# Metabolic_Enzyme_112_SwissProt_ID:
SYV_HUMAN (P26640)

# Metabolic_Enzyme_112_swissprot_Name:
Not Available

# Metabolic_Enzyme_112_Genecard_id:
VARS

# Metabolic_Enzyme_112_Geneatlas_id:
VARS

# Metabolic_Enzyme_112_hgnc_id:
HGNC:12651

# Metabolic_Enzyme_112_PDB_ID:
Not Available

# Metabolic_Enzyme_112_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_112_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_112_Subcellular_Location:
Not Available

# Metabolic_Enzyme_112_Gene_Sequence:
>3798 bp
ATGTCCACCCTCTACGTCTCCCCTCACCCAGATGCCTTCCCCAGCCTCCGAGCCCTCATA
GCCGCTCGCTATGGGGAGGCTGGGGAGGGTCCCGGATGGGGAGGAGCCCACCCCCGCATC
TGTCTCCAGCCACCCCCGACTAGCAGGACTAGCTTTCCCCCACCCCGCCTGCCGGCCCTG
GAGCAGGGGCCCGGTGGGCTCTGGGTGTGGGGGGCCACGGCTGTGGCCCAGCTGCTGTGG
CCAGCAGGCCTGGGGGGCCCAGGGGGCAGCCGGGCGGCTGTCCTTGTCCAACAGTGGGTC
AGTTACGCCGACACGGAGTTAATACCAGCTGCCTGTGGAGCAACGCTGCCGGCCCTGGGA
CTCCGAAGCTCGGCCCAGGACCCCCAGGCTGTGCTGGGGGCCCTGGGCAGGGCCCTGAGC
CCCTTGGAGGAGTGGCTTCGGCTGCACACCTACTTGGCCGGGGAGGCCCCCACTCTGGCT
GACCTGGCGGCTGTCACAGCCTTGCTGCTGCCTTTCCGATACGTCCTAGACCCACCTGCC
CGCCGGATCTGGAATAATGTGACTCGCTGGTTTGTCACGTGTGTCCGACAGCCAGAATTC
CGAGCCGTGCTAGGAGAAGTGGTTCTATACTCAGGAGCCAGGCCTCTCTCTCATCAGCCA
GGCCCCGAGGCTCCTGCCCTCCCAAAGACAGCTGCTCAGCTCAAGAAAGAGGCAAAGAAA
CGGGAGAAGCTAGAGAAATTCCAACAGAAGCAGAAGATCCAACAGCAGCAGCCACCTCCA
GGGGAGAAGAAACCAAAACCAGAGAAGAGGGAGAAACGGGATCCTGGGGTCATTACCTAT
GACCTCCCAACCCCACCCGGGGAAAAGAAAGATGTCAGTGGCCCCATGCCCGACTCCTAC
AGCCCTCGGTATGTGGAGGCTGCCTGGTACCCTTGGTGGGAGCAGCAGGGCTTCTTCAAG
CCAGAGTATGGGCGTCCTAATGTGTCAGCAGCAAATCCCCGAGGTGTCTTCATGATGTGC
ATCCCACCCCCCAATGTGACAGGCTCCCTGCACCTGGGCCATGCACTCACCAACGCCATC
CAGGACTCCCTGACTCGATGGCACCGCATGCGTGGGGAGACCACCCTGTGGAACCCTGGC
TGTGACCATGCAGGTATTGCCACCCAGGTGGTGGTGGAGAAGAAGCTATGGCGTGAGCAG
GGACTGAGCCGGCACCAGCTGGGCCGCGAGGCCTTTCTACAGGAAGTCTGGAAGTGGAAG
GAGGAGAAAGGTGACCGGATTTACCACCAGTTGAAGAAGCTTGGCAGCTCCTTGGACTGG
GATCGAGCCTGTTTCACCATGGACCCTAAACTCTCAGCAGCTGTGACAGAGGCCTTTGTC
CGGCTTCACGAGGAAGGCATCATCTATCGCAGTACCCGCCTTGTTAACTGGTCCTGCACC
CTCAACTCCGCCATCTCTGACATTGAGGTGGATAAGAAGGAGCTGACAGGTCGCACCCTG
CTCTCCGTGCCTGGCTACAAGGAGAAGGTGGAGTTCGGGGTCCTCGTGTCCTTTGCCTAT
AAGGTCCAAGGCTCAGATAGCGACGAGGAGGTGGTGGTGGCAACAACTCGGATCGAGACA
ATGCTGGGAGATGTGGCTGTAGCTGTGCACCCCAAAGATACCAGATACCAGCACCTGAAG
GGGAAGAACGTGATCCACCCATTCCTGTCTCGGAGCCTTCCCATTGTCTTCGATGAATTT
GTGGACATGGACTTTGGCACAGGTGCTGGGAAGATCACCCCCGCACATGACCAAAATGAC
TATGAAGTTGGGCAGCGGCACGGGCTGGAGGCCATCAGCATCATGGACTCCCGGGGGGGC
CCTCATCAATGTGCCTCCGCCTTTCCTGGGCCTGCCCAGGTTTTGAGGCCAGGAAAGCGG
TGCCTGGTGGCGCTGAAGGAGCGGGGACTGTTCCGTGGCATTGAGGACAACCCCATGGTG
GTGCCACTTTGCAACCGGTCGAAGGACGTGGTAGAGCCTCTGCTGCGGCCGCAGTGGTAC
GTTCGCTGCGGGGAGATGGCCCAGGCTGCCAGCGCCGCTGTGACTCGGGGTGACCTCCGC
ATCCTGCCTGAGGCCCATCAGCGCACATGGCATGCCTGGATGGACAACATCCGGGAGTGG
TGCATTTCCAGGCAGCTGTGGTGGGGCCATCGCATCCCAGCCTACTTTGTCACTGTCAGT
GACCCAGCGGTGCCCCCTGGGGAGGACCCTGATGGGCGGTACTGGGTGAGTGGACGCAAT
GAGGCGGAGGCCCGGGAGAAGGCAGCCAAGGAGTTCGGAGTGTCCCCTGACAAGATCAGT
CTCCAGCAAGATGAGGATGTATTGGATACCTGGTTCTTCTCTGGCCTCTTCCCCTTATCC
ATTTTGGGCTGGCCCAACCAGTCAGAAGACCTGAGTGTGTTCTACCCCGGGACACTGCTG
GAGACCGGTCATGACATCCTCTTCTTCTGGGTGGCCCGGATGGTCATGCTGGGCCTGAAG
CTCACGGGCAGGCTGCCCTTTAGAGAGGTCTACCTCCATGCCATCGTGCGAGATGCTCAC
GGCCGGAAGATGAGCAAGTCTCTAGGCAATGTCATCGATCCCCTGGACGTCATCTATGGA
ATCTCCCTGCAGGGCCTCCACAACCAGCTGCTGAACAGCAACCTGGATCCCAGCGAGGTG
GAGAAGGCCAAAGAAGGGCAGAAAGCTGACTTCCCAGCGGGGATTCCTGAATGTGGCACC
GATGCTCTCCGGTTTGGATTATGTGCCTACATGTCCCAGGGTCGTGACATCAACCTGGAT
GTGAACCGGATACTGGGTTACCGCCACTTCTGCAACAAGCTCTGGAATGCCACCAAGTTT
GCCCTTCGTGGCCTTGGGAAGGGTTTTGTGCCCTCACCCACCTCCCAGCCCGGAGGCCAT
GAGAGCCTGGTGGACCGCTGGATCCGCAGCCGCCTGACAGAGGCTGTGAGGCTCAGCAAT
CAAGGCTTCCAGGCCTACGACTTCCCGGCCGTCACCACTGCCCAGTACAGCTTCTGGCTC
TATGAGCTCTGTGATGTCTACTTGGAGTGCCTGAAACCTGTACTGAATGGGGTGGACCAG
GTGGCAGCTGAGTGTGCCCGCCAGACCCTGTACACTTGCCTGGACGTTGGCCTGCGGCTG
CTCTCACCCTTCATGCCCTTCGTGACGGAGGAGCTGTTCCAGAGGCTGCCCCGGAGGATG
CCGCAAGCTCCCCCTAGCCTCTGTGTTACCCCCTACCCGGAGCCCTCAGAGTGCTCCTGG
AAGGACCCCGAGGCAGAAGCCGCCCTTGAGCTGGCGCTAAGCATCACGCGAGCCGTGCGC
TCCCTGCGGGCCGACTACAACCTCACCCGGATCCGGCCTGACTGTTTCCTGGAAGTGGCG
GATGAGGCCACGGGCGCCCTGGCATCGGCGGTGTCGGGCTACGTGCAGGCCCTGGCCAGC
GCAGGTGTGGTGGCTGTTCTGGCCCTGGGGGCTCCCGCCCCCCAGGGTTGCGCTGTGGCT
CTGGCTTCTGATCGCTGCTCCATCCACCTGCAGCTTCAGGGGCTGGTGGACCCTGCACGG
GAGCTGGGCAAGCTGCAAGCCAAGCGAGTTGAGGCCCAGCGGCAGGCCCAGCGTCTGCGG
GAACGCCGTGCTGCCTCGGGCTATCCTGTCAAGGTGCCGCTCGAAGTCCAGGAGGCAGAT
GAAGCCAAGCTCCAACAGACAGAAGCAGAGCTCAGGAAGGTGGATGAGGCCATCGCCCTA
TTCCAGAAGATGCTGTGA

# Metabolic_Enzyme_112_GenBank_ID_Gene:
X59303

# Metabolic_Enzyme_112_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_112_Locus:
6p21.3

# Metabolic_Enzyme_112_SNPs:
Not Available

# Metabolic_Enzyme_112_General_References:
1898367; 14574404; 8428657

# Metabolic_Enzyme_112_References:
Not Available

# Metabolic_Enzyme_113_ID:
5924

# Metabolic_Enzyme_113_Name:
Adenylate kinase isoenzyme 5

# Metabolic_Enzyme_113_Synonyms:
ATP-AMP transphosphorylase

# Metabolic_Enzyme_113_Gene_Name:
AK5

# Metabolic_Enzyme_113_Protein_Sequence:
>Adenylate kinase isoenzyme 5
MGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLI
RDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVIC
MDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEG
TPEDVFLQLCTAIDSIIF

# Metabolic_Enzyme_113_Number_of_Residues:
198

# Metabolic_Enzyme_113_Molecular_Weight:
22088

# Metabolic_Enzyme_113_Theoretical_pI:
5.16

# Metabolic_Enzyme_113_GO_Classification:
>>>
Function:  phosphotransferase activity, phosphate group as acceptor
Function:  adenylate kinase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleotide kinase activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleoside triphosphate metabolism
Process:  purine ribonucleoside triphosphate metabolism
Process:  ATP metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_113_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_113_Specific_Function:
Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP

# Metabolic_Enzyme_113_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_113_Reaction:
ATP + AMP = 2 ADP

# Metabolic_Enzyme_113_Pfam_Domain_Function:
PF00406:ADK

# Metabolic_Enzyme_113_Signals:
None

# Metabolic_Enzyme_113_Transmembrane_Regions:
None

# Metabolic_Enzyme_113_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_113_EC_Link:
EC 2.7.4.3

# Metabolic_Enzyme_113_GenBank_ID_Protein:
4691541

# Metabolic_Enzyme_113_SwissProt_ID:
KAD5_HUMAN (Q9Y6K8)

# Metabolic_Enzyme_113_swissprot_Name:
Not Available

# Metabolic_Enzyme_113_Genecard_id:
AK5

# Metabolic_Enzyme_113_Geneatlas_id:
AK5

# Metabolic_Enzyme_113_hgnc_id:
HGNC:365

# Metabolic_Enzyme_113_PDB_ID:
Not Available

# Metabolic_Enzyme_113_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_113_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_113_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_113_Gene_Sequence:
>597 bp
ATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCT
GGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTC
TCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATC
AGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAG
GAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGG
GAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGT
ATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTG
CCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCC
ATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGA
ACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTATTTTCTGA

# Metabolic_Enzyme_113_GenBank_ID_Gene:
AF062595

# Metabolic_Enzyme_113_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_113_Locus:
1p31

# Metabolic_Enzyme_113_SNPs:
rs2803140; rs1167206; rs2815311; rs3509; rs10873950; rs2602946; rs4949811; rs2689680; rs6683829; rs10747353; rs1779173; rs7517796; rs2602945; rs1619903; rs4949788; rs12133976; rs6665543; rs6669724; rs2602944; rs7517698; rs7531431; rs2602943; rs6680763; rs3767031; rs4949660; rs7517717; rs3767030; rs7534033; rs11162308; rs2815313; rs2815324; rs1167214; rs1010195; rs1167202; rs2054020; rs1670617; rs2803152; rs2088518; rs1721163; rs2647486; rs1167205; rs2647497; rs1453982; rs2602936; rs2815319; rs1010196; rs1874817; rs2815325; rs2602934; rs1167201; rs1721165; rs1874819; rs2029768; rs1463324; rs2689683; rs1167212; rs1721166; rs936001; rs2602951; rs1909202; rs1377733; rs2647503; rs6672375; rs4949803; rs2251456; rs6696968; rs1874818; rs2803166; rs4949658; rs6681717; rs1377731; rs7547493; rs6680677; rs6675743; rs11808966; rs1721164; rs6603950; rs2815326; rs9324162; rs1498404; rs4949808; rs11162357; rs6667803; rs7545638; rs11162331; rs7514041; rs3911295; rs11162355; rs1167207; rs12564604; rs10873933; rs1823837; rs2815337; rs11162332; rs7517051; rs12049202; rs3844165; rs6684022; rs6658302; rs12079234; rs1993266; rs10873937; rs7524866; rs6663047; rs2803155; rs2803169; rs7514937; rs12044354; rs2054017; rs4949659; rs11162309; rs12040471; rs7537472; rs7518696; rs10873947; rs2815310; rs10493603; rs10873935; rs7545544; rs7512893; rs9324161; rs10782645; rs11162323; rs12567557; rs7531286; rs9787153; rs12565526; rs4949792; rs11162340; rs6662853; rs6691415; rs11162330; rs3844166; rs7546131; rs12079206; rs11162311; rs2647491; rs7522356; rs2647510; rs2815314; rs6696083; rs11162356; rs2247536; rs11810135; rs12074409; rs2034708; rs1532508; rs10747354; rs2803136; rs4949809; rs6704141; rs11162333; rs4949794; rs4245658; rs4033036; rs12076479; rs2803168; rs1616948; rs10782651; rs7515509; rs10782648; rs10873938; rs7537574; rs6703133; rs1823838; rs7542588; rs17100513; rs12142918; rs4351702; rs17100319; rs6668429; rs2351034; rs12130313; rs7534707; rs17100436; rs2689676; rs17100231; rs9633480; rs4949793; rs10873941; rs17100521; rs9633479; rs11162351; rs1779177; rs12136415; rs2349966; rs12568374; rs1498405; rs17100224; rs2647519; rs1670612; rs11806344; rs17100305; rs17100509; rs12132273; rs3767036; rs11584919; rs2815307; rs1603743; rs2799555; rs6673059; rs11162341; rs12125503; rs1167196; rs10493536; rs2882289; rs2198511; rs7546963; rs12140227; rs12093263; rs12141929; rs7514177; rs11583090; rs3112826; rs7529652; rs11585310; rs2803147; rs2799562; rs3896705; rs10518553; rs1498402; rs4949655; rs9439799; rs6695572; rs6603948; rs11162347; rs10873945; rs7512897; rs12568528; rs1616272; rs2647508; rs2133203; rs17379910; rs1377736; rs3112830; rs7551211; rs4600093; rs11162319; rs1453974; rs11806197; rs6695989; rs2349965; rs11162312; rs10518551; rs1532509; rs1565850; rs3738079; rs11588898; rs2815323; rs11162334; rs17100274; rs1874816; rs2647499; rs4033035; rs17098286; rs11585455; rs6698295; rs1167215; rs1670618; rs12069838; rs1377732; rs12030598; rs1167217; rs10493605; rs1377734; rs12095801; rs11162350; rs7549462; rs12037071; rs2256679; rs11590456; rs10493606; rs11809786; rs2799553; rs17380592; rs1869467; rs4949802; rs6667519; rs6661765; rs12407481; rs7521772; rs7536307; rs17100646; rs2799561; rs2247742; rs2602927; rs1670611; rs12564592; rs1565851; rs2246124; rs6702968; rs6697255; rs12724560; rs2803153; rs7536433; rs2172727; rs7537603; rs1840246; rs17100317; rs4033037; rs6685087; rs12404204; rs6675781; rs12070870; rs6689581; rs10782647; rs3911801; rs12568376; rs7531411; rs17380852; rs17100308; rs1551331; rs12569104; rs5018314; rs1353727; rs3767033; rs4949800; rs4949799; rs12124822; rs17380036; rs10493602; rs10873934; rs11162352; rs10873944; rs1779178; rs3767035; rs4949654; rs9324160; rs1498400; rs17100499; rs17098287; rs7536818; rs11162326; rs2602948; rs2602953; rs12022440; rs9787060; rs12123060; rs4949789; rs3896706; rs17100674; rs1498403; rs17380796; rs7528932; rs6659899; rs17100570; rs10782646; rs10493604; rs12402184; rs6703688; rs1498399; rs17100524; rs2133204; rs3767032; rs12760589; rs12079316; rs6687876; rs7554922; rs3121778; rs12030302; rs11162336; rs12565558; rs11583735; rs11807111; rs12079185; rs17100458; rs17378915; rs2245189; rs7519901; rs11800652; rs1498401; rs7367731; rs17384946; rs2647515; rs6603949; rs1498407; rs4491097; rs11162310; rs12062661; rs2602937; rs12080101; rs3767034; rs1869468; rs17100204; rs12071212; rs17100218; rs11162335; rs2647525; rs17100475; rs12133318; rs17098226; rs1167216; rs17380544; rs10735750; rs12030818; rs7516637; rs11162364; rs936004; rs12068040; rs1823840; rs11162324; rs17100654; rs2602932; rs6704312; rs12754926; rs6603951; rs1353726; rs7517486; rs1869466; rs2803144; rs2803164; rs4949798; rs12048207; rs7537639; rs12031867; rs10873936; rs17100731; rs4431892; rs12073309; rs12128049; rs2689684; rs12733666; rs11162348; rs2803149; rs3962875; rs1167200; rs7532748; rs4949656; rs4949791; rs12131772; rs12726963; rs6674790; rs17100672; rs2349964; rs2647523; rs11162362; rs2799550; rs2647487; rs17100422; rs12404374; rs7527150; rs12073962; rs6680888; rs2647517; rs1779175; rs3862893; rs12741939; rs2815335; rs6680716; rs11162339; rs7516300; rs4949807; rs10127564; rs2054019; rs17100172; rs17100677; rs11590086; rs2602940; rs12144794; rs1377737; rs7551729; rs12066994; rs17100185; rs12736701; rs1532511; rs17100655; rs9439800; rs10782654; rs12730089; rs2602942; rs6603940; rs12060669; rs3113637; rs12037848; rs11162327; rs2815305; rs7415865; rs2799554; rs12092582; rs2647512; rs7529083; rs2803139; rs4949797; rs2803162; rs6673604; rs12404342; rs1167198; rs2647522; rs11162337; rs2647484; rs12740982; rs2803157; rs11811611; rs7519476; rs7546116; rs12401953; rs12034899; rs1615404; rs2351032; rs4949805; rs2256735; rs1670616; rs17380099; rs1167209; rs7550626; rs2647520; rs12045755; rs11585860; rs2803160; rs1721167; rs2815309; rs4589153; rs4949653; rs2123799; rs1167213; rs6603943; rs2602949; rs2647514; rs1909203; rs12080110; rs4245657; rs11162363; rs11162329; rs7524147; rs10873949; rs12033923; rs12409322; rs12062754; rs11162358; rs2351033; rs12070567; rs2815331; rs12047928; rs1010061; rs9633478; rs2647504; rs17100377; rs7532803; rs17100440; rs6603941; rs11162342; rs17100692; rs2647493; rs2133202; rs7512141; rs1966873; rs12730972; rs17100476; rs2221084; rs2647498; rs12046197; rs17385141; rs12135843; rs2647526; rs17100241; rs12077615; rs12567785; rs2799551; rs17100198; rs17100556; rs12065923; rs4402168; rs12093881; rs1532507; rs12731886; rs17379082; rs2602931; rs2647516; rs3104461; rs2815317; rs2815306; rs17100694; rs11162317; rs6694630; rs13376422; rs2815327; rs17371324; rs10873939; rs2154090; rs6603952; rs10873942; rs4949790; rs17100478; rs17100364; rs12745549; rs17100425; rs12085340; rs12122210; rs1167210; rs6603953; rs1377738; rs17100530; rs17100456; rs7545096; rs12751064; rs12042177; rs2815320; rs12097089; rs12030606; rs2803163; rs1909204; rs11583934; rs2803156; rs2054018; rs2647494; rs1670609; rs2647521; rs3104467; rs2815334; rs1976334; rs10873930; rs2996486; rs17100463; rs2799563; rs6671137; rs6698996; rs2167994; rs1377735; rs1779181; rs7546409; rs4949806; rs11162338; rs2799552; rs11162313; rs1670605; rs2803148; rs12729914; rs12404245; rs2602941; rs12751884; rs10873946; rs7543460; rs11162318; rs2803161; rs12095064; rs1453981; rs11162325; rs2647496; rs2647485; rs2647513; rs2815312; rs12031094; rs17100429; rs6692369; rs1167204; rs17695152; rs17100304; rs2647506; rs1167197; rs10873932; rs2799560; rs2803150; rs1013399; rs6693999; rs7528552; rs4949804; rs7511768; rs1851736; rs2004962; rs2799568; rs6697938; rs12126361; rs3835545; rs12028798; rs41292256; rs35474678; rs35528982; rs10577779; rs34360007; rs28476720; rs3835546; rs28605112; rs12184282; rs34108682; rs2647490; rs34641015; rs41292264; rs5775404; rs35194423; rs3077577; rs28701620; rs34309381; rs5775392; rs4539179; rs3113636; rs3032910; rs5024339; rs34342162; rs10618389; rs35528361; rs12239674; rs34939965; rs6699414; rs35045554; rs34509475; rs12752648; rs12747320; rs2803171; rs10610715; rs12737543; rs12753797; rs10643921; rs34198954; rs35490046; rs4491099; rs4567326; rs2133205; rs2803146; rs33950044; rs2803137; rs36066707; rs41292268; rs34561659; rs12747609; rs12130867; rs34444999; rs10581719; rs5775400; rs35473006; rs34632021; rs35962579; rs34563024; rs28482266; rs1670614; rs35364802; rs34520920; rs11585233; rs34026852; rs34899933; rs34781584; rs34093068; rs11351073; rs2799558; rs35905985; rs3112828; rs36121999; rs11275907; rs5775406; rs35340213; rs12089562; rs1470898; rs34216425; rs35100611; rs6603942; rs2647492; rs12737982; rs3113639; rs35597576; rs6660312; rs34812657; rs5775394; rs3911296; rs11306378; rs12754946; rs5775386; rs12741407; rs6659799; rs6663792; rs34544896; rs35047787; rs10672519; rs34500185; rs35425557; rs34578405; rs11384873; rs11331001; rs2647502; rs41292266; rs34019719; rs2815328; rs12754430; rs34579463; rs4033046; rs2882564; rs4033034; rs1779180; rs12738950; rs12089711; rs35137146; rs34732222; rs1973057; rs35367032; rs34776258; rs4546964; rs3892546; rs1936437; rs3122396; rs2803154; rs35752791; rs11310843; rs34997978; rs11162328; rs10658959; rs5775396; rs1840247; rs34814131; rs34219620; rs41306633; rs9439784; rs34229344; rs12065811; rs34800536; rs12760955; rs10641799; rs12742485; rs4949801; rs5775408; rs35923030; rs35263113; rs2647488; rs1453975; rs12088702; rs7417258; rs1532510; rs3077617; rs11585641; rs34191126; rs3104462; rs12025030; rs35881426; rs2647524; rs5775388; rs35160863; rs34079169; rs3104466; rs6700151; rs2454328; rs11583478; rs12731521; rs34781573; rs28635212; rs1721168; rs12129136; rs11355323; rs35670415; rs35883964; rs41428048; rs17381128; rs12145231; rs6664497; rs5775409; rs3913229; rs12095237; rs4420134; rs28858546; rs35866723; rs34676920; rs2602929; rs36053089; rs35157453; rs34570834; rs2803142; rs28560013; rs11287373; rs5775390; rs34854145; rs2256812; rs12039708; rs35838303; rs4562674; rs6660313; rs35754175; rs1498409; rs7532905; rs1167211; rs3100632; rs11583481; rs12240043; rs35205007; rs12137455; rs17100210; rs34162977; rs35651270; rs35751413; rs10687945; rs34192042; rs34581049; rs721514; rs4317858; rs12741389; rs4033042; rs3104464; rs3121777; rs12753082; rs34374541; rs12059542; rs34624933; rs4342893; rs2803167; rs35029067; rs12079001; rs10635433; rs35612924; rs36055551; rs6670567; rs12732540; rs36024544; rs34721376; rs17100430; rs1779176; rs2803135; rs12034210; rs2647505; rs11387882; rs35916064; rs2018388; rs34276249; rs12406551; rs11162345; rs34517694; rs12731983; rs12024819; rs6657424; rs11577058; rs2602939; rs11455000; rs28878211; rs11356289; rs11585642; rs1779179; rs5775398; rs10873948; rs33942843; rs1179473; rs6668328; rs34038217; rs35032414; rs10651968; rs12746354; rs4604738; rs10589201; rs11428852; rs34783496; rs12140779; rs7411262; rs35038885; rs10625327; rs12563604; rs12743457; rs12022986; rs12732561; rs34335914; rs34567357; rs34828972; rs35304863; rs35393140; rs35973848; rs11290615; rs35239700; rs1167203; rs2799556; rs35844658; rs12756901; rs28823938; rs34391713; rs10673675; rs28608963; rs12133202; rs12071077; rs28541326; rs28395330; rs12035195; rs2803159; rs5775399; rs2803138; rs11411925; rs12757491; rs34996477; rs7520851; rs11305805; rs28890262; rs10873940; rs3112829; rs2803143; rs10700476; rs35298406; rs6699130; rs34919195; rs2799559; rs3100631; rs1453976; rs35412216; rs34463378; rs10568838; rs3104463; rs34277277; rs12057706; rs12735196; rs2088517; rs34167936; rs34565581; rs5775393; rs34710967; rs4033040; rs36008355; rs34131257; rs12070404; rs2803165; rs34141642; rs12046067; rs35729964; rs7416803; rs33994249; rs35251829; rs12068504; rs7549417; rs34395455; rs4949657; rs35480521; rs34496684; rs4351701; rs12135900; rs5775383; rs2647501; rs1936438; rs7417209; rs35272247; rs4556409; rs1498408; rs3851266; rs10586398; rs12731121; rs7417056; rs6700681; rs3077570; rs34667944; rs35282414; rs7411526; rs12043793; rs34360551; rs6670430; rs35772583; rs12126330; rs17381238; rs35427612; rs34979299; rs5775397; rs9439819; rs1177502; rs7546981; rs12137672; rs11162361; rs9661264; rs5775407; rs2647489; rs1183243; rs34506812; rs34623145; rs35352712; rs12172739; rs12404451; rs34996626; rs12132133; rs12034334; rs3921995; rs3077541; rs34619075; rs35087048; rs34407415; rs2815333; rs34865607; rs1823839; rs12756133; rs28483962; rs2647518; rs12041666; rs12737014; rs5775387; rs11380102; rs12753538; rs4033045; rs34103321; rs36089522; rs34975081; rs10712325; rs34855794; rs5024338; rs2602933; rs36075033; rs34140909; rs35254623; rs12125923; rs34652234; rs10587637; rs2647495; rs34326091; rs34568620; rs36051497; rs34404890; rs2123796; rs36083236; rs2803170; rs5775395; rs2803151; rs6664913; rs12752918; rs11324649; rs35305856; rs35569847; rs12738273; rs12072100; rs1670610; rs10526328; rs34679101; rs12088013; rs12139240; rs11162346; rs12748599; rs34775316; rs34657715; rs35836390; rs12568051; rs12042881; rs34907598; rs12732787; rs2803141; rs2815329; rs34425821; rs41292260; rs35060423; rs35692250; rs11364704; rs35126601; rs11350511; rs35709353; rs12566093; rs3862894; rs28631005; rs34206262; rs10547281; rs10637505; rs35587548; rs35216620; rs12144818; rs36098400; rs5775382; rs33980298; rs35783103; rs12728752; rs36087243; rs28644426; rs28369006; rs3112825; rs3113640; rs12742953; rs35463751; rs12737366; rs12041509; rs35548350; rs34365360; rs12036958; rs34291857; rs1670615; rs36057604; rs35886747; rs33929714; rs12062613; rs35328311; rs35478846; rs34396257; rs35475576; rs2088519; rs7410994; rs34155195; rs2602938; rs11162344; rs36116132; rs34186386; rs7524107; rs3122366; rs10625085; rs35690647; rs34506775; rs2815336; rs36099665; rs36120231; rs12735922; rs35335455; rs12061595; rs3113638; rs12125332; rs34783278; rs34235538; rs34221500; rs35740273; rs2123798; rs3112827; rs12069995; rs35413139; rs11440245; rs1167208; rs35185203; rs3104465; rs34818192; rs17100630; rs4638175; rs17100538; rs12078902; rs41292262; rs2647507; rs2799557; rs5775391; rs35635429; rs35462161; rs1167199; rs5775403; rs12097728; rs5775389; rs28776274; rs2454329; rs2803158; rs34422174; rs11347735; rs12747284; rs10700619; rs35500871; rs41301251; rs12239270; rs4033041; rs10524122; rs11345707; rs34298832; rs35111545; rs7416385; rs34178467; rs12130891; rs34646507; rs12030935; rs12094209; rs7413421; rs2602928; rs10647386; rs1670613; rs34698864; rs2351031; rs1869469; rs2029769; rs12066590; rs34451301; rs35009400; rs12030994; rs12136831; rs6685119; rs35260482; rs11807469; rs12135530; rs35930501; rs35487420; rs1851735; rs11580677; rs35371663; rs2272161; rs34538335; rs1027354; rs10493537; rs10493601; rs10518446; rs10735749; rs11162306; rs11162307; rs11162365; rs12062309; rs12065011; rs12076331; rs12126117; rs12132703; rs12142405; rs12759796; rs13806; rs1419247; rs17100141; rs17100143; rs17100758; rs1721160; rs17385707; rs17689089; rs1962523; rs2220835; rs2291689; rs2291690; rs2602930; rs2647511; rs35055337; rs35740293; rs4949787; rs4949812; rs4949813; rs6656443; rs6678173; rs6692366; rs728741; rs7552291

# Metabolic_Enzyme_113_General_References:
10215863

# Metabolic_Enzyme_113_References:
Not Available

# Metabolic_Enzyme_114_ID:
5925

# Metabolic_Enzyme_114_Name:
Selenide, water dikinase 1

# Metabolic_Enzyme_114_Synonyms:
Selenophosphate synthetase 1; Selenium donor protein 1

# Metabolic_Enzyme_114_Gene_Name:
SEPHS1

# Metabolic_Enzyme_114_Protein_Sequence:
>Selenide, water dikinase 1
MSTRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAV
MPRLGIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECD
NMLMLLGVSNKMTDRERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVC
QPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWLDIPEKWNKIKLVVTQEDVELAYQEA
MMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMA
AVSKACGNMFGLMHGTCPETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKG
NRTARIIDKPRIIEVAPQVATQNVNPTPGATS

# Metabolic_Enzyme_114_Number_of_Residues:
392

# Metabolic_Enzyme_114_Molecular_Weight:
42911

# Metabolic_Enzyme_114_Theoretical_pI:
5.84

# Metabolic_Enzyme_114_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  selenide, water dikinase activity
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_114_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_114_Specific_Function:
Synthesizes selenophosphate from selenide and ATP

# Metabolic_Enzyme_114_Pathway:
map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_114_Reaction:
ATP + selenide + H2O = AMP + selenophosphate + phosphate

# Metabolic_Enzyme_114_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C

# Metabolic_Enzyme_114_Signals:
None

# Metabolic_Enzyme_114_Transmembrane_Regions:
None

# Metabolic_Enzyme_114_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_114_EC_Link:
EC 2.7.9.3

# Metabolic_Enzyme_114_GenBank_ID_Protein:
1000284

# Metabolic_Enzyme_114_SwissProt_ID:
SPS1_HUMAN (P49903)

# Metabolic_Enzyme_114_swissprot_Name:
Not Available

# Metabolic_Enzyme_114_Genecard_id:
SEPHS1

# Metabolic_Enzyme_114_Geneatlas_id:
SEPHS1

# Metabolic_Enzyme_114_hgnc_id:
HGNC:19685

# Metabolic_Enzyme_114_PDB_ID:
Not Available

# Metabolic_Enzyme_114_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_114_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_114_Subcellular_Location:
Not Available

# Metabolic_Enzyme_114_Gene_Sequence:
>1152 bp
ATGTCTACGCGGGAGTCCTTTAACCCGGAAAGTTACGAATTGGACAAAAGCTTCCGGCTA
ACCAGATTCACTGAACTGAAGGGCACAGGCTGCAAAGTGCCCCAAGATGTCCTGCAAAAA
TTGCTGGAATCTTTACAGGAGAACCACTTCCAAGAAGATGAGCAGTTTCTGGGAGCCGTT
ATGCCAAGGCTTGGCATTGGAATGGATACTTGTGTCATTCCTTTGAGGCACGGTGGGCTT
TCCTTGGTTCAAACCACAGATTACATTTACCCGATCGTAGACGACCCTTACATGATGGGC
AGGATAGCGTGTGCCAATGTCCTCAGTGACCTCTATGCAATGGGGGTCACGGAATGTGAC
AATATGCTGATGCTCCTTGGAGTCAGTAATAAAATGACCGACAGGGAAAGGGATAAAGTG
ATGCCTCTGATTATCCAAGGTTTTAAAGACGCAGCTGAGGAAGCAGGAACGTCTGTAACA
GGCGGCCAAACAGTACTAAACCCCTGGATTGTCCTGGGAGGAGTGGCTACCACTGTCTGC
CAACCCAATGAATTTATCATGCCAGACAATGCAGTGCCAGGGGACGTGCTGGTGCTGACA
AAACCCCTGGGGACACAGGTGGCAGTGGCTGTGCACCAGTGGCTGGATATCCCTGAGAAA
TGGAATAAGATTAAACTAGTGGTCACCCAAGAAGATGTAGAGCTGGCCTACCAGGAGGCG
ATGATGAACATGGCGAGGCTCAACAGGACAGCTGCAGGACTCATGCACACGTTCAATACC
CACGCCGCCACTGACATCACGGGCTTCGGGATTTTGGGCCATGCGCAGAACCTGGCCAAG
CAGCAGAGGAACGAGGTGTCGTTTGTAATTCACAACCTCCCGGTGCTGGCCAAGATGGCT
GCGGTGAGCAAGGCCTGCGGAAACATGTTCGGCCTCATGCACGGGACCTGCCCGGAGACT
TCAGGCGGCCTTCTGATCTGTTTACCACGTGAGCAAGCAGCTCGGTTCTGTGCAGAGATA
AAGTCCCCCAAATATGGTGAAGGCCACCAAGCATGGATTATTGGGATTGTAGAGAAGGGC
AACCGCACAGCCAGAATCATAGACAAACCCCGGATCATCGAGGTCGCACACAAGTGGCCA
CTCAAAACGTGA

# Metabolic_Enzyme_114_GenBank_ID_Gene:
U34044

# Metabolic_Enzyme_114_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_114_Locus:
10p14

# Metabolic_Enzyme_114_SNPs:
rs10752297; rs2275127; rs1005089; rs10752299; rs1556717; rs1004621; rs12569988; rs2254252; rs1747683; rs10508459; rs647253; rs2275129; rs10796060; rs10752296; rs7095230; rs2254154; rs7901303; rs7897851; rs2275128; rs3781087; rs2027167; rs7914142; rs10906347; rs10752294; rs1983830; rs10737069; rs3824655; rs6602648; rs10737070; rs2181839; rs17153117; rs3802584; rs7475361; rs10752298; rs4750346; rs1414399; rs10906348; rs3802583; rs7901525; rs11814895; rs11818582; rs7919509; rs17153110; rs2254157; rs7903477; rs3802582; rs11258334; rs10796059; rs9664303; rs17153104; rs7082928; rs3802585; rs10906352; rs10752295; rs10128408; rs10906353; rs11258325; rs3740211; rs7917549; rs584285; rs3781085; rs10906350; rs7918050; rs7894075; rs10796062; rs7916194; rs10906349; rs11595473; rs7100588; rs10737068; rs1547772; rs10796065; rs17153099; rs563564; rs2783648; rs11258324; rs1802843; rs7898477; rs28711667; rs7902331; rs2650; rs28649208; rs28410783; rs28422123; rs7901957; rs34626058; rs28451457; rs3864819; rs28756245; rs28670344; rs28682928; rs7901671; rs35862415; rs36108296; rs34242277; rs36072408; rs35387458; rs41291321; rs34648460; rs4475828; rs3215961; rs3802581; rs34658221; rs35446292; rs4278421; rs11816087; rs34027603; rs34774726; rs36025626; rs11258328; rs11258330; rs35535987; rs10552528; rs41291319; rs34933494; rs11258327; rs10546800; rs35582737; rs11258335; rs2001263; rs12247089; rs7902435; rs34946567; rs7919016; rs11818504; rs11258331; rs4474338; rs7083997; rs11258332; rs2265012; rs34250326; rs12265313; rs35635684; rs34167659; rs11258326; rs11591432; rs7095440; rs35840117; rs35374518; rs12255910; rs10128117; rs11258333; rs34788028; rs3802580; rs11258329; rs41302978; rs11345855; rs11442459; rs2253619; rs2253617; rs28742249; rs28468083; rs35249604; rs11430962; rs7088002; rs34467541; rs10752293; rs10796058; rs10906354; rs10906357; rs1095367; rs1095368; rs11258322; rs11258337; rs12765578; rs17529609; rs17602403; rs615497; rs7907912; rs7915089; rs7923713

# Metabolic_Enzyme_114_General_References:
7665581

# Metabolic_Enzyme_114_References:
Not Available

# Metabolic_Enzyme_115_ID:
5926

# Metabolic_Enzyme_115_Name:
Ubiquitin-conjugating enzyme E2 N

# Metabolic_Enzyme_115_Synonyms:
Ubiquitin-protein ligase N; Ubiquitin carrier protein N; Ubc13; Bendless-like ubiquitin-conjugating enzyme

# Metabolic_Enzyme_115_Gene_Name:
UBE2N

# Metabolic_Enzyme_115_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 
NMAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLP
EEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDD
PLANDVAEQWKTNEAQAIETARAWTRLYAMNNI

# Metabolic_Enzyme_115_Number_of_Residues:
152

# Metabolic_Enzyme_115_Molecular_Weight:
17138

# Metabolic_Enzyme_115_Theoretical_pI:
6.53

# Metabolic_Enzyme_115_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_115_General_Function:
Not Available

# Metabolic_Enzyme_115_Specific_Function:
The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys- 63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligase SHPRH in the poly- ubiquitination of PCNA 'Lys-164' upon genotoxic stress, which is required for DNA repair

# Metabolic_Enzyme_115_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_115_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_115_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_115_Signals:
None

# Metabolic_Enzyme_115_Transmembrane_Regions:
None

# Metabolic_Enzyme_115_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_115_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_115_GenBank_ID_Protein:
1181558

# Metabolic_Enzyme_115_SwissProt_ID:
UBE2N_HUMAN (P61088)

# Metabolic_Enzyme_115_swissprot_Name:
Not Available

# Metabolic_Enzyme_115_Genecard_id:
UBE2N

# Metabolic_Enzyme_115_Geneatlas_id:
UBE2N

# Metabolic_Enzyme_115_hgnc_id:
HGNC:12492

# Metabolic_Enzyme_115_PDB_ID:
1J7D

# Metabolic_Enzyme_115_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_115_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_115_Subcellular_Location:
Not Available

# Metabolic_Enzyme_115_Gene_Sequence:
>459 bp
ATGGCCGGGCTGCCCCGCAGGATCATCAAGGAAACCCAGCGTTTGCTGGCAGAACCAGTT
CCTGGCATCAAAGCCGAACCAGATGAGAGCAACGCCCGTTATTTTCATGTGGTCATTGCT
GGCCCTCAGGATTCCCCCTTTGAGGGAGGGACTTTTAAACTTGAACTATTCCTTCCAGAA
GAATACCCAATGGCAGCCCCTAAAGTACGTTTCATGACCAAAATTTATCATCCTAATGTA
GACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATAAGTGGTCCCCAGCACTGCAG
ATCCGCACAGTTCTGCTATCGATCCAGGCCTTGTTAAGTGCTCCCAATCCAGATGATCCA
TTAGCAAATGATGTAGCGGAGCAGTGGAAGACCAACGAAGCCCAAGCCATAGAAACAGCT
AGAGCATGGACTAGGCTATATGCCATGAATAATATTTAA

# Metabolic_Enzyme_115_GenBank_ID_Gene:
D83004

# Metabolic_Enzyme_115_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_115_Locus:
12q22

# Metabolic_Enzyme_115_SNPs:
rs643247; rs1021136; rs7484825; rs7953247; rs12426990; rs7484824; rs7303325; rs7305670; rs7300607; rs7303274; rs7311222; rs11107025; rs11831401; rs17021218; rs17021226; rs17021223; rs17021220; rs1483003; rs2291266; rs4020454; rs7969431; rs7305153; rs17251787; rs12303259; rs11835441; rs11107020; rs7299705; rs11107024; rs7295796; rs11107018; rs4020453; rs12830302; rs6538418; rs17021224; rs7309933; rs12810300; rs11107022; rs11107017; rs7953721; rs12816436; rs7968453; rs3759169; rs3952508; rs7956793; rs12311641; rs11558876; rs13633; rs643258; rs35415779; rs11558877; rs34880795; rs11107016; rs11558873; rs574299; rs11558878; rs643636; rs11558874; rs34704075; rs11107021; rs34053448; rs641414; rs11833560; rs35091571; rs563966; rs7295360; rs607605; rs34525749; rs3782416; rs10437876; rs506911; rs531209; rs11107027; rs11835400; rs17021222; rs563933; rs607963; rs471862; rs35846559; rs664063; rs11107029; rs11835514; rs558419; rs35125903; rs657971; rs524497; rs35555714; rs4020452; rs563965; rs28641961; rs7303001; rs10459181; rs11107026; rs34720175; rs36018210; rs34530254; rs494999; rs7314146; rs35048677; rs34318510; rs11107028; rs35569740; rs35124423; rs3049603; rs11107023; rs524498; rs12809242; rs35343851; rs34065836; rs12821477; rs12312856; rs853669; rs10459180; rs10714261; rs34757750; rs12826404; rs1845371; rs596795; rs7132349; rs486398; rs35730071; rs7957305; rs7972279; rs12821933; rs34934936; rs7342330; rs12822459; rs12318501; rs12821957; rs7484994; rs535319; rs35097702; rs10859492; rs12597; rs12819043; rs35288079; rs668294; rs7306955; rs7962893; rs7973701; rs7973789

# Metabolic_Enzyme_115_General_References:
8902611; 10089880

# Metabolic_Enzyme_115_References:
Not Available

# Metabolic_Enzyme_116_ID:
5927

# Metabolic_Enzyme_116_Name:
cGMP-specific 3',5'-cyclic phosphodiesterase

# Metabolic_Enzyme_116_Synonyms:
CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase

# Metabolic_Enzyme_116_Gene_Name:
PDE5A

# Metabolic_Enzyme_116_Protein_Sequence:
>cGMPspecific 3',5'cyclic phosphodiesterase
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSVPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN

# Metabolic_Enzyme_116_Number_of_Residues:
875

# Metabolic_Enzyme_116_Molecular_Weight:
100014

# Metabolic_Enzyme_116_Theoretical_pI:
6.00

# Metabolic_Enzyme_116_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric diester hydrolase activity
Function:  cyclic-nucleotide phosphodiesterase activity
Function:  3',5'-cyclic-nucleotide phosphodiesterase activity
Function:  catalytic activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_116_General_Function:
Not Available

# Metabolic_Enzyme_116_Specific_Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP

# Metabolic_Enzyme_116_Pathway:
Not Available

# Metabolic_Enzyme_116_Reaction:
guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate

# Metabolic_Enzyme_116_Pfam_Domain_Function:
PF01590:GAF;
PF00233:PDEase_I

# Metabolic_Enzyme_116_Signals:
None

# Metabolic_Enzyme_116_Transmembrane_Regions:
None

# Metabolic_Enzyme_116_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_116_EC_Link:
EC 3.1.4.35

# Metabolic_Enzyme_116_GenBank_ID_Protein:
3420185

# Metabolic_Enzyme_116_SwissProt_ID:
PDE5A_HUMAN (O76074)

# Metabolic_Enzyme_116_swissprot_Name:
Not Available

# Metabolic_Enzyme_116_Genecard_id:
PDE5A

# Metabolic_Enzyme_116_Geneatlas_id:
PDE5A

# Metabolic_Enzyme_116_hgnc_id:
HGNC:8784

# Metabolic_Enzyme_116_PDB_ID:
Not Available

# Metabolic_Enzyme_116_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_116_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_116_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_116_Gene_Sequence:
>2628 bp
ATGGAGCGGGCCGGCCCCAGCTTCGGGCAGCAGCGACAGCAGCAGCAGCCCCAGCAGCAG
AAGCAGCAGCAGAGGGATCAGGACTCGGTCGAAGCATGGCTGGACGATCACTGGGACTTT
ACCTTCTCATACTTTGTTAGAAAAGCCACCAGAGAAATGGTCAATGCATGGTTTGCTGAG
AGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCT
TGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGTCCCTGGAACACCAACCAGGAAA
ATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGA
ACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGG
TTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCT
AGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATA
TCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTT
ATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGT
ATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTG
AACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGC
TACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAATCATAGGGAAGAGGTTGTTGGT
GTAGCCCAGGCCATCAACAAGAAATCAGGAAACGGTGGGACATTTACTGAAAAAGATGAA
AAGGACTTTGCTGCTTATTTGGCATTTTGTGGTATTGTTCTTCATAATGCTCAGCTCTAT
GAGACTTCACTGCTGGAGAACAAGAGAAATCAGGTGCTGCTTGACCTTGCTAGTTTAATT
TTTGAAGAACAACAATCATTAGAAGTAATTTTGAAGAAAATAGCTGCCACTATTATCTCT
TTCATGCAAGTGCAGAAATGCACCATTTTCATAGTGGATGAAGATTGCTCCGATTCTTTT
TCTAGTGTGTTTCACATGGAGTGTGAGGAATTAGAAAAATCATCTGATACATTAACAAGG
GAACATGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAATACTATGGAA
CCACTTAATATCCCAGATGTCAGTAAGGATAAAAGATTTCCCTGGACAACTGAAAATACA
GGAAATGTAAACCAGCAGTGCATTAGAAGTTTGCTTTGTACACCTATAAAAAATGGAAAG
AAGAATAAAGTTATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAATACTGGCAAG
GTTAAGCCTTTCAACCGAAATGACGAACAGTTTCTGGAAGCTTTTGTCATCTTTTGTGGC
TTGGGGATCCAGAACACGCAGATGTATGAAGCAGTGGAGAGAGCCATGGCCAAGCAAATG
GTCACATTGGAGGTTCTGTCGTATCATGCTTCAGCAGCAGAGGAAGAAACAAGAGAGCTA
CAGTCGTTAGCGGCTGCTGTGGTGCCATCTGCCCAGACCCTTAAAATTACTGACTTTAGC
TTCAGTGACTTTGAGCTGTCTGATCTGGAAACAGCACTGTGTACAATTCGGATGTTTACT
GACCTCAACCTTGTGCAGAACTTCCAGATGAAACATGAGGTTCTTTGCAGATGGATTTTA
AGTGTTAAGAAGAATTATCGGAAGAATGTTGCCTATCATAATTGGAGACATGCCTTTAAT
ACAGCTCAGTGCATGTTTGCTGCTCTAAAAGCAGGCAAAATTCAGAACAAGCTGACTGAC
CTGGAGATACTTGCATTGCTGATTGCTGCACTAAGCCACGATTTGGATCACCGTGGTGTG
AATAACTCTTACATACAGCGAAGTGAACATCCACTTGCCCAGCTTTACTGCCATTCAATC
ATGGAACACCATCATTTTGACCAGTGCCTGATGATTCTTAATAGTCCAGGCAATCAGATT
CTCAGTGGCCTCTCCATTGAAGAATATAAGACCACGTTGAAAATAATCAAGCAAGCTATT
TTAGCTACAGACCTAGCACTGTACATTAAGAGGCGAGGAGAATTTTTTGAACTTATAAGA
AAAAATCAATTCAATTTGGAAGATCCTCATCAAAAGGAGTTGTTTTTGGCAATGCTGATG
ACAGCTTGTGATCTTTCTGCAATTACAAAACCCTGGCCTATTCAACAACGGATAGCAGAA
CTTGTAGCAACTGAATTTTTTGATCAAGGAGACAGAGAGAGAAAAGAACTCAACATAGAA
CCCACTGATCTAATGAACAGGGAGAAGAAAAACAAAATCCCAAGTATGCAAGTTGGGTTC
ATAGATGCCATCTGCTTGCAACTGTATGAGGCCCTGACCCACGTGTCAGAGGACTGTTTC
CCTTTGCTAGATGGCTGCAGAAAGAACAGGCAGAAATGGCAGGCCCTTGCAGAACAGCAG
GAGAAGATGCTGATTAATGGGGAAAGCGGCCAGGCCAAGCGGAACTGA

# Metabolic_Enzyme_116_GenBank_ID_Gene:
AF043731

# Metabolic_Enzyme_116_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_116_Locus:
4q25-q27

# Metabolic_Enzyme_116_SNPs:
rs3733526; rs17051276; rs11947234; rs6817975; rs4834789; rs10022664; rs4834790; rs4833622; rs6847164; rs17006190; rs7672961; rs6817738; rs10050092; rs4834788; rs6839165; rs4597811; rs11734241; rs6534146; rs11729521; rs11731568; rs13124532; rs4287988; rs2953294; rs6534145; rs2953293; rs3109370; rs12505735; rs4626181; rs6534147; rs1480938; rs28578366; rs12502511; rs11730798; rs6855918; rs6832740; rs17355550; rs8180147; rs28681016; rs7681796; rs6831062; rs1045177; rs2953290; rs4833620; rs2953295; rs2389885; rs4833621; rs17006236; rs7693919; rs7672519; rs6534148; rs13106925; rs28535956; rs1010740; rs2715021; rs2291185; rs1480939; rs2715018; rs1987179; rs1552095; rs1480940; rs1155576; rs1383532; rs2306456; rs2389869; rs1010739; rs3736115; rs7687843; rs7688802; rs2389866; rs3733523; rs11731756; rs11098531; rs12502423; rs11736416; rs12510138; rs12498599; rs11098532; rs3775844; rs3756157; rs7699064; rs2248236; rs12642735; rs13107334; rs3775847; rs12502389; rs2127822; rs3775854; rs9997631; rs10030660; rs3775852; rs12646525; rs2256645; rs1383533; rs10009626; rs7694856; rs2622499; rs2622500; rs10008791; rs4834779; rs1480933; rs13128602; rs3775845; rs6534140; rs6534139; rs10013305; rs1155577; rs2622496; rs2389868; rs7678400; rs2622497; rs2306455; rs3733520; rs1480936; rs6853998; rs2086450; rs13121569; rs10012485; rs13134665; rs3822191; rs7692994; rs12648259; rs2389863; rs3756156; rs2127823; rs11933966; rs10019674; rs3822194; rs10518333; rs3822192; rs7659250; rs10004484; rs11724055; rs3775856; rs2715020; rs10518336; rs3775848; rs7697823; rs10031665; rs3733525; rs3775843; rs10518335; rs6844263; rs7695620; rs10034450; rs10016736; rs3822190; rs3733524; rs3775858; rs7439678; rs3756155; rs17292047; rs13149407; rs7680748; rs7680063; rs7684899; rs3775846; rs17050695; rs12108288; rs17358524; rs11737395; rs17358860; rs9995026; rs4834784; rs13125819; rs7664986; rs4513554; rs3733521; rs3775850; rs1552092; rs11723090; rs2389864; rs2170276; rs13119104; rs3822193; rs3822195; rs7670921; rs10031483; rs3756154; rs10434031; rs2257018; rs6858592; rs7658561; rs3775851; rs3733519; rs4834787; rs6847818; rs6843229; rs2928991; rs7441716; rs10032392; rs10471013; rs6835635; rs34676199; rs6842674; rs17007201; rs4146266; rs10023384; rs4834786; rs10003953; rs13104219; rs11936555; rs2892869; rs7662636; rs6858777; rs6822275; rs13120581; rs10029882; rs2389867; rs11936841; rs7657515; rs17357499; rs12503853; rs11942898; rs6845402; rs3836705; rs9998919; rs17050700; rs10027735; rs9762527; rs10021460; rs4001175; rs2953292; rs2127827; rs12503809; rs12503898; rs7657849; rs17357002; rs3775842; rs10032993; rs9307478; rs2306457; rs1552094; rs3832310; rs11728616; rs2389870; rs10018280; rs10031328; rs17358475; rs3775841; rs6833334; rs12648182; rs17007576; rs17051261; rs1480934; rs2892867; rs2127826; rs10021823; rs12498539; rs13103899; rs6834347; rs9884402; rs4264816; rs2715022; rs11098533; rs17051262; rs6534141; rs6829903; rs2389865; rs9997423; rs12502531; rs17007472; rs7669520; rs2389871; rs3806808; rs17005698; rs6834796; rs13116789; rs35062994; rs2389884; rs11363700; rs10025536; rs13136462; rs35938775; rs8180145; rs10615829; rs28566610; rs10021469; rs28419430; rs9992502; rs11290659; rs35004652; rs6817317; rs13118388; rs13122502; rs5861435; rs7681980; rs10711029; rs35748413; rs35455771; rs13136296; rs35454723; rs34901236; rs35101570; rs34918444; rs12504983; rs28469881; rs34601943; rs1045157; rs35758637; rs11324618; rs35620864; rs28450144; rs35105657; rs35566617; rs35184157; rs34269739; rs34089664; rs3839163; rs33918643; rs34202789; rs12648652; rs28415331; rs10536068; rs11453574; rs35081967; rs10155235; rs35432148; rs35967840; rs35674158; rs9307480; rs11334790; rs10013852; rs3056860; rs3056797; rs5861432; rs11295209; rs10706998; rs34945097; rs35264119; rs13140497; rs11352066; rs34521874; rs3775849; rs35182804; rs13140391; rs35189456; rs28736368; rs36026032; rs3775855; rs11392885; rs35576199; rs3832309; rs4337718; rs35999787; rs33952829; rs3836709; rs2928994; rs33963018; rs11343673; rs34825792; rs28405434; rs28625289; rs36170021; rs5861429; rs10021318; rs10213498; rs35236680; rs35535411; rs35412284; rs9884290; rs12331661; rs2715015; rs34712759; rs34873286; rs5861431; rs11455919; rs2928995; rs34978491; rs28576329; rs35960124; rs35111518; rs3733522; rs35852479; rs10031926; rs10213673; rs36173322; rs28735358; rs13115778; rs33940010; rs28375929; rs13147578; rs35409170; rs41278071; rs34944084; rs36046509; rs36159601; rs11931723; rs13137511; rs7692325; rs34830431; rs34698887; rs41464847; rs28540362; rs4834783; rs28718422; rs35777352; rs35289699; rs7685157; rs34868248; rs34368241; rs10010096; rs35906047; rs5861433; rs5861434; rs34847681; rs2928992; rs7694813; rs36137103; rs28621505; rs34160653; rs10015714; rs35201113; rs34036667; rs12505618; rs33944872; rs4834782; rs12108603; rs28394116; rs12331968; rs28382361; rs12508098; rs33926198; rs7678973; rs11299247; rs12644001; rs35813548; rs11438089; rs28639494; rs13103510; rs10697082; rs13133969; rs4340778; rs35507637; rs2928993; rs34492508; rs2622501; rs2715019; rs34840968; rs35233299; rs28394320; rs17291073; rs10696044; rs10710194; rs28380652; rs35466933; rs28634062; rs35172283; rs6854072; rs28461667; rs13152138; rs10612127; rs33935566; rs3836706; rs35865360; rs35632964; rs2715016; rs11945344; rs35852065; rs36191671; rs10434030; rs34294229; rs10696018; rs9994195; rs34146690; rs9998244; rs33937429; rs3214947; rs34463475; rs33977085; rs41278067; rs35791145; rs3836707; rs34025740; rs36108275; rs34504999; rs4604044; rs4001176; rs35326039; rs2622495; rs7691391; rs34308924; rs28412979; rs28622960; rs28685688; rs34772207; rs35595874; rs36040693; rs36192830; rs34426121; rs11945339; rs34892273; rs34255091; rs13140409; rs28650385; rs2622498; rs35519053; rs34129926; rs10640351; rs9998095; rs9996803; rs10579225; rs10545059; rs34002300; rs34244089; rs35539932; rs13140150; rs2306458; rs9884862; rs34767405; rs3836710; rs35108769; rs17356245; rs36197915; rs36098810; rs2622503; rs4998488; rs5861430; rs34123358; rs35850447; rs34580725; rs3836708; rs35609470; rs34953413; rs28564258; rs4596225; rs2928996; rs2622502; rs33998714; rs13137618; rs33944547; rs722667; rs35361251; rs34473068; rs35151809; rs10028249; rs10641710; rs41278069; rs2892868; rs11289914; rs10003668; rs34910273; rs28678287; rs34575312; rs34309305; rs11356355; rs11269159; rs33990318; rs28590372; rs34347414; rs11297755; rs35585470; rs35298888; rs36195333; rs34672540; rs28626938; rs9307477; rs28372207; rs34804498; rs4146268; rs722668; rs1552093; rs11551967; rs36196342; rs1480935; rs10010097; rs12649367; rs5020222; rs34009787; rs34884781; rs33993326; rs36194561; rs28615474; rs34736985; rs11408932; rs3840504; rs33930936; rs34480487; rs33982542; rs11342908; rs13149629; rs28653590; rs2953291; rs35952089; rs10643383; rs10639733; rs11344214; rs35833768; rs10006525; rs10006706; rs10009566; rs10017842; rs11098530; rs11935596; rs11940028; rs11940549; rs12507964; rs12508504; rs13145352; rs2389878; rs4834792; rs6849171; rs6849561; rs7675276; rs7681544

# Metabolic_Enzyme_116_General_References:
9714779; 9716380; 9642111; 10393044; 12955149

# Metabolic_Enzyme_116_References:
Not Available

# Metabolic_Enzyme_117_ID:
5928

# Metabolic_Enzyme_117_Name:
Argininosuccinate synthase

# Metabolic_Enzyme_117_Synonyms:
Citrulline--aspartate ligase

# Metabolic_Enzyme_117_Gene_Name:
ASS1

# Metabolic_Enzyme_117_Protein_Sequence:
>Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK

# Metabolic_Enzyme_117_Number_of_Residues:
412

# Metabolic_Enzyme_117_Molecular_Weight:
46531

# Metabolic_Enzyme_117_Theoretical_pI:
8.18

# Metabolic_Enzyme_117_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  argininosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_117_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_117_Specific_Function:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + omega-N-(L-arginino)succinate

# Metabolic_Enzyme_117_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_117_Reaction:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate

# Metabolic_Enzyme_117_Pfam_Domain_Function:
PF00764:Arginosuc_synth

# Metabolic_Enzyme_117_Signals:
None

# Metabolic_Enzyme_117_Transmembrane_Regions:
None

# Metabolic_Enzyme_117_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_117_EC_Link:
EC 6.3.4.5

# Metabolic_Enzyme_117_GenBank_ID_Protein:
28872

# Metabolic_Enzyme_117_SwissProt_ID:
ASSY_HUMAN (P00966)

# Metabolic_Enzyme_117_swissprot_Name:
Not Available

# Metabolic_Enzyme_117_Genecard_id:
ASS1

# Metabolic_Enzyme_117_Geneatlas_id:
ASS1

# Metabolic_Enzyme_117_hgnc_id:
HGNC:758

# Metabolic_Enzyme_117_PDB_ID:
Not Available

# Metabolic_Enzyme_117_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_117_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_117_Subcellular_Location:
Not Available

# Metabolic_Enzyme_117_Gene_Sequence:
>1239 bp
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTACGGCCTAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG

# Metabolic_Enzyme_117_GenBank_ID_Gene:
X01630

# Metabolic_Enzyme_117_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_117_Locus:
9q34.1

# Metabolic_Enzyme_117_SNPs:
rs10901072; rs877326; rs4740158; rs6597680; rs7040665; rs11243372; rs12554609; rs12004384; rs10901047; rs914983; rs12380009; rs4740435; rs10121847; rs7042129; rs10123082; rs1760275; rs11244382; rs12685110; rs474330; rs553696; rs596317; rs506705; rs602924; rs504752; rs1215983; rs6597499; rs1215971; rs1215980; rs493389; rs543048; rs1215984; rs634432; rs666174; rs914971; rs1215970; rs1653332; rs10901080; rs590086; rs1215979; rs502901; rs666971; rs1215985; rs1215990; rs12555797; rs554629; rs7860909; rs3780588; rs1215986; rs12005118; rs1215972; rs7036163; rs2043189; rs2282219; rs914970; rs480313; rs1215988; rs12551145; rs17147029; rs2991273; rs12375699; rs641510; rs486889; rs7018779; rs17147023; rs506626; rs1215981; rs10114424; rs544701; rs618504; rs11243414; rs4322051; rs548262; rs1615006; rs11789315; rs1215982; rs12340606; rs529569; rs17147021; rs507351; rs1215991; rs7039110; rs7851267; rs1864708; rs1619401; rs652313; rs502166; rs10122141; rs668738; rs476067; rs2043191; rs10901085; rs580228; rs1215978; rs2043190; rs12003032; rs12553162; rs17147018; rs1215940; rs566037; rs640181; rs7847222; rs12000999; rs1760253; rs12343715; rs1215975; rs11243474; rs12377651; rs1215987; rs7040689; rs1215976; rs584157; rs4032; rs540140; rs4740430; rs928518; rs7854616; rs688430; rs35269064; rs11549769; rs1057484; rs35772983; rs3208841; rs2297599; rs13440219; rs13290196; rs35463800; rs11243377; rs12685093; rs3012668; rs35902422; rs5900898; rs11272909; rs3085579; rs10121464; rs28534724; rs11337242; rs28511880; rs13293193; rs35000413; rs5900899; rs12340634; rs41296095; rs35487019; rs1215977; rs35835384; rs34768057; rs3780589; rs34339017; rs11243481; rs34029710; rs34271203; rs11271310; rs11243542; rs13301636; rs12171726; rs34273046; rs4740317; rs35512453; rs1653340; rs34362653; rs34654848; rs1653334; rs11243500; rs35852270; rs12376592; rs35568745; rs12343078; rs11243395; rs28440121; rs34248043; rs12378416; rs1215941; rs12375712; rs28665572; rs11243405; rs35797527; rs4740239; rs2313201; rs884804; rs3030699; rs34037515; rs35769425; rs34790521; rs1215989; rs35976100; rs35015356; rs2297598; rs10114733; rs6151195; rs41302903; rs928517; rs12344308; rs2915535; rs28634784; rs35889473; rs884803; rs35476109; rs34850609; rs596698; rs13288900; rs34421800; rs35943966; rs534737; rs28530182; rs2116393; rs11243400; rs35581111; rs12553789; rs28633982; rs4740161; rs34599158; rs35204727; rs631908; rs13288740; rs7025952; rs1467802; rs11788148; rs35842179; rs11243523; rs11243545; rs7030804; rs34149601; rs7855232; rs35220375; rs28587006; rs11244367; rs12352216; rs11244364; rs7043097; rs34734822; rs36233815; rs2071367; rs35688375; rs10793902; rs10901110; rs11244343; rs12236605; rs12337532; rs12342208; rs12345660; rs2313079; rs3087691; rs4237122; rs7041914; rs7851772; rs7865294; rs7869828; rs928516

# Metabolic_Enzyme_117_General_References:
6194510; 6321498; 11941481; 2788888; 9150948; 2358466; 1943692; 7977368; 8792870; 11708871; 12815590

# Metabolic_Enzyme_117_References:
Not Available

# Metabolic_Enzyme_118_ID:
5929

# Metabolic_Enzyme_118_Name:
AMP deaminase 1

# Metabolic_Enzyme_118_Synonyms:
Myoadenylate deaminase; AMP deaminase isoform M

# Metabolic_Enzyme_118_Gene_Name:
AMPD1

# Metabolic_Enzyme_118_Protein_Sequence:
>AMP deaminase 1
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE

# Metabolic_Enzyme_118_Number_of_Residues:
747

# Metabolic_Enzyme_118_Molecular_Weight:
86491

# Metabolic_Enzyme_118_Theoretical_pI:
6.89

# Metabolic_Enzyme_118_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_118_General_Function:
Not Available

# Metabolic_Enzyme_118_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_118_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_118_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_118_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_118_Signals:
None

# Metabolic_Enzyme_118_Transmembrane_Regions:
None

# Metabolic_Enzyme_118_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_118_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_118_GenBank_ID_Protein:
10864686

# Metabolic_Enzyme_118_SwissProt_ID:
AMPD1_HUMAN (P23109)

# Metabolic_Enzyme_118_swissprot_Name:
Not Available

# Metabolic_Enzyme_118_Genecard_id:
AMPD1

# Metabolic_Enzyme_118_Geneatlas_id:
AMPD1

# Metabolic_Enzyme_118_hgnc_id:
HGNC:468

# Metabolic_Enzyme_118_PDB_ID:
Not Available

# Metabolic_Enzyme_118_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_118_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_118_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_118_Gene_Sequence:
>2244 bp
ATGCCTCTGTTCAAACTCCCAGCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTT
GCTGAAAAAGTGTTTGCCTCTGAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCC
TTTGATGTGGATGAGATCTGTCCGATTTCTCATCATGAGATGCAAGCACACATATTCCAT
CTGGAGACTCTGTCCACCTCCACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAG
ACTGTTAATTTGTCCATTCCACTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGAT
GAATACATTTCCTCATCTCCAACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATT
ACTGGTGACTATGCCTCTGGGGTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTG
TATCGGGCACTATGCATACGTGAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAA
ACCCCTTCCAAATACTTGCGGAACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTC
TATCCAGTCTTTACTCCTCCTGTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTT
CCTGAAAACCTGGGCTATCACCTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAAT
GAAGCAGCAGTCAGCAAAGATGAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTC
TTAGACGATATGAATTTTTTACTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACC
CACCGGCGCCTGAAGTTCCTCTCCTCGAAGTTCCAGGTCCATCAGATGCTTAACGAGATG
GACGAGTTAAAGGAGCTGAAAAACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTG
GACACCCATATCCATGCAGCCGCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAG
AAATCTTACCAAATTGATGCTGACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACC
CTAAAGGAACTTTTTGCTAAATTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTG
GATGTTCATGCTGGACGCCAGACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAAT
CCTGTAGGAGCAAGTGAGCTACGGGACCTCTACTTGAAGACAGACAATTACATTAATGGG
GAATATTTTGCCACTATCATCAAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAG
CATGCTGAGCCCCGCCTGTCCATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCC
TCCTGGTTCGTCTGCAATCGCATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCC
AGGATCTATGATGTGTTCCGTTCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAG
AATATTTTCATGCCAGTGTTTGAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGT
GTCTTCCTCAAGCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGC
CACATGTTCTCCTCCAAGAGTCCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCT
TACACTTACTATGCCTACTACATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAG
GAACGAGGCATGAATACGTTTCTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACC
CATCTCATGACAGCATTCATGATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG
AGTCCCGTGCTACAGTACTTGTTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTA
AGTAACAATAGCCTATTTCTAGAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAA
GGGCTAATGATCTCACTGTCTACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCC
CTAATGGAAGAATATGCTATTGCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGC
GAAGTGGCAAGGAACAGTGTCTTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTT
CTGGGCGACAATTACCTTGAGGAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTA
GCCCAAATCCGCATGGCCTATCGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCT
GAGGGTCTTAAATCAACAGAATAA

# Metabolic_Enzyme_118_GenBank_ID_Gene:
M37931

# Metabolic_Enzyme_118_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_118_Locus:
1p13

# Metabolic_Enzyme_118_SNPs:
rs17602729; rs12566550; rs2268697; rs2010899; rs2268701; rs2336363; rs761755; rs2268700; rs2268699; rs2070986; rs743041; rs6679869; rs7531877; rs12407408; rs6683173; rs1884296; rs2268698; rs3789627; rs7515356; rs11585780; rs17032832; rs6678312; rs11102831; rs11589112; rs6697362; rs12132598; rs6663302; rs12038990; rs2268696; rs11588144; rs926938; rs6667218; rs34526199; rs35859650; rs2273268; rs34778674; rs34287100; rs949421; rs35197706; rs34257411; rs12096667; rs11451311; rs34245099; rs7518060; rs35468504; rs10698057; rs35746234; rs34418559; rs34741374; rs34355177; rs10601370; rs33984400; rs7541903; rs35241478; rs6656110; rs34630625; rs12036263; rs35985810; rs6685096; rs11412027; rs7543893; rs12354159; rs10645732; rs10611520; rs6701394; rs6701427; rs915955; rs737549; rs34909498; rs35027577; rs6697757; rs10776787; rs11577646; rs11587596; rs11799831; rs11801474; rs11803022; rs12564817; rs12753208; rs17032822; rs4537551; rs4839014; rs6537843; rs6695699; rs7516111

# Metabolic_Enzyme_118_General_References:
2345176; 1370861; 1631143; 11102975

# Metabolic_Enzyme_118_References:
Not Available

# Metabolic_Enzyme_119_ID:
5314

# Metabolic_Enzyme_119_Name:
Soluble calcium-activated nucleotidase 1

# Metabolic_Enzyme_119_Synonyms:
SCAN-1; Apyrase homolog; Putative NF-kappa-B-activating protein 107; Putative MAPK-activating protein PM09

# Metabolic_Enzyme_119_Gene_Name:
CANT1

# Metabolic_Enzyme_119_Protein_Sequence:
>Soluble calciumactivated nucleotidase 1
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLC
SHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQ
EENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSV
DDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDV
VNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPR
RASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVA
LKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI

# Metabolic_Enzyme_119_Number_of_Residues:
401

# Metabolic_Enzyme_119_Molecular_Weight:
44840

# Metabolic_Enzyme_119_Theoretical_pI:
5.98

# Metabolic_Enzyme_119_GO_Classification:
Not Available

# Metabolic_Enzyme_119_General_Function:
Not Available

# Metabolic_Enzyme_119_Specific_Function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP

# Metabolic_Enzyme_119_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_119_Reaction:
A nucleoside diphosphate + H2O = a nucleotide + phosphate

# Metabolic_Enzyme_119_Pfam_Domain_Function:
PF06079:Apyrase

# Metabolic_Enzyme_119_Signals:
None

# Metabolic_Enzyme_119_Transmembrane_Regions:
45-62

# Metabolic_Enzyme_119_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_119_EC_Link:
EC 3.6.1.6

# Metabolic_Enzyme_119_GenBank_ID_Protein:
22218108

# Metabolic_Enzyme_119_SwissProt_ID:
CANT1_HUMAN (Q8WVQ1)

# Metabolic_Enzyme_119_swissprot_Name:
Not Available

# Metabolic_Enzyme_119_Genecard_id:
CANT1

# Metabolic_Enzyme_119_Geneatlas_id:
CANT1

# Metabolic_Enzyme_119_hgnc_id:
HGNC:19721

# Metabolic_Enzyme_119_PDB_ID:
1S1D

# Metabolic_Enzyme_119_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_119_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_119_Subcellular_Location:
Intracytoplasmic membrane; single-pass type II membrane protein. Processed form:Secreted protein

# Metabolic_Enzyme_119_Gene_Sequence:
>1116 bp
ATGACCAAGGCCGCGGACCCCCGCTTCCGCCCCCGCTGGAAGGTGATCCTGACGTTCTTT
GTGGGTGCTGCCATCCTCTGGCTGCTCTGCTCCCACCGCCCGGCCCCCGGCAGGCCCCCC
ACCCACAATGCACACAACTGGAGGCTCGGCCAGGCGCCCGCCAACTGGTACAATGACACC
TACCCCCTGTCTCCCCCACAAAGGACACCGGCTGGGATTCGGTATCGAATCGCAGTTATC
GCAGACCTGGACACAGAGTCAAGGGCCCAAGAGGAAAACACCTGGTTCAGTTACCTGAAA
AAGGGCTACCTGACCCTGTCAGACAGTGGGGACAAGGTGGCCGTGGAATGGGACAAAGAC
CATGGGGTCCTGGAGTCCCACCTGGCGGAGAAGGGGAGAGGCATGGAGCTATCCGACCTG
ATTGTTTTCAATGGGAAACTCTACTCCGTGGATGACCGGACGGGGGTCGTCTACCAGATC
GAAGGCAGCAAAGCCGTGCCCTGGGTGATTCTGTCCGACGGCGACGGCACCGTGGAGAAA
GGCTTCAAGGCCGAATGGCTGGCAGTGAAGGACGAGCGTCTGTACGTGGGCGGCCTGGGC
AAGGAGTGGACGACCACTACGGGTGATGTGGTGAACGAGAACCCGGAGTGGGTGAAGGTG
GTGGGCTACAAGGGCAGCGTGGACCACGAGAACTGGGTGTCCAACTACAACGCCCTGCGG
GCTGCTGCCGGCATCCAGCCGCCAGGCTACCTCATCCATGAGTCTGCCTGCTGGAGTGAC
ACGCTGCAGCGCTGGTTCTTCCTGCCGCGCCGCGCCAGCCAGGAGCGCTACAGCGAGAAG
GACGACGAGCGCAAGGGCGCCAACCTGCTGCTGAGCGCCTCCCCTGACTTCGGCGACATC
GCTGTGAGCCACGTCGGGGCGGTGGTCCCCACTCACGGCTTCTCGTCCTTCAAGTTCATC
CCCAACACCGACGACCAGATCATTGTGGCCCTCAAATCCGAGGAGGACAGCGGCAGAGTC
GCCTCCTACATCATGGCCTTCACGCTGGACGGGCGCTTCCTGTTGCCGGAGACCAAGATC
GGAAGCGTGAAATACGAAGGCATCGAGTTCATTTAA

# Metabolic_Enzyme_119_GenBank_ID_Gene:
AF328554

# Metabolic_Enzyme_119_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_119_Locus:
17q25.3

# Metabolic_Enzyme_119_SNPs:
rs8077024; rs35290882; rs35324359; rs2377301; rs9916285; rs3744171; rs4789903; rs9896857; rs4789848; rs12450407; rs7214331; rs12450128; rs4789847; rs4861; rs11891; rs17739056; rs12452918; rs3744173; rs12949479; rs16971940; rs8079368; rs4789904; rs9904301; rs3744170; rs12452876; rs3744168; rs9915230; rs12452980; rs12451303; rs11546278; rs34082669; rs9903215; rs3803781; rs1127654; rs34461224; rs2377010; rs5017245; rs34435616; rs5017244; rs35308608; rs35755919; rs7219932; rs28627413; rs8078860; rs34996994; rs12936828; rs9899883; rs35356398; rs34938499; rs5017243; rs34572362; rs14791; rs4789849; rs34891215; rs2377009; rs34097366; rs35738150; rs5017242; rs3038740; rs35518955; rs9891726; rs3744169; rs12939358; rs12939350; rs12939399; rs4497730; rs6501274; rs9914188

# Metabolic_Enzyme_119_General_References:
12234496; 12761501; 12167635

# Metabolic_Enzyme_119_References:
Not Available

# Metabolic_Enzyme_120_ID:
5506

# Metabolic_Enzyme_120_Name:
Phenylalanyl-tRNA synthetase alpha chain

# Metabolic_Enzyme_120_Synonyms:
Phenylalanine--tRNA ligase alpha chain; PheRS; CML33

# Metabolic_Enzyme_120_Gene_Name:
FARSA

# Metabolic_Enzyme_120_Protein_Sequence:
>PhenylalanyltRNA synthetase alpha chain
MADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKH
WELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAA
DGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSA
FSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLE
MGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTH
SQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNE
TLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVF
SYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGH
KVNLQMVYDSPLCRLDAEPRPPPTQEAA

# Metabolic_Enzyme_120_Number_of_Residues:
508

# Metabolic_Enzyme_120_Molecular_Weight:
57564

# Metabolic_Enzyme_120_Theoretical_pI:
7.96

# Metabolic_Enzyme_120_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  RNA ligase activity
Function:  tRNA ligase activity
Function:  phenylalanine-tRNA ligase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  RNA metabolism
Process:  tRNA metabolism
Process:  tRNA aminoacylation
Process:  tRNA aminoacylation for protein translation
Process:  phenylalanyl-tRNA aminoacylation
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_120_General_Function:
Translation, ribosomal structure and biogenesis 

# Metabolic_Enzyme_120_Specific_Function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_120_Pathway:
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis;
 map00970  Aminoacyl-tRNA biosynthesis

# Metabolic_Enzyme_120_Reaction:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

# Metabolic_Enzyme_120_Pfam_Domain_Function:
PF08279:HTH_11;
PF01409:tRNA-synt_2d

# Metabolic_Enzyme_120_Signals:
None

# Metabolic_Enzyme_120_Transmembrane_Regions:
None

# Metabolic_Enzyme_120_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_120_EC_Link:
EC 6.1.1.20

# Metabolic_Enzyme_120_GenBank_ID_Protein:
2102679

# Metabolic_Enzyme_120_SwissProt_ID:
SYFA_HUMAN (Q9Y285)

# Metabolic_Enzyme_120_swissprot_Name:
Not Available

# Metabolic_Enzyme_120_Genecard_id:
FARSA

# Metabolic_Enzyme_120_Geneatlas_id:
FARSA

# Metabolic_Enzyme_120_hgnc_id:
HGNC:3592

# Metabolic_Enzyme_120_PDB_ID:
Not Available

# Metabolic_Enzyme_120_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_120_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_120_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_120_Gene_Sequence:
>1527 bp
ATGGCGGATGGTCAGGTGGCGGAACTGCTGCTCCGGCGGCTGGAGGCGTCTGATGGCGGC
CTGGACAGCGCCGAGTTGGCGGCTGAGCTGGGCATGGAGCACCAGGCGGTGGTGGGCGCC
GTGAAGAGCCTTCAGGCGCTGGGCGAGGTCATCGAGGCTGAACTTCGGTCCACCAAGCAC
TGGGAGCTTACTGCGGAGGGCGAGGAGATTGCCCGGGAGGGCAGCCATGAGGCCCGTGTG
TTTCGAAGCATTCCCCCAGAGGGCCTGGCCCAGAGCGAGCTTATGCGACTGCCCAGTGGC
AAAGTGGGCTTCAGCAAGGCCATGTCCAACAAGTGGATTCGGGTGGACAAGAGTGCGGCT
GACGGGCCCCGGGTGTTCCGAGTGGTGGACAGCATGGAGGATGAGGTGCAGCGGCGGCTC
CAGCTGGTCCGGGGGGGACAGGCTGAGAAGCTGGGGGAGAAGGAGAGGAGCGAGCTGAGG
AAGAGGAAGCTGTTGGCTGAAGTGACTCTGAAGACCTACTGGGTGAGCAAAGGCAGTGCC
TTTAGTACCAGCATCTCCAAGCAAGAGACAGAGCTGAGCCCAGAGATGATCTCCAGTGGC
TCTTGGCGGGACCGGCCCTTCAAGCCCTACAACTTCTTGGCCCACGGTGTCCTCCCCGAC
AGCGGCCACCTTCACCCGCTGCTCAAGGTCCGCTCCCAGTTCCGACAGATCTTCCTGGAG
ATGGGGTTCACCGAGATGCCGACTGATAACTTCATTGAGAGCTCCTTCTGGAACTTTGAC
GCCCTCTTCCAGCCCCAGCAGCACCCAGCCCGTGACCAGCACGACACCTTCTTCCTTCGA
GATCCAGCGGAGGCCCTGCAGCTCCCAATGGACTATGTCCAGCGGGTCAAGCGGACCCAC
TCTCAGGGCGGCTACGGCTCACAGGGGTACAAGTATAACTGGAAGCTGGACGAGGCCCGG
AAAAACCTACTGCGAACCCACACCACATCAGCCAGCGCCCGTGCGCTCTACCGCCTTGCC
CAGAAGAAGCCCTTCACTCCGGTCAAGTACTTCTCCATCGACCGCGTATTCCGGAATGAG
ACCCTGGACGCCACGCACCTGGCTGAGTTCCACCAGATCGAGGGCGTGGTGGCGGATCAT
GGTCTCACCTTGGGCCACCTCATGGGCGTTCTGCGGGAGTTCTTCACCAAGCTGGGTATC
ACGCAACTCCGCTTCAAGCCAGCCTACAACCCATACACAGAGCCCAGCATGGAGGTGTTC
AGCTACCACCAAGGCCTGAAGAAGTGGGTGGAGGTCGGAAACTCGGGGGTCTTCCGTCCA
GAGATGCTGCTGCCCATGGGGCTTCCCGAGAACGTGTCGGTCATTGCCTGGGGCCTCTCC
CTGGAGCGCCCAACGATGATCAAATATGGCATCAACAATATCCGGGAGCTGGTGGGCCAC
AAGGTGAACCTGCAGATGGTGTATGACAGTCCCCTGTGCCGCCTGGATGCCGAGCCGAGG
CCCCCTCCCACACAGGAGGCTGCGTGA

# Metabolic_Enzyme_120_GenBank_ID_Gene:
U07424

# Metabolic_Enzyme_120_Chromosome_Location:
Not Available

# Metabolic_Enzyme_120_Locus:
Not Available

# Metabolic_Enzyme_120_SNPs:
Not Available

# Metabolic_Enzyme_120_General_References:
9177188; 10049785; 12665801

# Metabolic_Enzyme_120_References:
Not Available

# Metabolic_Enzyme_121_ID:
5235

# Metabolic_Enzyme_121_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_121_Synonyms:
dCK

# Metabolic_Enzyme_121_Gene_Name:
DCK

# Metabolic_Enzyme_121_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_121_Number_of_Residues:
260

# Metabolic_Enzyme_121_Molecular_Weight:
30519

# Metabolic_Enzyme_121_Theoretical_pI:
4.88

# Metabolic_Enzyme_121_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_121_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_121_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_121_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_121_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_121_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_121_Signals:
None

# Metabolic_Enzyme_121_Transmembrane_Regions:
None

# Metabolic_Enzyme_121_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_121_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_121_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_121_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_121_swissprot_Name:
Not Available

# Metabolic_Enzyme_121_Genecard_id:
DCK

# Metabolic_Enzyme_121_Geneatlas_id:
DCK

# Metabolic_Enzyme_121_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_121_PDB_ID:
1P62

# Metabolic_Enzyme_121_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_121_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_121_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_121_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_121_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_121_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_121_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_121_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_121_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_121_References:
Not Available

# Metabolic_Enzyme_122_ID:
5930

# Metabolic_Enzyme_122_Name:
Selenide, water dikinase 2

# Metabolic_Enzyme_122_Synonyms:
Selenophosphate synthetase 2; Selenium donor protein 2

# Metabolic_Enzyme_122_Gene_Name:
SEPHS2

# Metabolic_Enzyme_122_Protein_Sequence:
>Selenide, water dikinase 2
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGC
GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMD
SCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVS
QSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPD
SAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNR
TAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRF
GLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKP
RVIEVLPRGATAAVLAPDSSNASSEPSS

# Metabolic_Enzyme_122_Number_of_Residues:
448

# Metabolic_Enzyme_122_Molecular_Weight:
47259

# Metabolic_Enzyme_122_Theoretical_pI:
5.69

# Metabolic_Enzyme_122_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  selenide, water dikinase activity
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_122_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_122_Specific_Function:
Synthesizes selenophosphate from selenide and ATP

# Metabolic_Enzyme_122_Pathway:
map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_122_Reaction:
ATP + selenide + H2O = AMP + selenophosphate + phosphate

# Metabolic_Enzyme_122_Pfam_Domain_Function:
PF00586:AIRS;
PF02769:AIRS_C

# Metabolic_Enzyme_122_Signals:
None

# Metabolic_Enzyme_122_Transmembrane_Regions:
None

# Metabolic_Enzyme_122_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_122_EC_Link:
EC 2.7.9.3

# Metabolic_Enzyme_122_GenBank_ID_Protein:
14717790

# Metabolic_Enzyme_122_SwissProt_ID:
SPS2_HUMAN (Q99611)

# Metabolic_Enzyme_122_swissprot_Name:
Not Available

# Metabolic_Enzyme_122_Genecard_id:
SEPHS2

# Metabolic_Enzyme_122_Geneatlas_id:
SEPHS2

# Metabolic_Enzyme_122_hgnc_id:
HGNC:19686

# Metabolic_Enzyme_122_PDB_ID:
Not Available

# Metabolic_Enzyme_122_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_122_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_122_Subcellular_Location:
Not Available

# Metabolic_Enzyme_122_Gene_Sequence:
>1347 bp
ATGGCGGAAGCCTCGGCGACGGGCGCCTGCGGAGAGGCGATGGCAGCGGCGGAAGGCTCC
TCGGGCCCGGCGGGCTTGACTCTGGGCCGGAGCTTCTCGAACTACCGGCCCTTCGAGCCC
CAGGCGTTGGGCCTCAGCCCGAGCTGGCGGCTGACGGGCTTCTCCGGCATGAAGGGCTGA
GGCTGCAAGGTCCCGCAGGAGGCGCTGCTCAAACTCCTGGCGGGACTGACGCGGCCGGAC
GTGCGGCCCCCGCTGGGCCGGGGCCTGGTGGGTGGCCAGGAAGAGGCGTCCCAGGAAGCC
GGCCTGCCGGCAGGAGCGGGCCCCAGCCCCACCTTTCCAGCCCTGGGCATCGGGATGGAC
TCCTGCGTCATCCCCCTGAGGCACGGGGGCCTGTCACTGGTGCAGACCACGGACTTCTTT
TACCCCTTGGTAGAAGATCCCTACATGATGGGGCGCATAGCTTGTGCCAACGTGCTGAGT
GACCTCTACGCCATGGGGATTACTGAGTGTGACAACATGTTGATGTTACTCAGCGTCAGC
CAGAGTATGAGTGAGGAGGAACGCGAAAAGGTAACGCCACTCATGGTCAAAGGCTTTCGG
GATGCGGCTGAGGAAGGAGGGACGGCAGTGACCGGTGGGCAAACGGTGGTCAACCCTTGG
ATTATAATCGGTGGAGTTGCCACTGTAGTATGCCAACCAAATGAGTTCATAATGCCGGAC
AGCGCCGTCGTTGGGGACGTGCTGGTGTTAACCAAACCGTTAGGAACCCAGGTTGCTGTC
AATGCCCACCAATGGCTGGATAATCCTGAAAGATGGAATAAAGTAAAGATGGTGGTCTCC
AGAGAAGAGGTGGAGCTGGCCTATCAGGAAGCCATGTTCAATATGGCTACCCTCAACAGA
ACTGCTGCAGGTTTAATGCACACATTTAATGCCCATGCGGCCACAGATATCACAGGCTTT
GGCATTCTAGGACACTCCCAGAACCTTGCAAAACAACAAAGAAATGAAGTGTCCTTTGTT
ATTCATAATCTGCCAATAATTGCCAAGATGGCTGCCGTCAGCAAGGCCAGTGGACGGTTT
GGGCTTCTTCAAGGAACCTCAGCTGAAACCTCTGGGGGATTACTGATTTGTCTGCCAAGA
GAACAGGCGGCTCGCTTTTGTTCTGAAATCAAATCCTCCAAGTACGGAGAGGGTCACCAA
GCGTGGATCGTTGGCATTGTGGAAAAGGGAAACCGAACGGCCCGGATCATTGACAAGCCG
CGAGTTATTGAAGTCCTGCCTCGTGGGGCCACAGCTGCTGTTCTTGCTCCTGACAGTTCA
AATGCCTCCTCTGAGCCTAGCTCGTGA

# Metabolic_Enzyme_122_GenBank_ID_Gene:
U43286

# Metabolic_Enzyme_122_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_122_Locus:
16p11.2

# Metabolic_Enzyme_122_SNPs:
Not Available

# Metabolic_Enzyme_122_General_References:
7588067; 8986768

# Metabolic_Enzyme_122_References:
Not Available

# Metabolic_Enzyme_123_ID:
5931

# Metabolic_Enzyme_123_Name:
Ubiquitin-conjugating enzyme E2 R1

# Metabolic_Enzyme_123_Synonyms:
Ubiquitin-protein ligase R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; E2- CDC34

# Metabolic_Enzyme_123_Gene_Name:
CDC34

# Metabolic_Enzyme_123_Protein_Sequence:
>Ubiquitinconjugating enzyme E2 R1
MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKA
RLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVDDPQSGELPSERWNPTQNV
RTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIRKQVLGTKVDAERDG
VKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEEEADSCFGDDEDDSGTEES

# Metabolic_Enzyme_123_Number_of_Residues:
236

# Metabolic_Enzyme_123_Molecular_Weight:
26737

# Metabolic_Enzyme_123_Theoretical_pI:
4.15

# Metabolic_Enzyme_123_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_123_General_Function:
Not Available

# Metabolic_Enzyme_123_Specific_Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin

# Metabolic_Enzyme_123_Pathway:
map04120  Ubiquitin mediated proteolysis

# Metabolic_Enzyme_123_Reaction:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

# Metabolic_Enzyme_123_Pfam_Domain_Function:
PF00179:UQ_con

# Metabolic_Enzyme_123_Signals:
None

# Metabolic_Enzyme_123_Transmembrane_Regions:
None

# Metabolic_Enzyme_123_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_123_EC_Link:
EC 6.3.2.19

# Metabolic_Enzyme_123_GenBank_ID_Protein:
388309

# Metabolic_Enzyme_123_SwissProt_ID:
UB2R1_HUMAN (P49427)

# Metabolic_Enzyme_123_swissprot_Name:
Not Available

# Metabolic_Enzyme_123_Genecard_id:
CDC34

# Metabolic_Enzyme_123_Geneatlas_id:
CDC34

# Metabolic_Enzyme_123_hgnc_id:
HGNC:1734

# Metabolic_Enzyme_123_PDB_ID:
Not Available

# Metabolic_Enzyme_123_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_123_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_123_Subcellular_Location:
Not Available

# Metabolic_Enzyme_123_Gene_Sequence:
>897 bp
ATTGCGGCGGCGCCAGAGCTGCTGGAGCGCTCGGGGTCCCCGGGCGGCGGCGGCGGCGCA
GAGGAGGAGGCAGGCGGCGGCCCCGGTGGCTCCCCCCCGGACGGTGCGCGGCCCGGCCCG
TCTCGCGAACTCGCGGTGGTCGCGCGGCCCCGCGCTGCTCCGACCCCGGGCCCCTCCGCC
GCCGCCATGGCTCGGCCGCTAGTGCCCAGCTCGCAGAAGGCGCTGCTGCTGGAGCTCAAG
GGGCTGCAGGAAGAGCCGGTCGAGGGATTCCGCGTGACACTGGTGGACGAGGGCGATCTA
TACAACTGGGAGGTGGCCATTTTCGGGCCCCCCAACACCTACTACGAGGGCGGCTACTTC
AAGGCGCGCCTCAAGTTCCCCATCGACTACCCATACTCTCCACCAGCCTTTCGGTTCCTG
ACCAAGATGTGGCACCCTAACATCTACGAGACGGGGGACGTGTGTATCTCCATCCTCCAC
CCGCCGGTGGACGACCCCCAGAGCGGGGAGCTGCCCTCAGAGAGGTGGAACCCCACGCAG
AACGTCAGGACCATTCTCCTGAGTGTGATCTCCCTCCTGAACGAGCCCAACACCTTCTCG
CCCGCAAACGTGGACGCCTCCGTGATGTACAGGAAGTGGAAAGAGAGCAAGGGGAAGGAT
CGGGAGTACACAGACATCATCCGGAAGCAGGTCCTGGGGACCAAGGTGGACGCGGAGCGT
GACGGCGTGAAGGTGCCCACCACGCTGGCCGAGTACTGCGTGAAGACCAAGGCGCCGGCG
CCCGACGAGGGCTCAGACCTCTTCTACGACGACTACTACGAGGACGGCGAGGTGGAGGAG
GAGGCCGACAGCTGCTTCGGGGACGATGAGGATGACTCTGGCACGGAGGAGTCCTGA

# Metabolic_Enzyme_123_GenBank_ID_Gene:
L22005

# Metabolic_Enzyme_123_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_123_Locus:
19p13.3

# Metabolic_Enzyme_123_SNPs:
rs6507; rs35573985; rs16990556; rs7150; rs7528; rs7529; rs16989752; rs16990665; rs16990659; rs892202; rs2396295; rs10402948; rs12976021; rs8104513; rs6510825; rs2011225; rs2011210; rs7254191; rs892204; rs892201; rs2011226; rs4919914; rs10415326; rs6510823; rs10853978; rs6510824; rs10853980; rs10853979; rs2011211; rs892203; rs11883123; rs1108113; rs17841746; rs17672563; rs2288952; rs11667548; rs17841766; rs7249135; rs7259421; rs4264506; rs12609463; rs10415110; rs12984645; rs16990634; rs2288956; rs11881685; rs2288951; rs12979110; rs3930364; rs12608630; rs10409849; rs1982084; rs12983064; rs2288955; rs1108115; rs2288954; rs16990625; rs17841738; rs3930363; rs10421502; rs7508345; rs16990590; rs7254483; rs1108114; rs2288953; rs16990597; rs12972025; rs12461965; rs17841732; rs4541184; rs8107361; rs7255072; rs12984443; rs16990500; rs2011204; rs16990648; rs17841733; rs17841729; rs16990626; rs17841735; rs16990622; rs12984468; rs16990508; rs16990539; rs16990638; rs17841752; rs16990510; rs16990893; rs16990550; rs12985200; rs16990600; rs16989782; rs17841737; rs17841748; rs10406729; rs10419323; rs16990506; rs16990502; rs17841731; rs17841750; rs7249253; rs3930365; rs17841754; rs10426138; rs16989793; rs16989750; rs16990493; rs16989748; rs17425549; rs16989726; rs17435422; rs16990498; rs16989712; rs16989728; rs17425535; rs16989724; rs16990494; rs16990650; rs16990554; rs11557525; rs16990654; rs11557524; rs16989755; rs16990656; rs1313711; rs7252421; rs11457359; rs11878756; rs7256168; rs12985246; rs16990532; rs12978889; rs5826698; rs16990585; rs11881969; rs16990583; rs16989783; rs7259097; rs12972728; rs16990571; rs17841765; rs7255299; rs12984199; rs17841742; rs17841759; rs12973414; rs34195292; rs41443449; rs16989771; rs16990628; rs16990514; rs16989788; rs12979793; rs17841747; rs16990568; rs17841736; rs16990517; rs11881961; rs1313710; rs5826699; rs16990605; rs17841762; rs12984708; rs17841751; rs17841758; rs28558712; rs36028188; rs12984899; rs16990594; rs16990610; rs16990522; rs1313713; rs16989781; rs34823529; rs34635182; rs16990537; rs17841775; rs36104500; rs17841760; rs12985216; rs16990616; rs17841755; rs12978637; rs28731438; rs28575072; rs16990545; rs16990608; rs12985212; rs12983594; rs16990892; rs34534471; rs3930362; rs12984900; rs34460804; rs16990542; rs28687356; rs12984950; rs12984940; rs17841761; rs17425573; rs35184527; rs16990530; rs12979642; rs5826700; rs12985201; rs17841749; rs12978802; rs12985264; rs1313712; rs17425542; rs16989733; rs16989717; rs16989721; rs11368160; rs16990496; rs16990492; rs16989730; rs16989741; rs16989739; rs5826697; rs16989736; rs34509095; rs16989743; rs11882673; rs12459388; rs12608511; rs12981692; rs1599882; rs1599883; rs1599884; rs1865117; rs2070794; rs2070795; rs2070796; rs2070797; rs2070798; rs2070799; rs2396293; rs2894583; rs3745923; rs3760874; rs3760879; rs3760880; rs3810355; rs3826891; rs4919841; rs4919846; rs745403; rs747354; rs892209

# Metabolic_Enzyme_123_General_References:
8248134; 10918611

# Metabolic_Enzyme_123_References:
Not Available

# Metabolic_Enzyme_124_ID:
5932

# Metabolic_Enzyme_124_Name:
DNA ligase 1

# Metabolic_Enzyme_124_Synonyms:
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1

# Metabolic_Enzyme_124_Gene_Name:
LIG1

# Metabolic_Enzyme_124_Protein_Sequence:
>DNA ligase 1
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY

# Metabolic_Enzyme_124_Number_of_Residues:
919

# Metabolic_Enzyme_124_Molecular_Weight:
101737

# Metabolic_Enzyme_124_Theoretical_pI:
5.30

# Metabolic_Enzyme_124_GO_Classification:
>>>
Function:  DNA ligase (ATP) activity
Function:  nucleic acid binding
Function:  DNA binding
Function:  DNA ligase (ATP) activity
Function:  DNA ligase (ATP) activity
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming phosphoric ester bonds
Function:  DNA ligase activity
Function:  DNA ligase (ATP) activity
 ||
>>>
Process:  DNA recombination
Process:  DNA repair
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  DNA metabolism
Process:  DNA replication
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_124_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_124_Specific_Function:
This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA

# Metabolic_Enzyme_124_Pathway:
Not Available

# Metabolic_Enzyme_124_Reaction:
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m

# Metabolic_Enzyme_124_Pfam_Domain_Function:
PF04679:DNA_ligase_A_C;
PF01068:DNA_ligase_A_M;
PF04675:DNA_ligase_A_N

# Metabolic_Enzyme_124_Signals:
None

# Metabolic_Enzyme_124_Transmembrane_Regions:
None

# Metabolic_Enzyme_124_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_124_EC_Link:
EC 6.5.1.1

# Metabolic_Enzyme_124_GenBank_ID_Protein:
187143

# Metabolic_Enzyme_124_SwissProt_ID:
DNL1_HUMAN (P18858)

# Metabolic_Enzyme_124_swissprot_Name:
Not Available

# Metabolic_Enzyme_124_Genecard_id:
LIG1

# Metabolic_Enzyme_124_Geneatlas_id:
LIG1

# Metabolic_Enzyme_124_hgnc_id:
HGNC:6598

# Metabolic_Enzyme_124_PDB_ID:
Not Available

# Metabolic_Enzyme_124_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_124_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_124_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_124_Gene_Sequence:
>2760 bp
ATGCAGCGAAGTATCATGTCATTTTTCCACCCCAAGAAAGAGGGTAAAGCAAAGAAGCCT
GAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAG
GAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCG
GCCCGGGTCCTGGGCAGCGAAGGGGAAGAGGAGGATGAAGCCCTTAGCCCTGCTAAAGGC
CAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAG
AACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAG
CGTCGCACAGCTCGGAAGCAGCTCCCGAAACGGACCATTCAGGAAGTCCTGGAAGAGCAG
AGTGAGGACGAGGACAGAGAAGCCAAGAGGAAGAAGGAGGAGGAAGAAGAGGAGACCCCG
AAAGAAAGCCTCACAGAGGCTGAAGTGGCAACAGAGAAGGAAGGAGAAGACGGGGACCAG
CCCACCACGCCTCCCAAGCCCCTAAAGACCTCCAAAGCAGAGACCCCGACGGAAAGCGTT
TCAGAGCCTGAGGTGGCCACGAAGCAGGAACTGCAGGAGGAGGAAGAGCAGACCAAGCCT
CCCCGCAGAGCTCCCAAGACGCTCAGCAGCTTCTTCACCCCCCGGAAGCCAGCAGTCAAA
AAAGAAGTGAAGGAAGAGGAGCCAGGGGCTCCAGGAAAGGAGGGAGCTGCTGAGGGACCC
CTGGATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGC
TGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAG
GAGGTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTG
GCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCA
CCCCAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAG
GCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGG
CTGGTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACT
GCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACA
GCCAAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGG
TTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTG
GCTGCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATG
GTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGC
ATGATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTG
CTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTG
AAACCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAG
GCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAA
GGCGGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGAC
ATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACC
GAAGCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACC
CGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTC
GACCTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAG
CTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGAC
ACCAAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAG
GGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCAC
AACTGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTG
GTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTG
GCCTCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGCTTGGAACTGGCTTC
AGTGATGAGGAGCTGGAGGAGCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCA
CGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCT
GTGTGGGAGGTGAAGTGCGCTGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGC
CTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAA
GACAAGCAGCCGGAGCAGGCCACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAA
AGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAA


# Metabolic_Enzyme_124_GenBank_ID_Gene:
M36067

# Metabolic_Enzyme_124_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_124_Locus:
19q13.2-q13.3

# Metabolic_Enzyme_124_SNPs:
rs3730911; rs3730933; rs3730980; rs3731003; rs4987068; rs11668325; rs3730966; rs11666150; rs3731008; rs3730863; rs20580; rs1803907; rs3731027; rs3730982; rs13436; rs20581; rs35100567; rs4987069; rs439132; rs2386522; rs20579; rs251692; rs10426471; rs2386521; rs3730844; rs12611390; rs12463259; rs3730843; rs12463260; rs12611384; rs3731047; rs2386523; rs2116492; rs102347; rs2163619; rs274892; rs156640; rs274893; rs7246512; rs3730858; rs3730946; rs3731029; rs411073; rs436303; rs1971775; rs274889; rs156634; rs416844; rs3730945; rs3730862; rs3730940; rs2304136; rs3730954; rs274883; rs3786764; rs3731030; rs3730931; rs3730857; rs3730898; rs3730942; rs274885; rs3730849; rs754948; rs8100261; rs4801749; rs3730913; rs3730901; rs3730860; rs187998; rs3730850; rs3730938; rs274884; rs3730943; rs3730990; rs3730865; rs175628; rs16981560; rs3730994; rs3730939; rs3730989; rs156641; rs2288882; rs3730951; rs7247570; rs251690; rs2060233; rs156637; rs187999; rs3730905; rs3730974; rs274860; rs3729512; rs156646; rs274862; rs3730883; rs175627; rs3730912; rs156639; rs3729518; rs153023; rs3729519; rs3730880; rs3731011; rs3730900; rs380487; rs3730926; rs9304673; rs3730987; rs3730914; rs3730872; rs3730908; rs3730869; rs251691; rs3730944; rs3730924; rs156638; rs442670; rs274897; rs7248694; rs3730886; rs9304672; rs3786763; rs392891; rs3730959; rs2060234; rs3730976; rs12462811; rs3730986; rs3730894; rs3730919; rs12985215; rs6509360; rs3730910; rs10420285; rs3729520; rs3731007; rs156633; rs3730903; rs7246229; rs3730932; rs3730920; rs2288881; rs5025733; rs166683; rs3731034; rs2241721; rs2288878; rs156645; rs10500298; rs3730881; rs274861; rs274898; rs3730887; rs2067286; rs3731004; rs2288879; rs3731013; rs3731014; rs3730867; rs3731023; rs3730873; rs3730969; rs156648; rs153021; rs3730878; rs870231; rs251699; rs8108486; rs3731044; rs3730876; rs3730882; rs3730917; rs11672629; rs3730856; rs156644; rs3730977; rs3730902; rs3731002; rs3730995; rs2060235; rs2915637; rs3730895; rs3730958; rs8108407; rs274896; rs10445576; rs3730915; rs3730897; rs3731037; rs3730889; rs8113271; rs3730853; rs156647; rs3731009; rs16981368; rs3731022; rs3730859; rs3731032; rs10409171; rs3730868; rs3730851; rs3731012; rs3731020; rs3730870; rs274886; rs3730922; rs10423203; rs3730961; rs3731043; rs3731005; rs3731015; rs3730864; rs12986286; rs3730885; rs3731035; rs8104114; rs201186; rs3729517; rs3730888; rs16981519; rs10420093; rs3730877; rs7252139; rs2288880; rs3730988; rs156643; rs12610623; rs3731024; rs3730921; rs3730996; rs4987071; rs3730909; rs419664; rs3078278; rs3730852; rs153022; rs16981356; rs3731036; rs2288883; rs3730861; rs3731050; rs3731052; rs3731049; rs3731051; rs4987181; rs11879148; rs3730855; rs4987070; rs34087182; rs3730947; rs12981963; rs35485148; rs11273301; rs5828336; rs3730845; rs12463269; rs12978112; rs28490966; rs8109984; rs35239737; rs10424875; rs34246370; rs34824188; rs3730847; rs12980783; rs34115345; rs34864830; rs3730999; rs34060696; rs12461805; rs34350172; rs3730983; rs35538558; rs28674712; rs3730953; rs34623721; rs28549163; rs10418941; rs3833254; rs3730906; rs12980617; rs35469253; rs12461815; rs10625177; rs34337010; rs12461807; rs41561716; rs3730979; rs8112003; rs35546700; rs34430179; rs3730904; rs35879428; rs10405578; rs3730923; rs35056937; rs34833018; rs4987073; rs3731033; rs3730962; rs3786758; rs3731017; rs3731018; rs34280126; rs34777443; rs3730929; rs35408335; rs34073314; rs34904322; rs3730928; rs4987072; rs34289915; rs3731041; rs3731031; rs3745736; rs41543521; rs36185366; rs274888; rs11444392; rs3730964; rs3730941; rs190656; rs274882; rs3730937; rs34576382; rs12975748; rs3730890; rs41562612; rs2386965; rs10714747; rs8100102; rs36027045; rs34969875; rs35048967; rs274894; rs3730893; rs10567824; rs3730935; rs34148826; rs415465; rs34407762; rs274890; rs3730984; rs3731028; rs35880585; rs35127581; rs393404; rs35844660; rs35858886; rs35879443; rs3730971; rs3730866; rs34423539; rs10415947; rs35526649; rs35384174; rs156642; rs28759107; rs3730907; rs3730930; rs10533938; rs41562116; rs10413642; rs274895; rs34884434; rs870232; rs35976022; rs5828335; rs41545337; rs3730957; rs274863; rs3730892; rs36171813; rs3730963; rs10603723; rs3730950; rs12981414; rs3731010; rs28453888; rs41540714; rs3730936; rs2082319; rs3730975; rs41555716; rs34642096; rs34510630; rs41563420; rs41541014; rs3730965; rs3731039; rs34909809; rs3760813; rs34811835; rs34134727; rs35986724; rs12974614; rs12104196; rs11353435; rs12979997; rs3731040; rs274887; rs35936540; rs3730916; rs35691497; rs34448490; rs34430602; rs3730896; rs274891; rs3730967; rs3730981; rs35212188; rs34430527; rs35813149; rs420981; rs34967871; rs35061464; rs34123451; rs5828334; rs34584742; rs10405655; rs10407902; rs10409906; rs10411910; rs11083918; rs11564498; rs12462020; rs1654377; rs251693; rs274866; rs274867; rs274869; rs274870; rs274871; rs274873; rs274875; rs274876; rs34472427; rs3729527; rs3730842; rs380359; rs7250148

# Metabolic_Enzyme_124_General_References:
2204063; 1881902; 1581963

# Metabolic_Enzyme_124_References:
Not Available

# Metabolic_Enzyme_125_ID:
5977

# Metabolic_Enzyme_125_Name:
Adenylate cyclase type 7

# Metabolic_Enzyme_125_Synonyms:
Adenylate cyclase type VII; ATP pyrophosphate-lyase 7; Adenylyl cyclase 7

# Metabolic_Enzyme_125_Gene_Name:
ADCY7

# Metabolic_Enzyme_125_Protein_Sequence:
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN


# Metabolic_Enzyme_125_Number_of_Residues:
1080

# Metabolic_Enzyme_125_Molecular_Weight:
120310

# Metabolic_Enzyme_125_Theoretical_pI:
8.16

# Metabolic_Enzyme_125_GO_Classification:
>>>
Function:  cyclase activity
Function:  adenylate cyclase activity
Function:  catalytic activity
Function:  lyase activity
Function:  phosphorus-oxygen lyase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide biosynthesis
Process:  cyclic nucleotide biosynthesis
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  intracellular signaling cascade
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_125_General_Function:
Signal transduction mechanisms 

# Metabolic_Enzyme_125_Specific_Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

# Metabolic_Enzyme_125_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_125_Reaction:
ATP = 3',5'-cyclic AMP + diphosphate

# Metabolic_Enzyme_125_Pfam_Domain_Function:
PF06327:DUF1053;
PF00211:Guanylate_cyc

# Metabolic_Enzyme_125_Signals:
None

# Metabolic_Enzyme_125_Transmembrane_Regions:
34-54
63-83
95-117
122-142
147-167
176-196
595-615
620-640
669-688
718-737
746-773
794-814

# Metabolic_Enzyme_125_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_125_EC_Link:
EC 4.6.1.1

# Metabolic_Enzyme_125_GenBank_ID_Protein:
40788941

# Metabolic_Enzyme_125_SwissProt_ID:
ADCY7_HUMAN (P51828)

# Metabolic_Enzyme_125_swissprot_Name:
Not Available

# Metabolic_Enzyme_125_Genecard_id:
ADCY7

# Metabolic_Enzyme_125_Geneatlas_id:
ADCY7

# Metabolic_Enzyme_125_hgnc_id:
HGNC:238

# Metabolic_Enzyme_125_PDB_ID:
Not Available

# Metabolic_Enzyme_125_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_125_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_125_Subcellular_Location:
Membrane; multi-pass membrane protein

# Metabolic_Enzyme_125_Gene_Sequence:
>3267 bp
CGACACGCGTGCCAAGGGTGGAGGATGCCAGCCAAGGGGCGCTACTTCCTCAACGAGGGC
GAGGAGGGCCCTGACCAAGATGCGCTCTACGAGAAGTACCAGCTCACCAGCCAGCATGGG
CCGCTGCTGCTCACGCTCCTGCTGGTGGCCGCCACTGCCTGCGTGGCCCTCATCATCATT
GCCTTCAGCCAGGGGGACCCCTCCAGACACCAGGCCATTCTGGGCATGGCGTTCCTGGTG
CTGGCGGTGTTTGCGGCCCTCTCTGTGCTGATGTACGTCGAGTGTCTCCTGCGGCGCTGG
CTCAGGGCCTTGGCGCTGCTCACCTGGGCCTGCTTGGTGGCGCTGGGCTATGTGCTGGTG
TTCGACGCATGGACAAAGGCGGCCTGTGCGTGGGAGCAGGTGCCCTTCTTCCTGTTCATT
GTCTTCGTGGTGTACACACTACTGCCCTTCAGCATGCGGGGCGCTGTCGCCGTTGGGGCC
GTCTCCACTGCCTCCCACCTCCTGGTGCTCGGTTCTTTGATGGGAGGCTTCACGACACCC
AGTGTCCGGGTGGGGCTGCAGCTGCTGGCCAACGCAGTCATCTTCCTGTGTGGGAACCTG
ACAGGCGCCTTCCACAAGCACCAAATGCAGGATGCGTCCCGGGACCTCTTCACCTACACT
GTGAAGTGCATCCAGATCCGCCGGAAGCTGCGCATCGAGAAGCGCCAGCAGGAGAACCTG
CTGCTGTCAGTGCTTCCGGCCCACATCTCCATGGGCATGAAGCTGGCCATCATCGAACGG
CTCAAGGAGCATGGTGACCGTCGCTGCATGCCTGACAACAACTTCCACAGCCTCTACGTC
AAGAGGCACCAGAATGTCAGCATCCTCTATGCGGACATCGTGGGCTTCACGCAGCTGGCC
AGCGACTGTTCTCCCAAGGAGCTGGTGGTGGTGCTGAATGAGCTCTTTGGCAAGTTCGAC
CAGATCGCCAAGGCCAACGAGTGCATGCGAATCAAGATCCTCGGCGACTGCTACTACTGT
GTATCGGGCCTGCCCGTGTCGCTGCCTACCCACGCCCGGAACTGCGTGAAGATGGGGCTG
GACATGTGCCAGGCCATCAAGCAGGTGCGGGAGGCCACGGGCGTGGACATCAACATGCGT
GTGGGCATACACTCGGGGAATGTGCTGTGCGGGGTCATCGGGCTGCGCAAGTGGCAGTAT
GACGTGTGGTCCCACGACGTGTCCCTGGCCAACCGGATGGAGGCAGCCGGAGTACCCGGC
CGGGTGCACATCACGGAGGCCACGCTAAAGCACCTGGACAAGGCGTACGAGGTGGAGGAT
GGGCACGGGCAGCAGCGGGACCCCTACCTCAAGGAGATGAACATCCGCACCTACCTGGTC
ATCGACCCCCGGAGCCAGCAGCCACCCCCGCCCAGCCAACACCTCCCCAGGCCCAAGGGG
GACGCGGCCCTGAAGATGCGGGCGTCAGTGCGCATGACCCGGTACCTCGAGTCCTGGGGG
GCGGCACGGCCCTTTGCACATCTCAACCACCGTGAGAGCGTGAGCAGTGGTGAGACCCAC
GTCCCCAACGGGCGGAGGCCTAAGAGCGTTCCCCAGCGCCACCGCCGGACCCCAGACAGA
AGCATGTCCCCCAAGGGGCGGTCGGAGGATGACTCGTACGATGACGAGATGCTGTCAGCC
ATTGAGGGGCTCAGCTCCACGAGGCCCTGCTGCTCCAAGTCCGATGACTTCTACACCTTT
GGGTCCATCTTCCTGGAGAAGGGCTTTGAGCGCGAGTACCGCCTGGCACCCATCCCCCGG
GCCCGCCACGACTTTGCCTGCGCCAGCCTGATCTTCGTCTGCATCCTGCTCGTCCATGTC
CTGCTCATGCCCAGGACGGCGGCACTGGGTGTGTCCTTCGGGCTGGTGGCCTGTGTACTG
GGGCTGGTGCTGGGCCTGTGCTTTGCCACCAAGTTCTCGAGGTGCTGCCCAGCTCGGGGG
ACGCTCTGCACTATCTCTGAGAGGGTGGAGACACAGCCCCTGCTGAGGCTGACCCTGGCC
GTCCTGACCATCGGCAGCCTGCTCACTGTGGCCATCATCAACCTGCCCCTGATGCCTTTC
CAAGTTCCAGAGCTGCCTGTTGGCAATGAGACAGGCCTACTGGCCGCGAGCAGCAAGACA
AGAGCCCTGTGTGAGCCCCTCCCGTACTACACCTGCAGCTGTGTCCTGGGCTTCATCGCC
TGCTCGGTCTTCCTGAGGATGAGCCTGGAGCCAAAGGTTGTGCTGCTGACAGTGGCCCTG
GTGGCCTACCTGGTGCTCTTCAACCTCTCCCCATGCTGGCAGTGGGACTGCTGCGGCCAA
GGCCTGGGCAACCTCACCAAGCCCAACGGCACCACCAGTGGCACCCCTAGCTGTTCCTGG
AAGGACCTGAAGACCATGACCAATTTCTACCTGGTCCTGTTCTACATCACCCTGCTTACA
CTCTCCAGACAGATTGACTATTACTGCCGCTTGGACTGCCTATGGAAGAAGAAGTTCAAG
AAGGAGCACGAGGAGTTTGAGACCATGGAGAACGTGAACCGCCTTCTTCTGGAGAACGTC
CTGCCAGCCCACGTGGCTGCCCACTTTATCGGTGACAAGTTAAACGAGGACTGGTACCAT
CAGTCCTATGACTGCGTCTGTGTCATGTTTGCCTCCGTGCCGGACTTCAAAGTGTTCTAC
ACAGAGTGCGATGTCAACAAAGAAGGGCTGGAGTGCCTACGCCTGCTCAATGAGATCATT
GCCGACTTCGACGAGCTCCTACTGAAGCCCAAGTTCAGCGGCGTGGAGAAGATCAAGACC
ATCGGCAGCACGTACATGGCAGCTGCAGGGCTCAGCGTCGCCTCAGGGCACGAGAACCAG
GAGCTGGAGCGGCAGCATGCCCACATTGGTGTCATGGTGGAGTTCAGCATCGCCCTGATG
AGTAAGCTGGACGGCATCAACAGGCACTCCTTCAACTCCTTCCGCCTCCGCGTCGGCATA
AACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCCCGAAAACCTCAGTATGACATCTGG
GGAAACACTGTCAATGTGGCCAGCCGAATGGAAAGCACTGGAGAACTTGGGAAAATCCAG
GTTACCGAGGAGACCTGCACCATCCTCCAGGGCCTCGGGTACTCTTGTGAATGCCGTGGC
CTGATCAACGTCAAAGGCAAAGGCGAGCTGAGGACTTACTTTGTCTGTACGGACACTGCC
AAGTTTCAGGGGCTGGGGCTGAACTGA

# Metabolic_Enzyme_125_GenBank_ID_Gene:
D25538

# Metabolic_Enzyme_125_Chromosome_Location:
Chromosome:16

# Metabolic_Enzyme_125_Locus:
16q12-q13

# Metabolic_Enzyme_125_SNPs:
rs17289102; rs11861332; rs1064448; rs1872691; rs11644926; rs1540624; rs2302681; rs8052384; rs9939322; rs4785211; rs9936021; rs4785403; rs8061123; rs9926131; rs7191958; rs4785210; rs4785402; rs3813755; rs729229; rs2302712; rs11649380; rs9924714; rs8045659; rs8049122; rs2302680; rs7193839; rs11648839; rs7193875; rs2302717; rs2302715; rs12445243; rs11859417; rs728962; rs2302716; rs11861597; rs7202127; rs7186882; rs12444679; rs8056293; rs3833062; rs2302679; rs9927261; rs8060642; rs4082435; rs3826173; rs3892156; rs3760012; rs3760011; rs28514808; rs7359472; rs2230664; rs1064447; rs8051594; rs35787328; rs10589177; rs9940992; rs4785407; rs12918980; rs12444266; rs7500891; rs5816686; rs35969283; rs34860956; rs34493825; rs9937781; rs35262781; rs2302678; rs13332825; rs12932721; rs34996336; rs2302714; rs11640409; rs12932722; rs16948389; rs34039653; rs28510819; rs28432797; rs3841348; rs3214383; rs3815562; rs35078746; rs34191947; rs11403746; rs4502213; rs34381393; rs7197662; rs35284914; rs28403987; rs2302713; rs12919306; rs35003370; rs35732926; rs35829985; rs34216705; rs11352304; rs10577557; rs12444236; rs12924307; rs12598249; rs11417859; rs12443620; rs8048743; rs34009001; rs34686094; rs8053067; rs1078151; rs11644043; rs11645133; rs11649621; rs11860192; rs17216076; rs1872688; rs34176129; rs3760013; rs3760014; rs4497684; rs4785401; rs4785408; rs7184476; rs7184802; rs7196135; rs7204026; rs751127; rs8046783; rs8057103; rs8061808; rs9922362; rs9926720; rs9937029; rs9940619

# Metabolic_Enzyme_125_General_References:
7584026

# Metabolic_Enzyme_125_References:
16413094; 16648610; 17008420

# Metabolic_Enzyme_126_ID:
8700

# Metabolic_Enzyme_126_Name:
Hypothetical protein DKFZp666F229

# Metabolic_Enzyme_126_Synonyms:
Not Available

# Metabolic_Enzyme_126_Gene_Name:
DKFZp666F229

# Metabolic_Enzyme_126_Protein_Sequence:
>Hypothetical protein DKFZp666F229
DDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLR
HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAV
EAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVV
KGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFI
MFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLAT
GAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTI
LSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMA
VEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRI
NPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFL
KMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKA
VEQGGAFSNPETLDLYRDIPELQGF

# Metabolic_Enzyme_126_Number_of_Residues:
625

# Metabolic_Enzyme_126_Molecular_Weight:
69801

# Metabolic_Enzyme_126_Theoretical_pI:
6.37

# Metabolic_Enzyme_126_GO_Classification:
>>>
 Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-sulfur bonds
Function:  CoA-ligase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  isoprenoid metabolism
Process:  isoprenoid biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_126_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_126_Specific_Function:
Not Available

# Metabolic_Enzyme_126_Pathway:
Not Available

# Metabolic_Enzyme_126_Reaction:
Not Available

# Metabolic_Enzyme_126_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_126_Signals:
1-303

# Metabolic_Enzyme_126_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_126_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_126_EC_Link:
EC 6.2.1.16

# Metabolic_Enzyme_126_GenBank_ID_Protein:
52545788

# Metabolic_Enzyme_126_SwissProt_ID:
Q658Q8_HUMAN (Q658Q8)

# Metabolic_Enzyme_126_swissprot_Name:
Not Available

# Metabolic_Enzyme_126_Genecard_id:
DKFZp666F229

# Metabolic_Enzyme_126_Geneatlas_id:
DKFZp666F229

# Metabolic_Enzyme_126_hgnc_id:
HGNC:21298

# Metabolic_Enzyme_126_PDB_ID:
Not Available

# Metabolic_Enzyme_126_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_126_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_126_Subcellular_Location:
Not Available

# Metabolic_Enzyme_126_Gene_Sequence:
>1878 bp
GATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGACTTCTGGGCAGAGTTCTGGAAA
TTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTTGTGGACACATCGAAAGGAATC
GCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAACTATGCAGAAAACCTCCTGCGG
CACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGGGAAGGCAAAGAGGAAATTGTG
AAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTGTTTGCAGCAGCAATGAGGAAA
ATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTACCCAACAGTGAGCACGCTGTC
GAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGGAGCTCCACGTCCCCGGACTTC
GGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAGCCAAAGCTCATCTTCTCTGTG
GAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATGGAAAAGCTGCAGCAGGTGGTT
AAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCTTATGTGTCCTCCAGAGAGAAC
ATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGATGACTTTCTTGCCACCGGCACC
AGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCCTTCAGCCACCCACTGTTCATC
ATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATGGTGCATTCCGCTGGGGGCACC
CTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAACATGACCAGCAGTGACATCCTC
CTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGGATGGTGTCCCTTCTGGCCACA
GGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTGCCCACGCCCAATGTGCTCTGG
GACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACTGGGGCCAAGTGGCTGTCAGTG
CTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGTCTCCAGATGCTCCACACGATC
CTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAGTATGTCTACAGGTGCATCAAG
AGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGACATCATCTCCTGCTTCATGGGC
CACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAGGCCCGGAACCTGGGCATGGCC
GTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGAGAGAGCGGCGAGCTGGTGTGT
ACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAACGATGAGAACGGCAACAAGTAC
AGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCTCATGGCGACTACTGCAGAATC
AACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGTGACGGCACCCTCAACCCCAAC
GGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTGGAATCCTTCGAGGAGGTGGAG
GACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAGGAGAGGGTGATCCTCTTCCTG
AAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTTAAGAGGATCCGTGACGCCATC
CGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATCCTGGAAACCAAGGGCATCCCG
TATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAACAGATCATCGCTGGAAAAGCC
GTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTGGATCTGTACCGGGACATCCCT
GAGCTGCAGGGCTTCTGA

# Metabolic_Enzyme_126_GenBank_ID_Gene:
AL833047

# Metabolic_Enzyme_126_Chromosome_Location:
Not Available

# Metabolic_Enzyme_126_Locus:
Not Available

# Metabolic_Enzyme_126_SNPs:
Not Available

# Metabolic_Enzyme_126_General_References:
Not Available

# Metabolic_Enzyme_126_References:
Not Available

# Metabolic_Enzyme_127_ID:
8813

# Metabolic_Enzyme_127_Name:
Glutamine-dependent NAD(+) synthetase

# Metabolic_Enzyme_127_Synonyms:
NAD(+synthase [glutamine-hydrolyzing]; NAD(+synthetase 1

# Metabolic_Enzyme_127_Gene_Name:
NADSYN1

# Metabolic_Enzyme_127_Protein_Sequence:
>Glutaminedependent NAD+ synthetase
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHHVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD

# Metabolic_Enzyme_127_Number_of_Residues:
706

# Metabolic_Enzyme_127_Molecular_Weight:
79295

# Metabolic_Enzyme_127_Theoretical_pI:
6.46

# Metabolic_Enzyme_127_GO_Classification:
>>>
 Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Function:  NAD+ synthase (glutamine-hydrolyzing) activity
 ||
>>>
 Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  cofactor metabolism
Process:  coenzyme metabolism
Process:  coenzyme biosynthesis
Process:  pyridine nucleotide biosynthesis
Process:  NAD biosynthesis
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_127_General_Function:
Coenzyme transport and metabolism

# Metabolic_Enzyme_127_Specific_Function:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

# Metabolic_Enzyme_127_Pathway:
map00251  Glutamate metabolism
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_127_Reaction:
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate

# Metabolic_Enzyme_127_Pfam_Domain_Function:
PF00795:CN_hydrolase
PF02540:NAD_synthase

# Metabolic_Enzyme_127_Signals:
Not Available

# Metabolic_Enzyme_127_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_127_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_127_EC_Link:
EC 6.3.5.1

# Metabolic_Enzyme_127_GenBank_ID_Protein:
Not Available

# Metabolic_Enzyme_127_SwissProt_ID:
NADE1_HUMAN (Q6IA69)

# Metabolic_Enzyme_127_swissprot_Name:
Not Available

# Metabolic_Enzyme_127_Genecard_id:
NADSYN1

# Metabolic_Enzyme_127_Geneatlas_id:
NADSYN1

# Metabolic_Enzyme_127_hgnc_id:
HGNC:29832

# Metabolic_Enzyme_127_PDB_ID:
Not Available

# Metabolic_Enzyme_127_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_127_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_127_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_127_Gene_Sequence:
Not Available

# Metabolic_Enzyme_127_GenBank_ID_Gene:
AB091316

# Metabolic_Enzyme_127_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_127_Locus:
11q13.4

# Metabolic_Enzyme_127_SNPs:
rs2276360; rs7121106; rs12282060; rs35007971; rs2186778; rs2276354; rs11540018; rs1792226; rs4944957; rs732934; rs1792231; rs1540127; rs1790340; rs4402322; rs3794064; rs1893058; rs1792227; rs1790341; rs4944997; rs7129044; rs4944958; rs3814734; rs3814731; rs4944959; rs1792225; rs1790373; rs4944075; rs3794060; rs2017686; rs2276358; rs1792224; rs1790344; rs4423214; rs949178; rs1790339; rs1792316; rs4944955; rs1792229; rs2276361; rs4435028; rs1790343; rs2040323; rs4616066; rs4944956; rs1619577; rs3794062; rs3794057; rs1792235; rs7114525; rs2276362; rs3814733; rs12575605; rs2298776; rs3794067; rs7938885; rs1629220; rs3794061; rs12577807; rs10898203; rs3819215; rs11600569; rs1792234; rs6592154; rs7129099; rs12800438; rs10898210; rs12574206; rs4944076; rs3794065; rs10898193; rs4944998; rs3794068; rs2276353; rs7952035; rs3794059; rs12277408; rs4944062; rs2282619; rs12575622; rs10898211; rs7944926; rs7120029; rs7935125; rs2282618; rs12286616; rs11233747; rs12576621; rs3831470; rs7950778; rs2298773; rs12281892; rs7123973; rs4944979; rs10898191; rs12295554; rs12274363; rs7948770; rs2282617; rs3814732; rs11600355; rs7130038; rs7948898; rs2298772; rs12790558; rs10160536; rs12270619; rs7114825; rs1792319; rs12792306; rs3829251; rs12808368; rs10160376; rs1792315; rs11233789; rs12273154; rs7131218; rs41395047; rs1792233; rs11602942; rs4944063; rs4488226; rs7949129; rs7129788; rs11233901; rs4944999; rs12286569; rs3794063; rs3838792; rs11233754; rs2282620; rs12286997; rs10898201; rs1629304; rs10898186; rs2298775; rs3794066; rs11233746; rs12278461; rs12285168; rs3819214; rs12807718; rs2282621; rs3763860; rs7130479; rs12275636; rs12280406; rs4944064; rs12574554; rs10898200; rs11233933; rs4944996; rs12280295; rs12288906; rs12785878; rs751389; rs2002064; rs11546509; rs11600860; rs11606611; rs2002063; rs11606631; rs11606612; rs7950441; rs35588716; rs35279643; rs3192486; rs34989018; rs12282141; rs12791871; rs10466717; rs7117435; rs11233810; rs11233800; rs4414250; rs34354702; rs35349037; rs35043114; rs11233896; rs7950697; rs7123872; rs35799712; rs35611530; rs12795432; rs35482873; rs34432098; rs7117446; rs35741576; rs10625411; rs12795438; rs12275635; rs12792622; rs7943296; rs12269986; rs34316417; rs35072948; rs11233744; rs11354381; rs2298774; rs12793224; rs1123007; rs3838794; rs12285566; rs2276357; rs7120978; rs12793235; rs10751102; rs11825517; rs1894101; rs35877645; rs34693567; rs12806844; rs7938224; rs28823295; rs7130315; rs10717036; rs2511010; rs10667241; rs12284909; rs28722015; rs11451410; rs3838793; rs7947153; rs34147368; rs35670335; rs12800594; rs1790342; rs34130258; rs12790010; rs35262706; rs12275637; rs11820509; rs35809668; rs35106262; rs3763859; rs36007316; rs35713855; rs11233919; rs10160252; rs11233871; rs34587279; rs10466698; rs12800580; rs2276359; rs35816375; rs12793040; rs7946818; rs12274022; rs34267425; rs12225516; rs34448346; rs34566508; rs11233750; rs35149281; rs11233897; rs12224205; rs2276355; rs12289358; rs1052193; rs7113783; rs7114971; rs753352; rs28898287; rs34753851; rs12794668; rs732935; rs7107444; rs35150568; rs5792561; rs34591259; rs11607157; rs11233902; rs34864556; rs35880452; rs12794647; rs12789751; rs34966057; rs12278475; rs36056023; rs11233868; rs12807827; rs1626291; rs35865105; rs11233947; rs1002171; rs1044482; rs10792743; rs10898223; rs11233977; rs11823940; rs11824413; rs12283114; rs12283185; rs12283407; rs12289036; rs12289074; rs12360674; rs12422045; rs12573951; rs17161531; rs17161576; rs1790334; rs2155425; rs2155428; rs2186777; rs2851691; rs2851692; rs2851693; rs3750997; rs4245442; rs4316537; rs4944946; rs4944949; rs4945007; rs4945008; rs7926054; rs7928249; rs7940244; rs7950584; rs7950649

# Metabolic_Enzyme_127_General_References:
12547821

# Metabolic_Enzyme_127_References:
Not Available

# Metabolic_Enzyme_128_ID:
8856

# Metabolic_Enzyme_128_Name:
Gene with similarity to rat kidney-specific

# Metabolic_Enzyme_128_Synonyms:
KSgene

# Metabolic_Enzyme_128_Gene_Name:
A-923A4.2

# Metabolic_Enzyme_128_Protein_Sequence:
>Gene with similarity to rat kidneyspecific
MKIKPGFMGKATPPYDVQFHMEASVENCIIVSMNTADPGSQGITHSLLLQVIDDKGSILP
PNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSD
DIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQL
TKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM

# Metabolic_Enzyme_128_Number_of_Residues:
228

# Metabolic_Enzyme_128_Molecular_Weight:
25153

# Metabolic_Enzyme_128_Theoretical_pI:
6.04

# Metabolic_Enzyme_128_GO_Classification:
>>>
 Function:  catalytic activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_128_General_Function:
Lipid transport and metabolism

# Metabolic_Enzyme_128_Specific_Function:
Not Available

# Metabolic_Enzyme_128_Pathway:
Not Available

# Metabolic_Enzyme_128_Reaction:
Not Available

# Metabolic_Enzyme_128_Pfam_Domain_Function:
PF00501:AMP-binding

# Metabolic_Enzyme_128_Signals:
Not Available

# Metabolic_Enzyme_128_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_128_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_128_EC_Link:
EC 6.2.1.2

# Metabolic_Enzyme_128_GenBank_ID_Protein:
3219339

# Metabolic_Enzyme_128_SwissProt_ID:
O75203_HUMAN (O75203)

# Metabolic_Enzyme_128_swissprot_Name:
Not Available

# Metabolic_Enzyme_128_Genecard_id:
A-923A4.2

# Metabolic_Enzyme_128_Geneatlas_id:
A-923A4.2

# Metabolic_Enzyme_128_hgnc_id:
HGNC:18049

# Metabolic_Enzyme_128_PDB_ID:
Not Available

# Metabolic_Enzyme_128_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_128_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_128_Subcellular_Location:
Not Available

# Metabolic_Enzyme_128_Gene_Sequence:
>687 bp
ATGAAGATCAAGCCGGGTTTCATGGGGAAGGCCACTCCACCCTATGACGTCCAGTTTCAT
ATGGAGGCCTCAGTTGAAAACTGCATTATTGTGAGCATGAACACCGCTGACCCTGGCAGC
CAGGGCATCACACACAGCCTCTTGCTACAGGTCATTGATGACAAGGGCAGCATCCTGCCA
CCTAACACAGAAGGAAACATTGGCATCAGAATCAAACCTGTCAGGCCTGTGAGCCTCTTC
ATGTGCTATGAGGGTGACCCAGAGAAGACAGCTAAAGTGGAATGTGGGGACTTCTACAAC
ACTGGGGACAGAGGAAAGATGGATGAAGAGGGCTACATTTGTTTCCTGGGGAGGAGTGAT
GACATCATTAATGCCTCTGGGTATCGCATCGGGCCTGCAGAGGTTGAAAGCGCTTTGGTG
GAGCACCCAGCGGTGGCGGAGTCAGCCGTGGTGGGCAGCCCAGACCCGATTCGAGGGGAG
GTGGTGAAGGCCTTTATTGTCCTGACCCCACAGTTCCTGTCCCATGACAAGGATCAGCTG
ACCAAGGAACTGCAGCAGCATGTCAAGTCAGTGACAGCCCCATACAAGTACCCAAGGAAG
GTGGAGTTTGTCTCAGAGCTGCCAAAAACCATCACTGGCAAGATTGAACGGAAGGAACTT
CGGAAAAAGGAGACTGGTCAGATGTAA

# Metabolic_Enzyme_128_GenBank_ID_Gene:
AC003034

# Metabolic_Enzyme_128_Chromosome_Location:
Not Available

# Metabolic_Enzyme_128_Locus:
Not Available

# Metabolic_Enzyme_128_SNPs:
Not Available

# Metabolic_Enzyme_128_General_References:
10493829

# Metabolic_Enzyme_128_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
5835

# Macromolecular_Interacting_Partner_1_Name:
NEDD8-conjugating enzyme Ubc12

# Macromolecular_Interacting_Partner_1_Synonyms:
Ubiquitin-conjugating enzyme E2 M; NEDD8 protein ligase; NEDD8 carrier protein

# Macromolecular_Interacting_Partner_1_Gene_Name:
UBE2M

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>NEDD8conjugating enzyme Ubc12
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
183

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
20900

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.84

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Accepts the ubiquitin-like protein NEDD8 from the UBE1C- APPBP1 E1 complex and catalyzes its covalent attachment to other proteins. Involved in cell proliferation

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00179:UQ_con

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
3599674

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
UBC12_HUMAN (P61081)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
UBE2M

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
UBE2M

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:12491

# Macromolecular_Interacting_Partner_1_PDB_ID:
1Y8X

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>552 bp
ATGATCAAGCTGTTCTCGCTGAAGCAGCAGAAGAAGGAGGAGGAGTCGGCGGGCGGCACC
AAGGGCAGCAGCAAGAAGGCGTCGGCGGCGCAGCTGCGGATCCAGAAGGACATAAACGAG
CTGAACCTGCCCAAGACGTGTGATATCAGCTTCTCAGATCCAGACGACCTCCTCAACTTC
AAGCTGGTCATCTGTCCTGATGAGGGCTTCTACAAGAGTGGGAAGTTTGTGTTCAGTTTT
AAGGTGGGCCAGGGTTACCCGCATGATCCCCCCAAGGTGAAGTGTGAGACAATGGTCTAT
CACCCCAACATTGACCTCGAGGGCAACGTCTGCCTCAACATCCTCAGAGAGGACTGGAAG
CCAGTCCTTACGATAAACTCCATAATTTATGGCCTGCAGTATCTCTTCTTGGAGCCCAAC
CCCGAGGACCCACTGAACAAGGAGGCCGCAGAGGTCCTGCAGAACAACCGGCGGCTGTTT
GAGCAGAACGTGCAGCGCTCCATGCGGGGTGGCTACATCGGCTCCACCTACTTTGAGCGC
TGCCTGAAATAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB012191

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.43

# Macromolecular_Interacting_Partner_1_SNPs:
Not Available

# Macromolecular_Interacting_Partner_1_General_References:
9694792; 10207026; 10828074

# Macromolecular_Interacting_Partner_1_References:
Not Available

# Macromolecular_Interacting_Partner_2_ID:
5866

# Macromolecular_Interacting_Partner_2_Name:
RNA 3'-terminal phosphate cyclase-like protein

# Macromolecular_Interacting_Partner_2_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_2_Gene_Name:
RCL1

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>RNA 3'terminal phosphate cyclaselike protein
MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITN
GSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGV
TNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPI
QLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPG
FGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSL
ALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTC
VGIGFSNLSKTLK

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
373

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
40843

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
9.67

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  cyclase activity
Function:  RNA-3'-phosphate cyclase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_2_General_Function:
RNA processing and modification 

# Macromolecular_Interacting_Partner_2_Specific_Function:
Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF01137:RTC;
PF05189:RTC_insert

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
7688192

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
RCL1_HUMAN (Q9Y2P8)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
RCL1

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
RCL1

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:17687

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Nucleus; nucleolus

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>1122 bp
ATGGCGACTCAGGCGCACTCCCTCAGCTACGCAGGGTGCAACTTCTTGCGCCAACGTCTG
GTCCTGTCTACCCTGAGCGGGCGCCCCGTCAAAATCCGAAAGATTCGGGCCAGAGACGAC
AACCCGGGCCTCCGAGATTTTGAAGCCAGCTTCATAAGGCTATTGGACAAAATAACGAAT
GGTTCTCGAATTGAAATAAACCAAACAGGAACAACCTTATATTATCAGCCTGGCCTCCTG
TATGGTGGATCTGTGGAACATGACTGTAGCGTCCTTCGTGGCATTGGGTATTACCTGGAG
AGTCTTCTTTGCTTGGCTCCATTTATGAAGCACCCGTTAAAAATAGTTCTACGAGGAGTG
ACCAATGATCAGGTTGACCCTTCAGTTGATGTTCTTAAGGCAACAGCACTCCCTTTGTTG
AAACAATTTGGGATTGATGGTGAATCATTTGAACTGAAGATTGTGCGACGGGGAATGCCT
CCCGGAGGAGGAGGCGAAGTGGTTTTCTCATGTCCTGTGAGGAAGGTCTTGAAGCCCATT
CAACTCACAGATCCAGGAAAAATCAAACGTATTAGAGGAATGGCGTACTCTGTACGTGTG
TCACCTCAGATGGCGAACCGGATTGTGGATTCTGCAAGGAGCATCCTCAACAAGTTCATA
CCTGATATCTATATTTACACAGATCACATGAAAGGAGTCAACTCTGGGAAGTCTCCGGGC
TTTGGGTTGTCACTGGTTGCTGAGACCACCAGTGGCACCTTCCTCAGTGCTGAACTGGCC
TCCAACCCCCAGGGCCAGGGAGCAGCAGTACTTCCAGAGGACCTTGGCAGGAACTGTGCC
CGGCTGCTGCTGGAGGAAATCTACAGGGGTGGATGCGTAGACTCGACCAACCAAAGCCTG
GCGCTACTACTCATGACCCTTGGACAGCGGGATGTTTCCAAAGTCCTGCTAGGCCCTCTC
TCTCCCTACACGATAGAATTTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAA
ATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATGACCTGT
GTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
AJ276894

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_2_Locus:
Not Available

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
10790377; 11042152

# Macromolecular_Interacting_Partner_2_References:
Not Available

# Macromolecular_Interacting_Partner_3_ID:
5907

# Macromolecular_Interacting_Partner_3_Name:
SUMO-conjugating enzyme UBC9

# Macromolecular_Interacting_Partner_3_Synonyms:
SUMO-protein ligase; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; Ubiquitin carrier protein I; Ubiquitin carrier protein 9; p18

# Macromolecular_Interacting_Partner_3_Gene_Name:
UBE2I

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>SUMOconjugating enzyme UBC9
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
158

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
18007

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
8.90

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  small protein activating enzyme activity
Function:  ubiquitin-like activating enzyme activity
 ||
>>>
Process:  ubiquitin cycle
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00179:UQ_con

# Macromolecular_Interacting_Partner_3_Signals:
None

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
1296801

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
UBC9_HUMAN (P63279)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
UBE2I

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
UBE2I

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:12485

# Macromolecular_Interacting_Partner_3_PDB_ID:
1KPS

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>477 bp
ATGTCGGGGATCGCCCTCAGCAGACTCGCCCAGGAGAGGAAAGCATGGAGGAAAGACCAC
CCATTTGGTTTCGTGGCTGTCCCAACAAAAAATCCCGATGGCACGATGAACCTCATGAAC
TGGGAGTGCGCCATTCCAGGAAAGAAAGGGACTCCGTGGGAAGGAGGCTTGTTTAAACTA
CGGATGCTTTTCAAAGATGATTATCCATCTTCGCCACCAAAATGTAAATTCGAACCACCA
TTATTTCACCCGAATGTGTACCCTTCGGGGACAGTGTGCCTGTCCATCTTAGAGGAGGAC
AAGGACTGGAGGCCAGCCATCACAATCAAACAGATCCTATTAGGAATACAGGAACTTCTA
AATGAACCAAATATCCAAGACCCAGCTCAAGCAGAGGCCTACACGATTTACTGCCAAAAC
AGAGTGGAGTACGAGAAAAGGGTCCGAGCACAAGCCAAGAAGTTTGCGCCCTCATAA

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X96427

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:16

# Macromolecular_Interacting_Partner_3_Locus:
16p13.3

# Macromolecular_Interacting_Partner_3_SNPs:
rs3169412; rs8063; rs8047332; rs7302; rs6600134; rs9926183; rs9597; rs8062854; rs9926094; rs6600135; rs8062881; rs12102342; rs2268049; rs8052688; rs4017713; rs12446893; rs8053875; rs4017714; rs11248866; rs2281226; rs2369842; rs761060; rs761058; rs761059; rs4984806; rs8062227; rs4017786; rs4984808; rs909916; rs2369700; rs909915; rs8058975; rs909917; rs8046527; rs12447051; rs11648216; rs8063596; rs17135320; rs7202125; rs8045459; rs8063770; rs8044721; rs11648215; rs11647760; rs4984809; rs11248868; rs9933497; rs11648562; rs8043720; rs2235633; rs8050313; rs9328917; rs11645809; rs11644706; rs11553473; rs2281225; rs11553471; rs2230152; rs8060742; rs11553472; rs8057293; rs8053263; rs4984805; rs35636012; rs34122288; rs12102374; rs33974350; rs8046903; rs5815088; rs10547297; rs12926261; rs35840411; rs8062442; rs8056919; rs10903004; rs12129; rs1575040; rs12920764; rs4638578; rs12103099; rs7198283; rs9928135; rs34689784; rs9673771; rs3078791; rs28631092; rs909919; rs5815089; rs8048776; rs34122945; rs35756062; rs7186045; rs11321641; rs4984807; rs8051743; rs35143301; rs28510571; rs33913982; rs11643527; rs9941160; rs7190309; rs28867488; rs34139034; rs909918; rs4984810; rs12927902; rs11248867; rs8046847; rs11274233; rs12449104; rs7195339; rs8060456; rs34839745; rs10677849; rs12927901; rs34342091; rs12918274; rs33983021; rs12444610; rs2982430; rs28457180; rs2974842; rs28971051; rs2974843; rs12933428; rs12930585; rs2982429; rs1061614; rs1061619; rs1061621; rs1061633; rs11248865; rs12925270; rs1883561; rs34250044; rs35702607; rs3759936; rs3759937; rs4261539; rs4984803; rs4984804; rs4984811; rs4984813; rs6600128; rs6600129; rs710902; rs7187167; rs7195012; rs7204003; rs731046; rs761061; rs761062; rs761063; rs761064; rs8048759; rs909914

# Macromolecular_Interacting_Partner_3_General_References:
8668529; 9067428; 8565643; 8668125; 8798754; 9333025; 11157797; 8824223; 9334332; 9261152

# Macromolecular_Interacting_Partner_3_References:
Not Available

# Macromolecular_Interacting_Partner_4_ID:
7549

# Macromolecular_Interacting_Partner_4_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_4_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_4_Gene_Name:
INS

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_4_Signals:
1-24

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
INS

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_4_Locus:
11p15.5

# Macromolecular_Interacting_Partner_4_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_4_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_4_References:
15930957

# Macromolecular_Interacting_Partner_5_ID:
7551

# Macromolecular_Interacting_Partner_5_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_5_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_5_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_5_Signals:
None

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_5_Locus:
6p21.3

# Macromolecular_Interacting_Partner_5_SNPs:
Not Available

# Macromolecular_Interacting_Partner_5_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_5_References:
16357326; 16419651

# Macromolecular_Interacting_Partner_6_ID:
7615

# Macromolecular_Interacting_Partner_6_Name:
cAMP response element-binding protein

# Macromolecular_Interacting_Partner_6_Synonyms:
CREB

# Macromolecular_Interacting_Partner_6_Gene_Name:
CREB1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>cAMP response elementbinding protein
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
341

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
36688

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
5.24

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  protein binding
Function:  transcription factor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00170:bZIP_1;
PF02173:pKID

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
240429

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
CREB1_HUMAN (P16220)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
CREB1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
CREB1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:2345

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>984 bp
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S72459

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_6_Locus:
2q34

# Macromolecular_Interacting_Partner_6_SNPs:
rs2709357; rs2709356; rs889895; rs2551917; rs2709400; rs2551640; rs2709360; rs2042486; rs2551642; rs4675682; rs2709359; rs2551639; rs11883511; rs7590024; rs2709355; rs2551641; rs2709398; rs2360970; rs2042485; rs12466352; rs2709399; rs2709387; rs2551920; rs2551923; rs2464978; rs6740584; rs2254137; rs2551921; rs2551919; rs9679258; rs9288383; rs3770704; rs13397461; rs12694087; rs2551922; rs16839883; rs2194430; rs11904814; rs2709393; rs3730300; rs2247053; rs10199872; rs2551924; rs2551644; rs2059336; rs17811997; rs7603049; rs11692041; rs7570673; rs3730276; rs13393250; rs2551645; rs2709402; rs2709388; rs2464977; rs17515722; rs2551926; rs13398837; rs10932201; rs2952766; rs12477957; rs2709392; rs2464976; rs2551638; rs35349697; rs34884247; rs35342276; rs12992351; rs12467170; rs13422727; rs13016095; rs10561230; rs10202862; rs35952037; rs35924297; rs35303892; rs3836057; rs1050641; rs2709354; rs35153918; rs4024317; rs35539388; rs11356093; rs12998737; rs11397523; rs35506841; rs9677382; rs35379208; rs12992752; rs12470697; rs13029939; rs12467171; rs13422622; rs35711096; rs35714520; rs34172985; rs10598911; rs4024318; rs35004775; rs3836058; rs10568689; rs13422714; rs35282925; rs35047346; rs34797824; rs7582473; rs35896795; rs6729764; rs12614101; rs7603975; rs2709385; rs13018430; rs34411431; rs2709403; rs34628133; rs2551647; rs7589804; rs34775277; rs35762508; rs2551646; rs28853093; rs17515729; rs13431009; rs2551918; rs7558859; rs34583259; rs2551648; rs34550164; rs2551925; rs6715664; rs2709404; rs35735523; rs7576411; rs4101544; rs34903544; rs3951781; rs34242417; rs1064176; rs4675684; rs6705627; rs11311967; rs13412269; rs34309640; rs10185283; rs11684107; rs36108540; rs35955521; rs5838079; rs35019306; rs35728983; rs2709389; rs34275460; rs34379142; rs2709362; rs35000643; rs35261053; rs35119018; rs13409275; rs2709381; rs34177886; rs12478868; rs34145676; rs2709378; rs2551643; rs7588606; rs34127936; rs35865443; rs12998128; rs2709377; rs11319861; rs11335782; rs35907148; rs34317727; rs35318842; rs1045780; rs1045790; rs12999688; rs13029936; rs13386109; rs1806584; rs1806585; rs2551928; rs2551931; rs2709371; rs2709373; rs2709374; rs2709376; rs2709396; rs6785; rs7569963

# Macromolecular_Interacting_Partner_6_General_References:
2142528; 2196176; 1966745; 2974179; 1831258; 8381074; 7608156

# Macromolecular_Interacting_Partner_6_References:
16143450; 16164634; 16234845; 16240350

# Macromolecular_Interacting_Partner_7_ID:
8405

# Macromolecular_Interacting_Partner_7_Name:
Hypothetical protein

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Hypothetical protein
MLFKAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALK
LLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKKRLAQLYRQTVCLSLLWRIY
SYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAM
EHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSL
CRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEEC
LEFIHQYENNRILKFHSGLLLGLYSSVAIWECEAGVGRRLHTSRDPGMPDFRNGTTFTNF
PIELKIFCQEEP

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
372

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
43901

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.26

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
EC 4.6.1.1

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
4153951

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
O95558_HUMAN (O95558)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
Not Available

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
Not Available

# Macromolecular_Interacting_Partner_7_hgnc_id:
Not Available

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>1119 bp
ATGCTGTTCAAGGCATACATGTATTTGAATGAAGGACAGAAGTTGCTAAAAACTCTCAAG
AAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTTTACAGCCTCAAAGGTGAG
GTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATGCTGAGGAAGGCACTGAAG
CTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTTCTCCATATCCATGTCGAG
AAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAGAGCCCACCTCCAGGGAAG
AAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCCTTGCTGTGGCGCATCTAT
AGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTGGCAGTTATGATGCAAATG
AATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAGGCTTACCTAGACTATTCG
CTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAATATGAAGTCATGGCCATG
GAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAAATCGTGGCATACGTGGCT
GAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGATTTGGCCATTGAGTTAGGC
TCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAACCGACATTATCAGTCCCTC
TGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCGCAATTGATCCAGGTGCTG
GGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTCAGCAAGGCATTTTTCTAT
TTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTATAGAACATTTGAAGAATGT
TTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAGTTCCACAGTGGACTCCTC
CTGGGACTTTATTCCTCTGTAGCTATCTGGGAGTGTGAAGCAGGGGTAGGCAGGAGACTA
CACACTTCCAGAGACCCAGGTATGCCAGACTTCAGGAATGGGACAACTTTTACAAATTTT
CCAATAGAGCTAAAAATCTTTTGCCAAGAAGAACCATGA

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
AL035122

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_7_Locus:
Not Available

# Macromolecular_Interacting_Partner_7_SNPs:
Not Available

# Macromolecular_Interacting_Partner_7_General_References:
Not Available

# Macromolecular_Interacting_Partner_7_References:
16098598; 16517146; 16527269

# Macromolecular_Interacting_Partner_8_ID:
7839

# Macromolecular_Interacting_Partner_8_Name:
5'-AMP-activated protein kinase subunit beta-1

# Macromolecular_Interacting_Partner_8_Synonyms:
AMPK beta-1 chain; AMPKb

# Macromolecular_Interacting_Partner_8_Gene_Name:
PRKAB1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>5'AMPactivated protein kinase subunit beta1
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
270

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
30383

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
6.37

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF04739:AMPKBI;
PF02922:Isoamylase_N

# Macromolecular_Interacting_Partner_8_Signals:
None

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
2916800

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
AAKB1_HUMAN (Q9Y478)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
PRKAB1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
PRKAB1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:9378

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Cytoplasmic

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>813 bp
ATGGGCAATACCAGCAGTGAGAGGGCGGCGCTGGAGCGGCATGCTGGCCATAAGACGCCC
CGGAGGGACAGCTCGGGGGGCACCAAGGACGGGGACAGGCCCAAGATCCTGATGGACAGC
CCCGAAGACGCCGACCTCTTCCACTCCGAGGAAATCAAGGCACCAGAGAAGGAGGAATTC
CTGGCCTGGCAGCATGATCTGGAAGTGAATGATAAAGCTCCCGCCCAGGCTCGGCCAACG
GTGTTTCGATGGACGGGGGGCGGAAAGGAAGTTTACTTATCTGGGTCCTTCAACAACTGG
AGTAAACTTCCCCTCACCAGAAGCCACAATAACTTTGTAGCCATCCTGGATCTGCCGGAA
GGAGAGCATCAGTACAAGTTCTTTGTGGATGGTCAGTGGACGCACGACCCTTCCGAGCCC
ATAGTAACCAGCCAGCTTGGCACAGTTAACAACATAATTCAAGTGAAGAAAACTGACTTT
GAGGTATTTGATGCTTTAATGGTGGATTCCCAAAAGTGCTCCGATGTGTCTGAGCTGTCC
AGTTCTCCCCCAGGACCCTACCATCAGGAGCCCTACGTCTGCAAACCCGAAGAGCGCTTT
CGGGCACCCCCTATTCTCCCCCCACATCTCCTCCAGGTCATCCTGAACAAGGACACGGGG
ATTTCCTGTGATCCAGCTTTGCTTCCTGAGCCCAATCACGTCATGCTGAACCACCTATAC
GCGCTGTCTATCAAGGATGGAGTGATGGTGCTCAGCGCAACCCACCGGTACAAGAAGAAG
TACGTCACCACCTTGTTATACAAGCCCATATGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AJ224515

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_8_Locus:
12q24.1

# Macromolecular_Interacting_Partner_8_SNPs:
rs4213; rs278148; rs278147; rs278149; rs278152; rs278143; rs6490267; rs278144; rs278145; rs10849690; rs17408578; rs278151; rs12314027; rs12304635; rs6490266; rs3759400; rs6490265; rs11064873; rs11546695; rs1043354; rs1062688; rs1043350; rs1043352; rs11064876; rs3182909; rs35934503; rs278146; rs278150; rs34309696; rs7312687; rs3999587; rs34549847; rs2285593; rs11832628; rs11064874; rs7953470; rs11064875; rs34516378; rs35524914; rs34062789; rs10774512; rs11064877; rs12305216; rs12425960; rs175878; rs1978107; rs1978108; rs2393550; rs278122; rs278123; rs278155; rs3742046; rs3930004; rs7300583; rs7310266; rs7953776; rs7960723

# Macromolecular_Interacting_Partner_8_General_References:
9224708

# Macromolecular_Interacting_Partner_8_References:
16151020; 16308421; 16434692; 16513051

# Macromolecular_Interacting_Partner_9_ID:
8529

# Macromolecular_Interacting_Partner_9_Name:
Novel protein

# Macromolecular_Interacting_Partner_9_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Name:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Novel protein
MFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLE
TDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEE
KIVDNLQSRHTAFIGDRN

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
138

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
15645

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
5.71

# Macromolecular_Interacting_Partner_9_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_9_General_Function:
Coenzyme transport and metabolism

# Macromolecular_Interacting_Partner_9_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF04127:DFP

# Macromolecular_Interacting_Partner_9_Signals:
Not Available

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
55665116

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
Q5VVM0_HUMAN (Q5VVM0)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
RP11-163G10.1

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:25686

# Macromolecular_Interacting_Partner_9_PDB_ID:
1P9O

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>936 bp
ATGGCGGAAATGGATCCGGTAGCCGAGTTCCCCCAGCCTCCCGGTGCTGCGCGCTGGGCT
GAGGTTATGGCTCGCTTCGCGGCCAGGCTGGGCGCGCAGGGCCGGCGGGTGGTGTTGGTT
ACGTCAGGCGGCACCAAGGTCCCACTGGAAGCGCGGCCGGTGCGCTTCCTGGACAACTTC
AGCAGCGGGCGGCGCGGTGCAACCTCGGCCGAGGCCTTCCTAGCCGCCGGCTACGGGGTC
CTGTTCTTGTATCGCGCTCGCTCTGCCTTCCCCTATGCCCACCGCTTCCCACCCCAGACT
TGGCTGTCCGCTCTGCGGCCTTCGGGCCCAGCCCTTTCGGGCTTGCTGAGCCTGGAGGCC
GAGGAGAATGCACTTCCGGGTTTTGCTGAGGCTCTGAGGAGCTACCAGGAGGCTGCGGCT
GCAGGCACCTTCCTGGCAGTAGAGTTCACCACTTTGGCGGACTATTTGCATCTGTTGCAG
GCTGCGGCCCAGGCACTCAATCCGCTAGGCCCTTCTGCGATGTTTTACCTGGCTGCGGCT
GTGTCAGATTTCTATGTTCCTGTCTCTGAAATGCCTGAACACAAGATCCAGTCATCTGGG
GGCCCACTGCAGATAACAATGAAGATGGTGCCAAAACTGCTTTCTCCTTTGGTTAAAGAT
TGGGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAGACTGACCCCGCCATTGTAATT
AATCGAGCTCGGAAGGCTTTGGAAATTTATCAGCATCAAGTGGTGGTGGCTAATATCCTT
GAGTCACGACAGTCCTTTGTGTTTATTGTAACCAAAGACTCGGAAACCAAGTTATTGCTA
TCAGAGGAAGAAATAGAAAAAGGCGTAGAGATAGAAGAGAAGATAGTGGATAATCTTCAG
TCTCGACACACAGCTTTTATAGGTGACAGAAACTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
AL445669

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_9_Locus:
Not Available

# Macromolecular_Interacting_Partner_9_SNPs:
Not Available

# Macromolecular_Interacting_Partner_9_General_References:
Not Available

# Macromolecular_Interacting_Partner_9_References:
Not Available

# Macromolecular_Interacting_Partner_10_ID:
8595

# Macromolecular_Interacting_Partner_10_Name:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Name:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>IL6
SAGESQRRRSPCQPFIGSGTHEVQLVPGTVHSLKQLKGLSPDTDATLSRMHGPGLTLSME
EVGSARGGRMVARDTESLVLGLWPS

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
82

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
8796

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
8.56

# Macromolecular_Interacting_Partner_10_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Signals:
Not Available

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
3065755

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
O60670_HUMAN (O60670)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
IL-6SAG

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
IL-6SAG

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:3368

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>250 bp
GGAATCCCAGAGAAGGAGAAGCCCCTGTCAACCTTTTATTGGGAGTGGAACACATGAGGT
TCAGCTCGTGCCGGGCACTGTACATTCACTGAAGCAGCTCAAGGGGCTCAGCCCCGACAC
TGACGCCACACTGAGCAGGATGCACGGCCCGGGGCTCACACTGTCCATGGAGGAGGTGGG
GTCAGCCCGAGGTGGGCGGATGGTGGCCCGAGACACCGAGAGCTTGGTTCTGGGACTGTG
GCCCAGCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
AF058296

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_10_Locus:
Not Available

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
Not Available

# Macromolecular_Interacting_Partner_10_References:
Not Available

# Macromolecular_Interacting_Partner_11_ID:
8651

# Macromolecular_Interacting_Partner_11_Name:
OTTHUMP00000030471

# Macromolecular_Interacting_Partner_11_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>
OTTHUMP00000030471MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPS
GSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGW
FLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYSPWLQMPCGP

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
16137

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
8.66

# Macromolecular_Interacting_Partner_11_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_11_General_Function:
Lipid transport and metabolism

# Macromolecular_Interacting_Partner_11_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_11_Signals:
Not Available

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
Q5TF43_HUMAN (Q5TF43)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
ACSS1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
ACSS1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:16091

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AL080312

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Not Available

# Macromolecular_Interacting_Partner_11_Locus:
Not Available

# Macromolecular_Interacting_Partner_11_SNPs:
Not Available

# Macromolecular_Interacting_Partner_11_General_References:
Not Available

# Macromolecular_Interacting_Partner_11_References:
Not Available

# Macromolecular_Interacting_Partner_12_ID:
8797

# Macromolecular_Interacting_Partner_12_Name:
Hypothetical protein PDE11A

# Macromolecular_Interacting_Partner_12_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Name:
PDE11A

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Hypothetical protein PDE11
AVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQT
LLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAEN

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
98

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
11231

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
5.19

# Macromolecular_Interacting_Partner_12_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Signals:
Not Available

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
62988743

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
Q53S07_HUMAN (Q53S07)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
PDE11A

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
PDE11A

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:8773

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>296 bp
GTTATGCAGATGTATCTTCCATTTTGTGGAATCGCCATATCTAACGCTCAGCTCTTTGCT
GCCTCAAGGAAAGAATATGAAAGAAGCAGAGCTTTGCTAGAGGTGGTTAATGACCTCTTT
GAAGAACAGACTGACCTGGAGAAAATTGTCAAGAAAATAATGCATCGGGCCCAAACTCTG
CTGAAATGTGAACGCTGTTCTGTTTTACTCCTAGAGGACATCGAATCACCAGTGGTGAAA
TTTACCAAATCCTTTGAATTGATGTCCCCAAAGTGCAGTGCTGATGCTGAGAACAG

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
AC073892

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_12_Locus:
2q31.2

# Macromolecular_Interacting_Partner_12_SNPs:
rs6705405; rs6734426; rs6734528; rs6734683; rs13034886; rs13010396; rs1438035; rs966433; rs1852503; rs1866212; rs1561316; rs2573088; rs941271; rs2886498; rs2695743; rs2365889; rs1465830; rs1469973; rs1438046; rs1880916; rs2573082; rs1982131; rs934798; rs2695760; rs1370662; rs1347731; rs1561319; rs1405650; rs2252726; rs2695109; rs1438054; rs1546813; rs1405646; rs1469972; rs1358326; rs1997208; rs2695099; rs1527399; rs1438063; rs1821628; rs2164860; rs1527293; rs1997206; rs1358327; rs1997207; rs2573083; rs1534290; rs1544001; rs1405651; rs1370661; rs2695740; rs1004541; rs934809; rs2118482; rs1370656; rs2037757; rs1344925; rs744397; rs1405647; rs753346; rs2060490; rs1347441; rs959157; rs1438038; rs2222711; rs1344922; rs744398; rs934803; rs1405648; rs1438037; rs2695098; rs1438051; rs1534289; rs1438048; rs934802; rs3770044; rs10497478; rs9288011; rs1344923; rs10170290; rs2695757; rs3108476; rs2695115; rs7583817; rs1866211; rs1527294; rs1369519; rs2020213; rs12693147; rs4893844; rs1106074; rs6433694; rs4893975; rs10497483; rs2695735; rs2573087; rs3108453; rs3770034; rs714528; rs4893980; rs998059; rs7560514; rs4413189; rs2695097; rs3770009; rs2573079; rs2886499; rs10198681; rs6746845; rs7563242; rs7606084; rs6433691; rs6760930; rs10198111; rs7570423; rs3770023; rs6737254; rs2043546; rs6718702; rs7573755; rs1370663; rs1020010; rs1370658; rs6433705; rs2695738; rs6433708; rs1438064; rs2695741; rs7588973; rs6433698; rs6749088; rs1561320; rs7605493; rs1527292; rs1991994; rs13421315; rs4893994; rs6721360; rs7570981; rs6433710; rs7588062; rs2886651; rs2695728; rs3770045; rs7600368; rs11684634; rs3770051; rs3754996; rs7586934; rs7578325; rs1465831; rs7605091; rs13026481; rs6758442; rs12693133; rs10186239; rs3770007; rs7573622; rs9679090; rs10930820; rs1405649; rs2217839; rs1527410; rs12693128; rs5025340; rs6726321; rs13389574; rs3910519; rs7591796; rs1435573; rs4893839; rs7569984; rs1527400; rs6718860; rs2695104; rs6745743; rs2695756; rs1898012; rs4893840; rs6758543; rs1344916; rs1830209; rs1438039; rs6738614; rs1997209; rs2043548; rs1527291; rs10198877; rs3951527; rs6726477; rs1527401; rs7591897; rs6433695; rs941274; rs6734520; rs1866209; rs7598623; rs959792; rs1369520; rs13026012; rs7595479; rs1004542; rs1527407; rs9288009; rs2365895; rs2695724; rs13429220; rs4893972; rs4522644; rs2695746; rs7557283; rs10207459; rs7559765; rs6708869; rs2886424; rs1438040; rs6720891; rs1946814; rs6741976; rs6733229; rs6743821; rs7608073; rs1527295; rs12693151; rs1866210; rs6737872; rs6433693; rs6750238; rs10930814; rs13428806; rs6751656; rs3770003; rs934804; rs12693127; rs6760512; rs6433709; rs2573085; rs10174604; rs2033762; rs6718657; rs2695103; rs3770018; rs10497493; rs6745288; rs1530035; rs1435574; rs1438049; rs4893985; rs10192481; rs6757651; rs10201180; rs11887429; rs1527296; rs4335982; rs2695112; rs2222712; rs880899; rs13009350; rs2695091; rs12990719; rs3821010; rs1527405; rs7605757; rs10497482; rs13402629; rs16865524; rs10189134; rs10497485; rs17635934; rs2015183; rs3731809; rs2033763; rs12693148; rs2695111; rs1358328; rs732363; rs12468127; rs10221806; rs6756994; rs12616259; rs1438045; rs1898585; rs12693146; rs6705118; rs2099476; rs13412319; rs13431084; rs12619453; rs12612171; rs13017429; rs6740251; rs6714519; rs4893995; rs13008780; rs1975323; rs2886500; rs2366352; rs7594290; rs12693123; rs7575322; rs6716496; rs10497494; rs13426862; rs10221783; rs17400325; rs11695452; rs13386639; rs1816520; rs6433685; rs6729482; rs3770015; rs7578901; rs11889185; rs13028757; rs1317945; rs9808399; rs4144275; rs2365896; rs1405718; rs17329956; rs1530034; rs11674668; rs17400505; rs7584946; rs6724986; rs13034781; rs3770047; rs12693145; rs6759712; rs10497479; rs4468852; rs12612509; rs13030747; rs3821007; rs4893987; rs10930805; rs1370655; rs12994494; rs17635957; rs2695094; rs880898; rs13390014; rs2573080; rs6433688; rs2695730; rs11883602; rs3770016; rs13389525; rs16866032; rs7568068; rs4337505; rs13017473; rs934801; rs12475250; rs13025391; rs4423634; rs16865995; rs17401468; rs17330172; rs6433711; rs1405645; rs12693130; rs10497495; rs4144276; rs10754990; rs16865872; rs2033760; rs16865498; rs11677821; rs12478277; rs11904461; rs13396537; rs10168641; rs11886258; rs13427906; rs11680652; rs10175364; rs16865645; rs10164920; rs3770050; rs13402636; rs2695729; rs13022684; rs1527402; rs7560080; rs2033761; rs6752264; rs12618542; rs10190805; rs12618537; rs17636610; rs13003683; rs1469971; rs17401650; rs4893976; rs4893988; rs10497480; rs10201150; rs13032794; rs934800; rs10191328; rs11903134; rs880897; rs6705472; rs12471621; rs12987101; rs6753870; rs10178985; rs2365625; rs16865492; rs17400931; rs1866215; rs10165396; rs6759109; rs1547580; rs13411922; rs2695732; rs13426284; rs6752409; rs13405585; rs6756240; rs4541282; rs3731808; rs3770008; rs2365619; rs1561318; rs17329742; rs16865906; rs16865604; rs17635803; rs4567975; rs3770005; rs6709256; rs6717171; rs10202985; rs16865535; rs10180052; rs10174066; rs3754993; rs12693149; rs10497496; rs10497486; rs13427960; rs2366353; rs2695737; rs2164859; rs3108451; rs10194370; rs10171486; rs7422544; rs6433697; rs11892557; rs1865588; rs1438062; rs6733980; rs6746482; rs13392051; rs2695742; rs2091442; rs6739583; rs6750869; rs13419437; rs1527403; rs1866208; rs10197020; rs6726502; rs6433690; rs7422960; rs1547581; rs4893981; rs1898013; rs13429445; rs12612481; rs2164857; rs11686720; rs6712082; rs4243392; rs13410185; rs16866042; rs3770011; rs16865503; rs1837163; rs17329998; rs10211057; rs12151755; rs12613207; rs11679730; rs7604345; rs7591800; rs16865494; rs1358299; rs4470372; rs10497488; rs6736927; rs7567851; rs941276; rs9677333; rs7421260; rs10930809; rs6707034; rs10202989; rs3770048; rs934806; rs12693129; rs7597640; rs3915272; rs10208501; rs12693143; rs11678875; rs17400512; rs7588301; rs17687170; rs11687117; rs12616321; rs13025904; rs1821629; rs13008170; rs6715232; rs12995449; rs13425873; rs2695725; rs3770035; rs3770028; rs3821009; rs11680632; rs3770012; rs10192225; rs1837164; rs13015148; rs12618150; rs10170914; rs11896183; rs4893989; rs1527288; rs3770019; rs10172800; rs17401293; rs6704720; rs13017234; rs12693150; rs11904417; rs7562835; rs13386418; rs1946813; rs7559596; rs11690740; rs10175970; rs16865825; rs4341975; rs11687543; rs13009207; rs2886653; rs12463866; rs13017026; rs6755503; rs4893979; rs17401860; rs12693142; rs16865901; rs17402102; rs3821008; rs16865703; rs998060; rs7577552; rs6718206; rs10930815; rs10497487; rs13398310; rs4446096; rs12469388; rs2164858; rs11892483; rs7566399; rs6713981; rs1438060; rs4110134; rs17400121; rs6748696; rs3770053; rs13022805; rs7558310; rs12693131; rs3754991; rs7573345; rs7595951; rs10183144; rs10497492; rs2365620; rs10170607; rs7561059; rs10171247; rs1405716; rs1544003; rs749208; rs6718993; rs13398604; rs10197329; rs13003047; rs7593753; rs999218; rs1106075; rs10210259; rs3770010; rs1370657; rs6708025; rs1025598; rs12618596; rs1435575; rs12473461; rs934808; rs6709966; rs11674299; rs934799; rs959775; rs1370664; rs13000926; rs11893349; rs11883778; rs1544002; rs4893984; rs13411542; rs10497490; rs16865819; rs17330290; rs2117740; rs6756606; rs7579625; rs1554776; rs10497484; rs16865756; rs10191015; rs1405714; rs17401902; rs16866000; rs749207; rs7605744; rs4893847; rs11891283; rs12619506; rs2695092; rs13014883; rs2360221; rs17687590; rs12472886; rs13428032; rs10497491; rs2164330; rs13008833; rs13413095; rs1438036; rs1561317; rs17635875; rs1852497; rs13384920; rs13411527; rs6754385; rs12618606; rs6738831; rs9288008; rs2695726; rs13422276; rs13396065; rs10930817; rs13012431; rs7605609; rs13422706; rs1344917; rs934807; rs7596644; rs6724987; rs1852500; rs12693144; rs13411970; rs7570898; rs6433704; rs6739044; rs2009303; rs1898587; rs6433687; rs6727390; rs7592278; rs13395965; rs12994405; rs13002118; rs11899173; rs16865821; rs7609487; rs10186273; rs6758923; rs12620627; rs2365899; rs13034432; rs13419927; rs6750991; rs7584838; rs35625771; rs13427929; rs13006992; rs13427912; rs16865697; rs10165299; rs7598835; rs13427600; rs9808095; rs13422021; rs13429906; rs10930819; rs7420642; rs10169917; rs10168605; rs16865643; rs12474141; rs4893986; rs16865593; rs6734297; rs7595421; rs7424429; rs11884289; rs6721029; rs13394480; rs16865835; rs10930806; rs13007187; rs10178125; rs6724505; rs7598748; rs6758297; rs11695211; rs16865887; rs2365898; rs16865921; rs12478848; rs17330075; rs13008857; rs9283485; rs16865912; rs12477170; rs16865743; rs2695723; rs10165196; rs12151806; rs13014945; rs13391502; rs6716206; rs16865998; rs16865753; rs7558301; rs16865852; rs10192990; rs10181377; rs12611503; rs1438053; rs16865752; rs7577174; rs16865698; rs16865791; rs17400526; rs1975324; rs7574565; rs1534305; rs10181024; rs16866036; rs17400834; rs6747512; rs6433686; rs7577598; rs16865493; rs13010041; rs13410486; rs10183838; rs13021998; rs13021204; rs1918347; rs12105799; rs2695721; rs17330012; rs13392577; rs13007766; rs7569124; rs12988331; rs10200643; rs1595443; rs6737549; rs10202536; rs4508637; rs9288013; rs12465539; rs16865848; rs2695744; rs3770013; rs13004037; rs16866003; rs2365621; rs16865844; rs1898588; rs2695101; rs1975321; rs13393722; rs1986843; rs9679360; rs9646795; rs3754994; rs934569; rs4511758; rs6760949; rs4324348; rs10186678; rs10176232; rs7556748; rs6746962; rs12613904; rs12989020; rs2365618; rs16866031; rs2695720; rs13413635; rs10165192; rs16865933; rs13019660; rs3770043; rs7588304; rs2056715; rs7568082; rs12616288; rs9679242; rs3770014; rs16865642; rs4277559; rs16865772; rs7557136; rs13398395; rs12622125; rs9677101; rs13006098; rs10208589; rs4456736; rs13004202; rs6745398; rs6755382; rs7593744; rs6758473; rs11684363; rs2178018; rs1898589; rs10193299; rs10179500; rs13421432; rs13408518; rs13023939; rs13386827; rs13395151; rs10195518; rs10179821; rs1347730; rs16865748; rs13386657; rs1370660; rs6433700; rs6738098; rs12469884; rs16865706; rs7609350; rs7607094; rs2695747; rs16865850; rs12987515; rs6729216; rs10168715; rs17401951; rs12994913; rs10182150; rs2695752; rs13007759; rs1438055; rs11885059; rs13423503; rs6708449; rs7596360; rs10497477; rs16865527; rs10497489; rs4585066; rs1370659; rs1344924; rs10432481; rs11684953; rs10497481; rs12615564; rs16865651; rs10184562; rs11901841; rs10432482; rs3770036; rs1369518; rs2366354; rs13030321; rs11888049; rs16865771; rs1898590; rs941272; rs17329531; rs16865684; rs16865846; rs10165826; rs13014074; rs6747480; rs2695731; rs6761951; rs10168170; rs1946812; rs1866214; rs10930810; rs4893977; rs11694948; rs12612475; rs7423941; rs12990471; rs2695734; rs4893978; rs1438056; rs11682717; rs7570577; rs10176298; rs4893971; rs1547582; rs6731237; rs9653239; rs2695748; rs1527408; rs13421772; rs17636214; rs1344920; rs16865625; rs12467363; rs13384016; rs7557138; rs10211367; rs17329062; rs10469714; rs2695108; rs13018609; rs13408911; rs1949965; rs9679120; rs12475108; rs1527409; rs16865726; rs16865839; rs934567; rs13424417; rs7607529; rs1527406; rs10190199; rs3861373; rs1527290; rs10181136; rs10202419; rs10432483; rs11690583; rs1898586; rs2365622; rs13021356; rs10194612; rs12466205; rs2695745; rs2886422; rs998061; rs16865694; rs10930812; rs11683425; rs11896144; rs13413731; rs17401916; rs12615826; rs1918346; rs13399957; rs10195497; rs1405644; rs3770022; rs7578601; rs10171079; rs13406220; rs16823484; rs3214674; rs16865907; rs16865999; rs6433681; rs10803914; rs13411661; rs16865668; rs10166083; rs10203217; rs16865764; rs17687217; rs2950408; rs10164794; rs2695105; rs10187879; rs6735911; rs13385960; rs6714147; rs16865711; rs6714540; rs1405717; rs13403540; rs13395159; rs4893838; rs6712039; rs6735387; rs1438041; rs11894110; rs16866043; rs17401986; rs6709222; rs7562940; rs6743194; rs10173243; rs13012088; rs4893983; rs1561315; rs3770027; rs10202188; rs934568; rs10190154; rs10206282; rs10182386; rs16865670; rs2043547; rs2695096; rs6761540; rs1438058; rs13421135; rs10180071; rs10172247; rs17329811; rs11885795; rs13391629; rs16865533; rs6706739; rs9973525; rs2886423; rs16865951; rs10930811; rs1949966; rs764780; rs934805; rs7575717; rs16865647; rs13412181; rs13421415; rs7591504; rs10165089; rs9989817; rs11898798; rs13023495; rs6726253; rs1852498; rs6731843; rs7565183; rs3821011; rs16865869; rs16865868; rs10930822; rs1438059; rs10189110; rs12151805; rs16865940; rs16865591; rs1527297; rs7581861; rs11901771; rs1530036; rs10190066; rs7560737; rs2695750; rs714529; rs6433683; rs16865838; rs7592731; rs13396204; rs7563140; rs6704966; rs10930818; rs3770054; rs1344919; rs2695095; rs13397448; rs16865903; rs16865514; rs6731684; rs17401671; rs2365894; rs6726809; rs16865829; rs13423418; rs4143805; rs10178433; rs2695727; rs16865678; rs16865641; rs16865676; rs10167783; rs10168657; rs13425796; rs16865709; rs10192255; rs6711886; rs13396207; rs16865767; rs7588187; rs13395521; rs6713949; rs13409414; rs7592459; rs1438047; rs1527404; rs6709092; rs10176133; rs10930804; rs9989802; rs3770032; rs9677392; rs7565182; rs16865776; rs2365897; rs16865509; rs10930821; rs13400109; rs13400411; rs11899873; rs16865858; rs16865617; rs13414329; rs1358300; rs9288012; rs7585543; rs4377360; rs11902106; rs2020215; rs6717814; rs7573820; rs6433684; rs16865576; rs10166758; rs10211341; rs13394477; rs35397469; rs6756948; rs4893973; rs17687668; rs12469439; rs10186953; rs13387463; rs16865769; rs16865818; rs16865833; rs2060491; rs10177961; rs13028692; rs11674779; rs4893974; rs9677970; rs13386870; rs10169010; rs16865508; rs2365623; rs10930813; rs11890088; rs16865862; rs13002444; rs35987785; rs16865885; rs3952630; rs1344921; rs16865700; rs7581711; rs13392161; rs11682753; rs16866034; rs3821006; rs726985; rs16865689; rs10209050; rs3770046; rs7565179; rs3770029; rs16865701; rs6718100; rs9677090; rs934570; rs4474917; rs16865501; rs6723031; rs6730406; rs920092; rs6723063; rs920093; rs6722891; rs920094; rs1347440; rs920095; rs12468187; rs34839657; rs35253164; rs1946702; rs35210671; rs1982132; rs34365455; rs13005502; rs3056853; rs2695736; rs35071676; rs35669568; rs7421536; rs10167777; rs35607901; rs10201731; rs34374310; rs12994303; rs35897066; rs941366; rs35952531; rs34795277; rs35691085; rs7586771; rs10183014; rs28679800; rs34956941; rs34744300; rs34148524; rs13423344; rs34041168; rs6708473; rs35233809; rs34463789; rs10183536; rs34568807; rs35365213; rs34298599; rs3770031; rs35641196; rs13427473; rs41429950; rs35218489; rs35716038; rs35168006; rs35207489; rs35698274; rs34234621; rs34528505; rs3067363; rs2695100; rs5836630; rs10669353; rs41397549; rs35200915; rs12615720; rs13428260; rs1595442; rs35815103; rs11457930; rs35972715; rs35782989; rs35450676; rs33997655; rs35184228; rs11273279; rs34378430; rs35625068; rs13413922; rs35931940; rs12465589; rs34717744; rs34130310; rs12991811; rs13407054; rs956410; rs7567962; rs35810469; rs12998308; rs12992347; rs2886652; rs5836633; rs5836625; rs3813254; rs10174152; rs13409408; rs34459847; rs34543540; rs11421886; rs1438052; rs10654194; rs13011140; rs11457660; rs6433692; rs16865870; rs28380215; rs7600557; rs16865855; rs34233581; rs34509785; rs35068650; rs35319085; rs35244974; rs6741812; rs36180727; rs2366351; rs35894325; rs28700947; rs35793465; rs12990178; rs11352844; rs11304036; rs6147043; rs2695110; rs34434094; rs34839662; rs13409520; rs16865786; rs3056901; rs13013052; rs11895601; rs34245692; rs35699369; rs34622176; rs34326338; rs16866002; rs35267683; rs3056858; rs5836628; rs35020639; rs34909518; rs34605619; rs34338097; rs35391652; rs10195936; rs11290620; rs1852499; rs34327277; rs6758508; rs12989513; rs2695114; rs5836640; rs28496693; rs36051210; rs4302244; rs34025288; rs4110130; rs9677138; rs10167356; rs10622468; rs35391362; rs34677149; rs13408009; rs2695758; rs35268083; rs10558379; rs34921790; rs36186712; rs13399953; rs35319486; rs34242723; rs6710818; rs34632698; rs10167418; rs13383696; rs3905344; rs5836622; rs35615752; rs1123138; rs35635398; rs10654163; rs10527143; rs34093593; rs35892092; rs12989062; rs35775900; rs3835950; rs10187874; rs34928961; rs36003437; rs5836636; rs34403322; rs6756270; rs35443310; rs2695749; rs34356580; rs10686756; rs13018347; rs3835952; rs28498363; rs34698321; rs33980746; rs12999814; rs7575777; rs35723966; rs11400619; rs35537949; rs12151372; rs35063921; rs3073405; rs35277317; rs11460197; rs34661271; rs33952943; rs11297475; rs9679102; rs10209248; rs34358653; rs6739045; rs10193573; rs34678364; rs34644164; rs16823485; rs35134722; rs11365222; rs2573081; rs35105885; rs10176536; rs6433689; rs2695751; rs1020011; rs34334554; rs13409454; rs13426623; rs10546304; rs7569826; rs13024864; rs4417752; rs11357476; rs11423127; rs6753377; rs1438043; rs10697352; rs13426123; rs11374940; rs36043707; rs35875834; rs34479958; rs12328658; rs34144749; rs34283040; rs35610210; rs13002398; rs2695093; rs35805580; rs3841879; rs5836635; rs35486028; rs35969908; rs36121526; rs4893990; rs7584732; rs36197320; rs34088312; rs2695318; rs36130267; rs10190750; rs1866213; rs11304532; rs12466953; rs3056896; rs941273; rs13409258; rs34430258; rs36033403; rs11332498; rs34293348; rs34718493; rs34648335; rs35600620; rs35749062; rs13420280; rs34108864; rs35262842; rs13432633; rs35217344; rs7607438; rs13021169; rs13001148; rs10176527; rs34087687; rs28590730; rs35758079; rs13416761; rs35427161; rs13001447; rs10557532; rs4019842; rs12986929; rs3835949; rs16865485; rs36058776; rs11399942; rs36210065; rs6729893; rs5836632; rs35228328; rs6731331; rs13013706; rs941365; rs34385021; rs35391554; rs35885074; rs35323285; rs10168683; rs34952652; rs34444737; rs34330215; rs36118068; rs4464320; rs35219250; rs13382373; rs12992086; rs34973644; rs13018404; rs16865713; rs4893982; rs10211625; rs34035940; rs2950572; rs6758139; rs35812247; rs7421535; rs35011517; rs3067362; rs12995165; rs13430954; rs5836641; rs12999027; rs35046636; rs12612301; rs34596457; rs35254631; rs35906687; rs4297923; rs1975322; rs34035499; rs1527289; rs35862134; rs3770042; rs2091441; rs34406776; rs9677777; rs13007385; rs10556235; rs34486056; rs13029844; rs35102487; rs13023837; rs10692818; rs34464620; rs34330915; rs35517342; rs35848472; rs34582585; rs16865918; rs35288915; rs35902413; rs13389387; rs6433707; rs34369002; rs34417507; rs34790520; rs34510795; rs34612479; rs34602607; rs2365624; rs10209852; rs2695761; rs11457371; rs3056940; rs35549571; rs28791491; rs11892897; rs36013928; rs11887774; rs10176535; rs35290022; rs6725044; rs33984696; rs35420167; rs10172384; rs34505237; rs12997716; rs12994392; rs34366957; rs34210867; rs34772724; rs1852496; rs12618253; rs36180284; rs35305315; rs12992938; rs36003055; rs34392533; rs34682002; rs10685021; rs34595897; rs5836620; rs3830637; rs35655847; rs1438044; rs2573084; rs35231531; rs34945224; rs35156922; rs12472798; rs34934707; rs10669885; rs13009183; rs35939912; rs5836626; rs35688482; rs7571646; rs11310982; rs34365395; rs33967413; rs7421195; rs34327803; rs10572990; rs35642038; rs10175142; rs6433696; rs4893846; rs13007409; rs34717034; rs35462778; rs5836619; rs10432484; rs11333080; rs33971104; rs12993389; rs4487117; rs5836631; rs35217913; rs3037874; rs35797524; rs13031478; rs34142188; rs34917842; rs11685582; rs3037901; rs35338943; rs5836623; rs34767203; rs6712779; rs34682886; rs34206020; rs12472460; rs35337472; rs3073403; rs883171; rs13023528; rs10190560; rs3066395; rs35421971; rs13019139; rs35798690; rs13408844; rs11901207; rs34902120; rs34884047; rs34567061; rs1438042; rs10603345; rs13010993; rs34794477; rs35316377; rs35726367; rs13013319; rs35837681; rs35253854; rs5836638; rs5836629; rs13391481; rs6731280; rs34147365; rs3770021; rs34261053; rs28787871; rs35996255; rs13029944; rs13016598; rs2695722; rs35267698; rs28867487; rs13033904; rs36022334; rs11378638; rs34355087; rs34532538; rs12994400; rs34743754; rs12992244; rs13401710; rs10608828; rs34449576; rs13431317; rs13406131; rs35757742; rs35810822; rs36042877; rs1609094; rs2695739; rs2365891; rs34096798; rs959791; rs1467360; rs34758781; rs3770041; rs12998843; rs34556327; rs36035504; rs35120376; rs34413904; rs11898579; rs6708580; rs34448095; rs10178916; rs36005794; rs10187897; rs34650718; rs35691613; rs35343829; rs35952657; rs1438057; rs10178858; rs2717524; rs2118483; rs7602131; rs2695090; rs3056854; rs34059969; rs36021106; rs10185318; rs34216494; rs10211637; rs11680530; rs35104703; rs10690181; rs13017462; rs5025339; rs34171827; rs3770037; rs11333128; rs34330646; rs2695759; rs10185973; rs34484134; rs5015687; rs3031405; rs35765328; rs10684663; rs13031632; rs34503988; rs34692952; rs36088611; rs36161140; rs7605249; rs2695733; rs3770030; rs11333208; rs11457658; rs2196339; rs10700821; rs11409979; rs33971087; rs35212627; rs12476700; rs4464321; rs34302432; rs10194586; rs35611922; rs28408453; rs13007673; rs13415041; rs33957872; rs5836637; rs35064446; rs34364822; rs7571908; rs35531468; rs10613859; rs34995971; rs34148492; rs35924394; rs35678669; rs13405755; rs4487116; rs10614762; rs35194777; rs13028628; rs12473852; rs35134190; rs12990878; rs35887587; rs3948256; rs34381368; rs10182833; rs35525333; rs2573086; rs3067378; rs34721738; rs10534597; rs2365890; rs13405457; rs10183345; rs13394193; rs941275; rs4536679; rs35362919; rs10176643; rs13026166; rs13006712; rs13385419; rs12233175; rs13001444; rs2717525; rs33997176; rs11363547; rs28529577; rs12992252; rs10427227; rs35631376; rs11367453; rs35097265; rs12612164; rs34842463; rs6414096; rs10187884; rs35795321; rs35302466; rs13416636; rs13024861; rs35990574; rs2695754; rs7605985; rs10185145; rs10182353; rs3056942; rs13018132; rs34938001; rs35041048; rs10539109; rs13024254; rs11329681; rs34952215; rs2695106; rs13418653; rs13421345; rs5836627; rs34513757; rs35586165; rs3056937; rs13020684; rs34383497; rs6738358; rs7571919; rs5015686; rs10556225; rs12988281; rs13388218; rs34385779; rs34054341; rs35335000; rs10930808; rs11291265; rs28707296; rs2366350; rs34624647; rs12992249; rs2886425; rs34878348; rs35248478; rs13001522; rs34660521; rs34081471; rs4341976; rs35975029; rs35773107; rs13418469; rs34682348; rs35764219; rs10182017; rs10186697; rs6731030; rs35927962; rs34281475; rs34018298; rs35782761; rs12987271; rs7558482; rs1918345; rs34823486; rs4110136; rs11284596; rs34568974; rs34915755; rs13405581; rs34164632; rs35225617; rs3770017; rs3037903; rs13427846; rs34702209; rs9646739; rs4538242; rs35978357; rs35481440; rs1344918; rs34948302; rs10564225; rs35303018; rs10534752; rs13022267; rs3770020; rs35929026; rs41394144; rs13002209; rs13027484; rs2118481; rs10563932; rs35404128; rs34110195; rs6758644; rs34323062; rs2196340; rs35748044; rs41440047; rs34246439; rs13427452; rs34792403; rs12994590; rs35830357; rs13396582; rs10579905; rs13012298; rs13385424; rs35517887; rs11450947; rs35522885; rs1358301; rs6713660; rs35696051; rs10629866; rs35973852; rs35591668; rs28771225; rs12472515; rs34764794; rs34507449; rs13383409; rs34473216; rs34249286; rs10803913; rs4338993; rs35420534; rs1880915; rs2695113; rs35520979; rs34473720; rs6723691; rs35578521; rs35733927; rs13023390; rs13023494; rs4893836; rs35983142; rs5836639; rs2695107; rs35749582; rs34149684; rs13019623; rs1438050; rs36046079; rs28621588; rs13385949; rs2083156; rs10541503; rs6716288; rs34335666; rs3066392; rs35403482; rs34431240; rs35439189; rs35316735; rs3056898; rs5836624; rs28889598; rs7421650; rs10187888; rs11343355; rs28536016; rs6147041; rs7420029; rs2037758; rs10930807; rs7565114; rs34185358; rs10192928; rs35873373; rs3031403; rs13020834; rs5836618; rs10211632; rs16865909; rs35728831; rs13025164; rs36032173; rs6147042; rs36149489; rs35130337; rs34164917; rs34684690; rs35836349; rs34215270; rs12992250; rs34628381; rs7573440; rs13017254; rs41357848; rs10178473; rs2365892; rs10693827; rs9646738; rs35538692; rs35385829; rs33947390; rs36106717; rs34752624; rs7589980; rs34839058; rs35709030; rs34699522; rs6747137; rs13393975; rs34571198; rs36062129; rs2196694; rs34747248; rs6711034; rs12987107; rs35510151; rs34363929; rs10558072; rs5836634; rs34047994; rs1609095; rs13013724; rs34293884; rs13419130; rs2695755; rs934810; rs34044811; rs2196341; rs36094310; rs3770049; rs3056903; rs12993458; rs7594362; rs13002711; rs13002713; rs13027895; rs11694013; rs34941794; rs10174337; rs10209616; rs1047884; rs11676719; rs12620285; rs12990917; rs13023049; rs13032997; rs13033229; rs13397357; rs13419755; rs13421475; rs1369517; rs1405643; rs1435572; rs1527286; rs1527287; rs1534304; rs16865452; rs16865453; rs16865475; rs16865476; rs16865993; rs16866025; rs16866053; rs16866058; rs17330381; rs1836672; rs1982130; rs2117739; rs2293471; rs2293472; rs2293473; rs3829751; rs3829752; rs4436997; rs4893970; rs6710329; rs6720272; rs6726222; rs6740828; rs6752913; rs6754705; rs6756918; rs7574975

# Macromolecular_Interacting_Partner_12_General_References:
Not Available

# Macromolecular_Interacting_Partner_12_References:
Not Available

End of HMDB00045

Beginning of HMDB00048
# Accession_No:
HMDB00048

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-05-23 11:06:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Melibiose

# Description:
A disaccharide consisting of one galactose and one glucose moiety in an alpha (1-6) glycosidic linkage.  This sugar is produced and metabolized only by enteric and lactic acid bacteria and other microbes.  It is not an endogenous metabolite.  Antibodies to melibiose will appear in individuals affected by Chagas' disease (Trypanosoma cruzi infection).  Melibiose is not metabolized by humans.

# Synonyms:
6-(D-galactosido)-D-glucose; 6-(a-D-galactosido)-D-glucose; 6-O-Hexopyranosylhexose; 6-O-a-D-galactopyranosyl-D-Glucose; 6-O-alpha-D-galactopyranosyl-D-Glucose; D-(+)-Melibiose; D-Melibiose; Melibiose; Mellibiose; alpha-D-Melibiose; alpha-Melibiose; 6-(D-galactosido)-delta-glucose; 6-(a-delta-galactosido)-delta-glucose; 6-O-alpha-delta-galactopyranosyl-delta-Glucose; delta-(+)-Melibiose; delta-Melibiose; alpha-delta-Melibiose

# Chemical_IUPAC_Name:
2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal

# Chemical_Formula:
C12H22O11

# Chemical_Structure:
tbl_chemical:::HMDB00048_ZOOM.png:::11928315440527966

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00048_THUMB.png:::119283154188120198

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Sugars; Disaccharides

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiacetal; acetal; primary alcohol; secondary alcohol; 1,2-diol; heterocyclic compound

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
342.11621

# Molecular_Weight_Avg:
342.29651

# Smiles_String_isomeric:
OC[C@H]1O[C@H](OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O

# Smiles_String_canonical:
OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1O

# KEGG_Compound_ID:
C05402

# BioCyc_ID:
MELIBIOSE

# PubChem_CID:
440658

# PubChem_SID:
7769; 10298632

# OMIM_ID:
Not Available

# Metagene_ID:
Not Available

# BiGG_ID:
Not Available

# Wikipedia_ID:
Not Available

# METLIN_ID:
3478

# Ref_ID:
1706399; 7795409; 7576587; 7524207; 10585631; 8919354; 528053; 7842233; 10799474; 809216; 8521444

# ChEBI_ID:
28053

# CAS_Registry_Number:
585-99-9

# InChI:
InChI=1/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11u,12+/m1/s1

# Synthesis_Reference:
Rapid oligosaccharide synthesis on a fluorous support.     Goto, Kohtaro; Miura, Tsuyoshi; Hosaka, Daisuke; Matsumoto, Hiroharu; Mizuno, Mamoru; Ishida, Hide-ki; Inazu, Toshiyuki.    Labolatry of Glycoorganic Chemistry,  The Noguchi Institute,  Itabashi-k

# Melting_Point:
84 oC

# Melting_Point_predicted:
141.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
1000.0 mg/mL [MERCK INDEX (1996)]

# H2O_Solubility_Predicted:
511.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-3.00 [Predicted by ALOGPS]; -4.1 [Predicted by PubChem via XLOGP]; -5.30 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
Not Available

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::C05402.mol:::1132723803390481914

# SDF_File_[Text]:
tbl_chemical:::HMDB00048.sdf:::119283153632273721

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00048.pdb:::11928315401971620

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_presat.png:::114624884159485807

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_presat.zip:::11462488416009837

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041026_P00_02_HW_1DP_Assigned.png:::115635569859985468

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15.jpg:::114168459743453391

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15.zip:::114168459740464338

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041026_P00_02_HW_1DC_15_Assigned.jpg:::114488011236360058

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114.jpg:::114495744616348812

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114.zip:::114495744618634631

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041026_P00_02_HW_2DHSQC_114_Assigned.jpg:::115929340085761096

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Melibiose.gif:::11532492327457031

# pred_hnmr_peaklist:
Not Available

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Melibiose_C.gif:::115324923277017534

# pred_cnmr_peaklist:
Not Available

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00048.png:::1165435230637597580; Medium Energy:tbl_ms:::HMDB00048.png:::116543466515143814; High Energy:tbl_ms:::HMDB00048.png:::1165434857212326714

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Extracellular; Cytoplasm (Predicted from LogP)

# Tissue_Location:
Spleen; Tissues Containing Microbial Flora

# deuterated:
No

# Biofluid_Location:
Urine

# Concentration_[Normal]:
Urine	< 0.1	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	10585631


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Chagas' Disease; Paediatric short-bowel syndrome

# Pathway_Names:
Galactose metabolism;Starch and sucrose metabolism;Glycerolipid metabolism;Glycosphingolipid metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00052;map00500;map00561;map00600

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5997

# Metabolic_Enzyme_1_Name:
Alpha-galactosidase A precursor

# Metabolic_Enzyme_1_Synonyms:
Melibiase; Alpha-D- galactoside galactohydrolase; Alpha-D-galactosidase A; Agalsidase alfa

# Metabolic_Enzyme_1_Gene_Name:
GLA

# Metabolic_Enzyme_1_Protein_Sequence:
>Alphagalactosidase A precursor
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL

# Metabolic_Enzyme_1_Number_of_Residues:
429

# Metabolic_Enzyme_1_Molecular_Weight:
48767

# Metabolic_Enzyme_1_Theoretical_pI:
5.27

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on glycosyl bonds
Function:  hydrolase activity, hydrolyzing O-glycosyl compounds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Hydrolysis of terminal, non-reducing alpha-D- galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase

# Metabolic_Enzyme_1_Pathway:
map00052  Galactose metabolism;
 map00561  Glycerolipid metabolism;
 map00600  Glycosphingolipid metabolism;
 map00603  Globoside metabolism

# Metabolic_Enzyme_1_Reaction:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF02065:Melibiase

# Metabolic_Enzyme_1_Signals:
1-31

# Metabolic_Enzyme_1_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.2.1.22

# Metabolic_Enzyme_1_GenBank_ID_Protein:
757912

# Metabolic_Enzyme_1_SwissProt_ID:
AGAL_HUMAN (P06280)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GLA

# Metabolic_Enzyme_1_Geneatlas_id:
GLA

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4296

# Metabolic_Enzyme_1_PDB_ID:
1R47

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Lysosome

# Metabolic_Enzyme_1_Gene_Sequence:
>1290 bp
ATGCAGCTGAGGAACCCAGAACTACATCTGGGCTGCGCGCTTGCGCTTCGCTTCCTGGCC
CTCGTTTCCTGGGACATCCCTGGGGCTAGAGCACTGGACAATGGATTGGCAAGGACGCCT
ACCATGGGCTGGCTGCACTGGGAGCGCTTCATGTGCAACCTTGACTGCCAGGAAGAGCCA
GATTCCTGCATCAGTGAGAAGCTCTTCATGGAGATGGCAGAGCTCATGGTCTCAGAAGGC
TGGAAGGATGCAGGTTATGAGTACCTCTGCATTGATGACTGTTGGATGGCTCCCCAAAGA
GATTCAGAAGGCAGACTTCAGGCAGACCCTCAGCGCTTTCCTCATGGGATTCGCCAGCTA
GCTAATTATGTTCACAGCAAAGGACTGAAGCTAGGGATTTATGCAGATGTTGGAAATAAA
ACCTGCGCAGGCTTCCCTGGGAGTTTTGGATACTACGACATTGATGCCCAGACCTTTGCT
GACTGGGGAGTAGATCTGCTAAAATTTGATGGTTGTTACTGTGACAGTTTGGAAAATTTG
GCAGATGGTTATAAGCACATGTCCTTGGCCCTGAATAGGACTGGCAGAAGCATTGTGTAC
TCCTGTGAGTGGCCTCTTTATATGTGGCCCTTTCAAAAGCCCAATTATACAGAAATCCGA
CAGTACTGCAATCACTGGCGAAATTTTGCTGACATTGATGATTCCTGGAAAAGTATAAAG
AGTATCTTGGACTGGACATCTTTTAACCAGGAGAGAATTGTTGATGTTGCTGGACCAGGG
GGTTGGAATGACCCAGATATGTTAGTGATTGGCAACTTTGGCCTCAGCTGGAATCAGCAA
GTAACTCAGATGGCCCTCTGGGCTATCATGGCTGCTCCTTTATTCATGTCTAATGACCTC
CGACACATCAGCCCTCAAGCCAAAGCTCTCCTTCAGGATAAGGACGTAATTGCCATCAAT
CAGGACCCCTTGGGCAAGCAAGGGTACCAGCTTAGACAGGGAGACAACTTTGAAGTGTGG
GAACGACCTCTCTCAGGCTTAGCCTGGGCTGTAGCTATGATAAACCGGCAGGAGATTGGT
GGACCTCGCTCTTATACCATCGCAGTTGCTTCCCTGGGTAAAGGAGTGGCCTGTAATCCT
GCCTGCTTCATCACACAGCTCCTCCCTGTGAAAAGGAAGCTAGGGTTCTATGAATGGACT
TCAAGGTTAAGAAGTCACATAAATCCCACAGGCACTGTTTTGCTTCAGCTAGAAAATACA
ATGCAGATGTCATTAAAAGACTTACTTTAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X05790

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_1_Locus:
Xq22

# Metabolic_Enzyme_1_SNPs:
rs2071228; rs2071397; rs5991933; rs3027588; rs2071396; rs11795552; rs1023431; rs2515901; rs5991931; rs12392549; rs28935493; rs28935495; rs28935488; rs28935486; rs28935492; rs28935489; rs28935485; rs28935487; rs28935490; rs28935494; rs28935491; rs28452934; rs2473815; rs5903184; rs34068797; rs3027591; rs12841946; rs41311559; rs1023432; rs36101431; rs34320747; rs34454314; rs11448515; rs3027589; rs36058885; rs35370748; rs35549513; rs35394408; rs34194580; rs1023433; rs41307413; rs35691745; rs3027590; rs3027592; rs34242315; rs12394005; rs34891827; rs35186437; rs35512527; rs35765403; rs34004522; rs5991932; rs7051126; rs35785460; rs10673283; rs34192850; rs35019768; rs1050058; rs2071226; rs2071227; rs2143597; rs2361007; rs3027575; rs3027576; rs3027577; rs3027578; rs3027579; rs3027580; rs3027581; rs3027582; rs3027583; rs3027584; rs3027586; rs3027593; rs3027594; rs3027595; rs3027596; rs3027597; rs3027598; rs3027599; rs3027600; rs5951308; rs6621053; rs6621054

# Metabolic_Enzyme_1_General_References:
3036505; 2542896; 7626884; 3014515; 2892762; 2836863; 7503918; 7911050; 2152885; 1846223; 2171331; 2539398; 1315715; 7504405; 8395937; 8069316; 7531540; 7575533; 7759078; 7599642; 7596372; 8875188; 8834244; 8931708; 8807334; 8863162; 9105656; 9100224; 9452068; 9452090; 9452111; 10208848; 10090526; 10666480; 11076046; 10916280; 11295840; 11668641

# Metabolic_Enzyme_1_References:
11526023; 1337134; 15582614; 1651679

# Macromolecular_Interacting_Partner_1_ID:
7948

# Macromolecular_Interacting_Partner_1_Name:
Galectin-4

# Macromolecular_Interacting_Partner_1_Synonyms:
Lactose-binding lectin 4; L-36 lactose-binding protein; L36LBP; Antigen NY-CO-27

# Macromolecular_Interacting_Partner_1_Gene_Name:
LGALS4

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Galectin4
MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDV
AFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNP
FYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLP
TMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPR
MGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHR
LSAFQRVDTLEIQGDVTLSYVQI

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
323

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
35942

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
9.48

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  binding
Function:  carbohydrate binding
Function:  sugar binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00337:Gal-bind_lectin

# Macromolecular_Interacting_Partner_1_Signals:
None

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
2385454

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
LEG4_HUMAN (P56470)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
LGALS4

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
LGALS4

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6565

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>972 bp
ATGGCCTATGTCCCCGCACCGGGCTACCAGCCCACCTACAACCCGACGCTGCCTTACTAC
CAGCCCATCCCGGGCGGGCTCAACGTGGGAATGTCTGTTTACATCCAAGGAGTGGCCAGC
GAGCACATGAAGCGGTTCTTCGTGAACTTTGTGGTTGGGCAGGATCCGGGCTCAGACGTC
GCCTTCCACTTCAATCCGCGGTTTGACGGCTGGGACAAGGTGGTCTTCAACACGTTGCAG
GGCGGGAAGTGGGGCAGCGAGGAGAGGAAGAGGAGCATGCCCTTCAAAAAGGGTGCCGCC
TTTGAGCTGGTCTTCATAGTCCTGGCTGAGCACTACAAGGTGGTGGTAAATGGAAATCCC
TTCTATGAGTACGGGCACCGGCTTCCCCTACAGATGGTCACCCACCTGCAAGTGGATGGG
GATCTGCAACTTCAATCAATCAACTTCATCGGAGGCCAGCCCCTCCGGCCCCAGGGACCC
CCGATGATGCCACCTTACCCTGGTCCCGGACATTGCCATCAACAGCTGAACAGCCTGCCC
ACCATGGAAGGACCCCCAACCTTCAACCCGCCTGTGCCATATTTCGGGAGGCTGCAAGGA
GGGCTCACAGCTCGAAGAACCATCATCATCAAGGGCTATGTGCCTCCCACAGGCAAGAGC
TTTGCTATCAACTTCAAGGTGGGCTCCTCAGGGGACATAGCTCTGCACATTAATCCCCGC
ATGGGCAACGGTACCGTGGTCCGGAACAGCCTTCTGAATGGCTCGTGGGGATCCGAGGAG
AAGAAGATCACCCACAACCCATTTGGTCCCGGACAGTTCTTTGATCTGTCCATTCGCTGT
GGCTTGGATCGCTTCAAGGTTTACGCCAATGGCCAGCACCTCTTTGACTTTGCCCATCGC
CTCTCGGCCTTCCAGAGGGTGGACACATTGGAAATCCAGGGTGATGTCACCTTGTCCTAT
GTCCAGATCTAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
AB006781

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:19

# Macromolecular_Interacting_Partner_1_Locus:
19q13.2

# Macromolecular_Interacting_Partner_1_SNPs:
rs8106404; rs1035524; rs8113319; rs7250734; rs1035525; rs4802887; rs4802888; rs4375781; rs12463099; rs12610990; rs10775532; rs12460812; rs8111357; rs7507803; rs12977453; rs2052569; rs4802886; rs4575642; rs12972114; rs10404489; rs10417292; rs12461466; rs884299; rs10403583; rs35631131; rs10441; rs4575640; rs34677297; rs11670263; rs3993040; rs10423776; rs11881973; rs10084119; rs2403781; rs3745866; rs2403782; rs10414466; rs35490470; rs2403780; rs5828018; rs34382537; rs11319100; rs4575641; rs34812797; rs34820201; rs35520148; rs10531431; rs3076964; rs4254434; rs3898955; rs7507286; rs28405800; rs4802890; rs35905844; rs12460580; rs10423065; rs10424620; rs10426289; rs1064972; rs1078733; rs1078734; rs10967; rs11669239; rs12980315; rs2017784; rs2075587; rs2075588; rs2229259; rs2229260; rs2287952; rs2287953; rs2287954; rs2303172; rs7247185; rs889327; rs9749397

# Macromolecular_Interacting_Partner_1_General_References:
9310382; 9162064

# Macromolecular_Interacting_Partner_1_References:
2944111; 6092916

End of HMDB00048

Beginning of HMDB00050
# Accession_No:
HMDB00050

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-16 13:04:10

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Adenosine

# Description:
A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. For instance, adenosine plays an important role in energy transfer - as adenosine triphosphate (ATP) and adenosine diphosphate (ADP).  It also plays a role in signal transduction as cyclic adenosine monophosphate, cAMP. Adenosine itself is both a neurotransmitter and potent vasodilator. When administered intravenously, adenosine causes transient heart block in the AV node. Because of the effects of adenosine on AV node-dependent supraventricular tachycardia, adenosine is considered a class V antiarrhythmic agent.

# Synonyms:
1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-beta-D-Arabinofuranosyladenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-d-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine; 9beta-D-ribofuranosyl-9H-Purin-6-amine; Adenine nucleoside; Adenine riboside; Adenocard; Adenocor; Adenoscan; Adenosin; Boniton; Myocol; Nucleocardyl; Sandesin; adenine-9beta-D-Ribofuranoside; b-D-Adenosine; beta-Adenosine; 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose; 6-Amino-9beta-delta-ribofuranosyl-9H-purine; 9-beta-delta-Arabinofuranosyladenine; 9-beta-delta-Ribofuranosidoadenine; 9-beta-delta-Ribofuranosyl-9H-purin-6-amine; 9-beta-delta-Ribofuranosyladenine; 9beta-delta-Ribofuranosyladenine; 9beta-delta-ribofuranosyl-9H-Purin-6-amine; adenine-9beta-delta-Ribofuranoside; beta-delta-Adenosine; beta-D-Adenosine

# Chemical_IUPAC_Name:
2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

# Chemical_Formula:
C10H13N5O4

# Chemical_Structure:
tbl_chemical:::HMDB00050_ZOOM.png:::119283155504229090

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00050_THUMB.png:::119283155300386636

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Purines; Pyrimidines

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
hemiaminal; primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Methionine metabolism; Component of Purine metabolism; Component of Selenoamino acid metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
267.09674

# Molecular_Weight_Avg:
267.24130

# Smiles_String_isomeric:
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

# Smiles_String_canonical:
NC1=NC=NC2=C1N=CN2C3OC(CO)C(O)C3O

# KEGG_Compound_ID:
C00212

# BioCyc_ID:
ADENOSINE

# PubChem_CID:
60961

# PubChem_SID:
828107; 197179; 597013; 825728; 11371396; 3512; 828519; 836875; 823399; 829493; 8027269; 837192; 821994; 11121293; 835338; 584490; 823450; 8023217; 11532674; 3136392; 7847113; 11489073; 584484; 585862; 12090919; 855932; 586357; 11120805; 7853711; 830178; 829606; 7978645; 207362; 11537606; 855078; 11490104; 825158; 833907; 830391; 10318629; 8143428; 11120317; 8187141; 823447; 8024149; 833174; 10322211; 826920; 11484930; 11532406; 819854; 836140; 11110168; 7885717

# OMIM_ID:
102800; 603005

# Metagene_ID:
ADENYLOSUCCINASE DEFICIENCY: 362

# BiGG_ID:
34273

# Wikipedia_ID:
Adenosine

# METLIN_ID:
86

# Ref_ID:
16178799; 15882454; 15116424; 16181820; 16177794; 16181825; 7686877; 15028034; 9869364; 6656991; 16177183; 12927681; 15455468

# ChEBI_ID:
16335

# CAS_Registry_Number:
58-61-7

# InChI:
InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

# Synthesis_Reference:
Ribonucleoside 2',3'-cyclic orthoformates.     Jarman, M.; Reese, C. B.    Univ. Chem. Lab.,  Cambridge,  UK.    Chemistry & Industry (London, United Kingdom)  (1964),   (34),  1493-4.

# Melting_Point:
235.5 oC

# Melting_Point_predicted:
Not Available

# H2O_Solubility_Experimental:
7 mg/mL [Adenocard product monograph]; 37 mg/mL [HMP experimental]

# H2O_Solubility_Predicted:
8.23 mg/mL [MEYLAN,WM et al. (1996)]; 14.0 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
-1.05 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
-1.20 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Adenosine.htm:::1132562193449225054

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Adenosine.mol:::1132723803578811236

# SDF_File_[Text]:
tbl_chemical:::HMDB00050.sdf:::119283154839856646

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00050.pdb:::119283155127237773

# PDB_ID:
1BX4

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1BX4.txt:::1132720900171985498

# H_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_PRESAT_expanded_2.gif:::114168246185697527

# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_presat.zip:::1177710570027581246

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
tbl_hnmrw:::041007_P00_01_HW_1DP_Assigned.png:::117821566747616295

# H_NMR_Spectra_Sykes:
tbl_hnmrs:::041007_P00_01_HW_1DP_presat.png:::114850660506710030

# H_NMR_FIDS_Spectra_Sykes:
tbl_hnmrs:::041007_P00_01_HW_1DP_presat.zip:::11485064510489875

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:


# C_NMR_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85.jpg:::114168476639054407

# C_NMR_FIDS_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85.zip:::114168476635519197

# C_NMR_Instrument_Manufacturer:
Bruker

# Assignemnt_For_CNMR_Spectra:
tbl_cnmr:::041007_P00_01_HW_1DC_85_Assigned.jpg:::115895131029442845

# 2D_HSQC_Spectra:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43.jpg:::114617547584867838

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43.zip:::114617547585952726

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::041007_P00_01_HW_2DHSQC_43_Assigned.jpg:::115895136188469363

# Predicted_H_NMR_Spectrum:
tbl_chemical:::adenosine.gif:::1132732102593132630

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00050_peaks.txt:::1156309510107736284

# Predicted_C_NMR_Spectrum:
tbl_chemical:::adenosine_C.gif:::1132737667071532436

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00050_peaks.txt:::115631070167940569

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00050L.png:::117555261872171441; Medium Energy:tbl_ms:::HMDB00050M.png:::117555267005464975; High Energy:tbl_ms:::HMDB00050H.png:::117555270873196920

# Simplied_Tocsy_Spectrum:
tbl_tocsy:::TOCSY_Synthetic_000061.png:::116899930860982513

# Simplied_Tocsy_Peaklist:
tbl_tocsy:::TOCSY_Synthetic_000061.txt:::116899930860929782

# BMRB_Spectrum:
tbl_tocsy:::TOCSY_Experimental_000061.png:::116890825214023014

# BMRB_Peaklist:
tbl_tocsy:::TOCSY_Experimental_000061.txt:::116890825242192968

# Cellular_Location:
Cytoplasm (Predicted from LogP); Extracellular; lysosome; mitochondria

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Cellular Cytoplasm; Urine

# Concentration_[Normal]:
Urine	4.7+/-7.0	umol/mmol_creatinine	Adult:>18_yrs_old	N/A	Normal	12927681
Urine	17.5+/-14.6	umol/mmol_creatinine	Children:1-13_yrs_old	N/A	Normal	12927681
Urine	0.50 (0.09-0.92)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	15116424
Blood	0.2 (0.1-0.3)	umol/L	Adult:>18_yrs_old	Both	Normal	6656991
Blood	0.025(0-0.050)	umol/L	Adult:>18_yrs_old	Both	Normal	17172976
Blood	0.31 +/- 0.29	uM	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Cerebrospinal_Fluid(CSF)	0.01 +/- 0.002	umol/L	Adult:>18_yrs_old	N/A	Normal	15028034
Cerebrospinal_Fluid(CSF)	0 - 0.1	uM	Adult:>18_yrs_old	Both	Normal	6656991
Cellular_Cytoplasm	1.20 (0.90-1.50)	umol/L	Adult:>18_yrs_old	Both	Normal	15882454


# Concentration_[Abnormal]:
Urine	1.33	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Adenosine Deaminase (ADA) Deficiency	9869364
Blood	0.114 (0-0.228)	umol/L	Adult:>18_yrs_old	Both	Patients with septic shock	17172976


# Associated_Disorders:
Adenosine Deaminase (ADA) Deficiency; Asthma; Cachexia; Hyperhomocysteinemia; Immunodeficiency; Neurally Mediated Syncope; Patients with septic shock

# Pathway_Names:
Purine metabolism;Nicotinate and nicotinamide metabolism;Methionine metabolism

# Pathway_Images:
Purine_Synthesis.jpg;Nicotinamide_synthesis_(NADH).jpg;Methionine_Metabolism.jpg

# KEGG_Images:
map00230;map00760;map00271

# Pathway_Graphs:
Purine_Synthesis_Graph.jpg;Nicotinamide_synthesis_(NADH)_Graph.jpg;Methionine_Metabolism_Graph.jpg

# Pathway_SBMLs:
Purine_Synthesis.xml;Nicotinamide_synthesis_(NADH).xml;Methionine_Metabolism.xml

# Metabolic_Enzyme_1_ID:
5237

# Metabolic_Enzyme_1_Name:
Cytosolic purine 5'-nucleotidase

# Metabolic_Enzyme_1_Synonyms:
5'-nucleotidase cytosolic II

# Metabolic_Enzyme_1_Gene_Name:
NT5C2

# Metabolic_Enzyme_1_Protein_Sequence:
>Cytosolic purine 5'nucleotidase
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEEE

# Metabolic_Enzyme_1_Number_of_Residues:
561

# Metabolic_Enzyme_1_Molecular_Weight:
64970

# Metabolic_Enzyme_1_Theoretical_pI:
6.05

# Metabolic_Enzyme_1_GO_Classification:
Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides

# Metabolic_Enzyme_1_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_1_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF05761:5_nucleotid

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
633071

# Metabolic_Enzyme_1_SwissProt_ID:
5NTC_HUMAN (P49902)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
NT5C2

# Metabolic_Enzyme_1_Geneatlas_id:
NT5C2

# Metabolic_Enzyme_1_hgnc_id:
HGNC:8022

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>1686 bp
ATGTCGACCTCCTGGAGTGATCGGTTACAGAATGCAGCAGATATGCCTGCTAACATGGAT
AAGCATGCCCTGAAAAAGTATCGTCGAGAAGCCTATCATCGGGTGTTTGTGAACCGAAGT
TTAGCAATGGAAAAGATAAAGTGTTTTGGTTTTGATATGGATTATACCCTTGCTGTGTAC
AAGTCCCCAGAGTATGAGTCCCTTGGTTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCCCAGGAGTTGCTCAGCTTTGCTTATGATTCTACATTCCCTACCAGGGGACTT
GTCTTTGACACACTGTATGGAAATCTTTTGAAAGTCGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTTATAAGGGGACCAGAAACTAGAGAACAGTATCCAAATAAA
TTTATCCAGCGAGATGATACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATATACCAGT
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCCTACCGGAGTATGTTCCAGGAT
GTAAGAGATGCTGTTGACTGGGTTCATTACAAGGGCTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGGAAAGTATTTCTTGCTACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGACTTCCCACATGGCCCCAAGCCTGGGAGCTCCCATCGACCATGGCAG
TCCTACTTTGACTTGATCTTGGTGGATGCACGGAAACCACTCTTTTTTGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACAGGGCCC
CTACAGCATGGTATCGTCTACTCAGGAGGTTCTTCTGATACGATCTGTGACCTGTTGGGA
GCCAAGGGAAAAGACATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTTTTGGTGATTCCTGAACTCGCACAGGAGCTACAT
GTCTGGACTGACAAGAGTTCACTTTTCGAAGAACTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCATCTTGACAGCAGTAGCAATGAGCGTCCAGACATCAGTTCCATCCAG
AGACGTATTAAGAAAGTAACTCATGACATGGACATGTGCTATGGGATGATGGGAAGCCTG
TTTCGCAGTGGCTCCCGGCAGACCCTTTTTGCCAGTCAAGTGATGCGTTATGCTGACCTC
TATGCAGCATCTTTCATCAACCTGCTGTATTACCCTTTCAGCTACCTCTTCAGGGCTGCC
CATGTCTTGATGCCTCATGAATCAACGGTGGAGCACACACACGTAGATATCAATGAGATG
GAGTCTCCTCTTGCCACCCGGAACCGCACATCAGTGGATTTCAAAGACACTGACTACAAG
CGGCACCAGCTGACACGGTCAATTAGTGAGATTAAACCTCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAAGAGGAGGAGGAGGAGGAA
GAATAA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
D38524

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_1_Locus:
10q24.32-q24.33

# Metabolic_Enzyme_1_SNPs:
rs12262171; rs3740387; rs12253627; rs10786736; rs8139; rs7917650; rs10786741; rs7920251; rs10430665; rs7916854; rs12573199; rs11191598; rs1163238; rs12573200; rs10883843; rs7092407; rs12573221; rs4917997; rs11191593; rs11191596; rs10786744; rs1163236; rs10883842; rs10786742; rs10786743; rs7075552; rs7077097; rs2863728; rs3758543; rs7077291; rs10748838; rs3087681; rs12240508; rs732998; rs10883830; rs7899084; rs2274340; rs2182348; rs2066322; rs7908960; rs7912517; rs7067970; rs3740386; rs7896547; rs11191554; rs1163249; rs2281877; rs2863727; rs3781281; rs2274341; rs2148198; rs7897663; rs3781282; rs10883832; rs1926029; rs1935323; rs1926030; rs746293; rs6584539; rs2066323; rs9919482; rs3740385; rs12773916; rs12414232; rs10786737; rs12413046; rs12412038; rs2274339; rs11598702; rs1541213; rs11191580; rs11191553; rs10509765; rs10509766; rs3977751; rs12220375; rs4917996; rs7896433; rs6584540; rs1926037; rs3736922; rs11191577; rs2148197; rs11191561; rs7080935; rs11191555; rs10883833; rs12219304; rs1926036; rs7913920; rs10883834; rs11191558; rs11191582; rs11191589; rs10883831; rs12220743; rs10786738; rs11191560; rs10748837; rs11191578; rs3781280; rs7896519; rs12217501; rs11191573; rs7067741; rs6584541; rs7067663; rs2148200; rs10883840; rs11191583; rs12415199; rs9919485; rs11191557; rs17094683; rs7895154; rs12355120; rs2153774; rs10786739; rs7915816; rs7081075; rs1807298; rs3861984; rs11191572; rs12571568; rs12416331; rs11191586; rs10883839; rs12766205; rs1163239; rs10883837; rs11191584; rs1163247; rs17115452; rs11191556; rs7909022; rs12775302; rs9633712; rs11191581; rs11191576; rs10883836; rs11191549; rs7095304; rs10883845; rs11191550; rs11191548; rs11191602; rs10748839; rs1141101; rs1055812; rs1141100; rs1141098; rs1141099; rs34351688; rs34394526; rs34058246; rs11191594; rs35224704; rs34747231; rs12774207; rs11191595; rs34699185; rs11280184; rs1163237; rs7073259; rs34064597; rs11191601; rs35525740; rs35291480; rs12264098; rs35978588; rs12241986; rs7091462; rs12774182; rs34756486; rs35695488; rs12252236; rs3834416; rs11191600; rs34136949; rs7080242; rs12763243; rs34003851; rs11191585; rs11191551; rs36111455; rs34966121; rs35464534; rs35541240; rs11191571; rs35913488; rs34223002; rs11440429; rs41287482; rs35653865; rs34963818; rs11191559; rs11191568; rs35436872; rs17795366; rs1163246; rs34060908; rs34963563; rs34915846; rs12780509; rs2153773; rs34211645; rs3736924; rs34758128; rs36059537; rs35302704; rs12255989; rs34104646; rs11191574; rs11191564; rs35745742; rs34644789; rs5787481; rs34863357; rs11191590; rs12774840; rs2148196; rs12763944; rs3215816; rs34207290; rs35752695; rs34445719; rs28419708; rs4421684; rs28516969; rs12265498; rs12767422; rs12772228; rs34908445; rs11191570; rs17115449; rs35195396; rs12243923; rs10883835; rs12779263; rs11302933; rs7091173; rs11375439; rs7071103; rs35146429; rs35338839; rs34268365; rs34130454; rs35898850; rs3861983; rs28404041; rs35621207; rs3736923; rs5787482; rs7075048; rs34307431; rs35348020; rs34349473; rs1773930; rs11191566; rs34870452; rs35078544; rs35123178; rs12265545; rs1163241; rs3949893; rs7904067; rs12775841; rs35821867; rs12775904; rs7915032; rs5028036; rs35254502; rs1163248; rs35365027; rs34876862; rs11191565; rs12772280; rs10709724; rs35085852; rs35351555; rs12774513; rs10710371; rs11296588; rs12243903; rs28605898; rs34241930; rs34549427; rs11451961; rs34403968; rs12761657; rs34397864; rs3062737; rs36092020; rs35109679; rs34011916; rs34435560; rs11191562; rs4917383; rs34067380; rs34202831; rs11191563; rs2148199; rs34133379; rs35763505; rs12414385; rs1163240; rs12262258; rs11191588; rs34664715; rs12414374; rs35133717; rs3837340; rs10614009; rs2153772; rs11191587; rs11403586; rs11191575; rs1060240; rs34588165; rs11191552; rs41317254; rs1163245; rs1064099; rs12268552; rs34833988; rs11191603; rs12253716; rs12412924; rs3841710; rs34551510; rs12246784; rs12781668; rs1064098; rs10458729; rs10786740; rs10786745; rs10883829; rs10883841; rs11191547; rs1163235; rs12261294; rs12571345; rs12785223; rs17115427; rs4307650; rs4917382; rs4917995; rs7074395; rs7092200; rs726010; rs763914; rs7921996; rs943035

# Metabolic_Enzyme_1_General_References:
7999131

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5933

# Metabolic_Enzyme_2_Name:
Putative adenosylhomocysteinase 3

# Metabolic_Enzyme_2_Synonyms:
S-adenosyl-L- homocysteine hydrolase 3; AdoHcyase 3

# Metabolic_Enzyme_2_Gene_Name:
KIAA0828

# Metabolic_Enzyme_2_Protein_Sequence:
>Putative adenosylhomocysteinase 3
MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPPAGGGDPEAPAPAAERP
PVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVK
KQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNS
KGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTA
VLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVE
GWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVN
DSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYV
TEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGH
SNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITA
TTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNK
NGPFKPNYYRY

# Metabolic_Enzyme_2_Number_of_Residues:
611

# Metabolic_Enzyme_2_Molecular_Weight:
66722

# Metabolic_Enzyme_2_Theoretical_pI:
7.39

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_2_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_2_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
4240145

# Metabolic_Enzyme_2_SwissProt_ID:
SAHH3_HUMAN (Q96HN2)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
Not Available

# Metabolic_Enzyme_2_Geneatlas_id:
Not Available

# Metabolic_Enzyme_2_hgnc_id:
Not Available

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>1860 bp
GAGCCGGTGGTTGCAGCGGAGGCGGTGATGTCGGTGCAGGTTGTGTCAGCCGCGGCTGCC
GCCAAGGTGCCTGAGGTGGAGCTGAAGGACCTGAGCCCCTCCGAGGCGGAGTCGCAACTA
GGACTGAGCACGGCCGCCGTGGGCGCCATGGCCCCCCCGGCGGGCGGTGGAGACCCTGAG
GCTCCAGCTCCCGCCGCGGAGCGGCCCCCGGTCCCCGGCCCGGGCTCGGGGCCCGCCGCC
GCTCTCAGCCCCGCCGCCGGGAAGGTGCCTCAGGCGTCGGCCATGAAGCGGAGCGACCCA
CATCACCAGCACCAGCGGCACCGCGACGGCGGCGAGGCCCTGGTCAGCCCCGACGGCACC
GTCACCGAGGCGCCGCGCACAGTCAAGAAGATCCAGTTTGCTGACCAGAAGCAAGAATTC
AACAAACGTCCCACCAAAATTGGACGTCGCTCTTTGTCTCGTTCCATTTCTCAGTCATCT
ACTGACAGCTACAGCTCAGCGGCTTCATATACAGATAGCTCTGATGATGAGACATCGCCC
AGGGACAAGCAGCAAAAGAACTCTAAGGGAAGCAGTGACTTCTGTGTTAAGAACATCAAA
CAGGCAGAGTTTGGACGAAGAGAAATTGAAATTGCTGAACAAGAAATGCCTGCATTGATG
GCTTTGAGGAAGAGAGCTCAAGGAGAAAAGCCTTTGGCTGGAGCCAAAATCGTGGGTTGC
ACACACATCACTGCTCAGACTGCTGTGCTTATGGAAACTCTGGGTGCTCTGGGGGCCCAG
TGCCGATGGGCTGCCTGCAACATCTATTCCACTCTCAATGAAGTGGCTGCTGCTCTAGCA
GAAAGTGGATTTCCTGTTTTTGCCTGGAAGGGAGAGTCAGAAGATGACTTTTGGTGGTGT
ATCGATAGATGTGTGAATGTGGAGGGCTGGCAGCCAAACATGATCTTGGATGATGGAGGG
GATCTTACCCACTGGATTTATAAAAAGTATCCCAACATGTTTAAGAAAATCAAGGGCATA
GTAGAGGAGAGTGTTACTGGAGTTCACAGGCTGTACCAACTGTCCAAAGCTGGGAAGCTG
TGTGTTCCAGCCATGAATGTCAATGACTCAGTCACCAAACAGAAATTTGACAACCTCTAC
TGTTGCCGTGAATCAATTCTTGATGGACTTAAAAGGACAACAGACATGATGTTTGGTGGA
AAGCAAGTGGTAGTCTGTGGCTATGGAGAGGTGGGGAAAGGGTGCTGTGCTGCCCTGAAA
GCCATGGGCTCCATTGTGTATGTAACTGAAATTGACCCCATCTGTGCCCTGCAAGCCTGT
ATGGATGGATTTCGACTGGTGAAATTAAATGAGGTCATCCGACAAGTGGACATTGTTATT
ACCTGTACAGGTAACAAGAATGTGGTAACCAGAGAGCACTTGGACCGTATGAAGAATAGC
TGCATCGTTTGTAACATGGGACATTCCAACACAGAGATTGACGTGGCGAGTCTGCGGACA
CCAGAACTGACCTGGGAGCGAGTGAGATCTCAAGTTGACCATGTGATATGGCCTGATGGC
AAGAGGATAGTACTGCTGGCAGAGGGCCGCCTGCTGAACCTTAGCTGCTCCACAGTGCCT
ACATTTGTGCTCTCAATCACTGCTACTACTCAGGCTCTTGCCTTGATAGAGCTTTACAAT
GCTCCTGAGGGTCGCTATAAGCAGGATGTCTACCTGTTGCCCAAGAAGATGGATGAGTAT
GTGGCCAGCCTACACCTGCCTACCTTTGATGCCCACTTGACAGAGCTGACAGATGAACAG
GCCAAGTATCTGGGACTCAACAAGAATGGGCCCTTCAAGCCTAATTACTACAGGTATTAA


# Metabolic_Enzyme_2_GenBank_ID_Gene:
AB020635

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7q32.1

# Metabolic_Enzyme_2_SNPs:
rs4731575; rs4728164; rs1665105; rs12112383; rs1473236; rs1559486; rs1880854; rs2141075; rs2694572; rs822040; rs4731572; rs2718091; rs3734969; rs9641846; rs822038; rs6467240; rs6467233; rs891545; rs2566876; rs2718090; rs6953598; rs1000676; rs2718084; rs2402951; rs6467237; rs1526899; rs10954226; rs2012919; rs6969620; rs2402944; rs7794622; rs1541711; rs2896414; rs4728163; rs4731570; rs2566882; rs12667132; rs2694591; rs1526898; rs2718097; rs6966595; rs2896415; rs6974155; rs1609043; rs6467243; rs6467239; rs12540568; rs1526900; rs10248810; rs7800983; rs822039; rs2566879; rs17348939; rs17628482; rs6950279; rs11979476; rs6947322; rs10954231; rs9641849; rs7788327; rs10954227; rs1549788; rs2694570; rs2402945; rs2718100; rs17627941; rs17427959; rs2694574; rs7805353; rs4110091; rs13235749; rs12668958; rs7792317; rs6948252; rs2694585; rs11762085; rs2402947; rs10954230; rs2566885; rs10257620; rs6967464; rs6971917; rs4517061; rs7781902; rs17168214; rs6467241; rs2694576; rs6467236; rs974558; rs10954229; rs12534372; rs2566875; rs11773220; rs6949882; rs6980385; rs4731568; rs13245719; rs2718114; rs2566877; rs2303303; rs7789697; rs2566887; rs6467235; rs2718083; rs4731569; rs17552570; rs17552411; rs10249336; rs3928439; rs2718099; rs10954228; rs4338039; rs2718093; rs2718096; rs2103232; rs1991645; rs963465; rs9641847; rs17168734; rs6946288; rs9641850; rs7811141; rs6467234; rs12706872; rs11766298; rs2718085; rs9641851; rs1405475; rs10281269; rs10235589; rs10264209; rs2718089; rs2718086; rs10224011; rs17168750; rs12706879; rs10954224; rs12535502; rs12536256; rs9770833; rs4731567; rs12532192; rs7780886; rs13240723; rs2056694; rs17168512; rs6949950; rs7806089; rs7782348; rs11983827; rs10269495; rs13228005; rs2718098; rs6946270; rs7779572; rs7787531; rs10215998; rs10480492; rs13240872; rs11771587; rs4731571; rs2694589; rs4731566; rs2694586; rs7799667; rs12671820; rs2566881; rs721691; rs2694583; rs6944095; rs6946938; rs9649531; rs12154376; rs10255583; rs13235047; rs12706878; rs12112374; rs13243361; rs4460316; rs2463096; rs13225516; rs6953498; rs12706877; rs2718094; rs6958637; rs2718115; rs4440569; rs35381790; rs35695777; rs4728162; rs13226919; rs12536259; rs17168678; rs6944100; rs2402943; rs6942756; rs10237796; rs13246455; rs11770643; rs12533108; rs36033343; rs12706884; rs974557; rs10248733; rs6467242; rs2566878; rs9649530; rs2402946; rs7778993; rs7803052; rs10271956; rs2056693; rs2566883; rs2694571; rs2694590; rs12706880; rs1526897; rs11760275; rs10249742; rs2718088; rs13228930; rs4731565; rs1043148; rs1446314; rs34265960; rs2566884; rs34825108; rs13234716; rs5887417; rs10276667; rs13237450; rs35486062; rs2718092; rs13236141; rs11763340; rs10526470; rs13244886; rs2694584; rs12056066; rs35386880; rs10583733; rs12706873; rs35552948; rs2703097; rs28637615; rs35302708; rs35043755; rs5887423; rs35771438; rs35183043; rs10537645; rs2694578; rs13243489; rs13309956; rs9649533; rs35285871; rs35645930; rs11765453; rs13245699; rs35678215; rs34402215; rs34357178; rs10224918; rs34069719; rs11440633; rs35253341; rs34419391; rs5887420; rs2718117; rs13227401; rs34545127; rs13229264; rs2566889; rs34134186; rs2694588; rs11766893; rs34119954; rs36016296; rs13236139; rs9640854; rs34748419; rs35525446; rs11457350; rs13235721; rs34103750; rs12111832; rs34470956; rs13230585; rs2566880; rs34454055; rs34022136; rs13241934; rs13236035; rs35506900; rs10661940; rs13243483; rs10689917; rs10268256; rs13229015; rs34284898; rs35056717; rs13235668; rs34946923; rs35487046; rs35382981; rs10276901; rs12706881; rs12154848; rs7779327; rs35611732; rs10650322; rs35922521; rs34721141; rs6942616; rs2694577; rs13240434; rs11769045; rs34114985; rs6467238; rs10245502; rs35477492; rs11323551; rs35891284; rs35236990; rs12706874; rs13228836; rs10273064; rs34878710; rs28636722; rs35464810; rs34778910; rs2303304; rs34534484; rs35305688; rs13309724; rs35753023; rs13242624; rs34545652; rs35837581; rs35886223; rs35060087; rs28475451; rs36065880; rs9692086; rs2718116; rs34535486; rs35730873; rs28772714; rs12671819; rs35687709; rs10573827; rs34729253; rs13224964; rs34387388; rs3993423; rs34329339; rs35555009; rs35604507; rs12155238; rs10245510; rs13230006; rs35749606; rs13247394; rs5887419; rs35300462; rs34626657; rs2718095; rs34656052; rs34836433; rs35160763; rs35499576; rs35753672; rs35180865; rs10245484; rs13227798; rs35366945; rs36047105; rs35575921; rs1469554; rs34184431; rs34634565; rs34605112; rs35543406; rs34783919; rs13235827; rs34936807; rs34129720; rs34698607; rs10628531; rs7808914; rs10276656; rs34218104; rs5887416; rs10261099; rs34829322; rs34995893; rs35720899; rs4460315; rs34985505; rs35068503; rs34969591; rs13242524; rs34944147; rs34203815; rs4579470; rs13221770; rs13242637; rs5887425; rs12706882; rs2694573; rs11352933; rs13239013; rs13230002; rs35239026; rs34807363; rs34015816; rs28421993; rs35562807; rs12706883; rs34691806; rs13247573; rs3993422; rs6970267; rs2718113; rs35974655; rs36058920; rs34048833; rs11298188; rs34168159; rs13228824; rs34883234; rs1074590; rs35351067; rs4605985; rs34797175; rs35412146; rs11428994; rs35450194; rs13236334; rs7778277; rs13242723; rs34911717; rs10267792; rs34651338; rs11373631; rs7802713; rs34822917; rs35195965; rs34025224; rs12706870; rs28786973; rs28399138; rs1562290; rs13235928; rs4339576; rs34323262; rs35035148; rs35801870; rs35071037; rs34986300; rs2566888; rs5887426; rs35525239; rs7806246; rs10682674; rs35521435; rs2263406; rs11353507; rs10281707; rs11763056; rs1918166; rs35797517; rs11411466; rs36071728; rs34546094; rs10261662; rs34867290; rs11766497; rs11371543; rs11384557; rs35710833; rs35091143; rs34806898; rs7802714; rs13226007; rs9641848; rs34625300; rs13226649; rs36037913; rs5887415; rs36113794; rs34355222; rs10527531; rs36058039; rs13238821; rs28437865; rs11407963; rs28616609; rs35743744; rs12706875; rs35097530; rs6962787; rs34118673; rs12533541; rs11389356; rs35051098; rs2703095; rs10232890; rs11379395; rs34643315; rs34890000; rs34694658; rs35404531; rs7810723; rs34806455; rs34026893; rs35866593; rs10247803; rs11414828; rs5887424; rs11763325; rs35779079; rs34064858; rs12667455; rs2694575; rs2718112; rs34783708; rs10271957; rs11765864; rs34971920; rs34629871; rs11772187; rs35064108; rs3887099; rs36005479; rs4731573; rs2718101; rs13229872; rs36093290; rs9690544; rs34481793; rs35136112; rs10579412; rs35082865; rs35467311; rs13227656; rs10954225; rs7790641; rs13245810; rs33989909; rs34809861; rs34696153; rs3042852; rs35443669; rs12216567; rs35120382; rs13310010; rs34422629; rs34853082; rs34659337; rs35907574; rs10245503; rs2141074; rs34071272; rs11319368; rs13242529; rs972568; rs11375520; rs36100832; rs34285950; rs4731574; rs13242604; rs35756110; rs13241894; rs34071868; rs7808920; rs35775278; rs2566886; rs34100080; rs34134934; rs34719441; rs12706876; rs35640675; rs1918167; rs35859186; rs35654453; rs10653631; rs35112509; rs35782004; rs11975133; rs12248; rs35714254; rs4728160; rs587499; rs6467244; rs682299; rs691807; rs692686; rs6971551; rs6977752

# Metabolic_Enzyme_2_General_References:
10048485

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5934

# Metabolic_Enzyme_3_Name:
Adenosylhomocysteinase

# Metabolic_Enzyme_3_Synonyms:
S-adenosyl-L-homocysteine hydrolase; AdoHcyase

# Metabolic_Enzyme_3_Gene_Name:
AHCY

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenosylhomocysteinase
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY

# Metabolic_Enzyme_3_Number_of_Residues:
432

# Metabolic_Enzyme_3_Molecular_Weight:
47717

# Metabolic_Enzyme_3_Theoretical_pI:
6.29

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

# Metabolic_Enzyme_3_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_3_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
178277

# Metabolic_Enzyme_3_SwissProt_ID:
SAHH_HUMAN (P23526)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
AHCY

# Metabolic_Enzyme_3_Geneatlas_id:
AHCY

# Metabolic_Enzyme_3_hgnc_id:
HGNC:343

# Metabolic_Enzyme_3_PDB_ID:
1LI4

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

# Metabolic_Enzyme_3_Gene_Sequence:
>1299 bp
ATGTCTGACAAACTGCCCTACAAAGTCGCCGACATCGGCCTGGCTGCCTGGGGACGCAAG
GCCCTGGACATTGCTGAGAACGAGATGCCGGGCCTGATGCGTATGCGGGAGCGGTACTCG
GCCTCCAAGCCACTGAAGGGCGCCCGCATCGCTGGCTGCCTGCACATGACCGTGGAGACG
GCCGTCCTCATTGAGACCCTCGTCACCCTGGGTGCTGAGGTGCAGTGGTCCAGCTGCAAC
ATCTTCTCCACCCAGAACCATGCGGCGGCTGCCATTGCCAAGGCTGGCATTCCGGTGTAT
GCCTGGAAGGGCGAAACGGACGAGGAGTACCTGTGGTGCATTGAGCAGACCCTGTACTTC
AAGGACGGGCCCCTCAACATGATTCTGGACGACGGGGGCGACCTCACCAACCTCATCCAC
ACCAAGTACCCGCAGCTTCTGCCAGGCATCCGAGGCATCTCTGAGGAGACCACGACTGGG
GTCCACAACCTCTACAAGATGATGGCCAATGGGATCCTCAAGGTGCCTGCCATCAATGTC
AATGACTCCGTCACCAAGAGCAAGTTTGACAACCTCTATGGCTGCCGGGAGTCCCTCATA
GATGGCATCAAGCGGGCCACAGATGTGATGATTGCCGGCAAGGTAGCGGTGGTAGCAGGC
TATGGTGATGTGGGCAAGGGCTGTGCCCAGGCCCTGCGGGGTTTCGGAGCCCGCGTCATC
ATCACCGAGATTGACCCCATCAACGCACTGCAGGCTGCCATGGAGGGCTATGAGGTGACC
ACCATGGATGAGGCCTGTCAGGAGGGCAACATCTTTGTCACCACCACAGGCTGTATTGAC
ATCATCCTTGGCCGGCACTTTGAGCAGATGAAGGATGATGCCATTGTGTGTAACATTGGA
CACTTTGACGTGGAGATCGATGTCAAGTGGCTCAACGAGAACGCCGTGGAGAAGGTGAAC
ATCAAGCCGCAGGTGGACCGGTATCGGTTGAAGAATGGGCGCCGCATCATCCTGCTGGCC
GAGGGTCGGCTGGTCAACCTGGGTTGTGCCATGGGCCACCCCAGCTTCGTGATGAGTAAC
TCCTTCACCAACCAGGTGATGGCGCAGATCGAGCTGTGGACCCATCCAGACAAGTACCCC
GTTGGGGTTCATTTCCTGCCCAAGAAGCTGGATGAGGCAGTGGCTGAAGCCCACCTGGGC
AAGCTGAATGTGAAGTTGACCAAGCTAACTGAGAAGCAAGCCCAGTACCTGGGCATGTCC
TGTGATGGCCCCTTCAAGCCGGATCACTACCGCTACTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M61831

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20cen-q13.1

# Metabolic_Enzyme_3_SNPs:
rs13043752; rs4239; rs13245; rs35913265; rs819134; rs819147; rs864702; rs819159; rs7271501; rs866027; rs1205357; rs819155; rs6059756; rs1205352; rs1205366; rs819156; rs819158; rs819148; rs819157; rs17091705; rs819133; rs17091729; rs17091701; rs11906980; rs6059755; rs819151; rs4456777; rs3838022; rs6119486; rs1205354; rs17091698; rs819150; rs875650; rs35351212; rs17091693; rs819132; rs1205355; rs1205356; rs34602355; rs7273572; rs34906237; rs819171; rs819169; rs819175; rs819173; rs819146; rs819172; rs843902; rs819174; rs1093782; rs1093783; rs11552694; rs41312290; rs41301825; rs11552700; rs11552699; rs6088457; rs11552697; rs11552698; rs6058020; rs12506; rs3208589; rs3208572; rs1064500; rs35627251; rs1058794; rs1058802; rs14941; rs35038733; rs819154; rs34623965; rs11475294; rs6058019; rs819149; rs34897875; rs11479058; rs6119488; rs35828873; rs35598784; rs5841170; rs13036766; rs33975173; rs34804525; rs34481238; rs6142135; rs6120597; rs6088456; rs819152; rs41310000; rs6120599; rs6059753; rs34988314; rs11697391; rs819153; rs6141460; rs6119487; rs6141459; rs6142133; rs6059752; rs7354522; rs34053088; rs34858306; rs6088459; rs11475580; rs843900; rs6120595; rs11428878; rs36043935; rs35505406; rs6120598; rs6059751; rs6088458; rs35077167; rs2297750; rs11482163; rs8116219; rs34161456; rs6120601; rs6120594; rs6120596; rs6059758; rs6087569; rs7352962; rs34586407; rs2181683; rs13036969; rs34610457; rs13036959; rs819170; rs11467322; rs6120593; rs6088460; rs11473946; rs11458444; rs17091733; rs35234313; rs1205349; rs1205350; rs6059762; rs6120592; rs6120602; rs8118727; rs819142; rs819144; rs819145; rs819176; rs819177

# Metabolic_Enzyme_3_General_References:
2596825; 11780052; 9586999

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5235

# Metabolic_Enzyme_4_Name:
Deoxycytidine kinase

# Metabolic_Enzyme_4_Synonyms:
dCK

# Metabolic_Enzyme_4_Gene_Name:
DCK

# Metabolic_Enzyme_4_Protein_Sequence:
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL

# Metabolic_Enzyme_4_Number_of_Residues:
260

# Metabolic_Enzyme_4_Molecular_Weight:
30519

# Metabolic_Enzyme_4_Theoretical_pI:
4.88

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  phosphotransferase activity, alcohol group as acceptor
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents

# Metabolic_Enzyme_4_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism

# Metabolic_Enzyme_4_Reaction:
NTP + deoxycytidine = NDP + dCMP

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF01712:dNK

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.7.1.74

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181510

# Metabolic_Enzyme_4_SwissProt_ID:
DCK_HUMAN (P27707)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
DCK

# Metabolic_Enzyme_4_Geneatlas_id:
DCK

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2704

# Metabolic_Enzyme_4_PDB_ID:
1P62

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Nucleus

# Metabolic_Enzyme_4_Gene_Sequence:
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M60527

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_4_Locus:
4q13.3-q21.1

# Metabolic_Enzyme_4_SNPs:
rs4643786; rs16845677; rs1385986; rs936868; rs936869; rs1486271; rs6446999; rs4694362; rs6446988; rs10518080; rs10805074; rs7684954; rs12648166; rs4235090; rs2010401; rs7669445; rs4490428; rs7439745; rs1552381; rs16845668; rs11935198; rs4308342; rs3775289; rs7672935; rs6819369; rs12513206; rs1580469; rs7699819; rs2171195; rs7684573; rs7697366; rs13106279; rs17686997; rs11728260; rs7691350; rs7690840; rs7659473; rs9993633; rs6841923; rs9997995; rs6446989; rs11731434; rs12513202; rs6446998; rs2035576; rs2129173; rs12501375; rs11737567; rs7672339; rs16845626; rs7659998; rs1385987; rs7693891; rs7672954; rs4694360; rs4525938; rs1906021; rs11544786; rs34662212; rs5859247; rs13124044; rs13124045; rs3065775; rs35686785; rs1803484; rs13124290; rs5859246; rs28734949; rs10019874; rs4021444; rs34857131; rs34482223; rs36018698; rs11394166; rs11935525; rs35461637; rs28867977; rs12503595; rs7656043; rs35177789; rs34193080; rs13117017; rs34109101; rs35278579; rs35147498; rs11460671; rs7699712; rs28404918; rs11337561; rs34139336; rs4694363; rs3833976; rs34969740; rs34676003; rs35858453; rs35754685; rs35688113; rs36078513; rs28545112; rs9997790; rs4597793; rs35755135; rs34078875; rs4377559; rs7698012; rs2363439; rs12511143; rs11728201; rs35880082; rs11315015; rs35477149; rs28715337; rs11429170; rs7689110; rs34763060; rs2171194; rs35003502; rs34851032; rs11322673; rs7439562; rs4694361; rs35261981; rs34205711; rs2306744; rs7689093; rs28671303; rs28687395; rs12642438; rs1385985; rs3733399; rs6446977; rs6836323; rs7656269

# Metabolic_Enzyme_4_General_References:
1996353; 2013338; 9342341

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5232

# Metabolic_Enzyme_5_Name:
Cytosolic 5'-nucleotidase 1B

# Metabolic_Enzyme_5_Synonyms:
Cytosolic 5'-nucleotidase IB; cN1B; cN-IB; Autoimmune infertility-related protein

# Metabolic_Enzyme_5_Gene_Name:
NT5C1B

# Metabolic_Enzyme_5_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
BMSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGH
SSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRS
QWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQP
PASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTS
PTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRP
WPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKAL
QYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYL
KAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEH
FTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTAR
SAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSI
AAYGFNKKFSS

# Metabolic_Enzyme_5_Number_of_Residues:
610

# Metabolic_Enzyme_5_Molecular_Weight:
68804

# Metabolic_Enzyme_5_Theoretical_pI:
9.03

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels

# Metabolic_Enzyme_5_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_5_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_5_Signals:
None

# Metabolic_Enzyme_5_Transmembrane_Regions:
None

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
13774961

# Metabolic_Enzyme_5_SwissProt_ID:
5NT1B_HUMAN (Q96P26)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
NT5C1B

# Metabolic_Enzyme_5_Geneatlas_id:
NT5C1B

# Metabolic_Enzyme_5_hgnc_id:
HGNC:17818

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_5_Gene_Sequence:
>1699 bp
GGGCAAAAATGTGGATAACAACAAAAGAATTTCAACAGGTAAAAAAATGAGTCAAACATC
TCTCAAACAGAAAAAGAATGAGCCCGGAATGAGGTCCTCAAAAGAGAGTCTAGAAGCAGA
AAAAAGAAAGGAATCTGACAAAACAGGAGTTCGTCTGAGCAATCAGGGATCACAAGAATC
ATCACTGCGGAAGACAGACTCTCGAGGGTACCTTGTGCGCAGTCAATGGTCTAGAATATC
CCGGAGCCCATCCACCAAGGCTCCATCCATAGATGAGCCTAGAAGCAGGAACACCAGTGC
TAAGCTCCCCAGCAGCTCCACGAGCTCCCGGACTCCATCCACCTCCCCAAGCCTGCATGA
CTCCTCACCGCCGCCGCTGTCCGGGCAGCCCTCGCTCCAGCCACCCGCGTCGCCCCAGCT
GCCCCGGTCGCTGGACTCGCGGCCTCCCACGCCCCCAGAGCCCGATCCTGGCTCCCGGCG
CAGCACCAAAATGCAAGAAAATCCGGAGGCCTGGGCCCAAGGCATCGTGCGGGAAATCCG
CCAGACCCGGGACTCGCAGCCGCTGGAATATTCGCGCACGTCCCCCACCGAGTGGAAGTC
CTCCAGCCAGCGCAGGGGGATCTACCCCGCCTCCACCCAGCTGGACCGCAACTCTCTGTC
CGAGCAGCAGCAGCAGCAGCGGGAGGACGAAGACGACTACGAAGCTGCCTACTGGGCATC
CATGAAGTCGTTCTACGAAAAGAACCCGAGCTGCTGGCGCCCCTGGCCGCCCAAACCCAA
GAACGCCATCACCATTGCTCTCTCATCCTGCGCGCTCTTCAACATGGTGGACGGCAGGAA
AATCTACGAGCAAGAGGGTCTGGAAAAGTACATGGAGTATCAGCTCACCAATGAGAACGT
CATCCTGACCCCGGGCCCGGCGTTCCGTTTCGTCAAGGCACTACAGTATGTCAATGCTAG
ACTCCGTGATCTATATCCTGATGAACAGGACTTATTTGATATTGTACTGATGACTAATAA
CCATGCCCAAGTGGGAGTGCGGCTTATAAACAGCGTCAATCACTACGGCTTACTGATTGA
CCGCTTCTGTCTGACCGGGGGAAAAGACCCCATTGGCTATTTGAAGGCATATCTTACCAA
CTTGTATATTGCTGCAGATTCTGAAAAAGTGCAAGAGGCAATACAAGAAGGTATTGCCTC
TGCGACAATGTTTGATGGAGCCAAAGACATGGCTTACTGTGACACTCAGCTCCGTGTAGC
CTTTGATGGGGATGCTGTCCTCTTCTCTGATGAGTCTGAACATTTTACCAAGGAGCATGG
GCTGGACAAATTCTTCCAGTATGATACATTATGTGAAAGTAAGCCTCTTGCTCAGGGTCC
CCTAAAAGGCTTTCTGGAAGATTTAGGCAGACTGCAAAAGAAGTTCTATGCCAAAAATGA
ACGGTTACTTTGTCCTATCAGGACCTACCTGGTTACAGCTAGGAGTGCAGCCAGTTCAGG
CGCCCGTGTGCTGAAAACCTTCCGACGCTGGGGTCTAGAGATAGACGAAGCTCTTTTCCT
TGCTGGAGCCCCCAAAAGTCCCATCTTGGTGAAGATCCGGCCCCACATCTTCTTTGATGA
CCACATGTTCCACATTGAAGGGGCACAGAGGTTAGGTTCCATCGCAGCTTATGGCTTTAA
TAAAAAATTCAGTAGTTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
AF356185

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p24.2

# Metabolic_Enzyme_5_SNPs:
rs3902946; rs16985301; rs16985306; rs3747660; rs2346137; rs6720633; rs7594728; rs6531109; rs6710367; rs7557821; rs4832608; rs11893074; rs16985296; rs7561652; rs2317857; rs16985292; rs16985290; rs6741218; rs11096544; rs35590292; rs10183289; rs17752103; rs11885013; rs17701334; rs16985293; rs11903725; rs7604190; rs4832609; rs7592099; rs16985311; rs16985310; rs3810839; rs17852342; rs34254789; rs7594519; rs34129467; rs7605480; rs35165251; rs7603601; rs34836771; rs34186303; rs35711606; rs35729409; rs34953851; rs11291136; rs28474708; rs3046807; rs34660980; rs35519366; rs3046840; rs35419885; rs7557722; rs4300829; rs7592233; rs13020403; rs36121694; rs34127788; rs11889898; rs13403096; rs13411442; rs1373776; rs16985281; rs16985284; rs17751951; rs2346135; rs2346136; rs34722188; rs35805648; rs3810838; rs3910894

# Metabolic_Enzyme_5_General_References:
11690631

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5935

# Metabolic_Enzyme_6_Name:
Putative adenosylhomocysteinase 2

# Metabolic_Enzyme_6_Synonyms:
S-adenosyl-L- homocysteine hydrolase 2; AdoHcyase 2; S-adenosylhomocysteine hydrolase-like 1; DC-expressed AHCY-like molecule

# Metabolic_Enzyme_6_Gene_Name:
AHCYL1

# Metabolic_Enzyme_6_Protein_Sequence:
>Putative adenosylhomocysteinase 2
MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQFADDMQEFTKFPTKTGR
RSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRREI
EIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIY
STQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKK
YPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKL
NEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVR
SQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPSFDAHLTELTDDQAKYLGLNKNGPFKPNYYRY

# Metabolic_Enzyme_6_Number_of_Residues:
530

# Metabolic_Enzyme_6_Molecular_Weight:
58952

# Metabolic_Enzyme_6_Theoretical_pI:
6.87

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_6_Pathway:
map00271  Methionine metabolism;
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_6_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF05221:AdoHcyase;
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_6_GenBank_ID_Protein:
16588687

# Metabolic_Enzyme_6_SwissProt_ID:
SAHH2_HUMAN (O43865)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
AHCYL1

# Metabolic_Enzyme_6_Geneatlas_id:
AHCYL1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:344

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Endoplasmic reticulum

# Metabolic_Enzyme_6_Gene_Sequence:
>1593 bp
ATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAG
GAGATCGAGGACGCCGAGAAGTACTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAG
CAAATCCAGTTTGCTGATGACATGCAGGAGTTCACCAAATTCCCCACCAAAACTGGCCGA
AGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCC
TACACAGATAGCTCTGATGATGAGGTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAG
GGCAGCAGCAATTTCTGTGTGAAGAACATCAAGCAGGCAGAATTTGGACGCCGGGAGATT
GAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAG
AAGCCCTTGGCTGGTGCTAAAATAGTGGGCTGTACACACATCACAGCCCAGACAGCGGTG
TTGATTGAGACACTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCTGCTTGTAACATCTAC
TCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGG
AAGGGCGAGTCAGAAGATGACTTCTGGTGGTGTATTGACCGCTGTGTGAACATGGATGGG
TGGCAGGCCAACATGATCCTGGATGATGGGGGAGACTTAACCCACTGGGTTTATAAGAAG
TATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCAC
AGGCTGTATCAGCTCTCCAAAGCTGGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGAT
TCTGTTACCAAACAGAAGTTTGATAACTTGTACTGCTGCCGAGAATCCATTTTGGATGGC
CTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGT
GAGGTAGGCAAGGGCTGCTGTGCTGCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACC
GAAATCGACCCCATCTGTGCTCTGCAGGCCTGCATGGATGGGTTCAGGGTGGTAAAGCTA
AATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTG
ACACGGGAGCACTTGGATCGCATGAAAAACAGTTGTATCGTATGCAATATGGGCCACTCC
AACACAGAAATCGATGTGACCAGCCTCCGCACTCCGGAGCTGACGTGGGAGCGAGTACGT
TCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGT
CGTCTACTCAATTTGAGCTGCTCCACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACA
ACACAGGCTTTGGCACTGATAGAACTCTATAATGCACCCGAGGGGCGATACAAGCAGGAT
GTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTT
GATGCCCACCTTACAGAGCTGACAGATGACCAAGCAAAATATCTGGGACTCAACAAAAAT
GGGCCATTCAAACCTAATTATTACAGATACTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AF315687

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_6_Locus:
1p13.2

# Metabolic_Enzyme_6_SNPs:
rs17551493; rs186724; rs3768480; rs7548583; rs720917; rs9429768; rs7538488; rs7514825; rs7553933; rs12077057; rs12075114; rs17025292; rs7550200; rs11102047; rs12566417; rs17025313; rs10857808; rs2298116; rs11588387; rs17668350; rs3754444; rs12084905; rs12090731; rs12077217; rs17025290; rs17025317; rs333074; rs167985; rs17025334; rs12089207; rs12093312; rs333082; rs6676611; rs17025345; rs12073761; rs12091710; rs17025328; rs7541329; rs3768478; rs333079; rs11102045; rs11544575; rs1418320; rs11544576; rs34932516; rs11424431; rs403648; rs404279; rs1804956; rs333078; rs34749267; rs193084; rs5776998; rs41280338; rs12076435; rs35533865; rs17025294; rs17611282; rs35263120; rs656878; rs11384766; rs6669183; rs17668509; rs34732614; rs417098; rs397017; rs34280839; rs34284174; rs34375964; rs377798; rs657325; rs34362438; rs12088989; rs396275; rs7517430; rs17611428; rs34585613; rs12408603; rs5776999; rs431097; rs35838523; rs179644; rs35658860; rs404275; rs12075746; rs35979464; rs34041834; rs387904; rs645979; rs34446452; rs443761; rs41280336; rs35423066; rs11428908; rs10159344; rs11349395; rs17025298; rs445885; rs443880; rs656499; rs36125467; rs333081; rs5777000; rs34394435; rs34617914; rs12044411; rs10715355; rs11102046; rs3737210; rs2173135; rs3806457; rs442976; rs1062657; rs34267468; rs11102043; rs11102048; rs12062571; rs12066280; rs12987; rs17025347; rs333075; rs35907078; rs394645; rs444477; rs450959; rs4838940; rs4839195; rs636380; rs7516357; rs7521290

# Metabolic_Enzyme_6_General_References:
11904675

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5805

# Metabolic_Enzyme_7_Name:
Purine nucleoside phosphorylase

# Metabolic_Enzyme_7_Synonyms:
Inosine phosphorylase; PNP

# Metabolic_Enzyme_7_Gene_Name:
NP

# Metabolic_Enzyme_7_Protein_Sequence:
>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

# Metabolic_Enzyme_7_Number_of_Residues:
289

# Metabolic_Enzyme_7_Molecular_Weight:
32118

# Metabolic_Enzyme_7_Theoretical_pI:
6.95

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  purine-nucleoside phosphorylase activity
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring pentosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_7_Reaction:
purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00896:Mtap_PNP

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.2.1

# Metabolic_Enzyme_7_GenBank_ID_Protein:
35565

# Metabolic_Enzyme_7_SwissProt_ID:
PNPH_HUMAN (P00491)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
NP

# Metabolic_Enzyme_7_Geneatlas_id:
NP

# Metabolic_Enzyme_7_hgnc_id:
HGNC:7892

# Metabolic_Enzyme_7_PDB_ID:
1RT9

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Not Available

# Metabolic_Enzyme_7_Gene_Sequence:
>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

# Metabolic_Enzyme_7_GenBank_ID_Gene:
X00737

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_7_Locus:
14q13.1

# Metabolic_Enzyme_7_SNPs:
rs1049564; rs1130650; rs1049562; rs7785; rs1617940; rs1760940; rs1713420; rs1760935; rs1713422; rs1713421; rs3790064; rs3790065; rs1713429; rs17882804; rs17880405; rs1756369; rs12147688; rs8008133; rs17881431; rs17881345; rs7154909; rs17883821; rs17885781; rs1760934; rs17879107; rs17880844; rs17879913; rs17881184; rs17885714; rs17880480; rs17883253; rs17878900; rs1713426; rs17881356; rs1713427; rs1760933; rs3790062; rs17883795; rs17112168; rs17880290; rs12147906; rs17881554; rs17881206; rs1049700; rs17882836; rs12101049; rs17884106; rs12147035; rs34480769; rs3838361; rs3842517; rs1760939; rs17885917; rs17886095; rs1760938; rs17883294; rs17883604; rs8019880; rs17881280; rs35549071; rs35139440; rs17880503; rs7151666; rs10498268; rs1079375; rs1079376; rs11846743; rs11850059; rs11850069; rs12587218; rs12886203; rs12888804; rs12891271; rs13379232; rs13379234; rs1629478; rs17112384; rs17112385; rs1713459; rs1713460; rs1713461; rs1713462; rs17242655; rs17242662; rs17242669; rs1756365; rs1760930; rs1760931; rs1760941; rs1760942; rs2077153; rs2481768; rs35175606; rs35567022; rs7156659; rs755777

# Metabolic_Enzyme_7_General_References:
6087295; 3029074; 12928150; 2104852; 1384322; 8931706

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5229

# Metabolic_Enzyme_8_Name:
5'-nucleotidase precursor

# Metabolic_Enzyme_8_Synonyms:
Ecto-5'-nucleotidase; 5'-NT; CD73 antigen

# Metabolic_Enzyme_8_Gene_Name:
NT5E

# Metabolic_Enzyme_8_Protein_Sequence:
>5'nucleotidase precursor
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ

# Metabolic_Enzyme_8_Number_of_Residues:
574

# Metabolic_Enzyme_8_Molecular_Weight:
63368

# Metabolic_Enzyme_8_Theoretical_pI:
7.04

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  hydrolase activity, acting on ester bonds
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  nucleotide catabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides

# Metabolic_Enzyme_8_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_8_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF02872:5_nucleotid_C;
PF00149:Metallophos

# Metabolic_Enzyme_8_Signals:
1-26

# Metabolic_Enzyme_8_Transmembrane_Regions:
556-573

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_8_GenBank_ID_Protein:
23897

# Metabolic_Enzyme_8_SwissProt_ID:
5NTD_HUMAN (P21589)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
NT5E

# Metabolic_Enzyme_8_Geneatlas_id:
NT5E

# Metabolic_Enzyme_8_hgnc_id:
HGNC:8021

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_8_Gene_Sequence:
>1725 bp
ATGTGTCCCCGAGCCGCGCGGGCGCCCGCGACGCTACTCCTCGCCCTGGGCGCGGTGCTG
TGGCCTGCGGCTGGCGCCTGGGAGCTTACGATTTTGCACACCAACGACGTGCACAGCCGG
CTGGAGCAGACCAGCGAGGACTCCAGCAAGTGCGTCAACGCCAGCCGCTGCATGGGTGGC
GTGGCTCGGCTCTTCACCAAGGTTCAGCAGATCCGCCGCGCCGAACCCAACGTGCTGCTG
CTGGACGCCGGCGACCAGTACCAGGGCACTATCTGGTTCACCGTGTACAAGGGCGCCGAG
GTGGCGCACTTCATGAACGCCCTGCGCTACGATGCCATGGCACTGGGAAATCATGAATTT
GATAATGGTGTGGAAGGACTGATCGAGCCACTCCTCAAAGAGGCCAAATTTCCAATTCTG
AGTGCAAACATTAAAGCAAAGGGGCCACTAGCATCTCAAATATCAGGACTTTATTTGCCA
TATAAAGTTCTTCCTGTTGGTGATGAAGTTGTGGGAATCGTTGGATACACTTCCAAAGAA
ACCCCTTTTCTCTCAAATCCAGGGACAAATTTAGTGTTTGAAGATGAAATCACTGCATTA
CAACCTGAAGTAGATAAGTTAAAAACTCTAAATGTGAACAAAATTATTGCACTGGGACAT
TCGGGTTTTGAAATGGATAAACTCATCGCTCAGAAAGTGAGGGGTGTGGACGTCGTGGTG
GGAGGACACTCCAACACATTTCTTTACACAGGCAATCCACCTTCCAAAGAGGTGCCTGCT
GGGAAGTACCCATTCATAGTCACTTCTGATGATGGGCGGAAGGTTCCTGTAGTCCAGGCC
TATGCTTTTGGCAAATACCTAGGCTATCTGAAGATCGAGTTTGATGAAAGAGGAAACGTC
ATCTCTTCCCATGGAAATCCCATTCTTCTAAACAGCAGCATTCCTGAAGATCCAAGCATA
AAAGCAGACATTAACAAATGGAGGATAAAATTGGATAATTATTCTACCCAGGAATTAGGG
AAAACAATTGTCTATCTGGATGGCTCCTCTCAATCATGCCGCTTTAGAGAATGCAACATG
GGCAACCTGATTTGTGATGCAATGATTAACAACAACCTGAGACACACGGATGAAATGTTC
TGGAACCACGTATCCATGTGCATTTTAAATGGAGGTGGTATCCGGTCGCCCATTGATGAA
CGCAACAATGGCACAATTACCTGGGAGAACCTGGCTGCTGTATTGCCCTTTGGAGGCACA
TTTGACCTAGTCCAGTTAAAAGGTTCCACCCTGAAGAAGGCCTTTGAGCATAGCGTGCAC
CGCTACGGCCAGTCCACTGGAGAGTTCCTGCAGGTGGGCGGAATCCATGTGGTGTATGAT
CTTTCCCGAAAACCTGGAGACAGAGTAGTCAAATTAGATGTTCTTTGCACCAAGTGTCGA
GTGCCCAGTTATGACCCTCTCAAAATGGACGAGGTATATAAGGTGATCCTCCCAAACTTC
CTGGCCAATGGTGGAGATGGGTTCCAGATGATAAAAGATGAATTATTAAGACATGACTCT
GGTGACCAAGATATCAACGTGGTTTCTACATATATCTCCAAAATGAAAGTAATTTATCCA
GCAGTTGAAGGTCGGATCAAGTTTTCCACAGGAAGTCACTGCCATGGAAGCTTTTCTTTA
ATATTTCTTTCACTTTGGGCAGTGATCTTTGTTTTATACCAATAG

# Metabolic_Enzyme_8_GenBank_ID_Gene:
X55740

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_8_Locus:
6q14-q21

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
2129526; 8566797; 2173922; 9651114

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5234

# Metabolic_Enzyme_9_Name:
5'(3')-deoxyribonucleotidase, cytosolic type

# Metabolic_Enzyme_9_Synonyms:
Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1

# Metabolic_Enzyme_9_Gene_Name:
NT5C

# Metabolic_Enzyme_9_Protein_Sequence:
>5'3'deoxyribonucleotidase, cytosolic type
MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHL
GPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRL
LSWSDNWREILDSKRGAAQRE

# Metabolic_Enzyme_9_Number_of_Residues:
201

# Metabolic_Enzyme_9_Molecular_Weight:
23383

# Metabolic_Enzyme_9_Theoretical_pI:
6.63

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_9_Signals:
None

# Metabolic_Enzyme_9_Transmembrane_Regions:
None

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_9_GenBank_ID_Protein:
7524492

# Metabolic_Enzyme_9_SwissProt_ID:
NT5C_HUMAN (Q8TCD5)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
NT5C

# Metabolic_Enzyme_9_Geneatlas_id:
NT5C

# Metabolic_Enzyme_9_hgnc_id:
HGNC:17144

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_9_Gene_Sequence:
>606 bp
ATGGCGCGGAGCGTGCGCGTGCTGGTGGACATGGACGGCGTCCTGGCCGACTTCGAGGCC
GGCCTCCTGCGGGGCTTCCGCCGCCGCTTCCCTGAGGAGCCGCACGTGCCGCTGGAGCAA
CGCCGCGGCTTCCTGGCCCGCGAGCAGTACCGCGCCCTGCGGCCCGACCTGGCGGATAAA
GTGGCCAGTGTGTACGAAGCCCCGGGCTTTTTCCTGGACCTGGAGCCCATCCCGGGAGCC
TTGGACGCTGTGCGGGAGATGAACGACCTACCGGACACGCAGGTCTTCATCTGCACCAGC
CCCCTGCTGAAGTACCACCACTGTGTGGGTGAGAAGTACCGCTGGGTGGAGCAGCACCTG
GGGCCCCAGTTCGTAGAACGAATTATCCTGACAAGGGACAAGACGGTGGTCTTGGGGGAC
CTGCTCATTGATGACAAGGACACAGTTCGAGGCCAGGAGGAGACCCCAAGCTGGGAGCAC
ATCTTGTTCACCTGCTGCCACAATCGGCACCTGGTCCTGCCCCCGACAAGGAGACGGCTG
CTCTCCTGGAGTGACAACTGGAGGGAGATCTTAGATAGCAAGCGCGGAGCTGCGCAGCGG
GAATGA

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF154829

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_9_Locus:
17q25.1

# Metabolic_Enzyme_9_SNPs:
rs4788867; rs11868451; rs3736076; rs3736075; rs12453556; rs4789144; rs11652099; rs4789143; rs11541956; rs12945569; rs3188816; rs12946860; rs1048779; rs12943507; rs34746270; rs11541955; rs12945517; rs9910084; rs34454120; rs7406461; rs4788868; rs11868212; rs1551966; rs2291027; rs2291028; rs34338273; rs3752801; rs4412997; rs4789145; rs750843; rs750844; rs899316; rs899317

# Metabolic_Enzyme_9_General_References:
10681516; 12234672

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5912

# Metabolic_Enzyme_10_Name:
Adenosine kinase

# Metabolic_Enzyme_10_Synonyms:
AK; Adenosine 5'-phosphotransferase

# Metabolic_Enzyme_10_Gene_Name:
ADK

# Metabolic_Enzyme_10_Protein_Sequence:
>Adenosine kinase
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

# Metabolic_Enzyme_10_Number_of_Residues:
362

# Metabolic_Enzyme_10_Molecular_Weight:
40546

# Metabolic_Enzyme_10_Theoretical_pI:
6.67

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring phosphorus-containing groups
Function:  kinase activity
Function:  nucleobase, nucleoside, nucleotide kinase activity
Function:  nucleoside kinase activity
Function:  adenosine kinase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  purine salvage
Process:  purine ribonucleoside salvage
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides

# Metabolic_Enzyme_10_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + adenosine = ADP + AMP

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00294:PfkB

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.7.1.20

# Metabolic_Enzyme_10_GenBank_ID_Protein:
1224125

# Metabolic_Enzyme_10_SwissProt_ID:
ADK_HUMAN (P55263)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
ADK

# Metabolic_Enzyme_10_Geneatlas_id:
ADK

# Metabolic_Enzyme_10_hgnc_id:
HGNC:257

# Metabolic_Enzyme_10_PDB_ID:
1BX4

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Not Available

# Metabolic_Enzyme_10_Gene_Sequence:
>1038 bp
ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCT
GCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAACCAAATGACCAAATCTTG
GCTGAAGACAAACACAAGGAACTGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATAT
CATGCTGGTGGCTCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCA
CACAAAGCAGCAACATTTTTTGGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAG
AGAAAAGCTGCTGAAGCCCATGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACA
GGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCT
GCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTGGTAGAA
AAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTCACGTTTCCCCAGAGTCAGTATTA
AAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCG
TTTATTAGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTT
TTTGGAAATGAGACAGAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGAC
ATTAAAGAGATAGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGA
ATCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTGAAGTCACT
GCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATACCAATGGAGCTGGAGAT
GCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACTGAATGTATC
CGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG
AAGCCAGACTTCCACTGA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
U50196

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_10_Locus:
10q22|10q11-q24

# Metabolic_Enzyme_10_SNPs:
rs16931480; rs1189553; rs10824095; rs2169682; rs2894236; rs1904060; rs1904067; rs1904066; rs1871088; rs1908335; rs719624; rs1871085; rs1871087; rs2894234; rs1904064; rs871267; rs10824166; rs7350403; rs10824172; rs7090732; rs10824087; rs7894466; rs2395096; rs1898057; rs6480741; rs10740440; rs6480745; rs7098277; rs10509348; rs7079515; rs7909197; rs7899674; rs6480721; rs11597563; rs10740439; rs4451661; rs1898055; rs7079633; rs2126768; rs4390292; rs10824163; rs6480734; rs7083427; rs2169683; rs2395092; rs7072264; rs7092245; rs7922519; rs4746191; rs10824183; rs10762587; rs7100452; rs7094239; rs4564273; rs1898056; rs7096553; rs4237279; rs7087566; rs11000920; rs10762595; rs7068789; rs7100550; rs6480733; rs10762582; rs4323810; rs7098200; rs2306161; rs10824170; rs7084786; rs10824165; rs10762621; rs7923414; rs10824182; rs7916445; rs6480742; rs7082003; rs961321; rs10762624; rs10824094; rs7093532; rs7908160; rs2395095; rs6480749; rs4320897; rs10762606; rs9665468; rs10733903; rs10762601; rs11001022; rs10824133; rs10824119; rs4077282; rs10509350; rs10762640; rs4746181; rs10824195; rs7918318; rs4459229; rs6480739; rs4261231; rs10762605; rs7082872; rs3862535; rs6480727; rs7918927; rs2395087; rs10824120; rs10824186; rs7078351; rs7087368; rs7914902; rs4746214; rs1904061; rs11001105; rs10762615; rs7083534; rs10824177; rs7085940; rs10740437; rs4746182; rs10740436; rs11001043; rs2126760; rs11818050; rs6480726; rs10762612; rs7895133; rs7075643; rs7095850; rs10740443; rs4746221; rs10824185; rs4353215; rs2395097; rs2126763; rs7924176; rs7910153; rs7919277; rs7072220; rs10762636; rs10762622; rs11000931; rs4745739; rs3781255; rs10762588; rs10824138; rs10824218; rs10762638; rs2126765; rs6480731; rs4745749; rs4338470; rs7074939; rs7079709; rs4746207; rs7921187; rs11819334; rs11000960; rs11001089; rs4561146; rs11815260; rs10824193; rs10762629; rs10824135; rs7917790; rs10824105; rs11597376; rs11817779; rs7897750; rs11593868; rs4746216; rs7919166; rs11001052; rs12573619; rs10762620; rs10824197; rs7071324; rs10762596; rs11816566; rs7912162; rs7072504; rs11813905; rs10824161; rs2126767; rs10762603; rs10733895; rs7097320; rs11813953; rs7072012; rs10824122; rs7909915; rs12573590; rs4746177; rs10762639; rs726120; rs10824188; rs7913606; rs4745743; rs10740423; rs11001020; rs7075393; rs4746212; rs7923626; rs4746190; rs1556822; rs946186; rs7899920; rs10762630; rs10824134; rs12784355; rs16931294; rs2117791; rs2078036; rs12571088; rs10762607; rs10824192; rs10824137; rs11001028; rs7477710; rs10824098; rs946185; rs11814981; rs11001046; rs7916143; rs6480732; rs4745750; rs7914995; rs10509347; rs7069460; rs10740441; rs7075956; rs10762591; rs4376843; rs4281434; rs10824208; rs7901031; rs11000964; rs11818752; rs10824101; rs7099494; rs1904062; rs10762635; rs11813032; rs10824106; rs10824160; rs2126766; rs11001002; rs10762611; rs11000925; rs6480724; rs10762599; rs16931395; rs11000911; rs7917666; rs7896617; rs11816554; rs11000939; rs958620; rs12416316; rs10762641; rs10824130; rs7073742; rs12355686; rs11813815; rs2164367; rs11001109; rs9665469; rs7098337; rs10824124; rs10762619; rs10824092; rs1904065; rs12772532; rs10824174; rs7901055; rs4639878; rs1556821; rs11814426; rs6480723; rs12360119; rs10824152; rs11813920; rs10824164; rs7073340; rs10824143; rs10824103; rs4489684; rs10824210; rs12570185; rs16931536; rs1993861; rs10824151; rs12571589; rs16931460; rs11001005; rs10824144; rs7923592; rs11598232; rs10762626; rs10824128; rs10762581; rs7084139; rs1556820; rs1904058; rs10509351; rs7100084; rs11000924; rs11001018; rs12569971; rs7895587; rs2395078; rs12416497; rs10762631; rs11001053; rs11814705; rs11814063; rs10762593; rs9971034; rs16931332; rs11815536; rs11001111; rs11001007; rs4746196; rs7920097; rs16931462; rs7097778; rs12573807; rs11001099; rs11001092; rs11813221; rs7073139; rs11001034; rs12572721; rs10824102; rs1904063; rs11001004; rs10824108; rs10509349; rs10824194; rs10733904; rs10740432; rs6480740; rs3862536; rs12573198; rs7896660; rs11000922; rs10762600; rs7089391; rs12412109; rs10824096; rs10824153; rs7476181; rs11001047; rs6480729; rs10740420; rs4746192; rs7896152; rs7906603; rs7894143; rs10824221; rs2894235; rs10762608; rs7086014; rs10824129; rs11001096; rs7915999; rs7902519; rs4746188; rs11812862; rs2131955; rs2126769; rs6480722; rs11598022; rs10824146; rs10824090; rs12415957; rs11812826; rs12412071; rs4745751; rs7084204; rs7087290; rs13376718; rs10762577; rs7914783; rs10824154; rs12243059; rs7088329; rs11001029; rs11000921; rs10762586; rs1908333; rs11000928; rs7905039; rs35074621; rs12357589; rs11000948; rs10740431; rs11000997; rs11001006; rs7895292; rs11812696; rs12573068; rs11000914; rs7089625; rs7081350; rs7074449; rs11001045; rs4501938; rs7922635; rs7898073; rs7903786; rs10762637; rs12220238; rs12251845; rs12217890; rs12259556; rs6480748; rs11001115; rs16931364; rs11001059; rs10762583; rs11000899; rs11000966; rs10762613; rs4746194; rs4341485; rs6480744; rs9664463; rs12261738; rs12360399; rs12572648; rs7919517; rs11001102; rs10128407; rs10824097; rs11001085; rs12360087; rs4746180; rs6480728; rs12573347; rs11001014; rs11594742; rs11000977; rs10824107; rs10824198; rs11599616; rs10824147; rs16931492; rs10824212; rs4615968; rs12268556; rs11000996; rs4745738; rs12359456; rs16931504; rs11001003; rs956118; rs12415743; rs12261586; rs7091715; rs12356618; rs11001114; rs1871086; rs12241337; rs12569368; rs11001103; rs10740421; rs6480730; rs9299518; rs7900243; rs10824117; rs12254109; rs4746189; rs7897539; rs10762585; rs11000951; rs10824113; rs10824104; rs16931528; rs11817059; rs4745744; rs16931523; rs11597443; rs10824148; rs16931525; rs16931367; rs11000988; rs10762602; rs6480746; rs7905536; rs10762618; rs12256590; rs7069107; rs10824142; rs12098284; rs7091719; rs11819665; rs11000959; rs7091300; rs11819705; rs16931516; rs12252558; rs16931474; rs7919010; rs10824123; rs7913178; rs11000909; rs11000915; rs12243409; rs12572696; rs7920185; rs7897778; rs12569733; rs7067813; rs4746198; rs7096664; rs16931341; rs7094284; rs7903760; rs11000945; rs11001015; rs7088944; rs7897643; rs1908334; rs10824111; rs12415794; rs11001090; rs12217753; rs11591270; rs16931520; rs4745740; rs7088149; rs11000927; rs4746202; rs7076721; rs16931511; rs9651336; rs16931546; rs12779371; rs7902089; rs12569695; rs12253120; rs9664464; rs946184; rs10824116; rs10762614; rs12416580; rs4746209; rs11598266; rs4746210; rs7921832; rs16931468; rs11818734; rs10824169; rs11000992; rs7085860; rs11000936; rs11819396; rs4331029; rs10824136; rs10740442; rs1416101; rs10762594; rs11812834; rs12569856; rs12775658; rs10824171; rs7904939; rs10824140; rs7073432; rs16931449; rs12268312; rs10824110; rs11001112; rs11001078; rs7073227; rs10824099; rs12414029; rs4745747; rs7920006; rs4745745; rs12260506; rs12359289; rs12415761; rs11000990; rs11001087; rs4341483; rs11814484; rs11817882; rs11000901; rs11000980; rs11000946; rs12355188; rs7901569; rs10824112; rs10824100; rs16931465; rs10824149; rs2395091; rs10430473; rs11595136; rs11000999; rs10824109; rs10824168; rs1531; rs10430521; rs4745741; rs12242776; rs7895061; rs12773903; rs10762598; rs10824209; rs7905662; rs11815035; rs12354678; rs10824220; rs12098289; rs4746197; rs11000994; rs7099552; rs7069901; rs11000912; rs7071823; rs10824175; rs7083605; rs4746187; rs12569670; rs12356350; rs7918573; rs10824115; rs10824181; rs12570624; rs7092741; rs10824203; rs11819074; rs11001031; rs7910626; rs12415736; rs10762609; rs11001027; rs12268597; rs11001016; rs4746218; rs12570022; rs11000941; rs11000986; rs10824139; rs7086415; rs12354659; rs17747401; rs2126764; rs11599320; rs12414489; rs7080815; rs10824118; rs10824091; rs7901524; rs11812815; rs12572580; rs16931477; rs10762584; rs7904489; rs4745752; rs7906759; rs12572155; rs7084146; rs11516630; rs7901242; rs11001013; rs7074327; rs4746215; rs7898517; rs10824088; rs10824167; rs10824125; rs10824132; rs10824141; rs11599829; rs11000962; rs11594739; rs10824121; rs11813394; rs12357370; rs11000900; rs7904773; rs10824211; rs10762589; rs11000947; rs7091823; rs12252705; rs11000981; rs7087567; rs11001048; rs16931519; rs7918003; rs16931521; rs7085334; rs12265663; rs10762617; rs16931527; rs11001116; rs12411935; rs12779309; rs4746211; rs7898405; rs12242814; rs10762592; rs10762616; rs11001019; rs10430474; rs2395093; rs10824202; rs1538311; rs10824114; rs10740433; rs12573649; rs7907801; rs1529; rs11000934; rs10824150; rs10740438; rs16931538; rs11001001; rs7081573; rs11817959; rs11000987; rs7907267; rs6480743; rs7906779; rs11819130; rs16931490; rs10824190; rs2169684; rs11001008; rs11000954; rs11000916; rs7894697; rs16931472; rs1189552; rs2126762; rs1052039; rs28433006; rs12767624; rs10709030; rs7476928; rs10699958; rs35967107; rs4328165; rs12256125; rs35681751; rs6480750; rs34148029; rs35946213; rs34428151; rs36030657; rs34269690; rs3037403; rs28806480; rs34213308; rs35291653; rs12265290; rs10587775; rs11001010; rs10400100; rs5786147; rs35242280; rs34546969; rs35683991; rs10618104; rs34215048; rs35938247; rs768959; rs12769918; rs36029311; rs7909834; rs11000950; rs35036011; rs33912244; rs4746184; rs4369336; rs11000973; rs35746333; rs2027266; rs12264178; rs12768982; rs5786138; rs11427369; rs36100829; rs34310248; rs34469098; rs11470196; rs11000993; rs11310691; rs35270154; rs7392652; rs35240931; rs11001076; rs34868542; rs35677795; rs12253997; rs11001024; rs11361618; rs34483117; rs1016419; rs11001062; rs35389691; rs4746213; rs12770163; rs12242773; rs12250065; rs714446; rs7478561; rs11000983; rs35213595; rs35124446; rs12360425; rs11001041; rs7101087; rs12768640; rs34991446; rs11001107; rs34157587; rs34960972; rs11001063; rs6143984; rs11001033; rs10824216; rs7068038; rs11000963; rs12769277; rs12221297; rs34006036; rs35913987; rs35593805; rs11000958; rs35690083; rs12776428; rs12359909; rs35675013; rs34160937; rs17682987; rs11298231; rs28665887; rs34822835; rs10693309; rs12358321; rs11294383; rs35382240; rs11441752; rs11000932; rs3192342; rs10443948; rs34368934; rs16931389; rs4746219; rs7085007; rs16931551; rs12784339; rs34785655; rs35885564; rs34253447; rs34545592; rs35474264; rs35954951; rs12261116; rs1871083; rs4746220; rs12769928; rs35213605; rs34146097; rs11001025; rs1904059; rs35282438; rs34630297; rs35244559; rs36064398; rs12772349; rs35081895; rs10719538; rs12358053; rs12770150; rs10824219; rs4578321; rs11812645; rs11000944; rs11377985; rs9730888; rs11001039; rs35189522; rs11377715; rs10578956; rs12245560; rs11464387; rs11001088; rs1908336; rs2395089; rs11000918; rs7478196; rs11001093; rs35289591; rs35155141; rs10630238; rs11000935; rs11283273; rs11431842; rs11498031; rs12241229; rs12779690; rs35621346; rs35957820; rs11516631; rs35088225; rs28540400; rs35958238; rs3758511; rs11427347; rs35956325; rs11000905; rs12780859; rs34456914; rs12257326; rs11000910; rs2951091; rs11419041; rs35418682; rs35969519; rs34509827; rs34011472; rs11001073; rs13376894; rs16931407; rs11001066; rs3037448; rs34427535; rs12359976; rs11285474; rs28756681; rs34190731; rs11292901; rs34798510; rs12775686; rs7076019; rs12571515; rs35698592; rs10568623; rs7079178; rs35634749; rs35197598; rs11000998; rs34848917; rs7070345; rs35336446; rs35924345; rs34395307; rs35681211; rs34203173; rs7074078; rs11000949; rs12251148; rs11294980; rs34484828; rs7070707; rs5786139; rs35196181; rs7909032; rs34729493; rs34311007; rs35676834; rs34350496; rs35653353; rs35343842; rs35944635; rs34770422; rs35567434; rs11592151; rs34334128; rs4746208; rs12217863; rs12776780; rs10710680; rs34328974; rs11354070; rs35548449; rs35138612; rs11000937; rs5786136; rs34975658; rs11001051; rs5786148; rs12768637; rs12776762; rs11001032; rs35565783; rs35141788; rs5786145; rs34381749; rs34206298; rs16931588; rs11000972; rs34606636; rs35192408; rs11313699; rs11819453; rs12257167; rs35322063; rs34758567; rs11394734; rs4746193; rs34040400; rs12416047; rs7100239; rs35010757; rs11001050; rs35043540; rs35574014; rs35285241; rs12769920; rs11001077; rs35801937; rs9888065; rs12572719; rs12776511; rs11446202; rs11001023; rs4400738; rs34865824; rs3837336; rs12771556; rs35658711; rs11001042; rs9732237; rs34077396; rs12781732; rs12268885; rs16931430; rs34241739; rs11527234; rs11818880; rs12250504; rs12771964; rs4746185; rs11310513; rs7074915; rs35543329; rs7088493; rs34445084; rs12414124; rs10631417; rs35870828; rs35153697; rs12570068; rs2126761; rs11000976; rs12259418; rs35120068; rs34312133; rs4589228; rs34043389; rs34232307; rs11000965; rs34313197; rs12261108; rs12267421; rs35345171; rs12781539; rs1898054; rs34844657; rs12244479; rs11000933; rs12770253; rs1832436; rs35239000; rs4639879; rs35111858; rs11313781; rs12146408; rs7099493; rs36104559; rs12573253; rs12767938; rs34722640; rs35137924; rs35527525; rs35650817; rs34057132; rs34149159; rs11463660; rs11598404; rs2027265; rs41280418; rs34554027; rs12772421; rs11001068; rs11000961; rs10554301; rs11001113; rs10400099; rs35788249; rs11001074; rs11001049; rs35392498; rs11001079; rs11381604; rs34757853; rs11000984; rs10633386; rs28367539; rs35193175; rs5786149; rs36126508; rs11367583; rs34369353; rs12262949; rs35927711; rs949720; rs12769308; rs11001106; rs9733631; rs34985864; rs11527423; rs11289206; rs2894237; rs11320887; rs35035527; rs10596248; rs34829852; rs35566961; rs35148425; rs12259513; rs2395088; rs12777975; rs11001055; rs7078624; rs4746217; rs35385535; rs34440443; rs5786151; rs35822474; rs7478047; rs34684326; rs34778804; rs9731072; rs34447904; rs11458497; rs11361273; rs34029062; rs34301605; rs34969882; rs35062545; rs34668568; rs11596973; rs35067531; rs11000971; rs11000919; rs35038709; rs34848555; rs34943780; rs12775085; rs13376895; rs28550755; rs35630116; rs35480343; rs12358427; rs7476100; rs11001054; rs7916584; rs34117712; rs10646695; rs11001060; rs34025605; rs12782778; rs11000989; rs10550667; rs11001094; rs12254751; rs11001083; rs10592912; rs11001081; rs7914846; rs11001069; rs7083128; rs12771949; rs35844167; rs34807188; rs35351336; rs28798394; rs34628857; rs34464248; rs10653576; rs34498680; rs16931301; rs34644210; rs35318416; rs12357530; rs4506580; rs28886966; rs11527424; rs28711776; rs35836498; rs34575360; rs35138837; rs36106558; rs2894238; rs35333397; rs34945364; rs12261051; rs10546914; rs28705900; rs11000930; rs34022905; rs34369612; rs5786140; rs12415282; rs11001117; rs11451786; rs34788425; rs7476538; rs11000956; rs5786137; rs11000923; rs35465617; rs11001012; rs12355952; rs12267197; rs4303177; rs12254040; rs36070427; rs12770467; rs11000952; rs2027268; rs34323155; rs3037396; rs35856088; rs35278865; rs12357643; rs35046845; rs11434396; rs34777095; rs11597052; rs10667574; rs12763748; rs12414280; rs34427766; rs11498032; rs3037400; rs35287036; rs35285709; rs10710237; rs4746186; rs3037446; rs41405146; rs4746179; rs36119808; rs7072529; rs35194075; rs7094743; rs11300921; rs11000957; rs35630271; rs34844177; rs11597340; rs35918774; rs35774493; rs11599870; rs34794280; rs16931444; rs34535203; rs36041609; rs35654646; rs11357215; rs34600695; rs35167424; rs11000991; rs12764263; rs28620392; rs12765352; rs34417435; rs35499084; rs5786150; rs12771367; rs34006665; rs3957133; rs11000967; rs34878578; rs35302558; rs12255237; rs2395090; rs12098843; rs12220218; rs35091445; rs12251416; rs12764980; rs11598353; rs34605650; rs36016023; rs10693107; rs11596436; rs11000985; rs11492360; rs7100311; rs35008670; rs11001064; rs11000979; rs11001058; rs35705914; rs35798713; rs34320598; rs35102669; rs7090447; rs12261107; rs34385041; rs12267892; rs11593990; rs34053466; rs11312116; rs34287044; rs12767472; rs12359775; rs34820269; rs35056778; rs11000926; rs34396421; rs12355723; rs7083096; rs34992970; rs34064444; rs11000907; rs11001038; rs10578552; rs35152713; rs35733476; rs34480841; rs11001009; rs2395094; rs12775961; rs10558951; rs5786142; rs17744431; rs35872639; rs35658993; rs10535419; rs35203634; rs16931563; rs35781747; rs34577685; rs7082866; rs10527692; rs35945477; rs10565601; rs12248996; rs10657653; rs16931425; rs10612340; rs11000942; rs28673867; rs11001011; rs35803794; rs11000975; rs11380814; rs7093745; rs12782355; rs35927517; rs1140726; rs12262204; rs11000929; rs2027267; rs6480747; rs12247758; rs35796098; rs28457756; rs11000917; rs28599671; rs12767217; rs34601191; rs17746699; rs12098261; rs12255345; rs12250748; rs36073830; rs11297052; rs34377885; rs35708858; rs34454856; rs12241160; rs10669118; rs34336674; rs34920875; rs11001070; rs12415222; rs35421202; rs35759508; rs35249335; rs34947578; rs10400203; rs35521667; rs34161719; rs5786141; rs730660; rs11383205; rs34975150; rs2927517; rs7087005; rs11001021; rs3998213; rs12783210; rs35081179; rs10536957; rs34761801; rs11317030; rs11597174; rs35949478; rs7899397; rs12783738; rs17685047; rs11311986; rs35070470; rs28583797; rs35998695; rs11001095; rs12768800; rs34632561; rs7358249; rs34610545; rs719944; rs10559831; rs34130571; rs34419004; rs34492397; rs35960706; rs11000902; rs16931508; rs12356357; rs35369268; rs35568529; rs11000978; rs11368451; rs7909196; rs11596716; rs11591337; rs10612480; rs10710238; rs35423162; rs36067412; rs35503260; rs11001071; rs35720770; rs4746183; rs35744043; rs12250637; rs4448625; rs4746206; rs12772768; rs11377208; rs12781289; rs34033009; rs34705543; rs12770119; rs12261147; rs11510969; rs35092600; rs35989197; rs34809429; rs11001061; rs28588347; rs11356202; rs4745746; rs12221444; rs34137547; rs10534993; rs12765322; rs34589243; rs28891140; rs35036906; rs5786146; rs7101010; rs35057058; rs12763083; rs12241919; rs35010094; rs35210704; rs11001108; rs1131988; rs12776754; rs12764241; rs11285475; rs35913612; rs12773960; rs11000995; rs11279355; rs34842035; rs11592294; rs12219767; rs35370125; rs35785348; rs34133995; rs12243218; rs34631179; rs12763766; rs34123435; rs12251389; rs35116974; rs35655878; rs35281622; rs35717142; rs35955774; rs12249241; rs34740358; rs12261563; rs11492299; rs12767200; rs34775607; rs34490010; rs36042076; rs11447835; rs35273093; rs11402306; rs11814352; rs11388849; rs12241943; rs28422778; rs10689388; rs11000982; rs11597668; rs35085839; rs11278279; rs34137673; rs11001104; rs11000974; rs11001080; rs34027811; rs5786143; rs35689397; rs7898976; rs35973082; rs11001017; rs35190282; rs34346566; rs12775960; rs12769919; rs12267534; rs12251369; rs7071553; rs10698256; rs34893135; rs28612186; rs35236497; rs28842181; rs35388074; rs11000943; rs7081474; rs34535580; rs12269424; rs10682966; rs10670267; rs11000968; rs34357111; rs34359934; rs11001075; rs16931359; rs12356967; rs35233016; rs11001030; rs12255362; rs11372723; rs4638258; rs4341484; rs16931393; rs11001086; rs11000913; rs12243374; rs4745742; rs34770607; rs12778270; rs34660792; rs11000906; rs11001026; rs28473266; rs4746200; rs7089267; rs12764238; rs11001037; rs12359146; rs3837337; rs1051938; rs1051939; rs10824083; rs10824085; rs10824086; rs11000888; rs11000889; rs11000892; rs11000893; rs11000894; rs11000897; rs11817132; rs1189549; rs1189550; rs1189551; rs12256105; rs12358614; rs12572479; rs12778712; rs1338389; rs1766711; rs1766713; rs17676126; rs1774692; rs1871084; rs1874147; rs1908330; rs2788148; rs2894228; rs3812639; rs3829129; rs4638254; rs4746176; rs6480720; rs7071701; rs7079959; rs7099159; rs733350; rs7896323

# Metabolic_Enzyme_10_General_References:
8577746; 8917457; 9070863; 9843365; 12112843

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5937

# Metabolic_Enzyme_11_Name:
Adenosine deaminase

# Metabolic_Enzyme_11_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_11_Gene_Name:
ADA

# Metabolic_Enzyme_11_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_11_Number_of_Residues:
363

# Metabolic_Enzyme_11_Molecular_Weight:
40765

# Metabolic_Enzyme_11_Theoretical_pI:
5.80

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_11_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_11_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_11_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_11_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_11_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
ADA

# Metabolic_Enzyme_11_Geneatlas_id:
ADA

# Metabolic_Enzyme_11_hgnc_id:
HGNC:186

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_11_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_11_Locus:
20q12-q13.11

# Metabolic_Enzyme_11_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_11_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5236

# Metabolic_Enzyme_12_Name:
5'(3')-deoxyribonucleotidase, mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
5',3'-nucleotidase, mitochondrial; Deoxy-5'-nucleotidase 2; dNT-2

# Metabolic_Enzyme_12_Gene_Name:
NT5M

# Metabolic_Enzyme_12_Protein_Sequence:
>5'3'deoxyribonucleotidase, mitochondrial precursor
MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMAS
LQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDI
TGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

# Metabolic_Enzyme_12_Number_of_Residues:
228

# Metabolic_Enzyme_12_Molecular_Weight:
25862

# Metabolic_Enzyme_12_Theoretical_pI:
8.12

# Metabolic_Enzyme_12_GO_Classification:
Not Available

# Metabolic_Enzyme_12_General_Function:
Not Available

# Metabolic_Enzyme_12_Specific_Function:
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

# Metabolic_Enzyme_12_Pathway:
Not Available

# Metabolic_Enzyme_12_Reaction:
Not Available

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF06941:NT5C

# Metabolic_Enzyme_12_Signals:
1-15

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_12_GenBank_ID_Protein:
9408106

# Metabolic_Enzyme_12_SwissProt_ID:
NT5M_HUMAN (Q9NPB1)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
NT5M

# Metabolic_Enzyme_12_Geneatlas_id:
NT5M

# Metabolic_Enzyme_12_hgnc_id:
HGNC:15769

# Metabolic_Enzyme_12_PDB_ID:
1Q92

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_12_Gene_Sequence:
>687 bp
ATGATCCGGCTGGGCGGCTGGTGTGCGCGGCGGCTCTGCAGCGCGGCGGTTCCCGCGGGG
CGGCGCGGGGCGGCGGGCGGGCTGGGCCTGGCGGGAGGCCGCGCCCTACGGGTGCTGGTG
GACATGGACGGCGTGCTGGCTGACTTCGAGGGCGGATTCCTCAGGAAGTTCCGCGCGCGC
TTTCCCGACCAGCCCTTCATCGCGCTGGAGGACCGGCGCGGCTTCTGGGTGTCGGAGCAG
TACGGCCGCCTGCGGCCAGGGCTGAGCGAGAAGGCCATCAGCATTTGGGAGTCAAAGAAT
TTCTTTTTTGAACTTGAGCCTCTGCCAGGGGCCGTGGAAGCTGTCAAGGAGATGGCCAGC
CTACAAAACACTGACGTCTTCATCTGCACAAGCCCCATCAAGATGTTCAAGTACTGTCCC
TATGAGAAGTATGCCTGGGTGGAGAAGTACTTTGGCCCTGACTTTCTGGAGCAGATTGTG
CTGACCAGAGACAAGACCGTGGTCTCTGCTGACCTTCTCATAGACGACCGGCCGGACATC
ACAGGGGCCGAGCCAACCCCCAGCTGGGAGCATGTCCTCTTCACCGCCTGCCACAACCAG
CACCTGCAGCTGCAGCCCCCCCGCCGCAGGCTGCACTCGTGGGCGGACGACTGGAAGGCC
ATTCTGGACAGCAAGCGGCCCTGCTGA

# Metabolic_Enzyme_12_GenBank_ID_Gene:
AJ277557

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_12_Locus:
17p11.2

# Metabolic_Enzyme_12_SNPs:
rs2240876; rs758742; rs1860553; rs242243; rs6502579; rs7223473; rs11078384; rs7226068; rs10468464; rs12948296; rs1860552; rs9912109; rs9898622; rs7211968; rs17726703; rs9914692; rs3785502; rs11867932; rs3785504; rs17726673; rs11654778; rs16942153; rs17726858; rs11078382; rs3826302; rs2064060; rs6502580; rs7217503; rs9912172; rs3785506; rs9908168; rs11652902; rs9902505; rs4985707; rs6502576; rs6502578; rs16961564; rs7210344; rs16961516; rs242242; rs171394; rs12600778; rs9909111; rs7219752; rs6502577; rs12601631; rs11869054; rs17726924; rs9891799; rs11870836; rs11869507; rs11078383; rs4985706; rs7217162; rs9889738; rs9908338; rs7222555; rs9915883; rs7211243; rs9916133; rs9907857; rs9905836; rs11657817; rs9889298; rs7220829; rs9903425; rs9908360; rs9914424; rs9908124; rs11650700; rs11869079; rs7212369; rs9889367; rs7217114; rs9896977; rs9916676; rs16961561; rs12602026; rs9896970; rs9904396; rs9909850; rs10852849; rs11078385; rs6502575; rs242244; rs16961576; rs3203918; rs8082383; rs7212012; rs36114962; rs9889834; rs7226045; rs12602003; rs9894669; rs35712658; rs12941075; rs7210625; rs35320589; rs11655849; rs35470335; rs34668117; rs12943271; rs34446504; rs35945070; rs34219219; rs12951176; rs35554631; rs34408375; rs28825184; rs7218566; rs35917484; rs28880443; rs9904393; rs12601106; rs34579357; rs4985765; rs9907711; rs11343472; rs35579933; rs3087093; rs12951985; rs34993127; rs36088408; rs36091965; rs34100977; rs7220057; rs8080335; rs9901325; rs35720826; rs34886391; rs12949216; rs9898993; rs34121330; rs34513135; rs12936127; rs8067236; rs8081939; rs10617184; rs7211790; rs9914209; rs12951519; rs12603230; rs9913775; rs8068408; rs12452455; rs9901373; rs3063349; rs9913682; rs3785503; rs34156759; rs34776810; rs10574223; rs34836173; rs12951434; rs9709057; rs28813401; rs36146846; rs34709982; rs28616155; rs8082379; rs35267848; rs12951289; rs12948357; rs12950577; rs35861887; rs12948747; rs35096596; rs8080408; rs9898042; rs35930947; rs12948751; rs5741757; rs9889355; rs35575792; rs34018072; rs34407368; rs4985764; rs11395505; rs34676851; rs12951504; rs12950929; rs34025151; rs3837806; rs34247865; rs12946386; rs34209605; rs7219953; rs12951983; rs11400183; rs9912599; rs36056059; rs8071972; rs35039203; rs35326975; rs8071718; rs12946113; rs1009720; rs10852850; rs11078381; rs11078386; rs11871699; rs12450758; rs12451886; rs12452946; rs12602578; rs16961593; rs16961599; rs17648393; rs183596; rs190261; rs2041393; rs2058292; rs2191383; rs242246; rs242247; rs242249; rs242250; rs242251; rs624242; rs6502572; rs8067390; rs9892592; rs9899615; rs9905458; rs9909800; rs9914113

# Metabolic_Enzyme_12_General_References:
10899995; 12352955

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5233

# Metabolic_Enzyme_13_Name:
Cytosolic 5'-nucleotidase 1A

# Metabolic_Enzyme_13_Synonyms:
Cytosolic 5'-nucleotidase IA; cN1A; cN-IA; cN-I

# Metabolic_Enzyme_13_Gene_Name:
NT5C1A

# Metabolic_Enzyme_13_Protein_Sequence:
>Cytosolic 5'nucleotidase 1
AMEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSR
ALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSED
VFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKV
REAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKA
HENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSW
GLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTA
PAKQAPSAQ

# Metabolic_Enzyme_13_Number_of_Residues:
368

# Metabolic_Enzyme_13_Molecular_Weight:
41021

# Metabolic_Enzyme_13_Theoretical_pI:
6.52

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ester bonds
Function:  phosphoric ester hydrolase activity
Function:  phosphoric monoester hydrolase activity
Function:  nucleotidase activity
Function:  5'-nucleotidase activity
Function:  ion binding
Function:  metal ion binding
Function:  magnesium ion binding
Function:  binding
Function:  nucleotide binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_13_General_Function:
Not Available

# Metabolic_Enzyme_13_Specific_Function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia

# Metabolic_Enzyme_13_Pathway:
map00230  Purine metabolism;
 map00240  Pyrimidine metabolism;
 map00760  Nicotinate and nicotinamide metabolism

# Metabolic_Enzyme_13_Reaction:
A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF06189:5-nucleotidase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
None

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 3.1.3.5

# Metabolic_Enzyme_13_GenBank_ID_Protein:
12659324

# Metabolic_Enzyme_13_SwissProt_ID:
5NT1A_HUMAN (Q9BXI3)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
NT5C1A

# Metabolic_Enzyme_13_Geneatlas_id:
NT5C1A

# Metabolic_Enzyme_13_hgnc_id:
HGNC:17819

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_13_Gene_Sequence:
>1107 bp
ATGGAACCTGGGCAGCCCCGGGAGCCCCAGGAGCCCCGCGAGCCCGGGCCAGGAGCGGAG
ACCGCTGCGGCCCCGGTCTGGGAGGAAGCCAAGATTTTCTACGACAACCTCGCGCCCAAG
AAGAAACCCAAATCGCCCAAGCCTCAGAATGCAGTCACCATCGCTGTGTCCTCCCGAGCC
TTGTTTCGCATGGACGAGGAGCAGCAGATCTACACGGAGCAGGGCGTGGAGGAGTACGTG
CGCTACCAGCTGGAACATGAGAACGAACCCTTCAGTCCCGGGCCAGCCTTCCCTTTTGTG
AAGGCTCTGGAGGCCGTGAACAGGCGGCTGCGGGAGCTGTACCCTGATAGTGAGGACGTC
TTCGACATCGTCCTCATGACTAACAACCATGCTCAAGTGGGTGTCCGCCTCATCAACAGT
ATCAACCACTATGACCTGTTCATCGAGAGGTTCTGCATGACAGGTGGGAACAGCCCGATC
TGCTACCTCAAGGCCTATCACACCAACCTCTACTTGTCAGCCGATGCGGAAAAAGTGCGA
GAAGCCATTGATGAGGGGATCGCAGCTGCCACCATCTTCAGCCCCAGCAGGGATGTGGTT
GTGTCCCAGAGTCAGCTGCGCGTGGCCTTCGATGGGGACGCCGTGCTCTTCTCGGACGAG
TCGGAGCGCATCGTCAAGGCCCACGGGCTGGACCGATTCTTCGAGCATGAGAAGGCCCAC
GAGAACAAGCCTCTGGCTCAGGGCCCCTTAAAGGGCTTTCTGGAGGCACTGGGTAGGTTG
CAGAAGAAGTTCTACTCCAAAGGCCTGCGGCTGGAGTGCCCAATTCGTACCTACTTGGTG
ACAGCACGCAGTGCAGCCAGTTCCGGGGCCCGGGCTCTCAAGACCCTGCGCAGCTGGGGC
CTGGAGACAGATGAAGCCTTGTTCCTTGCTGGAGCGCCCAAGGGCCCTCTCCTTGAGAAG
ATCCGCCCACACATCTTCTTTGATGACCAGATGTTCCATGTGGCTGGGGCTCAGGAGATG
GGCACTGTGGCCGCCCATGTGCCTTATGGTGTGGCACAGACACCCCGGCGGACTGCACCT
GCAAAGCAGGCCCCATCTGCACAGTAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
AF331801

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_13_Locus:
1p34.3-p33

# Metabolic_Enzyme_13_SNPs:
rs4660340; rs784611; rs752667; rs1180272; rs1180271; rs784595; rs873917; rs1568146; rs1535031; rs3851911; rs17264901; rs784596; rs12566856; rs12406284; rs11807200; rs784597; rs784610; rs734497; rs3806428; rs784600; rs11809004; rs7553293; rs3806433; rs16826428; rs9660121; rs784599; rs3806429; rs784612; rs1533479; rs2871601; rs41264507; rs34479837; rs12035327; rs1180270; rs9439008; rs35574502; rs34779558; rs36025518; rs36123767; rs35625235; rs28507686; rs35550484; rs11206573; rs41264509; rs784598; rs34604809; rs1535030; rs5773668; rs1517187; rs12039176; rs28592113; rs784594; rs9438930; rs11306359; rs35355327; rs6684666; rs34908371; rs28667717; rs3806432; rs5773667; rs7416372; rs34045723; rs6672154; rs35002774; rs35256759; rs3806431; rs12042601; rs10465833; rs1062103; rs10839; rs10888919; rs10888929; rs11206525; rs1180275; rs1180277; rs12039225; rs12042356; rs12565281; rs13315; rs16826440; rs17501838; rs17560858; rs2281302; rs2746057; rs3207766; rs3806434; rs3916165; rs6663003; rs6703320; rs704769; rs736009; rs7419080; rs784601; rs784602; rs784613; rs784615; rs784616; rs784627; rs784629; rs784630; rs813052

# Metabolic_Enzyme_13_General_References:
11133996

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
7200

# Metabolic_Enzyme_14_Name:
Prothrombin precursor

# Metabolic_Enzyme_14_Synonyms:
Coagulation factor II[Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

# Metabolic_Enzyme_14_Gene_Name:
F2

# Metabolic_Enzyme_14_Protein_Sequence:
>Prothrombin precursor
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE

# Metabolic_Enzyme_14_Number_of_Residues:
622

# Metabolic_Enzyme_14_Molecular_Weight:
70037

# Metabolic_Enzyme_14_Theoretical_pI:
5.70

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  thrombin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C

# Metabolic_Enzyme_14_Pathway:
Not Available

# Metabolic_Enzyme_14_Reaction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF00594:Gla;
PF00051:Kringle;
PF00089:Trypsin

# Metabolic_Enzyme_14_Signals:
1-24

# Metabolic_Enzyme_14_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 3.4.21.5

# Metabolic_Enzyme_14_GenBank_ID_Protein:
339641

# Metabolic_Enzyme_14_SwissProt_ID:
THRB_HUMAN (P00734)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
F2

# Metabolic_Enzyme_14_Geneatlas_id:
F2

# Metabolic_Enzyme_14_hgnc_id:
HGNC:3535

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_14_Gene_Sequence:
>1869 bp
ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC
CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG
GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTAGAGCGAGAGTGC
GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG
GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT
GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG
AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT
GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC
GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA
TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA
GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG
TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA
CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC
TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT
GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA
GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC
CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT
CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC
GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG
CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG
GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT
GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACAAGGTACGAGCGAAACATTGAAAAG
ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC
CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT
GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG
GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC
AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC
CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA
GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC
CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT
GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT
GGAGAGTAG

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M17262

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_14_Locus:
11p11-q12

# Metabolic_Enzyme_14_SNPs:
rs5896; rs5898; rs3136452; rs3136532; rs5899; rs3136457; rs3136449; rs3136516; rs2282686; rs2070851; rs3136460; rs3136447; rs3136478; rs3136441; rs3136435; rs2070852; rs2282687; rs3136520; rs3136512; rs3136509; rs3136474; rs3136434; rs3136471; rs3136485; rs3136439; rs3136497; rs3136433; rs3136505; rs3136455; rs3136484; rs3136446; rs3136472; rs3136431; rs2070850; rs10838616; rs3136456; rs3136479; rs3136443; rs3136476; rs3136500; rs12574714; rs3136482; rs3136495; rs3136503; rs3136483; rs3136521; rs3136487; rs3136458; rs3136491; rs1799867; rs3136504; rs3136513; rs3136436; rs3136469; rs3136448; rs3136496; rs3136468; rs3136489; rs3136490; rs3136459; rs3136438; rs3136467; rs3136507; rs3136499; rs3136463; rs3136515; rs3136506; rs3136480; rs3136481; rs3136440; rs3136524; rs3136519; rs3136430; rs3136518; rs17854684; rs5897; rs1130873; rs5900; rs1799963; rs3136508; rs35768741; rs3136530; rs3136501; rs3136445; rs3136461; rs3136531; rs3136492; rs3891193; rs3136525; rs3136466; rs3136527; rs34428021; rs3136437; rs12787268; rs3136454; rs3136528; rs35690173; rs3136477; rs3136488; rs34747958; rs3136442; rs34204052; rs11038981; rs3926328; rs3136465; rs34647507; rs3136493; rs3136529; rs11038980; rs3136522; rs7123803; rs17847082; rs3136464; rs3136514; rs3926329; rs3136502; rs34284995; rs3136511; rs3136486; rs3136494; rs3136444; rs3136523; rs36050035; rs35150107; rs1129439; rs34296052; rs3136498; rs11438724; rs3136526; rs3136510; rs35817575; rs4752930; rs3136517; rs9794941; rs41275180; rs10838614; rs11038975; rs11038977; rs11038983; rs11038984; rs1130904; rs11604876; rs4076557; rs7938264

# Metabolic_Enzyme_14_General_References:
2825773; 6305407; 266717; 873923; 3759958; 2583108; 2374926; 8071320; 9214615; 10051558; 3771562; 7792730; 1421398; 7865694; 3242619; 2719946; 1354985; 3567158; 3801671; 1349838; 6405779; 10391209

# Metabolic_Enzyme_14_References:
16689530; 17150644

# Metabolic_Enzyme_15_ID:
8863

# Metabolic_Enzyme_15_Name:
CDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase

# Metabolic_Enzyme_15_Synonyms:
Not Available

# Metabolic_Enzyme_15_Gene_Name:
Not Available

# Metabolic_Enzyme_15_Protein_Sequence:
>CDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase
MYFLCFFCLFVSGRKWSRQFLLSFWCTVCSAHQGTIFLSLKIQFADQKQEFNKRPTKIGR
RSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREI
EIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIY
STLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKK
YPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDG
LKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKL
NEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVR
SQVDHVIWPDGKRIVLLAEGRLLNLSCSTMPTFVLSITATTQALALIELYNAPEGRYKQD
VYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY

# Metabolic_Enzyme_15_Number_of_Residues:
530

# Metabolic_Enzyme_15_Molecular_Weight:
59596

# Metabolic_Enzyme_15_Theoretical_pI:
8.05

# Metabolic_Enzyme_15_GO_Classification:
>>>
 Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on ether bonds
Function:  trialkylsulfonium hydrolase activity
Function:  adenosylhomocysteinase activity
 ||
>>>
 Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  one-carbon compound metabolism
 ||
>>>
 Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Coenzyme transport and metabolism

# Metabolic_Enzyme_15_Specific_Function:
S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine

# Metabolic_Enzyme_15_Pathway:
map00271  Methionine metabolism
 map00450  Selenoamino acid metabolism

# Metabolic_Enzyme_15_Reaction:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF05221:AdoHcyase
PF00670:AdoHcyase_NAD

# Metabolic_Enzyme_15_Signals:
1-31

# Metabolic_Enzyme_15_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 3.3.1.1

# Metabolic_Enzyme_15_GenBank_ID_Protein:
34527613

# Metabolic_Enzyme_15_SwissProt_ID:
Q6ZNS6_HUMAN (Q6ZNS6)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
Not Available

# Metabolic_Enzyme_15_Geneatlas_id:
Not Available

# Metabolic_Enzyme_15_hgnc_id:
Not Available

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_15_Gene_Sequence:
>1593 bp
ATGTATTTTCTCTGCTTTTTTTGTTTGTTTGTTTCAGGCAGGAAGTGGAGCCGTCAGTTC
CTGCTTTCATTCTGGTGTACTGTATGTTCTGCCCATCAAGGAACCATCTTTTTATCATTA
AAGATCCAGTTTGCTGACCAGAAGCAAGAATTCAACAAACGTCCCACCAAAATTGGACGT
CGCTCTTTGTCTCGTTCCATTTCTCAGTCATCTACTGACAGCTACAGCTCAGCGGCTTCA
TATACAGATAGCTCTGATGATGAGACATCGCCCAGGGACAAGCAGCAAAAGAACTCTAAG
GGAAGCAGTGACTTCTGTGTTAAGAACATCAAACAGGCAGAGTTTGGACGAAGAGAAATT
GAAATTGCTGAACAAGAAATGCCTGCATTGATGGCTTTGAGGAAGAGAGCTCAAGGAGAA
AAGCCTTTGGCTGGAGCCAAAATCGTGGGTTGCACACACATCACTGCTCAGACTGCTGTG
CTTATGGAAACTCTGGGTGCTCTGGGGGCCCAGTGCCGATGGGCTGCCTGCAACATCTAT
TCCACTCTCAATGAAGTGGCTGCTGCTCTAGCAGAAAGTGGATTTCCTGTTTTTGCCTGG
AAGGGAGAGTCAGAAGATGACTTTTGGTGGTGTATCGATAGATGTGTGAATGTGGAGGGC
TGGCAGCCAAACATGATCTTGGATGATGGAGGGGATCTTACCCACTGGATTTATAAAAAG
TATCCCAACATGTTTAAGAAAATCAAGGGCATAGTAGAGGAGAGTGTTACTGGAGTTCAC
AGGCTGTACCAACTGTCCAAAGCTGGGAAGCTGTGTGTTCCAGCCATGAATGTCAATGAC
TCAGTCACCAAACAGAAATTTGACAACCTCTACTGTTGCCGTGAATCAATTCTTGATGGA
CTTAAAAGGACAACAGACATGATGTTTGGTGGAAAGCAAGTGGTAGTCTGTGGCTATGGA
GAGGTGGGGAAAGGGTGCTGTGCTGCCCTGAAAGCCATGGGCTCCATTGTGTATGTAACT
GAAATTGACCCCATCTGTGCCCTGCAAGCCTGTATGGATGGATTTCGACTGGTGAAATTA
AATGAGGTCATCCGACAAGTGGACATTGTTATTACCTGTACAGGTAACAAGAATGTGGTA
ACCAGAGAGCACTTGGACCGTATGAAGAATAGCTGCATCGTTTGTAACATGGGACATTCC
AACACAGAGATTGACGTGGCGAGTCTGCGGACACCAGAACTGACCTGGGAGCGAGTGAGA
TCTCAAGTTGACCATGTGATATGGCCTGATGGCAAGAGGATAGTACTGCTGGCAGAGGGC
CGCCTGCTGAACCTTAGCTGCTCCACAATGCCTACATTTGTGCTCTCAATCACTGCTACT
ACTCAGGCTCTTGCCTTGATAGAGCTTTACAATGCTCCTGAGGGTCGCTATAAGCAGGAT
GTCTACCTGTTGCCCAAGAAGATGGATGAGTATGTGGCCAGCCTACACCTGCCTACCTTT
GATGCCCACTTGACAGAGCTGACAGATGAACAGGCCAAGTATCTGGGACTCAACAAGAAT
GGGCCCTTCAAGCCTAATTACTACAGGTATTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
AK130743

# Metabolic_Enzyme_15_Chromosome_Location:
Not Available

# Metabolic_Enzyme_15_Locus:
Not Available

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
Not Available

# Metabolic_Enzyme_15_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7549

# Macromolecular_Interacting_Partner_1_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
INS

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_1_Signals:
1-24

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
INS

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_1_Locus:
11p15.5

# Macromolecular_Interacting_Partner_1_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_1_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_1_References:
16873415

# Macromolecular_Interacting_Partner_2_ID:
7551

# Macromolecular_Interacting_Partner_2_Name:
Tumor necrosis factor precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin[Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]

# Macromolecular_Interacting_Partner_2_Gene_Name:
TNF

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Tumor necrosis factor precursor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
233

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25645

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.92

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin 1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_2_Signals:
None

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
36-56

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
Not Available

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
TNFA_HUMAN (P01375)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
TNF

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
TNF

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:11892

# Macromolecular_Interacting_Partner_2_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Cell membrane; single-pass type II membrane protein. Processed form:Secreted protein. Note=Also exists as an extracellular soluble form

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
M16441

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
3555974; 6392892; 3883195; 2995927; 3856324; 3932069; 8499947; 10202016; 8597870; 10205166; 2009860; 1402651; 9034191; 2922050; 1964681; 2551905; 9488135; 9442056

# Macromolecular_Interacting_Partner_2_References:
16778150; 16788688; 16849509; 17021714

# Macromolecular_Interacting_Partner_3_ID:
7569

# Macromolecular_Interacting_Partner_3_Name:
Interleukin-6 precursor

# Macromolecular_Interacting_Partner_3_Synonyms:
IL-6; B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF

# Macromolecular_Interacting_Partner_3_Gene_Name:
IL6

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Interleukin6 precursor
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
212

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
23718

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
6.52

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-6 receptor binding
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
IL-6 is a cytokine with a wide variety of biological functions:it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00489:IL6

# Macromolecular_Interacting_Partner_3_Signals:
1-29

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
32674

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
IL6_HUMAN (P05231)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
IL6

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
IL6

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6018

# Macromolecular_Interacting_Partner_3_PDB_ID:
2IL6

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
X04430

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_3_Locus:
7p21

# Macromolecular_Interacting_Partner_3_SNPs:
rs2069860; rs13306435; rs2069830; rs2069849; rs2069850; rs2069851; rs13306436; rs2069857; rs3087226; rs1474347; rs2069833; rs2069832; rs1554606; rs2069842; rs1548216; rs2069840; rs2066992; rs1474348; rs2069835; rs2069831; rs2069845; rs2069838; rs2069834; rs2069837; rs1524107; rs2069841; rs3087232; rs13306433; rs34277345; rs2069847; rs3087227; rs2069848; rs35361244; rs34249410; rs3087228; rs3087233; rs3087230; rs2069843; rs3087229; rs2069844; rs3087231; rs2069858; rs1800795; rs2069824; rs1800797; rs7802308; rs1800796; rs7802307; rs2069829; rs3087223; rs2069827; rs2069825; rs3087225; rs2069861; rs36215814; rs2234683; rs2069828; rs11544633; rs41477054; rs13306438; rs3915892; rs3915893; rs2069839; rs13306434; rs3087234; rs2069846; rs2069836; rs3087235; rs2069859; rs13447445; rs36215459; rs36215820; rs35081782; rs35178191; rs13447446; rs2069826; rs34328912; rs3087224; rs36215821; rs4335044; rs36215822; rs11973115; rs36215817; rs11445458; rs34224237; rs36215461; rs36215818; rs34280821; rs34012176; rs34709428; rs10242595; rs10499563; rs11766273; rs12700386; rs12700390; rs13438415; rs1546762; rs1546763; rs17147230; rs1880241; rs1880242; rs1880243; rs2069852; rs2069853; rs2069854; rs2069855; rs2069862; rs3087221; rs3087238; rs35610689; rs4398801; rs4719713; rs4719714; rs6461662; rs6946908; rs6963444; rs6963591; rs7458109; rs7784987; rs7801617; rs7805828; rs940367

# Macromolecular_Interacting_Partner_3_General_References:
3491322; 3500852; 3538015; 3023045; 3320204; 2789513; 3758081; 3266463; 1291290; 3279116; 2610854; 1883960; 7851440; 2472117; 2037043; 8555185; 9159484; 9118960

# Macromolecular_Interacting_Partner_3_References:
16788688; 16925466; 17065216

# Macromolecular_Interacting_Partner_4_ID:
7612

# Macromolecular_Interacting_Partner_4_Name:
Vascular endothelial growth factor A precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
VEGF-A; Vascular permeability factor; VPF

# Macromolecular_Interacting_Partner_4_Gene_Name:
VEGF

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Vascular endothelial growth factor A precursor
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
232

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
27043

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
9.08

# Macromolecular_Interacting_Partner_4_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  growth factor activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00341:PDGF

# Macromolecular_Interacting_Partner_4_Signals:
1-26

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
181971

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
VEGFA_HUMAN (P15692)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
VEGF

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
VEGF

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:12680

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell- associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>576 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTCGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACG
TGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAAC
GAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
M32977

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_4_Locus:
6p12

# Macromolecular_Interacting_Partner_4_SNPs:
Not Available

# Macromolecular_Interacting_Partner_4_General_References:
2479986; 2479987; 1711045; 1791831; 1567395; 9054410; 9878851; 9450968; 10464055; 14574404; 7678805; 2584205; 10067980; 9207067; 9351807; 9922142; 9336848; 9634701; 11427521

# Macromolecular_Interacting_Partner_4_References:
16682012; 16799085; 17065216

# Macromolecular_Interacting_Partner_5_ID:
6982

# Macromolecular_Interacting_Partner_5_Name:
Adenosine A2a receptor

# Macromolecular_Interacting_Partner_5_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Name:
ADORA2A

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Adenosine A2a receptor
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
412

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
44708

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.05

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A2A adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_5_General_Function:
Not Available

# Macromolecular_Interacting_Partner_5_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

# Macromolecular_Interacting_Partner_5_Pathway:
Not Available

# Macromolecular_Interacting_Partner_5_Reaction:
Not Available

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_5_Signals:
1-30

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
177892

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
AA2AR_HUMAN (P29274)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
ADORA2A

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
ADORA2A

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:263

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1230 bp
ATGGGCTCCTCGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCCATCCTGGGC
AATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACCTGCAGAACGTCACCAACTAC
TTTGTGGTGTCACTGGCGGCGGCCGACATCGCAGTGGGTGTGCTCGCCATCCCCTTTGCC
ATCACCATCAGCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATTGCCTGCTTC
GTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGGCCATCGCCATTGACCGCTAC
ATTGCCATCCGCATCCCGCTCCGGTACAATGGCTTGGTGACCGGCACGAGGGCTAAGGGC
ATCATTGCCATCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATGCTAGGTTGG
AACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCCAGGGCTGCGGGGAGGGCCAA
GTGGCCTGTCTCTTTGAGGATGTGGTCCCCATGAACTACATGGTGTACTTCAACTTCTTT
GCCTGTGTGCTGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATCTTCCTGGCG
GCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGCCGGGGGAGCGGGCACGGTCC
ACACTGCAGAAGGAGGTCCATGCTGCCAAGTCACTGGCCATCATTGTGGGGCTCTTTGCC
CTCTGCTGGCTGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCCGACTGCAGC
CACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCTCCCACACCAATTCGGTTGTG
AATCCCTTCATCTACGCCTACCGTATCCGCGAGTTCCGCCAGACCTTCCGCAAGATCATT
CGCAGCCACGTCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGTGCCCGGGTC
TTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCCGTCTCAACGGCCACCCGCCA
GGAGTGTGGGCCAACGGCAGTGCTCCCCACCCTGAGCGGAGGCCCAATGGCTATGCCCTG
GGGCTGGTGAGTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTCCCAGACGTG
GAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGCCCCCTGGCCTAGATGACCCC
CTGGCCCAGGATGGAGCAGGAGTGTCCTGA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M97370

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:22

# Macromolecular_Interacting_Partner_5_Locus:
22q11.23

# Macromolecular_Interacting_Partner_5_SNPs:
rs4990; rs17650937; rs4991; rs8192446; rs5751876; rs5996697; rs4822489; rs8184997; rs2236624; rs2267076; rs17004919; rs11704811; rs17004920; rs2236625; rs9624472; rs2330771; rs35327329; rs5760421; rs2533; rs35060421; rs35320474; rs4992; rs3211360; rs2532; rs4820587; rs5760420; rs35240883; rs17650801; rs4417803; rs34911378; rs28529486; rs4292176; rs5760418; rs7289199; rs35396475; rs34452689; rs3032740; rs10427623; rs35826617; rs13054761; rs13054390; rs34923252; rs13055638; rs13055629; rs13053574; rs1041749; rs1041750; rs11703436; rs12484115; rs13306115; rs13306116; rs17004921; rs17004922; rs17651129; rs17651189; rs2154609; rs2298382; rs2298383; rs3761421; rs3761422; rs3761423; rs3810617; rs4530; rs4822492; rs5751873; rs5751878; rs5760413; rs5760423; rs5760424; rs5760425; rs5760426; rs5760427; rs5760428; rs6004154; rs6004155; rs6004156; rs7285057; rs7287959; rs7290459; rs8141793; rs8142326; rs9612623; rs9612625; rs9624473

# Macromolecular_Interacting_Partner_5_General_References:
1331670; 8670304; 7775460; 10391209

# Macromolecular_Interacting_Partner_5_References:
16750892

# Macromolecular_Interacting_Partner_6_ID:
6980

# Macromolecular_Interacting_Partner_6_Name:
Adenosine A1 receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_6_Gene_Name:
ADORA1

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Adenosine A1 receptor
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
326

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
36512

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
8.75

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A1 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_6_Signals:
1-33

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
256155

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
AA1R_HUMAN (P30542)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
ADORA1

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
ADORA1

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:262

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>981 bp
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCGGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTCCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG

# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
S45235

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_6_Locus:
1q32.1

# Macromolecular_Interacting_Partner_6_SNPs:
rs10920568; rs1874142; rs2364571; rs722915; rs903361; rs10800899; rs6427990; rs11582098; rs9660662; rs1494487; rs6702345; rs7555556; rs11590405; rs6677740; rs10920564; rs1494486; rs12411260; rs1494490; rs6696205; rs10920565; rs16851030; rs10800900; rs2886116; rs4570461; rs10920567; rs3898276; rs7538512; rs10920563; rs17510253; rs12023876; rs1494488; rs16851029; rs16850993; rs6674385; rs12047618; rs2131946; rs12072817; rs16850986; rs1874141; rs6427994; rs12744240; rs2014975; rs2201395; rs1845466; rs1494485; rs6427992; rs11585881; rs12757387; rs3766553; rs3766562; rs10920569; rs6686206; rs6427993; rs11576067; rs4950922; rs3766554; rs6677137; rs10920570; rs3753472; rs7549561; rs6683383; rs6701725; rs1417151; rs6698262; rs11579990; rs17465037; rs12135643; rs10158980; rs3766556; rs10920576; rs10158142; rs3753474; rs3766558; rs6688884; rs1587053; rs10800901; rs3766566; rs4423076; rs3753475; rs3766557; rs3766563; rs17464408; rs4950921; rs3753476; rs3766568; rs10399916; rs12026765; rs11587584; rs17511192; rs16851020; rs4950925; rs6413919; rs2172729; rs1890871; rs3766552; rs11800284; rs3766561; rs12138660; rs3766555; rs3766560; rs3753473; rs3766565; rs12566249; rs10158984; rs903364; rs16851008; rs12125460; rs4950920; rs11587032; rs12136486; rs17530497; rs12757371; rs12565957; rs17511046; rs7526646; rs5019958; rs7534251; rs3820147; rs16851017; rs12408764; rs10920573; rs12405501; rs10157751; rs11584369; rs3766564; rs12138603; rs11809836; rs6677396; rs10920574; rs17464968; rs1587054; rs16850997; rs3820150; rs12130154; rs3820148; rs12123037; rs11586408; rs4950924; rs6664108; rs1038984; rs7518889; rs11547175; rs11547176; rs17852405; rs2275349; rs11547177; rs11547174; rs1050284; rs35673121; rs12066195; rs35065380; rs5780143; rs12409721; rs16850994; rs954806; rs4950917; rs3079463; rs12067310; rs35610383; rs33912180; rs12127566; rs36111948; rs12724787; rs11373129; rs34147469; rs12093689; rs6692698; rs35323024; rs5780142; rs34713977; rs35936566; rs34408707; rs12026488; rs35845775; rs36123492; rs4430394; rs1494491; rs12759581; rs34405666; rs35650733; rs12135560; rs10598632; rs35617965; rs34874759; rs16850988; rs3079442; rs34476525; rs35760964; rs35557495; rs11806342; rs5780146; rs35159294; rs34893060; rs12742743; rs12044096; rs35981236; rs4020533; rs1389793; rs1961523; rs34201405; rs6676588; rs5780145; rs34657450; rs12026534; rs35286135; rs35480016; rs11590508; rs34794302; rs10574623; rs3079461; rs11429865; rs35004724; rs5780144; rs35885593; rs34166511; rs35283802; rs35483433; rs36047006; rs34682542; rs12143879; rs11315020; rs34723848; rs34191726; rs12729714; rs35155873; rs5780148; rs1417152; rs34083234; rs34589848; rs11351435; rs34898677; rs34326504; rs10712199; rs10920572; rs34426152; rs35145586; rs16851026; rs35824073; rs12119124; rs35696964; rs5780147; rs34844719; rs3834026; rs12403904; rs11280590; rs35960887; rs33933471; rs12064740; rs34639219; rs34226911; rs28855175; rs11580618; rs28666464; rs34431746; rs35195607; rs1106162; rs35699427; rs34779744; rs35070050; rs34636136; rs33996239; rs34723344; rs35689603; rs34372946; rs12726499; rs35038923; rs6427991; rs28605817; rs12025716; rs34162960; rs28721870; rs34583593; rs35927797; rs36070492; rs34920887; rs5780149; rs41264023; rs10525873; rs3841801; rs35504564; rs35517847; rs1494489; rs36047406; rs36073026; rs11589430; rs34228965; rs10638251; rs11412106; rs10920575; rs3835485; rs7544471; rs7534083; rs12095257; rs7544486; rs34457723; rs9659544; rs11373990; rs10753935; rs10920562; rs11588424; rs11807924; rs12028355; rs12070378; rs12087754; rs12097720; rs12139072; rs12145010; rs12724763; rs12737716; rs12743504; rs1532324; rs16851032; rs17465574; rs1999926; rs2071013; rs2071452; rs2250509; rs2642531; rs2642532; rs2788527; rs2788528; rs2788529; rs2791718; rs2791719; rs2791720; rs2814499; rs2855402; rs2855403; rs33945931; rs34702760; rs3737872; rs3737873; rs3737874; rs3737875; rs3737876; rs3737877; rs3737878; rs3753470; rs3753477; rs3753483; rs3766547; rs3766548; rs3766549; rs3766550; rs3766551; rs3820149; rs4950877; rs4950926; rs7514834; rs7538338; rs7545750; rs762625; rs883125; rs903356; rs923950

# Macromolecular_Interacting_Partner_6_General_References:
1530647; 1339301; 8300646

# Macromolecular_Interacting_Partner_6_References:
17039775; 17041727

# Macromolecular_Interacting_Partner_7_ID:
6985

# Macromolecular_Interacting_Partner_7_Name:
Adenosine A3 receptor

# Macromolecular_Interacting_Partner_7_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_7_Gene_Name:
ADORA3

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Adenosine A3 receptor
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
318

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
36185

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
9.04

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor activity
Function:  transmembrane receptor activity
Function:  G-protein coupled receptor activity
Function:  rhodopsin-like receptor activity
Function:  nucleotide receptor activity, G-protein coupled
Function:  purinergic nucleotide receptor activity, G-protein coupled
Function:  adenosine receptor activity, G-protein coupled
Function:  A3 adenosine receptor activity, G-protein coupled
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00001:7tm_1

# Macromolecular_Interacting_Partner_7_Signals:
None

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
15-37
49-72
85-106
127-148
178-198
232-255
262-284

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
349449

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
AA3R_HUMAN (P33765)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
ADORA3

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
ADORA3

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:268

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>957 bp
ATGCCCAACAACAGCACTACTCTGTCATTGGCCAATGTTACCTACATCACCATGGAAATT
TTCATTGGACTCTGCGCCATAGTGGGCAACGTGCTGGTCATCTGCGTGGTCAAGCTGAAC
CCCAGCCTGCAGACCACCACCTTCTATTTCATTGTCTCTCTAGCCCTGGCTGACATTGCT
GTTGGGGTGCTGGTCATGCCTTTGGCCATTGTTGTCAGCCTGGGCATCACAATCCACTTC
TACAGCTGCCTTTTTATGACTTGCCTACTGCTTATCTTTACCCACGCCTCCATCATGTCC
TTGCTGGCCATCGCTGTGGACCGATACTTGCGGGTCAAGCTTACCGTCAGATACAAGAGG
GTCACCACTCACAGAAGAATATGGCTGGCCCTGGGCCTTTGCTGGCTGGTGTCATTCCTG
GTGGGATTGACCCCCATGTTTGGCTGGAACATGAAACTGACCTCAGAGTACCACAGAAAT
GTCACCTTCCTTTCATGCCAATTTGTTTCCGTCATGAGAATGGACTACATGGTATACTTC
AGCTTCCTCACCTGGATTTTCATCCCCCTGGTTGTCATGTGCGCCATCTATCTTGACATC
TTTTACATCATTCGGAACAAACTCAGTCTGAACTTATCTAACTCCAAAGAGACAGGTGCA
TTTTATGGACGGGAGTTCAAGACGGCTAAGTCCTTGTTTCTGGTTCTTTTCTTGTTTGCT
CTGTCATGGCTGCCTTTATCTATCATCAACTGCATCATCTACTTTAATGGTGAGGTACCA
CAGCTTGTGCTGTACATGGGCATCCTGCTGTCCCATGCCAACTCCATGATGAACCCTATC
GTCTATGCCTATAAAATAAAGAAGTTCAAGGAAACCTACCTTTTGATCCTCAAAGCCTGT
GTGGTCTGCCATCCCTCTGATTCTTTGGACACAAGCATTGAGAAGAATTCTGAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
L20463

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:1

# Macromolecular_Interacting_Partner_7_Locus:
1p13.2

# Macromolecular_Interacting_Partner_7_SNPs:
rs2800889; rs35511654; rs2275797; rs2229155; rs1415792; rs1415793; rs923; rs1544223; rs3394; rs1544224; rs3393; rs7737; rs9025; rs2252739; rs2800907; rs2065992; rs1361134; rs2798566; rs2800898; rs2800908; rs2095731; rs3767602; rs7547951; rs7544118; rs1361133; rs1780556; rs6684144; rs7517018; rs12127443; rs2275796; rs17027794; rs6672858; rs6537702; rs3767601; rs1361135; rs2789539; rs2252740; rs2800888; rs6659177; rs3767597; rs2032007; rs17027796; rs2789541; rs1628597; rs7549031; rs2262952; rs2252198; rs2800906; rs3767599; rs2252197; rs2032006; rs1962125; rs2800902; rs2786996; rs10857885; rs10857886; rs10857887; rs10776728; rs11102286; rs2298191; rs10776727; rs17027791; rs35986308; rs2789537; rs17852706; rs35789323; rs1417372; rs1591993; rs41282520; rs3908963; rs41282522; rs2298190; rs2789540; rs7512445; rs10697750; rs11434724; rs11434889; rs11434726; rs12137500; rs34799830; rs11434722; rs11804136; rs28651435; rs11311759; rs6660209; rs41282516; rs12125678; rs12126504; rs6678079; rs10697753; rs35262507; rs11321711; rs10602162; rs11434888; rs11337394; rs35344043; rs34457698; rs35537319; rs6668383; rs10686710; rs10697749; rs11434890; rs34492052; rs34460629; rs10596470; rs11434725; rs35259782; rs10686711; rs10602166; rs10602160; rs35611547; rs10697748; rs10618863; rs2486265; rs41290394; rs12136686; rs28528074; rs10614217; rs11434892; rs35767792; rs12126471; rs7548753; rs35584333; rs11434723; rs1780557; rs10602164; rs3831359; rs11273132; rs28760561; rs34567608; rs34093957; rs34272338; rs10686709; rs10602163; rs10686708; rs28757604; rs41282518; rs10614218; rs11434891; rs2488943; rs35689000; rs34693250; rs11314583; rs3835605; rs2265691; rs11102285; rs3216055; rs34273340; rs10711590; rs3904838; rs34622560; rs5777061; rs35606913; rs34225315; rs35077141; rs1054680; rs10857888; rs10857889; rs10857890; rs11102281; rs11102284; rs11102290; rs11102291; rs11102292; rs11576988; rs11810580; rs12039025; rs12042310; rs12142663; rs12566343; rs1361136; rs1419091; rs1538251; rs17027773; rs17027867; rs17027880; rs2211494; rs2298189; rs2786992; rs2786994; rs2786995; rs2800886; rs4593826; rs4839139; rs6537704; rs6537705; rs6692745; rs6703267

# Macromolecular_Interacting_Partner_7_General_References:
8399349; 8234299; 12975309; 11214319

# Macromolecular_Interacting_Partner_7_References:
16805847; 16956430

# Macromolecular_Interacting_Partner_8_ID:
7828

# Macromolecular_Interacting_Partner_8_Name:
Orexin precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
Hypocretin; Hcrt[Contains: Orexin-A; Hypocretin- 1; Hcrt1; Orexin-B; Hypocretin-2; Hcrt2]

# Macromolecular_Interacting_Partner_8_Gene_Name:
HCRT

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Orexin precursor
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHA
AGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAA
ASVAPGGQSGI

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
131

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
13363

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
11.35

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  response to stimulus
Process:  behavior
Process:  feeding behavior
Process:  cellular process
Process:  cell communication
Process:  signal transduction
Process:  cell surface receptor linked signal transduction
Process:  G-protein coupled receptor protein signaling pathway
Process:  neuropeptide signaling pathway
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF02072:Orexin

# Macromolecular_Interacting_Partner_8_Signals:
1-33

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
2897118

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
OREX_HUMAN (O43612)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
HCRT

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
HCRT

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:4847

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Endoplasmic reticulum; rough endoplasmic reticulum. Cytoplasmic vesicle (By similarity). Cell junction; synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity)

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>396 bp
ATGAACCTTCCTTCCACAAAGGTCTCCTGGGCCGCCGTGACGCTACTGCTGCTGCTGCTG
CTGCTGCCGCCCGCGCTGTTGTCGTCCGGGGCGGCTGCACAGCCCCTGCCCGACTGCTGT
CGTCAAAAGACTTGCTCTTGCCGCCTCTACGAGCTGCTGCACGGCGCGGGCAATCACGCG
GCCGGCATCCTCACGCTGGGCAAGCGGAGGTCCGGGCCCCCGGGCCTCCAGGGTCGGCTG
CAGCGCCTCCTGCAGGCCAGCGGCAACCACGCCGCGGGCATCCTGACCATGGGCCGCCGC
GCAGGCGCAGAGCCAGCGCCGCGCCCCTGCCTCGGGCGCCGCTGTTCCGCCCCGGCCGCC
GCCTCCGTCGCGCCCGGAGGACAGTCCGGGATCTGA

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
AF041240

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_8_Locus:
17q21

# Macromolecular_Interacting_Partner_8_SNPs:
rs9902709; rs8072099; rs8072081; rs760282; rs41513044; rs4796777; rs34727363; rs3760391; rs748442; rs34801573; rs748443; rs28879196; rs28696012; rs12953110; rs35725938; rs748444; rs3760390; rs36046844; rs4796776; rs1453402; rs28863552; rs5820451; rs34171118; rs34640131; rs12450953; rs12603630; rs2293153; rs3744485; rs3785901; rs7226205; rs9896975; rs9905193

# Macromolecular_Interacting_Partner_8_General_References:
9491897; 10364220; 10583376; 11340621; 11283317; 10973318

# Macromolecular_Interacting_Partner_8_References:
17093123

# Macromolecular_Interacting_Partner_9_ID:
7916

# Macromolecular_Interacting_Partner_9_Name:
Interleukin-4 precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra

# Macromolecular_Interacting_Partner_9_Gene_Name:
IL4

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Interleukin4 precursor
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
17492

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
9.16

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  hematopoietin/interferon-class (D200-domain) cytokine receptor binding
Function:  interleukin-4 receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00727:IL4

# Macromolecular_Interacting_Partner_9_Signals:
1-24

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
307061

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
IL4_HUMAN (P05112)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
IL4

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
IL4

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6014

# Macromolecular_Interacting_Partner_9_PDB_ID:
1IAR

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>462 bp
ATGGGTCTCACCTCCCAACTGCTTCCCCCTCTGTTCTTCCTGCTAGCATGTGCCGGCAAC
TTTGTCCACGGACACAAGTGCGATATCACCTTACAGGAGATCATCAAAACTTTGAACAGC
CTCACAGAGCAGAAGACTCTGTGCACCGAGTTGACCGTAACAGACATCTTTGCTGCCTCC
AAGAACACAACTGAGAAGGAAACCTTCTGCAGGGCTGCGACTGTGCTCCGGCAGTTCTAC
AGCCACCATGAGAAGGACACTCGCTGCCTGGGTGCGACTGCACAGCAGTTCCACAGGCAC
AAGCAGCTGATCCGATTCCTGAAACGGCTCGACAGGAACCTCTGGGGCCTGGCGGGCTTG
AATTCCTGTCCTGTGAAGGAAGCCAACCAGAGTACGTTGGAAAACTTCTTGGAAAGGCTA
AAGACGATCATGAGAGAGAAATATTCAAAGTGTTCGAGCTGA

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M13982

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:5

# Macromolecular_Interacting_Partner_9_Locus:
5q31.1

# Macromolecular_Interacting_Partner_9_SNPs:
rs4986964; rs2243251; rs35648164; rs2070874; rs17772853; rs2227282; rs2227284; rs2243267; rs2243266; rs2243268; rs2243270; rs2243289; rs734244; rs2243258; rs2243253; rs9282745; rs2243290; rs2243274; rs2243288; rs2243261; rs2243279; rs2243252; rs2243276; rs2243259; rs2243285; rs2243269; rs2243277; rs2243260; rs2243255; rs2243283; rs2243281; rs2243263; rs2243264; rs2243286; rs2243256; rs2243275; rs9282746; rs2243284; rs2243282; rs2243250; rs2243248; rs2243247; rs2243246; rs2243249; rs4986963; rs2243238; rs2243243; rs10080170; rs2243242; rs2243245; rs2243307; rs2243240; rs2243244; rs2243257; rs35505814; rs2243262; rs2243308; rs2243271; rs2243272; rs34015525; rs2243280; rs2243278; rs34810562; rs12521281; rs9327637; rs2243309; rs2079102; rs35071211; rs6879348; rs10588641; rs28478089; rs7703922; rs9327636; rs11479198; rs34779821; rs3831509; rs35604055; rs41403547; rs2243287; rs2243265; rs2243273; rs35171620; rs4996002; rs41420944; rs34008602; rs2243241; rs10065221; rs34185442; rs10058157; rs34142320; rs35819063; rs2243239; rs34299499; rs2234648; rs2243306; rs11242122; rs11242123; rs1295682; rs2243202; rs2243204; rs2243205; rs2243206; rs2243207; rs2243208; rs2243209; rs2243210; rs2243211; rs2243212; rs2243213; rs2243217; rs2243218; rs2243219; rs2243220; rs2243222; rs2243225; rs2243226; rs2243231; rs2243232; rs2243235; rs2243291; rs2243292; rs2243298; rs2243299; rs2243300; rs2243301; rs2243302; rs2406539; rs36017530; rs4426908; rs743555

# Macromolecular_Interacting_Partner_9_General_References:
3016727; 2535858; 7806280; 3257560; 1993171; 1400355; 1511746; 10219247; 1932028; 1569578; 1567880; 1567881; 1609277; 1946344; 8151703; 7664036

# Macromolecular_Interacting_Partner_9_References:
16670768; 16707627

# Macromolecular_Interacting_Partner_10_ID:
8452

# Macromolecular_Interacting_Partner_10_Name:
Lymphotoxin-beta

# Macromolecular_Interacting_Partner_10_Synonyms:
LT-beta; Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

# Macromolecular_Interacting_Partner_10_Gene_Name:
LTB

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Lymphotoxinbeta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
244

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
25390

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
5.02

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  cytokine activity
Function:  tumor necrosis factor receptor binding
 ||
>>>
Process:  response to stimulus
Process:  response to biotic stimulus
Process:  defense response
Process:  immune response
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF00229:TNF

# Macromolecular_Interacting_Partner_10_Signals:
1-35

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
292279

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
TNFC_HUMAN (Q06643)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
LTB

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
LTB

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:6711

# Macromolecular_Interacting_Partner_10_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Membrane; single-pass type II membrane protein (Potential)

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
L11016

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_10_Locus:
6p21.3

# Macromolecular_Interacting_Partner_10_SNPs:
Not Available

# Macromolecular_Interacting_Partner_10_General_References:
7916655; 9299492; 10202016

# Macromolecular_Interacting_Partner_10_References:
16738813; 16832713; 16849509; 16885379

# Macromolecular_Interacting_Partner_11_ID:
8202

# Macromolecular_Interacting_Partner_11_Name:
Collagen alpha-1(XIII) chain

# Macromolecular_Interacting_Partner_11_Synonyms:
COLXIIIA1

# Macromolecular_Interacting_Partner_11_Gene_Name:
COL13A1

# Macromolecular_Interacting_Partner_11_Protein_Sequence:
>Collagen alpha1XIII chain
MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLPSPGSCGLLTLALCSLALSLL
AHFRTAELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCP
PGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIGPRGPPGQPGTRGFPGFPGPIGLD
GKPGHPGPKGDMGLTGPPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQIIALKLL
PLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGPPGPPGPSGPLGHPGLPGPMGPPGLPG
PPGPKGDPGIQGYHGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTKGEKGAEGS
PGLPGLLGQKGEKGDAGNSIGGGRGEPGPPGLPGPPGPKGEAGVDGQVGPPGQPGDKGER
GAAGEQGPDGPKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGI
PGQKGEIGLPGPPGHDGEKGPRGKPGDMGPPGPQGPPGKDGPPGVKGENGHPGSPGEKGE
KGETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPGPKGEAGLDGAKGEK
GFQGEKGDRGPLGLPGASGLDGRPGPPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAA
GLPGLHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK

# Macromolecular_Interacting_Partner_11_Number_of_Residues:
717

# Macromolecular_Interacting_Partner_11_Molecular_Weight:
69951

# Macromolecular_Interacting_Partner_11_Theoretical_pI:
9.82

# Macromolecular_Interacting_Partner_11_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
Process:  ion transport
Process:  anion transport
Process:  inorganic anion transport
Process:  phosphate transport
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Macromolecular_Interacting_Partner_11_General_Function:
Translation, ribosomal structure and biogenesis 

# Macromolecular_Interacting_Partner_11_Specific_Function:
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin

# Macromolecular_Interacting_Partner_11_Pathway:
Not Available

# Macromolecular_Interacting_Partner_11_Reaction:
Not Available

# Macromolecular_Interacting_Partner_11_Pfam_Domain_Function:
PF01391:Collagen

# Macromolecular_Interacting_Partner_11_Signals:
None

# Macromolecular_Interacting_Partner_11_Transmembrane_Regions:
45-61

# Macromolecular_Interacting_Partner_11_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_11_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_11_GenBank_ID_Protein:
9650749

# Macromolecular_Interacting_Partner_11_SwissProt_ID:
CODA1_HUMAN (Q5TAT6)

# Macromolecular_Interacting_Partner_11_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_11_Genecard_id:
COL13A1

# Macromolecular_Interacting_Partner_11_Geneatlas_id:
COL13A1

# Macromolecular_Interacting_Partner_11_hgnc_id:
HGNC:2190

# Macromolecular_Interacting_Partner_11_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_11_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_11_Subcellular_Location:
Cell membrane; single-pass type II membrane protein

# Macromolecular_Interacting_Partner_11_Gene_Sequence:
>2154 bp
ATGGTAGCGGAGCGCACCCACAAAGCGGCAGCCACCGGTGCCCGCGGCCCTGGGGAGTTG
GGCGCGCCCGGGACGGTGGCTCTGGTGGCGGCGCGGGCGGAGCGCGGCGCACGGCTGCCG
AGTCCAGGGTCGTGCGGGCTGCTGACGCTGGCCCTCTGCTCGCTGGCACTCAGCCTGCTC
GCCCACTTTCGGACGGCCGAGCTGCAGGCCCGGGTGCTGCGCCTGGAAGCGGAGCGCGGG
GAGCAGCAAATGGAGACAGCTATTTTGGGACGAGTCAATCAACTGCTGGACGAGAAATGG
AAGCTCCACTCAAGGAGGCGCCGGGAGGCCCCAAAGACATCTCCAGGATGTAACTGCCCA
CCAGGACCTCCTGGTCCCACTGGAAGACCCGGACTCCCAGGGGACAAAGGTGCCATTGGG
ATGCCTGGACGTGTGGGGTCCCCCGGAGACGCTGGGCTGTCCATCATTGGTCCCCGCGGC
CCCCCTGGTCAACCAGGCACTAGAGGTTTCCCTGGATTTCCGGGTCCCATTGGGCTGGAC
GGCAAACCGGGCCACCCAGGACCAAAGGGCGACATGGGTCTGACGGGTCCCCCAGGACAG
CCGGGACCCCAGGGACAAAAAGGAGAAAAGGGTCAGTGTGGAGAGTACCCACACCGGGAG
TGCCTAAGCAGCATGCCAGCAGCTCTGCGCTCCAGCCAGATAATTGCCCTGAAGCTGCTG
CCTCTCCTCAATTCAGTGCGACTGGCTCCACCCCCGGTCATAAAAAGGCGGACATTCCAG
GGCGAACAGAGCCAGGCCAGCATCCAAGGTCCACCAGGGCCCCCAGGCCCCCCTGGACCA
AGTGGACCTCTGGGGCACCCAGGACTGCCAGGGCCTATGGGGCCACCTGGCTTACCTGGG
CCTCCTGGACCAAAGGGAGACCCAGGGATCCAGGGCTACCACGGCCGGAAGGGAGAACGG
GGCATGCCAGGGATGCCAGGCAAGCATGGAGCCAAGGGGGCGCCCGGAATTGCCGTGGCT
GGGATGAAGGGTGAGCCAGGGATCCCAGGAACCAAGGGTGAGAAGGGGGCTGAAGGCTCC
CCTGGGCTTCCTGGCCTCCTGGGGCAGAAGGGAGAGAAAGGCGATGCTGGCAACTCCATT
GGAGGAGGCAGAGGGGAACCTGGCCCTCCAGGGCTCCCTGCGCCCCCAGGGCCAAAGGGA
GAAGCAGGTGTCGATGGCCAGGTTGGCCCCCCAGGGCAGCCAGGAGACAAGGGGGAGCGT
GGAGCAGCTGGAGAACAGGGACCAGATGGCCCCAAGGGCTCCAAGGGAGAACCAGGGAAA
GGAGAGATGGTGGATTACAATGGAAACATCAATGAGGCTCTCCAGGAGATCCGGACGCTG
GCCTTGATGGGGCCTCCTGGTCTTCCTGGGCAAATTGGCCCACCTGGAGCTCCAGGGATT
CCAGGCCAGAAGGGGGAGATTGGACTGCCAGGCCCTCCAGGACACGATGGGGAAAAGGGA
CCTCGCGGTAAACCAGGAGACATGGGCCCTCCTGGTCCCCAAGGCCCCCCAGGAAAGGAT
GGACCTCCAGGAGTGAAGGGAGAAAACGGGCACCCAGGGAGCCCAGGAGAGAAGGGGGAA
AAAGGGGAGACAGGACAAGCAGGCTCACCGGGAGAGAAAGGAGAAGCCGGGGAGAAGGGC
AATCCAGGAGCAGAGGTTCCTGGGCTGCCAGGGCCAGAGGGGCCTCCCGGACCTCCGGGG
CTCCAAGGTGTTCCTGGACCAAAGGGGGAAGCAGGACTAGATGGAGCAAAAGGAGAGAAA
GGCTTCCAGGGAGAAAAAGGAGACCGTGGTCCCCTGGGACTACCCGGAGCTTCAGGTTTG
GACGGCAGGCCTGGGCCACCGGGTACTCCAGGACCAATTGGAGTTCCAGGCCCAGCGGGA
CCAAAGGGCGAGAGGGGCAGCAAAGGAGACCCTGGGATGACAGGACCAACGGGAGCAGCT
GGGCTTCCTGGTTTACATGGACCACCCGGGGACAAGGGAAACCGGGGGGAGAGGGGGAAG
AAAGGCTCTAGAGGGCCTAAAGGGGACAAGGGAGACCAAGGAGCGCCTGGATTAGATGCC
CCCTGCCCATTGGGCGAAGATGGCTTACCAGTCCAAGGCTGCTGGAACAAGTGA

# Macromolecular_Interacting_Partner_11_GenBank_ID_Gene:
AJ293624

# Macromolecular_Interacting_Partner_11_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_11_Locus:
10q22

# Macromolecular_Interacting_Partner_11_SNPs:
rs1061954; rs11816811; rs1227746; rs1227747; rs2274181; rs2395272; rs1061966; rs2704505; rs2894303; rs1227763; rs1227753; rs2763349; rs1227764; rs2683563; rs2683546; rs999705; rs2683561; rs1227780; rs942569; rs2683562; rs1227775; rs999706; rs2763341; rs1149692; rs2763352; rs1227769; rs942567; rs942576; rs2763356; rs1149697; rs2395278; rs1227756; rs2683560; rs1227766; rs2704479; rs3858155; rs11593153; rs7068393; rs3852445; rs2704526; rs2763339; rs2683556; rs4746009; rs942568; rs3750777; rs4746015; rs1227739; rs1227748; rs3858156; rs2763337; rs3858153; rs10823437; rs7090294; rs1227771; rs7101190; rs3957150; rs10762320; rs1227772; rs1227751; rs7079962; rs10999050; rs10823444; rs4076957; rs1227758; rs4096394; rs4746922; rs4746939; rs11814115; rs1227762; rs2704522; rs2683575; rs2763359; rs4746925; rs4746937; rs10823450; rs2763368; rs2704494; rs4746936; rs10999018; rs4468240; rs2395280; rs3750778; rs2704523; rs4746921; rs12146165; rs10762314; rs1228671; rs7914023; rs2763363; rs2704527; rs2683571; rs3812701; rs10823449; rs3843585; rs1228670; rs7900421; rs4096395; rs11814083; rs3847353; rs10762324; rs8181302; rs1227779; rs3855625; rs2763362; rs4746013; rs3793814; rs7071359; rs4341432; rs3793830; rs2394615; rs3793832; rs1149701; rs7907056; rs7077164; rs12259074; rs2637230; rs7076867; rs4096393; rs2683555; rs3847351; rs4082516; rs10762322; rs2763360; rs2763367; rs2763357; rs3858154; rs2763334; rs2274182; rs10762318; rs3793833; rs4746934; rs1915458; rs2763336; rs12571041; rs2763355; rs3858160; rs2763342; rs10823451; rs7079971; rs10999043; rs3793829; rs10999024; rs11599139; rs11818280; rs7070915; rs12768901; rs3793819; rs3998144; rs16927087; rs10762317; rs10823448; rs10823445; rs1227759; rs2683557; rs3793821; rs10998995; rs2683548; rs4746935; rs3886895; rs4117554; rs10999021; rs2985537; rs3793818; rs12415993; rs3750776; rs2704484; rs7096311; rs16927103; rs1227765; rs10999016; rs11598108; rs2395275; rs10466015; rs2683576; rs11599021; rs2274180; rs3793822; rs10823436; rs1227768; rs2763353; rs10762321; rs16926957; rs7088833; rs2894305; rs11817033; rs942575; rs3750779; rs17497293; rs12252215; rs16927034; rs10998993; rs10999015; rs1227773; rs10823443; rs3812702; rs12251464; rs10823435; rs10823439; rs1227776; rs2894304; rs10762311; rs2704520; rs2704495; rs3750780; rs11816683; rs4746010; rs10999029; rs17497526; rs11813062; rs2683547; rs2704521; rs11598684; rs11817122; rs11595284; rs7080527; rs1227777; rs1873456; rs10998997; rs11595524; rs2763366; rs11817889; rs10998998; rs17584162; rs2704481; rs3750781; rs10999011; rs7071338; rs1227785; rs2763346; rs4746920; rs2642568; rs11595112; rs10999004; rs3886687; rs3793825; rs10998990; rs3847350; rs7100913; rs7091179; rs2637229; rs2704480; rs7091292; rs12415220; rs11813044; rs16927080; rs2763350; rs12146341; rs3793815; rs942571; rs3858157; rs2395235; rs7089663; rs4746938; rs3864816; rs3750782; rs3998148; rs1227744; rs3858161; rs10509315; rs12573027; rs2683553; rs10998979; rs4746012; rs2763345; rs3793831; rs16927048; rs2274179; rs17591282; rs4746912; rs3108964; rs942570; rs11814131; rs4082517; rs10823440; rs4746005; rs7094009; rs11592327; rs2683573; rs3793828; rs12412836; rs4746933; rs4746014; rs10998988; rs12571699; rs2683572; rs12573749; rs1234901; rs12777389; rs2683549; rs10823438; rs12220380; rs7091714; rs16926919; rs3829179; rs10823446; rs2704504; rs7910409; rs4746913; rs10733856; rs10999052; rs1227770; rs2763358; rs4746924; rs7899044; rs10999000; rs7088371; rs12355979; rs2683569; rs7087970; rs10998983; rs12357925; rs7075291; rs12412354; rs16926941; rs3750775; rs7897729; rs2704503; rs11817874; rs10999039; rs2395286; rs1227613; rs2894302; rs1125133; rs1149694; rs12780426; rs7914826; rs10999044; rs4746008; rs4746927; rs2704483; rs10999035; rs1227738; rs12249491; rs17500311; rs2395279; rs1227737; rs12357738; rs2894279; rs11592923; rs7903891; rs12357978; rs12249289; rs7903431; rs11593788; rs2763365; rs12146229; rs12146228; rs2704486; rs3936738; rs11593158; rs12358790; rs9633587; rs1227786; rs10999038; rs2894301; rs12241227; rs10999017; rs11818730; rs10999037; rs7913945; rs2683565; rs7073593; rs7069098; rs16927097; rs12573478; rs3793823; rs7902825; rs12146250; rs12146381; rs11595545; rs2763340; rs1149700; rs10999022; rs10762312; rs11596674; rs2763338; rs10999047; rs4746006; rs10999042; rs12766101; rs2704485; rs7905060; rs2683550; rs12357951; rs10762319; rs2894300; rs2704525; rs11598063; rs1149699; rs10998994; rs2894280; rs1227743; rs11596025; rs3897192; rs10998984; rs2683564; rs4746007; rs16927094; rs2274183; rs12777790; rs12146294; rs2395276; rs11597960; rs16926972; rs12243266; rs2763351; rs2642569; rs11596035; rs7914126; rs7920073; rs2683558; rs3858159; rs10823442; rs7903513; rs12258864; rs10998985; rs1227778; rs12249986; rs1227757; rs2763335; rs10999031; rs7903112; rs7088730; rs2683551; rs3998143; rs10999025; rs10999020; rs2683552; rs1227760; rs10999045; rs7088469; rs942580; rs4081173; rs11812487; rs12262462; rs2683559; rs7923425; rs10998986; rs4746011; rs2704500; rs10823434; rs2004075; rs2683570; rs3858152; rs2704496; rs10823441; rs12360410; rs4746923; rs10999055; rs10762313; rs4746916; rs1149698; rs10999034; rs10998999; rs7903773; rs12219391; rs7903479; rs10998980; rs12241271; rs10999033; rs17582395; rs7100823; rs11592257; rs10762316; rs2683554; rs10999026; rs3864815; rs10999013; rs10999049; rs2763364; rs10999054; rs1227755; rs11812091; rs16926931; rs2004076; rs4746915; rs1227783; rs2763361; rs1149695; rs3858151; rs2704497; rs942563; rs12780907; rs4237324; rs12259054; rs12357700; rs3858158; rs16926891; rs12765629; rs2704524; rs3793813; rs10999014; rs12247348; rs11595815; rs11592238; rs7903744; rs11598413; rs1227736; rs1227767; rs2274178; rs12570774; rs17500242; rs10762315; rs2704482; rs4117549; rs1149696; rs10999053; rs2395284; rs723332; rs1227754; rs4237323; rs2704502; rs10998982; rs7101050; rs4746928; rs12220889; rs12241163; rs7913732; rs2763348; rs3104051; rs2704506; rs2247427; rs2642608; rs2642607; rs9645503; rs2642606; rs3108965; rs41277962; rs1139025; rs10998973; rs1061957; rs3087817; rs41277950; rs41277948; rs34156339; rs10998989; rs1149693; rs3793820; rs12220176; rs34722561; rs35247685; rs10999036; rs10999007; rs1227740; rs12247845; rs10666724; rs7079209; rs34815557; rs33996062; rs1227781; rs35821277; rs5785950; rs7076030; rs12246125; rs10532425; rs11595845; rs3041545; rs35268667; rs34956979; rs34622590; rs10999030; rs34103212; rs35039949; rs36077539; rs12769085; rs41277958; rs2395285; rs10998978; rs10579532; rs12771833; rs10579533; rs2683574; rs34122139; rs36113573; rs34654543; rs35433604; rs10999008; rs2763354; rs1227741; rs35824626; rs7913904; rs34208853; rs2395273; rs35281572; rs35155651; rs5785959; rs35059034; rs5785961; rs11591925; rs7077888; rs35576341; rs12766652; rs12571349; rs34631476; rs35599858; rs2704458; rs1227774; rs2704518; rs5785953; rs10570834; rs34209097; rs35712679; rs35008644; rs11435683; rs10998977; rs4639832; rs34035700; rs12220381; rs34052059; rs12780431; rs3897194; rs12570480; rs35826556; rs11595846; rs35356623; rs35541600; rs10999041; rs35498309; rs1227742; rs10999001; rs7077117; rs12248301; rs11269485; rs3847352; rs34679757; rs28612175; rs35814096; rs1227749; rs35481329; rs3793817; rs35855071; rs34511383; rs5785958; rs11393895; rs35432411; rs28655106; rs2704493; rs41304639; rs11440912; rs35335058; rs5785952; rs10999010; rs35890813; rs35375802; rs3215785; rs10466016; rs10532424; rs36027972; rs35050048; rs12572883; rs41277954; rs34777479; rs34430582; rs1227750; rs4076958; rs41277952; rs35202962; rs10999032; rs12763830; rs12358449; rs34364532; rs10711936; rs10999040; rs7080232; rs12358784; rs7907037; rs4491117; rs36061242; rs34608233; rs34723278; rs35115899; rs35331550; rs10999048; rs2642603; rs34507493; rs2704478; rs35189240; rs2395282; rs34115230; rs11594892; rs12770259; rs35040554; rs3793816; rs8181405; rs36101986; rs34798965; rs12772368; rs28759328; rs2395281; rs35686597; rs2704519; rs34485208; rs12146342; rs4746930; rs5785955; rs41314992; rs3838764; rs12220750; rs2395277; rs34036046; rs11342895; rs2894307; rs35303964; rs36075969; rs28402903; rs7097639; rs35383805; rs12781264; rs35082769; rs11598529; rs7091586; rs10998974; rs1234472; rs10999012; rs2395283; rs35156591; rs12248138; rs35571506; rs12246325; rs34451560; rs2985538; rs3041529; rs12572895; rs2894306; rs12769079; rs34272832; rs35397368; rs12781498; rs33989837; rs35319109; rs7476322; rs11427754; rs2763347; rs10998991; rs35255453; rs4746931; rs34617852; rs12571404; rs12357718; rs3858162; rs34716964; rs34323794; rs35783107; rs5785954; rs1238303; rs2395274; rs7893249; rs35532046; rs10998987; rs10998975; rs36061268; rs12768311; rs36002361; rs41277956; rs2704501; rs35079330; rs5785957; rs34931480; rs2763344; rs34635918; rs1227745; rs35689681; rs7093397; rs34507144; rs35074119; rs35640837; rs2394575; rs10999005; rs35667296; rs4746932; rs2985536; rs11817414; rs2244334; rs34896629; rs35354997; rs16927101; rs12248233; rs3838765; rs35172574; rs10998981; rs12357568; rs1227782; rs10999023; rs41277960; rs7091467; rs2642604; rs35668760; rs2683566; rs5785951; rs12571118; rs10999003; rs35925377; rs3998817; rs12251591; rs4746914; rs35958074; rs11816285; rs36044059; rs34642672; rs5785956; rs12258326; rs4351722; rs10577959; rs35181086; rs2894308; rs10999006; rs34836797; rs12146343; rs9645504; rs2642605; rs10740324; rs10823432; rs10998968; rs10998970; rs10998971; rs10998972; rs1149690; rs1149691; rs11599159; rs11813182; rs11816910; rs12255270; rs1227761; rs12360465; rs12411657; rs12416673; rs16926886; rs17496974; rs2471725; rs2642609; rs2704507; rs2704509; rs2704510; rs2894090; rs3104052; rs3104053; rs3108966; rs35606080; rs3847354; rs3847355; rs3858163; rs3858164; rs3858165; rs3858166; rs4394723; rs4406710; rs4494212; rs4746004; rs768504; rs768505; rs7899029

# Macromolecular_Interacting_Partner_11_General_References:
1698771; 3547403; 2459707

# Macromolecular_Interacting_Partner_11_References:
16873415; 17053161

# Macromolecular_Interacting_Partner_12_ID:
7854

# Macromolecular_Interacting_Partner_12_Name:
Equilibrative nucleoside transporter 1

# Macromolecular_Interacting_Partner_12_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1

# Macromolecular_Interacting_Partner_12_Gene_Name:
SLC29A1

# Macromolecular_Interacting_Partner_12_Protein_Sequence:
>Equilibrative nucleoside transporter 1
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV

# Macromolecular_Interacting_Partner_12_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_12_Molecular_Weight:
50220

# Macromolecular_Interacting_Partner_12_Theoretical_pI:
8.39

# Macromolecular_Interacting_Partner_12_GO_Classification:
>>>
Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_12_General_Function:
Not Available

# Macromolecular_Interacting_Partner_12_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs)

# Macromolecular_Interacting_Partner_12_Pathway:
Not Available

# Macromolecular_Interacting_Partner_12_Reaction:
Not Available

# Macromolecular_Interacting_Partner_12_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_12_Signals:
1-24

# Macromolecular_Interacting_Partner_12_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_12_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_12_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_12_GenBank_ID_Protein:
1845345

# Macromolecular_Interacting_Partner_12_SwissProt_ID:
S29A1_HUMAN (Q99808)

# Macromolecular_Interacting_Partner_12_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_12_Genecard_id:
SLC29A1

# Macromolecular_Interacting_Partner_12_Geneatlas_id:
SLC29A1

# Macromolecular_Interacting_Partner_12_hgnc_id:
HGNC:11003

# Macromolecular_Interacting_Partner_12_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_12_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_12_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_12_Gene_Sequence:
>1371 bp
ATGACAACCAGTCACCAGCCTCAGGACAGATACAAAGCTGTCTGGCTTATCTTCTTCATG
CTGGGTCTGGGAACGCTGCTCCCGTGGAATTTTTTCATGACGGCCACTCAGTATTTCACA
AACCGCCTGGACATGTCCCAGAATGTGTCCTTGGTCACTGCTGAACTGAGCAAGGACGCC
CAGGCGTCAGCCGCCCCTGCAGCACCCTTGCCTGAGCGGAACTCTCTCAGTGCCATCTTC
AACAATGTCATGACCCTATGTGCCATGCTGCCCCTGCTGTTATTCACCTACCTCAACTCC
TTCCTGCATCAGAGGATCCCCCAGTCCGTACGGATCCTGGGCAGCCTGGTGGCCATCCTG
CTGGTGTTTCTGATCACTGCCATCCTGGTGAAGGTGCAGCTGGATGCTCTGCCCTTCTTT
GTCATCACCATGATCAAGATCGTGCTCATTAATTCATTTGGTGCCATCCTGCAGGGCAGC
CTGTTTGGTCTGGCTGGCCTTCTGCCTGCCAGCTACACGGCCCCCATCATGAGTGGCCAG
GGCCTAGCAGGCTTCTTTGCCTCCGTGGCCATGATCTGCGCTATTGCCAGTGGCTCGGAA
CTATCAGAAAGTGCCTTCGGCTACTTTATCACAGCCTGTGCTGTTATCATTTTGACCATC
ATCTGTTACCTGGGCCTGCCCCGCCTGGAATTCTACCGCTACTACCAGCAGCTCAAGCTT
GAAGGACCCGGGGAGCAGGAGACCAAGTTGGACCTCATTAGCAAAGGAGAGGAGCCAAGA
GCAGGCAAAGAGGAATCTGGAGTTTCAGTCTCCAACTCTCAGCCCACCAATGAAAGCCAC
TCTATCAAAGCCATCCTGAAAAATATCTCAGTCCTGGCTTTCTCTGTCTGCTTCATCTTC
ACTATCACCATTGGGATGTTTCCAGCCGTGACTGTTGAGGTCAAGTCCAGCATCGCAGGC
AGCAGCACCTGGGAACGTTACTTCATTCCTGTGTCCTGTTTCTTGACTTTCAATATCTTT
GACTGGTTGGGCCGGAGCCTCACAGCTGTATTCATGTGGCCTGGGAAGGACAGCCGCTGG
CTGCCAAGCCTGGTGCTGGCCCGGCTGGTGTTTGTGCCACTGCTGCTGCTGTGCAACATT
AAGCCCCGCCGCTACCTGACTGTGGTCTTCGAGCACGATGCCTGGTTCATCTTCTTCATG
GCTGCCTTTGCCTTCTCCAACGGCTACCTCGCCAGCCTCTGCATGTGCTTCGGGCCCAAG
AAAGTGAAGCCAGCTGAGGCAGAGACCGCAGGAGCCATCATGGCCTTCTTCCTGTGTCTG
GGTCTGGCACTGGGGGCTGTTTTCTCCTTCCTGTTCCGGGCAATTGTGTGA

# Macromolecular_Interacting_Partner_12_GenBank_ID_Gene:
U81375

# Macromolecular_Interacting_Partner_12_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_12_Locus:
6p21.2-p21.1

# Macromolecular_Interacting_Partner_12_SNPs:
Not Available

# Macromolecular_Interacting_Partner_12_General_References:
8986748; 10755314; 12384580

# Macromolecular_Interacting_Partner_12_References:
16688763; 16824629

# Macromolecular_Interacting_Partner_13_ID:
8758

# Macromolecular_Interacting_Partner_13_Name:
Equilibrative nucleoside transporter 2

# Macromolecular_Interacting_Partner_13_Synonyms:
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; 36 kDa nucleolar protein HNP36; Hydrophobic nucleolar protein, 36 kDa; Delayed-early response protein 12

# Macromolecular_Interacting_Partner_13_Gene_Name:
SLC29A2

# Macromolecular_Interacting_Partner_13_Protein_Sequence:
>Equilibrative nucleoside transporter 2
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTG
PEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVD
MSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLL
SMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAE
LLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLV
FTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRL
LPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPR
QVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL

# Macromolecular_Interacting_Partner_13_Number_of_Residues:
456

# Macromolecular_Interacting_Partner_13_Molecular_Weight:
50114

# Macromolecular_Interacting_Partner_13_Theoretical_pI:
6.02

# Macromolecular_Interacting_Partner_13_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_13_General_Function:
Not Available

# Macromolecular_Interacting_Partner_13_Specific_Function:
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine

# Macromolecular_Interacting_Partner_13_Pathway:
Not Available

# Macromolecular_Interacting_Partner_13_Reaction:
Not Available

# Macromolecular_Interacting_Partner_13_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_13_Signals:
1-24

# Macromolecular_Interacting_Partner_13_Transmembrane_Regions:
13-33
70-90
99-119
124-144
162-182
193-213
291-311
324-344
360-380
386-406
432-452

# Macromolecular_Interacting_Partner_13_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_13_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_13_GenBank_ID_Protein:
2811137

# Macromolecular_Interacting_Partner_13_SwissProt_ID:
S29A2_HUMAN (Q14542)

# Macromolecular_Interacting_Partner_13_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_13_Genecard_id:
SLC29A2

# Macromolecular_Interacting_Partner_13_Geneatlas_id:
SLC29A2

# Macromolecular_Interacting_Partner_13_hgnc_id:
HGNC:11004

# Macromolecular_Interacting_Partner_13_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_13_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_13_Subcellular_Location:
Isoform 1:Cell membrane; multi-pass membrane protein. Isoform 2:Nucleus; nuclear membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_13_Gene_Sequence:
>1371 bp
ATGGCGCGAGGAGACGCCCCGCGGGACAGCTACCACCTGGTCGGGATCAGCTTCTTCATC
CTGGGGCTGGGCACCCTCCTTCCCTGGAACTTCTTCATCACCGCCATCCCGTACTTCCAG
GCGCGACTGGCCGGGGCCGGCAACAGCACAGCCAGGATCCTGAGCACCAACCACACGGGT
CCCGAGGATGCCTTCAACTTCAACAATTGGGTGACGCTGCTGTCCCAGCTGCCCCTGCTG
CTCTTCACCCTCCTCAACTCCTTCCTGTACCAGTGCGTCCCGGAGACGGTGCGCATTCTG
GGCAGCCTGCTGGCCATACTGCTGCTCTTTGCCCTGACAGCAGCGCTGGTCAAGGTGGAC
ATGAGCCCCGGACCCTTCTTCTCCATCACCATGGCCTCCGTCTGCTTCATCAACTCCTTC
AGTGCAGTCCTACAGGGCAGCCTCTTCGGGCAGCTGGGCACCATGCCCTCCACCTACAGC
ACCCTCTTCCTCAGCGGCCAGGGCCTGGCTGGGATCTTTGCTGCCCTTGCCATGCTCCTG
TCCATGGCCAGTGGCGTGGACGCCGAGACCTCTGCCCTGGGGTACTTTATCACGCCCTGT
GTGGGCATCCTCATGTCCATCGTGTGTTACCTGAGCCTGCCTCACCTGAAGTTTGCCCGC
TACTACCTGGCCAATAAATCATCCCAGGCCCAAGCTCAGGAGCTGGAGACCAAAGCTGAG
CTCCTCCAGTCTGATGAGAACGGGATTCCCAGTAGTCCCCAGAAAGTAGCTCTGACCCTG
GATCTTGACCTGGAGAAGGAGCCGGAATCAGAGCCAGATGAGCCCCAGAAGCCAGGAAAA
CCTTCAGTCTTCACTGTCTTCCAGAAGATCTGGCTGACAGCGCTGTGCCTTGTGTTGGTC
TTCACAGTCACCCTGTCCGTCTTCCCCGCCATCACAGCCATGGTGACCAGCTCCACCAGT
CCTGGGAAGTGGAGTCAGTTCTTCAACCCCATCTGCTGCTTCCTCCTCTTCAACATCATG
GACTGGCTGGGACGGAGCCTGACCTCTTACTTCCTGTGGCCAGACGAGGACAGCCGGCTG
CTGCCCCTGCTGGTCTGCCTGCGGTTCCTGTTCGTGCCCCTCTTCATGCTGTGCCACGTG
CCCCAGAGGTCCCGGCTGCCCATCCTCTTCCCACAGGATGCCTACTTCATCACCTTCATG
CTGCTCTTTGCCGTTTCTAATGGCTACCTGGTGTCCCTCACCATGTGCCTGGCGCCCAGG
CAGGTGCTGCCACACGAGAGGGAGGTGGCCGGCGCCCTCATGACCTTCTTCCTGGCCCTG
GGACTTTCCTGTGGAGCCTCCCTCTCCTTCCTCTTCAAGGCGCTGCTCTGA

# Macromolecular_Interacting_Partner_13_GenBank_ID_Gene:
AF034102

# Macromolecular_Interacting_Partner_13_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_13_Locus:
11q13

# Macromolecular_Interacting_Partner_13_SNPs:
rs8187661; rs1039593; rs3177514; rs4930358; rs7126064; rs2292123; rs2279861; rs2279862; rs7125100; rs7126018; rs12416747; rs1039594; rs10791872; rs8187658; rs3867130; rs12576299; rs1344410; rs12576293; rs12577196; rs4930178; rs4930359; rs12281049; rs4244813; rs7107191; rs7104297; rs17850744; rs17855425; rs12801227; rs34186490; rs34124904; rs11227466; rs4554890; rs3741366; rs10605893; rs11403442; rs7111197; rs10632640; rs35639157; rs35962792; rs7946434; rs33943132; rs34029417; rs1815807; rs35659701; rs7103571; rs35791794; rs10648232; rs11423263; rs34482391; rs1566871; rs11298226; rs12800796; rs35509820; rs11461356; rs35457397; rs1201452; rs1210071; rs34585457; rs12360603; rs1047029; rs10791871; rs12794121; rs34272485; rs7130857; rs8187644; rs8187646; rs8187647; rs8187657; rs8187659; rs8187660

# Macromolecular_Interacting_Partner_13_General_References:
9478986; 9396714; 7639753

# Macromolecular_Interacting_Partner_13_References:
Not Available

# Macromolecular_Interacting_Partner_14_ID:
8857

# Macromolecular_Interacting_Partner_14_Name:
Equilibrative nucleoside transporter 3

# Macromolecular_Interacting_Partner_14_Synonyms:
Solute carrier family 29 member 3

# Macromolecular_Interacting_Partner_14_Gene_Name:
SLC29A3

# Macromolecular_Interacting_Partner_14_Protein_Sequence:
>Equilibrative nucleoside transporter 3
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTFSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATIF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAVCTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI

# Macromolecular_Interacting_Partner_14_Number_of_Residues:
475

# Macromolecular_Interacting_Partner_14_Molecular_Weight:
51875

# Macromolecular_Interacting_Partner_14_Theoretical_pI:
7.85

# Macromolecular_Interacting_Partner_14_GO_Classification:
>>>
 Function:  transporter activity
Function:  nucleobase, nucleoside, nucleotide and nucleic acid transporter activity
Function:  nucleoside transporter activity
 ||
>>>
 Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
 Component:  cell
Component:  membrane

# Macromolecular_Interacting_Partner_14_General_Function:
Not Available

# Macromolecular_Interacting_Partner_14_Specific_Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter)

# Macromolecular_Interacting_Partner_14_Pathway:
Not Available

# Macromolecular_Interacting_Partner_14_Reaction:
Not Available

# Macromolecular_Interacting_Partner_14_Pfam_Domain_Function:
PF01733:Nucleoside_tran

# Macromolecular_Interacting_Partner_14_Signals:
Not Available

# Macromolecular_Interacting_Partner_14_Transmembrane_Regions:
50-72
107-126
131-153
163-185
198-220
230-252
308-330
340-357
378-395
415-437
450-472

# Macromolecular_Interacting_Partner_14_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_14_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_14_GenBank_ID_Protein:
12656639

# Macromolecular_Interacting_Partner_14_SwissProt_ID:
S29A3_HUMAN (Q9BZD2)

# Macromolecular_Interacting_Partner_14_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_14_Genecard_id:
SLC29A3

# Macromolecular_Interacting_Partner_14_Geneatlas_id:
SLC29A3

# Macromolecular_Interacting_Partner_14_hgnc_id:
HGNC:23096

# Macromolecular_Interacting_Partner_14_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_14_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_14_Subcellular_Location:
Membrane; multi-pass membrane protein

# Macromolecular_Interacting_Partner_14_Gene_Sequence:
>1428 bp
ATGGCCGTTGTCTCAGAGGACGACTTTCAGCACAGTTCAAACTCCACCTACAGAACCACA
AGCAGCAGTCTCCGAGCTGACCAGGAGGCACTGCTTGAGAAGCTGCTGGACCGCCCGCCC
CCTGGCCTGCAGAGGCCCGAGGACCGCTTCTGTGGCACATACATCATCTTCTTCAGCCTG
GGCATTGGCAGTCTACTGCCATGGAACTTCTTTATCACTGCCAAGGAGTACTGGATGTTC
AAACTCCGCAACTCCTCCAGCCCAGCCACCGGGGAGGACCCTGAGGGCTCAGACATCCTG
AACTACTTTGAGAGCTACCTTGCCGTTGCCTCCACCGTGCCCTCCATGCTGTGCCTGGTG
GCCAACTTCCTGCTTGTCAACAGGGTTGCAGTCCACATCCGTGTCCTGGCCTCACTGACG
GTCATCCTGGCCATCTTCATGGTGATAACTGCACTGGTGAAGGTGGACACTTTCTCCTGG
ACCCGTGGCTTTTTTGCGGTCACCATTGTCTGCATGGTGATCCTCAGCGGTGCCTCCACT
GTCTTCAGCAGCAGCATCTACGGCATGACCGGCTCCTTTCCTATGAGGAACTCCCAGGCA
CTGATATCAGGAGGAGCCATGGGCGGGACGGTCAGCGCCGTGGCCTCATTGGTGGACTTG
GCTGCATCCAGTGATGTGAGGAACAGCGCCCTGGCCTTCTTCCTGACGGCCACCATCTTC
CTCGTGCTCTGCATGGGACTCTACCTGCTGCTGTCCAGGCTGGAGTATGCCAGGTACTAC
ATGAGGCCTGTTCTTGCGGCCCATGTGTTTTCTGGTGAAGAGGAGCTTCCCCAGGACTCC
CTCAGTGCCCCTTCGGTGGCCTCCAGATTCATTGATTCCCACACACCCCCTCTCCGCCCC
ATCCTGAAGAAGACGGCCAGCCTGGGCTTCTGTGTCACCTACGTCTTCTTCATCACCAGC
CTCATCTACCCCGCCGTCTGCACCAACATCGAGTCCCTCAACAAGGGCTCGGGCTCACTG
TGGACCACCAAGTTTTTCATCCCCCTCACTACCTTCCTCCTGTACAACTTTGCTGACCTA
TGTGGCCGGCAGCTCACCGCCTGGATCCAGGTGCCAGGGCCCAATAGCAAGGCGCTCCCA
GGGTTCGTGCTCCTCCGGACCTGCCTCATCCCCCTCTTCGTGCTCTGTAACTACCAGCCC
CGCGTCCACCTGAAGACTGTGGTCTTCCAGTCCGATGTGTACCCCGCACTCCTCAGCTCC
CTGCTGGGGCTCAGCAACGGCTACCTCAGCACCCTGGCCCTCCTCTACGGGCCTAAGATT
GTGCCCAGGGAGCTGGCTGAGGCCACGGGAGTGGTGATGTCCTTTTATGTGTGCTTGGGC
TTAACACTGGGCTCAGCCTGCTCTACCCTCCTGGTGCACCTCATCTAG

# Macromolecular_Interacting_Partner_14_GenBank_ID_Gene:
AF326987

# Macromolecular_Interacting_Partner_14_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_14_Locus:
10q22.1

# Macromolecular_Interacting_Partner_14_SNPs:
rs2487068; rs2252996; rs780668; rs2277257; rs999940; rs16928737; rs2252997; rs1084004; rs2275579; rs780680; rs780664; rs1538899; rs780660; rs780659; rs780666; rs703257; rs780654; rs946875; rs703256; rs2394793; rs7069807; rs1110399; rs780677; rs4600131; rs780675; rs2243460; rs780670; rs780676; rs6480510; rs2487067; rs6480511; rs809691; rs883764; rs7086724; rs12256138; rs2012500; rs780662; rs4494244; rs780672; rs780653; rs3781314; rs2249987; rs1538895; rs2066211; rs780655; rs10823723; rs1316421; rs11815656; rs3824770; rs7100381; rs2250002; rs6480513; rs12251921; rs12767108; rs16928705; rs10999773; rs10999778; rs1572810; rs7076329; rs6480514; rs780667; rs7090745; rs2249882; rs883763; rs780679; rs780674; rs7080325; rs3781316; rs2249989; rs780678; rs11812689; rs780669; rs2487066; rs2243496; rs7067629; rs10999776; rs7095417; rs11594628; rs780665; rs4430425; rs4348816; rs780661; rs3781311; rs3781313; rs2249753; rs10999770; rs7091983; rs884031; rs3781324; rs780658; rs10999775; rs7072838; rs780671; rs946973; rs10740374; rs12252326; rs3781310; rs10999771; rs3781309; rs3781312; rs1890885; rs2243540; rs3758570; rs3781317; rs2066209; rs780656; rs7900534; rs7083031; rs2066210; rs6480512; rs12220541; rs884681; rs3781327; rs16928722; rs7068179; rs7090777; rs12249513; rs10740375; rs7913673; rs780673; rs10999777; rs10999781; rs780657; rs7090611; rs884680; rs3781326; rs7086520; rs7071162; rs7071738; rs2249752; rs12252139; rs17525188; rs12252279; rs2243485; rs7071979; rs10999772; rs3781325; rs7087714; rs7084342; rs4747148; rs7924115; rs946979; rs780681; rs1572812; rs35065420; rs6650127; rs34069552; rs10716665; rs35206666; rs12263170; rs10625840; rs34905233; rs11376986; rs35919163; rs5786035; rs34110374; rs12356731; rs35335105; rs12269478; rs12243734; rs34152212; rs7913062; rs3059614; rs12762394; rs7911708; rs7914132; rs4746081; rs7094989; rs35701283; rs12267767; rs12220170; rs7068296; rs34294547; rs35368644; rs41281300; rs3781318; rs4641383; rs7916422; rs34315182; rs10999774; rs35720104; rs10999769; rs35239123; rs7077024; rs3837344; rs7913610; rs10552605; rs10999779; rs780663; rs35509882; rs3893272; rs3059612; rs35156362; rs1609652; rs35485497; rs34058912; rs12243650; rs4147262; rs7903407; rs35942216; rs12763826; rs3837345; rs34297699; rs34965758; rs3824768; rs34491538; rs41300554; rs36074226; rs7095479; rs7067937; rs11296364; rs35855172; rs7897272; rs34640546; rs3781315; rs34395748; rs12355187; rs12261581; rs10686987; rs12779065; rs10999783; rs36087675; rs12762772; rs5786034; rs10999782; rs34650529; rs34632350; rs10553895; rs34721394; rs12249991; rs11593088; rs3059610; rs28708771; rs35956296; rs10999768; rs28688626; rs35685893; rs10823722; rs10999766; rs10999784; rs10999785; rs10999786; rs10999788; rs11595617; rs11816935; rs12098507; rs12254223; rs12412201; rs12414898; rs1538898; rs1609651; rs17546494; rs2185416; rs2248674; rs34217506; rs35016944; rs35685474; rs7079524; rs780682; rs780683; rs780687; rs780688; rs780689; rs780690; rs780692; rs780693; rs780694; rs780695; rs780697; rs780698; rs7895122; rs7899555; rs869545; rs946879

# Macromolecular_Interacting_Partner_14_General_References:
11396612; 12384580; 12975309

# Macromolecular_Interacting_Partner_14_References:
Not Available

End of HMDB00050

Beginning of HMDB00051
# Accession_No:
HMDB00051

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:25:35

# biospider_lastupdate:
2007-07-25 09:17:15

# Common_Name:
Ammonia

# Description:
Ammonia is a colorless alkaline gas with a characteristic pungent smell; it is lighter than air, (density =0.589). It is easily liquefied and the liquid boils at -33.7 degree centigrade , and solidifies at -75 degree  centigrade to a mass of white crystals.  Ammonia is an important source of nitrogen for living systems.  Ammonia is formed in the body during decomposition of organic materials during a large number of metabolically important reactions.  Ammonia also plays a role in both normal and abnormal animal physiology. Ammonia is created through normal amino acid metabolism and is toxic in high concentrations. The liver converts ammonia to urea through a series of reactions known as the urea cycle. Liver dysfunction, such as that seen in cirrhosis, may lead to elevated amounts of ammonia in the blood (hyperammonemia).

# Synonyms:
Amine; Ammoniaca [italian]; Am-fol; Tertiaeres amin; Amino group; Tertiary amine; Liquid ammonia; Nitro-sil; Amoniak [polish]; NA; Terminal amide; NH; Nitrogen radical; Ammonia inhalant; Ammoniak [german]; Ammonia solution strong (NF); Ammonia gas; Ammonium bromide-81Br; Anhydrous ammonia;  Primary amines; Ammonia anhydrous; Ammonia (conc 20% or greater); Aromatic ammonia vaporole; Ammoniacum gummi; Primaeres amin; Ammonium ion; Sekundaeres amin; Secondary amines;  Ammoniak; Ammoniakgas; E Remark 999; Primary amine; Nitrogen atom; Ammonia solution; R-NH2; Primary monoamine; Ammonia water; Azane; Secondary amine; Ammonia solution strong [usan]; Spirit of hartshorn; Ammonia water (JP15); Ammoniac [french]; Ammoniak kconzentrierter; R2NH; Ammonia

# Chemical_IUPAC_Name:
ammonia

# Chemical_Formula:
NH3

# Chemical_Structure:
tbl_chemical:::HMDB00051_ZOOM.png:::119283156339788613

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00051_THUMB.png:::119283156166962311

# Taxonomy_Kingdom:
Inorganic

# Taxonomy_Class:
Nitrogenous Compounds

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
Not Available

# Taxonomy_Biofunction:
Component of Alanine and aspartate metabolism; Component of Aminosugars metabolism; Component of Arginine and proline metabolism; Component of beta-Alanine metabolism; Component of Cysteine metabolism; Component of D-Arginine and D-ornithine metabolism; Component of D-Glutamine and D-glutamate metabolism; Component of Glutamate metabolism; Component of Glycine, serine and threonine metabolism; Component of Histidine metabolism; Component of Methionine metabolism; Component of Nitrogen metabolism; Component of Peptidoglycan biosynthesis; Component of Phenylalanine metabolism; Component of Purine metabolism; Component of Pyrimidine metabolism; Component of Selenoamino acid metabolism; Component of Tryptophan metabolism; Component of Tyrosine metabolism; Component of Vitamin B6 metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
17.02655

# Molecular_Weight_Avg:
17.03052

# Smiles_String_isomeric:
N

# Smiles_String_canonical:
N

# KEGG_Compound_ID:
C00014

# BioCyc_ID:
AMMONIA

# PubChem_CID:
222

# PubChem_SID:
8014513; 594654; 24857750; 24873257; 8029108; 17422787; 10535283; 10317926; 17422543; 11538887; 24868666; 8012124; 17436446; 8017037; 8029533; 8020772; 8011146; 8010373; 24865474; 8027842; 3316; 8007867; 8007223; 8009405; 8028893; 8026010; 8026008; 8024133; 8018273; 10317931; 5257791; 8013167; 22394623; 8019657; 8020837; 8007773; 8026161; 14710328; 8150513; 8007244; 166832; 17397073; 8006866; 8021081; 24860942; 8028993; 8027841; 10323059; 8017829; 8029098; 23944516; 8007154; 8012764; 8021613; 8022912; 8010125; 14716551; 8017842; 24875167; 24902263; 24770310; 8029099; 8145302; 8007587; 8021080; 8145696; 15119548; 10318863; 8021176; 10318864; 14716925; 8011144; 8011141; 8010494; 8007247; 24770816; 8007249; 8021173; 10317925; 24770315; 24864477; 8017435; 8009335; 8013207; 24697563; 10511053; 17403736; 8019079; 8023899; 8026465; 24864476; 8029392; 8007409; 10317924; 10317928; 8013400; 8028825; 8007239; 8027987; 22394625; 8008747

# OMIM_ID:
102770; 237310; 238700; 238970

# Metagene_ID:
CARNITINE TRANSPORTER DEFECT. PRIMARY SYSTEMIC CARNITINE DEFICIENCY: 90; PATENT DUCTUS VENOSUS: 460; VALPROATE THERAPY: ANTICONVULASANT HYPERSENSITIVITY SYNDROME VALPROATE ASSOCIATED HEPATOTOXICITY: 324; PROPIONIC ACIDEMIA. KETOTIC HYPERGLYCINEMIA (PA): 18; 3-METHYLGLUTACONIC ACIDURIA (TYPE IV): 338; LIVER DISEASE, LIVER FAILURE, UNSPECIFIC: 264; ARGININOSUCCINIC ACIDURIA (ASL): 25; 3-METHYL-CROTONYL-GLYCINURIA: 27; PYRUVATE DEHYDROGENASE DEFICIENCY (E3): 333; SHORT CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD): 40; HYPERDIBASIC AMINOACIDURIA II. LYSINURIC PROTEIN INTOLERANCE: 61; METHYLMALONIC ACIDURIA, cblB TYPE: 517; REYE SYNDROME LIKE MANIFESTATIONS: 303; REYE SYNDROME: 268; CITRULLINEMIA TYPE I. ASS: 92; N-ACETYLGLUTAMATE SYNTHETASE DEFICIENCY. NAGS DEFICIENCY: 243; PYRUVATE CARBOXYLASE DEFICIENCY: 109; LONG-CHAIN-3-HYDROXYACYL-CoA DEHYDROGENASE DEFICIENCY (LCHAD): 308; HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]: 215; ISOVALERIC ACIDEMIA: 10; FUMARIC ACIDURIA: 31; ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC): 189; METHYLMALONIC ACIDURIA, cblA TYPE: 328; CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY: 342; CARNITINE DEFICIENCY, MYOPATHIC: 282; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (I): 263; MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM: 79; CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY (CPS): 77; DELTA-PYRROLIDINE-5-CARBOXYLATE SYNTHASE DEFICIENCY: 474; MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD): 39; CARNITINE PALMITOYL TRANSFERASE DEFICIENCY (II): 94; GLUTARIC ACIDURIA II: 9; METHYLMALONIC ACIDURIA (MMA): 15; CITRULLINEMIA TYPE II, ADULT-ONSET: 448; ARGININEMIA. HYPERARGININEMIA, ARGINASE DEFICIENCY: 60; 3-HYDROXY-3-METHYLGLUTARYL-CoA LYASE DEFICIENCY: 4; PYRUVATE DEHYDROGENASE DEFICIENCY (E2): 431; BIOTINIDASE DEFICIENCY: 73; ACRODERMATITIS ENTEROHEPATHICA: 411; HYPERINSULINISM-HYPERAMMONEMIA SYNDROME: 459; GLUTATHIONE SYNTHETASE DEFICIENCY: 19; BETA-KETOTHIOLASE DEFICIENCY: 5

# BiGG_ID:
Not Available

# Wikipedia_ID:
Ammonia

# METLIN_ID:
3189

# Ref_ID:
11779097; 10327416; 12445521; 12881593; 8579834; 11754523; 11842946; 15783019; 15611036; 10803116; 11388600; 12020613; 15058165; 10958815; 12553956; 10587497; 15005636; 10370701; 10356662; 10395620

# ChEBI_ID:
16134

# CAS_Registry_Number:
7664-41-7

# InChI:
InChI=1/H3N/h1H3

# Synthesis_Reference:
Not Available

# Melting_Point:
-77.7 oC

# Melting_Point_predicted:
13.1 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
482 mg/mL at 24 oC [DEAN,JA (1985)]

# H2O_Solubility_Predicted:
Not Available

# phys_charge:
0

# State:
Liquid

# LogP:
Not Available

# LogP_predicted:
0.23 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::HMDB00051.pdf:::118537663644941172

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Ammonia.mol:::1132723803656136971

# SDF_File_[Text]:
tbl_chemical:::HMDB00051.sdf:::11928315590284364

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00051.pdb:::119283156033355981

# PDB_ID:
1D2U

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
tbl_chemical:::1D2U.txt:::1132720900312495045

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Ammonia.gif:::1132732102796550646

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00051_peaks.txt:::1156309511137847597

# Predicted_C_NMR_Spectrum:
Not Available

# pred_cnmr_peaklist:
Not Available

# Mass_Spectrum:
tbl_chemical:::HMDB00051.jpg:::1132798875875697869

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
All Tissues

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Cellular Cytoplasm; Feces; Saliva; Sweat; Urine

# Concentration_[Normal]:
Urine	1900.0 +/- 350.0	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	11842946
Urine	2330.0 (724.0-3950.0)	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Doctor's Data
Blood	27.5 +/- 3.6	N/A	Adult:>18_yrs_old	Both	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basel, Switzerland c1981-1992.
Blood	29.0 (10.0-47.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	29.0 (13.0 - 46.0)	umol/L	Adult:>18_yrs_old	N/A	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	35.0 (20.0 - 58.0)	umol/L	Adult:>18_yrs_old	Male	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	29.0 (17.0 - 51.0)	umol/L	Adult:>18_yrs_old	Female	Normal	Geigy Scientific Tables, 8th Rev edition, pp. 91. Edited by Cornelius Lentner.; West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp.; Basle, Switzerland c1981-1992.
Blood	50.4 +/- 17.0	uM	Adult:>18_yrs_old	Both	Normal	12553956
Cerebrospinal_Fluid(CSF)	11.9	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Cellular_Cytoplasm	800 (700-900)	umol/L	Adult:>18_yrs_old	Both	Normal	8579834


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
3-Hydroxy-3-Methylglutaric Acidemia; 3-Methyl-Crotonyl-Glycinuria; 3-Methylglutaconic Aciduria (Type IV); Acrodermatitis Enterohepathica; Adenosylcobalamin Deficiency (CBLA, CBLB); Anticonvulasant Hypersensitivity Syndrome Valproate Associated Hepatotoxicity (in valproate therapy); Argininemia, Hyperargininemia, Arginase Deficiency; Argininosuccinic Aciduria (ASL); Beta-Ketothiolase Deficiency; Biotinidase Deficiency; Carbamoyl Phosphate Synthetase Deficiency (CPS); Carnitine Deficiency, Myopathic; Carnitine Palmitoyl Transferase Deficiency (I); Carnitine Palmitoyl Transferase Deficiency (II); Carnitine-Acylcarnitine Translocase Deficiency; Citrullinemia Type I; Citrullinemia Type II, Adult-Onset; Delta-Pyrrolidine-5-Carboxylate Synthase Deficiency; Fumaric Aciduria; Gastritis; Glutaric Aciduria II; Glutathione Synthetase Deficiency; Hepatic Encephalopathy; Hyperdibasic Aminoaciduria II, Lysinuric Protein Intolerance; Hyperinsulinism-Hyperammonemia Syndrome; Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH-Syndrome); Hypopituitarism; Isovaleric Acidemia; Liver Disease, Liver Failure, Unspecific; Long-Chain-3-Hydroxyacyl-Coa Dehydrogenase Deficiency (LCHAD); Medium Chain Acyl-Coa Dehydrogenase Deficiency (MCAD); Methylmalonic Aciduria (MMA); Multiple Carboxylase Deficiency, Neonatal or Early Onset Form; N-Acetylglutamate Synthetase Deficiency (NAGS Deficiency); Ornithine Transcarbamylase Deficiency (OTC); Patent Ductus Venosus; Primary Systemic Carnitine Deficiency; Propionic Acidemia, Ketotic Hyperglycinemia (PA); Pyruvate Carboxylase Deficiency; Pyruvate Dehydrogenase Deficiency (E2); Pyruvate Dehydrogenase Deficiency (E3); Reye Syndrome; Reye Syndrome Like Manifestations; Short Chain Acyl-Coa Dehydrogenase Deficiency (SCAD)

# Pathway_Names:
Aminosugars metabolism;Type II secretion system;Purine metabolism;Vitamin B6 metabolism;Porphyrin and chlorophyll metabolism;Pantothenate and CoA biosynthesis;One carbon pool by folate;Glycolysis;Methionine metabolism;D-Arginine and D-ornithine metabolism;Alanine and aspartate metabolism

# Pathway_Images:
;Type II secretion system | map03090;Purine_Synthesis.jpg;;;;;Glycolysis.jpg;Methionine_Metabolism.jpg;;Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00530;;map00230;map00750;map00860;map00770;map00670;map00010;map00271;map00472;map00252

# Pathway_Graphs:
;;Purine_Synthesis_Graph.jpg;;;;;Glycolysis_Graph.jpg;Methionine_Metabolism_Graph.jpg;;Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
;;Purine_Synthesis.xml;;;;;Glycolysis.xml;Methionine_Metabolism.xml;;Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5443

# Metabolic_Enzyme_1_Name:
Glucosamine-6-phosphate isomerase

# Metabolic_Enzyme_1_Synonyms:
Glucosamine-6- phosphate deaminase; GNPDA; GlcN6P deaminase; Oscillin

# Metabolic_Enzyme_1_Gene_Name:
GNPDA1

# Metabolic_Enzyme_1_Protein_Sequence:
>Glucosamine6phosphate isomerase
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD

# Metabolic_Enzyme_1_Number_of_Residues:
289

# Metabolic_Enzyme_1_Molecular_Weight:
32669

# Metabolic_Enzyme_1_Theoretical_pI:
6.91

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, interconverting aldoses and ketoses
Function:  glucosamine-6-phosphate deaminase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  amine metabolism
Process:  amino sugar metabolism
Process:  glucosamine metabolism
Process:  N-acetylglucosamine metabolism
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  carbohydrate metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3)

# Metabolic_Enzyme_1_Pathway:
map00530  Aminosugars metabolism

# Metabolic_Enzyme_1_Reaction:
D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + ammonia

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF01182:Glucosamine_iso

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 3.5.99.6

# Metabolic_Enzyme_1_GenBank_ID_Protein:
2935438

# Metabolic_Enzyme_1_SwissProt_ID:
GNPI_HUMAN (P46926)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
GNPDA1

# Metabolic_Enzyme_1_Geneatlas_id:
GNPDA1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:4417

# Metabolic_Enzyme_1_PDB_ID:
1NE7

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>870 bp
ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC
AGGAACCGTATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC
ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC
CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC
CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC
CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC
TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT
GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG
ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG
GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG
ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG
AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC
GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT
GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC
CAATCTTCGAAGAAACCATACAGCGATTAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
AF048826

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_1_Locus:
5q21

# Metabolic_Enzyme_1_SNPs:
rs164080; rs7408; rs252120; rs2232193; rs252115; rs252111; rs252114; rs2232196; rs252112; rs1898679; rs252119; rs10214150; rs108593; rs351251; rs11746455; rs252118; rs252113; rs252117; rs7730740; rs252123; rs6887699; rs644639; rs252125; rs379285; rs252124; rs17524593; rs164501; rs644683; rs252122; rs428205; rs420547; rs11557800; rs2232198; rs1802147; rs1804084; rs2232192; rs11557799; rs4623179; rs35979770; rs449560; rs2232201; rs13175480; rs28672679; rs35914330; rs10628648; rs7708455; rs2232197; rs1134940; rs9986308; rs35408304; rs2232199; rs2232200; rs36114825; rs2232195; rs2232194; rs7733407; rs252094; rs189500; rs34467154; rs35952167; rs13187511; rs34537521; rs252116; rs41339846; rs3045628; rs35395011; rs426964; rs34709199; rs370150; rs12187204; rs11400936; rs6862017; rs6883498; rs13180040; rs164500; rs379553; rs33940540; rs12658433; rs10078983; rs153146; rs163920; rs164081; rs164498; rs164499; rs168331; rs252091; rs33992487; rs34476681; rs347525; rs366749; rs369592; rs379784; rs3910558; rs392582; rs403075; rs418921; rs439466; rs4912790; rs6580215; rs661944; rs665400

# Metabolic_Enzyme_1_General_References:
9438414; 7584044

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5802

# Metabolic_Enzyme_2_Name:
Cytidine deaminase

# Metabolic_Enzyme_2_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_2_Gene_Name:
CDA

# Metabolic_Enzyme_2_Protein_Sequence:
>Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
146

# Metabolic_Enzyme_2_Molecular_Weight:
16185

# Metabolic_Enzyme_2_Theoretical_pI:
6.95

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  cytidine deaminase activity
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleoside metabolism
Process:  pyrimidine nucleoside metabolism
Process:  pyrimidine ribonucleoside metabolism
Process:  cytidine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

# Metabolic_Enzyme_2_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_2_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_2_GenBank_ID_Protein:
598149

# Metabolic_Enzyme_2_SwissProt_ID:
CDD_HUMAN (P32320)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
CDA

# Metabolic_Enzyme_2_Geneatlas_id:
CDA

# Metabolic_Enzyme_2_hgnc_id:
HGNC:1712

# Metabolic_Enzyme_2_PDB_ID:
1MQ0

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_2_Gene_Sequence:
>441 bp
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
L27943

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p36.2-p35

# Metabolic_Enzyme_2_SNPs:
rs2072671; rs1048977; rs602950; rs1781459; rs818194; rs12402391; rs818199; rs818196; rs558946; rs580032; rs818207; rs1689924; rs10916824; rs3738130; rs527912; rs10799647; rs577042; rs10916829; rs12404655; rs818193; rs498617; rs1253920; rs572529; rs818192; rs818197; rs477155; rs589942; rs12036993; rs517483; rs10916828; rs818198; rs11579252; rs471760; rs2985316; rs7523472; rs4655226; rs6659399; rs10916825; rs7548190; rs11579101; rs12407778; rs7534998; rs11578210; rs1781461; rs12068596; rs12119998; rs11583986; rs7535303; rs10799648; rs7523547; rs10916826; rs563329; rs12406106; rs11580375; rs818200; rs12072405; rs12120002; rs7523557; rs11801036; rs588485; rs7535200; rs7513317; rs1253921; rs7537463; rs488991; rs617782; rs10916827; rs7515668; rs500534; rs557219; rs818201; rs526987; rs10916830; rs12127536; rs506586; rs7537761; rs12072407; rs2320237; rs11582454; rs12401770; rs546692; rs11580377; rs542038; rs12072411; rs10916831; rs7545140; rs472629; rs573337; rs818202; rs1253904; rs532545; rs6690069; rs10916832; rs10916833; rs10916822; rs552722; rs603412; rs17854868; rs35163879; rs3215400; rs528031; rs1048980; rs34306899; rs602946; rs35247557; rs5772909; rs35125816; rs35859441; rs36002777; rs12131589; rs34293111; rs35045423; rs36106578; rs34634228; rs35916142; rs12123808; rs12145503; rs34652519; rs12029060; rs11584381; rs35668998; rs7414028; rs35869652; rs11589869; rs9970283; rs28646077; rs35735696; rs12030776; rs12036909; rs35182793; rs12141867; rs12075735; rs12722974; rs1253482; rs12022958; rs34008190; rs10628782; rs12737642; rs6676236; rs34347193; rs12072318; rs12059454; rs12119997; rs12125531; rs12401583; rs1152993; rs35187698; rs4655228; rs34809737; rs6679821; rs35806956; rs12039573; rs34822300; rs1253481; rs12024909; rs6657978; rs11272233; rs11579996; rs35088359; rs34840123; rs34904959; rs818206; rs12120392; rs35234793; rs34988653; rs6688783; rs41467355; rs12740823; rs11591189; rs9970233; rs6665553; rs35285740; rs1689925; rs34995697; rs12143372; rs28591485; rs34722632; rs11334996; rs3072072; rs9970226; rs12029033; rs35351279; rs12731069; rs11580211; rs28743049; rs12752560; rs692943; rs12123445; rs12135846; rs34901070; rs35637551; rs35770611; rs34861922; rs5772908; rs34862360; rs7531198; rs12092374; rs4259612; rs1689926; rs12744559; rs12737656; rs34715988; rs4655227; rs34918162; rs34185271; rs12045976; rs10916823; rs12240109; rs12726436; rs476790; rs12117048; rs33942385; rs10601038; rs12095662; rs10711308; rs12128671; rs10753504; rs10916836; rs10916837; rs1572487; rs1614627; rs1689916; rs1781457; rs485716; rs485833; rs540282; rs586422; rs650264; rs652536; rs6687370; rs6695655; rs678980; rs680748

# Metabolic_Enzyme_2_General_References:
7923172; 9878810; 9596658; 8422236

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5938

# Metabolic_Enzyme_3_Name:
Protein-glutamine gamma-glutamyltransferase E precursor

# Metabolic_Enzyme_3_Synonyms:
TGase E; TGE; TG(E; Transglutaminase-3[Contains: Protein- glutamine gamma-glutamyltransferase E 50 kDa non-catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa catalytic chain]

# Metabolic_Enzyme_3_Gene_Name:
TGM3

# Metabolic_Enzyme_3_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase E precursor
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVST
GPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQ
GGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQ
FEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGT
YTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSA
HDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQER
SQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIG
RYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQE
PSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSAT
MSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLE
VLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFD
ILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE

# Metabolic_Enzyme_3_Number_of_Residues:
693

# Metabolic_Enzyme_3_Molecular_Weight:
76633

# Metabolic_Enzyme_3_Theoretical_pI:
5.60

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Not Available

# Metabolic_Enzyme_3_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. It is responsible for the later stages of cell envelope formation in the epidermis and the hair follicle

# Metabolic_Enzyme_3_Pathway:
Not Available

# Metabolic_Enzyme_3_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_3_GenBank_ID_Protein:
307504

# Metabolic_Enzyme_3_SwissProt_ID:
TGM3_HUMAN (Q08188)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
TGM3

# Metabolic_Enzyme_3_Geneatlas_id:
TGM3

# Metabolic_Enzyme_3_hgnc_id:
HGNC:11779

# Metabolic_Enzyme_3_PDB_ID:
1SGX

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>2082 bp
ATGGCTGCTCTAGGAGTCCAGAGTATCAACTGGCAGAAGGCCTTCAACCGACAAGCGCAT
CACACAGACAAGTTCTCCAGCCAGGAGCTCATCTTGCGGAGAGGCCAAAACTTCCAGGTC
TTAATGATCATGAACAAAGGCCTTGGCTCTAACGAAAGACTGGAGTTCATTGACACCACA
GGGCCTTACCCCTCAGAGTCGGCCATGACGAAGGCTGTGTTTCCACTCTCCAATGGCAGT
AGTGGTGGCTGGAGTGCGGTGCTTCAGGCCAGCAATGGCAATACTCTGACTATCAGCATC
TCCAGTCCTGCCAGCGCACCCATAGGACGGTACACAATGGCCCTCCAGATCTTCTCCCAG
GGCGGCATCTCCTCTGTGAAACTTGGGACGTTCATACTGCTTTTTAACCCCTGGCTGAAT
GTGGATAGCGTCTTTATGGGTAACCATGCTGAGAGAGAAGAGTATGTTCAGGAAGATGCC
GGCATCATCTTTGTGGGAAGCACAAACCGAATTGGCATGATTGGCTGGAACTTTGGACAG
TTTGAAGAAGACATTCTCAGCATCTGCCTCTCAATCTTGGATAGGAGTCTGAATTTCCGC
CGTGACGCTGCTACTGATGTGGCCAGCAGAAATGACCCCAAATACGTTGGCCGGGTGCTG
AGTGCCATGATCAATAGCAATGATGACAATGGTGTGCTTGCTGGGAATTGGAGCGGCACT
TACACCGGTGGCCGGGACCCAAGGAGCTGGGACGGCAGCGTGGAGATCCTCAAAAATTGG
AAAAAATCTGGCTTCAGCCCAGTCCGATATGGCCAGTGCTGGGTCTTTGCTGGGACCCTC
AACACAGCGCTGCGGTCTTTGGGGATTCCTTCCCGGGTGATCACCAACTTCAACTCAGCT
CATGACACAGACCGAAATCTCAGTGTGGATGTGTACTACGACCCCATGGGAAACCCCCTG
GACAAGGGTAGTGATAGCGTATGGAATTTCCATGTCTGGAATGAAGGCTGGTTTGTGAGG
TCTGACCTGGGCCCCCCGTACGGTGGATGGCAGGTGTTGGATGCTACCCCGCAGGAAAGA
AGCCAAGGGGTGTTCCAGTGCGGCCCCGCTTCGGTCATTGGTGTTCGAGAGGGTGATGTG
CAGCTGAACTTCGACATGCCCTTTATCTTCGCGGAGGTTAATGCCGACCGCATCACCTGG
CTGTACGACAACACCACTGGCAAACAGTGGAAGAATTCCGTGAACAGTCACACCATTGGC
AGGTACATCAGCACCAAGGCGGTGGGCAGCAATGCTCGCATGGACGTCACGGACAAGTAC
AAGTACCCAGAAGGCTCTGACCAGGAAAGACAAGTGTTCCAAAAGGCTTTGGGGAAACTT
AAACCCAACACGCCATTTGCCGCGACGTCTTCGATGGGTTTGGAAACAGAGGAACAGGAG
CCCAGCATCATCGGGAAGCTGAAGGTCGCTGGCATGCTGGCAGTAGGCAAAGAAGTCAAC
CTGGTCCTACTGCTCAAAAACCTGAGCAGGGATACGAAGACAGTGACAGTGAACATGACA
GCCTGGACCATCATCTACAACGGCACGCTTGTACATGAAGTGTGGAAGGACTCTGCCACA
ATGTCCCTGGACCCTGAGGAAGAGGCAGAACATCCCATAAAGATCTCGTACGCTCAGTAT
GAGAGGTACCTGAAGTCAGACAACATGATCCGGATCACAGCGGTGTGCAAGGTCCCAGAT
GAGTCTGAGGTGGTGGTGGAGCGGGACATCATCCTGGACAACCCCACCTTGACCCTGGAG
GTGCTGAACGAGGCTCGTGTGCGGAAGCCTGTGAACGTGCAGATGCTCTTCTCCAATCCA
CTGGATGAGCCGGTGAGGGACTGCGTGCTGATGGTGGAGGGAAGCGGCCTGCTGTTGGGT
AACCTGAAGATCGACGTGCCGACCCTAGGGCCCAAGGAGCGGTCCCGGGTCCGTTTTGAT
ATCCTGCCCTCCCGGAGTGGCACCAAGCAACTGCTCGCCGACTTCTCCTGCAACAAGTTC
CCTGCAATCAAGGCCATGTTGTCCATCGACGTAGCCGAATGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
L10386

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_3_Locus:
20q11.2

# Metabolic_Enzyme_3_SNPs:
rs214803; rs214814; rs6048066; rs214830; rs34234428; rs2228355; rs214831; rs214832; rs2013961; rs2422693; rs214819; rs214827; rs214806; rs1923099; rs1923101; rs214807; rs2076408; rs214776; rs3895160; rs214772; rs6036081; rs6048208; rs6106526; rs214764; rs214781; rs214774; rs214775; rs214818; rs6075897; rs2422687; rs214768; rs6048041; rs214766; rs6113720; rs214798; rs214763; rs6075916; rs214811; rs6132532; rs84825; rs2019155; rs214773; rs214812; rs6048154; rs214762; rs214828; rs214769; rs6106524; rs1012621; rs214783; rs16983952; rs11908614; rs214809; rs214793; rs214780; rs214804; rs214815; rs2014017; rs6417528; rs6048207; rs6048187; rs2014045; rs214765; rs214770; rs2012787; rs214784; rs6036162; rs11904869; rs214796; rs214799; rs2422690; rs11906667; rs1853092; rs214771; rs214801; rs2076406; rs214810; rs214786; rs6048053; rs214791; rs84823; rs6036147; rs214805; rs10485599; rs214782; rs214785; rs214817; rs214795; rs214792; rs6048188; rs11908571; rs6048070; rs2422691; rs2422692; rs7274152; rs214790; rs2076407; rs6048195; rs3865535; rs11907047; rs2076403; rs6137670; rs2422689; rs214794; rs7262933; rs6137695; rs11904909; rs214829; rs7263873; rs214823; rs6113756; rs6137668; rs6137716; rs84824; rs214797; rs4097062; rs8119589; rs6082720; rs6048122; rs6113688; rs2019184; rs2092378; rs214800; rs6036087; rs2013952; rs7353254; rs3838045; rs6137717; rs214824; rs214788; rs6036076; rs214813; rs6082659; rs6113687; rs8123507; rs3855686; rs1923100; rs11907640; rs6048182; rs214778; rs2019129; rs214789; rs6515233; rs4097063; rs6048037; rs16983963; rs13037722; rs214767; rs11907667; rs214820; rs6113629; rs214808; rs17312424; rs11906052; rs11907611; rs214787; rs11906430; rs214826; rs6036088; rs17312557; rs214821; rs214816; rs214777; rs6137715; rs214758; rs214833; rs214760; rs6106479; rs214757; rs214759; rs6047968; rs1126815; rs1042617; rs1126816; rs7262519; rs1042616; rs34742355; rs1042619; rs6137724; rs6048260; rs1062606; rs6048079; rs33929365; rs34552910; rs2013747; rs6082710; rs35613469; rs35684829; rs11473649; rs3787473; rs41279950; rs11467463; rs5839945; rs386361; rs6106537; rs5839946; rs35424996; rs214761; rs6113616; rs6036100; rs6075919; rs7352716; rs4815128; rs6113697; rs36069184; rs41279944; rs34227867; rs214779; rs7274208; rs6137600; rs5839949; rs34897899; rs34732762; rs11306743; rs6082722; rs6137617; rs36005182; rs126635; rs3046692; rs6132496; rs7266030; rs11475094; rs6137714; rs6137692; rs6137626; rs11480651; rs6137630; rs11480978; rs11477297; rs5839947; rs35229399; rs6113662; rs16983510; rs11408471; rs36098753; rs34389451; rs11087374; rs11480073; rs36058748; rs4077078; rs6082758; rs6137719; rs6082713; rs7362352; rs13041201; rs11308962; rs4815136; rs6048201; rs6132522; rs6137631; rs6137678; rs34217881; rs6137693; rs6036164; rs41306767; rs35904800; rs34536259; rs6048227; rs35246388; rs35225328; rs34774705; rs7272782; rs13039090; rs214825; rs6082768; rs6113659; rs6137720; rs6113661; rs6082703; rs2422688; rs6082760; rs11477461; rs35025891; rs5839950; rs7267044; rs33923737; rs12625643; rs33928865; rs34205972; rs11473001; rs8114748; rs41279946; rs214822; rs6047989; rs6048251; rs6082667; rs34969915; rs7347951; rs6137677; rs11905253; rs34926550; rs35785069; rs11087382; rs6048164; rs33957405; rs5839948; rs35046905; rs7265785; rs214802; rs8119361; rs34849269; rs35654167; rs6137686; rs7262802; rs7269873; rs6048266; rs2235610; rs1040789; rs13038817; rs1474682; rs1534979; rs214750; rs214751; rs214752; rs214755; rs214834; rs214835; rs214839; rs2422694; rs2422695; rs2422696; rs2422697; rs35729063; rs4813467; rs4815145; rs5022516; rs5022517; rs6036066; rs6047936; rs6047963; rs6048274; rs6048276; rs6048338; rs6048339; rs6048340; rs6082631; rs6082632; rs6082633; rs6082805; rs6082806; rs6082807; rs6106553; rs6106556; rs6113558; rs6113559; rs6113563; rs6113793; rs6137560; rs7266599; rs7274418

# Metabolic_Enzyme_3_General_References:
8099584; 11780052

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5939

# Metabolic_Enzyme_4_Name:
Glutamate dehydrogenase 2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
GDH

# Metabolic_Enzyme_4_Gene_Name:
GLUD2

# Metabolic_Enzyme_4_Protein_Sequence:
>Glutamate dehydrogenase 2, mitochondrial precursor
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
NAIEKVFKVYSEAGVTFT

# Metabolic_Enzyme_4_Number_of_Residues:
558

# Metabolic_Enzyme_4_Molecular_Weight:
61435

# Metabolic_Enzyme_4_Theoretical_pI:
8.67

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_4_Specific_Function:
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

# Metabolic_Enzyme_4_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_4_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_4_GenBank_ID_Protein:
31815

# Metabolic_Enzyme_4_SwissProt_ID:
DHE4_HUMAN (P49448)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
GLUD2

# Metabolic_Enzyme_4_Geneatlas_id:
GLUD2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:4336

# Metabolic_Enzyme_4_PDB_ID:
1L1F

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_4_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGCCAAAGCGCTGCTGCCGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCCGCGGCCAACCACTCGGCCGCGTTGCTGGGCCGGGGCCGCGGACAGCCCGCCGCCGCC
TCGCAGCCGGGGCTCGCATTGGCCGCCCGGCGCCACTACAGCGAGTTGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGTTGGTGAAGGACCTGAGGACCCAGGAAAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACCGAAAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAGAAGGGCTTTATTGGTCCTGGCGTTGAT
GTGCCTGCTCCAGACATGAACACAGGTGAGCGGGAGATGTCCTGGATTGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAACTTCATCAATCAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTAGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGTCGACTGTGACATACTGATC
CCAGCTGCCACTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGATAAGATCTTCCTGGAGAGA
AACATTTTGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCCTGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGTATATCGGGTGCA
TCTGAGAAAGACATTGTGCACTCTGCCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCACACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTC
AATGCCATTGAAAAAGTCTTCAAAGTGTACAGTGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
X66310

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_4_Locus:
Xq24-q25

# Metabolic_Enzyme_4_SNPs:
rs9697983; rs9780362; rs5909779; rs5911062; rs10657; rs1131121; rs28928873; rs41304944; rs1131120; rs12834131; rs3861; rs5956266; rs34294265; rs5956265; rs9698227; rs12836242; rs17329546; rs2375484; rs5956268; rs9699235; rs9778349

# Metabolic_Enzyme_4_General_References:
8207021

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5630

# Metabolic_Enzyme_5_Name:
Membrane copper amine oxidase

# Metabolic_Enzyme_5_Synonyms:
Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; HPAO

# Metabolic_Enzyme_5_Gene_Name:
AOC3

# Metabolic_Enzyme_5_Protein_Sequence:
>Membrane copper amine oxidase
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

# Metabolic_Enzyme_5_Number_of_Residues:
763

# Metabolic_Enzyme_5_Molecular_Weight:
84623

# Metabolic_Enzyme_5_Theoretical_pI:
6.51

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_5_Specific_Function:
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity

# Metabolic_Enzyme_5_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_5_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_5_Signals:
1-19

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_5_GenBank_ID_Protein:
1399032

# Metabolic_Enzyme_5_SwissProt_ID:
AOC3_HUMAN (Q16853)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
AOC3

# Metabolic_Enzyme_5_Geneatlas_id:
AOC3

# Metabolic_Enzyme_5_hgnc_id:
HGNC:550

# Metabolic_Enzyme_5_PDB_ID:
1PU4

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Membrane; single-pass type II membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>2292 bp
ATGAACCAGAAGACAATCCTCGTGCTCCTCATTCTGGCCGTCATCACCATCTTTGCCTTG
GTTTGTGTCCTGCTGGTGGGCAGGGGTGGAGATGGGGGTGAACCCAGCCAGCTTCCCCAT
TGCCCCTCTGTATCTCCCAGTGCCCAGCCTTGGACACACCCTGGCCAGAGCCAGCTGTTT
GCAGACCTGAGCCGAGAGGAGCTGACGGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGG
CCAGGGCTGGTGGATGCAGCCCAGGCCCGGCCCTCGGACAACTGTGTCTTCTCAGTGGAG
TTGCAGCTGCCTCCCAAGGCTGCAGCCCTGGCTCACTTGGACAGGGGGAGCCCCCCACCT
GCCCGGGAGGCACTGGCCATCGTCTTCTTTGGCAGGCAACCCCAGCCCAACGTGAGTGAG
CTGGTGGTGGGGCCACTGCCTCACCCCTCCTACATGCGGGACGTGACTGTGGAGCGTCAT
GGAGGCCCCCTGCCCTATCACCGACGCCCCGTGCTGTTCCAAGAGTACCTGGACATAGAC
CAGATGATCTTCAACAGAGAGCTGCCCCAGGCTTCTGGGCTTCTCCACCACTGTTGCTTC
TACAAGCACCGGGGACGGAACCTGGTGACAATGACCACGGCTCCCCGTGGTCTGCAATCA
GGGGACCGGGCCACCTGGTTTGGCCTCTACTACAACATCTCGGGCGCTGGGTTCTTCCTG
CACCACGTGGGCTTGGAGCTGCTAGTGAACCACAAGGCCCTTGACCCTGCCCGCTGGACT
ATCCAGAAGGTGTTCTATCAAGGCCGCTACTACGACAGCCTGGCCCAGCTGGAGGCCCAG
TTTGAGGCCGGCCTGGTGAATGTGGTGCTGATCCCAGACAATGGCACAGGTGGGTCCTGG
TCCCTGAAGTCCCCTGTGCCCCCGGGTCCAGCTCCCCCTCTACAGTTCTATCCCCAAGGC
CCCCGCTTCAGTGTCCAGGGAAGTCGAGTGGCCTCCTCACTGTGGACTTTCTCCTTTGGC
CTCGGAGCATTCAGTGGCCCAAGGATCTTTGACGTTCGCTTCCAAGGAGAAAGACTAGTT
TATGAGATAAGCCTCCAAGAGGCCTTGGCCATCTATGGTGGAAATTCCCCAGCAGCAATG
ACGACCCGCTATGTGGATGGAGGCTTTGGCATGGGCAAGTACACCACGCCCCTGACCCGT
GGGGTGGACTGCCCCTACTTGGCCACCTACGTGGACTGGCACTTCCTTTTGGAGTCCCAG
GCCCCCAAGACAATACGTGATGCCTTTTGTGTGTTTGAACAGAACCAGGGCCTCCCCCTG
CGGCGACACCACTCAGATCTCTACTCGCACTACTTTGGGGGTCTTGCGGAAACGGTGCTG
GTCGTCAGATCTATGTCCACCTTGCTCAACTATGACTATGTGTGGGATACGGTCTTCCAC
CCCAGTGGGGCCATAGAAATACGATTCTATGCCACGGGCTACATCAGCTCGGCATTCCTC
TTTGGTGCTACTGGGAAGTACGGGAACCAAGTGTCAGAGCACACCCTGGGCACGGTCCAC
ACCCACAGCGCCCACTTCAAGGTGGATCTGGATGTAGCAGGACTGGAGAACTGGGTCTGG
GCCGAGGATATGGTCTTTGTCCCCATGGCTGTGCCCTGGAGCCCTGAGCACCAGCTGCAG
AGGCTGCAGGTGACCCGGAAGCTGCTGGAGATGGAGGAGCAGGCCGCCTTCCTCGTGGGA
AGCGCCACCCCTCGCTACCTGTACCTGGCCAGCAACCACAGCAACAAGTGGGGTCACCCC
CGGGGCTACCGCATCCAGATGCTCAGCTTTGCTGGAGAGCCGCTGCCCCAAAACAGCTCC
ATGGCGAGAGGCTTCAGCTGGGAGAGGTACCAGCTGGCTGTGACCCAGCGGAAGGAGGAG
GAGCCCAGTAGCAGCAGCGTTTTCAATCAGAATGACCCTTGGGCCCCCACTGTGGATTTC
AGTGACTTCATCAACAATGAGACCATTGCTGGAAAGGATTTGGTGGCCTGGGTGACAGCT
GGTTTTCTGCATATCCCACATGCAGAGGACATTCCTAACACAGTGACTGTGGGGAACGGC
GTGGGCTTCTTCCTCCGACCCTATAACTTCTTTGACGAAGACCCCTCCTTCTACTCTGCC
GACTCCATCTACTTCCGAGGGGACCAGGATGCTGGGGCCTGCGAGGTCAACCCCCTAGCT
TGCCTGCCCCAGGCTGCTGCCTGTGCCCCCGACCTCCCTGCCTTCTCCCACGGGGGCTTC
TCTCACAACTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U39447

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
8972912; 9653080

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5940

# Metabolic_Enzyme_6_Name:
Protein-glutamine gamma-glutamyltransferase 2

# Metabolic_Enzyme_6_Synonyms:
Tissue transglutaminase; TGase C; TGC; TG(C; Transglutaminase-2; TGase- H

# Metabolic_Enzyme_6_Gene_Name:
TGM2

# Metabolic_Enzyme_6_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 2
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA

# Metabolic_Enzyme_6_Number_of_Residues:
687

# Metabolic_Enzyme_6_Molecular_Weight:
77330

# Metabolic_Enzyme_6_Theoretical_pI:
4.86

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Not Available

# Metabolic_Enzyme_6_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_6_Pathway:
Not Available

# Metabolic_Enzyme_6_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_6_Signals:
None

# Metabolic_Enzyme_6_Transmembrane_Regions:
None

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_6_GenBank_ID_Protein:
339521

# Metabolic_Enzyme_6_SwissProt_ID:
TGM2_HUMAN (P21980)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
TGM2

# Metabolic_Enzyme_6_Geneatlas_id:
TGM2

# Metabolic_Enzyme_6_hgnc_id:
HGNC:11778

# Metabolic_Enzyme_6_PDB_ID:
1KV3

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Not Available

# Metabolic_Enzyme_6_Gene_Sequence:
>2064 bp
ATGGCCGAGGAGCTGGTCTTAGAGAGGTGTGATCTGGAGCTGGAGACCAATGGCCGAGAC
CACCACACGGCCGACCTGTGCCGGGAGAAGCTGGTGGTGCGACGGGGCCAGCCCTTCTGG
CTGACCCTGCACTTTGAGGGCCGCAACTACCAGGCCAGTGTAGACAGTCTCACCTTCAGT
GTCGTGACCGGCCCAGCCCCTAGCCAGGAGGCCGGGACCAAGGCCCGTTTTCCACTAAGA
GATGCTGTGGAGGAGGGTGACTGGACAGCCACCGTGGTGGACCAGCAAGACTGCACCCTC
TCGCTGCAGCTCACCACCCCGGCCAACGCCCCCATCGGCCTGTATCGCCTCAGCCTGGAG
GCCTCCACTGGCTACCAGGGATCCAGCTTTGTGCTGGGCCACTTCATTTTGCTCTTCAAC
GCCTGGTGCCCAGCGGATGCTGTGTACCTGGACTCGGAAGAGGAGCGGCAGGAGTATGTC
CTCACCCAGCAGGGCTTTATCTACCAGGGCTCGGCCAAGTTCATCAAGAACATACCTTGG
AATTTTGGGCAGTTTCAAGATGGGATCCTAGACATCTGCCTGATCCTTCTAGATGTCAAC
CCCAAGTTCCTGAAGAACGCCGGCCGTGACTGCTCCCGGCGCAGCAGCCCCGTCTACGTG
GGCCGGGTGGGTAGTGGCATGGTCAACTGCAACGATGACCAGGGTGTGCTGCTGGGACGC
TGGGACAACAACTACGGGGACGGCGTCAGCCCCATGTCCTGGATCGGCAGCGTGGACATC
CTGCGGCGCTGGAAGAACCACGGCTGCCAGCGCGTCAAGTATGGCCAGTGCTGGGTCTTC
GCCGCCGTGGCCTGCACAGTGCTGAGGTGCCTAGGCATCCCTACCCGCGTCGTGACCAAC
TACAACTCGGCCCATGACCAGAACAGCAACCTTCTCATCGAGTACTTCCGCAATGAGTTT
GGGGAGATCCAGGGTGACAAGAGCGAGATGATCTGGAACTTCCACTGCTGGGTGGAGTCG
TGGATGACCAGGCCGGACCTGCAGCCGGGGTACGAGGGCTGGCAGGCCCTGGACCCAACG
CCCCAGGAGAAGAGCGAAGGAACGTACTGCTGTGGCCCAGTTCCAGTTCGTGCCATCAAG
GAGGGCGACCTGAGCACCAAGTACGATGCGCCCTTTGTCTTTGCGGAGGTCAATGCCGAC
GTGGTAGACTGGATCCAGCAGGACGATGGGTCTGTGCACAAATCCATCAACCGTTCCCTG
ATCGTTGGGCTGAAGATCAGCACTAAGAGCGTGGGCCGAGACGAGCGGGAGGATATCACC
CACACCTACAAATACCCAGAGGGGTCCTCAGAGGAGAGGGAGGCCTTCACAAGGGCGAAC
CACCTGAACAAACTGGCCGAGAAGGAGGAGACAGGGATGGCCATGCGGATCCGTGTGGGC
CAGAGCATGAACATGGGCAGTGACTTTGACGTCTTTGCCCACATCACCAACAACACCGCT
GAGGAGTACGTCTGCCGCCTCCTGCTCTGTGCCCGCACCGTCAGCTACAATGGGATCTTG
GGGCCCGAGTGTGGCACCAAGTACCTGCTCAACCTAACCCTGGAGCCTTTCTCTGAGAAG
AGCGTTCCTCTTTGCATCCTCTATGAGAAATACCGTGACTGCCTTACGGAGTCCAACCTC
ATCAAGGTGCGGGCCCTCCTCGTGGAGCCAGTTATCAACAGCTACCTGCTGGCTGAGAGG
GACCTCTACCTGGAGAATCCAGAAATCAAGATCCGGATCCTTGGGGAGCCCAAGCAGAAA
CGCAAGCTGGTGGCTGAGGTGTCCCTGCAGAACCCGCTCCCTGTGGCCCTGGAAGGCTGC
ACCTTCACTGTGGAGGGGGCCGGCCTGACTGAGGAGCAGAAGACGGTGGAGATCCCAGAC
CCCGTGGAGGCAGGGGAGGAAGTTAAGGTGAGAATGGACCTCGTGCCGCTCCACATGGGC
CTCCACAAGCTGGTGGTGAACTTCGAGAGCGACAAGCTGAAGGCTGTGAAGGGCTTCCGG
AATGTCATCATTGGCCCCGCCTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M55153

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_6_Locus:
20q12

# Metabolic_Enzyme_6_SNPs:
rs2294545; rs2235581; rs2076390; rs1044932; rs2284879; rs6123388; rs7271155; rs4811529; rs2284881; rs2076385; rs2076378; rs6023526; rs6023476; rs2284877; rs2076380; rs6023511; rs4811528; rs1555074; rs6023533; rs2076387; rs16987150; rs2076383; rs7270785; rs7270898; rs11696730; rs6123394; rs2284878; rs2076389; rs2268909; rs2076391; rs2268912; rs12624511; rs2076388; rs2268910; rs2067027; rs6014121; rs6127224; rs2284882; rs2268911; rs16987159; rs11907951; rs2072951; rs6127225; rs2281197; rs2268908; rs2076386; rs8118753; rs2076377; rs17196913; rs7270605; rs17789803; rs17789815; rs17197018; rs6512993; rs2076379; rs13040190; rs7275079; rs2076384; rs6127240; rs7265437; rs6023527; rs8116393; rs6023418; rs7271165; rs12481711; rs6023525; rs17196927; rs2268907; rs2281198; rs2284880; rs17789761; rs2235583; rs6127200; rs2076381; rs2235582; rs2076382; rs7272112; rs41274720; rs35700485; rs1062735; rs41274716; rs2229470; rs6023252; rs2229471; rs2229472; rs35434048; rs1804502; rs11387; rs6097978; rs36046775; rs11550896; rs1804503; rs2281196; rs7270628; rs1062737; rs6097985; rs1062736; rs1044857; rs6068886; rs6023279; rs5018735; rs5841287; rs6091906; rs34548736; rs6023597; rs35284639; rs6127242; rs6091943; rs8117902; rs17787661; rs11469099; rs6023414; rs6127267; rs6098150; rs35780805; rs8114400; rs13040847; rs34739100; rs6068885; rs10699981; rs10699740; rs6098131; rs6023598; rs34654943; rs6091944; rs8124100; rs6068900; rs11471691; rs6091968; rs6098128; rs8183332; rs41274712; rs6091945; rs6068899; rs35004302; rs6023334; rs8123979; rs34607641; rs6098189; rs35565395; rs7363366; rs34321768; rs6023452; rs2268906; rs11468662; rs6098132; rs6098085; rs11269756; rs4811518; rs8121932; rs11468425; rs6023490; rs9636518; rs10616642; rs12481464; rs11470829; rs6091926; rs6014113; rs34897797; rs7268761; rs34622978; rs35107341; rs6127243; rs35785941; rs35526991; rs2294544; rs6098144; rs6098100; rs6023588; rs34046288; rs6023261; rs6023306; rs13041056; rs6098012; rs6068979; rs34211491; rs6068984; rs13045658; rs6068985; rs36103548; rs13037122; rs11469340; rs34175510; rs11086467; rs11086468; rs11698193; rs11698249; rs11698616; rs11698668; rs11700009; rs11700046; rs11700099; rs12480485; rs12624989; rs12626000; rs13040344; rs13040645; rs13043826; rs13045359; rs13045391; rs13045748; rs13045832; rs17197200; rs17197207; rs17790012; rs1883484; rs34773869; rs34784193; rs6013988; rs6013993; rs6014186; rs6014193; rs6023630; rs6023637; rs6023651; rs6023654; rs6023676; rs6064122; rs6069014; rs6069015; rs6097929; rs6098295; rs742414; rs760999; rs761001; rs761002; rs761003; rs8116328; rs8121713

# Metabolic_Enzyme_6_General_References:
1670766; 1358880; 8611626; 11780052

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5941

# Metabolic_Enzyme_7_Name:
Protein-arginine deiminase type-6

# Metabolic_Enzyme_7_Synonyms:
Protein-arginine deiminase type VI; Peptidylarginine deiminase VI

# Metabolic_Enzyme_7_Gene_Name:
PADI6

# Metabolic_Enzyme_7_Protein_Sequence:
>Proteinarginine deiminase type6
MSFQSIIHLSLDSPVHAVCVLGTEICLDLSGCAPQKCQCFTIHGSGRVLIDVANTVISEK
EDATIWWPLSDPTYATVKMTSPSPSVDADKVSVTYYGPNEDAPVGTAVLYLTGIEVSLEV
DIYRNGQVEMSSDKQAKKKWIWGPSGWGAILLVNCNPADVGQQLEDKKTKKVIFSEEITN
LSQMTLNVQGPSCILKKYRLVLHTSKEESKKARVYWPQKDNSSTFELVLGPDQHAYTLAL
LGNHLKETFYVEAIAFPSAEFSGLISYSVSLVEESQDPSIPETVLYKDTVVFRVAPCVFI
PCTQVPLEVYLCRELQLQGFVDTVTKLSEKSNSQVASVYEDPNRLGRWLQDEMAFCYTQA
PHKTTSLILDTPQAADLDEFPMKYSLSPGIGYMIQDTEDHKVASMDSIGNLMVSPPVKVQ
GKEYPLGRVLIGSSFYPSAEGRAMSKTLRDFLYAQQVQAPVELYSDWLMTGHVDEFMCFI
PTDDKNEGKKGFLLLLASPSACYKLFREKQKEGYGDALLFDELRADQLLSNGREAKTIDQ
LLADESLKKQNEYVEKCIHLNRDILKTELGLVEQDIIEIPQLFCLEKLTNIPSDQQPKRS
FARPYFPDLLRMIVMGKNLGIPKPFGPQIKGTCCLEEKICCLLEPLGFKCTFINDFDCYL
TEVGDICACANIRRVPFAFKWWKMVP

# Metabolic_Enzyme_7_Number_of_Residues:
686

# Metabolic_Enzyme_7_Molecular_Weight:
76898

# Metabolic_Enzyme_7_Theoretical_pI:
4.90

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo

# Metabolic_Enzyme_7_Pathway:
Not Available

# Metabolic_Enzyme_7_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_7_Signals:
None

# Metabolic_Enzyme_7_Transmembrane_Regions:
None

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_7_GenBank_ID_Protein:
40068449

# Metabolic_Enzyme_7_SwissProt_ID:
PADI6_HUMAN (Q6TGC4)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
PADI6

# Metabolic_Enzyme_7_Geneatlas_id:
PADI6

# Metabolic_Enzyme_7_hgnc_id:
HGNC:20449

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Cytoplasm. Nucleus (By similarity)

# Metabolic_Enzyme_7_Gene_Sequence:
>2085 bp
ATGGTCAGCGTGGAGGGCCGAGCCATGTCCTTCCAGAGTATCATCCACCTGTCCCTGGAC
AGCCCTGTCCATGCCGTTTGTGTGTTGGGCACAGAAATCTGCTTGGATCTCAGCGGGTGT
GCCCCCCAGAAGTGCCAGTGCTTCACCATCCATGGCTCTGGGAGGGTCTTGATCGATGTG
GCCAACACGGTGATTTCTGAGAAGGAGGACGCCACCATCTGGTGGCCCCTGTCTGATCCC
ACGTACGCCACAGTGAAGATGACATCGCCCAGCCCTTCCGTGGATGCGGATAAGGTCTCG
GTCACATACTATGGGCCCAACGAGGATGCCCCCGTGGGCACAGCTGTGCTGTACCTCACT
GGCATTGAGGTCTCTCTAGAGGTAGACATCTACCGCAATGGGCAAGTTGAGATGTCAAGT
GACAAACAGGCTAAGAAAAAATGGATCTGGGGTCCCAGCGGTTGGGGTGCCATCCTGCTT
GTGAATTGCAACCCTGCTGATGTGGGCCAGCAACTTGAGGACAAGAAAACCAAGAAAGTG
ATCTTTTCAGAGGAAATAACGAATCTGTCCCAGATGACTCTGAATGTCCAAGGCCCCAGC
TGTATCTTAAAGAAATATCGGCTAGTCCTCCATACCTCCAAGGAAGAGTCGAAGAAGGCG
AGAGTCTACTGGCCCCAAAAAGACAACTCCAGTACCTTTGAGTTGGTGCTGGGGCCCGAC
CAGCACGCCTATACCTTGGCCCTCCTCGGGAACCACTTGAAGGAGACTTTCTACGTTGAA
GCTATAGCATTCCCATCTGCCGAATTCTCAGGCCTCATCTCCTACTCTGTGTCCCTGGTG
GAGGAGTCTCAAGACCCGTCAATTCCAGAGACTGTGCTGTACAAAGACACGGTGGTGTTC
CGGGTGGCTCCCTGTGTCTTCATTCCCTGTACCCAGGTGCCTCTGGAGGTTTACCTGTGC
AGGGAGCTGCAGCTGCAGGGTTTTGTGGACACAGTGACGAAGCTGAGTGAGAAGAGCAAC
AGCCAGGTGGCATCTGTCTATGAGGACCCCAACCGCCTGGGCAGGTGGCTCCAGGATGAG
ATGGCCTTCTGCTACACCCAGGCTCCCCACAAGACAACGTCCTTGATCCTCGACACACCT
CAGGCCGCCGATCTCGATGAGTTCCCCATGAAGTACTCACTGAGCCCTGGTATTGGCTAC
ATGATCCAGGACACTGAGGACCATAAAGTGGCCAGCATGGATTCCATTGGGAACCTGATG
GTGTCCCCACCTGTCAAGGTCCAAGGGAAAGAGTACCCGCTGGGCAGAGTCCTCATTGGC
AGCAGCTTTTACCCCAGCGCAGAGGGCCGGGCCATGAGTAAGACCCTCCGAGACTTCCTC
TATGCCCAGCAGGTCCAAGCGCCGGTGGAGCTCTACTCAGATTGGCTAATGACTGGCCAC
GTGGATGAGTTCATGTGCTTCATCCCCACAGATGACAAGAATGAGGGCAAAAAGGGCTTC
CTGCTGCTCCTGGCCAGCCCCAGTGCCTGCTATAAACTGTTCCGAGAGAAACAGAAGGAA
GGCTATGGCGACGCTCTTCTGTTTGATGAGCTTAGAGCAGATCAGCTCCTGTCTAATGGA
AGGGAAGCCAAAACCATCGACCAACTTCTGGCTGATGAAAGCCTGAAGAAGCAGAATGAA
TACGTGGAGAAGTGCATTCACCTGAACCGTGACATCCTGAAGACGGAGCTGGGCCTGGTG
GAACAGGACATCATCGAGATTCCCCAGCTGTTCTGCTTGGAGAAGCTGACTAACATCCCC
TCTGACCAGCAGCCCAAGAGGTCCTTTGCGAGGCCATACTTCCCTGACCTGTTGCGGATG
ATTGTGATAGGCAAGAACCTGGGGATCCCCAAGCCTTTTGGGCCCCAAATCAAGGGGACC
TGCTGCCTGGAAGAAAAGATTTGCTGCTTGCTGGAGCCCCTGGGCTTCAAGTGCACCTTC
ATCAATGACTTTGACTGTTACCTGACAGAGGTCGGAGACATCTGTGCCTGTGCCAACATC
CGCCGGGTGCCCTTTACCTTCAAATGGTGGAAGATGGTACCTTAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
AY422079

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_7_Locus:
1p36.13

# Metabolic_Enzyme_7_SNPs:
rs2526830; rs1204873; rs11584277; rs1535876; rs2526844; rs2181867; rs2762895; rs2762894; rs2800688; rs1204871; rs2248453; rs2762896; rs7529038; rs1544066; rs6678552; rs2526839; rs2762893; rs2800691; rs12563231; rs10788668; rs4920602; rs2526840; rs1544067; rs1544068; rs7545115; rs11590561; rs7538876; rs7545226; rs6669650; rs6656582; rs2526842; rs6691485; rs2526836; rs7523430; rs942459; rs7513817; rs6695097; rs6678121; rs2762892; rs6695849; rs2526841; rs6666031; rs10458537; rs2800689; rs7545237; rs6678027; rs12737852; rs2526833; rs2265027; rs2526837; rs6696295; rs2800690; rs1535875; rs6678127; rs6695214; rs1204898; rs4920603; rs10158217; rs11803961; rs16826190; rs6687773; rs12068882; rs6666424; rs1204866; rs2248452; rs6703392; rs2248568; rs12124893; rs2800693; rs11203377; rs6658538; rs2526834; rs1555663; rs6663329; rs6695531; rs11803970; rs1204867; rs2248812; rs2800692; rs12073549; rs1204868; rs10458538; rs11577716; rs11203376; rs6695640; rs12025170; rs12127366; rs12239645; rs6664321; rs1535877; rs2800694; rs2248450; rs1204864; rs7519272; rs12752370; rs6586535; rs6700319; rs6687881; rs2308230; rs10888032; rs11800039; rs1204869; rs7556072; rs12127405; rs1924553; rs10888028; rs1204872; rs6657529; rs11583480; rs2489606; rs7523534; rs10888031; rs1204875; rs1204880; rs1204876; rs2526829; rs12760347; rs1204874; rs16825990; rs2107681; rs1204877; rs1204879; rs12753129; rs1204878; rs34167614; rs2489608; rs2762898; rs12023647; rs34009697; rs2526831; rs12128561; rs35174721; rs12031545; rs12129196; rs34553706; rs28449475; rs34042084; rs34037282; rs12736038; rs7533691; rs2265729; rs2526835; rs12132237; rs1204900; rs12129263; rs12071723; rs34308317; rs10690473; rs35811755; rs35164410; rs35274905; rs35046597; rs35288737; rs35197313; rs1924556; rs5772756; rs35871277; rs3035574; rs7553780; rs12132197; rs3094884; rs11338972; rs3035576; rs34171437; rs28416873; rs34761211; rs11584962; rs34548121; rs35317817; rs34383177; rs1555657; rs35411562; rs34724514; rs16826167; rs2800695; rs35226820; rs34852297; rs5772757; rs11584850; rs12134662; rs10709483; rs34075690; rs35726973; rs35213099; rs10158844; rs34586605; rs11309669; rs35317545; rs12028068; rs12023951; rs34944809; rs35968619; rs34543932; rs35163797; rs36067110; rs2477149; rs34438954; rs1924555; rs35154138; rs1204899; rs35775800; rs11584417; rs34518731; rs34520845; rs11800087; rs34330993; rs2526843; rs12079277; rs11410245; rs1555656; rs2489607; rs34766695; rs34018214; rs1204865; rs12033821; rs1555662; rs1211389; rs2526832; rs3074251; rs1204901; rs2265728; rs1924554; rs2762897; rs35813335; rs7541044; rs11203375; rs12743482; rs7540925; rs11203374; rs11583421; rs11801266; rs11809800; rs1204881; rs1204882; rs1204883; rs1204884; rs1204890; rs1204891; rs1204892; rs1204897; rs12059782; rs12096509; rs12098152; rs12732819; rs12760504; rs1408422; rs1408423; rs1555661; rs1969829; rs2244936; rs2477150; rs2526827; rs2762887; rs2762889; rs2762890; rs2800699; rs3094885; rs3752351; rs6690363; rs717612; rs7512868; rs7513051; rs7534816; rs7538597

# Metabolic_Enzyme_7_General_References:
Not Available

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5230

# Metabolic_Enzyme_8_Name:
Deoxycytidylate deaminase

# Metabolic_Enzyme_8_Synonyms:
dCMP deaminase

# Metabolic_Enzyme_8_Gene_Name:
DCTD

# Metabolic_Enzyme_8_Protein_Sequence:
>Deoxycytidylate deaminase
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGC
SDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQA
GIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ

# Metabolic_Enzyme_8_Number_of_Residues:
178

# Metabolic_Enzyme_8_Molecular_Weight:
20016

# Metabolic_Enzyme_8_Theoretical_pI:
7.65

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
Supplies the nucleotide substrate for thymidylate synthetase

# Metabolic_Enzyme_8_Pathway:
map00240  Pyrimidine metabolism;
 map03090  Type II secretion system

# Metabolic_Enzyme_8_Reaction:
dCMP + H2O = dUMP + ammonia

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00383:dCMP_cyt_deam_1

# Metabolic_Enzyme_8_Signals:
None

# Metabolic_Enzyme_8_Transmembrane_Regions:
None

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 3.5.4.12

# Metabolic_Enzyme_8_GenBank_ID_Protein:
181537

# Metabolic_Enzyme_8_SwissProt_ID:
DCTD_HUMAN (P32321)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
DCTD

# Metabolic_Enzyme_8_Geneatlas_id:
DCTD

# Metabolic_Enzyme_8_hgnc_id:
HGNC:2710

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_8_Gene_Sequence:
>537 bp
ATGAGTGAAGTTTCCTGCAAGAAACGGGACGACTATTTGGAATGGCCAGAGTATTTTATG
GCTGTGGCCTTCTTATCAGCACAGAGAAGCAAAGATCCAAATTCCCAGGTCGGCGCCTGC
ATCGTGAATTCAGAAAACAAGATTGTCGGGATTGGGTACAATGGGATGCCAAATGGGTGC
AGTGATGACGTGTTGCCTTGGAGAAGGACAGCAGAGAATAAGCTGGACACCAAATACCCG
TACGTGTGCCATGCGGAGCTGAATGCCATCATGAACAAAAATTCGACCGATGTGAAAGGC
TGTAGTATGTATGTCGCCTTGTTCCCTTGTAATGAATGCGCTAAGCTCATCATCCAGGCA
GGTATAAAAGAAGTGATTTTCACGTCTGATAAATACCATGATAGTGACGAGGCAACTGCT
GCGAGGCTCCTGTTTAATATGGCCGGGGTGACATTCCGGAAATTCATACCGAAGTGCAGC
AAGATTGTCATTGACTTTGATTCAATTAACAGCAGACCGAGTCAAAAGCTTCAGTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
L12136

# Metabolic_Enzyme_8_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_8_Locus:
4q35.1

# Metabolic_Enzyme_8_SNPs:
rs7663494; rs6552619; rs35431896; rs7277; rs9542; rs7278; rs3190314; rs3088349; rs1130902; rs851; rs13114262; rs3811810; rs7662393; rs2515683; rs6834019; rs9993882; rs12499918; rs7688644; rs6552622; rs6552621; rs6552620; rs10016530; rs1960207; rs9990999; rs2464974; rs9993866; rs12507552; rs13116598; rs17074237; rs6831306; rs13139377; rs13148414; rs11730323; rs6823077; rs17331744; rs10520543; rs10009825; rs13143433; rs17331968; rs10017797; rs7688234; rs3886768; rs4546291; rs13119957; rs2709338; rs13125711; rs2854557; rs13117591; rs13150570; rs13101260; rs11944044; rs2854559; rs7695216; rs13147196; rs13111117; rs13114435; rs13116494; rs1960206; rs2070805; rs2709339; rs13143259; rs6854046; rs3886767; rs17074241; rs17272416; rs17272827; rs6834432; rs11943452; rs17074230; rs2006129; rs13117700; rs34691926; rs3895619; rs13137332; rs7677967; rs6835318; rs6829021; rs11132157; rs6829309; rs11132159; rs6834938; rs17271644; rs11945824; rs12644483; rs17074255; rs11132158; rs6834968; rs17271665; rs7670780; rs17074179; rs17849458; rs35932500; rs13115133; rs34258479; rs2854558; rs1803485; rs11542955; rs978; rs4371655; rs2854556; rs34601043; rs34694727; rs34180264; rs35991374; rs35657813; rs10001362; rs34737293; rs11378889; rs13130566; rs34191514; rs28395501; rs2709340; rs35619807; rs2464971; rs2464970; rs35369968; rs35677082; rs34615053; rs34446316; rs34895822; rs17331996; rs13132293; rs34832772; rs33980005; rs34915632; rs2709342; rs35309711; rs28433797; rs12498969; rs33920727; rs7678108; rs10547938; rs13143535; rs5864809; rs2709345; rs35975848; rs34083060; rs34254701; rs35058226; rs36106622; rs13106308; rs2854553; rs35733975; rs2464969; rs35563105; rs34342056; rs7440120; rs28373940; rs2854554; rs34429408; rs2709344; rs35792362; rs34577883; rs35582993; rs35092526; rs13105019; rs13131376; rs34891001; rs2709341; rs6838091; rs28666432; rs17332045; rs28490576; rs2515682; rs13136805; rs34675565; rs13123593; rs17074254; rs35418900; rs35317026; rs35537259; rs6856058; rs35212179; rs35709318; rs13137448; rs6852733; rs35337615; rs35515009; rs34709418; rs34162150; rs2854555; rs35175712; rs13131621; rs13117695; rs4541550; rs34952576; rs36086271; rs35583609; rs34090309; rs34860877; rs34272834; rs6811849; rs35549969; rs33954687; rs7678159; rs28579927; rs10005703; rs10011977; rs11726024; rs13116781; rs17074171; rs17074271; rs17074273; rs17074277; rs3924787; rs3924788; rs3924789; rs4073674; rs4073675; rs4073676; rs4266328; rs4421026; rs4518294; rs4522909; rs4579170; rs4861536; rs4862127; rs5016499; rs5024188; rs6842533; rs7663810; rs7663998; rs7698606

# Metabolic_Enzyme_8_General_References:
7685356; 7642519

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5942

# Metabolic_Enzyme_9_Name:
Coagulation factor XIII B chain precursor

# Metabolic_Enzyme_9_Synonyms:
Protein-glutamine gamma- glutamyltransferase B chain; Transglutaminase B chain; Fibrin- stabilizing factor B subunit

# Metabolic_Enzyme_9_Gene_Name:
F13B

# Metabolic_Enzyme_9_Protein_Sequence:
>Coagulation factor XIII B chain precursor
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
T

# Metabolic_Enzyme_9_Number_of_Residues:
661

# Metabolic_Enzyme_9_Molecular_Weight:
75511

# Metabolic_Enzyme_9_Theoretical_pI:
6.36

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Not Available

# Metabolic_Enzyme_9_Specific_Function:
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin

# Metabolic_Enzyme_9_Pathway:
Not Available

# Metabolic_Enzyme_9_Reaction:
Not Available

# Metabolic_Enzyme_9_Pfam_Domain_Function:
PF00084:Sushi

# Metabolic_Enzyme_9_Signals:
1-20

# Metabolic_Enzyme_9_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_9_GenBank_ID_Protein:
179417

# Metabolic_Enzyme_9_SwissProt_ID:
F13B_HUMAN (P05160)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
F13B

# Metabolic_Enzyme_9_Geneatlas_id:
F13B

# Metabolic_Enzyme_9_hgnc_id:
HGNC:3534

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Not Available

# Metabolic_Enzyme_9_Gene_Sequence:
>1986 bp
ATGAGGTTGAAAAACCTGACTTTTATCATCATATTGATAATCTCAGGAGAACTCTATGCA
GAAGAGAAACCCTGTGGTTTTCCTCATGTGGAAAATGGAAGAATTGCCCAATATTACTAT
ACTTTTAAAAGCTTTTACTTTCCAATGAGCATAGACAAAAAATTGTCATTTTTCTGCTTG
GCTGGTTATACCACTGAAAGTGGAAGACAAGAAGAGCAAACCACGTGTACAACAGAAGGC
TGGTCTCCAGAGCCAAGGTGCTTCAAAAAATGCACTAAGCCTGACCTGAGTAATGGTTAC
ATCTCTGATGTAAAGTTATTGTATAAAATTCAAGAGAACATGCATTATGGTTGCGCTTCA
GGGTACAAAACCACTGGAGGGAAGGATGAAGAAGTGGTTCAATGTCTCTCTGATGGATGG
TCTTCTCAACCAACCTGTAGGAAAGAACATGAAACGTGTTTGGCTCCTGAATTATATAAT
GGAAATTATTCCACAACACAGAAAACATTCAAAGTGAAGGACAAAGTACAATACGAATGT
GCTACTGGCTACTACACAGCTGGAGGAAAGAAGACAGAGGAGGTAGAATGTCTCACATAC
GGATGGTCTCTCACACCAAAATGTACCAAATTAAAGTGCTCTTCTTTAAGATTAATTGAA
AATGGTTATTTTCATCCTGTAAAGCAAACCTATGAAGAAGGAGATGTCGTTCAGTTTTTC
TGTCATGAAAATTATTATCTAAGTGGATCTGATTTAATTCAATGCTATAACTTTGGTTGG
TACCCAGAATCTCCTGTATGCGAAGGAAGAAGAAACAGATGTCCTCCTCCACCTCTGCCC
ATAAACTCCAAAATTCAAACACATTCAACAACTTATCGTCATGGAGAAATAGTTCATATA
GAATGTGAACTTAATTTTGAGATCCATGGGTCAGCAGAAATACGTTGTGAAGATGGAAAA
TCGACAGAACCTCCAAAATGCATTGAAGGACAGGAGAAGGTAGCCTGTGAGGAACCACCC
TTCATTGAAAATGGTGCAGCAAATTTACACTCTAAGATTTATTACAATGGGGATAAAGTG
ACATATGCATGTAAAAGCGGCTACCTTCTCCATGGATCGAATGAGATAACTTGTAATCGT
GGAAAATGGACACTTCCTCCTGAGTGTGTTGAAAATAATGAGAATTGTAAGCATCCTCCT
GTTGTAATGAATGGGGCTGTTGCAGACGGGATATTGGCAAGCTATGCAACAGGATCCTCA
GTGGAATATAGATGCAATGAATATTACTTACTGAGGGGATCAAAAATATCTCGTTGCGAA
CAAGGAAAATGGTCATCCCCACCTGTTTGCTTGGAACCATGTACTGTTAATGTGGATTAC
ATGAACAGAAATAACATAGAAATGAAGTGGAAATATGAAGGGAAAGTCTTACATGGAGAT
TTAATAGATTTTGTATGTAAACAGGGATATGACTTATCTCCATTAACCCCATTGTCTGAA
TTATCTGTGCAGTGCAACAGAGGAGAAGTGAAATATCCTTTATGTACTAGAAAAGAATCT
AAAGGAATGTGCACATCTCCTCCTCTTATTAAACATGGAGTCATTATTAGTTCAACAGTA
GACACCTATGAAAATGGCTCTTCAGTAGAATACAGATGTTTTGATCACCATTTCCTAGAA
GGATCTAGGGAGGCCTATTGTTTAGATGGAATGTGGACTACACCACCATTGTGTTTAGAG
CCATGCACATTATCTTTTACTGAAATGGAAAAGAATAATTTACTTCTGAAATGGGATTTT
GACAACAGACCACACATTTTGCATGGTGAATATATTGAGTTTATTTGTAGAGGAGATACT
TATCCAGCTGAATTATATATTACTGGATCTATACTTAGAATGCAATGTGACAGAGGGCAG
TTAAAATATCCAAGATGTATTCCAAGACAAAGCACTCTGTCTTATCAAGAACCCTTAAGA
ACATAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
M64554

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_9_Locus:
1q31-q32.1

# Metabolic_Enzyme_9_SNPs:
rs6003; rs5999; rs6000; rs5998; rs5994; rs5997; rs698859; rs17549873; rs1759013; rs1615413; rs857026; rs5990; rs2990510; rs1611982; rs5996; rs857018; rs1627765; rs1412635; rs2298882; rs1412633; rs857020; rs10801586; rs10754211; rs10754210; rs7518773; rs1794003; rs1759006; rs1332661; rs2298883; rs5993; rs1759009; rs1412634; rs1759007; rs11587174; rs10640299; rs17514606; rs12134960; rs857024; rs1102176; rs865071; rs4915148; rs7517428; rs1759008; rs6669388; rs11586343; rs17549589; rs6669176; rs857017; rs11311263; rs10484502; rs17514514; rs857025; rs17549277; rs6669374; rs857027; rs10754209; rs17514662; rs17549603; rs17514324; rs17549657; rs17549381; rs17549755; rs17514507; rs17514528; rs17514570; rs17514556; rs17549540; rs17549769; rs17514591; rs17549430; rs17514802; rs17549547; rs17514577; rs17514382; rs17514274; rs17549624; rs17549734; rs17514396; rs17514355; rs17549776; rs17514795; rs17514362; rs17549312; rs17514627; rs17514634; rs17514669; rs11810678; rs17514403; rs17514521; rs17514309; rs17549650; rs17549617; rs17549664; rs17514535; rs17549582; rs17514732; rs10922158; rs17549797; rs17514760; rs17549360; rs17549818; rs17514823; rs17549596; rs17514584; rs17514739; rs17514781; rs17514725; rs17549866; rs17514767; rs17549859; rs17549256; rs17514676; rs17514317; rs1412632; rs1412631; rs13375369; rs857021; rs1115246; rs1115247; rs857023; rs17549514; rs17514851; rs5991; rs12752075; rs17549671; rs17514281; rs12732168; rs6001; rs6002; rs12752091; rs2990511; rs17514253; rs5992; rs36059396; rs35313992; rs10574253; rs35445601; rs17514288; rs17549783; rs17549790; rs17514480; rs1759012; rs17514232; rs17514746; rs13375546; rs17549388; rs35716835; rs17514704; rs7542706; rs17549643; rs17514542; rs17514697; rs17549706; rs1794007; rs17514376; rs1759010; rs17514648; rs1794004; rs17549416; rs17514239; rs17514809; rs12734951; rs17549575; rs17549465; rs17549762; rs17514487; rs12735136; rs17514302; rs17549748; rs17514816; rs17549533; rs17514641; rs17549554; rs12139015; rs17514369; rs34101135; rs17514753; rs1794009; rs17549839; rs17549713; rs17514620; rs17549699; rs17549631; rs17549853; rs17514613; rs12735137; rs17549561; rs17549741; rs17549804; rs17549568; rs17549846; rs17514683; rs857019; rs1759011; rs12753471; rs35806759; rs34632479; rs17514774; rs17549832; rs17514563; rs35750720; rs36007443; rs17514494; rs35523548; rs17549825; rs17549720; rs6670146; rs17514788; rs17549636; rs5995; rs17514549; rs17514655; rs10577078; rs6672693; rs17514424; rs17549374; rs17514501; rs17549685; rs1759020; rs17549811; rs17549228; rs11438239; rs11450625; rs17549214; rs17514191; rs17514466; rs7411133; rs17549521; rs857022; rs17514459; rs12724830; rs17514843; rs10643350; rs17549527; rs17514473; rs17549507; rs34488858; rs35493286; rs41265223; rs17514830; rs10719375; rs34232043; rs34690792; rs10737685; rs12075161; rs12077334; rs12140782; rs12724676; rs1332668; rs1332669; rs1412639; rs2336595; rs6661664; rs6691224; rs6693887; rs6702252; rs7418993; rs7545829; rs7554881

# Metabolic_Enzyme_9_General_References:
2271707; 3021194; 2339067; 8324218; 10391209

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5943

# Metabolic_Enzyme_10_Name:
Glutamine synthetase

# Metabolic_Enzyme_10_Synonyms:
Glutamate--ammonia ligase; GS

# Metabolic_Enzyme_10_Gene_Name:
GLUL

# Metabolic_Enzyme_10_Protein_Sequence:
>Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN

# Metabolic_Enzyme_10_Number_of_Residues:
373

# Metabolic_Enzyme_10_Molecular_Weight:
42065

# Metabolic_Enzyme_10_Theoretical_pI:
6.88

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  acid-ammonia (or amide) ligase activity
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  glutamate-ammonia ligase activity
 ||
>>>
Process:  nitrogen compound metabolism
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  glutamine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_10_Pathway:
map00251  Glutamate metabolism;
 map00550  Peptidoglycan biosynthesis;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_10_Reaction:
ATP + L-glutamate + ammonia = ADP + phosphate + L-glutamine

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00120:Gln-synt_C;
PF03951:Gln-synt_N

# Metabolic_Enzyme_10_Signals:
None

# Metabolic_Enzyme_10_Transmembrane_Regions:
None

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 6.3.1.2

# Metabolic_Enzyme_10_GenBank_ID_Protein:
31833

# Metabolic_Enzyme_10_SwissProt_ID:
GLNA_HUMAN (P15104)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
GLUL

# Metabolic_Enzyme_10_Geneatlas_id:
GLUL

# Metabolic_Enzyme_10_hgnc_id:
HGNC:4341

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_10_Gene_Sequence:
>1122 bp
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA

# Metabolic_Enzyme_10_GenBank_ID_Gene:
Y00387

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_10_Locus:
1q31

# Metabolic_Enzyme_10_SNPs:
rs1058111; rs912900; rs9347; rs912901; rs4075941; rs4652704; rs7539686; rs7734; rs3895340; rs4652705; rs912902; rs12136955; rs12403634; rs4075940; rs1058788; rs16828882; rs8762; rs7543200; rs3795487; rs2296520; rs2296519; rs10494546; rs17462824; rs12735664; rs11577936; rs2296521; rs6691339; rs11577698; rs2296523; rs11577696; rs10797771; rs4652707; rs16858921; rs4652706; rs11585457; rs2296522; rs10429835; rs4517308; rs10797770; rs11541591; rs17855559; rs17852995; rs35378126; rs17852994; rs6666230; rs6684136; rs6679250; rs34809780; rs12082312; rs36115491; rs7548303; rs1058744; rs3199511; rs12757803; rs17509341; rs1058806; rs6703479; rs8527; rs1058719; rs10535077; rs4110992; rs6699943; rs35747237; rs35275813; rs35161314; rs35268520; rs10911069; rs10458354; rs34444584; rs34239448; rs12088820; rs3028837; rs35750497; rs1001403; rs10911070; rs10911071; rs11576932; rs12039934; rs12568730; rs12733426; rs12736387; rs12756106; rs17509572; rs17509621; rs1925829; rs2038891; rs2068781; rs2148030; rs4652708; rs6424853; rs6667958; rs6674281; rs6684297; rs6698722; rs7549329; rs7549498; rs7551829

# Metabolic_Enzyme_10_General_References:
2888076; 1681907; 7909780; 12387715

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5944

# Metabolic_Enzyme_11_Name:
L-serine dehydratase

# Metabolic_Enzyme_11_Synonyms:
L-serine deaminase

# Metabolic_Enzyme_11_Gene_Name:
SDS

# Metabolic_Enzyme_11_Protein_Sequence:
>Lserine dehydratase
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHF
VCSSAGNAGMAAAYAARQLGVPATIVVPGTTPALTIERLKNEGATCKVVGELLDEAFELA
KALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGL
QECGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGSQALKLFQEHP
IFSEVISDQEAVAAIEKFVDDEKILVEPAWGAALAAVYSHVIQKLQLEGNLRTPLPSLVV
IVCGGSNISLAQLRALKEQLGMTNRLPK

# Metabolic_Enzyme_11_Number_of_Residues:
328

# Metabolic_Enzyme_11_Molecular_Weight:
34703

# Metabolic_Enzyme_11_Theoretical_pI:
8.07

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
L-serine = pyruvate + NH(3)

# Metabolic_Enzyme_11_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00272  Cysteine metabolism

# Metabolic_Enzyme_11_Reaction:
L-serine = pyruvate + NH3

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00291:PALP

# Metabolic_Enzyme_11_Signals:
None

# Metabolic_Enzyme_11_Transmembrane_Regions:
None

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 4.3.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
338030

# Metabolic_Enzyme_11_SwissProt_ID:
SDHL_HUMAN (P20132)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
SDS

# Metabolic_Enzyme_11_Geneatlas_id:
SDS

# Metabolic_Enzyme_11_hgnc_id:
HGNC:10691

# Metabolic_Enzyme_11_PDB_ID:
1P5J

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_11_Gene_Sequence:
>987 bp
ATGATGTCTGGAGAACCCCTGCACGTGAAGACCCCCATCCGTGACAGCATGGCCCTGTCC
AAAATGGCCGGCACCAGCGTCTACCTCAAGATGGACAGTGCCCAGCCCTCCGGCTCCTTC
AAGATCCGGGGCATTGGGCACTTCTGCAAGAGGTGGGCCAAGCAAGGCTGTGCACATTTT
GTCTGCTCCTCGGCGGGCAACGCAGGCATGGCGGCTGCATATGCGGCCAGGCAACTCGGC
GTCCCCGCCACCATCGTAGTGCCCGGCACCACACCTGCTCTCACCATTGAGCGCCTCAAG
AATGAAGGTGCCACATGCAAGGTGGTGGGTGAGTTATTGGATGAAGCCTTCGAGCTGGCC
AAGGCCCTAGCGAAGAACAACCCGGGTTGGGTCTACATTCCCCCCTTTGATGACCCCCTC
ATCTGGGAAGGCCACGCTTCCATCGTGAAAGAGCTGAAGGAGACACTGTGGGAAAAGCCG
GGGGCCATCGCGCTGTCAGTGGGCGGCGGGGGCCTGCTGTGTGGAGTGGTCCAGGGGCTG
CAGGAGTGTGGCTGGGGGGACGTGCCTGTCATCGCCATGGAGACTTTTGGTGCCCACAGC
TTCCACGCTGCCACCACCGCAGGCAAACTTGTCTCCCTGCCCAAGATCACCAGTGTTGCC
AAGGCCCTGGGCGTGAAGACTGTGGGGTCTCAGGCCCTGAAGCTGTTTCAGGAACACCCC
ATTTTCTCTGAAGTTATCTCGGACCAGGAGGCTGTGGCCGCCATTGAGAAGTTCGTGGAT
GATGAGAAGATCCTGGTGGAGCCCGCCTGGGGCGCAGCCCTGGCCGCTGTCTATAGCCAC
GTGATCCAGAAGCTCCAACTGGAGGGGAATCTCCGAACCCCGCTGCCATCCCTCGTGGTC
ATCGTCTGCGGGGGCAGCAACATCAGCCTGGCCCAGCTGCGGGCGCTCAAGGAACAGCTG
GGCATGACAAATAGGTTGCCCAAGTGA

# Metabolic_Enzyme_11_GenBank_ID_Gene:
J05037

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_11_Locus:
12q24.13

# Metabolic_Enzyme_11_SNPs:
rs3812826; rs7960943; rs7980117; rs16942781; rs11609455; rs2069251; rs12820484; rs12832115; rs11829715; rs12833309; rs7135421; rs1050062; rs35465493; rs34607566; rs35638951; rs12306986; rs34954765; rs35429206; rs5800985; rs12824553; rs10624677; rs35911976; rs36075425; rs2303622; rs34218141; rs12824546; rs35764330; rs35270874; rs34219581; rs35190353; rs3794315; rs34550115; rs34835808; rs12766; rs7135290; rs13603; rs34921153; rs34099285; rs7135256; rs7135675; rs12304687; rs34839349; rs35942568; rs11420; rs34969035; rs34862362; rs34014624; rs11066549; rs11066552; rs11066553; rs11831414; rs11832103; rs12425042; rs12812648; rs12815112; rs12818674; rs34803330; rs35106464

# Metabolic_Enzyme_11_General_References:
2674117

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5595

# Metabolic_Enzyme_12_Name:
Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor

# Metabolic_Enzyme_12_Synonyms:
Carbamoyl-phosphate synthetase I; CPSase I

# Metabolic_Enzyme_12_Gene_Name:
CPS1

# Metabolic_Enzyme_12_Protein_Sequence:
>Carbamoylphosphate synthase ammonia, mitochondrial precursor
MTRILTAFKVVRTLKTGFGFTNVTAHQKWKFSRPGIRLLSVKAQTAHIVLEDGTKMKGYS
FGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNGGAPDTTALDELGLSKY
LESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVDTRMLTKIIRDKGTML
GKIEFEGQPVDFVDPNKQNLIAEVSTKDVKVYGKGNPTKVVAVDCGIKNNVIRLLVKRGA
EVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRKEPLFGISTGNLIT
GLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALDNTLPAGWKPLFVNVNDQT
NEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPKPALVASRV
EVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVGLKQAD
TVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES
IMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGIC
PNRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHT
GDSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLS
RSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDR
FHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRLPMNKEWPSNLDLR
KELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMT
EETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYV
TYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETV
STDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSP
LQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMN
VVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAG
VHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRA
SRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRD
ADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPRFLGVAEQ
LHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPSLSSIRKLIRDGSIDLVINLPN
NNTKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA


# Metabolic_Enzyme_12_Number_of_Residues:
1500

# Metabolic_Enzyme_12_Molecular_Weight:
164941

# Metabolic_Enzyme_12_Theoretical_pI:
6.71

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  carbamoyl-phosphate synthase activity
Function:  catalytic activity
 ||
>>>
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleobase metabolism
Process:  pyrimidine base metabolism
Process:  pyrimidine base biosynthesis
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_12_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

# Metabolic_Enzyme_12_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_12_Reaction:
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00289:CPSase_L_chain;
PF02786:CPSase_L_D2;
PF02787:CPSase_L_D3;
PF00988:CPSase_sm_chain;
PF00117:GATase;
PF02142:MGS

# Metabolic_Enzyme_12_Signals:
1-19

# Metabolic_Enzyme_12_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 6.3.4.16

# Metabolic_Enzyme_12_GenBank_ID_Protein:
219553

# Metabolic_Enzyme_12_SwissProt_ID:
CPSM_HUMAN (P31327)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
CPS1

# Metabolic_Enzyme_12_Geneatlas_id:
CPS1

# Metabolic_Enzyme_12_hgnc_id:
HGNC:2323

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_12_Gene_Sequence:
>4503 bp
ATGACGAGGATTTTGACAGCTTTCAAAGTGGTGAGGACACTGAAGACTGGTTTTGGCTTT
ACCAATGTGACTGCACACCAAAAATGGAAATTTTCAAGACCTGGCATCAGGCTCCTTTCT
GTCAAGGCACAGACAGCACACATTGTCCTGGAAGATGGAACTAAGATGAAAGGTTACTCC
TTTGGCCATCCATCCTCTGTTGCTGGTGAAGTGGTTTTTAATACTGGCCTGGGAGGGTAC
CCAGAAGCTATTACTGACCCTGCCTACAAAGGACAGATTCTCACAATGGCCAACCCTATT
ATTGGGAATGGTGGAGCTCCTGATACTACTTCTCTGGATGAACTGGGACTTAGCAAATAT
TTGGAGTCTAATGGAATCAAGGTTTCAGGTTTGCTGGTGCTGGATTATAGTAAAGACTAC
AACCACTGGCTGGCTACCAAGAGTTTAGGGCAATGGCTACAGGAAGAAAAGGTTCCTGCA
ATTTATGGAGTGGACACAAGAATGCTGACTAAAATAATTCGGGATAAGGGTACCATGCTT
GGGAAGATTGAATTTGAAGGTCAGCCTGTGGATTTTGTGGATCCAAATAAACAGAATTTG
ATTGCTGAGGTTTCAACCAAGGATGTCAAAGTGTACGGCAAAGGAAACCCCACAAAAGTG
GTAGCTGTAGACTGTGGGATTAAAAACAATGTAATCCGCCTGCTAGTAAAGCGAGGAGCT
GAAGTGCACTTAGTTCCCTGGAACCATGATTTCACCAAGATGGAGTATGATGGGATTTTG
ATCGCGGGAGGACCGGGGAACCCAGCTCTTGCAGAACCACTAATTCAGAATGTTCAGAAG
ATTTTGGAGAGTGATCGCAAGGAGCCATTGTTTGGAATCAGTACAGGAAACTTAATAACA
GGATTGGCTGCTGGTGCCAAAACCTACAAGATGTCCATGGCCAACAGAGGGCAGAATCAG
CCTGTTTTGAATATCACAAACAAACAGGCTTTCATTACTGCTCAGAATCATTGCTATGCC
TTGGACAACACCCTCCCTGCTGGCTGGAAACCACTTTTTGTGAATGTCAACGATCAAACA
AATGAGGGGATTATGCATGAGAGCAAACCCTTCTTCGCTGTGCAGTTCCACCCAGAGGTC
ACCCCGGGGCCAATAGACACTGAGTACCTGTTTGATTCCTTTTTCTCACTGATAAAGAAA
GGAAAAGCTACCACCATTACATCAGTCTTACCGAAGCCAGCACTAGTTGCATCTCGGGTT
GAGGTTTCCAAAGTCCTTATTCTAGGATCAGGAGGTCTGTCCATTGGTCAGGCTGGAGAA
TTTGATTACTCAGGATCTCAAGCTGTAAAAGCCATGAAGGAAGAAAATGTCAAAACTGTT
CTGATGAACCCAAACATTGCATCAGTCCAGACCAATGAGGTGGGCTTAAAGCAAGCGGAT
ACTGTCTACTTTCTTCCCATCACCCCTCAGTTTGTCACAGAGGTCATCAAGGCAGAACAG
CCAGATGGGTTAATTCTGGGCATGGGTGGCCAGACAGCTCTGAACTGTGGAGTAGAACTA
TTCAAGAGAGGTGTGCTCAAGGAATATGGTGTGAAAGTCCTGGGAACTTCAGTTGAGTCC
ATTATGGCTACGGAAGACAGGCAGCTGTTTTCAGATAAACTAAATGAGATCAATGAAAAG
ATTGCTCCAAGTTTTGCAGTGGAATCGATTGAGGATGCACTGAAGGCAGCAGACACCATT
GGCTACCCAGTGATGATCCGTTCCGCCTATGCACTGGGTGGGTTAGGCTCAGGCATCTGT
CCCAACAGAGAGACTTTGATGGACCTCAGCACAAAGGCCTTTGCTATGACCAACCAAATT
CTGGTGGAGAAGTCAGTGACAGGTTGGAAAGAAATAGAATATGAAGTGGTTCGAGATGCT
GATGACAATTGTGTCACTGTCTGTAACATGGAAAATGTTGATGCCATGGGTGTTCACACA
GGTGACTCAGTTGTTGTGGCTCCTGCCCAGACACTCTCCAATGCCGAGTTTCAGATGTTG
AGACGTACTTCAATCAATGTTGTTCGCCACTTGGGCATTGTGGGTGAATGCAACATTCAG
TTTGCCCTTCATCCTACCTCAATGGAATACTGCATCATTGAAGTGAATGCCAAGATGTCC
CCGAACTCTGCTCTGGCCTCCAAAACGACTGGCTACCCATTGGCATTCATTGCTGCAAAG
ATTGCCCTAGGAATCCCACTTCCAGGAATTAAGAACGTCGTATCCGGGAAGACATCAGCC
TGTTTTGAACCTAGCCTGGATTACATGGTCACCAAGATTCCCCGCTGGGATCTTGACCGT
TTTCATGGAACATCTAGCCGAATTGGTAGCTCTATGAAAAGTGTAGGAGAGGTCATGGCT
ATTGGTCGTACCTTTGAGGAGAGTTTCCAGAAAGCTTTACGGATGTGCCACCCATCTATA
GAGGGTTTCACTCCCCGTCTCCCAATGAACAAAGAATGGCCATCGAATTTAGATCTTAGA
AAAGAGTTGTCTGAACCAAGCAGCACGCGTATCTATGCCATTGCCAAGGCCATTGATGAC
AACATGTCCCTTGATGAGATTGAGAAGCTCACATACATTGACAAGTGGTTTTTGTATAAG
ATGCGTGATATTTTAAACATGGAAAAGACACTGAAAGGCCTCAACAGTGAGTCCATGACA
GAAGAAACCCTGAAAAGGGCAAAGGAGATTGGGTTCTCAGATAAGCAGATTTCAAAATGC
CTTGGGCTCACTGAGGCCCAGACAAGGGAGCTGAGGTTAAAGAAAAACATCCACCCTTGG
GTTAAACAGATTGATACACTGGCTGCAGAATACCCATCAGTAACAAACTATCTCTATGTT
ACCTACAATGGTCAGGAGCATGATGTCAATTTTGATGACCATGGAATGATGGTGCTAGGC
TGTGGTCCATATCACATTGGCAGCAGTGTGGAATTTGATTGGTGTGCTGTCTCTAGTATC
CGCACACTGCGTCAACTTGGCAAGAAGACGGTGGTGGTGAATTGCAATCCTGAGACTGTG
AGCACAGACTTTGATGAGTGTGACAAACTGTACTTTGAAGAGTTGTCCTTGGAGAGAATC
CTAGACATCTACCATCAGGAGGCATGTGGTGGCTGCATCATATCAGTTGGAGGCCAGATT
CCAAACAACCTGGCAGTTCCTCTATACAAGAATGGTGTCAAGATCATGGGCACAAGCCCC
CTGCAGATCGACAGGGCTGAGGATCGCTCCATCTTCTCAGCTGTCTTGGATGAGCTGAAG
GTGGCTCAGGCACCTTGGAAAGCTGTTAATACTTTGAATGAAGCACTGGAATTTGCAAAG
TCTGTGGACTACCCCTGCTTGTTGAGGCCTTCCTATGTTTTGAGTGGGTCTGCTATGAAT
GTGGTATTCTCTGAGGATGAGATGAAAAAATTCCTAGAAGAGGCGACTAGAGTTTCTCAG
GCCACGCCAGTGGTGCTGACAAAATTTGTTGAAGGGGCCCGAGAAGTAGAAATGGACGCT
GTTGGCAAAGATGGAAGGGTTATCTCTCATGCCATCTCTGAACATGTTGAAGATGCAGGT
GTCCACTCGGAGAATGCCACTCTGATGCTGCCCACACAAACCATCAGCCAAGGGGCCATT
GAAAAGGTGAAGGATGCTACCCGGAAGATTGCAAAGGCTTTTGCCATCTCTGGTCCATTC
AACGTCCAATTTCTTGTCAAAGGAAATGATGTCTTGGTGAATGAGTGTAACTTGAGAGCT
TCTCGATCCTTCCCCTCTGTTTCCAAGACTCTTGGGGTTGACTTCATTGATGTGGCCACC
AAGGTGTTGATTGGAGAGAATGTTGATGAGAAACATCTTCCAACATTGGACCATCCCATA
ATTCCTGTTGACTATGTTGCAATTAAGGCTCCCATGTTTTCCTGGCCCCGGTTGAGGGAT
GCTGACCCCATTCTGAGATGTGAGATGGCTTCCACTGGAGAGGTGGCTTGCTTTGGTGAA
GGTATTCATACAGCCTTCCTAAAGGCAATGCTTTCCACAGGATTTAAGATACCCCAGAAA
GGCATCCTGATAGGCATCCAGCAATCATTCCGGCCAAGATTCCTTGGTGTGGCTGAACAA
TTACACAATGAAGGTTTCAAGCTGTTTGCCACGGAAGCCACATCAGACTGGCTCAACGCC
AACAATGTCCCTGCCAACCCAGTGGCATGGCCGTCTCAAGAAGGACAGAATCCCAGCCTC
TCTTCCATCAGAAAATTGATTAGAGATGGCAGCATTGACCTAGTGATTAACCTTCCCAAC
AACAACACTAAATTTGTCCATGATAATTATGTGATTCGGAGGACAGCTGTTGATAGTGGA
ATCCCTCTCCTCACTAATTTTCAGGTGACCAAACTTTTTGCTGAAGCTGTGCAGAAATCT
CGCAAGGTGGACTCCAAGAGTCTTTTCCACTACAGGCAGTACAGTGCTGGAAAAGCAGCA
TAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
D90282

# Metabolic_Enzyme_12_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_12_Locus:
2q35

# Metabolic_Enzyme_12_SNPs:
rs7422339; rs1047883; rs2229589; rs34022862; rs35678745; rs715; rs10932349; rs7684; rs12476133; rs2371001; rs2371013; rs2371000; rs2287598; rs10932348; rs4399666; rs7572146; rs12694205; rs6721477; rs9789405; rs6435577; rs6750325; rs4356603; rs7576225; rs7583733; rs7598448; rs2302910; rs7599931; rs6435580; rs10804185; rs2302911; rs3821135; rs11903254; rs10932343; rs12694206; rs2287603; rs2370998; rs13429886; rs6714124; rs6748782; rs12468557; rs7422569; rs2287596; rs2302908; rs10165443; rs2277909; rs6724941; rs4233981; rs7607412; rs6734696; rs2371002; rs10184633; rs2370997; rs7573258; rs7606346; rs13028752; rs7568329; rs7587791; rs2302909; rs7583822; rs4142154; rs7607205; rs4672587; rs4312427; rs10179039; rs13416810; rs10515951; rs13415932; rs2371009; rs2287602; rs11684318; rs7599172; rs6744672; rs13005552; rs13005394; rs10176085; rs10469763; rs13010668; rs2887914; rs4420657; rs12694201; rs13010236; rs2371010; rs7588072; rs6749137; rs9288418; rs16844777; rs12694202; rs4325692; rs11681045; rs16844779; rs4567871; rs3213785; rs12997383; rs12694204; rs12466705; rs6755648; rs7558276; rs11886625; rs10932347; rs16844773; rs4614865; rs11686101; rs4309518; rs10804186; rs4396646; rs4673543; rs4673539; rs3213784; rs2287604; rs2371007; rs11895303; rs6726148; rs4640325; rs12616596; rs2371011; rs12694203; rs2270476; rs12991680; rs16844647; rs13033773; rs7567836; rs2370996; rs2371003; rs7601962; rs12615486; rs954499; rs16844683; rs7563093; rs16844781; rs12995914; rs17774535; rs10427333; rs7603980; rs16844718; rs6742717; rs6760497; rs11902281; rs7593211; rs7587942; rs10183104; rs13013076; rs10179212; rs16844641; rs17825928; rs7563009; rs17825520; rs33949976; rs13016856; rs2371005; rs13020941; rs10170142; rs16844788; rs951122; rs16844728; rs7606750; rs16844659; rs10211372; rs7575403; rs10932346; rs2287600; rs7598012; rs9752757; rs10191702; rs2371006; rs13391067; rs16844782; rs13416489; rs2371008; rs17773661; rs16844625; rs12990908; rs13401425; rs4363965; rs11889880; rs17832175; rs16844619; rs7587701; rs11897497; rs17824552; rs2302912; rs7575473; rs7580149; rs6743156; rs4673544; rs13399140; rs6754909; rs3770682; rs7582951; rs7575474; rs11685955; rs11680040; rs13383683; rs10180357; rs13022335; rs17775057; rs16844644; rs11685945; rs34222197; rs2887913; rs4142155; rs6749355; rs13388400; rs6749597; rs4433943; rs1047887; rs34656466; rs1129687; rs1047886; rs28940283; rs1129682; rs35374255; rs41272667; rs3835047; rs34778124; rs12475907; rs6728169; rs1048028; rs6743023; rs13017216; rs12996727; rs35985992; rs13409266; rs6435579; rs4257337; rs35940992; rs28429417; rs13385991; rs13429579; rs3217218; rs34201679; rs35410721; rs10195256; rs35896974; rs4673540; rs3214427; rs6720137; rs35440985; rs13414563; rs35586985; rs35809524; rs12992801; rs13431322; rs1060191; rs5838216; rs13031200; rs34987020; rs34054260; rs11902018; rs13429555; rs10427325; rs34903716; rs35104362; rs35072654; rs6717187; rs34665278; rs4673542; rs35548644; rs13393388; rs28469042; rs13024706; rs35354688; rs34484159; rs34713753; rs11269184; rs34922875; rs10182484; rs7607234; rs34394524; rs10525194; rs13408918; rs11315919; rs35970365; rs2270477; rs12988297; rs35299943; rs41272671; rs36066680; rs5838214; rs36093319; rs7568096; rs13035785; rs3217217; rs10715074; rs34542668; rs34056540; rs7562168; rs10203439; rs34919632; rs35523666; rs13017144; rs34134708; rs34869171; rs35129622; rs41272673; rs5838212; rs11372499; rs13432514; rs4989049; rs6704874; rs34800242; rs3213783; rs13017275; rs11321061; rs34710033; rs883542; rs35087298; rs4482415; rs16844626; rs7601865; rs4297818; rs34449727; rs35898556; rs3060402; rs34972394; rs35369959; rs34299015; rs5838213; rs41272669; rs5838215; rs6743099; rs12993913; rs16844749; rs4673541; rs36106186; rs4450537; rs13025458; rs7580590; rs2371012; rs11384554; rs28499505; rs36071800; rs4490117; rs35175269; rs34676314; rs2287597; rs4672585; rs2370999; rs12998821; rs34972928; rs13409263; rs13017341; rs6712334; rs35672393; rs34291327; rs13027714; rs10167325; rs17831707; rs3217219; rs34976026; rs36067265; rs13409110; rs34983401; rs34829607; rs3060429; rs12998416; rs35010546; rs13391585; rs34287343; rs41272665; rs13396451; rs34334217; rs6435578; rs11372498; rs35833900; rs4482413; rs35170724; rs11340188; rs6721139; rs13411696; rs35644063; rs34228696; rs6732642; rs10654573; rs3060397; rs10172081; rs10192215; rs10194936; rs10932345; rs11887861; rs11903219; rs12475210; rs12620917; rs12623361; rs13386028; rs13386056; rs16844800; rs17773128; rs17775871; rs2287599; rs2371014; rs2371015; rs2371017; rs2544304; rs2664230; rs35863145; rs3770683; rs3770684; rs4142151; rs4142152; rs4142153; rs4672588; rs5002316; rs5009272; rs6727826; rs6752652; rs7571548; rs7572869; rs9288420

# Metabolic_Enzyme_12_General_References:
1840546; 9711878; 12955727; 11474210

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5393

# Metabolic_Enzyme_13_Name:
Amine oxidase [flavin-containing] B

# Metabolic_Enzyme_13_Synonyms:
Monoamine oxidase type B; MAO-B

# Metabolic_Enzyme_13_Gene_Name:
MAOB

# Metabolic_Enzyme_13_Protein_Sequence:
>Amine oxidase flavincontaining 
BMSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGS
YVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFW
RTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHE
VSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYID
QTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIV
YYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEE
RLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVD
RIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITT
TFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

# Metabolic_Enzyme_13_Number_of_Residues:
520

# Metabolic_Enzyme_13_Molecular_Weight:
58764

# Metabolic_Enzyme_13_Theoretical_pI:
7.55

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

# Metabolic_Enzyme_13_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_13_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_13_Signals:
None

# Metabolic_Enzyme_13_Transmembrane_Regions:
490-516

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_13_GenBank_ID_Protein:
398415

# Metabolic_Enzyme_13_SwissProt_ID:
AOFB_HUMAN (P27338)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
MAOB

# Metabolic_Enzyme_13_Geneatlas_id:
MAOB

# Metabolic_Enzyme_13_hgnc_id:
HGNC:6834

# Metabolic_Enzyme_13_PDB_ID:
2BK3

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_13_Gene_Sequence:
>1560 bp
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC


# Metabolic_Enzyme_13_GenBank_ID_Gene:
S62734

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_13_Locus:
Xp11.23

# Metabolic_Enzyme_13_SNPs:
rs7879356; rs6324; rs12010260; rs2072745; rs17462; rs3027440; rs7066677; rs3027439; rs1799836; rs3027453; rs2311013; rs3027441; rs5905512; rs3027459; rs2239450; rs2239441; rs7890174; rs5952297; rs3027444; rs5952330; rs7883073; rs5952671; rs6520902; rs2239449; rs6651806; rs3027454; rs7057075; rs12394221; rs2238969; rs12008119; rs7888450; rs12388038; rs2283727; rs12013965; rs17310637; rs12008438; rs5952294; rs5952340; rs12008548; rs12014398; rs1014876; rs3027449; rs2283730; rs2283729; rs5952813; rs6520901; rs5952352; rs2205655; rs10521432; rs6610856; rs12006628; rs3027450; rs6610853; rs2283731; rs3027456; rs2283728; rs9887326; rs5952325; rs3027442; rs7879586; rs12389168; rs3817729; rs12851487; rs5952686; rs3736672; rs2056913; rs1569424; rs7053203; rs2092042; rs7876594; rs12010996; rs3027457; rs9887047; rs3027451; rs17146716; rs7061798; rs3027464; rs6609259; rs3027446; rs736944; rs2239442; rs6609260; rs7067187; rs3027466; rs12558324; rs7888462; rs3027452; rs2092040; rs4824562; rs17146721; rs7884044; rs3027461; rs12389234; rs12007768; rs17244906; rs5952795; rs17146719; rs5905449; rs5952799; rs12394863; rs3027458; rs3027443; rs9698576; rs2092041; rs7892217; rs7061088; rs12689868; rs7067027; rs3027448; rs12558614; rs7057957; rs1040398; rs1040400; rs3027435; rs1181252; rs1040399; rs3027434; rs17852046; rs12850496; rs12845773; rs17856663; rs12845783; rs5952696; rs3191382; rs1181251; rs35285191; rs1051000; rs1803940; rs3027438; rs1051003; rs1050990; rs4339787; rs28530533; rs3027468; rs5952754; rs5952690; rs12558961; rs12852985; rs34468176; rs2311012; rs5905428; rs34165496; rs34825602; rs7892394; rs5952812; rs11091124; rs5906017; rs28522648; rs5952677; rs11282093; rs5906045; rs3838196; rs3027455; rs28667959; rs3027463; rs35676271; rs12841775; rs35574902; rs3027447; rs28657720; rs6610848; rs28531879; rs4824563; rs6610854; rs7060566; rs12396954; rs3027469; rs35687186; rs5952736; rs35375952; rs7057164; rs34716997; rs7062993; rs7063171; rs11412800; rs6651629; rs12845848; rs12853563; rs12012179; rs28368734; rs12115950; rs35968321; rs3027460; rs12394356; rs35439218; rs36085366; rs34265248; rs35762562; rs2239451; rs34292051; rs3027445; rs11320541; rs10481834; rs12845568; rs4592179; rs3216388; rs34945383; rs34220802; rs6610855; rs34261731; rs28485908; rs7888867; rs11431011; rs4071606; rs12390352; rs10567219; rs35520175; rs28527225; rs36068670; rs5952687; rs7888857; rs5952777; rs34822523; rs12010683; rs7883563; rs5952814; rs36209687; rs5952751; rs2238970; rs5952744; rs35797631; rs12389578; rs7474005; rs3027465; rs5952768; rs5906031; rs28636832; rs34252524; rs7058426; rs12391346; rs12689072; rs35943983; rs12395246; rs11414517; rs3027467; rs12013925; rs3736671; rs28421767; rs7058949; rs35634965; rs28754429; rs1894610; rs36102775; rs9887081; rs5952817; rs12855578; rs10658111; rs7062575; rs4620438; rs28568938; rs35291347; rs11797733; rs35054600; rs5952335; rs3027462; rs5952712; rs34752122; rs3054011; rs3027437; rs28577261; rs3027433; rs3761584; rs3027436; rs3027432; rs12558036; rs3027418; rs3027419; rs3027420; rs3027421; rs3027423; rs3027424; rs3027425; rs3027426; rs3027427; rs3027428; rs3027429; rs3027430; rs3027431; rs4351544; rs7884135; rs7890899

# Metabolic_Enzyme_13_General_References:
2023912; 3387449; 8515265; 1432104; 11049757; 11753429

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5401

# Metabolic_Enzyme_14_Name:
Amine oxidase [flavin-containing] A

# Metabolic_Enzyme_14_Synonyms:
Monoamine oxidase type A; MAO-A

# Metabolic_Enzyme_14_Gene_Name:
MAOA

# Metabolic_Enzyme_14_Protein_Sequence:
>Amine oxidase flavincontaining 
AMENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEH
VDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPI
AYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVN
INVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVK
LNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLP
MGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQY
GRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESK
DVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

# Metabolic_Enzyme_14_Number_of_Residues:
527

# Metabolic_Enzyme_14_Molecular_Weight:
59682

# Metabolic_Enzyme_14_Theoretical_pI:
7.96

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_14_Specific_Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

# Metabolic_Enzyme_14_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism

# Metabolic_Enzyme_14_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF01593:Amino_oxidase

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
498-518

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.4.3.4

# Metabolic_Enzyme_14_GenBank_ID_Protein:
187353

# Metabolic_Enzyme_14_SwissProt_ID:
AOFA_HUMAN (P21397)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
MAOA

# Metabolic_Enzyme_14_Geneatlas_id:
MAOA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:6833

# Metabolic_Enzyme_14_PDB_ID:
1O5W

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Mitochondrion; mitochondrial outer membrane; single-pass type IV membrane protein; cytoplasmic side

# Metabolic_Enzyme_14_Gene_Sequence:
>1584 bp
ATGGAGAATCAAGAGAAGGCGAGTATCGCGGGCCACATGTTCGACGTAGTCGTGATCGGA
GGTGGCATTTCAGGACTATCTGCTGCCAAACTCTTGACTGAATATGGCGTTAGTGTTTTG
GTTTTAGAAGCTCGGGACAGGGTTGGAGGAAGAACATATACTATAAGGAATGAGCATGTT
GATTACGTAGATGTTGGTGGAGCTTATGTGGGACCAACCCAAAACAGAATCTTACGCTTG
TCTAAGGAGCTGGGCATAGAGACTTACAAAGTGAATGTCAGTGAGCGTCTCGTTCAATAT
GTCAAGGGGAAAACATATCCATTTCGGGGCGCCTTTCCACCAGTATGGAATCCCATTGCA
TATTTGGATTACAATAATCTGTGGAGGACAATAGATAACATGGGGAAGGAGATTCCAACT
GATGCACCCTGGGAGGCTCAACATGCTGACAAATGGGACAAAATGACCATGAAAGAGCTC
ATTGACAAAATCTGCTGGACAAAGACTGCTAGGCGGTTTGCTTATCTTTTTGTGAATATC
AATGTGACCTCTGAGCCTCACGAAGTGTCTGCCCTGTGGTTCTTGTGGTATGTGAAGCAG
TGCGGGGGCACCACTCGGATATTCTCTGTCACCAATGGTGGCCAGGAACGGAAGTTTGTA
GGTGGATCTGGTCAAGTGAGCGAACGGATAATGGACCTCCTCGGAGACCAAGTGAAGCTG
AACCATCCTGTCACTCACGTTGACCAGTCAAGTGACAACATCATCATAGAGACGCTGAAC
CATGAACATTATGAGTGCAAATACGTAATTAATGCGATCCCTCCGACCTTGACTGCCAAG
ATTCACTTCAGACCAGAGCTTCCAGCAGAGAGAAACCAGTTAATTCAGCGGCTTCCAATG
GGAGCTGTCATTAAGTGCATGATGTATTACAAGGAGGCCTTCTGGAAGAAGAAGGATTAC
TGTGGCTGCATGATCATTGAAGATGAAGATGCTCCAATTTCAATAACCTTGGATGACACC
AAGCCTGATGGGTCACTGCCTGCCATCATGGGCTTCATTCTTGCCCGGAAAGCTGATCGA
CTTGCTAAGCTACATAAGGAAATAAGGAAGAAGAAAATCTGTGAGCTCTATGCCAAAGTG
CTGGGATCCCAAGAAGCTTTACATCCAGTGCATTATGAAGAGAAGAACTGGTGTGAGGAG
CAGTACTCTGGGGGCTGCTACACGGCCTACTTCCCTCCTGGGATCATGACTCAATATGGA
AGGGTGATTCGTCAACCCGTGGGCAGGATTTTCTTTGCGGGCACAGAGACTGCCACAAAG
TGGAGCGGCTACATGGAAGGGGCAGTTGAGGCTGGAGAACGAGCAGCTAGGGAGGTCTTA
AATGGTCTCGGGAAGGTGACCGAGAAAGATATCTGGGTACAAGAACCTGAATCAAAGGAC
GTTCCAGCGGTAGAAATCACCCACACCTTCTGGGAAAGGAACCTGCCCTCTGTTTCTGGC
CTGCTGAAGATCATTGGATTTTCCACATCAGTAACTGCCCTGGGGTTTGTGCTGTACAAA
TACAAGCTCCTGCCACGGTCTTGA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
M68840

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:X

# Metabolic_Enzyme_14_Locus:
Xp11.3

# Metabolic_Enzyme_14_SNPs:
rs6323; rs1137070; rs1800464; rs3027407; rs2072743; rs1465107; rs979605; rs3027397; rs2205718; rs979606; rs909525; rs3788862; rs2283725; rs2235186; rs5906883; rs5906974; rs3027403; rs3027405; rs6520894; rs3027401; rs3788863; rs2235185; rs1465108; rs5953385; rs2310883; rs6609250; rs3027398; rs5906938; rs5906729; rs6520897; rs5906893; rs17146683; rs7885398; rs3027402; rs5905702; rs5906957; rs2072744; rs5906915; rs4824498; rs9723729; rs3027406; rs5906973; rs3027400; rs2064697; rs5906914; rs5906901; rs12689575; rs2239448; rs2064696; rs3027392; rs2238968; rs17146660; rs12688067; rs9723711; rs7051042; rs5905859; rs7887158; rs2064698; rs7882699; rs3027399; rs9330645; rs2283724; rs9723795; rs3027404; rs9724332; rs5953210; rs1803986; rs1799835; rs1800466; rs1803987; rs1800465; rs7065428; rs3027408; rs11544798; rs12839550; rs10545588; rs5952250; rs3027394; rs34390290; rs1800659; rs10560402; rs12854463; rs35759188; rs28375424; rs7059300; rs12687961; rs35784967; rs35254233; rs34894015; rs35215664; rs35546327; rs3027396; rs12556694; rs7057038; rs12687974; rs9780693; rs7892282; rs5902323; rs28593700; rs35600375; rs35488042; rs35200424; rs5902326; rs5905823; rs12843650; rs34941362; rs34841794; rs12833632; rs12863636; rs3030071; rs12398290; rs10548364; rs28401570; rs4604608; rs28449781; rs6609256; rs6610845; rs12833929; rs12843268; rs2310884; rs5905830; rs6610846; rs7054032; rs7880230; rs41303697; rs3810709; rs2179098; rs12399572; rs12840448; rs5902324; rs28556796; rs5905812; rs12847449; rs28619059; rs10652560; rs6610837; rs10548363; rs5905418; rs2283726; rs33910552; rs3027395; rs28637527; rs5906971; rs28439389; rs35235270; rs3027393; rs28583596; rs6610842; rs6520893; rs35336176; rs5906913; rs12849959; rs36036121; rs5905822; rs5902325; rs5905809; rs11471949; rs6610834; rs3838195; rs3216387; rs33946653; rs6609255; rs35445276; rs7061874; rs17436054; rs1181275; rs12843533; rs2064070; rs3027409; rs3027410; rs3027414; rs3027415; rs3027416; rs3027417; rs4301558; rs4570308; rs5905613; rs6609257; rs6609258; rs7052785; rs727884

# Metabolic_Enzyme_14_General_References:
3418353; 3387449; 1432104; 8584674; 7519662; 3178846; 2764901; 11812236

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5945

# Metabolic_Enzyme_15_Name:
Coagulation factor XIII A chain precursor

# Metabolic_Enzyme_15_Synonyms:
Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain

# Metabolic_Enzyme_15_Gene_Name:
F13A1

# Metabolic_Enzyme_15_Protein_Sequence:
>Coagulation factor XIII A chain precursor
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM

# Metabolic_Enzyme_15_Number_of_Residues:
732

# Metabolic_Enzyme_15_Molecular_Weight:
83268

# Metabolic_Enzyme_15_Theoretical_pI:
5.95

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Not Available

# Metabolic_Enzyme_15_Specific_Function:
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin

# Metabolic_Enzyme_15_Pathway:
Not Available

# Metabolic_Enzyme_15_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_15_Signals:
None

# Metabolic_Enzyme_15_Transmembrane_Regions:
None

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_15_GenBank_ID_Protein:
182309

# Metabolic_Enzyme_15_SwissProt_ID:
F13A_HUMAN (P00488)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
F13A1

# Metabolic_Enzyme_15_Geneatlas_id:
F13A1

# Metabolic_Enzyme_15_hgnc_id:
HGNC:3531

# Metabolic_Enzyme_15_PDB_ID:
1FIE

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Cytoplasm. Secreted protein. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma

# Metabolic_Enzyme_15_Gene_Sequence:
>2199 bp
ATGTCAGAAACTTCCAGGACCGCCTTTGGAGGCAGAAGAGCAGTTCCACCCAATAACTCT
AATGCAGCGGAAGATGACCTGCCCACAGTGGAGCTTCAGGGCGTGGTGCCCCGGGGCGTC
AACCTGCAAGAGTTTCTTAATGTCACGAGCGTTCACCTGTTCAAGGAGAGATGGGACACT
AACAAGGTGGACCACCACACTGACAAGTATGAAAACAACAAGCTGATTGTCCGCAGAGGG
CAGTCTTTCTATGTGCAGATTGACTTCAGTCGTCCATATGACCCCAGAAGGGATCTCTTC
AGGGTGGAATACGTCATTGGTCGCTACCCACAGGAGAACAAGGGAACCTACATCCCAGTG
CCTATAGTCTCAGAGTTACAAAGTGGAAAGTGGGGGGCCAAGATTGTCATGAGAGAGGAC
AGGTCTGTGCGGCTGTCCATCCAGTCTTCCCCCAAATGTATTGTGGGGAAATTCCGCATG
TATGTTGCTGTCTGGACTCCCTATGGCGTACTTCGAACCAGTCGAAACCCAGAAACAGAC
ACGTACATTCTCTTCAATCCTTGGTGTGAAGATGATGCTGTGTATCTGGACAATGAGAAA
GAAAGAGAAGAGTATGTCCTGAATGACATCGGGGTAATTTTTTATGGAGAGGTCAATGAC
ATCAAGACCAGAAGCTGGAGCTATGGTCAGTTTGAAGATGGCATCCTGGACACTTGCCTG
TATGTGATGGACAGAGCACAAATGGACCTCTCTGGAAGAGGGAATCCCATCAAAGTCAGC
CGTGTGGGGTCTGCAATGGTGAATGCCAAAGATGACGAAGGTGTCCTCGTTGGATCCTGG
GACAATATCTATGCCTATGGCGTCCCCCCATCGGCCTGGACTGGAAGCGTTGACATTCTA
TTGGAATACCGGAGCTCTGAGAATCCAGTCCGGTATGGCCAATGCTGGGTTTTTGCTGGT
GTCTTTAACACATTTTTACGATGCCTTGGAATACCAGCAAGAATTGTTACCAATTATTTC
TCTGCCCATGATAATGATGCCAATTTGCAAATGGACATCTTCCTGGAAGAAGATGGGAAC
GTGAATTCCAAACTCACCAAGGATTCAGTGTGGAACTACCACTGCTGGAATGAAGCATGG
ATGACAAGGCCTGACCTTCCTGTTGGATTTGGAGGCTGGCAAGCTGTGGACAGCACCCCC
CAGGAAAATAGCGATGGCATGTATCGGTGTGGCCCCGCCTCGGTTCAAGCCATCAAGCAC
GGCCATGTCTGCTTCCAATTTGATGCACCTTTTGTTTTTGCAGAGGTCAACAGCGACCTC
ATTTACATTACAGCTAAGAAAGATGGCACTCATGTGGTGGAAAATGTGGATGCCACCCAC
ATTGGGAAATTAATTGTGACCAAACAAATTGGAGGAGATGGCATGATGGATATTACTGAT
ACTTACAAATTCCAAGAAGGTCAAGAAGAAGAGAGATTGGCCCTAGAAACTGCCCTGATG
TACGGAGCTAAAAAGCCCCTCAACACAGAAGGTGTCATGAAATCAAGGTCCAACGTTGAC
ATGGACTTTGAAGTGGAAAATGCTGTGCTGGGAAAAGACTTCAAGCTCTCCATCACCTTC
CGGAACAACAGCCACAACCGTTACACCATCACAGCTTATCTCTCAGCCAACATCACCTTC
TACACCGGGGTCCTGAAGGCAGAATTCAAGAAGGAGACGTTCGACGTGACGCTGGAGCCC
TTGTCCTTCAAGAAAGAGGCGGTGCTGATCCAAGCCGGCGAGTACATGGGTCAGCTGCTG
GAACAAGCGTCCCTGCACTTCTTTGTCACAGCTCGCATCAATGAGACCAGGGATGTTCTG
GCCAAGCAAAAGTCCACCGTGCTAACCATCCCTGAGATCATCATCAAGGTCCGTGGCACT
CAGGTAGTTGGTTCTGACATGACTGTGACAGTTCAGTTTACCAATCCTTTAAAAGAAACC
CTGCGAAATGTCTGGGTACACCTGGATGGTCCTGGAGTAACAAGACCAATGAAGAAGATG
TTCCGTGAAATCCGGCCCAACTCCACCGTGCAGTGGGAAGAAGTGTGCCGGCCCTGGGTC
TCTGGGCATCGGAAGCTGATAGCCAGCATGAGCAGTGACTCCCTGAGACATGTGTATGGC
GAGCTGGACGTGCAGATTCAAAGACGACCTTCCATGTGA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
M22001

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_15_Locus:
6p25.3-p24.3

# Metabolic_Enzyme_15_SNPs:
Not Available

# Metabolic_Enzyme_15_General_References:
2901091; 3026437; 2877457; 2877456; 4811064; 7913750; 7660355; 9515726; 9988734; 7913909; 1353995; 9763561; 10391209

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5946

# Metabolic_Enzyme_16_Name:
Protein-arginine deiminase type-4

# Metabolic_Enzyme_16_Synonyms:
Protein-arginine deiminase type IV; Peptidylarginine deiminase IV; HL-60 PAD

# Metabolic_Enzyme_16_Gene_Name:
PADI4

# Metabolic_Enzyme_16_Protein_Sequence:
>Proteinarginine deiminase type4
MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHSPPAKK
KSTGSSTWPLDPGVEVTLTMKAASGSTGDQKVQISYYGPKTPPVKALLYLTAVEISLCAD
ITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDM
SLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMV
PGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTP
NTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAP
HKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRG
KEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVP
APDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNS
FVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPK
PFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWN
MVP

# Metabolic_Enzyme_16_Number_of_Residues:
663

# Metabolic_Enzyme_16_Molecular_Weight:
74096

# Metabolic_Enzyme_16_Theoretical_pI:
6.56

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Not Available

# Metabolic_Enzyme_16_Specific_Function:
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1

# Metabolic_Enzyme_16_Pathway:
Not Available

# Metabolic_Enzyme_16_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_16_Signals:
None

# Metabolic_Enzyme_16_Transmembrane_Regions:
None

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_16_GenBank_ID_Protein:
5913971

# Metabolic_Enzyme_16_SwissProt_ID:
PADI4_HUMAN (Q9UM07)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
PADI4

# Metabolic_Enzyme_16_Geneatlas_id:
PADI4

# Metabolic_Enzyme_16_hgnc_id:
HGNC:18368

# Metabolic_Enzyme_16_PDB_ID:
1WD8

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Cytoplasm. Nucleus. Note=Cytoplasmic granules of eosinophils and neutrophils

# Metabolic_Enzyme_16_Gene_Sequence:
>1992 bp
ATGGCCCAGGGGACATTGATCCGTGTGACCCCAGAGCAGCCCACCCATGCCGTGTGTGTG
CTGGGCACCTTGACTCAGCTTGACATCTGCAGCTCTGCCCCTGAGGACTGCACGTCCTTC
AGCATCAACGCCTCCCCAGGGGTGGTCGTGGATATTGCCCACAGCCCTCCAGCCAAGAAG
AAATCCACAGGTTCCTCCACATGGCCCCTGGACCCTGGGGTAGAGGTGACCCTGACGATG
AAAGCGGCCAGTGGTAGCACAGGCGACCAGAAGGTTCAGATTTCATACTACGGACCCAAG
ACTCCACCAGTCAAAGCTCTACTCTACCTCACCGCGGTGGAAATCTCCCTGTGCGCAGAC
ATCACCCGCACCGGCAAAGTGAAGCCAACCAGAGCTGTGAAAGATCAGAGGACCTGGACC
TGGGGCCCTTGTGGACAGGGTGCCATCCTGCTGGTGAACTGTGACAGAGACAATCTCGAA
TCTTCTGCCATGGACTGCGAGGATGATGAAGTGCTTGACAGCGAAGACCTGCAGGACATG
TCGCTGATGACCCTGAGCACGAAGACCCCCAAGGACTTCTTCACAAACCATACACTGGTG
CTCCACGTGGCCAGGTCTGAGATGGACAAAGTGAGGGTGTTTCAGGCCACACGGGGCAAA
CTGTCCTCCAAGTGCAGCGTAGTCTTGGGTCCCAAGTGGCCCTCTCACTACCTGATGGTC
CCCGGTGGAAAGCACAACATGGACTTCTACGTGGAGGCCCTCGCTTTCCCGGACACCGAC
TTCCCGGGGCTCATTACCCTCACCATCTCCCTGCTGGACACGTCCAACCTGGAGCTCCCC
GAGGCTGTGGTGTTCCAAGACAGCGTGGTCTTCCGCGTGGCGCCCTGGATCATGACCCCC
AACACCCAGCCCCCGCAGGAGGTGTACGCGTGCAGTATTTTTGAAAATGAGGACTTCCTG
AAGTCAGTGACTACTCTGGCCATGAAAGCCAAGTGCAAGCTGACCATCTGCCCTGAGGAG
GAGAACATGGATGACCAGTGGATGCAGGATGAAATGGAGATCGGCTACATCCAAGCCCCA
CACAAAACGCTGCCCGTGGTCTTCGACTCTCCAAGGAACAGAGGCCTGAAGGAGTTTCCC
ATCAAACGAGTGATGGGTCCAGATTTTGGCTATGTAACTCGAGGGCCCCAAACAGGGGGT
ATCAGTGGACTGGACTCCTTTGGGAACCTGGAAGTGAGCCCCCCAGTCACAGTCAGGGGC
AAGGAATACCCGCTGGGCAGGATTCTCTTCGGGGACAGCTGTTATCCCAGCAATGACAGC
CGGCAGATGCACCAGGCCCTGCAGGACTTCCTCAGTGCCCAGCAGGTGCAGGCCCCTGTG
AAGCTCTATTCTGACTGGCTGTCCGTGGGCCACGTGGACGAGTTCCTGAGCTTTGTGCCA
GCACCCGACAGGAAGGGCTTCCGGCTGCTCCTGGCCAGCCCCAGGTCCTGCTACAAACTG
TTCCAGGAGCAGCAGAATGAGGGCCACGGGGAGGCCCTGCTGTTCGAAGGGATCAAGAAA
AAAAAACAGCAGAAAATAAAGAACATTCTGTCAAACAAGACATTGAGAGAACATAATTCA
TTTGTGGAGAGATGCATCGACTGGAACCGCGAGCTGCTGAAGCGGGAGCTGGGCCTGGCC
GAGAGTGACATCATTGACATCCCGCAGCTCTTCAAGCTCAAAGAGTTCTCTAAGGCGGAA
GCTTTTTTCCCCAACATGGTGAACATGCTGGTGCTAGGGAAGCACCTGGGCATCCCCAAG
CCCTTCGGGCCCGTCATCAACGGCCGCTGCTGCCTGGAGGAGAAGGTGTGTTCCCTGCTG
GAGCCACTGGGCCTCCAGTGCACCTTCATCAACGACTTCTTCACCTACCACATCAGGCAT
GGGGAGGTGCACTGCGGCACCAACGTGCGCAGAAAGCCCTTCTCCTTCAAGTGGTGGAAC
ATGGTGCCCTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
AB017919

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_16_Locus:
1p36.13

# Metabolic_Enzyme_16_SNPs:
rs1748020; rs11588132; rs11203366; rs11203367; rs874881; rs35809521; rs35381732; rs35903413; rs33981382; rs12733102; rs16825565; rs1748033; rs2240335; rs2301887; rs2477152; rs1635561; rs2501806; rs1635580; rs2147333; rs2240336; rs2477131; rs1635571; rs1635594; rs1548323; rs2240337; rs1748031; rs1621005; rs11203354; rs766449; rs2147332; rs6673715; rs1886301; rs1635597; rs1748035; rs942460; rs882537; rs4920591; rs10888018; rs6673392; rs1748032; rs1924552; rs1748034; rs1635577; rs1555658; rs3795214; rs4920594; rs1886302; rs10788664; rs874882; rs1635565; rs1204895; rs1408424; rs1635586; rs1359303; rs1635592; rs1748038; rs4506507; rs7534455; rs2477129; rs6586526; rs11581515; rs2240338; rs12754590; rs10888017; rs1748028; rs12030939; rs1635583; rs1748015; rs4920600; rs1635584; rs1635567; rs1635579; rs10888020; rs10788662; rs2428736; rs11203359; rs6586520; rs11203360; rs3795213; rs1635593; rs1612843; rs2501808; rs1635590; rs2301888; rs2428735; rs10888023; rs11585797; rs4450060; rs2501801; rs1635578; rs1886300; rs1748030; rs12033604; rs1613229; rs1748021; rs11578027; rs16825533; rs1748039; rs1635591; rs2501804; rs11203361; rs4920601; rs10888019; rs1635596; rs1748027; rs6683201; rs11203358; rs1635570; rs1748029; rs10888024; rs11203368; rs1635564; rs2240339; rs4920598; rs6692262; rs4920592; rs1957879; rs1635574; rs1748025; rs11203370; rs1957880; rs10888021; rs1748022; rs1748041; rs1748014; rs1748036; rs4345840; rs12136589; rs7417937; rs2240340; rs3094881; rs2501799; rs12408893; rs11203363; rs6683037; rs11585594; rs3094882; rs4920363; rs1635576; rs12124732; rs1748011; rs12758919; rs12746451; rs11203356; rs4920597; rs1635599; rs11203362; rs11587827; rs1635569; rs1613767; rs10788666; rs1748023; rs1957878; rs12752914; rs6662651; rs9970772; rs12731545; rs4920595; rs10788665; rs6686220; rs1748010; rs1635589; rs11203369; rs4920368; rs11803423; rs12757498; rs1635595; rs12746252; rs11203371; rs1635587; rs10788663; rs10888022; rs6673924; rs12035527; rs1635566; rs1748040; rs4920593; rs13375202; rs1204893; rs12045971; rs12035646; rs1635598; rs6687815; rs2352842; rs1635585; rs1748013; rs2501803; rs11583124; rs11203364; rs2477130; rs1204894; rs12741565; rs2501798; rs4920596; rs34481461; rs11203365; rs12074670; rs2501800; rs6686575; rs12037914; rs12754450; rs1957881; rs1635581; rs10749618; rs12739518; rs1748012; rs2501807; rs11576537; rs1635588; rs16825849; rs11203357; rs3795212; rs1748019; rs11586805; rs12725408; rs4920370; rs11203355; rs1408422; rs11579504; rs2501795; rs1408423; rs2477134; rs2477133; rs2501796; rs2501797; rs34743635; rs34309058; rs41265997; rs41265995; rs17852287; rs2301886; rs35240185; rs34954650; rs28615821; rs35598859; rs35489932; rs12730340; rs34915552; rs34438787; rs35921803; rs12131500; rs7554069; rs7546502; rs35758312; rs34160027; rs4920366; rs4920367; rs34016518; rs12082954; rs1748017; rs2501802; rs12752201; rs34170018; rs12083954; rs12568981; rs34916684; rs12731357; rs10716965; rs11378800; rs12083961; rs34285885; rs12035959; rs28758219; rs11464953; rs7543168; rs34470277; rs12034419; rs34385095; rs7520664; rs1635572; rs6673284; rs3795215; rs41266005; rs35236764; rs12405468; rs1635568; rs11203372; rs9699928; rs34232443; rs12746706; rs34298414; rs12089685; rs1635582; rs1635562; rs35385422; rs12217055; rs41266003; rs12743026; rs34576251; rs6664430; rs2477150; rs12036010; rs1635575; rs1748037; rs11344957; rs35095098; rs4920599; rs34199675; rs35943476; rs11802787; rs34213328; rs35076930; rs35658272; rs12042078; rs34897407; rs35025070; rs12737739; rs12039455; rs35326089; rs35023063; rs2477132; rs1635573; rs12568975; rs12567171; rs34686723; rs11403728; rs35210719; rs7520570; rs12082953; rs4506506; rs1748016; rs12569317; rs11578712; rs6698443; rs12754248; rs34742148; rs35581887; rs12042081; rs10667653; rs36072593; rs34677561; rs35348318; rs28868072; rs36164094; rs35695252; rs35412937; rs12405467; rs34957305; rs10437048; rs2477151; rs34960180; rs10693700; rs34632931; rs11327771; rs34965359; rs35072789; rs11372157; rs34965564; rs36097026; rs13376691; rs11421885; rs35287029; rs12038068; rs12731347; rs28639685; rs34581837; rs2501805; rs7520668; rs36096227; rs12042956; rs11586295; rs1748024; rs1635563; rs34852999; rs7545194; rs11364408; rs35809798; rs35644008; rs7525199; rs36026330; rs6665305; rs12084035; rs1748018; rs35442836; rs6695312; rs28814405; rs36142431; rs11587622; rs12085761; rs36070985; rs7530463; rs34871124; rs35111705; rs12733748; rs12752435; rs34364752; rs34212819; rs16825114; rs11203374; rs11203375; rs11800039; rs11800688; rs11801266; rs11801319; rs11809800; rs12044826; rs1204868; rs1204869; rs1204871; rs1204872; rs1204874; rs1204875; rs1204876; rs1204878; rs1204880; rs1204881; rs1204882; rs1204883; rs1204884; rs1204890; rs1204891; rs1204892; rs12048953; rs12059782; rs12096509; rs12098152; rs12732819; rs12753129; rs12760347; rs12760504; rs2477136; rs2477137; rs2477138; rs2477141; rs2477142; rs2501778; rs2501779; rs2501781; rs2501782; rs2501785; rs2501786; rs2501787; rs2501788; rs2501789; rs2501793; rs2501794; rs2985375; rs2985376; rs2985377; rs3003449; rs3094885; rs4625336; rs6586516; rs6656582; rs6657142; rs6688265; rs6690363; rs6702029; rs6702779; rs7411021; rs7534816; rs7538597; rs877551; rs877552; rs877553; rs942459

# Metabolic_Enzyme_16_General_References:
10488123

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5869

# Metabolic_Enzyme_17_Name:
AMP deaminase 3

# Metabolic_Enzyme_17_Synonyms:
AMP deaminase isoform E; Erythrocyte AMP deaminase

# Metabolic_Enzyme_17_Gene_Name:
AMPD3

# Metabolic_Enzyme_17_Protein_Sequence:
>AMP deaminase 3
MPRQFPKLNISEVDEQVRLLAEKVFAKVLREEDSKDALSLFTVPEDCPIGQKEAKERELQ
KELAEQKSVETAKRKKSFKMIRSQSLSLQMPPQQDWKGPPAASPAMSPTTPVVTGATSLP
TPAPYAMPEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYARLAYHRFPRITSQY
LGHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEH
QEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKEL
KSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFD
GLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARM
VKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIF
RSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDK
SPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF
LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSL
STDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYY
KEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTN

# Metabolic_Enzyme_17_Number_of_Residues:
767

# Metabolic_Enzyme_17_Molecular_Weight:
88813

# Metabolic_Enzyme_17_Theoretical_pI:
6.98

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Not Available

# Metabolic_Enzyme_17_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_17_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_17_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_17_Signals:
None

# Metabolic_Enzyme_17_Transmembrane_Regions:
None

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_17_GenBank_ID_Protein:
219457

# Metabolic_Enzyme_17_SwissProt_ID:
AMPD3_HUMAN (Q01432)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
AMPD3

# Metabolic_Enzyme_17_Geneatlas_id:
AMPD3

# Metabolic_Enzyme_17_hgnc_id:
HGNC:470

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_17_Gene_Sequence:
>2304 bp
ATGCCGCGGCAGTTTCCCAAGCTGAACATCTCTGAAGTGGATGAGCAAGTCCGGCTCCTG
GCGGAGAAGGTGTTTGCTAAAGTGCTCCGAGAAGAGGACAGCAAAGATGCCCTGTCCCTG
TTCACTGTCCCAGAGGACTGCCCCATCGGGCAAAAGGAAGCCAAGGAGAGGGAGCTGCAG
AAGGAGCTGGCAGAGCAGAAGTCTGTGGAGACCGCAAAAAGAAAGAAAAGTTTCAAGATG
ATTCGGTCCCAGTCCCTGTCTCTGCAAATGCCGCCACAGCAAGATTGGAAGGGCCCCCCG
GCAGCCAGTCCGGCCATGTCTCCCACAACCCCTGTGGTCACTGGAGCCACTTCCCTGCCC
ACGCCAGCACCCTATGCCATGCCTGAGTTCCAGCGGGTCACCATCAGCGGAGATTACTGT
GCCGGGATCACTTTGGAGGACTATGAGCAGGCAGCCAAGAGTCTGGCCAAGGCCCTAATG
ATCCGGGAGAAGTATGCGCGGCTCGCCTACCACCGCTTCCCGCGGATCACATCCCAGTAC
CTGGGTCATCCGCGGGCGGATACTGCACCTCCGGAAGAGGGCCTTCCAGACTTCCACCCT
CCTCCACTGCCCCAGGAAGACCCCTACTGCCTGGATGATGCACCCCCCAACCTGGATTAC
TTGGTCCACATGCAGGGGGGCATCCTCTTTGTGTATGATAACAAGAAGATGCTGGAGCAC
CAGGAGCCGCACAGCCTACCCTACCCCGACCTGGAGACCTACACGGTGGACATGAGCCAC
ATCCTGGCTCTCATCACCGATGGCCCCACGAAAACCTATTGTCACCGGCGACTGAACTTT
CTGGAATCCAAGTTCAGCCTTCATGAGATGTTAAACGAAATGTCCGAGTTCAAAGAGTTG
AAGAGTAACCCCCACCGGGACTTCTATAACGTGAGAAAGGTGGACACACACATCCATGCG
GCCGCCTGCATGAACCAAAAGCATCTGCTGCGCTTCATCAAGCACACATACCAGACGGAG
CCTGACAGGACTGTGGCAGAGAAGCGGGGCCGGAAGATCACCCTGCGGCAGGTGTTTGAC
GGCCTGCACATGGACCCCTACGACCTCACTGTGGACTCACTGGATGTCCACGCGGGCCGG
CAGACATTCCACCGCTTTGACAAGTTCAACTCCAAATACAACCCTGTGGGGGCCAGTGAG
CTGCGTGACCTGTATTTGAAAACTGAAAACTATCTGGGAGGAGAGTACTTTGCTCGGATG
GTCAAGGAGGTTGCCCGGGAGCTGGAGGAGAGCAAGTACCAGTACTCAGAGCCACGGCTC
TCCATCTACGGCCGCAGTCCTGAGGAGTGGCCCAACCTGGCCTACTGGTTCATCCAGCAC
AAGGTCTACTCTCCCAACATGCGCTGGATCATCCAGGTGCCCCGGATTTATGACATATTT
AGGTCAAAGAAGCTGCTGCCAAACTTTGGGAAGATGCTGGAGAACATCTTCCTGCCCCTT
TTCAAGGCCACTATCAACCCCCAAGATCATCGAGAGCTTCACCTCTTCCTTAAATATGTG
ACGGGGTTTGACAGCGTGGATGATGAGTCCAAGCACAGCGACCACATGTTTTCCGACAAG
AGCCCAAACCCGGACGTCTGGACCAGTGAGCAGAACCCACCCTACAGCTACTACCTGTAC
TACATGTATGCCAACATCATGGTGCTCAACAACCTCCGCAGGGAGCGCGGCCTGAGCACG
TTCCTGTTCCGGCCGCACTGTGGGGAAGCCGGCTCCATCACCCACCTGGTGTCTGCCTTC
CTCACTGCTGACAACATTTCCCACGGGCTGCTCCTCAAGAAGAGTCCGGTATTGCAGTAT
CTCTACTACCTTGCTCAGATCCCCATTGCCATGTCTCCTCTTAGCAACAACAGTTTGTTC
CTCGAATATTCCAAGAACCCTCTGAGGGAATTCCTACACAAGGGACTGCATGTTTCTCTT
TCCACCGATGACCCCATGCAGTTCCACTACACGAAGGAAGCACTTATGGAAGAATATGCC
ATTGCAGCTCAAGTGTGGAAGCTGAGCACCTGCGACCTGTGTGAGATCGCCAGGAACAGC
GTGCTGCAGAGCGGCCTCTCGCATCAGGAAAAGCAAAAGTTTCTGGGACAAAATTATTAT
AAAGAAGGACCTGAAGGAAATGATATTCGAAAGACAAATGTGGCTCAGATCCGGATGGCA
TTCCGATATGAGACCTTATGCAATGAGCTCAGCTTCCTGTCTGATGCTATGAAATCAGAA
GAGATCACCGCCTTGACCAACTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
D12775

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_17_Locus:
11p15

# Metabolic_Enzyme_17_SNPs:
rs11042836; rs36003153; rs3741041; rs16907852; rs34319136; rs11820856; rs899013; rs899011; rs899010; rs1037998; rs936513; rs936514; rs9292; rs1545743; rs7109334; rs11822997; rs930672; rs7416; rs2071020; rs7123980; rs7124144; rs2071019; rs1466426; rs2071018; rs7113101; rs1001118; rs7122280; rs11042840; rs10840419; rs3741037; rs10437597; rs10840427; rs3891547; rs2071017; rs11826750; rs10840429; rs11042854; rs12419888; rs12795565; rs11042830; rs10770120; rs11042841; rs3802917; rs11042846; rs3741038; rs11602933; rs11042853; rs7943804; rs11042849; rs17401498; rs7105307; rs11601268; rs7128132; rs12271597; rs11042855; rs11042833; rs4910146; rs7107588; rs7125606; rs12416948; rs6484336; rs4910140; rs10840424; rs11042850; rs16907878; rs11042842; rs10840425; rs11042834; rs16907858; rs11042828; rs11042848; rs899014; rs11042856; rs7127884; rs1466427; rs7124537; rs10770122; rs7934278; rs2071016; rs7125888; rs10840431; rs4910143; rs11042832; rs11042851; rs12800954; rs12284970; rs4910141; rs11042864; rs6484302; rs7934815; rs11042839; rs16907891; rs12421214; rs16907836; rs16907914; rs16907919; rs10840428; rs3741043; rs7110563; rs3741039; rs11042831; rs4910144; rs4909930; rs10770119; rs7114333; rs17310342; rs11042852; rs12290824; rs7949917; rs10840420; rs11042859; rs11042843; rs7944154; rs4909932; rs10840430; rs11042847; rs16907868; rs7101748; rs10840422; rs922360; rs10770118; rs10840421; rs16907909; rs16907896; rs7130140; rs16907917; rs7101934; rs11042835; rs12418145; rs11042844; rs11042863; rs10840423; rs7932321; rs4909931; rs7950039; rs4909928; rs7929999; rs4909929; rs7111970; rs12161765; rs6484290; rs7112321; rs6484291; rs4910139; rs3741040; rs12418097; rs1803101; rs416372; rs11278140; rs10592594; rs34205084; rs10666578; rs376859; rs35285382; rs35234722; rs34276239; rs2403330; rs433847; rs35548473; rs922359; rs35027484; rs5029459; rs34686247; rs11042817; rs2169594; rs36117985; rs28403593; rs12360830; rs35815414; rs28403594; rs35417007; rs34947038; rs11042816; rs34448488; rs34793322; rs11455471; rs7120456; rs12804742; rs35753139; rs12789944; rs12295824; rs35307925; rs35469290; rs11042827; rs11042815; rs12285554; rs10770121; rs11042837; rs10437667; rs389793; rs4909933; rs12291731; rs411593; rs12291443; rs7937616; rs11042857; rs12295125; rs5789638; rs11042813; rs34796012; rs34400211; rs10466517; rs11327316; rs35172583; rs12284303; rs10466406; rs12287821; rs36106536; rs7107965; rs11042812; rs35535464; rs36075284; rs12271609; rs446512; rs11042826; rs10466515; rs12221503; rs12293113; rs10840426; rs11042845; rs10743142; rs11042862; rs403952; rs34388590; rs34972496; rs34843534; rs12790244; rs7119606; rs11522665; rs10466514; rs12292471; rs35410520; rs12575256; rs12786914; rs12224969; rs12287504; rs35022461; rs35501680; rs34957142; rs4910142; rs12184411; rs11042860; rs16907904; rs35803105; rs34769794; rs34045306; rs35148074; rs11346179; rs11042838; rs34159907; rs4910147; rs11279688; rs34735568; rs35724616; rs10466404; rs35916834; rs7937988; rs35909829; rs12803441; rs4909934; rs4369398; rs7951269; rs11042861; rs34779745; rs34942282; rs11530493; rs11820349; rs9736934; rs11042829; rs35114038; rs10466516; rs12802491; rs12284175; rs10709823; rs11042818; rs36119682; rs35629432; rs11042858; rs12291294; rs34456454; rs36120251; rs11042814; rs11042811; rs11042825; rs36032769; rs7107565; rs7937289; rs7107698; rs7124271; rs10643285; rs36206458; rs8181594; rs7938316; rs11042810; rs10590775; rs1043778; rs10500725; rs1074375; rs10770123; rs10840415; rs10840416; rs10840417; rs10840418; rs11042805; rs11042806; rs11042865; rs11042866; rs11042867; rs11042868; rs11602469; rs11607008; rs12164827; rs12225339; rs12280618; rs12290357; rs12363993; rs12448; rs12789639; rs16907826; rs1870951; rs3177103; rs3741036; rs374925; rs382044; rs383090; rs394242; rs411783; rs4146830; rs428325; rs446762; rs4910149; rs4910150; rs570362; rs6484281; rs677322; rs7119498; rs7939845; rs7948437; rs899012; rs9971562

# Metabolic_Enzyme_17_General_References:
1420359; 1400401; 8611627; 8004104

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5947

# Metabolic_Enzyme_18_Name:
Pyridoxine-5'-phosphate oxidase

# Metabolic_Enzyme_18_Synonyms:
Pyridoxamine-phosphate oxidase

# Metabolic_Enzyme_18_Gene_Name:
PNPO

# Metabolic_Enzyme_18_Protein_Sequence:
>Pyridoxine5'phosphate oxidase
MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAFEETHLTSLDPVK
QFAAWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKE
LDSNPFASLVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIGAVVSHQSSVIPD
REYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGD
SPLGPMTHRGEEDWLYERLAP

# Metabolic_Enzyme_18_Number_of_Residues:
261

# Metabolic_Enzyme_18_Molecular_Weight:
29988

# Metabolic_Enzyme_18_Theoretical_pI:
7.09

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  pyridoxamine-phosphate oxidase activity
Function:  binding
Function:  nucleotide binding
Function:  FMN binding
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  vitamin metabolism
Process:  water-soluble vitamin metabolism
Process:  vitamin B6 metabolism
Process:  pyridoxine metabolism
Process:  pyridoxine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
Oxidizes PNP and PMP into pyridoxal 5'-phosphate (PLP)

# Metabolic_Enzyme_18_Pathway:
map00750  Vitamin B6 metabolism

# Metabolic_Enzyme_18_Reaction:
pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + ammonia + H2O2

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF01243:Pyridox_oxidase

# Metabolic_Enzyme_18_Signals:
None

# Metabolic_Enzyme_18_Transmembrane_Regions:
None

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 1.4.3.5

# Metabolic_Enzyme_18_GenBank_ID_Protein:
21728336

# Metabolic_Enzyme_18_SwissProt_ID:
PNPO_HUMAN (Q9NVS9)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
PNPO

# Metabolic_Enzyme_18_Geneatlas_id:
PNPO

# Metabolic_Enzyme_18_hgnc_id:
HGNC:30260

# Metabolic_Enzyme_18_PDB_ID:
1NRG

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Not Available

# Metabolic_Enzyme_18_Gene_Sequence:
>786 bp
ATGACGTGCTGGCTGCGGGGCGTCACGGCGACGTTCGGGCGACCTGCCGAGTGGCCAGGC
TACCTCAGTCACCTGTGTGGTCGCAGTGCTGCCATGGACCTGGGACCCATGCGCAAGAGT
TACCGCGGGGACCGAGAGGCATTTGAGGAGACTCATCTGACCTCCCTTGACCCAGTGAAA
CAGTTTGCTGCCTGGTTTGAGGAGGCTGTTCAGTGTCCTGACATAGGGGAAGCCAATGCC
ATGTGTCTGGCTACCTGCACCAGAGATGGAAAACCCTCTGCTCGCATGTTGCTGCTGAAG
GGCTTCGGGAAAGATGGCTTCCGCTTCTTCACTAACTTCGAGAGTCGAAAAGGAAAAGAG
CTGGACTCTAATCCCTTTGCTTCCCTTGTCTTCTACTGGGAGCCACTTAACCGTCAGGTG
CGTGTGGAAGGCCCTGTGAAGAAACTGCCTGAGGAGGAGGCTGAGTGCTACTTCCACTCC
CGCCCCAAGAGCAGCCAGATTGGGGCTGTGGTCAGCCACCAGAGTTCTGTGATCCCTGAT
CGGGAGTATCTGAGAAAGAAAAATGAGGAACTGGAACAGCTCTACCAGGATCAAGAGGTG
CCCAAGCCAAAATCCTGGGGTGGCTATGTCCTGTACCCTCAGGTGATGGAGTTCTGGCAA
GGTCAAACCAACCGCCTGCATGACCGGATAGTCTTTCGGCGGGGCCTACCCACAGGAGAT
TCCCCTTTGGGGCCCATGACCCACCGCGGGGAGGAAGACTGGCTCTATGAGAGACTTGCA
CCTTAA

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF468030

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:17

# Metabolic_Enzyme_18_Locus:
17q21.32

# Metabolic_Enzyme_18_SNPs:
rs17679445; rs11079804; rs4378657; rs7220104; rs7219707; rs2325749; rs16949676; rs2002136; rs16949651; rs11079803; rs2325750; rs9894340; rs2325751; rs1986694; rs7208554; rs3764398; rs35974730; rs1962201; rs35312568; rs34482109; rs34388466; rs10665680; rs35685159; rs7214659; rs35742801; rs3047638; rs11657774; rs28547560; rs4539646; rs7210233; rs11079802; rs11545723; rs11650043; rs11651753; rs11652185; rs11652827; rs12449469; rs12453525; rs12939788; rs12941340; rs12951323; rs16949720; rs16949737; rs16949761; rs17617250; rs1986693; rs2597169; rs2597170; rs2875735; rs3096; rs34428844; rs3764396; rs3764399; rs3826396; rs4538050; rs4793729; rs4793733; rs4793734; rs4794318; rs6503934; rs8065349; rs9896981; rs9908317; rs9909897

# Metabolic_Enzyme_18_General_References:
12824491

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5948

# Metabolic_Enzyme_19_Name:
Glutaminase liver isoform, mitochondrial precursor

# Metabolic_Enzyme_19_Synonyms:
GLS; L-glutamine amidohydrolase; L-glutaminase

# Metabolic_Enzyme_19_Gene_Name:
GLS2

# Metabolic_Enzyme_19_Protein_Sequence:
>Glutaminase liver isoform, mitochondrial precursor
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV

# Metabolic_Enzyme_19_Number_of_Residues:
602

# Metabolic_Enzyme_19_Molecular_Weight:
66324

# Metabolic_Enzyme_19_Theoretical_pI:
7.32

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_19_Specific_Function:
Plays an important role in the regulation of glutamine catabolism

# Metabolic_Enzyme_19_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_19_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_19_GenBank_ID_Protein:
6650606

# Metabolic_Enzyme_19_SwissProt_ID:
GLSL_HUMAN (Q9UI32)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
GLS2

# Metabolic_Enzyme_19_Geneatlas_id:
GLS2

# Metabolic_Enzyme_19_hgnc_id:
HGNC:29570

# Metabolic_Enzyme_19_PDB_ID:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_19_Gene_Sequence:
>1809 bp
ATGCGCTCCATGAAGGCTCTGCAGAAGGCCCTGAGCCGGGCTGGCAGTCACTGCGGGCGA
GGAGGCTGGGGTCACCCGAGCCGGAGCCCCCTCCTTGGCGGGGGCGTCCGGCACCACCTC
AGTGAGGCCGCGGCGCAGGGCAGAGAGACGCCACACAGCCACCAGCCGCAGCACCAGGAT
CATGATTCATCAGAAAGTGGCATGCTGTCCCGCCTGGGTGATTTGCTCTTTTACACTATT
GCTGAAGGACAGGAACGAACCCCTATCCACAAGTTCACCACTGCACTAAAGGCCACTGGA
CTGCAGACATCAGATCCTCGGCTCCGAGACTGCATGAGCGAGATGCACCGCGTGGTCCAA
GAGTCCAGTAGTGGTGGCCTCTTGGACCGAGATCTCTTCCGAAAGTGTGTGAGCAGCAGC
ATTGTGCTCCTGACCCAGGCATTCCGAAAGAAGTTTGTCATTCCTGATTTTGAGGAGTTC
ACGGGCCATGTGGATCGCATCTTTGAGGATGTCAAAGAGCTCACTGGAGGCAAAGTGGCA
GCCTACATCCCTCAGCTGGCCAAGTCAAACCCAGACCTGTGGGGTGTCTCCCTGTGCACT
GTGGATGGTCAACGGCACTCTGTGGGCCACACAAAGATCCCCTTCTGCCTGCAGTCCTGT
GTGAAGCCCCTCACCTATGCCATCTCCATAAGCACCCTAGGCACTGACTACGTGCACAAG
TTTGTGGGCAAAGAGCCAAGTGGCCTGCGCTACAACAAGCTCTCCCTCGATGAGGAAGGA
ATCCCCCATAACCCCATGGTCAATGCTGGTGCCATTGTTGTCAGCTCCCTGATCAAGATG
GACTGTAACAAAGCAGAGAAGTTTGATTTTGTGTTGCAGTATCTCAACAAAATGGCTGGG
AATGAATACATGGGTTTCAGCAATGCCACATTCCAGTCAGAGAAGGAAACAGGGGATCGG
AATTATGCCATCGGCTATTATCACGAGGAAAAGAAGTGCTTTCCTAAGGGGGTGGACATG
ATGGCTGCCCTTGATCTCTACTTCCAGCTGTGTTCTGTGGAGGTCACTTGTGAATCAGGC
AGTGTCATGGCAGCCACCCTCGCCAACGGTGGGATTTGCCCCATCACAGGCGAGAGTGTG
CTGAGTGCTGAAGCAGTGCGCAACACCCTCAGCCTCATGCATTCCTGCGGCATGTATGAC
TTCTCTGGCCAGTTTGCCTTCCACGTGGGCCTGCCAGCCAAGTCAGCTGTATCAGGAGCC
ATCCTCCTGGTGGTACCCAATGTCATGGGAATGATGTGCCTGTCACCCCCATTGGACAAG
CTGGGGAACAGCCATAGGGGGACCAGCTTCTGCCAGAAGTTGGTGTCTCTCTTCAATTTC
CACAACTATGACAACCTGAGGCACTGTGCTCGGAAGTTAGACCCACGGCGTGAAGGGGCA
GAAATTCGGAACAAGACTGTGGTCAACCTGTTATTTGCTGCCTATAGTGGCGATGTCTCA
GCTCTTCGAAGGTTTGCCTTGTCAGCCATGGATATGGAACAGAAAGACTATGACTCGCGC
ACAGCTCTGCATGTTGCTGCAGCTGAAGGACACATCGAAGTTGTTAAATTCCTGATCGAG
GCTTGCAAAGTGAATCCTTTTGCCAAGGACAGGTGGGGCAACATTCCCCTGGATGATGCT
GTGCAGTTCAACCATCTGGAGGTGGTCAAACTGCTTCAAGATTACCAGGACTCCTACACA
CTCTCTGAAACTCAGGCTGAGGCAGCAGCTGAGGCCCTGTCCAAAGAGAACTTAGAAAGC
ATGGTATGA

# Metabolic_Enzyme_19_GenBank_ID_Gene:
AF110330

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_19_Locus:
12q13

# Metabolic_Enzyme_19_SNPs:
rs2657879; rs1043011; rs2638315; rs937115; rs7314242; rs937114; rs6581096; rs2638314; rs11171863; rs12299914; rs2638335; rs4759244; rs7137402; rs12304519; rs7306152; rs2638336; rs7312783; rs2657878; rs11171862; rs3809122; rs2638334; rs11834429; rs3211277; rs34265700; rs2279536; rs12229485; rs5798384; rs11439704; rs35400268; rs10876892; rs35894333; rs11171861; rs11441969; rs7314504; rs35171220; rs34950500; rs12819483; rs35762642; rs2657877; rs34325581; rs11414489; rs35090234; rs34646954; rs12811540; rs11171864; rs34647708; rs12811321; rs12809968; rs35530001; rs10124; rs10876891; rs12313841; rs2638285; rs2638317; rs2638318; rs2638319; rs2657880; rs2657881; rs2657914; rs7298079; rs7302925; rs765817

# Metabolic_Enzyme_19_General_References:
10620514; 11163757

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
5817

# Metabolic_Enzyme_20_Name:
Biotinidase precursor

# Metabolic_Enzyme_20_Synonyms:
Not Available

# Metabolic_Enzyme_20_Gene_Name:
BTD

# Metabolic_Enzyme_20_Protein_Sequence:
>Biotinidase precursor
MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQ
EALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRW
NPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVF
SNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRD
YKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESF
WYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHC
DEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYAL
GVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFL
TSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD

# Metabolic_Enzyme_20_Number_of_Residues:
523

# Metabolic_Enzyme_20_Molecular_Weight:
58914

# Metabolic_Enzyme_20_Theoretical_pI:
5.72

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation

# Metabolic_Enzyme_20_Pathway:
map00780  Biotin metabolism

# Metabolic_Enzyme_20_Reaction:
biotin amide + H2O = biotin + NH3

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_20_Signals:
1-21

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.5.1.12

# Metabolic_Enzyme_20_GenBank_ID_Protein:
468824

# Metabolic_Enzyme_20_SwissProt_ID:
BTD_HUMAN (P43251)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
BTD

# Metabolic_Enzyme_20_Geneatlas_id:
BTD

# Metabolic_Enzyme_20_hgnc_id:
HGNC:1122

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_20_Gene_Sequence:
>1632 bp
ATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGATTTGTGGTCTGCATT
ATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTG
GGAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCT
GCCGTGTATGAGCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAA
GAGGCCTTGGAGCTCATGAACCAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCA
GCCCAAAAGGATGTACAGATTATAGTGTTTCCAGAAGATGGCATTCATGGATTCAACTTT
ACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGGTCAGGTGG
AACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGCTCCAGCGCCTGAGTTGT
ATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCTTGTCAT
AGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTC
AGCAATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCA
TTCGATGTTCCTCTTAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTT
GGCATCTTCACATGCTTTGATATATTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGAC
TACAAGGTGAAGCATGTTGTGTACCCAACTGCCTGGATGAACCAGCTCCCACTCTTGGCA
GCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAACGTTCTGGCAGCTAAT
GTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAGTCCTTT
TGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAAT
CCAGTGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAG
TTTTTAAAAATTTTGTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGT
GATGAGGCCACCAAGTGGAACGTGAATGCTCCTCCCACATTTCACTCTGAGATGATGTAT
GACAATTTCACCCTGGTCCCTGTCTGGGGAAAGGAAGGCTATCTCCACGTCTGTTCCAAT
GGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAAAGAGCTGTATGCCCTG
GGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGTGCCCTG
GTCAGGTGTGGGGGTCTTGGCTTCGACACCTGCGGACAGGAAATCACAGAGGCCACGGGG
ATATTTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTG
ACCTCAGGGATGACCCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTC
CTGAGGAAAAGTAGGCTGTCCTCTGGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTAT
GAGAGGGACTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
U03274

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_20_Locus:
3p25

# Metabolic_Enzyme_20_SNPs:
rs35034250; rs13078881; rs3817641; rs924814; rs2471809; rs2455826; rs4094397; rs2455820; rs9853116; rs2455810; rs1021849; rs2455916; rs9880034; rs4478067; rs2280770; rs13320591; rs760066; rs2471807; rs11128749; rs7651039; rs6773682; rs2455827; rs2470526; rs12489825; rs2455823; rs2470529; rs2455915; rs10510441; rs13319547; rs741747; rs741748; rs9858977; rs9310480; rs9866477; rs1296433; rs2734308; rs9858784; rs7640807; rs34356435; rs9310481; rs9849809; rs10212184; rs12330387; rs7621332; rs4626087; rs9827673; rs4309707; rs9825546; rs2455828; rs9310479; rs9830528; rs17041367; rs2470551; rs12639040; rs6807875; rs9836533; rs2174267; rs28934601; rs35976361; rs13073139; rs34885143; rs35145938; rs28475858; rs28612795; rs2055564; rs9838247; rs13066152; rs12494340; rs11714810; rs34101231; rs34976221; rs11916854; rs2471806; rs4298027; rs2470528; rs2455918; rs6803821; rs12493340; rs35141065; rs35452512; rs2470541; rs2654647; rs12631444; rs2455825; rs13068169; rs9873582; rs13075998; rs35719864; rs4685254; rs2734309; rs35863533; rs35004427; rs10621505; rs28576968; rs36065590; rs11915606; rs12330789; rs4407396; rs11717801; rs13088542; rs9755; rs35369543; rs7620644; rs9825684; rs4582034; rs35742912; rs28450862; rs28758269; rs34826323; rs7429324; rs2470527; rs13099874; rs35741795; rs34655059; rs9867921; rs36018115; rs2455822; rs2455824; rs28374257; rs6800368; rs1504098; rs1875798; rs2455917; rs9882597; rs11369757; rs11405819; rs6773959; rs35402548; rs9838246; rs34597886; rs36078683; rs35244780; rs2455821; rs35735277; rs9847991; rs9840496; rs34143777; rs34795748; rs2280771; rs12488812; rs34408221; rs28553993; rs9868928; rs9870498; rs35638740; rs13061544; rs34718841; rs35175965; rs2470525; rs4684257; rs36053401; rs11918810; rs12490588; rs13076664; rs13076834; rs13076843; rs13099347; rs1504099; rs2004783; rs2014933; rs2019160; rs2089054; rs2134784; rs2279841; rs2455852; rs2455853; rs2455854; rs2470530; rs2470531; rs2470532; rs2734307; rs3732720; rs3796302; rs3796305; rs6773994; rs6784844; rs6804782; rs7626148; rs869569; rs905555; rs9647358; rs9830541; rs9834785; rs9879788

# Metabolic_Enzyme_20_General_References:
7509806; 9530634; 9099842; 9654207

# Metabolic_Enzyme_20_References:
Not Available

# Metabolic_Enzyme_21_ID:
5627

# Metabolic_Enzyme_21_Name:
Amiloride-sensitive amine oxidase [copper-containing] precursor

# Metabolic_Enzyme_21_Synonyms:
Diamine oxidase; DAO; Amiloride-binding protein; ABP; Histaminase; Kidney amine oxidase; KAO

# Metabolic_Enzyme_21_Gene_Name:
ABP1

# Metabolic_Enzyme_21_Protein_Sequence:
>Amiloridesensitive amine oxidase coppercontaining precursor
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS
TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP
GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR
CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG
KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP
RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG
GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE
MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH
ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT
NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM
ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI
ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD
NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV

# Metabolic_Enzyme_21_Number_of_Residues:
751

# Metabolic_Enzyme_21_Molecular_Weight:
85342

# Metabolic_Enzyme_21_Theoretical_pI:
7.01

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_21_Specific_Function:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function

# Metabolic_Enzyme_21_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_21_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_21_GenBank_ID_Protein:
177960

# Metabolic_Enzyme_21_SwissProt_ID:
ABP1_HUMAN (P19801)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ABP1

# Metabolic_Enzyme_21_Geneatlas_id:
ABP1

# Metabolic_Enzyme_21_hgnc_id:
HGNC:80

# Metabolic_Enzyme_21_PDB_ID:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_21_Gene_Sequence:
>2142 bp
ATGCCGGCCCTGGGCTGGGCCGTGGCTGCCATCCTGATGCTGCAGACGGCCATGGCGGAG
CCCTCCCCGGGGACTCTGCCCAGGAAGGCAGGGGTGTTTTCAGACCTAAGCAACCAAGAG
CTGAAGGCAGTGCACAGCTTCCTCTGGTCCAAGAAGGAGCTGAGGCTGCAGCCCTCCAGT
ACCACCACCATGGCCAAGAACACCGTGTTTCTCATCGAGATGCTGCTGCCCAAGAAGTAC
CATGTGCTGAGGTTTCTGGATAAAGGTGAAAGGCATCCTGTGCGGGAAGCCCGTGCCGTC
ATCTTCTTTGGTGACCAGGAGCATCCCAATGTCACCGAGTTTGCTGTGGGGCCCCTGCCA
GGGCCCTGCTACATGCGAGCACTGTCCCCCAGGCCTGGGTACCAGTCCTCCTGGGCATCG
AGGCCCATCTCCACAGCAGAGTATGCCCTCCTCTACCACACCCTGCAGGAAGCCACCAAG
CCCCTGCATCAGTTCTTCCTCAATACCACAGGCTTCTCATTCCAAGACTGCCATGACAGA
TGCCTGGCCTTCACCGATGTGGCCCCCCGGGGTGTGGCTTCTGGCCAGCGCCGCAGTTGG
CTTATCATACAGCGCTATGTAGAAGGCTACTTTCTGCACCCCACTGGGCTGGAGCTCCTC
GTGGATCATGGGAGCACAGATGCTGGGCACTGGGCCGTGGAGCAGGTGTGGTACAACGGG
AAGTTCTATGGGAGCCCAGAGGAACTGGCACGGAAGTATGCAGATGGAGAGGTGGACGTG
GTGGTCCTGGAGGACCGCTGCCTGGGGGCAAGGGGCATGACAGCACAGAGGAGCCGGCCC
TCTTCTCCTCCACAAGCCCCGCGGGACTTTCCCCAGCCCCATCCATGTGAGCGGCCCCCG
CTTGGTCCAGCCCCACGGCCCTCGCTTCAGGCTGGAGGGCAACGCTGTGCTCTACGGCGG
CTGGAGCTTTGCCTTCCGGTGCGCTCCTCCTCCGGGCTGCAGGTCCTGAACGTGCACTTC
GGCGGAGAGCGCATTGCCTATGAGGTCAGCGTGCAAGAGGCAGTGGCGCTGTATGGAGGA
CACACACCTGCAGGCATGCAGACCAAGTACCTCGATGTCGGCTGGGGCCTGGGCAGCGTC
ACTCATGAGTTAGCCCCCGGCATCGACTGCCCGGAGACCGCCACCTTCCTGGACACTTTC
CACTACTATGATGCCGATGACCCGGTCCATTATCCCCGAGCCCTCTGCCTCTTTGAAATG
CCCACAGGGGTGCCCCTTCGGCGGCACTTTAATTCCAACTTTAAAGGTGGCTTCAACTTC
TATGCAGGGCTGAAGGGCCAGGTGCTGGTGCTGCGGACAACTTCAACTGTCTACAATTAT
GATTACATTTGGGACTTTATCTTCTACCCCAACGGGGTGATGGAGGCCAAGATGCATGCC
ACTGGCTACGTCCACGCCACCTTCTACACCCCCGAGGGCTGCGCACGGCACTCGCCTGCA
CACCCACCTGATTGGCAACATACACACTCACTTGTGCACTACCGCGTAGACCTGGATGTG
GCAGGCACCAAGAACAGCTTCCAGACACTGCAGATGAAGCTAGAAAACATCACCAACCCC
TGGAGCCCGAGACACCGCGTGGTCCAGCCAACTCTGGAGCAGACGCAGTACTCCTGGGAG
CGCCAGGCGGCCTTCCGCTTCAAAAGGAGGCTGCCCAAGTACCTGCTCTTTACCAGCCCC
CAGGAGAACCCCTGGGGCCACAAGCGCAGCTACCGCCTGCAGATCCACTCCATGGCCGAC
CAGGTGCTGCCCCCAGGCTGGCAGGAGGAGCAGGCCATCACCTGGGCAAGGTACCCCCTG
GCAGTGACCAAGTACCGGGAGTCAGAGCTGTGCAGCAGCAGCATCTACCACCAGAACGAC
CCCTGGGACCCGCCCGTGGTCTTTGAGCAGTTTCTTCACAACAACGAGAACATTGAAAAT
GAGGACCTGGTGGCCTGGGTGACGGTGGGCTTCCTGCACATCCCCCACTCAGAGGACATT
CCCAACACAGCCACACCTGGGAACTCCGTGGGCTTCCTGCTCCGGCCATTCAACTTCTTC
CCAGAGGACCCCTCCCCTCCCTGGCATCCAGAGACACTGTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
M55602

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_21_Locus:
7q34-q36

# Metabolic_Enzyme_21_SNPs:
rs10156191; rs1049742; rs35070995; rs1049793; rs1049748; rs10893; rs2071514; rs4725373; rs10441169; rs2268998; rs2071513; rs10156189; rs2268999; rs7786439; rs12539; rs12540862; rs11771771; rs2071515; rs11981415; rs11981217; rs3735076; rs10952294; rs4725968; rs2301257; rs2373876; rs10273373; rs2052130; rs2052129; rs2071517; rs17173645; rs2301256; rs4725375; rs4725970; rs35929142; rs6943147; rs41465145; rs6943420; rs10441176; rs7787074; rs7786420; rs7786526; rs35730790; rs10281706; rs35773682; rs8180720; rs13235597; rs13235592; rs13235484; rs34532106; rs4725969; rs4725374; rs4431514; rs35724462; rs10273148; rs34459590; rs34090933; rs35411492; rs34502771; rs1005389; rs1005390; rs10230025; rs10236489; rs10240738; rs10249948; rs10250599; rs10250704; rs10254616; rs10254802; rs10268640; rs11760854; rs11771001; rs11971392; rs11976328; rs11978239; rs12374688; rs12374823; rs12375106; rs1476867; rs2215563; rs2215564; rs4725376; rs4725377; rs4725971; rs6977081; rs6977381; rs7793572; rs7798657; rs887587; rs887588

# Metabolic_Enzyme_21_General_References:
2217167; 8182053; 8595053; 8144586

# Metabolic_Enzyme_21_References:
Not Available

# Metabolic_Enzyme_22_ID:
5937

# Metabolic_Enzyme_22_Name:
Adenosine deaminase

# Metabolic_Enzyme_22_Synonyms:
Adenosine aminohydrolase

# Metabolic_Enzyme_22_Gene_Name:
ADA

# Metabolic_Enzyme_22_Protein_Sequence:
>Adenosine deaminase
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL

# Metabolic_Enzyme_22_Number_of_Residues:
363

# Metabolic_Enzyme_22_Molecular_Weight:
40765

# Metabolic_Enzyme_22_Theoretical_pI:
5.80

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  adenosine deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_22_Specific_Function:
Adenosine + H(2)O = inosine + NH(3)

# Metabolic_Enzyme_22_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_22_Reaction:
adenosine + H2O = inosine + ammonia

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 3.5.4.4

# Metabolic_Enzyme_22_GenBank_ID_Protein:
28380

# Metabolic_Enzyme_22_SwissProt_ID:
ADA_HUMAN (P00813)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
ADA

# Metabolic_Enzyme_22_Geneatlas_id:
ADA

# Metabolic_Enzyme_22_hgnc_id:
HGNC:186

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_22_Gene_Sequence:
>1092 bp
ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAAGTAGAACTGCATGTCCACCTAGACGGA
TCCATCAAGCCTGAAACCATCTTATACTATGGCAGGAGGAGAGGGATCGCCCTCCCAGCT
AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC
TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGCGGGCTGCCGGGAGGCTATCAAA
AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG
CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG
GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAAC
TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC
TACCAGGAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG
GCCGAAGTAGTAAAAGAGGCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC
CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC
ATTCGGCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC
AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG
GAGTTTAAAAGGCTGAACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG
AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAGGG
CAGAACCTCTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
X02994

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_22_Locus:
20q12-q13.11

# Metabolic_Enzyme_22_SNPs:
rs244076; rs11906526; rs427224; rs244078; rs2299686; rs2224999; rs379863; rs8119702; rs8119756; rs244075; rs2299691; rs2007515; rs2057637; rs762539; rs447833; rs2057638; rs6031682; rs6031690; rs6031686; rs2299688; rs6031689; rs371927; rs244079; rs2007720; rs1799880; rs2299692; rs395209; rs399159; rs2299690; rs11700291; rs929089; rs406383; rs2057639; rs967807; rs244073; rs2299694; rs452159; rs2157436; rs6031693; rs2299687; rs6017375; rs446125; rs2477898; rs6103795; rs6017378; rs445170; rs6031685; rs765215; rs6031695; rs1810751; rs2299697; rs433875; rs6031688; rs6094011; rs765216; rs244072; rs6031687; rs2299689; rs427483; rs427499; rs11907906; rs12480490; rs6103803; rs6031697; rs6017371; rs6031678; rs375379; rs384851; rs395896; rs450043; rs6094005; rs6031679; rs11698539; rs389308; rs11086932; rs6103804; rs6065738; rs1042360; rs11555566; rs7344760; rs6031698; rs394105; rs36216718; rs5841559; rs34853885; rs6017373; rs34665505; rs2765290; rs3831638; rs35553416; rs2515692; rs6031694; rs6103801; rs6103792; rs36222732; rs10561362; rs6103799; rs35009045; rs6094008; rs2007704; rs11474041; rs6103794; rs445725; rs11905649; rs6017376; rs457669; rs35383274; rs6103796; rs368253; rs6130653; rs6031691; rs11468750; rs8118045; rs6094004; rs455368; rs11484279; rs6031696; rs912912; rs6103800; rs6031684; rs445856; rs6094007; rs6017377; rs755144; rs6094009; rs11481765; rs382464; rs6103789; rs35712615; rs404898; rs6124654; rs929088; rs6031692; rs35863085; rs414146; rs6031681; rs413816; rs6103790; rs6031683; rs35436165; rs35935728; rs11698497; rs11373171; rs3091476; rs36013790; rs5841560; rs11907079; rs6103793; rs34344438; rs6017374; rs34081313; rs35535317; rs6130651; rs7353732; rs11484329; rs3041775; rs451499; rs3787359; rs11476459; rs7262528; rs6103797; rs34225524; rs11480982; rs34830340; rs6094010; rs6094006; rs3787360; rs6073497; rs11473840; rs13036408; rs34044957; rs244074; rs6103788; rs6017372; rs386512; rs35483396; rs11468701; rs2299695; rs244077; rs35505353; rs36102321; rs35545345; rs6103802; rs6103791; rs6103798; rs3831639; rs34833873; rs35784536; rs35587028; rs420183; rs6130652; rs10645831; rs36216716; rs435679; rs36216717; rs6031700; rs35153391; rs1061662; rs11699718; rs1886849; rs2071878; rs2148040; rs244081; rs244082; rs244086; rs244087; rs2664524; rs2664557; rs2664560; rs2664582; rs2664585; rs2868116; rs3180636; rs4810427; rs4810428; rs6017369; rs6031673; rs6031674; rs6031675; rs6031676; rs6031677; rs6031702; rs6031704; rs6065739; rs6094001; rs6094002; rs6094003; rs6094016; rs6094017; rs6103786; rs6103787; rs6103805; rs6103806; rs6130650; rs6130654; rs7266968; rs8118020; rs927784

# Metabolic_Enzyme_22_General_References:
6090454; 6546794; 3839456; 3028473; 11780052; 6688808; 8031011; 6208479; 3839802; 3182793; 2783588; 1284479; 8227344; 8299233; 8589684; 7599635; 9225964

# Metabolic_Enzyme_22_References:
Not Available

# Metabolic_Enzyme_23_ID:
5949

# Metabolic_Enzyme_23_Name:
CTP synthase 1

# Metabolic_Enzyme_23_Synonyms:
UTP--ammonia ligase 1; CTP synthetase 1

# Metabolic_Enzyme_23_Gene_Name:
CTPS

# Metabolic_Enzyme_23_Protein_Sequence:
>CTP synthase 1
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD

# Metabolic_Enzyme_23_Number_of_Residues:
591

# Metabolic_Enzyme_23_Molecular_Weight:
66691

# Metabolic_Enzyme_23_Theoretical_pI:
6.42

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  CTP synthase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  pyrimidine nucleotide metabolism
Process:  pyrimidine nucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_23_Specific_Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

# Metabolic_Enzyme_23_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_23_Reaction:
ATP + UTP + NH3 = ADP + phosphate + CTP

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF06418:CTP_synth_N;
PF00117:GATase

# Metabolic_Enzyme_23_Signals:
None

# Metabolic_Enzyme_23_Transmembrane_Regions:
None

# Metabolic_Enzyme_23_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_23_EC_Link:
EC 6.3.4.2

# Metabolic_Enzyme_23_GenBank_ID_Protein:
30293

# Metabolic_Enzyme_23_SwissProt_ID:
PYRG1_HUMAN (P17812)

# Metabolic_Enzyme_23_swissprot_Name:
Not Available

# Metabolic_Enzyme_23_Genecard_id:
CTPS

# Metabolic_Enzyme_23_Geneatlas_id:
CTPS

# Metabolic_Enzyme_23_hgnc_id:
HGNC:2519

# Metabolic_Enzyme_23_PDB_ID:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_23_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_23_Subcellular_Location:
Not Available

# Metabolic_Enzyme_23_Gene_Sequence:
>1776 bp
ATGAAGTACATTCTGGTTACTGGTGGTGTTATATCAGGAATTGGAAAAGGAATCATTGCC
AGCAGTGTGGGCACAATACTCAAGTCATGTGGTTTACATGTAACTTCAATCAAAATTGAC
CCCTACATTAACATTGATGCAGGAACATTCTCTCCTTATGAGCATGGTGAGGTTTTTGTG
CTGGATGATGGTGGGGAAGTAGACCTTGACCTGGGTAACTATGAGCGGTTCCTTGACATC
CGCCTCACCAAGGACAATAATCTGACCACTGGAAAGATATACCAGTATGTCATTAACAAG
GAACGGAAAGGAGATTACTTGGGGAAAACTGTCCAAGTTGTCCCTCATATCACAGATGCA
ATCCAGGAGTGGGTGATGAGACAGGCGTTAATACCTGTAGATGAAGATGGCCTGGAACCT
CAAGTGTGTGTTATTGAGCTTGGTGGAACCGTGGGGGACATAGAAAGCATGCCCTTTATT
GAGGCCTTCCGTCAGTTCCAATTCAAGGTCAAAAGAGAGAACTTTTGTAACATCCACGTC
AGTCTAGTTCCCCAGCCAAGTTCAACAGGGGAACAGAAGACTAAACCTACCCAGAATAGT
GTTCGGGAACTTAGAGGACTTGGGCTTTCCCCAGATCTGGTTGTATGCAGGTGCTCAAAT
CCACTTGACACATCAGTGAAGGAGAAAATATCAATGTTCTGCCATGTTGAGCCTGAACAA
GTGATCTGTGTCCACGATGTCTCATCCATCTACCGAGTCCCCTTGTTGTTAGAGGAGCAA
GGGGTTGTAGATTATTTTCTTCGAAGACTTGACCTTCCTATTGAGAGGCAGCCAAGAAAA
ATGCTGATGAAATGGAAAGAGATGGCTGACAGATATGATCGCTTGCTGGAGACCTGCTCT
ATTGCCCTTGTGGCGAAATACACCGAGTTCTCAGACTCCTATGCCTCTGTCATTAAGGCT
CTGGAGCATTCTGCACTGGCCATCAACCACAAATTGGAAATCAAGTACATAGATTCTGCG
GACTTGGAGCCCATCACCTCGCAAGAAGAGCCCGTGCGCTACCACGAAGCTTGGCAGAAG
CTCTGTAGTGCTCATGGAGTGCTGGTTCCAGGAGGATTTGGTGTTCGAGGAACAGAAGGA
AAAATCCAAGCAATTGCCTGGGCTCGGAATCAGAAAAAGCCTTTTTTGGGCGTGTGCTTA
GGGATGCAGTTGGCAGTGGTTGAATTCTCAAGAAACGTGCTGGGATGGCAAGATGCCAAT
TCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGGTCGTAGACATGCCAGAACACAAC
CCAGGGCAGATGGGCGGAACCATGAGGCTGGGCAAGAGGAGAACCCTGTTCCAGACCAAG
AACTCAGTCATGAGGAAACTCTATGGAGACGCAGACTACTTGGAAGAGAGGCACCGCCAC
CGATTTGAGGTGAATCCAGTCTGGAAAAAGTGTTTGGAAGAACAAGGCTTGAAGTTTGTT
GGCCAAGATGTTGAAGGAGAGAGAATGGAAATTGTGGAGTTAGAAGATCATCCCTTTTTT
GTTGGGGTTCAGTACCACCCTGAGTTCCTGTCCAGGCCTATCAAGCCCTCCCCACCATAC
TTTGGCCTCCTCCTGGCCTCTGTGGGGCGGCTCTCACATTACCTCCAGAAAGGCTGCAGG
CTCTCACCCAGGGACACCTATAGTGACAGGAGTGGAAGCAGCTCCCCTGACTCTGAAATC
ACCGAACTGAAGTTTCCATCAATAAATCATGACTGA

# Metabolic_Enzyme_23_GenBank_ID_Gene:
X52142

# Metabolic_Enzyme_23_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_23_Locus:
1p34.1

# Metabolic_Enzyme_23_SNPs:
rs4363414; rs16827810; rs7546898; rs11577910; rs11209315; rs7512775; rs12410005; rs12410096; rs12718433; rs11209342; rs12408576; rs4132438; rs6600363; rs4132440; rs7523029; rs6600362; rs7535802; rs11209331; rs3922676; rs4364871; rs7537689; rs4453027; rs12047657; rs12044786; rs35044078; rs4430318; rs12735455; rs12743340; rs13376450; rs12731155; rs4132439; rs12144160; rs11209347; rs12047078; rs12023079; rs2897231; rs2897230; rs12729920; rs3935871; rs35240983; rs17856308; rs11541594; rs36007898; rs34761170; rs5030799; rs33963815; rs11316628; rs12736067; rs5030801; rs35846227; rs34730648; rs5030800; rs7543690; rs11209312; rs4130828; rs12135912; rs6675122; rs12145744; rs12749196; rs34316011; rs34538426; rs12135364; rs35080169; rs34043964; rs35160190; rs12119675; rs4660497; rs5773721; rs35156226; rs35281195; rs28469640; rs11209349; rs12027691; rs4660496; rs12739052; rs4660182; rs11580414; rs35368773; rs34472412; rs41308258; rs11343566; rs28401673; rs34502739; rs12748235; rs6675165; rs12061505; rs34406683; rs4548429; rs36057096; rs41268101; rs12738189; rs12724936; rs12090358; rs1892553; rs12079825; rs12132595; rs3206609; rs34209541; rs10789262; rs11209361; rs11209363; rs1129661; rs1138293; rs11579483; rs11579485; rs11584051; rs12033893; rs12033917; rs12033920; rs12121539; rs12736566; rs17357905; rs17357954; rs34386830; rs35405087; rs36084778; rs3738368; rs3738369; rs4360513; rs4440845; rs4660498; rs6661890; rs6674450; rs6685430; rs7534059

# Metabolic_Enzyme_23_General_References:
2113467

# Metabolic_Enzyme_23_References:
Not Available

# Metabolic_Enzyme_24_ID:
5950

# Metabolic_Enzyme_24_Name:
Protein-arginine deiminase type-3

# Metabolic_Enzyme_24_Synonyms:
Protein-arginine deiminase type III; Peptidylarginine deiminase III

# Metabolic_Enzyme_24_Gene_Name:
PADI3

# Metabolic_Enzyme_24_Protein_Sequence:
>Proteinarginine deiminase type3
MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYISPNMERGR
ERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVDISLD
CDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHVHCLQDLEDM
SVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPEDVCEAYRHVLGQDKVSYEVP
RLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSNEDFSASPIFTDTVVFRVAPWIMTP
STLPPLEVYVCRVRNNTCFVDAVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAP
HKTLPVVFDSPRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLDSFGNLEVSPPVVANG
KEYPLGRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPA
PDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDEQVKTISINQVLSNKDLINY
NKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIP
KPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWW
NMVP

# Metabolic_Enzyme_24_Number_of_Residues:
664

# Metabolic_Enzyme_24_Molecular_Weight:
74744

# Metabolic_Enzyme_24_Theoretical_pI:
5.22

# Metabolic_Enzyme_24_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_24_General_Function:
Not Available

# Metabolic_Enzyme_24_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_24_Pathway:
Not Available

# Metabolic_Enzyme_24_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_24_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_24_Signals:
None

# Metabolic_Enzyme_24_Transmembrane_Regions:
None

# Metabolic_Enzyme_24_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_24_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_24_GenBank_ID_Protein:
6172379

# Metabolic_Enzyme_24_SwissProt_ID:
PADI3_HUMAN (Q9ULW8)

# Metabolic_Enzyme_24_swissprot_Name:
Not Available

# Metabolic_Enzyme_24_Genecard_id:
PADI3

# Metabolic_Enzyme_24_Geneatlas_id:
PADI3

# Metabolic_Enzyme_24_hgnc_id:
HGNC:18337

# Metabolic_Enzyme_24_PDB_ID:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_24_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_24_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_24_Gene_Sequence:
>1995 bp
ATGTCGCTGCAGAGAATCGTGCGTGTGTCCCTGGAGCATCCCACCAGCGCGGTGTGTGTG
GCTGGCGTGGAGACCCTCGTGGACATTTATGGGTCAGTGCCTGAGGGCACAGAAATGTTT
GAGGTCTATGGGACGCCTGGCGTGGACATCTACATCTCTCCCAACATGGAGAGGGGCCGG
GAGCGTGCAGACACCAGGCGGTGGCGCTTTGACGCGACTTTGGAGATCATCGTGGTCATG
AACTCCCCCAGCAATGACCTCAACGACAGCCATGTTCAGATTTCCTACCACTCCAGCCAT
GAGCCTCTGCCCCTAGCCTATGCGGTGCTCTACCTCACCTGTGTTGACATCTCTCTGGAT
TGCGACCTGAACTGTGAGGGAAGGCAGGACAGGAACTTTGTAGACAAGCGGCAGTGGGTC
TGGGGGCCCAGTGGGTATGGCGGCATCTTGCTGGTGAACTGTGACCGTGATGATCCGAGC
TGTGATGTCCAGGACAATTGTGACCAGCACGTGCACTGCCTGCAAGACCTGGAAGACATG
TCTGTCATGGTCCTGCGGACGCAGGGCCCTGCAGCCCTCTTTGATGACCACAAACTTGTC
CTCCATACCTCCAGCTATGATGCCAAACGGGCACAGGTCTTCCACATCTGCGGTCCTGAG
GATGTGTGTGAGGCCTATAGGCATGTGCTGGGCCAAGATAAGGTGTCCTATGAGGTACCC
CGCTTGCATGGGGATGAGGAGCGCTTCTTCGTGGAAGGCCTGTCCTTCCCTGATGCCGGC
TTCACAGGACTCATCTCCTTCCATGTCACTCTGCTGGACGACTCCAACGAGGATTTCTCG
GCATCCCCTATCTTCACTGACACTGTGGTGTTCCGAGTGGCACCCTGGATCATGACGCCC
AGCACTCTGCCACCCCTAGAGGTGTATGTGTGCCGTGTGAGGAACAACACGTGTTTTGTG
GATGCGGTGGCAGAGCTGGCCAGGAAGGCCGGCTGCAAGCTGACCATCTGCCCACAGGCC
GAGAACCGCAACGACCGCTGGATCCAGGATGAGATGGAGCTGGGCTACGTTCAGGCGCCG
CACAAGACCCTCCCGGTGGTCTTTGACTCCCCAAGGAATGGGGAACTGCAGGATTTCCCT
TACAAAAGAATCCTGGGTCCAGATTTTGGTTACGTGACTCGGGAACCACGCGACAGGTCT
GTGAGTGGCCTGGACTCCTTTGGGAACCTGGAGGTCAGCCCTCCAGTGGTGGCCAATGGG
AAAGAGTACCCCCTGGGGAGGATCCTCATTGGGGGCAACCTGCCTGGGTCAAGTGGCCGC
AGGGTCACCCAGGTGGTGCGGGACTTCCTCCATGCCCAGAAGGTGCAGCCCCCCGTGGAG
CTCTTTGTGGACTGGTTGGCCGTGGGCCATGTGGATGAGTTTCTGAGCTTTGTCCCTGTC
CCCGATGGGAAGGGCTTCCGGATGCTCCTGGCCAGCCCTGGGGCCTGCTTCAAGCTCTTC
CAGGAAAAGCAGAAGTGTGGCCACGGGAGGGCCCTCCTGTTCCAGGGGGTTGTTGATGAT
GAGCAGGTCAAGACCATCTCCATCAACCAGGTGCTCTCCAATAAAGACCTCATCAACTAC
AATAAGTTTGTGCAGAGCTGCATCGACTGGAACCGTGAGGTGCTGAAGCGGGAGCTGGGC
CTGGCAGAGTGTGACATCATTGACATCCCACAGCTCTTCAAGACCGAGAGGAAAAAAGCA
ACGGCCTTCTTCCCTGACTTGGTGAACATGCTGGTGCTGGGGAAGCACCTGGGCATCCCC
AAGCCCTTTGGGCCCATCATCAATGGCTGCTGCTGCCTGGAGGAGAAGGTGCGGTCCCTG
CTGGAGCCTCTGGGCCTCCACTGCACCTTCATTGATGACTTCACTCCATACCACATGCTG
CATGGGGAGGTGCACTGTGGCACCAATGTGTGCAGAAAGCCCTTCTCTTTCAAGTGGTGG
AACATGGTGCCCTGA

# Metabolic_Enzyme_24_GenBank_ID_Gene:
AB026831

# Metabolic_Enzyme_24_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_24_Locus:
1p36.13

# Metabolic_Enzyme_24_SNPs:
rs2272629; rs3750300; rs34097903; rs35624745; rs2293916; rs11585357; rs2293920; rs11584781; rs3763589; rs2977300; rs2977301; rs16824888; rs12135399; rs3750303; rs17424382; rs2977229; rs2977230; rs3003434; rs2977269; rs2977228; rs4920579; rs3003423; rs3003435; rs3003440; rs4363467; rs2977293; rs10888013; rs6673643; rs4920361; rs2977262; rs6586512; rs3003438; rs4462198; rs2272630; rs10888012; rs4920362; rs11203343; rs7522439; rs4920580; rs3003429; rs2293917; rs12025184; rs2977295; rs2977299; rs12562867; rs4339902; rs2272628; rs2272627; rs6682638; rs2977264; rs3753375; rs12566659; rs3003424; rs4920585; rs11586393; rs10492991; rs3890176; rs2977292; rs4595409; rs17424167; rs11585119; rs11802379; rs4920584; rs11584287; rs17458091; rs11585118; rs4920582; rs3766301; rs3003426; rs3003432; rs6679788; rs12044550; rs9803868; rs16824388; rs11203346; rs11803680; rs3829052; rs3766298; rs2977296; rs12070008; rs3003427; rs11587458; rs4920360; rs3900818; rs2977227; rs11588043; rs2977268; rs3003428; rs12037653; rs3003436; rs2977266; rs2977294; rs4920581; rs17458002; rs7531565; rs16824578; rs12058442; rs4262593; rs12035310; rs17378462; rs3003437; rs12135984; rs3003425; rs13374860; rs4920583; rs12037558; rs16824705; rs11203345; rs3003439; rs12125585; rs16824443; rs4920578; rs16824389; rs4262594; rs3003433; rs12077122; rs7520753; rs16824440; rs3750304; rs2977226; rs3003419; rs2977302; rs12404500; rs3003421; rs3763587; rs2293918; rs12032160; rs34341567; rs3003430; rs35340855; rs34177351; rs12744056; rs12743888; rs35974923; rs12079310; rs3835470; rs13374866; rs3215408; rs35100768; rs34837071; rs12077035; rs12032104; rs35532821; rs12729982; rs34316986; rs34397530; rs10617336; rs36049065; rs12035084; rs3003422; rs2977297; rs35152903; rs34668130; rs12077117; rs34173303; rs12730111; rs2977267; rs3003431; rs6669280; rs13374868; rs2977298; rs36000793; rs28504120; rs12072671; rs35179407; rs12730112; rs35198407; rs12133221; rs5772753; rs2293919; rs35886575; rs4451590; rs34916627; rs28493448; rs11274291; rs12065629; rs12135460; rs11426940; rs11581115; rs34487635; rs12034584; rs35385289; rs7545176; rs34826223; rs12127898; rs35397237; rs3003420; rs34745182; rs10492990; rs11577718; rs11587669; rs11588418; rs11808782; rs12043098; rs12073445; rs12119803; rs12129306; rs12568771; rs12725491; rs16824215; rs2293921; rs2501776; rs2977222; rs2977223; rs2977224; rs2977225; rs2977303; rs2977304; rs2977305; rs2977311; rs2977312; rs2977313; rs3003414; rs3003445; rs3123529; rs3750299; rs735280; rs735281; rs745339; rs745340

# Metabolic_Enzyme_24_General_References:
11069618

# Metabolic_Enzyme_24_References:
Not Available

# Metabolic_Enzyme_25_ID:
5951

# Metabolic_Enzyme_25_Name:
GMP reductase 2

# Metabolic_Enzyme_25_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2

# Metabolic_Enzyme_25_Gene_Name:
GMPR2

# Metabolic_Enzyme_25_Protein_Sequence:
>GMP reductase 2
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGT
FEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAI
PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI
GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVM
LGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGD
VEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC

# Metabolic_Enzyme_25_Number_of_Residues:
348

# Metabolic_Enzyme_25_Molecular_Weight:
37875

# Metabolic_Enzyme_25_Theoretical_pI:
7.25

# Metabolic_Enzyme_25_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_25_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_25_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation

# Metabolic_Enzyme_25_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_25_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_25_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_25_Signals:
None

# Metabolic_Enzyme_25_Transmembrane_Regions:
None

# Metabolic_Enzyme_25_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_25_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_25_GenBank_ID_Protein:
23451216

# Metabolic_Enzyme_25_SwissProt_ID:
GMPR2_HUMAN (Q9P2T1)

# Metabolic_Enzyme_25_swissprot_Name:
Not Available

# Metabolic_Enzyme_25_Genecard_id:
GMPR2

# Metabolic_Enzyme_25_Geneatlas_id:
GMPR2

# Metabolic_Enzyme_25_hgnc_id:
HGNC:4377

# Metabolic_Enzyme_25_PDB_ID:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_25_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_25_Subcellular_Location:
Not Available

# Metabolic_Enzyme_25_Gene_Sequence:
>1047 bp
ATGCCTCATATTGACAACGATGTGAAACTGGACTTCAAGGATGTCCTTTTGAGGCCCAAA
CGCAGTACCCTTAAGTCTCGAAGTGAGGTGGATCTCACAAGATCCTTTTCATTTCGGAAC
TCAAAGCAGACATACTCTGGGGTTCCCATCATTGCTGCCAATATGGATACTGTGGGCACC
TTTGAGATGGCCAAGGTTCTCTGTAAGTTCTCTCTCTTCACTGCTGTCCATAAGCACTAT
AGCCTCGTTCAGTGGCAAGAGTTTGCTGGCCAGAATCCTGACTGTCTTGAGCATCTGGCT
GCCAGCTCAGGCACAGGCTCTTCTGACTTTGAGCAGCTGGAACAGATCCTGGAAGCTATT
CCCCAGGTGAAGTATATATGCCTGGATGTGGCAAATGGCTACTCTGAACACTTTGTTGAA
TTTGTAAAAGATGTACGGAAGCGCTTCCCCCAGCACACCATCATGGCAGGGAATGTGGTA
ACAGGAGAGATGGTAGAAGAGCTCATCCTTTCTGGGGCTGACATCATCAAAGTGGGAATT
GGGCCAGGCTCTGTGTGTACTACTCGGAAGAAAACTGGAGTGGGGTATCCACAGCTCAGC
GCAGTGATGGAGTGTGCAGATGCTGCTCATGGCCTCAAAGGCCACATCATTTCAGATGGA
GGTTGCAGCTGTCCTGGGGATGTGGCCAAGGCTTTTGGGGCAGGAGCTGACTTCGTGATG
CTGGGTGGCATGCTGGCTGGGCACAGTGAGTCAGGTGGTGAGCTCATCGAGAGGGATGGC
AAGAAGTACAAGCTCTTCTATGGAATGAGTTCTGAAATGGCCATGAAGAAGTATGCTGGG
GGCGTGGCTGAGTACAGAGCCTCAGAGGGAAAGACAGTGGAAGTTCCTTTTAAAGGAGAT
GTGGAACATACCATCCGAGACATCCTAGGAGGGATCCGCTCTACGTGTACCTATGTGGGA
GCAGCTAAGCTCAAAGAGTTGAGCAGGAGAACTACCTTCATCCGAGTCACCCAGCAGGTG
AATCCAATCTTCAGTGAGGCGTGCTAG

# Metabolic_Enzyme_25_GenBank_ID_Gene:
AF419346

# Metabolic_Enzyme_25_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_25_Locus:
14q12

# Metabolic_Enzyme_25_SNPs:
rs34354104; rs2273304; rs12891162; rs17102265; rs1950496; rs2273305; rs11540864; rs1142733; rs17102232; rs4624073; rs34469605; rs1950495; rs10134804; rs10138628; rs10141326; rs10148135; rs11158615; rs11625433; rs11844422; rs12883582; rs12897704; rs17102177; rs17102311; rs17102313; rs17794752; rs2144487; rs2295316; rs2332229; rs34113897; rs3814815; rs4982877; rs7145550; rs7152342; rs7157595; rs7158744; rs766601; rs766602; rs8193035

# Metabolic_Enzyme_25_General_References:
12009299

# Metabolic_Enzyme_25_References:
Not Available

# Metabolic_Enzyme_26_ID:
5594

# Metabolic_Enzyme_26_Name:
Porphobilinogen deaminase

# Metabolic_Enzyme_26_Synonyms:
Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase; PBG-D

# Metabolic_Enzyme_26_Gene_Name:
HMBS

# Metabolic_Enzyme_26_Protein_Sequence:
>Porphobilinogen deaminase
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPH
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQ
QEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH
VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDA
H

# Metabolic_Enzyme_26_Number_of_Residues:
361

# Metabolic_Enzyme_26_Molecular_Weight:
39331

# Metabolic_Enzyme_26_Theoretical_pI:
7.19

# Metabolic_Enzyme_26_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring alkyl or aryl (other than methyl) groups
Function:  hydroxymethylbilane synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  porphyrin biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_26_General_Function:
Coenzyme transport and metabolism 

# Metabolic_Enzyme_26_Specific_Function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

# Metabolic_Enzyme_26_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_26_Reaction:
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3

# Metabolic_Enzyme_26_Pfam_Domain_Function:
PF01379:Porphobil_deam;
PF03900:Porphobil_deamC

# Metabolic_Enzyme_26_Signals:
None

# Metabolic_Enzyme_26_Transmembrane_Regions:
None

# Metabolic_Enzyme_26_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_26_EC_Link:
EC 2.5.1.61

# Metabolic_Enzyme_26_GenBank_ID_Protein:
35307

# Metabolic_Enzyme_26_SwissProt_ID:
HEM3_HUMAN (P08397)

# Metabolic_Enzyme_26_swissprot_Name:
Not Available

# Metabolic_Enzyme_26_Genecard_id:
HMBS

# Metabolic_Enzyme_26_Geneatlas_id:
HMBS

# Metabolic_Enzyme_26_hgnc_id:
HGNC:4982

# Metabolic_Enzyme_26_PDB_ID:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_26_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_26_Subcellular_Location:
Cytoplasm (Probable)

# Metabolic_Enzyme_26_Gene_Sequence:
>1035 bp
ATGAGAGTGATTCGCGTGGGTACCCGCAAGAGCCAGCTTGCTCGCATACAGACGGACAGT
GTGGTGGCAACATTGAAAGCCTCGTACCCTGGCCTGCAGTTTGAAATCATTGCTATGTCC
ACCACAGGGGACAAGATTCTTGATACTGCACTCTCTAAGATTGGAGAGAAAAGCCTGTTT
ACCAAGGAGCTTGAACATGCCCTGGAGAAGAATGAAGTGGACCTGGTTGTTCACTCCTTG
AAGGACCTGCCCACTGTGCTTCCTCCTGGCTTCACCATCGGAGCCATCTGCAAGCGGGAA
AACCCTCATGATGCTGTTGTCTTTCACCCAAAATTTGTTGGGAAGACCCTAGAAACCCTG
CCAGAGAAGAGTGTGGTGGGAACCAGCTCCCTGCGAAGAGCAGCCCAGCTGCAGAGAAAG
TTCCCGCATCTGGAGTTCAGGAGTATTCGGGGAAACCTCAACACCCGGCTTCGGAAGCTG
GACGAGCAGCAGGAGTTCAGTGCCATCATCCTAGCAACAGCTGGCCTGCAGCGCATGGGC
TGGCACAACCGGGTTGGGCAGATCCTGCACCCTGAGGAATGCATGTATGCTGTGGGCCAG
GGGGCCTTGGGCGTGGAAGTGCGAGCCAAGGACCAGGACATCTTGGATCTGGTGGGTGTG
CTGCACGATCCCGAGACTCTGCTTCGCTGCATCGCTGAAAGGGCCTTCCTGAGGCACCTG
GAAGGAGGCTGCAGTGTGCCAGTAGCCGTGCATACAGCTATGAAGGATGGGCAACTGTAC
CTGACTGGAGGAGTCTGGAGTCTAGACGGCTCAGATAGCATACAAGAGACCATGCAGGCT
ACCATCCATGTCCCTGCCCAGCATGAAGATGGCCCTGAGGATGACCCACAGTTGGTAGGC
ATCACTGCTCGTAACATTCCACGAGGGCCCCAGTTGGCTGCCCAGAACTTGGGCATCAGC
CTGGCCAACTTGTTGCTGAGCAAAGGAGCCAAAACCATCCTGGATGTTGCACGGCAGCTT
AACGATGCCCATTAA

# Metabolic_Enzyme_26_GenBank_ID_Gene:
X04217

# Metabolic_Enzyme_26_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_26_Locus:
11q23.3

# Metabolic_Enzyme_26_SNPs:
rs1131488; rs1006195; rs589925; rs1784304; rs17075; rs616314; rs474201; rs11602791; rs28990985; rs494048; rs28990987; rs1799993; rs28990986; rs686624; rs592190; rs7479337; rs7952700; rs7952138; rs7938944; rs7942647; rs7924387; rs694328; rs11544979; rs34413634; rs762585; rs1051074; rs11544980; rs557253; rs28990984; rs1144041; rs1145225; rs35779756; rs2846282; rs34850583; rs2515706; rs4373940; rs7942009; rs7927752; rs11217149; rs549893; rs1799991; rs4272791; rs10618931; rs1799992; rs622846; rs12576807; rs1799994; rs34984714; rs11297272; rs12270687; rs34104555; rs4938625; rs11217148; rs4415775; rs35441227; rs35730078; rs34378932; rs34854067; rs603423; rs35182632; rs685241; rs1046374; rs1046375; rs1064180; rs1064193; rs10790282; rs1168568; rs1177562; rs1177563; rs1307145; rs15301; rs15818; rs1786687; rs1799997; rs2508948; rs2509049; rs2509704; rs2509850; rs28990980; rs3204606; rs34757931; rs35871971; rs36008744; rs3824944; rs4614; rs540261; rs565669; rs640603; rs643788; rs649870; rs7122226; rs7127212; rs7350; rs7759; rs8551

# Metabolic_Enzyme_26_General_References:
2875434; 3816774; 7916736; 3422427; 2609111; 7866402; 2243128; 1714233; 1496994; 1427766; 1301948; 8262523; 8401516; 8268934; 8270254; 8270256; 8081367; 7962538; 7757070; 8825929; 9199558; 9225970; 9654202; 9463797; 10494093; 10453740; 10502788; 10657149; 11030413; 10782018; 11013452

# Metabolic_Enzyme_26_References:
Not Available

# Metabolic_Enzyme_27_ID:
5952

# Metabolic_Enzyme_27_Name:
Protein-glutamine gamma-glutamyltransferase 5

# Metabolic_Enzyme_27_Synonyms:
Transglutaminase-5; TGase 5; Transglutaminase X; TGase X; TGX; TG(X

# Metabolic_Enzyme_27_Gene_Name:
TGM5

# Metabolic_Enzyme_27_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 5
MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFV
VETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIH
IDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCP
WNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNG
NWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVIT
NFDSGHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLD
ATPQEMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQKLHQDT
SSVGNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQP
SRPTSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFKDLK
VNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALG
EEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGS
GLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFAL


# Metabolic_Enzyme_27_Number_of_Residues:
720

# Metabolic_Enzyme_27_Molecular_Weight:
80778

# Metabolic_Enzyme_27_Theoretical_pI:
6.39

# Metabolic_Enzyme_27_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_27_General_Function:
Not Available

# Metabolic_Enzyme_27_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes

# Metabolic_Enzyme_27_Pathway:
Not Available

# Metabolic_Enzyme_27_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_27_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_27_Signals:
None

# Metabolic_Enzyme_27_Transmembrane_Regions:
None

# Metabolic_Enzyme_27_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_27_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_27_GenBank_ID_Protein:
2895530

# Metabolic_Enzyme_27_SwissProt_ID:
TGM5_HUMAN (O43548)

# Metabolic_Enzyme_27_swissprot_Name:
Not Available

# Metabolic_Enzyme_27_Genecard_id:
TGM5

# Metabolic_Enzyme_27_Geneatlas_id:
TGM5

# Metabolic_Enzyme_27_hgnc_id:
HGNC:11781

# Metabolic_Enzyme_27_PDB_ID:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_27_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_27_Subcellular_Location:
Cytoplasm. Note=Associated with intermediate filaments

# Metabolic_Enzyme_27_Gene_Sequence:
>2163 bp
ATGGCCCAAGGGCTAGAAGTGGCCCTCACAGACCTCCAGAGCTCCAGAAATAATGTGCGG
CACCACACGGAGGAGATCACTGTGGACCACCTGCTTGTTCGCCGGGGCCAGGCCTTCAAC
CTCACCCTGTACTTCAGGAACCGGAGCTTCCAGCCAGGCCTGGACAACATCATCTTCGTG
GTTGAAACTGGACCGCTGTCAGACCTGGCCTTGGGGACTCGGGCTGTGTTCAGCCTGGCA
CGCCATCACAGCCCCAGCCCCTGGATTGCCTGGCTGGAGACCAATGGGGCCACCTCCACA
GAGGTGAGCTTGTGCGCTCCTCCCACGGCGGCCGTGGGTCGGTACCTCTTGAAAATCCAC
ATCGACTCCTTCCAGGGGTCTGTGACGGCCTACCAGCTAGGGGAGTTCATCCTGCTTTTC
AATCCCTGGTGCCCAGAGGATGCTGTCTACTTGGACAGTGAACCCCAGAGGCAGGAGTAT
GTCATGAATGATTATGGCTTCATCTACCAAGGCAGCAAGAACTGGATCCGCCCATGTCCC
TGGAACTATGGACAGTTTGAAGACAAAATCATAGACATCTGCCTGAAGCTGCTAGACAAG
AGCCTGCACTTCCAGACTGACCCAGCCACAGACTGTGCTCTGCGGGGAAGCCCCGTCTAC
GTCAGCAGAGTGGTGTGTGCCATGATCAACAGCAATGATGATAATGGGGTGCTCAATGGA
AACTGGAGTGAGAATTACACAGACGGCGCCAACCCTGCGGAGTGGACGGGCAGCGTGGCC
ATCCTGAAGCAGTGGAACGCCACAGGCTGCCAGCCCGTGCGCTACGGGCAATGCTGGGTC
TTTGCTGCCGTCATGTGCACAGTGATGAGGTGTCTGGGGATCCCTACCCGTGTGATCACC
AACTTCGACTCTGGCCACGATACAGATGGAAACCTGATCATAGATGAGTATTATGACAAC
ACAGGCAGGATTTTGGGGAATAAGAAGAAGGATACTATCTGGAACTTCCATGTCTGGAAT
GAGTGCTGGATGGCCCGGAAGGATCTGCCCCCTGCATATGGAGGCTGGCAGGTGCTGGAC
GCCACACCTCAGGAGATGAGCAACGGCGTCTACTGCTGTGGCCCTGCCTCTGTCAGAGCC
ATCAAAGAAGGAGAAGTGGACCTGAACTATGACACGCCCTTTGTGTTTTCGATGGTGAAT
GCTGACTGCATGTCCTGGCTCGTCCAGGGAGGGAAGGAGCAGAAGCTTCACCAGGACACG
AGTTCTGTTGGCAATTTTATCAGCACAAAGAGCATCCAGAGTGACGAGCGGGATGACATC
ACAGAGAACTACAAGTATGAAGAAGGATCCCTCCAGGAGAGGCAGGTGTTTCTGAAGGCT
CTGCAGAAGCTGAAGGCTAGAAGCTTCCATGGCTCCCAAAGAGGAGCAGAGTTGCAACCT
TCCAGGCCCACATCACTGAGCCAGGACAGCCCTCGGAGCCTGCATACACCTTCCCTTCGA
CCCAGTGATGTGGTGCAAGTCTCCCTGAAATTCAAGCTGCTCGACCCGCCCAACATGGGC
CAGGATATATGCTTTGTCCTGCTGGCCCTCAACATGTCCTCCCAGTTCAAGGACCTCAAA
GTGAACCTGAGTGCCCAGTCTCTGCTGCACGATGGCAGCCCCCTGTCCCCATTCTGGCAG
GACACAGCGTTCATCACACTCTCTCCTAAAGAAGCAAAGACCTACCCCTGCAAAATCTCC
TATTCCCAGTACAGCCAGTACCTGTCAACAGACAAGCTGATCCGCATCAGTGCCCTGGGT
GAAGAGAAAAGCAGTCCTGAGAAAATCCTGGTGAACAAGATCATCACCTTATCTTATCCA
AGCATCACGATTAATGTTCTAGGAGCAGCCGTTGTGAACCAGCCACTCTCCATACAGGTG
ATATTTTCAAACCCCCTCTCGGAGCAGGTTGAGGACTGTGTGCTGACTGTGGAAGGAAGT
GGCCTCTTCAAGAAACAGCAGAAAGTCTTCCTTGGAGTCCTCAAACCCCAACACCAAGCA
AGCATCATTCTGGAGACCGTCCCCTTCAAGAGTGGACAAAGGCAGATCCAAGCTAATATG
AGAAGCAACAAGTTTAAGGACATTAAGGGTTACAGGAATGTTTATGTAGACTTTGCATTA
TAA

# Metabolic_Enzyme_27_GenBank_ID_Gene:
AF035960

# Metabolic_Enzyme_27_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_27_Locus:
15q15.2

# Metabolic_Enzyme_27_SNPs:
rs7171797; rs28756768; rs35985214; rs555001; rs34222269; rs502157; rs471122; rs542036; rs525403; rs574065; rs504417; rs545430; rs501884; rs579651; rs475261; rs530188; rs475227; rs493177; rs11070398; rs524547; rs16957507; rs825735; rs579178; rs16957511; rs573201; rs512431; rs572959; rs7183814; rs11855754; rs2241516; rs11853991; rs473016; rs16957502; rs565658; rs560134; rs3784267; rs7162827; rs12592795; rs3784268; rs564946; rs16957519; rs17778967; rs554001; rs573169; rs12909095; rs526292; rs16957521; rs752958; rs9652444; rs748404; rs11070397; rs7176183; rs513815; rs35578968; rs28465532; rs2241517; rs35025462; rs34973909; rs12901716; rs28544171; rs36041994; rs34646108; rs34092345; rs28705146; rs34978919; rs12911928; rs35535692; rs28444219; rs35852478; rs11430059; rs28505576; rs28670888; rs7162620; rs28669912; rs28445909; rs34922681; rs28393739; rs2412764; rs521681; rs12902267; rs34448188; rs28467179; rs34425851; rs34224662; rs34434330; rs12911633; rs13329564; rs34398515; rs34787120; rs34700701; rs34151953; rs34898259; rs2277527; rs34362734; rs35794888; rs11070396; rs12592725; rs12915538; rs2577057; rs28377745; rs35460126; rs35891068; rs3759788; rs473554; rs489964; rs491804; rs492743; rs493444; rs505249; rs530683; rs531910; rs537102; rs573774; rs6493080

# Metabolic_Enzyme_27_General_References:
9452468; 11390390

# Metabolic_Enzyme_27_References:
Not Available

# Metabolic_Enzyme_28_ID:
5953

# Metabolic_Enzyme_28_Name:
Glutaminase kidney isoform, mitochondrial precursor

# Metabolic_Enzyme_28_Synonyms:
GLS; L-glutamine amidohydrolase; K-glutaminase

# Metabolic_Enzyme_28_Gene_Name:
GLS

# Metabolic_Enzyme_28_Protein_Sequence:
>Glutaminase kidney isoform, mitochondrial precursor
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL

# Metabolic_Enzyme_28_Number_of_Residues:
669

# Metabolic_Enzyme_28_Molecular_Weight:
73462

# Metabolic_Enzyme_28_Theoretical_pI:
7.82

# Metabolic_Enzyme_28_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Function:  glutaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  glutamine family amino acid metabolism
Process:  glutamine metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_28_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_28_Specific_Function:
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine

# Metabolic_Enzyme_28_Pathway:
map00251  Glutamate metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_28_Reaction:
L-glutamine + H2O = L-glutamate + NH3

# Metabolic_Enzyme_28_Pfam_Domain_Function:
PF00023:Ank;
PF04960:Glutaminase

# Metabolic_Enzyme_28_Signals:
1-23

# Metabolic_Enzyme_28_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_28_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_28_EC_Link:
EC 3.5.1.2

# Metabolic_Enzyme_28_GenBank_ID_Protein:
5690372

# Metabolic_Enzyme_28_SwissProt_ID:
GLSK_HUMAN (O94925)

# Metabolic_Enzyme_28_swissprot_Name:
Not Available

# Metabolic_Enzyme_28_Genecard_id:
GLS

# Metabolic_Enzyme_28_Geneatlas_id:
GLS

# Metabolic_Enzyme_28_hgnc_id:
HGNC:4331

# Metabolic_Enzyme_28_PDB_ID:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_28_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_28_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_28_Gene_Sequence:
>1797 bp
ATGATGCGGCTGCGAGGCTCGGGGATGCTGCGGGACCTGCTCCTGCGGTCGCCCGCCGGC
GTGAGCGNGACTCTGCGGCGGGCACAGCCCTTGGTCACCCTGTGCCGGCGTCCCCGAGGC
GGGGGACGGCCGGCCGCGGGCCCGGCTGCCGCCGCGCGACTCCACCCGTGGTGGGGCGGG
GGCGGCTGGCCGGCGGAGCCCCTCGCGCGGGGCCTGTCCAGCTCTCCTTCGGAGATCTTG
CAGGAGCTGGGCAAGGGGAGCACGCATCCCCAGCCCGGGGTGTCGCCACCCGCTGCCCCG
GCGGCGCCCGGCCCCAAGGACGGCCCCGGGGAGACGGACGCGTTTGGCAACAGCGAGGGC
AAAGAGCTGGTGGCCTCAGGTGAAAACAAAATAAAACAGGGTCTGTTACCTAGCTTGGAA
GATTTGCTGTTCTATACAATTGCTGAAGGACAAGAGAAAATACCTGTTCATAAATTTATT
ACAGCACTCAAATCTACAGGATTGCGAACGTCTGATCCCAGGTTGAAAGAGTGTATGGAT
ATGTTAAGATTAACTCTTCAAACAACATCAGATGGTGTCATGCTAGACAAAGATCTTTTT
AAAAAATGTGTTCAGAGCAACATTGTTTTGTTGACACAAGCATTTAGAAGAAAGTTTGTG
ATTCCTGACTTTATGTCTTTTACCTCACACATTGATGAGTTATATGAAAGTGCTAAAAAG
CAGTCTGGAGGAAAGGTTGCAGATTATATTCCTCAACTGGCCAAATTCAGTCCCGATTTG
TGGGGTGTGTCTGTTTGTACAGCAGATGGACAGAGGCATTCTACTGGAGATACCAAAGTT
CCCTTCTGTCTTCAGTCCTGTGTAAAACCTTTGAAATATGCCATTGCTGTTAATGATCTT
GGAACTGAATATGTGCATCGATATGTTGGAAAAGAGCCGAGTGGACTAAGATTCAACAAA
CTATTTTTGAATGAAGATGATAAACCACATAATCCTATGGTAAATGCTGGAGCAATTGTT
GTGACTTCACTAATAAAGCAAGGAGTAAATAATGCTGAAAAATTTGACTATGTCATGCAG
TTTTTGAATAAGATGGCTGGTAATGAATATGTTGGATTCAGTAATGCAACGTTTCAGTCT
GAAAGAGAAAGTGGAGATCGAAATTTTGCAATAGGATATTACTTAAAAGAAAAGAAGTGT
TTTCCAGAAGGCACAGACATGGTTGGTATATTAGACTTCTACTTCCAGCTGTGCTCCATT
GAAGTGACTTGTGAATCAGCCAGTGTGATGGCTGCGACACTGGCTAATGGTGGTTTCTGC
CCAATTACTGGTGAAAGAGTACTGAGCCCTGAAGCAGTTCGAAATACATTGAGTTTGATG
CATTCCTGTGGCATGTATGACTTCTCAGGGCAGTTTGCTTTCCATGTTGGTCTTCCTGCA
AAATCTGGAGTTGCTGGGGGCATTCTTTTAGTTGTCCCCAATGTTATGGGTATGATGTGC
TGGTCTCCTCCTCTGGATAAGATGGGCAACAGTGTTAAGGGAATTCACTTTTGTCACGAT
CTTGTTTCTCTGTGTAATTTCCATAACTATGATAATTTGAGACACTTTGCAAAAAAACTT
GATCCTCGAAGAGAAGGTGGTGATCAAAGGCATTCCTTTGGACCATTGGACTATGAAAGT
CTCCAACAAGAACTTGCTTTAAAAGAGACAGTATGGAAAAAAGTGTCACCTGAGTCAAAT
GAGGACATCTCTACAACTGTAGTATATAGAATGGAAAGTCTGGGAGAGAAAAGCTAA

# Metabolic_Enzyme_28_GenBank_ID_Gene:
AF158555

# Metabolic_Enzyme_28_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_28_Locus:
2q32-q34

# Metabolic_Enzyme_28_SNPs:
rs3732211; rs1168; rs1546646; rs3088307; rs1546647; rs10437; rs1546648; rs13035504; rs16833113; rs2883582; rs1921907; rs883844; rs1921914; rs867637; rs2203715; rs984610; rs11691127; rs1921915; rs4853454; rs1921912; rs3771316; rs4853531; rs6758866; rs6434429; rs6434430; rs2355570; rs4853530; rs11692579; rs1517356; rs4853528; rs6743496; rs932170; rs1921913; rs3771311; rs17815942; rs1517355; rs16833049; rs3771308; rs3771310; rs12998878; rs3771304; rs16833031; rs17748089; rs10931476; rs11683679; rs1607187; rs11693788; rs12987113; rs3771313; rs12185688; rs13001395; rs7564529; rs4597558; rs1517354; rs6713444; rs6721631; rs13384728; rs10497710; rs3732212; rs2355571; rs2883713; rs16833050; rs2108818; rs11894259; rs11681912; rs16833073; rs16833053; rs16833056; rs1033249; rs13000464; rs16833092; rs16833069; rs3087950; rs13414554; rs16833067; rs12992618; rs11674731; rs11677838; rs3771307; rs16833042; rs6712504; rs11688967; rs11889157; rs3771314; rs4853529; rs16833040; rs11675981; rs16833020; rs12467368; rs1921909; rs3755313; rs16833035; rs35890674; rs1801893; rs17853842; rs3199238; rs3207596; rs1136115; rs1058590; rs1136112; rs1136107; rs1136111; rs1058592; rs1801892; rs1058589; rs3207595; rs3199237; rs3207597; rs1136114; rs1058591; rs1136113; rs3836129; rs34962483; rs28930678; rs11268964; rs11272113; rs34913321; rs34693346; rs10645506; rs34009071; rs34646339; rs13024969; rs35753740; rs12620987; rs33957014; rs34322022; rs11386437; rs5837213; rs34719838; rs11306120; rs33998570; rs34470725; rs11547780; rs36064959; rs11547781; rs34687743; rs3217036; rs6751852; rs11886120; rs34219109; rs34101296; rs10198061; rs6713807; rs7586514; rs11368612; rs5837211; rs35376983; rs11299475; rs34298947; rs35621182; rs34999321; rs1045208; rs34287390; rs34660567; rs10529560; rs35016708; rs6729740; rs34844301; rs3771309; rs34841385; rs34809982; rs3821234; rs13399044; rs34359726; rs35122426; rs7602927; rs4511752; rs4853452; rs10532100; rs35048130; rs35360323; rs36013374; rs10623498; rs34798536; rs3215259; rs34801561; rs36074537; rs33972110; rs36025643; rs2292790; rs35915280; rs34900059; rs10590551; rs35272604; rs2355572; rs36008676; rs35542564; rs34419675; rs13414648; rs35034516; rs34717146; rs11363248; rs35910874; rs5837212; rs10716407; rs13391964; rs35968676; rs35712414; rs11377483; rs2178605; rs3771312; rs34752857; rs33958764; rs13012566; rs2292792; rs34312179; rs13017410; rs34466013; rs3039186; rs11370315; rs3036651; rs41270235; rs34914533; rs35453613; rs12990256; rs4853453; rs10221634; rs3771303; rs35957111; rs34053475; rs35745438; rs34321717; rs35868744; rs34901974; rs11547782; rs13414269; rs10665259; rs34793584; rs13000734; rs2292791; rs7558585; rs17816440; rs16833121; rs28362510; rs12997127; rs35314646; rs11305; rs11687659; rs11690599; rs11885168; rs11894425; rs11899865; rs12468579; rs12693589; rs12987796; rs13395505; rs1400657; rs16824035; rs16833123; rs16833126; rs17748980; rs1914407; rs1914408; rs2066793; rs2066803; rs2204859; rs35364817; rs3771300; rs4853526; rs4853533; rs6718902; rs6734110; rs7575823; rs9789700

# Metabolic_Enzyme_28_General_References:
11015561; 10048485; 10719215

# Metabolic_Enzyme_28_References:
Not Available

# Metabolic_Enzyme_29_ID:
5954

# Metabolic_Enzyme_29_Name:
Protein-glutamine gamma-glutamyltransferase 4

# Metabolic_Enzyme_29_Synonyms:
Transglutaminase-4; TGase-4; Prostate transglutaminase; TGP; TG(P; Prostate-specific transglutaminase; Fibrinoligase

# Metabolic_Enzyme_29_Gene_Name:
TGM4

# Metabolic_Enzyme_29_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 4
MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL
EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV
KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN
FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG
TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER
NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV
FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN
ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD
DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT
LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG
QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK
KFIVKLSSKQVKEINAQKIVLITK

# Metabolic_Enzyme_29_Number_of_Residues:
684

# Metabolic_Enzyme_29_Molecular_Weight:
77146

# Metabolic_Enzyme_29_Theoretical_pI:
6.75

# Metabolic_Enzyme_29_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_29_General_Function:
Not Available

# Metabolic_Enzyme_29_Specific_Function:
Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract

# Metabolic_Enzyme_29_Pathway:
Not Available

# Metabolic_Enzyme_29_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_29_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_29_Signals:
None

# Metabolic_Enzyme_29_Transmembrane_Regions:
None

# Metabolic_Enzyme_29_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_29_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_29_GenBank_ID_Protein:
2766556

# Metabolic_Enzyme_29_SwissProt_ID:
TGM4_HUMAN (P49221)

# Metabolic_Enzyme_29_swissprot_Name:
Not Available

# Metabolic_Enzyme_29_Genecard_id:
TGM4

# Metabolic_Enzyme_29_Geneatlas_id:
TGM4

# Metabolic_Enzyme_29_hgnc_id:
HGNC:11780

# Metabolic_Enzyme_29_PDB_ID:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_29_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_29_Subcellular_Location:
Not Available

# Metabolic_Enzyme_29_Gene_Sequence:
>2055 bp
ATGATGGATGCATCAAAAGAGCTGCAAGTTCTCCACATTGACTTCTTGAATCAGGACAAC
GCCGTTTCTCACCACACATGGGAGTTCCAAACGAGCAGTCCTGTGTTCCGGCGAGGACAG
GTGTTTCACCTGCGGCTGGTGCTGAACCAGCCCCTACAATCCTACCACCAACTGAAACTG
GAATTCAGCACAGGGCCGAATCCTAGCATCGCCAAACACACCCTGGTGGTGCTCGACCCG
AGGACGCCCTCAGACCACTACAACTGGCAGGCAACCCTTCAAAATGAGTCTGGCAAAGAG
GTCACAGTGGCTGTCACCAGTTCCCCCAATGCCATCCTGGGCAAGTACCAACTAAACGTG
AAAACTGGAAACCACATCCTTAAGTCTGAAGAAAACATCCTATACCTTCTCTTCAACCCA
TGGTGTAAAGAGGACATGGTTTTCATGCCTGATGAGGACGAGCGCAAAGAGTACATCCTC
AATGACACGGGCTGCCATTACGTGGGGGCTGCCAGAAGTATCAAATGCAAACCCTGGAAC
TTTGGTCAGTTTGAGAAAAATGTCCTGGACTGCTGCATTTCCCTGCTGACTGAGAGCTCC
CTCAAGCCCACAGATAGGAGGGACCCCGTGCTGGTGTGCAGGGCCATGTGTGCTATGATG
AGCTTTGAGAAAGGCCAGGGCGTGCTCATTGGGAATTGGACTGGGGACTACGAAGGTGGC
ACAGCCCCATACAAGTGGACAGGCAGTGCCCCGATCCTGCAGCAGTACTACAACACGAAG
CAGGCTGTGTGCTTTGGCCAGTGCTGGGTGTTTGCTGGGATCCTGACTACAGTGCTGAGA
GCGTTGGGCATCCCAGCACGCAGTGTGACAGGCTTCGATTCAGCTCACGACACAGAAAGG
AACCTCACGGTGGACACCTATGTGAATGAGAATGGCGAGAAAATCACCAGTATGACCCAC
GACTCTGTCTGGAATTTCCATGTGTGGACGGATGCCTGGATGAAGCGACCGGATCTGCCC
AAGGGCTACGACGGCTGGCAGGCTGTGGACGCAACGCCGCAGGAGCGAAGCCAGGGTGTC
TTCTGCTGTGGGCCATCACCACTGACCGCCATCCGCAAAGGTGACATCTTTATTGTCTAT
GACACCAGATTCGTCTTCTCAGAAGTGAATGGTGACAGGCTCATCTGGTTGGTGAAGATG
GTGAATGGGCAGGAGGAGTTACACGTAATTTCAATGGAGACCACAAGCATCGGGAAAAAC
ATCAGCACCAAGGCAGTGGGCCAAGACAGGCGGAGAGATATCACCTATGAGTACAAGTAT
CCAGAAGGCTCCTCTGAGGAGAGGCAGGTCATGGATCATGCCTTCCTCCTTCTCAGTTCT
GAGAGGGAGCACAGACGACCTGTAAAAGAGAACTTTCTTCACATGTCGGTACAATCAGAT
GATGTGCTGCTGGGAAACTCTGTTAATTTCACCGTGATTCTTAAAAGGAAGACCGCTGCC
CTACAGAATGTCAACATCTTGGGCTCCTTTGAACTACAGTTGTACACTGGCAAGAAGATG
GCAAAACTGTGTGACCTCAATAAGACCTCGCAGATCCAAGGTCAAGTATCAGAAGTGACT
CTGACCTTGGACTCCAAGACCTACATCAACAGCCTGGCTATATTAGATGATGAGCCAGTT
ATCAGAGGTTTCATCATTGCGGAAATTGTGGAGTCTAAGGAAATCATGGCCTCTGAAGTA
TTCACGTCTTTCCAGTACCCTGAGTTCTCTATAGAGTTGCCTAACACAGGCAGAATTGGC
CAGCTACTTGTCTGCAATTGTATCTTCAAGAATACCCTGGCCATCCCTTTGACTGACGTC
AAGTTCTCTTTGGAAAGCCTGGGCATCTCCTCACTACAGACCTCTGACCATGGGACGGTG
CAGCCTGGTGAGACCATCCAATCCCAAATAAAATGCACCCCAATAAAAACTGGACCCAAG
AAATTTATCGTCAAGTTAAGTTCCAAACAAGTGAAAGAGATTAATGCTCAGAAGATTGTT
CTCATCACCAAGTAG

# Metabolic_Enzyme_29_GenBank_ID_Gene:
L34840

# Metabolic_Enzyme_29_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_29_Locus:
3p22-p21.33

# Metabolic_Enzyme_29_SNPs:
rs1995641; rs13326552; rs2271087; rs9818345; rs9876921; rs3749195; rs17077022; rs937838; rs1395388; rs1995640; rs34772357; rs34630572; rs34547377; rs1007; rs7642831; rs937837; rs1520082; rs1464296; rs4683005; rs1354767; rs13320377; rs4622937; rs6777798; rs6768893; rs6804037; rs1354768; rs6766025; rs6441872; rs1532898; rs937835; rs2242476; rs6784318; rs952662; rs4683007; rs3828354; rs4683001; rs6789626; rs2011446; rs12632450; rs4682756; rs9832678; rs9683370; rs9829341; rs6778676; rs1995639; rs937833; rs11916548; rs12634217; rs7340548; rs9823957; rs11130037; rs4683006; rs9683355; rs2089341; rs937836; rs4683009; rs4408902; rs4683010; rs4683000; rs7612574; rs13076123; rs12497045; rs4682759; rs9942026; rs7621750; rs9833819; rs2242475; rs3749194; rs4683004; rs9816639; rs1995638; rs1109412; rs2089340; rs877827; rs17076998; rs2036618; rs4683003; rs17077029; rs17077036; rs4683002; rs9823021; rs9828821; rs12632251; rs2135532; rs17077039; rs9811595; rs17850130; rs36081973; rs17850131; rs17850132; rs6650899; rs28633171; rs11707176; rs6441869; rs10620922; rs9834497; rs9822927; rs5848716; rs10580461; rs9942073; rs13072935; rs11719342; rs3082589; rs41289594; rs5848714; rs4682755; rs34004254; rs34569834; rs10531764; rs34199221; rs2372834; rs6765789; rs2372833; rs35425085; rs11369371; rs35781374; rs28666966; rs28705387; rs5848718; rs9871653; rs7373845; rs34936453; rs4683008; rs10614838; rs9836448; rs2372832; rs11387960; rs10622920; rs11708759; rs33981546; rs34205309; rs3804578; rs34193683; rs35054781; rs11928928; rs9798982; rs5848717; rs34801426; rs34860847; rs34268460; rs9811537; rs35980364; rs10429; rs1046827; rs12495512; rs12631990; rs1506659; rs1553606; rs17631716; rs1979946; rs2372849; rs2888422; rs34883405; rs3749193; rs6622; rs7621143; rs7622843; rs7644978; rs7645129; rs870950; rs937832; rs9826883; rs9848333; rs9857496; rs9863165

# Metabolic_Enzyme_29_General_References:
7916568; 8645175

# Metabolic_Enzyme_29_References:
Not Available

# Metabolic_Enzyme_30_ID:
5955

# Metabolic_Enzyme_30_Name:
Protein-glutamine gamma-glutamyltransferase K

# Metabolic_Enzyme_30_Synonyms:
Transglutaminase K; TGase K; TGK; TG(K; Transglutaminase-1; Epidermal TGase

# Metabolic_Enzyme_30_Gene_Name:
TGM1

# Metabolic_Enzyme_30_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 
KMMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADD
DWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLS
SRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGT
HVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDP
RNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLD
ACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSV
EILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDE
NMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVES
IKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMRED
ITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVM
LINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHL
VDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPV
TLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVH
GVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA

# Metabolic_Enzyme_30_Number_of_Residues:
817

# Metabolic_Enzyme_30_Molecular_Weight:
89788

# Metabolic_Enzyme_30_Theoretical_pI:
5.92

# Metabolic_Enzyme_30_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_30_General_Function:
Not Available

# Metabolic_Enzyme_30_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum

# Metabolic_Enzyme_30_Pathway:
Not Available

# Metabolic_Enzyme_30_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_30_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_30_Signals:
None

# Metabolic_Enzyme_30_Transmembrane_Regions:
None

# Metabolic_Enzyme_30_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_30_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_30_GenBank_ID_Protein:
1256959

# Metabolic_Enzyme_30_SwissProt_ID:
TGM1_HUMAN (P22735)

# Metabolic_Enzyme_30_swissprot_Name:
Not Available

# Metabolic_Enzyme_30_Genecard_id:
TGM1

# Metabolic_Enzyme_30_Geneatlas_id:
TGM1

# Metabolic_Enzyme_30_hgnc_id:
HGNC:11777

# Metabolic_Enzyme_30_PDB_ID:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_30_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_30_Subcellular_Location:
Membrane; lipid-anchor

# Metabolic_Enzyme_30_Gene_Sequence:
>2454 bp
ATGATGGATGGGCCACGTTCCGATGTGGGCCGTTGGGGTGGCAACCCCTTGCAGCCCCCT
ACCACGCCATCTCCAGAGCCAGAGCCAGAGCCAGACGGACGCTCTCGCAGAGGAGGAGGC
CGTTCCTTCTGGGCTCGCTGCTGTGGCTGCTGTTCATGCCGAAATGCGGCAGATGACGAC
TGGGGACCTGAACCCTCTGACTCCAGGGGTCGAGGGTCCAGCTCTGGCACTCGAAGACCT
GGCTCCCGGGGCTCAGACTCCCGCCGGCCTGTATCCCGGGGCAGCGGTGTCAATGCAGCT
GGAGATGGCACCATCCGAGAGGGCATGCTAGTAGTGAACGGTGTGGACTTGCTGAGCTCG
CGCTCGGACCAGAACCGCCGAGAGCACCACACAGACGAGTATGAGTACGACGAGCTGATA
GTGCGCCGCGGGCAGCCTTTCCATATGCTCCTCCTCCTGTCCCGGACCTATGAATCCTCT
GATCGCATCACCCTTGAGTTACTCATCGGAAACAACCCCGAGGTGGGCAAGGGCACGCAC
GTGATCATCCCAGTGGGCAAGGGGGGCAGTGGAGGCTGGAAAGCCCAGGTGGTCAAGGCC
AGTGGGCAGAATCTGAACCTGCGGGTCCACACTTCCCCCAACGCCATCATCGGCAAGTTT
CAGTTCACAGTCCGCACACAATCAGACGCTGGGGAGTTCCAGTTGCCCTTTGACCCCCGC
AATGAGATCTACATCCTCTTCAACCCCTGGTGCCCAGAGGACATTGTGTACGTGGACCAT
GAGGATTGGCGGCAGGAGTATGTTCTTAATGAGTCTGGGAGAATTTACTACGGGACCGAA
GCACAGATTGGTGAGCGGACCTGGAACTACGGCCAGTTTGACCACGGGGTGCTGGATGCC
TGCTTATACATCCTGGACCGGCGGGGGATGCCATATGGAGGCCGTGGAGACCCAGTCAAT
GTCTCCCGGGTCATCTCTGCCATGGTGAACTCCCTGGATGACAATGGAGTCCTGATTGGG
AACTGGTCTGGTGATTACTCCCGAGGCACCAACCCATCAGCGTGGGTGGGCAGCGTGGAG
ATCCTGCTTAGCTACCTACGCACGGGATATTCCGTCCCCTATGGCCAGTGCTGGGTCTTT
GCTGGCGTGACCACCACAGTGCTGCGCTGCCTGGGTCTGGCCACCCGTACTGTCACCAAC
TTCAACTCCGCCCACGACACAGACACATCCCTTACCATGGACATCTACTTCGACGAGAAC
ATGAAGCCCCTGGAGCACCTGAACCATGATTCTGTCTGGAACTTCCATGTGTGGAACGAC
TGCTGGATGAAGAGGCCGGATCTGCCCTCGGGCTTTGATGGGTGGCAGGTGGTGGATGCC
ACACCCCAAGAGACTAGCAGTGGCATCTTCTGCTGCGGCCCCTGCTCTGTGGAGTCCATC
AAGAATGGCCTGGTCTACATGAAGTACGACACGCCTTTCATTTTTGCTGAGGTGAATAGT
GACAAGGTGTACTGGCAGCGGCAGGATGATGGCAGCTTCAAGATTGTTTATGTGGAGGAG
AAGGCCATCGGCACACTCATTGTCACAAAGGCCATCAGCTCCAACATGCGGGAGGACATC
ACCTACCTCTATAAGCACCCAGAAGGCTCAGACGCAGAGCGGAAGGCAGTAGAGACAGCA
GCAGCCCACGGCAGCAAACCCAATGTGTATGCCAACCGGGGCTCAGCGGAGGATGTGGCC
ATGCAGGTGGAGGCACAGGACGCGGTGATGGGGCAGGATCTGATGGTCTCTGTGATGCTG
ATCAATCACAGCAGCAGCCGCCGCACAGTGAAACTGCACCTCTACCTCTCAGTCACTTTC
TATACTGGTGTCAGTGGTACCATCTTCAAGGAGACCAAGAAGGAAGTGGAGCTGGCACCA
GGGGCCTCGGACCGTGTGACCATGCCAGTGGCCTACAAGGAATACCGGCCCCATCTTGTG
GACCAGGGGGCCATGCTGCTCAATGTCTCAGGCCACGTCAAGGAGAGCGGGCAGGTGCTG
GCCAAGCAGCACACCTTCCGTCTGCGCACCCCAGACCTCTCCCTCACGTTACTGGGAGCA
GCAGTGGTTGGCCAGGAGTGTGAAGTACAGATTGTCTTCAAGAACCCCCTTCCCGTCACC
CTCACCAATGTCGTCTTCCGGCTCGAAGGCTCTGGGTTACAGAGGCCCAAGATCCTCAAC
GTTGGGGACATTGGAGGCAATGAAACAGTGACACTGCGCCAGTCGTTTGTGCCTGTGCGA
CCAGGCCCCCGCCAGCTCATTGCCAGCTTGGACAGCCCACAGCTCTCCCAGGTGCACGGT
GTCATCCAGGTGGATGTGGCCCCAGCCCCTGGGGATGGGGGCTTCTTCTCAGACGCTGGA
GGTGACAGTCACTTAGGAGAGACCATCCCTATGGCATCTCGAGGTGGAGCTTAG

# Metabolic_Enzyme_30_GenBank_ID_Gene:
M98447

# Metabolic_Enzyme_30_Chromosome_Location:
Chromosome:14

# Metabolic_Enzyme_30_Locus:
14q11.2

# Metabolic_Enzyme_30_SNPs:
rs2228337; rs35312232; rs35926651; rs2229464; rs2229462; rs17102410; rs35755034; rs41295336; rs1126432; rs2273302; rs2229463; rs17256811; rs2748513; rs2748531; rs7151201; rs2273303; rs1950494; rs2855098; rs8193032; rs35692401; rs8193033; rs2277486; rs34597632; rs3783442; rs17794788; rs2855094; rs17102378; rs17102396; rs17102408; rs41293786; rs2256989; rs36114057; rs41293818; rs41293828; rs8193034; rs41293792; rs41295332; rs41293834; rs34955494; rs3742506; rs2277485; rs2748516; rs41293944; rs41293838; rs41293814; rs34987032; rs4982880; rs41293956; rs41293788; rs4982881; rs2748525; rs4982882; rs41293836; rs7158744; rs941505; rs11625433; rs2273301; rs3814814; rs41295322; rs41294732; rs41294728; rs3814813; rs41294730; rs941504; rs7147300; rs41293794; rs2855111; rs2748529; rs41295338; rs2855009; rs2855105; rs2855110; rs2855109; rs2748528; rs2228336; rs41295340; rs41295444; rs2855005; rs8193031; rs2855112; rs2854998; rs2144486; rs2855007; rs2748512; rs8003142; rs2748536; rs8193035; rs2748514; rs41294726; rs2855107; rs34774258; rs2855092; rs41293784; rs2748517; rs41293840; rs2855012; rs2855011; rs41293796; rs41293826; rs2748532; rs41293948; rs2854996; rs2855101; rs7147837; rs41293810; rs41293950; rs2855097; rs8012492; rs3832938; rs2748520; rs41295330; rs41293798; rs35902378; rs2748527; rs2748530; rs2855106; rs2855001; rs2748533; rs2855010; rs41295342; rs2855093; rs34038141; rs2854995; rs2748523; rs41293952; rs35813315; rs2855102; rs41293806; rs41293808; rs41293822; rs12435893; rs41293780; rs35367573; rs2855099; rs41293816; rs2748534; rs2855002; rs41293830; rs41295334; rs41293782; rs2748519; rs2748535; rs41293842; rs41293800; rs2748524; rs3216749; rs2855103; rs2855015; rs2855095; rs41293790; rs2855004; rs2855008; rs2748518; rs35101954; rs2748515; rs2748521; rs2854994; rs1950493; rs41293954; rs2855108; rs2855003; rs41293802; rs2748526; rs41293832; rs41293812; rs2855013; rs34794036; rs4456423; rs11432317; rs41293804; rs2855014; rs2855096; rs2854997; rs2855113; rs41293824; rs2855104; rs2855091; rs2854993; rs35504574; rs2748522; rs41293820; rs41293946; rs3841476; rs34714373; rs41295328; rs2075530; rs41295324; rs8004517; rs2332229; rs33931317; rs41295326; rs34282188; rs34491912; rs10141326; rs10148135; rs1050589; rs11626191; rs11844422; rs12883582; rs12886219; rs12897704; rs14193; rs17102311; rs17102313; rs2180196; rs2281473; rs2295311; rs2295313; rs2295314; rs2295315; rs2877612; rs34113897; rs34861984; rs34973999; rs3818161; rs3825585; rs4982877; rs6573652; rs7145550; rs729421; rs766601; rs766602; rs941503

# Metabolic_Enzyme_30_General_References:
1346394; 1670769; 1979171; 1673840; 1350092; 1381356; 1351505; 7824952; 7773290; 9326318; 11251583

# Metabolic_Enzyme_30_References:
Not Available

# Metabolic_Enzyme_31_ID:
5956

# Metabolic_Enzyme_31_Name:
Histidine ammonia-lyase

# Metabolic_Enzyme_31_Synonyms:
Histidase

# Metabolic_Enzyme_31_Gene_Name:
HAL

# Metabolic_Enzyme_31_Protein_Sequence:
>Histidine ammonialyase
MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKG
LGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDR
LTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPI
NKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNAS
CLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPK
EGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRG
QIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITT
ELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLS
ELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAAR
KALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDI
EAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL

# Metabolic_Enzyme_31_Number_of_Residues:
657

# Metabolic_Enzyme_31_Molecular_Weight:
72698

# Metabolic_Enzyme_31_Theoretical_pI:
6.95

# Metabolic_Enzyme_31_GO_Classification:
>>>
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  acid-ammonia (or amide) ligase activity
Function:  ammonia ligase activity
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  ammonia-lyase activity
Function:  histidine ammonia-lyase activity
 ||
>>>
Process:  biosynthesis
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  histidine family amino acid metabolism
Process:  histidine metabolism
Process:  histidine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_31_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_31_Specific_Function:
L-histidine = urocanate + NH(3)

# Metabolic_Enzyme_31_Pathway:
map00340  Histidine metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_31_Reaction:
L-histidine = urocanate + NH3

# Metabolic_Enzyme_31_Pfam_Domain_Function:
PF00221:PAL

# Metabolic_Enzyme_31_Signals:
None

# Metabolic_Enzyme_31_Transmembrane_Regions:
None

# Metabolic_Enzyme_31_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_31_EC_Link:
EC 4.3.1.3

# Metabolic_Enzyme_31_GenBank_ID_Protein:
451210

# Metabolic_Enzyme_31_SwissProt_ID:
HUTH_HUMAN (P42357)

# Metabolic_Enzyme_31_swissprot_Name:
Not Available

# Metabolic_Enzyme_31_Genecard_id:
HAL

# Metabolic_Enzyme_31_Geneatlas_id:
HAL

# Metabolic_Enzyme_31_hgnc_id:
HGNC:4806

# Metabolic_Enzyme_31_PDB_ID:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_31_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_31_Subcellular_Location:
Not Available

# Metabolic_Enzyme_31_Gene_Sequence:
>1974 bp
ATGCCCAGATACACGGTGCACGTACGTGGGGAATGGCTGGCAGTGCCCTGCCAGGACGCG
CAGCTCACTGTGGGCTGGCTGGGCCGGGAGGCCGTGAGGCGCTATATCAAGAATAAGCCC
GACAATGGTGGCTTCACCTCCGTGGATGACGCGCACTTCCTTGTGCGCCGGTGCAAGGGC
CTGGGCCTGCTGGACAACGAGGACCGGCTCGAGGTGGCCCTAGAGAACAACGAGTTCGTG
GAAGTGGTTATAGAGGGTGATGCCATGTCTCCTGACTTCATTCCATCTCAACCAGAAGGA
GTTTATCTATACAGCAAGTACCGGGAGCCTGAAAAGTACATCGAGTTAGATGGAGACCGT
CTGACCACGGAGGATCTGGTCAACTTGGGAAAGGGACGCTACAAAATAAAGCTCACCCCA
ACAGCTGAGAAGAGGGTGCAGAAATCCAGGGAGGTCATAGATAGCATCATAAAAGAGAAA
ACAGTTGTTTACGGTATTACTACAGGTTTTGGGAAATTTGCCAGAACTGTAATTCCTATC
AATAAGCTACAGGAGCTTCAGGTCAACTTAGTACGCTCACATTCTTCAGGTGTTGGGAAA
CCACTAAGTCCTGAGAGGTGTCGGATGCTCTTGGCTTTAAGGATCAATGTCTTAGCCAAA
GGATACAGTGGCATTTCCCTGGAGACCCTCAAACAAGTCATAGAAATGTTTAATGCCTCC
TGCCTGCCCTATGTCCCAGAGAAAGGAACCGTTGGTGCCAGTGGAGACCTTGCCCCACTC
TCTCATCTTGCTCTTGGGCTAGTTGGAGAAGGGAAGATGTGGTCTCCGAAGAGTGGCTGG
GCTGATGCTAAATACGTGCTAGAAGCCCATGGATTGAAACCAGTTATTTTAAAACCAAAA
GAGGGCCTGGCACTCATCAATGGGACGCAGATGATCACATCCCTGGGCTGTGAAGCTGTA
GAGCGAGCCAGTGCTATTGCACGGCAGGCTGACATTGTGGCAGCCCTGACCCTTGAGGTG
CTGAAGGGCACCACCAAAGCCTTTGACACTGACATTCATGCTCTTCGACCTCACCGTGGG
CAAATTGAAGTTGCTTTTCGGTTTCGGTCACTCTTGGACTCAGATCACCACCCATCAGAA
ATAGCAGAGAGTCACAGGTTCTGTGATCGCGTCCAGGATGCATACACCTTGCGCTGCTGT
CCACAGGTCCATGGTGTGGTGAATGATACAATAGCATTTGTGAAGAACATCATTACCACA
GAACTGAACAGCGCAACAGATAATCCTATGGTCTTTGCCAATAGGGGAGAGACAGTTTCT
GGAGGAAACTTCCATGGTGAATACCCAGCCAAAGCCCTAGACTACTTGGCCATTGGCATC
CATGAACTTGCTGCAATCAGTGAGAGAAGAATCGAGCGGCTCTGCAATCCCTCCCTCAGT
GAGCTGCCTGCCTTCCTGGTGGCTGAAGGTGGTCTGAACTCTGGGTTCATGATAGCTCAC
TGCACGGCAGCAGCCCTTGTTTCTGAGAACAAGGCTCTGTGCCATCCCTCGTCTGTTGAC
TCCCTCTCCACCAGCGCAGCCACGGAGGACCACGTCTCCATGGGAGGATGGGCAGCAAGG
AAAGCCCTCAGGGTCATCGAGCATGTGGAGCAAGTGCTGGCCATCGAGCTCCTTGCAGCC
TGCCAGGGCATAGAGTTTCTACGTCCCCTGAAAACAACCACTCCGCTGGAGAAGGTCTAT
GACCTGGTGCGCTCTGTTGTAAGGCCCTGGATAAAAGATCGCTTCATGGCCCCGGACATC
GAGGCAGCCCACAGGCTGCTCCTGGAGCAGAAGGTTTGGGAAGTAGCTGCTCCATACATT
GAAAAATACAGAATGGAGCATATTCCAGAATCAAGACCTCTTTCTCCAACAGCCTTTTCA
CTGCAATTTCTGCACAAGAAATCCACCAAAATCCCGGAGTCTGAGGACCTTTAA

# Metabolic_Enzyme_31_GenBank_ID_Gene:
D16626

# Metabolic_Enzyme_31_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_31_Locus:
12q22-q24.1

# Metabolic_Enzyme_31_SNPs:
rs7297245; rs17024973; rs2302628; rs11108364; rs36014288; rs2230885; rs11108369; rs2268520; rs2302629; rs2268518; rs10859996; rs11108366; rs2072511; rs2268517; rs3764038; rs11108368; rs2300560; rs3819817; rs10745747; rs2241136; rs3213737; rs10492227; rs10859995; rs7308827; rs17024981; rs17024935; rs7310419; rs12301817; rs2268519; rs2270318; rs17676826; rs10492228; rs10859997; rs17024956; rs7316786; rs11108356; rs12298414; rs721199; rs11108365; rs4762264; rs10745746; rs10777763; rs12318681; rs11108360; rs17024962; rs2068662; rs17024986; rs6538696; rs7133811; rs7966537; rs17676451; rs4762263; rs17024995; rs12427251; rs12319274; rs4762262; rs7308844; rs7137420; rs7136523; rs12307364; rs17024937; rs11108361; rs11108359; rs17677007; rs3741815; rs17733203; rs10859998; rs2241137; rs10777764; rs7308555; rs7136852; rs2070614; rs1059845; rs1059844; rs7134860; rs7970524; rs7134975; rs10859999; rs3829305; rs11835389; rs7956014; rs10777762; rs11108371; rs11108370; rs7306086; rs34457757; rs35643296; rs34268157; rs34541335; rs7304917; rs4418880; rs34738482; rs11108363; rs10708992; rs12814960; rs2287056; rs6538693; rs34148511; rs35249157; rs6538694; rs4451792; rs4595631; rs4762659; rs34975193; rs34466661; rs35532808; rs2270317; rs12810515; rs12809145; rs2287055; rs11108358; rs12298212; rs35351448; rs1108405; rs6538695; rs4995764; rs7137747; rs11108362; rs3214368; rs35963926; rs11108357; rs11108367; rs35777937; rs3764037; rs12297099; rs34515139; rs11454735; rs2287057; rs36054506; rs4995766; rs35144639; rs35152917; rs12810520; rs35559744; rs4995765; rs12822785; rs12809482; rs12297102; rs12309712; rs12298680; rs4325387; rs10537373; rs7975900; rs34539324; rs12310543; rs12824794; rs3812807; rs12231580; rs12826052; rs12826051; rs34149011; rs12231566; rs12826042; rs12826043; rs12231565; rs7976204; rs12826048; rs12826049; rs34600440; rs1025606; rs1025607; rs1025608; rs10507068; rs10507069; rs1050970; rs10777757; rs11108355; rs11108372; rs11108373; rs11613777; rs11614411; rs11826; rs11837995; rs12302993; rs12322336; rs12581429; rs17024904; rs17024908; rs17025016; rs17025023; rs17025026; rs17025028; rs17677343; rs1803916; rs2540499; rs2540500; rs4762258; rs4762657; rs4762658; rs5020450; rs7486464; rs7963056; rs7975895; rs7976105; rs7976535

# Metabolic_Enzyme_31_General_References:
7916645; 8530107

# Metabolic_Enzyme_31_References:
Not Available

# Metabolic_Enzyme_32_ID:
5631

# Metabolic_Enzyme_32_Name:
Retina-specific copper amine oxidase precursor

# Metabolic_Enzyme_32_Synonyms:
RAO; Amine oxidase [copper-containing]

# Metabolic_Enzyme_32_Gene_Name:
AOC2

# Metabolic_Enzyme_32_Protein_Sequence:
>Retinaspecific copper amine oxidase precursor
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLS
REELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREA
LAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLK
EVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLE
LLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRN
SPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQ
ECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLP
GAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALE
GRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDV
VFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYR
IQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFI
NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVY
FEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

# Metabolic_Enzyme_32_Number_of_Residues:
756

# Metabolic_Enzyme_32_Molecular_Weight:
83674

# Metabolic_Enzyme_32_Theoretical_pI:
7.03

# Metabolic_Enzyme_32_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_32_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_32_Specific_Function:
May be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine

# Metabolic_Enzyme_32_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00340  Histidine metabolism;
 map00350  Tyrosine metabolism;
 map00360  Phenylalanine metabolism;
 map00380  Tryptophan metabolism;
 map00410  beta-Alanine metabolism;
 map00960  Alkaloid biosynthesis II

# Metabolic_Enzyme_32_Reaction:
RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2

# Metabolic_Enzyme_32_Pfam_Domain_Function:
PF01179:Cu_amine_oxid;
PF02727:Cu_amine_oxidN2;
PF02728:Cu_amine_oxidN3

# Metabolic_Enzyme_32_Signals:
1-32

# Metabolic_Enzyme_32_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_32_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_32_EC_Link:
EC 1.4.3.6

# Metabolic_Enzyme_32_GenBank_ID_Protein:
1906806

# Metabolic_Enzyme_32_SwissProt_ID:
AOC2_HUMAN (O75106)

# Metabolic_Enzyme_32_swissprot_Name:
Not Available

# Metabolic_Enzyme_32_Genecard_id:
AOC2

# Metabolic_Enzyme_32_Geneatlas_id:
AOC2

# Metabolic_Enzyme_32_hgnc_id:
HGNC:549

# Metabolic_Enzyme_32_PDB_ID:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_32_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_32_Subcellular_Location:
Membrane

# Metabolic_Enzyme_32_Gene_Sequence:
>2190 bp
ATGCATCTCAAGATAGTCCTGGCGTTCCTGGCACTGTCCCTCATTACCATCTTTGCCCTG
GCCTATGTTTTGCTGACCAGCCCAGGTGGTTCCAGCCAGCCTCCCCACTGCCCCTCTGTA
TCCCATAGGGCCCAGCCCTGGCCACACCCTGGCCAGAGCCAGCTGTTTGCAGACCTGAGC
CGAGAGGAGTTGACAGCTGTGATGCGCTTTCTGACCCAGCGGCTGGGGCCAGGGCTGGTG
GACGCAGCCCAGGCTCAGCCCTCGGACAACTGCATCTTCTCAGTGGAGCTGCAGCTGCCC
CCCAAGGCTGCAGCCCTGGCCCACCTGGACAGGGGGAGCCCCCCACCTGCCCGGGAGGCA
CTGGCCATCGTCCTCTTTGGTGGACAACCCCAACCCAATGTGAGTGAGCTGGTGGTGGGG
CCGCTGCCTCACCCCTCGTACATGCGGGATGTGACTGTGGAGCGTCACGGCGGGCCCCTG
CCCTATCACCGTCGCCCGGTGCTGAGAGCTGAGTTTACACAGATGTGGAGGCATCTGAAA
GATGTGGAGCTACCCAAGGCACCCATCTTCCTGTCGTCCACCTTCAACTACAATGGCTCT
ACCCTGGCAGCTGTGCATGCCACCCCTCGGGGCTTGCGCTCAAGGGAACGAACTACCTGG
ATTGGCCTCTACCATAACATCTCAGGGGTTGGTCTTTTCCTTCACCCCGTGGGGCTGGAG
CTACTACTGGACCACAGGGCCCTGGACCCTGCCCACTGGACTGTCCAGCAGGTCTTCTAC
CTTGGGCACTACTATGCAGACTTGGGCCAGTTGGAACGGGAGTTTAAGTCTGGCCGGTTG
GAAGTGGTTAGAGTCCCTCTACCTCCACCAAATGGAGCTTCATCCCTGAGGTCTCGGAAC
TCTCCAGGTCCTCTTCCCCCTCTTCAGTTCTCGCCCCAGGGTTCCCAGTACAGTGTGCAA
GGAAACCTGGTGGTATCCTCCCTCTGGTCATTTACCTTTGGCCATGGGGTGTTCAGCGGC
CTGAGGATTTTTGATGTTCGGTTCCAGGGTGAGCGAATAGCCTATGAAGTCAGTGTCCAG
GAGTGTGTATCTATCTATGGTGCCGATTCACCCAAGACGATGCTGACTCGCTATTTGGAT
AGCAGCTTTGGACTCGGCCGTAACAGCCGAGGCTTGGTGCGGGGAGTGGACTGCCCCTAT
CAAGCCACGATGGTGGACATCCATATATTAGTGGGCAAAGGGGCAGTCCAGCTGCTTCCA
GGGGCTGTGTGTGTATTTGAGGAAGCCCAGGGACTGCCCCTTCGAAGGCACCACAATTAC
CTTCAAAATCATTTCTATGGTGGTTTGGCCAGCTCAGCCCTTGTGGTCAGGTCTGTGTCA
TCTGTGGGCAACTATGACTACATTTGGGACTTTGTGTTGTACCCAAATGGGGCACTTGAA
GGGCGGGTCCATGCCACGGGTTATATCAACACAGCTTTCCTGAAAGGGGGAGAGGAGGGC
CTCCTCTTTGGGAACCGTGTGGGGGAAAGAGTGCTGGGAACGGTGCACACACATGCCTTC
CACTTCAAGCTGGACCTGGATGTGGCAGGGCTGAAAAACTGGGTGGTAGCTGAAGACGTG
GTGTTTAAACCTGTGGCTGCCCCCTGGAACCCGGAGCACTGGCTACAGCGCCCACAGCTG
ACTCGGCAGGTCCTGGGAAAGGAGGACCTGACAGCTTTTTCCTTGGGAAGCCCCCTACCC
CGCTACCTCTACCTGGCTAGCAACCAGACTAATGCGTGGGGTCACCAGCGCGGATACCAG
CTTGTGGTGACCCAGAGAAAGGAGGAGGAGTCACAGAGCAGTAGCATCTATCACCAGAAT
GACATCTGGACACCCACAGTTACCTTTGCTGACTTCATCAACAATGAAACCCTCTTAGGA
GAGGATCTGGTGGCTTGGGTCACAGCCAGCTTCCTGCACATTCCCCATGCCGAGGACATC
CCAAACACAGTGACTCTGGGGAACAGAGTTGGCTTCTTGCTCCGACCCTATAACTTCTTT
GATGAGGACCCCTCCATCTTCTCCCCTGGCAGTGTGTACTTTGAGAAGGGCCAGGATGCT
GGGCTCTGCAGCATCAATCCTGTGGCCTGCCTCCCCGACCTGGCAGCCTGTGTCCCGGAC
TTACCCCCTTTCTCTTACCACGGCTTCTAG

# Metabolic_Enzyme_32_GenBank_ID_Gene:
D88213

# Metabolic_Enzyme_32_Chromosome_Location:
Not Available

# Metabolic_Enzyme_32_Locus:
Not Available

# Metabolic_Enzyme_32_SNPs:
Not Available

# Metabolic_Enzyme_32_General_References:
9119395; 9722954

# Metabolic_Enzyme_32_References:
Not Available

# Metabolic_Enzyme_33_ID:
5871

# Metabolic_Enzyme_33_Name:
AMP deaminase 2

# Metabolic_Enzyme_33_Synonyms:
AMP deaminase isoform L

# Metabolic_Enzyme_33_Gene_Name:
AMPD2

# Metabolic_Enzyme_33_Protein_Sequence:
>AMP deaminase 2
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAAVVPAMASYPS
GSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARSLPGPAPCLKHFPLDLRTSMD
GKCKEIAEELFTRSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLR
AKQDFLKTDSDSDLQLYKEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDA
AKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVN
VLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIH
ASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHAD
RNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELR
LSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYL
YYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQ
YLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY
SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRV
GYRYETLCQELALITQAVQSEMLETIPEEAGITMSPGPQ

# Metabolic_Enzyme_33_Number_of_Residues:
879

# Metabolic_Enzyme_33_Molecular_Weight:
100689

# Metabolic_Enzyme_33_Theoretical_pI:
6.93

# Metabolic_Enzyme_33_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_33_General_Function:
Not Available

# Metabolic_Enzyme_33_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_33_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_33_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_33_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_33_Signals:
None

# Metabolic_Enzyme_33_Transmembrane_Regions:
None

# Metabolic_Enzyme_33_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_33_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_33_GenBank_ID_Protein:
644509

# Metabolic_Enzyme_33_SwissProt_ID:
AMPD2_HUMAN (Q01433)

# Metabolic_Enzyme_33_swissprot_Name:
Not Available

# Metabolic_Enzyme_33_Genecard_id:
AMPD2

# Metabolic_Enzyme_33_Geneatlas_id:
AMPD2

# Metabolic_Enzyme_33_hgnc_id:
HGNC:469

# Metabolic_Enzyme_33_PDB_ID:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_33_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_33_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_33_Gene_Sequence:
>2263 bp
CGCCGAGGAGCTGTTCACCCGCTCACTGGCTGAGAGCGAGCTCCGTAGTGCCCCGTATGA
GTTCCCCGAGGAGAGCCCCATTGAACAGCTGGAGGAGCGGCGGCAGCGGCTGGAGCGGCA
GATCAGCCAGGATGTCAAGCTGGAGCCAGACATCCTGCTTCGGGCCAAGCAAGATTTCCT
GAAGACGGACAGTGACTCGGACCTACAGCTCTACAAGGAACAGGGTGAGGGGCAGGGTGA
CCGGAGCCTGCGGGAGCGTGATGTGCTGGAACGGGAGTTTCAGCGGGTCACCATCTCTGG
GGAGGAGAAGTGTGGGGTGCCGTTCACAGACCTGCTGGATGCAGCCAAGAGTGTGGTGCG
GGCGCTCTTCATCCGGGAGAAGTACATGGCCCTGTCCCTGCAGAGCTTCTGCCCCACCAC
CCGCCGCTACCTGCAGCAGCTGGCTGAAAAGCCTCTGGAGACCCGGACCTATGAACAGGG
CCCCGACACCCCTGTGTCTGCTGATGCCCCGGTGCACCCCCCTGCGCTGGAGCAGCACCC
GTATGAGCACTGTGAGCCAAGCACCATGCCTGGGGACCTGGGCTTGGGTCTGCGCATGGT
GCGGGGTGTGGTGCACGTCTACACCCGCAGGGAACCCGACGAGCATTGCTCAGAGGTGGA
GCTGCCATACCCTGACCTGCAGGAATTTGTGGCTGACGTCAATGTGCTGATGGCCCTGAT
TATCAATGGCCCCATAAAGTCATTCTGCTACCGCCGGCTGCAGTACCTGAGCTCCAAGTT
CCAGATGCATGTGCTACTCAATGAGATGAAGGAGCTGGCCGCCCAGAAGAAAGTGCCACA
CCGAGATTTCTACAACATCCGCAAGGTGGACACCCACATCCATGCCTCGTCCTGCATGAA
CCAGAAGCATCTGCTGCGCTTCATCAAGCGGGCAATGAAGCGGCACCTGGAGGAGATCGT
GCACGTGGAGCAGGGCCGTGAACAGACGCTGCGGGAGGTCTTTGAGAGCATGAATCTCAC
GGCCTACGACCTGAGTGTGGACACGCTGGATGTGCATGCGGACAGGAACACTTTCCATCG
CTTTGACAAGTTTAATGCCAAATACAACCCTATTGGGGAGTCCGTCCTCCGAGAGATCTT
CATCAAGACGGACAACAGGGTATCTGGGAAGTACTTTGCTCACATCATCAAGGAGGTGAT
GTCAGACCTGGAGGAGAGCAAATACCAGAATGCAGAGCTGCGGCTCTCCATTTACGGGCG
CTCGAGGGATGAGTGGGACAAGCTGGCGCGCTGGGCCGTCATGCACCGCGTGCACTCCCC
CAACGTGCGCTGGCTGGTGCAGGTGCCCCGCCTCTTTGATGTGTACCGTACCAAGGGCCA
GCTGGCCAACTTCCAGGAGATGCTGGAGAACATCTTCCTGCCACTGTTCGAGGCCACTGT
GCACCCTGCCAGCCACCCGGAACTGCATCTCTTCTTAGAGCACGTGGATGGTTTTGACAG
CGTGGATGATGAGTCCAAGCCTGAAAACCATGTCTTCAACCTGGAGAGCCCCCTGCCTGA
GGCGTGGGTGGAGGAGGACAACCCACCCTATGCCTACTACCTGTACTACACCTTTGCCAA
CATGGCCATGTTGAACCACCTGCGCAGGCAGAGGGGCTTCCACACGTTTGTGCTGAGGCC
ACACTGTGGGGAGGCTGGGCCCATCCACCACCTGGTGTCAGCCTTCATGCTGGCTGAGAA
CATTTCCCACGGGCTCCTTCTGCGCAAGGCCCCCGTCCTGCAGTACCTGTACTACCTGGC
CCAGATCGGCATCGCCATGTCTCCGCTCAGCAACAACAGCCTCTTCCTCAGCTATCACCG
GAATCCGCTACCGGAGTACCTGTCCCGCGGCCTCATGGTCTCCCTGTCCACTGATGATCC
CTTGCAGTTCCACTTCACCAAGGAGCCGCTGATGGAGGAGTACAGCATCGCCACCCAGGT
GTGGAAGCTCAGCTCCTGCGATATGTGTGAGCTGGCCCGCAACAGCGTGCTCATGAGCGG
CTTCTCGCACAAGGTAAAGAGCCACTGGCTGGGACCCAACTATACCAAGGAAGGCCCTGA
GGGGAATGACATCCGCCGGACCAATGTGCCAGACATCCGCGTGGGCTACCGCTACGAGAC
CCTGTGCCAGGAGCTGGCGCTCATCACGCAGGCAGTCCAGAGTGAGATGCTGGAGACCAT
TCCAGAGGAGGCGGGTATCACCATGAGCCCAGGGCCTCAATGA

# Metabolic_Enzyme_33_GenBank_ID_Gene:
M91029

# Metabolic_Enzyme_33_Chromosome_Location:
Not Available

# Metabolic_Enzyme_33_Locus:
Not Available

# Metabolic_Enzyme_33_SNPs:
Not Available

# Metabolic_Enzyme_33_General_References:
1429593; 8526848; 8764830

# Metabolic_Enzyme_33_References:
Not Available

# Metabolic_Enzyme_34_ID:
5815

# Metabolic_Enzyme_34_Name:
Beta-ureidopropionase

# Metabolic_Enzyme_34_Synonyms:
Beta-alanine synthase; N- carbamoyl-beta-alanine amidohydrolase; BUP-1

# Metabolic_Enzyme_34_Gene_Name:
UPB1

# Metabolic_Enzyme_34_Protein_Sequence:
>Betaureidopropionase
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPR
IVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQE
AWTMPFAFCTREKLPWTEFAE
SAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLW
NTAVVISNSGAVLGKTRKNHIPRVGDFNESTY
YMEGNLGHPVFQTQFGRIAVNICYGRH
HPLNWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANH
CFTCAINRVGTEHFPN
EFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQV
NDVWN
FKMTGRYEMYARELAEAVKSNYSPTIVKE

# Metabolic_Enzyme_34_Number_of_Residues:
384

# Metabolic_Enzyme_34_Molecular_Weight:
43166

# Metabolic_Enzyme_34_Theoretical_pI:
6.51

# Metabolic_Enzyme_34_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  nitrogen compound metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_34_General_Function:
Not Available

# Metabolic_Enzyme_34_Specific_Function:
Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide

# Metabolic_Enzyme_34_Pathway:
map00240  Pyrimidine metabolism;
 map00410  beta-Alanine metabolism;
 map00770  Pantothenate and CoA biosynthesis

# Metabolic_Enzyme_34_Reaction:
N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3

# Metabolic_Enzyme_34_Pfam_Domain_Function:
PF00795:CN_hydrolase

# Metabolic_Enzyme_34_Signals:
None

# Metabolic_Enzyme_34_Transmembrane_Regions:
None

# Metabolic_Enzyme_34_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_34_EC_Link:
EC 3.5.1.6

# Metabolic_Enzyme_34_GenBank_ID_Protein:
6288771

# Metabolic_Enzyme_34_SwissProt_ID:
BUP1_HUMAN (Q9UBR1)

# Metabolic_Enzyme_34_swissprot_Name:
Not Available

# Metabolic_Enzyme_34_Genecard_id:
UPB1

# Metabolic_Enzyme_34_Geneatlas_id:
UPB1

# Metabolic_Enzyme_34_hgnc_id:
HGNC:16297

# Metabolic_Enzyme_34_PDB_ID:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_34_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_34_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_34_Gene_Sequence:
>1155 bp

ATGGCGGGCGCTGAGTGGAAGTCGCTGGAGGAATGCTTGGAGAAGCACCTGCCGCTCCC
CGACTTGCAGG
AAGTGAAGCGCGTTCTCTATGGCAAGGAACTCAGGAAGCTTGATCTGC
CCAGGGAAGCTTTCGAAGCTGC
CTCCAGAGAAGACTTTGAACTGCAGGGATATGCCTTT
GAAGCAGCGGAGGAGCAGCTGAGACGACCCCGC
ATTGTGCACGTGGGGCTGGTTCAGAA
CAGAATCCCCCTCCCCGCAAATGCCCCTGTGGCAGAACAGGTCT
CTGCCCTTCATAGAC
GCATAAAGGCTATCGTAGAGGTGGCTGCAATGTGTGGAGTCAACATCATCTGTTT
CCAG
GAAGCATGGACTATGCCCTTTGCCTTCTGTACGAGAGAGAAGCTTCCTTGGACAGAATTT
GCTGAG
TCAGCAGAGGATGGGCCCACCACCAGATTCTGTCAGAAGCTGGCGAAGAACCA
TGACATGGTGGTGGTGT
CTCCCATCCTGGAACGAGACAGCGAGCATGGGGATGTTTTGT
GGAATACAGCCGTGGTGATCTCCAATTC
CGGAGCAGTCCTGGGAAAGACCAGGAAAAAC
CACATCCCCAGAGTGGGTGATTTCAACGAGTCAACTTAC
TACATGGAGGGAAACCTGGG
CCACCCCGTGTTCCAGACGCAGTTCGGAAGGATCGCGGTGAACATTTGCT
ACGGGCGGC
ACCACCCCCTCAACTGGCTTATGTACAGCATCAACGGGGCTGAGATCATCTTCAACCCCT
C
GGCCACGATAGGAGCACTCAGCGAGTCCCTGTGGCCCATCGAGGCCAGAAACGCAGCC
ATTGCCAATCAC
TGCTTCACCTGCGCCATCAATCGAGTGGGCACCGAGCACTTCCCGAA
CGAGTTTACCTCGGGAGATGGAA
AGAAAGCTCACCAGGACTTTGGCTACTTTTATGGCT
CGAGCTATGTGGCAGCCCCTGACAGCAGCCGGAC
TCCTGGGCTGTCCCGTAGCCGGGAT
GGACTGCTAGTTGCTAAGCTCGACCTAAACCTCTGCCAGCAGGTG
AATGATGTCTGGAA
CTTCAAGATGACGGGCAGGTATGAGATGTACGCACGGGAGCTCGCCGAAGCTGTCA
AGT
CCAACTACAGCCCCACCATCGTGAAAGAGTAG

# Metabolic_Enzyme_34_GenBank_ID_Gene:
AF163312

# Metabolic_Enzyme_34_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_34_Locus:
22q11.2

# Metabolic_Enzyme_34_SNPs:
rs34110964; rs2232867; rs1314; rs2070474; rs2232866; rs140330; rs6004171; rs1892721; rs2232868; rs738814; rs1015011; rs140324; rs5760464; rs140338; rs6004175; rs5996713; rs762279; rs8142051; rs140335; rs3788372; rs12159862; rs3788369; rs140337; rs131455; rs2298384; rs5760455; rs131456; rs1015050; rs12628029; rs6004167; rs5760467; rs175766; rs5996712; rs140334; rs4414772; rs35270298; rs2298385; rs3788370; rs5751894; rs9612646; rs3788371; rs8141985; rs5751893; rs140331; rs8139394; rs11912222; rs5760466; rs7290860; rs5760459; rs11704820; rs16978612; rs140332; rs2232865; rs6004174; rs5751892; rs7289159; rs2070473; rs34035085; rs9620392; rs2232870; rs35916595; rs2070475; rs34595756; rs33939150; rs6004176; rs175767; rs9608293; rs13055831; rs5760465; rs5760457; rs34272823; rs34212925; rs11704528; rs140339; rs5760461; rs5751891; rs9620394; rs34817009; rs35770800; rs5760458; rs5844593; rs9624489; rs131454; rs10428056; rs10427702; rs6004172; rs5760460; rs7290073; rs140326; rs12170801; rs41446544; rs11306738; rs8139687; rs35821245; rs140329; rs11912437; rs11704936; rs28588566; rs9612641; rs12159402; rs9624487; rs5751890; rs5996709; rs28793636; rs35606558; rs34346301; rs5760463; rs12168497; rs35350082; rs6004168; rs140327; rs5996711; rs34804666; rs12166299; rs140325; rs13056366; rs12170842; rs140328; rs131452; rs6004173; rs8137394; rs9624485; rs9624488; rs34688005; rs9624486; rs9612637; rs12159199; rs9608291; rs140333; rs10427760; rs5996710; rs12169955; rs2232864; rs6004169; rs3765615; rs11350644; rs140336; rs3032747; rs34577100; rs13056367; rs9624484; rs6004170; rs2232869; rs9612640; rs28461476; rs7289603; rs5760462; rs131453; rs4049935; rs34276962; rs5760456; rs11913979; rs9612643; rs34916208; rs34067128; rs41302573; rs2232863; rs2232862; rs2232858; rs2232860; rs5751889; rs7289016; rs2232861; rs2232859; rs2232857; rs11090327; rs131460; rs140342; rs1543757; rs17004940; rs4346492; rs4558681; rs4820592; rs4822501; rs4822502; rs5760449; rs5760450; rs5760451; rs5760452; rs5760469; rs5996707; rs5996715; rs9612648

# Metabolic_Enzyme_34_General_References:
10542323; 11508704

# Metabolic_Enzyme_34_References:
Not Available

# Metabolic_Enzyme_35_ID:
5957

# Metabolic_Enzyme_35_Name:
Protein-arginine deiminase type-2

# Metabolic_Enzyme_35_Synonyms:
Protein-arginine deiminase type II; Peptidylarginine deiminase II; PAD-H19

# Metabolic_Enzyme_35_Gene_Name:
PADI2

# Metabolic_Enzyme_35_Protein_Sequence:
>Proteinarginine deiminase type2
MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP

# Metabolic_Enzyme_35_Number_of_Residues:
665

# Metabolic_Enzyme_35_Molecular_Weight:
75565

# Metabolic_Enzyme_35_Theoretical_pI:
5.28

# Metabolic_Enzyme_35_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_35_General_Function:
Not Available

# Metabolic_Enzyme_35_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_35_Pathway:
Not Available

# Metabolic_Enzyme_35_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_35_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_35_Signals:
None

# Metabolic_Enzyme_35_Transmembrane_Regions:
None

# Metabolic_Enzyme_35_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_35_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_35_GenBank_ID_Protein:
5572747

# Metabolic_Enzyme_35_SwissProt_ID:
PADI2_HUMAN (Q9Y2J8)

# Metabolic_Enzyme_35_swissprot_Name:
Not Available

# Metabolic_Enzyme_35_Genecard_id:
PADI2

# Metabolic_Enzyme_35_Geneatlas_id:
PADI2

# Metabolic_Enzyme_35_hgnc_id:
HGNC:18341

# Metabolic_Enzyme_35_PDB_ID:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_35_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_35_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_35_Gene_Sequence:
>1998 bp
ATGCTGCGCGAGCGGACCGTGCGGCTGCAGTACGGGAGCCGCGTGGAGGCGGTGTACGTG
CTGGGCACCTACCTCTGGACCGATGTCTACAGCGCGGCCCCAGCCGGGGCCCAAACCTTC
AGCCTGAAGCACTCGGAACACGTGTGGGTGGAGGTGGTGCGTGATGGGGAGGCTGAGGAG
GTGGCCACCAATGGCAAGCAGCGCTGGCTTCTCTCGCCCAGCACCACCCTGCGGGTCACC
ATGAGCCAGGCGAGCACCGAGGCCAGCAGTGACAAGGTCACCGTCAACTACTATGACGAG
GAAGGGAGCATTCCCATCGACCAGGCGGGGCTCTTCCTCACAGCCATTGAGATCTCCCTG
GATGTGGACGCAGACCGGGATGGTGTGGTGGAGAAGAACAACCCAAAGAAGGCATCCTGG
ACCTGGGGCCCCGAGGGCCAGGGGGCCATCCTGCTGGTGAACTGTGACCGAGAGACACCC
TGGTTGCCCAAGGAGGACTGCCGTGATGAGAAGGTCTACAGCAAGGAAGATCTCAAGGAC
ATGTCCCAGATGATCCTGCGGACCAAAGGCCCCGACCGCCTCCCCGCCGGATACGAGATA
GTTCTGTACATTTCCATGTCAGACTCAGACAAAGTGGGCGTGTTCTACGTGGAGAACCCG
TTCTTCGGCCAACGCTATATCCACATCCTGGGCCGGCGGAAGCTCTACCATGTGGTCAAG
TACACGGGTGGCTCCGCGGAGCTGCTGTTCTTCGTGGAAGGCCTCTGTTTCCCCGACGAG
GGCTTCTCAGGCCTGGTCTCCATCCATGTCAGCCTGCTGGAGTACATGGCCCAGGACATT
CCCCTGACTCCCATCTTCACGGACACCGTGATATTCCGGATTGCTCCGTGGATCATGACC
CCCAACATCCTGCCTCCCGTGTCGGTGTTTGTGTGCTGCATGAAGGATAATTACCTGTTC
CTGAAAGAGGTGAAGAACCTTGTGGAGAAAACCAACTGTGAGCTGAAGGTCTGCTTCCAG
TACCTAAACCGAGGCGATCGCTGGATCCAGGATGAAATTGAGTTTGGCTACATCGAGGCC
CCCCATAAAGGCTTCCCCGTGGTGCTGGACTCTCCCCGAGATGGAAACCTAAAGGACTTC
CCTGTGAAGGAGCTCCTGGGCCCAGATTTTGGCTACGTGACCCGGGAGCCCCTCTTTGAG
TCTGTCACCAGCCTTGACTCATTTGGAAACCTGGAGGTCAGTCCCCCAGTGACCGTGAAC
GGCAAGACATACCCGCTTGGCCGCATCCTCATCGGGAGCAGCTTTCCTCTGTCTGGTGGT
CGGAGGATGACCAAGGTGGTGCGTGACTTCCTGAAGGCCCAGCAGGTGCAGGCACCCGTG
GAGCTCTACTCAGACTGGCTGACTGTGGGCCACGTGGATGAGTTCATGTCCTTTGTCCCC
ATCCCCGGCACAAAGAAATTCCTGCTACTCATGGCCAGCACCTCGGCCTGCTACAAGCTC
TTCCGAGAGAAGCAGAAGGACGGCCATGGAGAGGCCATCATGTTCAAAGGCTTGGGTGGG
ATGAGCAGCAAGCGAATCACCATCAACAAGATTCTGTCCAACGAGAGCCTTGTGCAGGAG
AACCTGTACTTCCAGCGCTGCCTGGACTGGAACCGTGACATCCTCAAGAAGGAGCTGGGA
CTGACAGAGCAGGACATCATTGACCTGCCCGCTCTGTTCAAGATGGACGAGGACCACCGT
GCCAGAGCCTTCTTCCCAAACATGGTGAACATGATCGTGCTGGACAAGGACCTGGGCATC
CCCAAGCCATTCGGGCCACAGGTTGAGGAGGAATGCTGCCTGGAGATGCACGTGCGTGGC
CTCCTGGAGCCCCTGGGCCTCGAATGCACCTTCATCGACGACATTTCTGCCTACCACAAA
TTTCTGGGGGAAGTCCACTGTGGCACCAACGTCCGCAGGAAGCCCTTCACCTTCAAGTGG
TTGCACATGGTGCCCTGA

# Metabolic_Enzyme_35_GenBank_ID_Gene:
AB030176

# Metabolic_Enzyme_35_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_35_Locus:
1p36.13

# Metabolic_Enzyme_35_SNPs:
rs2076595; rs2076615; rs11581590; rs3818032; rs2057096; rs11203297; rs35184728; rs2235926; rs2647176; rs2076598; rs2076599; rs2235917; rs2076611; rs2311483; rs2057092; rs742798; rs2076617; rs2295052; rs2076614; rs2235923; rs2235918; rs742797; rs2746515; rs2746510; rs2235910; rs2076607; rs1005753; rs2235925; rs2235913; rs1980509; rs2244949; rs2014725; rs2076616; rs2647174; rs2235920; rs1883912; rs4920337; rs2647190; rs2076597; rs2647189; rs2057095; rs1569755; rs3818040; rs2295050; rs2295053; rs910232; rs11203298; rs2235924; rs4448563; rs2235919; rs1022579; rs3818039; rs2235909; rs2057093; rs878270; rs910228; rs2143810; rs2076596; rs2295051; rs3818021; rs3818034; rs2014719; rs2647203; rs2647187; rs878269; rs2076609; rs2746529; rs875219; rs910229; rs2016693; rs6663485; rs3818037; rs2235914; rs730387; rs737428; rs2647192; rs2273111; rs875218; rs2076613; rs1980510; rs2076608; rs2746517; rs2243403; rs2076610; rs11587313; rs3818038; rs3818033; rs1883913; rs2647194; rs910233; rs2014718; rs3818042; rs910224; rs6701620; rs2076612; rs2235911; rs10788656; rs910230; rs11203295; rs9435751; rs733785; rs932454; rs9435753; rs1810519; rs11587487; rs9435752; rs2235922; rs3818031; rs910234; rs761426; rs2746495; rs2295046; rs3818036; rs16862492; rs2647197; rs3853182; rs12562528; rs10887996; rs910231; rs3818035; rs3818041; rs1980508; rs932453; rs2311481; rs2647184; rs2746508; rs2746500; rs2746509; rs2076594; rs3818029; rs2295045; rs11203299; rs7528156; rs2647198; rs7547459; rs761427; rs11203300; rs2244416; rs12759261; rs2746524; rs12138566; rs12134165; rs4920499; rs2746518; rs2295048; rs2647183; rs2746531; rs11203293; rs2057091; rs2018865; rs12750541; rs7514768; rs11588995; rs2057094; rs3818028; rs742796; rs2746493; rs2235915; rs2746506; rs2647199; rs11203301; rs2746523; rs2295054; rs2647172; rs2235912; rs2746496; rs2746504; rs2057090; rs6701159; rs11585299; rs7527697; rs11587943; rs12138461; rs12134154; rs2746501; rs12760512; rs761428; rs3818048; rs7530720; rs2281375; rs2647204; rs2295047; rs11805924; rs2746514; rs2647196; rs2746516; rs6675839; rs2746507; rs2143809; rs16862487; rs7523483; rs2647185; rs12411274; rs11576552; rs2647200; rs7523863; rs12134161; rs3830849; rs2235916; rs3818024; rs2281371; rs10887995; rs2235927; rs10157387; rs12133334; rs10157828; rs2746533; rs7516087; rs7515926; rs34847454; rs28537669; rs34737582; rs41306576; rs12747805; rs35341457; rs35674150; rs10649306; rs35108553; rs35030632; rs2746526; rs11203296; rs12748792; rs3036925; rs2746503; rs6684135; rs34902742; rs35540201; rs2647195; rs2746525; rs3215573; rs35413530; rs35821832; rs34454132; rs11378857; rs5772746; rs2746519; rs2746512; rs9435678; rs12085708; rs5772745; rs35004594; rs2235921; rs11811281; rs12734680; rs35155795; rs9730696; rs35828042; rs35113591; rs34076449; rs4989050; rs35342519; rs7534962; rs2746494; rs3036950; rs2647173; rs11368051; rs2746497; rs34270969; rs7511776; rs35868646; rs35960604; rs12058264; rs12754937; rs7528576; rs34687070; rs2746511; rs9435679; rs2295049; rs34532867; rs2647202; rs3036927; rs12138095; rs2647186; rs12130579; rs2647191; rs10562890; rs28396974; rs34818115; rs11380769; rs11382317; rs35136759; rs2647205; rs34698547; rs36117244; rs11415862; rs28580781; rs12094327; rs5772744; rs12741570; rs3036949; rs35779977; rs35961895; rs12090019; rs12024925; rs2647171; rs9725028; rs2281373; rs3036928; rs2746527; rs2295055; rs2092615; rs2647193; rs35040835; rs2647175; rs12760872; rs35479817; rs12062472; rs34849915; rs12081625; rs35030672; rs2647201; rs742795; rs35231839; rs2746522; rs6698353; rs35627406; rs12735968; rs2647206; rs12755767; rs35868287; rs2746502; rs35210292; rs2746505; rs9725030; rs35036779; rs2179794; rs34438749; rs2647170; rs28736624; rs11270306; rs7534768; rs2746499; rs11586592; rs12732522; rs2019192; rs33945320; rs2281372; rs34391605; rs6662829; rs34778293; rs5772747; rs41306574; rs35705744; rs3036954; rs36091753; rs34731873; rs3036923; rs35058101; rs2746492; rs7516094; rs34129774; rs35023393; rs34043625; rs1007282; rs11203290; rs11203292; rs12078020; rs12126285; rs12134582; rs12404121; rs12728190; rs1569753; rs2143811; rs2647177; rs2647180; rs2746534; rs2746535; rs2746542; rs2746543; rs2746544; rs34410889; rs4920442

# Metabolic_Enzyme_35_General_References:
10231032

# Metabolic_Enzyme_35_References:
Not Available

# Metabolic_Enzyme_36_ID:
5958

# Metabolic_Enzyme_36_Name:
GMP reductase 1

# Metabolic_Enzyme_36_Synonyms:
Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1

# Metabolic_Enzyme_36_Gene_Name:
GMPR

# Metabolic_Enzyme_36_Protein_Sequence:
>GMP reductase 1
MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGT
FEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAV
PQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGV
GPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVM
LGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGD
VENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS

# Metabolic_Enzyme_36_Number_of_Residues:
345

# Metabolic_Enzyme_36_Molecular_Weight:
37419

# Metabolic_Enzyme_36_Theoretical_pI:
7.08

# Metabolic_Enzyme_36_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on NADH or NADPH
Function:  oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
Function:  GMP reductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_36_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_36_Specific_Function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

# Metabolic_Enzyme_36_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_36_Reaction:
inosine 5'-phosphate + ammonia + NADP+ = guanosine 5'-phosphate + NADPH + H+

# Metabolic_Enzyme_36_Pfam_Domain_Function:
PF00478:IMPDH

# Metabolic_Enzyme_36_Signals:
None

# Metabolic_Enzyme_36_Transmembrane_Regions:
None

# Metabolic_Enzyme_36_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_36_EC_Link:
EC 1.7.1.7

# Metabolic_Enzyme_36_GenBank_ID_Protein:
529232

# Metabolic_Enzyme_36_SwissProt_ID:
GMPR1_HUMAN (P36959)

# Metabolic_Enzyme_36_swissprot_Name:
Not Available

# Metabolic_Enzyme_36_Genecard_id:
GMPR

# Metabolic_Enzyme_36_Geneatlas_id:
GMPR

# Metabolic_Enzyme_36_hgnc_id:
HGNC:4376

# Metabolic_Enzyme_36_PDB_ID:
2BLE

# Metabolic_Enzyme_36_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_36_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_36_Subcellular_Location:
Not Available

# Metabolic_Enzyme_36_Gene_Sequence:
>87 bp
ATGCCCCGCATAGATGCGGACCTCAAGCTCGACTTCAAGGATGTCCTGCTCCGACCTAAG
CGGAGCAGCCTCAAGAGCCGAGCCGAG

# Metabolic_Enzyme_36_GenBank_ID_Gene:
L35304

# Metabolic_Enzyme_36_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_36_Locus:
6p23

# Metabolic_Enzyme_36_SNPs:
Not Available

# Metabolic_Enzyme_36_General_References:
2758468; 1661705; 14574404; 1757097

# Metabolic_Enzyme_36_References:
Not Available

# Metabolic_Enzyme_37_ID:
5959

# Metabolic_Enzyme_37_Name:
Formimidoyltransferase-cyclodeaminase

# Metabolic_Enzyme_37_Synonyms:
Formiminotransferase- cyclodeaminase; FTCD; LCHC1[Includes: Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase]

# Metabolic_Enzyme_37_Gene_Name:
FTCD

# Metabolic_Enzyme_37_Protein_Sequence:
>Formimidoyltransferasecyclodeaminase
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVE
GALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELD
VPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARK
FLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLD
FEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVA
AAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL
EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDL
QVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQ
E

# Metabolic_Enzyme_37_Number_of_Residues:
541

# Metabolic_Enzyme_37_Molecular_Weight:
58927

# Metabolic_Enzyme_37_Theoretical_pI:
5.45

# Metabolic_Enzyme_37_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  binding
Function:  vitamin binding
Function:  folic acid binding
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_37_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_37_Specific_Function:
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool

# Metabolic_Enzyme_37_Pathway:
map00670  One carbon pool by folate

# Metabolic_Enzyme_37_Reaction:
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3

# Metabolic_Enzyme_37_Pfam_Domain_Function:
PF02971:FTCD;
PF04961:FTCD_C;
PF07837:FTCD_N

# Metabolic_Enzyme_37_Signals:
None

# Metabolic_Enzyme_37_Transmembrane_Regions:
None

# Metabolic_Enzyme_37_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_37_EC_Link:
EC 2.1.2.5;EC 4.3.1.4

# Metabolic_Enzyme_37_GenBank_ID_Protein:
6537208

# Metabolic_Enzyme_37_SwissProt_ID:
FTCD_HUMAN (O95954)

# Metabolic_Enzyme_37_swissprot_Name:
Not Available

# Metabolic_Enzyme_37_Genecard_id:
FTCD

# Metabolic_Enzyme_37_Geneatlas_id:
FTCD

# Metabolic_Enzyme_37_hgnc_id:
HGNC:3974

# Metabolic_Enzyme_37_PDB_ID:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_37_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_37_Subcellular_Location:
Cytoplasm. Golgi apparatus (By similarity)

# Metabolic_Enzyme_37_Gene_Sequence:
>1626 bp
ATGTCCCAGCTGGTGGAATGCGTCCCCAACTTTTCGGAGGGGAAGAACCAGGAGGTGATC
GACGCCATCTCTGGAGCCATCACACAGACCCCGGGCTGCGTGCTGCTGGATGTGGACGCA
GGCCCTTCCACCAACCGCACCGTGTACACCTTCGTGGGGCCGCCGGAGTGCGTGGTGGAG
GGGGCCCTCAACGCTGCCCGGGTAGCTTCCCGACTTATCGACATGAGCAGGCACCAAGGA
GAGCACCCCCGCATGGGGGCCCTAGACGTCTGCCCCTTCATCCCCGTGAGGGGCGTCAGC
GTGGATGAGTGTGTGCTCTGCGCCCAGGCCTTTGGCCAGAGGCTGGCAGAGGAGCTGGAC
GTGCCAGTTTACCTGTACGGCGAGGCAGCCAGGATGGACAGTCGCCGGACCCTGCCGGCC
ATCCGGGCCGGGGAGTACGAGGCCCTCCCTAAGAAGCTCCAGCAGGCCGACTGGGCGCCC
GACTTTGGTCCCAGCTCCTTTGTCCCCAGTTGGGGGGCCACGGCCACGGGGGCGAGGAAG
TTCCTCATTGCTTTTAACATCAACCTGCTCGGCACAAAGGAGCAAGCCCACCGCATCGCG
CTCAACCTGCGGGAGCAGGGCCGCGGGAAGGACCAGCCAGGACGTCTGAAGAAAGTTCAG
GGCATTGGCTGGTACCTGGATGAGAAGAACCTGGCTCAGGTGTCCACCAATCTTCTGGAC
TTTGAGGTCACGGCACTGCACACGGTCTACGAGGAGACCTGCCGAGAAGCACAGGAGCTG
AGCCTCCCAGTGGTGGGCTCACAGCTGGTGGGCCTGGTGCCCCTGAAGGCTCTGCTGGAT
GCGGCCGCCTTCTACTGCGAGAAGGAGAACCTCTTCATCCTGGAGGAGGAGCAGCGGATC
AGGCTGGTGGTGAGCCGGCTGGGCCTGGACTCCCTGTGCCCCTTCAGCCCTAAGGAGCGG
ATCATCGAGTACCTGGTCCCTGAGCGCGGGCCTGAGCGAGGCCTGGGCAGCAAGTCCCTG
CGCGCCTTCGTGGGGGAGGTGGGTGCCCGCTCTGCGGCCCCCGGGGGCGGCTCGGTGGCG
GCGGCCGCTGCGGCCATGGGTGCGGCGCTGGGCTCCATGGTGGGCCTCATGACCTACGGG
CGGCGCCAATTCCAGTCCCTGGACACGACGATGCGGCGCCTGATCCCGCCCTTCCGCGAG
GCTTCGGCCAAGCTAACCACGCTGGTGGATGCCGACGCCGAGGCCTTCACCGCCTACCTG
GAAGCAATGAGGCTCCCCAAGAACACACCTGAGGAAAAGGACAGGCGCACGGCGGCCCTA
CAGGAGGGTCTGAGGCGGGCAGTCTCTGTGCCGCTGACGCTGGCGGAGACGGTGGCCTCG
CTGTGGCCGGCGCTGCAGGAACTGGCCCGGTGTGGGAACCTGGCCTGCCGGTCAGACCTC
CAGGTGGCGGCCAAAGCCCTGGAGATGGGCGTGTTTGGCGCATATTTCAACGTGCTCATC
AACCTGAGGGACATCACAGACGAGGCATTTAAGGACCAGATCCACCATCGTGTTTCCAGC
CTCCTGCAGGAAGCCAAGACCCAGGCTGCACTGGTGCTGGACTGCTTGGAGACCCGGCAG
GAGTGA

# Metabolic_Enzyme_37_GenBank_ID_Gene:
AF169017

# Metabolic_Enzyme_37_Chromosome_Location:
Not Available

# Metabolic_Enzyme_37_Locus:
Not Available

# Metabolic_Enzyme_37_SNPs:
rs10432965; rs2277821; rs12774; rs1047209; rs2839127; rs2839126; rs725976; rs2277820; rs7282864; rs9976772; rs2839124; rs1556341; rs1980983; rs9978174; rs7277617; rs11908960; rs2010958; rs7279849; rs9974320; rs17292975; rs2839125; rs4819208; rs17004505; rs8126678; rs11909944; rs17004504; rs8134417; rs16978935; rs4819207; rs11911736; rs9284510; rs1556340; rs16978930; rs9974226; rs3746999; rs17004506; rs11911593; rs16978932; rs4484116; rs1556339; rs11089051; rs4819209; rs914245; rs914246; rs8128111; rs8128270; rs7276274; rs28941768; rs8133955; rs1047179; rs34762382; rs35337947; rs9653792; rs9653793; rs33926654; rs2277819; rs8133080; rs4818824; rs34248722; rs34788232; rs35123061; rs7278881; rs9984474; rs28413731; rs7275864; rs9983829; rs34823397; rs4819206; rs3747000; rs35273895; rs4819205; rs9978647; rs36026689; rs12482309; rs9982796; rs2277818; rs9981364; rs7283985; rs5844255; rs13052919; rs34564917; rs12627256; rs3057182; rs8134628; rs3057172; rs4819204; rs3746998; rs34007993; rs8133524; rs4818825; rs8131374; rs28437812; rs8131105; rs10594439; rs11089050; rs11283939; rs9974540; rs8127720; rs11701284; rs35899631; rs35655527; rs11909099; rs11279411; rs35208133; rs10188; rs1042930; rs1044598; rs11908812; rs11908934; rs11909205; rs11910483; rs12329660; rs12329865; rs12482002; rs12626197; rs12626732; rs12626746; rs13050201; rs13050660; rs14378; rs16978878; rs16978880; rs16978895; rs16978897; rs16978913; rs17272947; rs17292141; rs2236492; rs2839115; rs2839116; rs2839117; rs2839118; rs2839119; rs2839120; rs2839121; rs2839122; rs2839123; rs34433115; rs35139588; rs35548026; rs35887009; rs3746997; rs3747001; rs3747002; rs3747003; rs4819210; rs559; rs6518273; rs6652; rs7280396; rs7280485; rs7281816; rs7282065; rs7717; rs8126854; rs9974913; rs9976171; rs9977394; rs9977572; rs9977766; rs9980548

# Metabolic_Enzyme_37_General_References:
10773664; 10029623; 12815595

# Metabolic_Enzyme_37_References:
Not Available

# Metabolic_Enzyme_38_ID:
5803

# Metabolic_Enzyme_38_Name:
Activation-induced cytidine deaminase

# Metabolic_Enzyme_38_Synonyms:
Cytidine aminohydrolase

# Metabolic_Enzyme_38_Gene_Name:
AICDA

# Metabolic_Enzyme_38_Protein_Sequence:
>Activationinduced cytidine deaminase
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

# Metabolic_Enzyme_38_Number_of_Residues:
198

# Metabolic_Enzyme_38_Molecular_Weight:
23954

# Metabolic_Enzyme_38_Theoretical_pI:
9.66

# Metabolic_Enzyme_38_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  zinc ion binding
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_38_General_Function:
Not Available

# Metabolic_Enzyme_38_Specific_Function:
RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

# Metabolic_Enzyme_38_Pathway:
map00240  Pyrimidine metabolism

# Metabolic_Enzyme_38_Reaction:
cytidine + H2O = uridine + ammonia

# Metabolic_Enzyme_38_Pfam_Domain_Function:
PF05240:APOBEC_C;
PF08210:APOBEC_N

# Metabolic_Enzyme_38_Signals:
None

# Metabolic_Enzyme_38_Transmembrane_Regions:
None

# Metabolic_Enzyme_38_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_38_EC_Link:
EC 3.5.4.5

# Metabolic_Enzyme_38_GenBank_ID_Protein:
9988410

# Metabolic_Enzyme_38_SwissProt_ID:
AICDA_HUMAN (Q9GZX7)

# Metabolic_Enzyme_38_swissprot_Name:
Not Available

# Metabolic_Enzyme_38_Genecard_id:
AICDA

# Metabolic_Enzyme_38_Geneatlas_id:
AICDA

# Metabolic_Enzyme_38_hgnc_id:
HGNC:13203

# Metabolic_Enzyme_38_PDB_ID:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_38_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_38_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_38_Gene_Sequence:
>597 bp
ATGGACAGCCTCTTGATGAACCGGAGGAAGTTTCTTTACCAATTCAAAAATGTCCGCTGG
GCTAAGGGTCGGCGTGAGACCTACCTGTGCTACGTAGTGAAGAGGCGTGACAGTGCTACA
TCCTTTTCACTGGACTTTGGTTATCTTCGCAATAAGAACGGCTGCCACGTGGAATTGCTC
TTCCTCCGCTACATCTCGGACTGGGACCTAGACCCTGGCCGCTGCTACCGCGTCACCTGG
TTCACCTCCTGGAGCCCCTGCTACGACTGTGCCCGACATGTGGCCGACTTTCTGCGAGGG
AACCCCAACCTCAGTCTGAGGATCTTCACCGCGCGCCTCTACTTCTGTGAGGACCGCAAG
GCTGAGCCCGAGGGGCTGCGGCGGCTGCACCGCGCCGGGGTGCAAATAGCCATCATGACC
TTCAAAGATTATTTTTACTGCTGGAATACTTTTGTAGAAAACCATGAAAGAACTTTCAAA
GCCTGGGAAGGGCTGCATGAAAATTCAGTTCGTCTCTCCAGACAGCTTCGGCGCATCCTT
TTGCCCCTGTATGAGGTTGATGACTTACGAGACGCATTTCGTACTTTGGGACTTTGA

# Metabolic_Enzyme_38_GenBank_ID_Gene:
AB040431

# Metabolic_Enzyme_38_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_38_Locus:
12p13

# Metabolic_Enzyme_38_SNPs:
rs2028373; rs12307097; rs11046349; rs7304723; rs2580874; rs2518144; rs2580873; rs1561560; rs2580875; rs12306110; rs1561559; rs2580876; rs3794318; rs17792729; rs1347978; rs3794316; rs1439868; rs2165191; rs3794317; rs11613792; rs1561562; rs1561561; rs714629; rs7316523; rs9971686; rs1561557; rs12297074; rs2019057; rs9971703; rs714630; rs3205190; rs10601618; rs34604633; rs11324989; rs7138990; rs35273657; rs10623739; rs12310085; rs28681214; rs11614281; rs5796316; rs1439869; rs12307620; rs34730872; rs12312451; rs5796317; rs33998240; rs35699718; rs1982214; rs12321976; rs34030304; rs1561558; rs1345004; rs9971705; rs28835914; rs12321209; rs12824576; rs2889653; rs7305961; rs7306108

# Metabolic_Enzyme_38_General_References:
10950930; 11007475; 11544457

# Metabolic_Enzyme_38_References:
Not Available

# Metabolic_Enzyme_39_ID:
5960

# Metabolic_Enzyme_39_Name:
Protein-arginine deiminase type-1

# Metabolic_Enzyme_39_Synonyms:
Protein-arginine deiminase type I; Peptidylarginine deiminase I

# Metabolic_Enzyme_39_Gene_Name:
PADI1

# Metabolic_Enzyme_39_Protein_Sequence:
>Proteinarginine deiminase type1
MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVK
EPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLE
VDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDM
SPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVER
QPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNT
QPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIE
APHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTV
GGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFV
PTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDN
LHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPK
PYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWN
MVP

# Metabolic_Enzyme_39_Number_of_Residues:
663

# Metabolic_Enzyme_39_Molecular_Weight:
74666

# Metabolic_Enzyme_39_Theoretical_pI:
6.46

# Metabolic_Enzyme_39_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Function:  protein-arginine deiminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_39_General_Function:
Not Available

# Metabolic_Enzyme_39_Specific_Function:
Catalyzes the deimination of arginine residues of proteins

# Metabolic_Enzyme_39_Pathway:
Not Available

# Metabolic_Enzyme_39_Reaction:
protein L-arginine + H2O = protein L-citrulline + NH3

# Metabolic_Enzyme_39_Pfam_Domain_Function:
PF03068:PAD;
PF08527:PAD_M;
PF08526:PAD_N

# Metabolic_Enzyme_39_Signals:
1-17

# Metabolic_Enzyme_39_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_39_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_39_EC_Link:
EC 3.5.3.15

# Metabolic_Enzyme_39_GenBank_ID_Protein:
6116899

# Metabolic_Enzyme_39_SwissProt_ID:
PADI1_HUMAN (Q9ULC6)

# Metabolic_Enzyme_39_swissprot_Name:
Not Available

# Metabolic_Enzyme_39_Genecard_id:
PADI1

# Metabolic_Enzyme_39_Geneatlas_id:
PADI1

# Metabolic_Enzyme_39_hgnc_id:
HGNC:18367

# Metabolic_Enzyme_39_PDB_ID:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_39_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_39_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_39_Gene_Sequence:
>1992 bp
ATGGCCCCAAAGAGAGTTGTGCAGCTGTCCCTGAAGATGCCTACCCATGCCGTGTGTGTG
GTGGGAGTCGAGGCACATGTGGACATTCACAGTGATGTGCCCAAGGGTGCCAACAGCTTC
AGGGTCTCTGGAAGCTCCGGGGTGGAGGTCTTCATGGTCTACAACCGCACACGTGTGAAA
GAGCCCATAGGCAAGGCCCGTTGGCCGCTAGACACTGATGCAGACATGGTCGTATCTGTG
GGCACAGCCAGTAAGGAATTAAAGGACTTCAAGGTGAGGGTCTCCTACTTTGGGGAGCAG
GAAGACCAAGCTCTGGGCCGCAGCGTGCTTTACCTCACTGGCGTCGATATTTCCCTTGAG
GTTGACACAGGCCGCACAGGCAAGGTGAAGAGGAGCCAAGGGGACAAGAAAACCTGGCGC
TGGGGCCCTGAGGGCTATGGGGCTATCTTGCTGGTGAACTGTGACCGGGACAATCACAGG
TCCGCGGAGCCTGACCTCACCCACAGCTGGCTGATGTCGCTGGCTGACCTGCAGGACATG
TCCCCAATGCTGCTGAGCTGCAATGGCCCCGACAAGCTCTTCGACAGCCACAAGCTTGTC
TTGAACGTGCCCTTTTCTGATTCCAAAAGAGTGAGGGTCTTCTGTGCCAGGGGTGGGAAT
TCTCTCTCGGACTACAAACAGGTGCTGGGGCCCCAGTGTCTGTCCTATGAAGTTGAGCGA
CAGCCAGGGGAGCAGGAGATCAAGTTCTATGTGGAGGGGCTGACCTTCCCCGATGCCGAT
TTCCTAGGGCTGGTTTCCCTCAGTGTCAGCCTGGTGGACCCGGGGACCCTGCCCGAGGTG
ACCCTCTTCACAGACACTGTGGGCTTCCGCATGGCCCCCTGGATCATGACGCCCAACACT
CAGCCTCCTGAGGAGCTGTATGTGTGCAGAGTGATGGACACTCATGGCTCCAATGAGAAA
TTCCTGGAGGACATGTCTTATCTGACATTGAAAGCCAACTGCAAGCTGACCATCTGCCCT
CAAGTTGAAAATCGAAATGACCGCTGGATCCAGGACGAGATGGAGTTTGGCTACATCGAG
GCCCCTCACAAATCCTTCCCCGTGGTCTTTGACTCCCCCAGGAACAGGGGCCTGAAAGAT
TTCCCCTATAAGAGGATCCTGGGTCCTGACTTTGGATATGTTACCCGGGAGATCCCGCTC
CCTGGTCCCTCCAGCCTTGACTCCTTCGGCAACCTGGACGTCAGCCCGCCCGTCACGGGG
GGCGGCACGGAATACCCCCTGGGCCGGATCCTCATCGGGAGCAGCTTCCCCAAGTCCGGT
GGGCGGCAGATGGCCAGGGCAGTGCGGAACTTCCTGAAGGCACAGCAGGTGCAGGCACCC
GTGGAGCTCTACTCGGACTGGCTCTCTGTGGGCCATGTGGACGAGTTTCTGACCTTTGTG
CCTACCTCTGACCAGAAGGGCTTCCGGCTGCTCCTGGCTAGCCCCAGCGCTTGCCCCAAA
CTCTTCCAAGAGAAGAAAGAAGAGGGTTATGGGGAGGCAGCCCAGTTTGATGGGTTAAAA
CACCAGGCAAAAAGAAGCATTAATGAGATGCTGGCAGACAGACACCTCCAGAGAGACAAT
CTTCATGCACAGAAATGCATTGACTGGAACCGTAATGTGCTGAAGCGGGAGCTGGGCCTG
GCAGAGAGTGACATCGTGGACATTCCCCAGCTCTTCTTCCTGAAAAACTTCTACGCGGAA
GCCTTCTTCCCAGACATGGTTAACATGGTGGTCTTAGGCAAGTACCTGGGCATCCCCAAG
CCCTACGGGCCCATCATCAATGGCCGCTGCTGCCTGGAGGAGAAGGTGCAGTCCCTGCTG
GAGCCTCTGGGCCTGCACTGCATCTTCATTGATGACTACTTGTCCTACCACGAGCTGCAG
GGGGAGATCCACTGTGGCACCAACGTGCGCAGGAAGCCCTTTCCCTTCAAATGGTGGAAC
ATGGTGCCCTGA

# Metabolic_Enzyme_39_GenBank_ID_Gene:
AB033768

# Metabolic_Enzyme_39_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_39_Locus:
1p36.13

# Metabolic_Enzyme_39_SNPs:
rs16824215; rs2293912; rs3003406; rs2977234; rs11590783; rs2293911; rs3750299; rs2293915; rs3003412; rs2977235; rs2977284; rs2977222; rs2977290; rs3003479; rs4309027; rs6667138; rs3750296; rs11203332; rs6687052; rs4920359; rs4384275; rs2293913; rs2977277; rs12096215; rs12024174; rs11203339; rs2977233; rs12030076; rs12057156; rs11203336; rs2293921; rs4268393; rs3763583; rs3003413; rs2977279; rs2293914; rs10888010; rs2977236; rs2977307; rs2977312; rs16823950; rs3003407; rs2977274; rs3003478; rs11203334; rs3123531; rs2008313; rs10127662; rs3750297; rs3003414; rs2977278; rs11589046; rs11588921; rs2977313; rs3123532; rs3003409; rs12028888; rs2977272; rs2977283; rs2977238; rs4920575; rs10749617; rs3115788; rs12091488; rs4920576; rs3003408; rs3003480; rs3003482; rs11577718; rs2977310; rs3750295; rs4920358; rs2977309; rs10888008; rs2977270; rs4244378; rs11800455; rs2977286; rs12026071; rs12138305; rs2977280; rs2977308; rs878508; rs4244377; rs2977237; rs4376784; rs12135995; rs6679572; rs16823620; rs12086890; rs2977285; rs12125350; rs6682569; rs2977273; rs6674583; rs6682573; rs16824005; rs12408716; rs12024177; rs11203340; rs3003481; rs3115789; rs12096884; rs2977271; rs12087943; rs12044142; rs16823615; rs12401313; rs12042390; rs2977306; rs9970134; rs6656786; rs16823998; rs10888009; rs3750292; rs12119803; rs2977282; rs10888007; rs2293910; rs12073445; rs6665128; rs4920571; rs28706570; rs41265071; rs11203335; rs41265069; rs41300110; rs3003415; rs6679574; rs12735518; rs34130414; rs2977291; rs41265067; rs12086331; rs4994417; rs35549923; rs2977223; rs35408430; rs12082617; rs6143143; rs35930248; rs34306509; rs12097011; rs3003411; rs34749160; rs3003418; rs12042325; rs34512660; rs34284844; rs12042639; rs11203337; rs35924964; rs12080690; rs35818130; rs9970436; rs11588976; rs3003477; rs11203338; rs41265091; rs35756262; rs35665599; rs34703588; rs12730578; rs2977288; rs1006624; rs34647130; rs41265085; rs3003410; rs12746163; rs9919187; rs12046183; rs34961969; rs2977289; rs6681682; rs11267550; rs35593058; rs35573454; rs11576788; rs41265087; rs12735533; rs12062009; rs12081883; rs3763581; rs2977287; rs3003405; rs35823191; rs35724119; rs10538547; rs34562036; rs3003417; rs12135648; rs34182672; rs12730593; rs34242337; rs12729847; rs12082663; rs34739449; rs12730570; rs12752579; rs2977311; rs41265089; rs11203341; rs35500545; rs35116152; rs34169516; rs3003416; rs35269235; rs11579051; rs12134684; rs35482193; rs35854535; rs34799498; rs35372998; rs1012858; rs1015082; rs11203343; rs11581288; rs11581367; rs11583460; rs11583594; rs11583629; rs11584147; rs12025184; rs12058442; rs12065629; rs12072538; rs12077061; rs12077067; rs12129306; rs12404500; rs12562867; rs16824388; rs16824389; rs2454181; rs2454182; rs2501820; rs2935940; rs2935941; rs2977224; rs2977225; rs2977227; rs2977228; rs2977229; rs2977230; rs2977256; rs2977257; rs2977259; rs2977262; rs3003419; rs3003422; rs3003423; rs3003424; rs3003470; rs3003471; rs3003472; rs3003473; rs3003474; rs3003476; rs3763587; rs3763589; rs4451590; rs4462198; rs4494184; rs4920570; rs4920578; rs4920579; rs4920580; rs4920581; rs4920582; rs4920583; rs4920584; rs6586512; rs6673643; rs6694161; rs7522439; rs754171; rs873319; rs873320; rs873321; rs9803868

# Metabolic_Enzyme_39_General_References:
Not Available

# Metabolic_Enzyme_39_References:
Not Available

# Metabolic_Enzyme_40_ID:
5961

# Metabolic_Enzyme_40_Name:
Aminomethyltransferase, mitochondrial precursor

# Metabolic_Enzyme_40_Synonyms:
Glycine cleavage system T protein; GCVT

# Metabolic_Enzyme_40_Gene_Name:
AMT

# Metabolic_Enzyme_40_Protein_Sequence:
>Aminomethyltransferase, mitochondrial precursor
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK

# Metabolic_Enzyme_40_Number_of_Residues:
403

# Metabolic_Enzyme_40_Molecular_Weight:
43947

# Metabolic_Enzyme_40_Theoretical_pI:
8.69

# Metabolic_Enzyme_40_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring one-carbon groups
Function:  methyltransferase activity
Function:  aminomethyltransferase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
Process:  serine family amino acid metabolism
Process:  glycine metabolism
Process:  glycine catabolism
 ||
>>>
Component:  cell
Component:  intracellular
Component:  cytoplasm

# Metabolic_Enzyme_40_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_40_Specific_Function:
The glycine cleavage system catalyzes the degradation of glycine

# Metabolic_Enzyme_40_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00670  One carbon pool by folate;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_40_Reaction:
protein-S-aminomethyldihydrolipoyllysine + tetrahydrofolate = protein-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3

# Metabolic_Enzyme_40_Pfam_Domain_Function:
PF01571:GCV_T;
PF08669:GCV_T_C

# Metabolic_Enzyme_40_Signals:
1-23

# Metabolic_Enzyme_40_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_40_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_40_EC_Link:
EC 2.1.2.10

# Metabolic_Enzyme_40_GenBank_ID_Protein:
391721

# Metabolic_Enzyme_40_SwissProt_ID:
GCST_HUMAN (P48728)

# Metabolic_Enzyme_40_swissprot_Name:
Not Available

# Metabolic_Enzyme_40_Genecard_id:
AMT

# Metabolic_Enzyme_40_Geneatlas_id:
AMT

# Metabolic_Enzyme_40_hgnc_id:
HGNC:473

# Metabolic_Enzyme_40_PDB_ID:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_40_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_40_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_40_Gene_Sequence:
>1212 bp
ATGCAGAGGGCTGTAAGTGTGGTGGCCCGTCTGGGCTTTCGCCTGCAGGCATTCCCCCCG
GCCTTGTGTCGTCCACTTAGTTGCGCACAGGAGGTGCTCCGCAGGACACCGCTCTATGAC
TTCCACCTGGCCCACGGCGGGAAAATGGTGGCGTTTGCGGGTTGGAGTCTGCCAGTGCAG
TACCGGGACAGTCACACTGACTCGCACCTGCACACACGCCAGCACTGCTCGCTCTTTGAC
GTGTCTCATATGCTGCAGACCAAGATACTTGGTAGTGACCGGGTGAAGCTGATGGAGAGT
CTAGTGGTTGGAGACATTGCAGAGCTAAGACCAAACCAGGGGACACTGTCGCTGTTTACC
AACGAGGCTGGAGGCATCTTAGATGACTTGATTGTAACCAATACTTCTGAGGGCCACCTG
TATGTGGTGTCCAACGCTGGCTGCTGGGAGAAAGATTTGGCCCTCATGCAGGACAAGGTC
AGGGAGCTTCAGAACCAGGGCAGAGATGTGGGCCTGGAGGTGTTGGATAATGCCCTGCTA
GCTCTGCAAGGCCCCACTGCAGCCCAGGTACTACAGGCCGGCGTGGCAGATGACCTGAGG
AAACTGCCCTTCATGACCAGTGCTGTGATGGAGGTGTTTGGCGTGTCTGGCTGCCGCGTG
ACCCGCTGTGGCTACACAGGAGAGGATGGTGTGGAGATCTCGGTGCCGGTAGCGGGGGCA
GTTCACCTGGCAACAGCTATTCTGAAAAACCCAGAGGTGAAGCTGGCAGGGCTGGCAGCC
AGGGACAGCCTGCGCCTGGAGGCAGGCCTCTGCCTGTATGGGAATGACATTGATGAACAC
ACTACACCTGTGGAGGGCAGCCTCAGTTGGACACTGGGGAAGCGCCGCCGAGCTGCTATG
GACTTCCCTGGAGCCAAGGTCATTGTTCCCCAGCTGAAGGGCAGGGTGCAGCGGAGGCGT
GTGGGGTTGATGTGTGAGGGGGCCCCCATGCGGGCACACAGTCCCATCCTGAACATGGAG
GGTACCAAGATTGGTACTGTGACTAGTGGCTGCCCCTCCCCCTCTCTGAAGAAGAATGTG
GCGATGGGTTATGTGCCCTGCGAGTACAGTCGTCCAGGGACAATGCTGCTGGTAGAGGTG
CGGCGGAAGCAGCAGATGGCTGTAGTCAGCAAGATGCCCTTTGTGCCCACAAACTACTAT
ACCCTCAAGTGA

# Metabolic_Enzyme_40_GenBank_ID_Gene:
D13811

# Metabolic_Enzyme_40_Chromosome_Location:
Chromosome:3

# Metabolic_Enzyme_40_Locus:
3p21.2-p21.1

# Metabolic_Enzyme_40_SNPs:
rs11715915; rs1464567; rs1464568; rs4855873; rs9859556; rs11922013; rs1041964; rs34568346; rs13095834; rs3049036; rs34457565; rs35024166; rs11425937; rs10640; rs11130192; rs11710609; rs1464566; rs1464569; rs1522929; rs1803637; rs1996874; rs34812788; rs4855874; rs4855877; rs6446272; rs6446273; rs6762593; rs6779432; rs6779524; rs6784820; rs6997; rs8897; rs940045; rs9814873

# Metabolic_Enzyme_40_General_References:
7916605; 8188235; 8005589; 9600239; 9621520; 10873393; 11286506

# Metabolic_Enzyme_40_References:
Not Available

# Metabolic_Enzyme_41_ID:
5962

# Metabolic_Enzyme_41_Name:
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

# Metabolic_Enzyme_41_Synonyms:
Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; GAPDH-2

# Metabolic_Enzyme_41_Gene_Name:
GAPDHS

# Metabolic_Enzyme_41_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase, testisspecific
MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPKAEVEPQPQPEPTPVREEIKPPPPPLPP
HPATPPPKMVSVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKY
DSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAAS
DHISAGAQRVVISAPSPDAPMFVMGVNENDYNPGSMNIVSNASCTTNCLAPLAKVIHERF
GIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKL
TGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTEDEVVSTDFLG
DTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK

# Metabolic_Enzyme_41_Number_of_Residues:
408

# Metabolic_Enzyme_41_Molecular_Weight:
44502

# Metabolic_Enzyme_41_Theoretical_pI:
8.34

# Metabolic_Enzyme_41_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_41_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_41_Specific_Function:
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility

# Metabolic_Enzyme_41_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_41_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_41_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_41_Signals:
None

# Metabolic_Enzyme_41_Transmembrane_Regions:
None

# Metabolic_Enzyme_41_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_41_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_41_GenBank_ID_Protein:
3046742

# Metabolic_Enzyme_41_SwissProt_ID:
G3PT_HUMAN (O14556)

# Metabolic_Enzyme_41_swissprot_Name:
Not Available

# Metabolic_Enzyme_41_Genecard_id:
GAPDHS

# Metabolic_Enzyme_41_Geneatlas_id:
GAPDHS

# Metabolic_Enzyme_41_hgnc_id:
HGNC:24864

# Metabolic_Enzyme_41_PDB_ID:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_41_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_41_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_41_Gene_Sequence:
>1227 bp
ATGTCGAAGCGCGACATCGTCCTCACCAATGTCACCGTTGTCCAGTTGCTGCGACAGCCG
TGCCCGGTGACCAGAGCACCGCCCCCACCTGAGCCTAAGGCTGAAGTAGAGCCCCAGCCA
CAACCAGAGCCCACACCAGTCAGGGAGGAAATAAAGCCACCACCGCCACCACTGCCTCCT
CACCCCGCTACTCCTCCTCCTAAGATGGTGTCTGTGGCCCGGGAGCTGACTGTGGGCATC
AATGGATTTGGACGCATCGGTCGCCTGGTCCTGCGCGCCTGCATGGAGAAGGGTGTTAAG
GTGGTGGCTGTGAATGATCCATTCATTGACCCGGAATACATGGTGTACATGTTTAAGTAT
GACTCCACCCACGGCCGATACAAGGGAAGTGTGGAATTCAGGAATGGACAACTGGTCGTG
GACAACCATGAGATCTCTGTCTACCAGTGCAAAGAGCCCAAACAGATCCCCTGGAGGGCT
GTCGGGAGCCCCTACGTGGTGGAGTCCACAGGCGTGTACCTCTCCATACAGGCAGCTTCG
GACCACATCTCTGCAGGTGCTCAACGTGTGGTCATCTCCGCGCCCTCACCGGATGCACCA
ATGTTCGTCATGGGTGTCAATGAAAATGACTATAACCCTGGCTCCATGAACATTGTGAGC
AACGCGTCCTGCACCACCAACTGTTTGGCTCCCCTCGCCAAAGTCATCCACGAGCGATTT
GGGATCGTGGAAGGGTTGATGACCACAGTCCATTCCTACACGGCCACCCAGAAGACAGTG
GACGGGCCATCAAGGAAGGCCTGGCGAGATGGGCGGGGTGCCCACCAGAACATCATCCCA
GCCTCCACTGGGGCTGCGAAAGCTGTGACCAAAGTCATCCCAGAGCTCAAAGGGAAGCTG
ACAGGGATGGCGTTCCGGGTACCAACCCCGGATGTGTCTGTCGTGGACCTGACCTGCCGC
CTCGCCCAGCCTGCCCCCTACTCAGCCATCAAGGAGGCTGTAAAAGCAGCAGCCAAGGGG
CCCATGGCTGGCATCCTTGCCTACACCGAGGATGAGGTCGTCTCTACGGACTTCCTCGGT
GATACCCACTCGTCCATCTTCGATGCTAAGGCCGGCATTGCGCTCAATGACAATTTCGTG
AAGCTCATTTCATGGTACGACAACGAATATGGCTACAGTCACCGGGTGGTCGACCTCCTC
CGCTACATGTTCAGCCGAGACAAGTGA

# Metabolic_Enzyme_41_GenBank_ID_Gene:
AJ005371

# Metabolic_Enzyme_41_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_41_Locus:
19q13.1

# Metabolic_Enzyme_41_SNPs:
rs2239945; rs4806173; rs8100526; rs4806174; rs2239942; rs17705657; rs11882238; rs2293681; rs2239943; rs2871992; rs2239944; rs12984928; rs11668508; rs4806171; rs12608794; rs12151019; rs12151182; rs12150953; rs2285514; rs11882298; rs4442931; rs12985222; rs35758620; rs35395050; rs28590024; rs35558737; rs12985178; rs10532876; rs12978688; rs11084822; rs3216892; rs11403940; rs34411155; rs34297540; rs34305005; rs34495996; rs1029387; rs10420102; rs1044255; rs10775583; rs1127675; rs11878600; rs12611120; rs1269215; rs12977572; rs16970510; rs17638427; rs17705633; rs17776451; rs2251124; rs2251125; rs2285511; rs2285512; rs2285513; rs2301617; rs2733738; rs2733739; rs2733744; rs2854252; rs34044708; rs34081785; rs35486099; rs35586120; rs3815018; rs4805129; rs7599; rs759996; rs8112853

# Metabolic_Enzyme_41_General_References:
10714828

# Metabolic_Enzyme_41_References:
Not Available

# Metabolic_Enzyme_42_ID:
5789

# Metabolic_Enzyme_42_Name:
Cystathionine gamma-lyase

# Metabolic_Enzyme_42_Synonyms:
Gamma-cystathionase

# Metabolic_Enzyme_42_Gene_Name:
CTH

# Metabolic_Enzyme_42_Protein_Sequence:
>Cystathionine gammalyase
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS

# Metabolic_Enzyme_42_Number_of_Residues:
405

# Metabolic_Enzyme_42_Molecular_Weight:
44508

# Metabolic_Enzyme_42_Theoretical_pI:
6.69

# Metabolic_Enzyme_42_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_42_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_42_Specific_Function:
L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

# Metabolic_Enzyme_42_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00271  Methionine metabolism;
 map00272  Cysteine metabolism;
 map00450  Selenoamino acid metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_42_Reaction:
L-cystathionine + H2O = L-cysteine + ammonia + 2-oxobutanoate

# Metabolic_Enzyme_42_Pfam_Domain_Function:
PF01053:Cys_Met_Meta_PP

# Metabolic_Enzyme_42_Signals:
None

# Metabolic_Enzyme_42_Transmembrane_Regions:
None

# Metabolic_Enzyme_42_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_42_EC_Link:
EC 4.4.1.1

# Metabolic_Enzyme_42_GenBank_ID_Protein:
262476

# Metabolic_Enzyme_42_SwissProt_ID:
CGL_HUMAN (P32929)

# Metabolic_Enzyme_42_swissprot_Name:
Not Available

# Metabolic_Enzyme_42_Genecard_id:
CTH

# Metabolic_Enzyme_42_Geneatlas_id:
CTH

# Metabolic_Enzyme_42_hgnc_id:
HGNC:2501

# Metabolic_Enzyme_42_PDB_ID:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_42_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_42_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_42_Gene_Sequence:
>1218 bp
ATGCAGGAAAAAGACGCCTCCTCACAAGGTTTCCTGCCACACTTCCAACATTTCGCCACG
CAGGCGATCCATGTGGGCCAGGATCCGGAGCAATGGACCTCCAGGGCTGTAGTGCCCCCC
ATCTCACTGTCCACCACGTTCAAGCAAGGGGCGCCTGGCCAGCACTCGGGTTTTGAATAT
AGCCGTTCTGGAAATCCCACTAGGAATTGCCTTGAAAAAGCAGTGGCAGCACTGGATGGG
GCTAAGTACTGTTTGGCCTTTGCTTCAGGTTTAGCAGCCACTGTAACTATTACCCATCTT
TTAAAAGCAGGAGACCAAATTATTTGTATGGATGATGTGTATGGAGGTACAAACAGGTAC
TTCAGGCAAGTGGCATCTGAATTTGGATTAAAGATTTCTTTTGTTGATTGTTCCAAAATC
AAATTACTAGAGGCAGCAATTACACCAGAAACCAAGCTTGTTTGGATCGAAACCCCCACA
AACCCCACCCAGAAGGTGATTGACATTGAAGGCTGTGCACATATTGTCCATAAGCATGGA
GACATTATTTTGGTCGTGGATAACACTTTTATGTCACCATATTTCCAGCGCCCTTTGGCT
CTGGGAGCTGATATTTCTATGTATTCTGCAACAAAATACATGAATGGCCACAGTGATGTT
GTAATGGGCCTGGTGTCTGTTAATTGTGAAAGCCTTCATAATAGACTTCGTTTCTTGCAA
AACTCTCTTGGAGCAGTTCCATCTCCTATTGATTGTTACCTCTGCAATCGAGGTCTGAAG
ACTCTACATGTCCGAATGGAAAAGCATTTCAAAAACGGAATGGCAGTTGCCCAGTTCCTG
GAATCTAATCCTTGGGTAGAAAAGGTTATTTATCCTGGGCTGCCCTCTCATCCACAGCAT
GAGTTGGTGAAGCGTCAGTGTACAGGTTGTACAGGGATGGTCACCTTTTATATTAAGGGC
ACTCTTCAGCATGCTGAGATTTTCCTCAAGAACCTAAAGCTATTTACTCTGGCCGAGAGC
TTGGGAGGATTCGAAAGCCTTGCTGAGCTTCCGGCAATCATGACTCATGCATCAGTTCTT
AAGAATGACAGAGATGTCCTTGGAATTAGTGACACACTGATTCGACTTTCTGTGGGCTTA
GAGGATGAGGAAGACCTACTGGAAGATCTAGATCAAGCTTTGAAGGCAGCACACCCTCCA
AGTGGAATTCACAGCTAG

# Metabolic_Enzyme_42_GenBank_ID_Gene:
S52784

# Metabolic_Enzyme_42_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_42_Locus:
1p31.1

# Metabolic_Enzyme_42_SNPs:
rs1021737; rs17131292; rs535112; rs672203; rs663649; rs515064; rs473334; rs681475; rs481654; rs1145920; rs525919; rs6413469; rs4650049; rs525276; rs475263; rs12723350; rs543860; rs1145919; rs487773; rs490574; rs559062; rs501939; rs577476; rs6413471; rs482291; rs3767205; rs11800827; rs12047791; rs12566819; rs35173672; rs6413472; rs1831868; rs34538135; rs35523269; rs35441160; rs828355; rs17131305; rs35356635; rs608609; rs35864483; rs35242276; rs10889869; rs12037405; rs12030275; rs36032119; rs34044393; rs6413470; rs7418870; rs17131304; rs35873591; rs1831869; rs17131302; rs6693082; rs663465; rs648743; rs6677781; rs583316; rs6413468; rs12733999; rs3806385; rs17131290; rs584229; rs28595301; rs41305638; rs28498802; rs12134794; rs4650048; rs11295998; rs10583561; rs17131300; rs6703826; rs7367528; rs5775007; rs34806645; rs41313347; rs12134791; rs35200485; rs11589868; rs12134763; rs35769653; rs6657511; rs10607278; rs12141277; rs34046663; rs11413197; rs34328255; rs6657715; rs34566720; rs34937471; rs34141704; rs35782843; rs5775006; rs4323657; rs13374865; rs12134858; rs12753345; rs562660; rs6413473; rs4649915; rs12133065; rs35606808; rs35199704; rs12134857; rs12124009; rs34612780; rs34825234; rs36059149; rs34311111; rs34465384; rs36065609; rs11590089; rs11803055; rs12026422; rs12063280; rs12093763; rs12561944; rs12728599; rs1697388; rs17131275; rs17131276; rs17131277; rs17131278; rs17131280; rs17131282; rs17131285; rs17131286; rs17131287; rs17131288; rs17131289; rs17131312; rs2151540; rs3856027; rs3856028; rs4650047; rs4650050; rs482843; rs508310; rs517500; rs555671; rs561926; rs618531; rs6424386; rs649346; rs664051; rs7515490; rs7537371; rs7549628

# Metabolic_Enzyme_42_General_References:
1339280; 12574942

# Metabolic_Enzyme_42_References:
Not Available

# Metabolic_Enzyme_43_ID:
5963

# Metabolic_Enzyme_43_Name:
Guanine deaminase

# Metabolic_Enzyme_43_Synonyms:
Guanase; Guanine aminase; Guanine aminohydrolase; GAH; p51-nedasin

# Metabolic_Enzyme_43_Gene_Name:
GDA

# Metabolic_Enzyme_43_Protein_Sequence:
>Guanine deaminase
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

# Metabolic_Enzyme_43_Number_of_Residues:
454

# Metabolic_Enzyme_43_Molecular_Weight:
51004

# Metabolic_Enzyme_43_Theoretical_pI:
5.45

# Metabolic_Enzyme_43_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_43_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_43_Specific_Function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

# Metabolic_Enzyme_43_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_43_Reaction:
guanine + H2O = xanthine + ammonia

# Metabolic_Enzyme_43_Pfam_Domain_Function:
PF01979:Amidohydro_1

# Metabolic_Enzyme_43_Signals:
None

# Metabolic_Enzyme_43_Transmembrane_Regions:
None

# Metabolic_Enzyme_43_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_43_EC_Link:
EC 3.5.4.3

# Metabolic_Enzyme_43_GenBank_ID_Protein:
4588080

# Metabolic_Enzyme_43_SwissProt_ID:
GUAD_HUMAN (Q9Y2T3)

# Metabolic_Enzyme_43_swissprot_Name:
Not Available

# Metabolic_Enzyme_43_Genecard_id:
GDA

# Metabolic_Enzyme_43_Geneatlas_id:
GDA

# Metabolic_Enzyme_43_hgnc_id:
HGNC:4212

# Metabolic_Enzyme_43_PDB_ID:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_43_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_43_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_43_Gene_Sequence:
>1365 bp
ATGTGTGCCGCTCAGATGCCGCCCCTGGCGCACATCTTCCGAGGGACGTTCGTCCACTCC
ACCTGGACCTGCCCCATGGAGGTGCTGCGGGATCACCTCCTCGGCGTGAGCGACAGCGGC
AAAATAGTGTTTTTAGAAGAAGCATCTCAACAGGAAAAACTGGCCAAAGAATGGTGCTTC
AAGCCGTGTGAAATAAGAGAACTGAGCCACCATGAGTTCTTCATGCCTGGGCTGGTTGAT
ACACACATCCATGCCTCTCAGTATTCCTTTGCTGGAAGTAGCATAGACCTGCCACTCTTG
GAGTGGCTGACCAAGTACACATTTCCTGCAGAACACAGATTCCAGAACATCGACTTTGCA
GAAGAAGTATATACCAGAGTTGTCAGGAGAACACTAAAGAATGGAACAACCACAGCTTGT
TACTTTGCAACAATTCACACTGACTCATCTCTGCTCCTTGCCGACATTACAGATAAATTT
GGACAGCGGGCATTTGTGGGCAAAGTTTGCATGGATTTGAATGACACTTTTCCAGAATAC
AAGGAGACCACTGAGGAATCGATCAAGGAAACTGAGAGATTTGTGTCAGAAATGCTCCAA
AAGAACTATTCTAGAGTGAAGCCCATAGTGACACCACGTTTTTCCCTCTCCTGCTCTGAG
ACTTTGATGGGTGAACTGGGCAACATTGCTAAAACCCGTGATTTGCACATTCAGAGCCAT
ATAAGTGAAAATCGTGATGAAGTTGAAGCTGTGAAAAACTTATACCCCAGTTATAAAAAC
TACACATCTGTGTATGATAAAAACAATCTTTTGACAAATAAGACAGTGATGGCACACGGC
TGCTACCTCTCTGCAGAAGAACTGAACGTATTCCATGAACGAGGAGCATCCATCGCACAC
TGTCCCAATTCTAATTTATCGCTCAGCAGTGGATTTCTAAATGTGCTAGAAGTCCTGAAA
CATGAAGTCAAGATAGGGCTGGGTACAGACGTGGCTGGTGGCTATTCATATTCCATGCTT
GATGCAATCAGAAGAGCAGTGATGGTTTCCAATATCCTTTTAATTAATAAGGTAAATGAG
AAAAGCCTCACCCTCAAAGAAGTCTTCAGACTAGCTACTCTTGGAGGAAGCCAAGCCCTG
GGGCTGGATGGTGAGATTGGAAACTTTGAAGTGGGCAAGGAATTTGATGCCATCCTGATC
AACCCCAAAGCATCCGACTCTCCCATTGACCTGTTTTATGGGGACTTTTTTGGTGATATT
TCTGAGGCTGTTATCCAGAAGTTCCTCTATCTAGGAGATGATCGAAATATTGAAGAGGTT
TATGTGGGCGGAAAGCAGGTGGTTCCGTTTTCCAGCTCAGTGTAA

# Metabolic_Enzyme_43_GenBank_ID_Gene:
AF095286

# Metabolic_Enzyme_43_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_43_Locus:
9q21.13

# Metabolic_Enzyme_43_SNPs:
rs2208744; rs1123; rs4484759; rs7029873; rs7038786; rs6560259; rs11143168; rs10869149; rs4579592; rs10869150; rs4744663; rs11143170; rs7030578; rs10869148; rs10781089; rs4314712; rs7862279; rs10781082; rs7031258; rs11143193; rs10781090; rs10869151; rs4130867; rs7874671; rs10781077; rs7023949; rs10781079; rs7030035; rs10869130; rs7853683; rs11143155; rs7019328; rs13298434; rs10869142; rs10781084; rs17494144; rs10781086; rs4130866; rs13284274; rs12338453; rs11143162; rs7019060; rs11143145; rs7861301; rs10781078; rs10735614; rs4545160; rs11143141; rs10746905; rs17494172; rs7025700; rs10781088; rs17057544; rs7048306; rs4745175; rs10869135; rs4503167; rs11143175; rs11143143; rs7862343; rs17579467; rs7867133; rs4540461; rs4427235; rs7857832; rs17494835; rs17579544; rs10781085; rs10781083; rs11143198; rs6560255; rs11143176; rs7032697; rs7849653; rs10869137; rs10781087; rs10869136; rs17057536; rs11143200; rs11143169; rs2295902; rs12343189; rs11143192; rs10869140; rs12347198; rs10869134; rs4745176; rs7847604; rs12380886; rs10122641; rs11143190; rs10869133; rs11143181; rs7048302; rs7036326; rs7862991; rs7868844; rs7019189; rs13292413; rs11143187; rs4618766; rs7043791; rs7847150; rs17579286; rs4287006; rs10869138; rs7873543; rs7863465; rs12379746; rs11143178; rs11143139; rs7872576; rs4607679; rs11143164; rs7024598; rs7872253; rs12000573; rs11143136; rs10869131; rs12684664; rs11143160; rs7851247; rs12555257; rs7866644; rs10735615; rs11143150; rs10746906; rs11143188; rs10869141; rs11143183; rs11790220; rs4745178; rs12000375; rs11143174; rs7027274; rs10869139; rs11143180; rs7023029; rs12341210; rs7863894; rs5025470; rs17057532; rs13295564; rs10869143; rs17057547; rs7039714; rs17494333; rs11143186; rs7034285; rs7847039; rs12551201; rs10781080; rs4347048; rs13439903; rs7862293; rs10869145; rs7870435; rs17057543; rs7034622; rs3802506; rs35577632; rs7023990; rs13298009; rs12551494; rs12684798; rs7848617; rs10869132; rs11143144; rs11143199; rs7863016; rs7848485; rs7036479; rs7021424; rs11143134; rs4745174; rs7042164; rs41287399; rs41310055; rs3830994; rs35479709; rs34771500; rs34826830; rs11143146; rs34464792; rs34994180; rs12340785; rs7030138; rs36108105; rs11143182; rs10120863; rs34896961; rs12236224; rs35055310; rs11143171; rs11143158; rs35815597; rs11143157; rs35560375; rs13286309; rs35376951; rs11143151; rs10544644; rs13289128; rs11143197; rs34517745; rs11143177; rs13301296; rs13285773; rs34453023; rs35580322; rs36066152; rs12336009; rs34935659; rs10869146; rs11143149; rs35080524; rs7868258; rs35540892; rs34401093; rs28894678; rs7023048; rs4132371; rs34172929; rs34039840; rs35534385; rs36023536; rs35976245; rs41287397; rs11143153; rs5898250; rs28595862; rs10588583; rs35929343; rs7868716; rs11310535; rs7028888; rs13286407; rs11143156; rs11327039; rs35402815; rs9695829; rs35490187; rs34627726; rs36053013; rs34208420; rs11793595; rs41287395; rs35963716; rs34340676; rs11143172; rs11442621; rs35458479; rs11143189; rs34611287; rs12347850; rs11143154; rs34151593; rs34139960; rs34656645; rs35345284; rs13294538; rs12683149; rs35587485; rs36095417; rs35458310; rs35936702; rs36057739; rs13292781; rs6560258; rs13301429; rs35524358; rs34395320; rs34584186; rs13299869; rs34271428; rs11143191; rs41287393; rs34922880; rs35383444; rs34193771; rs11143165; rs7041441; rs35909348; rs11143152; rs35111628; rs11143147; rs34847117; rs11143196; rs34236424; rs12339560; rs9696551; rs34248273; rs34537821; rs11411689; rs10566596; rs34979271; rs35740394; rs12339476; rs11143159; rs12238209; rs13299660; rs7046424; rs13299525; rs12376597; rs11143140; rs11310536; rs5898251; rs10588582; rs11143173; rs35059295; rs11143185; rs34971662; rs28735208; rs13299684; rs11143142; rs11143148; rs35948411; rs9775806; rs11788934; rs34554102; rs11794239; rs13290949; rs36110660; rs7862462; rs13284666; rs12237065; rs11143137; rs11143163; rs34354742; rs34021514; rs13290586; rs36027299; rs13283169; rs35528537; rs7861241; rs10548640; rs11143167; rs35547082; rs10614254; rs28723000; rs5898249; rs35288910; rs10714440; rs41287401; rs10116055; rs1040921; rs10511997; rs10781076; rs10781091; rs10869154; rs11143130; rs11143202; rs11143203; rs11143204; rs11143205; rs11788021; rs12001463; rs13283346; rs13287540; rs17057466; rs34380537; rs4745173; rs6560260; rs7029217; rs7030520; rs7047289; rs7849775; rs7850131; rs7850499; rs7863053; rs7863804; rs7868366; rs7868495; rs7869950; rs969460

# Metabolic_Enzyme_43_General_References:
10075721; 10542258

# Metabolic_Enzyme_43_References:
Not Available

# Metabolic_Enzyme_44_ID:
5964

# Metabolic_Enzyme_44_Name:
Protein-glutamine gamma-glutamyltransferase 6

# Metabolic_Enzyme_44_Synonyms:
Transglutaminase-3-like; TGase-3-like; Transglutaminase Y

# Metabolic_Enzyme_44_Gene_Name:
TGM6

# Metabolic_Enzyme_44_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 6
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMET
GPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSS
HRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQG
KYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNS
AHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKI
GRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRC
LWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEK
DITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTL
EPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK

# Metabolic_Enzyme_44_Number_of_Residues:
706

# Metabolic_Enzyme_44_Molecular_Weight:
79313

# Metabolic_Enzyme_44_Theoretical_pI:
7.26

# Metabolic_Enzyme_44_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_44_General_Function:
Not Available

# Metabolic_Enzyme_44_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_44_Pathway:
Not Available

# Metabolic_Enzyme_44_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_44_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_44_Signals:
None

# Metabolic_Enzyme_44_Transmembrane_Regions:
None

# Metabolic_Enzyme_44_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_44_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_44_GenBank_ID_Protein:
33331030

# Metabolic_Enzyme_44_SwissProt_ID:
TGM3L_HUMAN (O95932)

# Metabolic_Enzyme_44_swissprot_Name:
Not Available

# Metabolic_Enzyme_44_Genecard_id:
TGM6

# Metabolic_Enzyme_44_Geneatlas_id:
TGM6

# Metabolic_Enzyme_44_hgnc_id:
HGNC:16255

# Metabolic_Enzyme_44_PDB_ID:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_44_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_44_Subcellular_Location:
Not Available

# Metabolic_Enzyme_44_Gene_Sequence:
>2121 bp
ATGGCAGGGATCAGAGTCACCAAGGTGGACTGGCAGCGGTCGAGGAATGGCGCTGCCCAC
CACACCCAGGAGTACCCCTGCCCTGAGCTGGTGGTTCGCAGGGGCCAGTCGTTCAGCCTC
ACGCTGGAGCTGAGCAGAGCCCTGGACTGTGAGGAGATCCTCATCTTCACGGTGGAGACA
GGACCCCGGGCTTCTGAGGCCCTCCACACCAAAGCTGTGTTCCAGACATCGGAGCTGGAG
CGGGGTGAGGGCTGGACAGCAGCAAGGGAGGCTCAGATGGAGAAAACTCTGACCGTCAGT
CTCGCCAGCCCTCCCAGTGCTGTCATTGGCCGCTACCTGCTGAGCATCAGGCTTTCCTCT
CACCGCAAACACAGCAACCGGAGGCTGGGCGAGTTTGTTCTCCTTTTCAACCCATGGTGT
GCAGAGGACGATGTGTTTCTGGCCTCAGAGGAGGAGAGACAGGAGTACGTGCTCAGCGAC
AGCGGCATCATCTTCCGAGGCGTGGAGAAGCACATACGAGCCCAGGGCTGGAACTACGGG
CAGTTTGAGGAGGACATCCTGAACATCTGCCTCTCCATCCTGGATCGAAGCCCCGGTCAC
CAAAACAACCCAGCCACCGACGTGTCCTGCCGCCACAACCCCATCTACGTCACCAGGGTC
ATCAGTGCCATGGTGAACAGCAACAACGACCGAGGTGTGGTGCAAGGACAGTGGCAGGGC
AAGTACGGCGGCGGCACCAGCCCGCTGCACTGGCGCGGCAGCGTGGCCATTCTGCAGAAG
TGGCTCAAGGGCAGGTACAAGCCAGTCAAGTACGGCCAGTGCTGGGTCTTCGCCGGAGTC
CTGTGCACAGTCCTCAGGTGCTTGGGGATAGCCACACGGGTCGTGTCCAACTTCAACTCA
GCCCACGACACAGACCAGAACCTGAGTGTGGACAAATACGTGGACTCCTTCGGGCGGACC
CTGGAGGACCTGACAGAAGACAGCATGTGGAATTTCCATGTCTGGAATGAGAGCTGGTTT
GCCCGGCAGGACCTAGGCCCCTCTTACAATGGCTGGCAGGTTCTGGATGCCACCCCCCAG
GAGGAGAGTGAAGGTGTGTTCCGGTGCGGCCCAGCCTCAGTCACCGCCATCCGCGAGGGT
GATGTGCACCTGGCTCACGATGGCCCCTTCGTGTTTGCGGAGGTCAACGCCGACTACATC
ACCTGGCTGTGGCACGAGGATGAGAGCCGGGAGCGTGTATACTCAAACACGAAGAAGATT
GGGAGATGCATCAGCACCAAGGCGGTGGGCAGTGACTCCCGCGTGGACATCACTGACCTC
TACAAGTATCCGGAAGGGTCCCGGAAAGAGAGGCAGGTGTACAGCAAGGCGGTGAACAGG
CTGTTCGGCGTGGAAGCCTCTGGAAGGAGAATCTGGATCCGCAGGGCTGGGGGTCGCTGT
CTCTGGCGTGACGACCTCCTGGAGCCTGCCACCAAGCCCAGCATCGCTGGCAAGTTCAAG
GTGCTAGAGCCTCCCATGCTGGGCCACGACCTGAGACTGGCCCTGTGCTTGGCCAACCTC
ACCTCCCGGGCCCAGCGGGTGAGGGTCAACCTGAGCGGTGCCACCATCCTCTATACCCGC
AAGCCAGTGGCAGAGATCCTGCATGAATCCCACGCCGTGAGGCTGGGGCCGCAAGAAGAG
AAGAGAATCCCAATTACAATATCTTACTCTAAGTATAAAGAAGACCTGACAGAGGACAAG
AAGATCCTGTTGGCTGCCATGTGCCTTGTCACCAAAGGAGAGAAGCTTCTGGTGGAGAAG
GACATTACTCTAGAGGACTTCATCACCATCAAGGTTCTGGGCCCAGCCATGGTGGGAGTG
GCAGTTACAGTGGAAGTGACAGTAGTCAACCCCCTCATAGAGAGAGTGAAGGACTGTGCG
CTGATGGTGGAGGGCAGCGGCCTTCTCCAGGAACAGCTCAGCATCGACGTGCCTACCCTG
GAGCCTCAGGAGAGGGCCTCAGTCCAGTTTGACATCACCCCCTCCAAAAGTGGCCCAAGG
CAGCTGCAGGTGGACCTTGTAAGCCCTCACTTCCCGGACATCAAGGGCTTTGTGATCGTC
CATGTGGCCACTGCCAAGTGA

# Metabolic_Enzyme_44_GenBank_ID_Gene:
AF540969

# Metabolic_Enzyme_44_Chromosome_Location:
Chromosome:20

# Metabolic_Enzyme_44_Locus:
20p13

# Metabolic_Enzyme_44_SNPs:
rs2076405; rs6114033; rs2295077; rs16984872; rs2076652; rs2076650; rs7263876; rs3865538; rs6048846; rs6048642; rs2422767; rs2422771; rs8124987; rs1474678; rs2422770; rs2422761; rs2422768; rs3865537; rs8115012; rs13045470; rs2076649; rs2422764; rs6137978; rs6113988; rs2422773; rs4428078; rs6036442; rs6048754; rs8119282; rs6137955; rs2422765; rs2422758; rs2422763; rs6036398; rs6083123; rs2422766; rs6048869; rs6036342; rs6132633; rs2235609; rs2422762; rs2076653; rs1004269; rs6106641; rs2092632; rs6132596; rs2076654; rs11700175; rs2076404; rs6113950; rs6048587; rs2325847; rs4461332; rs2422753; rs6048880; rs6114060; rs6137994; rs6114061; rs742823; rs6132595; rs6137946; rs4404344; rs6036404; rs13037184; rs2092633; rs6036430; rs13040968; rs10485600; rs3865536; rs6048871; rs2422754; rs1967678; rs2422772; rs6036350; rs4441546; rs6048788; rs6106621; rs2179828; rs2092631; rs6114150; rs16984767; rs4053458; rs2325848; rs6036390; rs6106668; rs6083041; rs13045070; rs6083018; rs8115487; rs16984996; rs6106653; rs6113984; rs6137972; rs8126371; rs6048613; rs2422760; rs6114121; rs7269048; rs2422756; rs2422774; rs6114027; rs6132618; rs6114062; rs6137891; rs6137902; rs2223859; rs6137911; rs6048862; rs6076037; rs6137956; rs6113939; rs2422757; rs6048878; rs6106640; rs6048570; rs2076648; rs2092379; rs2422769; rs6048684; rs2875760; rs6137965; rs6132619; rs11696420; rs13433241; rs6048868; rs6137904; rs6048768; rs11696423; rs4053457; rs6137912; rs6114075; rs11700354; rs6106604; rs4349401; rs6048796; rs6048752; rs6137852; rs6106683; rs6048870; rs2422755; rs8123084; rs6083054; rs6106625; rs6048563; rs6132624; rs6113955; rs2422759; rs7271300; rs9680019; rs6083001; rs9680025; rs6113932; rs2422752; rs12106280; rs11478666; rs12106116; rs13044306; rs11477545; rs11474621; rs10548828; rs11477942; rs2103758; rs34159462; rs6036327; rs34934730; rs6114052; rs6132635; rs10599806; rs11481317; rs6083144; rs7266902; rs6114056; rs35094578; rs3050737; rs34909737; rs6036331; rs28605071; rs8113916; rs35498299; rs6106620; rs35135829; rs13037449; rs34445977; rs6114057; rs6114162; rs9679998; rs6137862; rs6076077; rs11470465; rs6114076; rs34245773; rs7361683; rs6114114; rs13039571; rs34249296; rs2103759; rs6048567; rs11483293; rs6083019; rs6076054; rs6048758; rs35319898; rs11480817; rs7361473; rs11426342; rs6036427; rs28603365; rs34341795; rs1004268; rs35294593; rs6048861; rs35121359; rs6137888; rs6083143; rs17222895; rs35384370; rs33948150; rs12106237; rs6036314; rs34902644; rs35864458; rs11482107; rs6036389; rs36106878; rs6106671; rs34418464; rs6048902; rs33998426; rs34573803; rs11482900; rs6083068; rs34170813; rs35843804; rs7360200; rs34384547; rs6132637; rs10626077; rs6132638; rs7264522; rs11442124; rs33919468; rs34097585; rs6036329; rs11469865; rs10626299; rs6137868; rs34190162; rs3050743; rs2325846; rs6137879; rs6048565; rs34261789; rs35409492; rs6036467; rs34127349; rs33957203; rs34073977; rs36028144; rs34105580; rs35732086; rs6114081; rs6048881; rs36055977; rs6048675; rs6036312; rs34084659; rs11469794; rs3050735; rs6036431; rs4632428; rs12106117; rs13045947; rs6083034; rs34972666; rs6114002; rs41301752; rs6083028; rs3050731; rs34739156; rs34572886; rs36209483; rs34262420; rs34077962; rs1003488; rs13037404; rs11468734; rs6113940; rs4473460; rs11468806; rs33943065; rs35260408; rs6048865; rs6138002; rs6048588; rs34074229; rs11481911; rs9789801; rs34941654; rs11482757; rs36006705; rs9917440; rs28429255; rs41301754; rs34282039; rs28475778; rs34636509; rs13041071; rs35174834; rs10677058; rs6113934; rs28505454; rs3925862; rs1008405; rs1040485; rs1040486; rs1040487; rs12624537; rs13043849; rs13045386; rs1474680; rs16984515; rs17315896; rs2143246; rs2325850; rs2422733; rs2422734; rs2422735; rs2422739; rs2422740; rs2422741; rs2422742; rs2422751; rs4813474; rs4813475; rs4813507; rs4815171; rs4815227; rs6036285; rs6036286; rs6036288; rs6036289; rs6036290; rs6048503; rs6048507; rs6048508; rs6048509; rs6048510; rs6048521; rs6048528; rs6048961; rs6048966; rs6048968; rs6048970; rs6076015; rs6082968; rs6082976; rs6082996; rs6083228; rs6114219; rs6114223; rs6132559; rs6132649; rs6138035; rs6138041; rs726600; rs7274316; rs763996; rs8118007; rs956328; rs991187; rs991189

# Metabolic_Enzyme_44_General_References:
11780052

# Metabolic_Enzyme_44_References:
Not Available

# Metabolic_Enzyme_45_ID:
5965

# Metabolic_Enzyme_45_Name:
Glutaminyl-peptide cyclotransferase precursor

# Metabolic_Enzyme_45_Synonyms:
QC; Glutaminyl-tRNA cyclotransferase; Glutaminyl cyclase

# Metabolic_Enzyme_45_Gene_Name:
QPCT

# Metabolic_Enzyme_45_Protein_Sequence:
>Glutaminylpeptide cyclotransferase precursor
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L

# Metabolic_Enzyme_45_Number_of_Residues:
361

# Metabolic_Enzyme_45_Molecular_Weight:
40877

# Metabolic_Enzyme_45_Theoretical_pI:
6.60

# Metabolic_Enzyme_45_GO_Classification:
>>>
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_45_General_Function:
Not Available

# Metabolic_Enzyme_45_Specific_Function:
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue

# Metabolic_Enzyme_45_Pathway:
Not Available

# Metabolic_Enzyme_45_Reaction:
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3

# Metabolic_Enzyme_45_Pfam_Domain_Function:
PF04389:Peptidase_M28

# Metabolic_Enzyme_45_Signals:
1-28

# Metabolic_Enzyme_45_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_45_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_45_EC_Link:
EC 2.3.2.5

# Metabolic_Enzyme_45_GenBank_ID_Protein:
296949

# Metabolic_Enzyme_45_SwissProt_ID:
QPCT_HUMAN (Q16769)

# Metabolic_Enzyme_45_swissprot_Name:
Not Available

# Metabolic_Enzyme_45_Genecard_id:
QPCT

# Metabolic_Enzyme_45_Geneatlas_id:
QPCT

# Metabolic_Enzyme_45_hgnc_id:
HGNC:9753

# Metabolic_Enzyme_45_PDB_ID:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_45_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_45_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_45_Gene_Sequence:
>1086 bp
ATGGCAGGCGGAAGACACCGGCGCGTCGTGGGCACCCTCCACCTGCTGCTGCTGGTGGCC
GCCCTGCCCTGGGCATCCAGGGGGGTCAGTCCGAGTGCCTCAGCCTGGCCAGAGGAGAAG
AATTACCACCAGCCAGCCATTTTGAATTCATCGGCTCTTCGGCAAATTGCAGAAGGCACC
AGTATCTCTGAAATGTGGCAAAATGACTTACAGCCATTGCTGATAGAGCGATACCCGGGA
TCCCCTGGAAGCTATGCTGCTCGTCAGCACATCATGCAGCGAATTCAGAGGCTTCAGGCT
GACTGGGTCTTGGAAATAGACACCTTCTTGAGTCAGACACCCTATGGGTACCGGTCTTTC
TCAAATATCATCAGCACCCTCAATCCCACTGCTAAACGACATTTGGTCCTCGCCTGCCAC
TATGACTCCAAGTATTTTTCCCACTGGAACAACAGAGTGTTTGTAGGAGCCACTGATTCA
GCCGTGCCATGTGCAATGATGTTGGAACTTGCTCGTGCCTTAGACAAGAAACTCCTTTCC
TTAAAGACTGTTTCAGACTCCAAGCCAGATTTGTCACTCCAGCTGATCTTCTTTGATGGT
GAAGAGGCTTTTCTTCACTGGTCTCCTCAAGATTCTCTCTATGGGTCTCGACACTTAGCT
GCAAAGATGGCATCGACCCCGCACCCACCTGGAGCGAGAGGCACCAGCCAACTGCATGGC
ATGGATTTATTGGTCTTATTGGATTTGATTGGAGCTCCAAACCCAACGTTTCCCAATTTT
TTTCCAAACTCAGCCAGGTGGTTCGAAAGACTTCAAGCAATTGAACATGAACTTCATGAA
TTGGGTTTGCTCAAGGATCACTCTTTGGAGGGGCGGTATTTCCAGAATTACAGTTATGGA
GGTGTGATTCAGGATGACCATATTCCATTTTTAAGAAGAGGTGTTCCAGTTCTGCATCTG
ATACCGTCTCCTTTCCCTGAAGTCTGGCACACCATGGATGACAATGAAGAAAATTTGGAT
GAATCAACCATTGACAATCTAAACAAAATCCTACAAGTCTTTGTGTTGGAATATCTTCAT
TTGTAA

# Metabolic_Enzyme_45_GenBank_ID_Gene:
X71125

# Metabolic_Enzyme_45_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_45_Locus:
2p22.2

# Metabolic_Enzyme_45_SNPs:
rs2255991; rs2302652; rs6708310; rs10724; rs4670697; rs2373001; rs2058718; rs2302651; rs6730342; rs4670196; rs7603787; rs3815555; rs4384764; rs3770751; rs1468816; rs10198567; rs3770749; rs3770747; rs2270331; rs3770744; rs2287094; rs2058719; rs2373000; rs3770752; rs3770748; rs5017961; rs3770743; rs7564929; rs3770745; rs11897920; rs7606760; rs3770755; rs17020575; rs10196818; rs11897397; rs12467820; rs12472984; rs2888464; rs10490448; rs3821141; rs4444500; rs3770742; rs10865124; rs3770754; rs11689966; rs7576265; rs12468307; rs17020573; rs11886606; rs7582749; rs3770753; rs7600995; rs7606958; rs2372999; rs3821142; rs11890834; rs11903018; rs11891757; rs3770756; rs6756313; rs6544068; rs6544071; rs6753973; rs3755192; rs10170761; rs6544069; rs6544070; rs28384455; rs7601156; rs11555863; rs4670696; rs34476437; rs35184928; rs11555864; rs11555868; rs11555866; rs11555867; rs10683912; rs6706962; rs5830468; rs5830472; rs34891857; rs34156721; rs28609229; rs34908408; rs5830470; rs6721456; rs4670692; rs5017958; rs34281820; rs11124580; rs11402827; rs35157042; rs34534488; rs7596533; rs35426724; rs5830469; rs35661618; rs34300100; rs33911187; rs2372998; rs13015398; rs6708524; rs5017957; rs13404955; rs4479412; rs34463193; rs10203892; rs6722596; rs35276025; rs5830471; rs10179447; rs5017959; rs34773159; rs4670693; rs6708822; rs33960638; rs41280633; rs7603448; rs13015242; rs35921229; rs3770750; rs5017960; rs10558124; rs34763736; rs36087946; rs11902200; rs35537217; rs28590119; rs34679162; rs34524888; rs34231434; rs10598967; rs11124581; rs10185381; rs5830467; rs7584351; rs10189564; rs4479411; rs35576045; rs7587371; rs6732590; rs6761908; rs3755191; rs10084460; rs1024815; rs1024816; rs10490446; rs10490447; rs1105965; rs1105966; rs11886889; rs13030789; rs13417425; rs17020604; rs17020611; rs17020620; rs17020624; rs17020628; rs2041841; rs4233922; rs4425058; rs4670197; rs7559558; rs7570974; rs7585826; rs7593887; rs7593932; rs888096; rs952711; rs952712

# Metabolic_Enzyme_45_General_References:
7999256

# Metabolic_Enzyme_45_References:
Not Available

# Metabolic_Enzyme_46_ID:
5966

# Metabolic_Enzyme_46_Name:
Protein-glutamine gamma-glutamyltransferase Z

# Metabolic_Enzyme_46_Synonyms:
TGase Z; TGZ; TG(Z; Transglutaminase 7

# Metabolic_Enzyme_46_Gene_Name:
TGM7

# Metabolic_Enzyme_46_Protein_Sequence:
>Proteinglutamine gammaglutamyltransferase 
ZMDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHIT
FVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLK
IEISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITS
WPWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVL
QGNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRV
VSNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQV
LDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILA
HNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDL
LESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHG
GGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLV
LKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDL
GTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP

# Metabolic_Enzyme_46_Number_of_Residues:
710

# Metabolic_Enzyme_46_Molecular_Weight:
79942

# Metabolic_Enzyme_46_Theoretical_pI:
7.00

# Metabolic_Enzyme_46_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  biopolymer metabolism
Process:  biopolymer modification
Process:  protein modification
Process:  peptide cross-linking
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_46_General_Function:
Not Available

# Metabolic_Enzyme_46_Specific_Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

# Metabolic_Enzyme_46_Pathway:
Not Available

# Metabolic_Enzyme_46_Reaction:
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3

# Metabolic_Enzyme_46_Pfam_Domain_Function:
PF00927:Transglut_C;
PF01841:Transglut_core;
PF00868:Transglut_N

# Metabolic_Enzyme_46_Signals:
None

# Metabolic_Enzyme_46_Transmembrane_Regions:
None

# Metabolic_Enzyme_46_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_46_EC_Link:
EC 2.3.2.13

# Metabolic_Enzyme_46_GenBank_ID_Protein:
15425755

# Metabolic_Enzyme_46_SwissProt_ID:
TGM7_HUMAN (Q96PF1)

# Metabolic_Enzyme_46_swissprot_Name:
Not Available

# Metabolic_Enzyme_46_Genecard_id:
TGM7

# Metabolic_Enzyme_46_Geneatlas_id:
TGM7

# Metabolic_Enzyme_46_hgnc_id:
HGNC:30790

# Metabolic_Enzyme_46_PDB_ID:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_46_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_46_Subcellular_Location:
Not Available

# Metabolic_Enzyme_46_Gene_Sequence:
>2133 bp
ATGGATCAGGTGGCAACCTTGCGGCTTGAGTCTGTCGACCTGCAGAGCTCCAGGAACAAC
AAGGAGCACCACACGCAGGAGATGGGCGTCAAGCGGCTCACTGTGCGCCGCGGCCAGCCC
TTCTACCTCCGGCTGAGCTTCAGCCGACCCTTCCAGTCCCAGAACGACCACATCACCTTT
GTGGCTGAGACCGGACCCAAGCCGTCAGAGCTGCTGGGGACCCGAGCCACATTCTTCCTC
ACCCGGGTCCAGCCCGGGAATGTCTGGAGCGCTTCTGATTTCACCATTGACTCCAACTCT
CTCCAAGTTTCCCTTTTCACACCAGCCAATGCAGTTATTGGCCATTACACTCTGAAAATA
GAGATCTCTCAGGGCCAAGGTCACAGTGTGACTTACCCGCTGGGAACTTTCATCCTACTT
TTTAACCCTTGGAGTCCAGAGGACGACGTCTACCTGCCAAGTGAAATACTGCTGCAGGAG
TATATCATGCGAGATTATGGCTTTGTTTACAAGGGTCATGAAAGATTCATCACCTCCTGG
CCCTGGAACTACGGGCAGTTTGAAGAGGACATCATAGACATCTGCTTTGAGATCCTGAAC
AAGAGCCTGTATCACTTAAAGAACCCGGCCAAAGACTGTTCCCAGCGGAACGACGTGGTG
TATGTGTGCAGGGTGGTGAGTGCCATGATCAACAGCAACGATGACAATGGCGTGCTGCAG
GGGAACTGGGGCGAGGACTACTCCAAAGGGGTCAGTCCTCTGGAGTGGAAGGGCAGTGTG
GCCATCCTACAGCAGTGGTCAGCCAGGGGCGGGCAGCCTGTGAAGTACGGACAGTGCTGG
GTCTTCGCCTCTGTTATGTGCACCGTAATGAGATGCTTAGGTGTTCCAACCCGTGTTGTT
TCCAATTTCCGTTCCGCGCACAACGTGGATAGGAACTTGACCATCGATACGTACTATGAC
CGAAATGCCGAGATGCTGTCAACTCAGAAACGAGACAAAATATGGAACTTCCACGTCTGG
AATGAGTGCTGGATGATCCGGAAAGATCTCCCACCAGGATACAACGGGTGGCAGGTTCTG
GACCCCACTCCCCAGCAGACCAGCAGTGGGCTGTTCTGCTGTGGCCCTGCCTCTGTGAAG
GCCATCAGGGAAGGGGATGTCCACCTGGCCTATGACACCCCTTTTGTGTATGCCGAGGTG
AACGCCGATGAAGTCATTTGGCTCCTTGGGGATGGCCAGGCCCAGGAAATCCTGGCCCAC
AACACCAGTTCCATCGGGAAGGAGATCAGCACTAAGATGGTGGGGTCAGACCAGCGCCAG
AGCATCACCAGCTCCTACAAGTACCCAGAAGGATCCCCTGAGGAGAGAGCTGTCTTCATG
AAGGCTTCTCGGAAAATGCTGGGCCCCCAAAGAGCTTCTTTGCCCTTCCTGGATCTCCTG
GAGTCTGGGGGTCTTAGGGATCAGCCAGCGCAGCTGCAGCTTCACCTGGCCAGGATACCC
GAGTGGGGCCAGGACCTGCAGCTGCTGCTGCGTATCCAGAGGGTGCCAGACAGCACCCAC
CCTCGGGGGCCCATCGGACTGGTGGTGCGCTTCTGTGCACAGGCCCTGCTGCATGGGGGT
GGTACCCAGAAGCCCTTCTGGAGGCACACAGTGCGGATGAACCTGGACTTTGGGAAGGAG
ACACAGTGGCCGCTCCTCCTGCCCTACAGCAATTACAGAAACAAGCTAACGGACGAAAAG
CTCATCCGCGTGTCTGGCATCGCGGAGGTTGAAGAGACAGGGAGGTCCATGCTGGTCCTA
AAAGATATCTGTCTGGAGCCTCCCCACTTGTCTATTGAGGTGTCTGAGAGGGCTGAGGTG
GGCAAGGCGCTGAGAGTCCATGTCACCCTCACCAACACCTTAATGGTGGCTCTGAGCAGC
TGCACGATGGTGCTGGAAGGAAGCGGCCTCATCAATGGGCAGATAGCAAAGGACCTTGGG
ACTCTGGTGGCCGGACACACCCTCCAAATTCAACTGGACCTCTACCCGACCAAAGCTGGA
CCCCGCCAGCTCCAGGTTCTCATCAGCAGCAACGAGGTCAAGGAGATCAAAGGCTACAAG
GACATATTCGTCACTGTGGCTGGGGCTCCCTGA

# Metabolic_Enzyme_46_GenBank_ID_Gene:
AF363393

# Metabolic_Enzyme_46_Chromosome_Location:
Chromosome:15

# Metabolic_Enzyme_46_Locus:
15q15.2

# Metabolic_Enzyme_46_SNPs:
rs567357; rs513970; rs35228126; rs6493080; rs1108462; rs580469; rs825734; rs518261; rs489509; rs532672; rs556851; rs825740; rs825739; rs17779494; rs505276; rs485148; rs575304; rs825732; rs2412777; rs546722; rs491648; rs523737; rs518234; rs538238; rs498227; rs1896173; rs530683; rs491800; rs825733; rs8033666; rs12591919; rs8036632; rs12148735; rs478104; rs473554; rs1095389; rs4923962; rs7496049; rs558010; rs519926; rs35879868; rs35079211; rs34351037; rs7168979; rs34113528; rs519923; rs11335371; rs10697502; rs10654403; rs28448560; rs7171080; rs36122718; rs35603531; rs34502725; rs28673179; rs12909323; rs28496779; rs35571834; rs35782967; rs7171875; rs34776386; rs35891068; rs28446815; rs7169610; rs10668842; rs34487818; rs35430153; rs35119966; rs35387654; rs1095387; rs4923963; rs12901317; rs35005663; rs28641964; rs28525078; rs28594657; rs28600080; rs3038034; rs10661291; rs11637381; rs35124769; rs35863449; rs34647408; rs4923961; rs12185126; rs7173031; rs7180111; rs34927191; rs35220314; rs35393230; rs12915538; rs2277527; rs2577057; rs28377745; rs3759788; rs471122; rs473016; rs491804; rs492743; rs493444; rs505249; rs524527; rs526450; rs531910; rs573774; rs576557; rs748404

# Metabolic_Enzyme_46_General_References:
11390390

# Metabolic_Enzyme_46_References:
Not Available

# Metabolic_Enzyme_47_ID:
5967

# Metabolic_Enzyme_47_Name:
Glutamate dehydrogenase 1, mitochondrial precursor

# Metabolic_Enzyme_47_Synonyms:
GDH

# Metabolic_Enzyme_47_Gene_Name:
GLUD1

# Metabolic_Enzyme_47_Protein_Sequence:
>Glutamate dehydrogenase 1, mitochondrial precursor
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFKVYNEAGVTFT

# Metabolic_Enzyme_47_Number_of_Residues:
558

# Metabolic_Enzyme_47_Molecular_Weight:
61399

# Metabolic_Enzyme_47_Theoretical_pI:
7.91

# Metabolic_Enzyme_47_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  amino acid and derivative metabolism
Process:  amino acid metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_47_General_Function:
Replication, recombination and repair 

# Metabolic_Enzyme_47_Specific_Function:
May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate

# Metabolic_Enzyme_47_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00251  Glutamate metabolism;
 map00330  Arginine and proline metabolism;
 map00471  D-Glutamine and D-glutamate metabolism;
 map00910  Nitrogen metabolism

# Metabolic_Enzyme_47_Reaction:
L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + ammonia + NAD(P)H + H+

# Metabolic_Enzyme_47_Pfam_Domain_Function:
PF00208:ELFV_dehydrog;
PF02812:ELFV_dehydrog_N

# Metabolic_Enzyme_47_Signals:
1-20

# Metabolic_Enzyme_47_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_47_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_47_EC_Link:
EC 1.4.1.3

# Metabolic_Enzyme_47_GenBank_ID_Protein:
31707

# Metabolic_Enzyme_47_SwissProt_ID:
DHE3_HUMAN (P00367)

# Metabolic_Enzyme_47_swissprot_Name:
Not Available

# Metabolic_Enzyme_47_Genecard_id:
GLUD1

# Metabolic_Enzyme_47_Geneatlas_id:
GLUD1

# Metabolic_Enzyme_47_hgnc_id:
HGNC:4335

# Metabolic_Enzyme_47_PDB_ID:
1L1F

# Metabolic_Enzyme_47_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_47_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_47_Subcellular_Location:
Mitochondrion; mitochondrial matrix

# Metabolic_Enzyme_47_Gene_Sequence:
>1677 bp
ATGTACCGCTACCTGGGCGAAGCGCTGTTGCTGTCCCGGGCCGGGCCCGCTGCCCTGGGC
TCGGCGTCCGCCGACTCGGCCGCGTTGCTGGGCTGGGCCCGGGGACAGCCCGCCGCCGCC
CCGCAGCCGGGGCTGGCATTGGCCGCCCGGCGCCACTACAGCGAGGCGGTGGCCGACCGC
GAGGACGACCCCAACTTCTTCAAGATGGTGGAGGGCTTCTTCGATCGCGGCGCCAGCATC
GTGGAGGACAAGCTGGTGGAGGACCTGAGGACCCGGGAGAGCGAGGAGCAGAAGCGGAAC
CGGGTGCGCGGCATCCTGCGGATCATCAAGCCCTGCAACCATGTGCTGAGTCTCTCCTTC
CCCATCCGGCGCGACGACGGCTCCTGGGAGGTCATCGAAGGCTACCGGGCCCAGCACAGC
CAGCACCGCACGCCCTGCAAGGGAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA
GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGG
GGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGAACTATACTGATAATGAATTGGAAAAG
ATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGAT
GTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTAT
GCCAGCACCATAGGGCACTATGATATTAATGCACACGCCTGTGTTACTGGTAAACCCATC
AGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT
GAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGA
GATAAAACATTTGTTGTTCAGGGATTTGGTAATGTGGGCCTACACTCTATGAGATATTTA
CATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA
GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGC
TTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCTTGGAGGCCGACTGTGACATACTGATC
CCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC
ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGA
AACATTATGGTTATTCCAGATCTCTACTTGAATGCTGGAGGAGTGACAGTATCTTACTTT
GAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG
GATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAG
CATGGTGGAACTATTCCCATTGTACCCACGGCAGAGTTCCAAGACAGGATATCGGGTGCA
TCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA
ATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTT
AATGCCATTGAGAAAGTCTTCAAAGTGTACAATGAAGCTGGTGTGACCTTCACATAG

# Metabolic_Enzyme_47_GenBank_ID_Gene:
X07674

# Metabolic_Enzyme_47_Chromosome_Location:
Chromosome:10

# Metabolic_Enzyme_47_Locus:
10q23.3

# Metabolic_Enzyme_47_SNPs:
rs2181522; rs1923939; rs2296061; rs7083075; rs6586053; rs9420432; rs2296063; rs7903935; rs7069764; rs12416157; rs7098123; rs4934292; rs7068848; rs9421580; rs7077790; rs9421571; rs10887689; rs17107329; rs9421579; rs9420431; rs4933427; rs9421573; rs7072835; rs2146720; rs7080134; rs4934294; rs4460731; rs12414004; rs12778953; rs7076542; rs9421574; rs17107324; rs17343630; rs4275529; rs10887688; rs7090928; rs11202313; rs4460730; rs6586054; rs1923933; rs7076857; rs11202328; rs7895873; rs9420434; rs4491135; rs4934295; rs12257719; rs10887690; rs7085236; rs11202311; rs17343324; rs745224; rs1050340; rs1050359; rs1050306; rs1050319; rs11548293; rs3190657; rs12980; rs1803640; rs9420433; rs11202315; rs3204151; rs33966755; rs11453443; rs11202318; rs7096113; rs9421575; rs9421578; rs34096944; rs34237834; rs41448647; rs34610047; rs4933426; rs11306284; rs7903094; rs11202326; rs34760005; rs4370842; rs9732169; rs12781507; rs35027759; rs11202314; rs5786757; rs12761256; rs28590183; rs3204153; rs1923935; rs1923934; rs11202321; rs7075538; rs11202316; rs5786756; rs7478413; rs7911871; rs4934293; rs10544932; rs28581586; rs11202327; rs35275424; rs9421577; rs11202320; rs12416344; rs34141032; rs36124172; rs7067639; rs10565916; rs11202323; rs12763774; rs7069518; rs11202319; rs7083943; rs11202324; rs9421576; rs1923937; rs9421581; rs4244974; rs35186250; rs12256112; rs7089351; rs34165463; rs9420430; rs11272037; rs1923936; rs11202322; rs28621802; rs12778122; rs4934296; rs12256919; rs9651489; rs3204150; rs36079084; rs10909633; rs12266578; rs10655872; rs12763347; rs10535860; rs11202317; rs7096107; rs11345875; rs7923785; rs35002136; rs34156521; rs11202325; rs35811908; rs11431413; rs1923938; rs35075180; rs11428350; rs34933272; rs5786753; rs9421569; rs9420429; rs35924180; rs34324523; rs34307641; rs34369587; rs1050156; rs11202310; rs12251095; rs2296062; rs4430417

# Metabolic_Enzyme_47_General_References:
3426581; 3377777; 3399399; 3368458; 8486350; 429360; 1286669; 3585334; 8314555; 11254391; 11903050; 12054821; 12653548; 10338089; 9571255; 10636977; 11214910; 11297618

# Metabolic_Enzyme_47_References:
Not Available

# Metabolic_Enzyme_48_ID:
5968

# Metabolic_Enzyme_48_Name:
Glyceraldehyde-3-phosphate dehydrogenase

# Metabolic_Enzyme_48_Synonyms:
GAPDH

# Metabolic_Enzyme_48_Gene_Name:
GAPDH

# Metabolic_Enzyme_48_Protein_Sequence:
>Glyceraldehyde3phosphate dehydrogenase
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE

# Metabolic_Enzyme_48_Number_of_Residues:
335

# Metabolic_Enzyme_48_Molecular_Weight:
36054

# Metabolic_Enzyme_48_Theoretical_pI:
8.73

# Metabolic_Enzyme_48_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors
Function:  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Function:  glyceraldehyde-3-phosphate dehydrogenase activity
Function:  glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  alcohol metabolism
Process:  monosaccharide metabolism
Process:  hexose metabolism
Process:  glucose metabolism
Process:  glucose catabolism
Process:  glycolysis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_48_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_48_Specific_Function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

# Metabolic_Enzyme_48_Pathway:
map00010  Glycolysis / Gluconeogenesis

# Metabolic_Enzyme_48_Reaction:
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+

# Metabolic_Enzyme_48_Pfam_Domain_Function:
PF02800:Gp_dh_C;
PF00044:Gp_dh_N

# Metabolic_Enzyme_48_Signals:
None

# Metabolic_Enzyme_48_Transmembrane_Regions:
None

# Metabolic_Enzyme_48_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_48_EC_Link:
EC 1.2.1.12

# Metabolic_Enzyme_48_GenBank_ID_Protein:
31645

# Metabolic_Enzyme_48_SwissProt_ID:
G3P_HUMAN (P04406)

# Metabolic_Enzyme_48_swissprot_Name:
Not Available

# Metabolic_Enzyme_48_Genecard_id:
GAPDH

# Metabolic_Enzyme_48_Geneatlas_id:
GAPDH

# Metabolic_Enzyme_48_hgnc_id:
HGNC:4141

# Metabolic_Enzyme_48_PDB_ID:
1J0X

# Metabolic_Enzyme_48_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_48_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_48_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_48_Gene_Sequence:
>1008 bp
ATGGGGAAGGTGAAGGTCGGAGTCAACGGATTTGGTCGTATTGGGCGCCTGGTCACCAGG
GCTGCTTTTAACTCTGGTAAAGTGGATATTGTTGCCATCAATGACCCCTTCATTGACCTC
AACTACATGGTTTACATGTTCCAATATGATTCCACCCATGGCAAATTCCATGGCACCGTC
AAGGCTGAGAACGGGAAGCTTGTCATCAATGGAAATCCCATCACCATCTTCCAGGAGCGA
GATCCCTCCAAAATCAAGTGGGGCGATGCTGGCGCTGAGTACGTCGTGGAGTCCACTGGC
GTCTTCACCACCATGGAGAAGGCTGGGGCTCATTTGCAGGGGGGAGCCAAAAGGGTCATC
ATCTCTGCCCCCTCTGCTGATGCCCCCATGTTCGTCATGGGTGTGAACCATGAGAAGTAT
GACAACAGCCTCAAGATCATCAGCAATGCCTCCTGCACCACCAACTGCTTAGCACCCCTG
GCCAAGGTCATCCATGACAACTTTGGTATCGTGGAAGGACTCATGACCACAGTCCATGCC
ATCACTGCCACCCAGAAGACTGTGGATGGCCCCTCCGGGAAACTGTGGCGTGATGGCCGC
GGGGCTCTCCAGAACATCATCCCTGCCTCTACTGGCGCTGCCAAGGCTGTGGGCAAGGTC
ATCCCTGAGCTAGACGGGAAGCTCACTGGCATGGCCTTCCGTGTCCCCACTGCCAACGTG
TCAGTGGTGGACCTGACCTGCCGTCTAGAAAAACCTGCCAAATATGATGACATCAAGAAG
GTGGTGAAGCAGGCGTCGGAGGGCCCCCTCAAAGGCATCCTGGGCTACACTGAGCACCAG
GTGGTCTCCTCTGACTTCAACAGCGACACCCACTCCTCCACCTTTGACGCTGGGGCTGGC
ATTGCCCTCAACGACCACTTTGTCAAGCTCATTTCCTGGTATGACAACGAATTTGGCTAC
AGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAA

# Metabolic_Enzyme_48_GenBank_ID_Gene:
X01677

# Metabolic_Enzyme_48_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_48_Locus:
12p13

# Metabolic_Enzyme_48_SNPs:
rs1803621; rs1065691; rs1803622; rs1136666; rs3741918; rs3741917; rs1060619; rs1060620; rs1060621; rs2886093; rs41334949; rs7971637; rs6489721; rs11549346; rs11549333; rs11549340; rs1065740; rs11549329; rs11549351; rs11549345; rs1062442; rs3211600; rs1803625; rs1062429; rs1062436; rs11549361; rs11549327; rs11549316; rs11549338; rs11549348; rs11549373; rs11549343; rs11549336; rs11549325; rs11549350; rs11549371; rs11549355; rs3203507; rs11549347; rs11266742; rs11549318; rs3211592; rs11549319; rs3199979; rs11549332; rs3741915; rs11549320; rs3211599; rs3211598; rs11552253; rs35318117; rs35043201; rs3759342; rs36015908; rs34277306; rs12425927; rs7307229; rs7977806; rs36094914; rs1043262; rs1047792; rs1063206; rs10849482; rs10849483; rs10849484; rs10849485; rs10849488; rs11064250; rs16932751; rs2072374; rs2240871; rs2240875; rs2270176; rs2270177; rs35819349; rs7132183; rs7297283; rs7300366; rs7311174; rs7316224; rs733593; rs740850; rs740851; rs740852; rs758740; rs7979706

# Metabolic_Enzyme_48_General_References:
6096136; 6096821; 2987855; 3664468; 3027061; 3170585; 1924305; 10944468; 7030790; 12665801; 7498159; 1193541; 957435

# Metabolic_Enzyme_48_References:
Not Available

# Metabolic_Enzyme_49_ID:
5438

# Metabolic_Enzyme_49_Name:
D-amino-acid oxidase

# Metabolic_Enzyme_49_Synonyms:
DAMOX; DAO; DAAO

# Metabolic_Enzyme_49_Gene_Name:
DAO

# Metabolic_Enzyme_49_Protein_Sequence:
>Daminoacid oxidase
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL

# Metabolic_Enzyme_49_Number_of_Residues:
347

# Metabolic_Enzyme_49_Molecular_Weight:
39475

# Metabolic_Enzyme_49_Theoretical_pI:
6.84

# Metabolic_Enzyme_49_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_49_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_49_Specific_Function:
Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids

# Metabolic_Enzyme_49_Pathway:
map00260  Glycine, serine and threonine metabolism;
 map00330  Arginine and proline metabolism;
 map00472  D-Arginine and D-ornithine metabolism

# Metabolic_Enzyme_49_Reaction:
a D-amino acid + H2O + O2 = a 2-oxo acid + ammonia + H2O2

# Metabolic_Enzyme_49_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_49_Signals:
1-16

# Metabolic_Enzyme_49_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_49_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_49_EC_Link:
EC 1.4.3.3

# Metabolic_Enzyme_49_GenBank_ID_Protein:
30446

# Metabolic_Enzyme_49_SwissProt_ID:
OXDA_HUMAN (P14920)

# Metabolic_Enzyme_49_swissprot_Name:
Not Available

# Metabolic_Enzyme_49_Genecard_id:
DAO

# Metabolic_Enzyme_49_Geneatlas_id:
DAO

# Metabolic_Enzyme_49_hgnc_id:
HGNC:2671

# Metabolic_Enzyme_49_PDB_ID:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_49_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_49_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_49_Gene_Sequence:
>1044 bp
ATGCGTGTGGTGGTGATTGGAGCAGGAGTCATCGGGCTGTCCACCGCCCTCTGCATCCAT
GAGCGCTACCACTCAGTCCTGCAGCCACTGCACATAAAGGTCTACGCGGACCGCTTCACC
CCACTCACCACCACCGACGTGGCTGCCGGCCTCTGGCAGCCCTACCTTTCTGACCCCAAC
AACCCACAGGAGGCGGACTGGAGCCAACAGACCTTTGACTATCTCCTGAGCCATGTCCAT
TCTCCCAACGCTGAAAACCTGGGCCTGTTCCTAATCTCGGGCTACAACCTCTTCCATGAA
GCCATTCCGGACCCTTCCTGGAAGGACACAGTTCTGGGATTTCGGAAGCTGACCCCCAGA
GAGCTGGATATGTTCCCAGATTACGGCTATGGCTGGTTCCACACAAGCCTAATTCTGGAG
GGAAAGAACTATCTACAGTGGCTGACTGAAAGGTTAACTGAGAGGGGAGTGAAGTTCTTC
CAGCGGAAAGTGGAGTCTTTTGAGGAGGTGGCAAGAGAAGGCGCAGACGTGATTGTCAAC
TGCACTGGGGTATGGGCTGGGGCGCTACAACGAGACCCCCTGCTGCAGCCAGGCCGGGGG
CAGATCATGAAGGTGGACGCCCCTTGGATGAAGCACTTCATTCTCACCCATGACCCAGAG
AGAGGCATCTACAATTCCCCGTACATCATCCCAGGGACCCAGACAGTTACTCTTGGAGGC
ATCTTCCAGTTGGGAAACTGGAGTGAACTAAACAATATCCAGGACCACAACACCATTTGG
GAAGGCTGCTGCAGACTGGAGCCCACACTGAAGAATGCAAGAATTATTGGTGAAGCAACT
GGCTTCCGGCCAGTACGCCCCCAGATTCGGCTAGAAAGAGAACAGCTTCGCACTGGACCT
TCAAACACAGAGGTCATCCACAACTATGGCCATGGAGGCTACGGGCTCACCATCCACTGG
GGATGTGCCCTGGAGGCAGCCAAGCTCTTTGGGAGAATCCTGGAAGAAAAGAAATTGTCC
AGAATGCCACCATCCCACCTCTGA

# Metabolic_Enzyme_49_GenBank_ID_Gene:
X13227

# Metabolic_Enzyme_49_Chromosome_Location:
Chromosome:12

# Metabolic_Enzyme_49_Locus:
12q24

# Metabolic_Enzyme_49_SNPs:
rs7980427; rs2111902; rs7977762; rs4964767; rs17041020; rs12579920; rs4964766; rs2070588; rs11114083; rs9706062; rs2070586; rs4964765; rs7316889; rs2070585; rs2070587; rs1808351; rs11830725; rs3741775; rs11114086; rs11114085; rs6539458; rs3918347; rs6539460; rs10861974; rs4964281; rs11837302; rs3918346; rs7967441; rs11114084; rs11114087; rs12426462; rs6539459; rs6539462; rs2302882; rs3741774; rs4964280; rs17041050; rs17041074; rs9669254; rs3825251; rs12229954; rs6539461; rs17041058; rs7962665; rs17041040; rs7975723; rs10778658; rs3741776; rs17041039; rs7302245; rs4623951; rs10861973; rs7965821; rs35388422; rs4262766; rs35658778; rs4644682; rs35550859; rs34135554; rs11415772; rs762451; rs34780883; rs11417050; rs1053875; rs3741773; rs35481176; rs11611767; rs10689951; rs10696805; rs4989798; rs35363883; rs28868909; rs12810412; rs11301485; rs34552650; rs35324225; rs7134038; rs36013571; rs7967357; rs35521446; rs4989799; rs35572480; rs36104885; rs9668314; rs5800839; rs12811324; rs11420034; rs11335673; rs11464907; rs11402329; rs11356161; rs9668327; rs7138366; rs35258241; rs34666571; rs35167645; rs10599880; rs35681690; rs12810212; rs10778659; rs12830695; rs35356685; rs36032329; rs11114080; rs11114081; rs34178394; rs10861977; rs1129027; rs12308912; rs4964762; rs4964770; rs7294679; rs7308400; rs7958090

# Metabolic_Enzyme_49_General_References:
2901986; 1356107

# Metabolic_Enzyme_49_References:
Not Available

# Metabolic_Enzyme_50_ID:
5929

# Metabolic_Enzyme_50_Name:
AMP deaminase 1

# Metabolic_Enzyme_50_Synonyms:
Myoadenylate deaminase; AMP deaminase isoform M

# Metabolic_Enzyme_50_Gene_Name:
AMPD1

# Metabolic_Enzyme_50_Protein_Sequence:
>AMP deaminase 1
MPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFH
LETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQI
TGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESF
YPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTF
LDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKV
DTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSL
DVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQ
HAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLE
NIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPS
YTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKK
SPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEP
LMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNV
AQIRMAYRYETWCYELNLIAEGLKSTE

# Metabolic_Enzyme_50_Number_of_Residues:
747

# Metabolic_Enzyme_50_Molecular_Weight:
86491

# Metabolic_Enzyme_50_Theoretical_pI:
6.89

# Metabolic_Enzyme_50_GO_Classification:
>>>
Function:  hydrolase activity
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Function:  AMP deaminase activity
Function:  catalytic activity
Function:  deaminase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine nucleoside monophosphate biosynthesis
Process:  purine ribonucleoside monophosphate biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_50_General_Function:
Not Available

# Metabolic_Enzyme_50_Specific_Function:
AMP deaminase plays a critical role in energy metabolism

# Metabolic_Enzyme_50_Pathway:
map00230  Purine metabolism

# Metabolic_Enzyme_50_Reaction:
AMP + H2O = IMP + ammonia

# Metabolic_Enzyme_50_Pfam_Domain_Function:
PF00962:A_deaminase

# Metabolic_Enzyme_50_Signals:
None

# Metabolic_Enzyme_50_Transmembrane_Regions:
None

# Metabolic_Enzyme_50_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_50_EC_Link:
EC 3.5.4.6

# Metabolic_Enzyme_50_GenBank_ID_Protein:
10864686

# Metabolic_Enzyme_50_SwissProt_ID:
AMPD1_HUMAN (P23109)

# Metabolic_Enzyme_50_swissprot_Name:
Not Available

# Metabolic_Enzyme_50_Genecard_id:
AMPD1

# Metabolic_Enzyme_50_Geneatlas_id:
AMPD1

# Metabolic_Enzyme_50_hgnc_id:
HGNC:468

# Metabolic_Enzyme_50_PDB_ID:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_50_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_50_Subcellular_Location:
Cytoplasmic

# Metabolic_Enzyme_50_Gene_Sequence:
>2244 bp
ATGCCTCTGTTCAAACTCCCAGCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTT
GCTGAAAAAGTGTTTGCCTCTGAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCC
TTTGATGTGGATGAGATCTGTCCGATTTCTCATCATGAGATGCAAGCACACATATTCCAT
CTGGAGACTCTGTCCACCTCCACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAG
ACTGTTAATTTGTCCATTCCACTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGAT
GAATACATTTCCTCATCTCCAACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATT
ACTGGTGACTATGCCTCTGGGGTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTG
TATCGGGCACTATGCATACGTGAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAA
ACCCCTTCCAAATACTTGCGGAACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTC
TATCCAGTCTTTACTCCTCCTGTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTT
CCTGAAAACCTGGGCTATCACCTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAAT
GAAGCAGCAGTCAGCAAAGATGAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTC
TTAGACGATATGAATTTTTTACTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACC
CACCGGCGCCTGAAGTTCCTCTCCTCGAAGTTCCAGGTCCATCAGATGCTTAACGAGATG
GACGAGTTAAAGGAGCTGAAAAACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTG
GACACCCATATCCATGCAGCCGCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAG
AAATCTTACCAAATTGATGCTGACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACC
CTAAAGGAACTTTTTGCTAAATTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTG
GATGTTCATGCTGGACGCCAGACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAAT
CCTGTAGGAGCAAGTGAGCTACGGGACCTCTACTTGAAGACAGACAATTACATTAATGGG
GAATATTTTGCCACTATCATCAAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAG
CATGCTGAGCCCCGCCTGTCCATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCC
TCCTGGTTCGTCTGCAATCGCATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCC
AGGATCTATGATGTGTTCCGTTCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAG
AATATTTTCATGCCAGTGTTTGAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGT
GTCTTCCTCAAGCATATCACTGGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGC
CACATGTTCTCCTCCAAGAGTCCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCT
TACACTTACTATGCCTACTACATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAG
GAACGAGGCATGAATACGTTTCTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACC
CATCTCATGACAGCATTCATGATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAG
AGTCCCGTGCTACAGTACTTGTTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTA
AGTAACAATAGCCTATTTCTAGAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAA
GGGCTAATGATCTCACTGTCTACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCC
CTAATGGAAGAATATGCTATTGCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGC
GAAGTGGCAAGGAACAGTGTCTTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTT
CTGGGCGACAATTACCTTGAGGAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTA
GCCCAAATCCGCATGGCCTATCGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCT
GAGGGTCTTAAATCAACAGAATAA

# Metabolic_Enzyme_50_GenBank_ID_Gene:
M37931

# Metabolic_Enzyme_50_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_50_Locus:
1p13

# Metabolic_Enzyme_50_SNPs:
rs17602729; rs12566550; rs2268697; rs2010899; rs2268701; rs2336363; rs761755; rs2268700; rs2268699; rs2070986; rs743041; rs6679869; rs7531877; rs12407408; rs6683173; rs1884296; rs2268698; rs3789627; rs7515356; rs11585780; rs17032832; rs6678312; rs11102831; rs11589112; rs6697362; rs12132598; rs6663302; rs12038990; rs2268696; rs11588144; rs926938; rs6667218; rs34526199; rs35859650; rs2273268; rs34778674; rs34287100; rs949421; rs35197706; rs34257411; rs12096667; rs11451311; rs34245099; rs7518060; rs35468504; rs10698057; rs35746234; rs34418559; rs34741374; rs34355177; rs10601370; rs33984400; rs7541903; rs35241478; rs6656110; rs34630625; rs12036263; rs35985810; rs6685096; rs11412027; rs7543893; rs12354159; rs10645732; rs10611520; rs6701394; rs6701427; rs915955; rs737549; rs34909498; rs35027577; rs6697757; rs10776787; rs11577646; rs11587596; rs11799831; rs11801474; rs11803022; rs12564817; rs12753208; rs17032822; rs4537551; rs4839014; rs6537843; rs6695699; rs7516111

# Metabolic_Enzyme_50_General_References:
2345176; 1370861; 1631143; 11102975

# Metabolic_Enzyme_50_References:
Not Available

# Metabolic_Enzyme_51_ID:
5379

# Metabolic_Enzyme_51_Name:
D-aspartate oxidase

# Metabolic_Enzyme_51_Synonyms:
DASOX; DDO

# Metabolic_Enzyme_51_Gene_Name:
DDO

# Metabolic_Enzyme_51_Protein_Sequence:
>Daspartate oxidase
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL

# Metabolic_Enzyme_51_Number_of_Residues:
341

# Metabolic_Enzyme_51_Molecular_Weight:
37535

# Metabolic_Enzyme_51_Theoretical_pI:
7.99

# Metabolic_Enzyme_51_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  D-amino-acid oxidase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_51_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_51_Specific_Function:
Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate

# Metabolic_Enzyme_51_Pathway:
map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_51_Reaction:
D-aspartate + H2O + O2 = oxaloacetate + ammonia + H2O2

# Metabolic_Enzyme_51_Pfam_Domain_Function:
PF01266:DAO

# Metabolic_Enzyme_51_Signals:
1-19

# Metabolic_Enzyme_51_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_51_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_51_EC_Link:
EC 1.4.3.1

# Metabolic_Enzyme_51_GenBank_ID_Protein:
1742024

# Metabolic_Enzyme_51_SwissProt_ID:
OXDD_HUMAN (Q99489)

# Metabolic_Enzyme_51_swissprot_Name:
Not Available

# Metabolic_Enzyme_51_Genecard_id:
DDO

# Metabolic_Enzyme_51_Geneatlas_id:
DDO

# Metabolic_Enzyme_51_hgnc_id:
HGNC:2727

# Metabolic_Enzyme_51_PDB_ID:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_51_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_51_Subcellular_Location:
Peroxisome

# Metabolic_Enzyme_51_Gene_Sequence:
>1026 bp
ATGGACACAGCACGGATTGCAGTTGTCGGGGCAGGTGTGGTGGGGCTCTCCACGGCTGTG
TGCATCTCCAAACTGGTGCCCCGATGCTCCGTTACCATCATTTCAGACAAGTTTACTCCA
GATACCACCAGTGATGTGGCAGCCGGAATGCTTATTCCTCACACTTATCCAGATACACCC
ATTCACACGCAGAAGCAGTGGTTCAGAGAAACCTTTAATCACCTCTTTGCAATTGCCAAT
TCTGCAGAAGCTGGAGATGCTGGTGTTCATTTGGTATCAGGTTGGCAGATATTTCAGAGC
ACTCCGACTGAAGAAGTGCCATTCTGGGCTGACGTGGTTCTGGGATTTCGAAAGATGACT
GAGGCTGAGCTGAAGAAATTCCCCCAGTATGTGTTTGGTCAGGCTTTTACAACCCTGAAA
TGTGAATGCCCTGCCTACCTCCCGTGGTTGGAGAAAAGGATAAAGGGAAGTGGAGGCTGG
ACACTCACTCGGCGAATAGAAGACCTGTGGGAACTTCATCCGTCCTTTGACATCGTGGTC
AACTGTTCAGGCCTTGGAAGCAGACAGCTTGCAGGAGACTCAAAGATTTTCCCTGTAAGG
GGCCAAGTCCTCCAAGTTCAGGCTCCCTGGGTGGAGCATTTTATCCGAGATGGCAGTGGG
CTGACATATATTTATCCTGGTACATCCCATGTAACCCTAGGTGGAACTAGGCAAAAAGGG
GACTGGAATCTGTCCCCGGATGCAGAAAATAGCAGAGAGATTCTTTCCCGATGCTGTGCT
CTGGAGCCCTCCCTCCACGGAGCCTGCAACATCAGGGAGAAGGTGGGCTTGAGGCCCTAC
AGGCCAGGCGTGCGACTGCAGACAGAGCTCCTTGCGCGAGATGGACAGAGGCTGCCTGTA
GTCCACCACTATGGCCATGGGAGTGGGGGCATCTCAGTGCACTGGGGCACTGCTCTGGAG
GCCGCCAGGCTGGTGAGCGAGTGTGTCCATGCCCTCAGGACCCCCATTCCCAAGTCAAAC
CTGTAG

# Metabolic_Enzyme_51_GenBank_ID_Gene:
D89858

# Metabolic_Enzyme_51_Chromosome_Location:
Chromosome:6

# Metabolic_Enzyme_51_Locus:
6q21

# Metabolic_Enzyme_51_SNPs:
Not Available

# Metabolic_Enzyme_51_General_References:
9163533; 14574404

# Metabolic_Enzyme_51_References:
Not Available

# Metabolic_Enzyme_52_ID:
5969

# Metabolic_Enzyme_52_Name:
Protein-lysine 6-oxidase precursor

# Metabolic_Enzyme_52_Synonyms:
Lysyl oxidase

# Metabolic_Enzyme_52_Gene_Name:
LOX

# Metabolic_Enzyme_52_Protein_Sequence:
>Proteinlysine 6oxidase precursor
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY

# Metabolic_Enzyme_52_Number_of_Residues:
417

# Metabolic_Enzyme_52_Molecular_Weight:
46944

# Metabolic_Enzyme_52_Theoretical_pI:
8.14

# Metabolic_Enzyme_52_GO_Classification:
>>>
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  copper ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors
Function:  oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Function:  protein-lysine 6-oxidase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_52_General_Function:
Not Available

# Metabolic_Enzyme_52_Specific_Function:
Responsible for the posttranslational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression

# Metabolic_Enzyme_52_Pathway:
Not Available

# Metabolic_Enzyme_52_Reaction:
peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + ammonia + H2O2

# Metabolic_Enzyme_52_Pfam_Domain_Function:
PF01186:Lysyl_oxidase

# Metabolic_Enzyme_52_Signals:
1-21

# Metabolic_Enzyme_52_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_52_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_52_EC_Link:
EC 1.4.3.13

# Metabolic_Enzyme_52_GenBank_ID_Protein:
244146

# Metabolic_Enzyme_52_SwissProt_ID:
LYOX_HUMAN (P28300)

# Metabolic_Enzyme_52_swissprot_Name:
Not Available

# Metabolic_Enzyme_52_Genecard_id:
LOX

# Metabolic_Enzyme_52_Geneatlas_id:
LOX

# Metabolic_Enzyme_52_hgnc_id:
HGNC:6664

# Metabolic_Enzyme_52_PDB_ID:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_52_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_52_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_52_Gene_Sequence:
>1254 bp
ATGCGCTTCGCCTGGACCGTGCTCCTGCTCGGGCCTTTGCAGCTCTGCGCGCTAGTGCAC
TGCGCCCCTCCCGCCGCCGGCCAACAGCAGCCCCCGCGCGAGCCGCCGGCGGCTCCGGGC
GCCTGGCGCCAGCAGATCCAATGGGAGAACAACGGGCAGGTGTTCAGCTTGCTGAGCCTG
GGCTCACAGTACCAGCCTCAGCGCCGCCGGGACCCGGGCGCCGCCGTCCCTGGTGCAGCC
AACGCCTCCGCCCAGCAGCCCCGCACTCCGATCCTGCTGATCCGCGACAACCGCACCGCC
GCGGGGCGAACGCGGACGGCCGGCTCATCTGGAGTCACCGCTGGCCGCCCCAGGCCCACC
GCCCGTCACTGGTTCCAAGCTGGCTACTCGACATCTAGAGCCCGCGAAGCTGGGCCCTCG
CGCGCGGAGAACCAGACAGCGCCGGGAGAAGTTCCTGCTCTCAGTAACCTGCGGCCGCCC
AGCCGCGTGGACGGCATGGTGGGCGACGACCCTTACAACCCCTACAAGTACTCTGACGAC
AACCCTTATTACAACTACTACGATACTTATGAAAGGCCCAGACCTGGGGGCAGGTACCGG
CCCGGATACGGCACTGGCTACTTCCAGTACGGTCTCCCAGACCTGGTGGCCGACCCCTAC
TACATCCAGGCGTCCACGTACGTGCAGAAGATGTCCATGTACAACCTGAGATGCGCGGCG
GAGGAAAACTGTCTGGCCAGTACAGCATACAGGGCAGATGTCAGAGATTATGATCACAGG
GTGCTGCTCAGATTTCCCCAAAGAGTGAAAAACCAAGGGACATCAGATTTCTTACCCAGC
CGACCAAGATATTCCTGGGAATGGCACAGTTGTCATCAACATTACCACAGTATGGATGAG
TTTAGCCACTTGTACCTGCTTGATGCCAACACCCAGAGGAGATGGGCTGAAGGCCACAAA
GCAAGTTTCTGTCTTGAAGACACATCCTGTGACTATGGCTACCACAGGCGATTTGCATGT
ACTGCACACACACAGGGATTGAGTCCTGGCTGTTATGATACCTATGGTGCAGACATAGAC
TGCCAGTGGATTGATATTACAGATGTAAAACCTGGAAACTATATCCTAAAGGTCAGTGTA
AACCCCAGCTACCTGGTTCCTGAATCTGACTATACCAACAATGTTGTGCGCTGTGACATT
CGCTACACAGGACATCATGCGTATGCCTCAGGCTGCACAATTTCACCGTATTAG

# Metabolic_Enzyme_52_GenBank_ID_Gene:
S78694

# Metabolic_Enzyme_52_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_52_Locus:
5q23.2

# Metabolic_Enzyme_52_SNPs:
rs1800449; rs17352251; rs10053942; rs3792801; rs2956540; rs3792803; rs10040971; rs2288393; rs17148773; rs10519694; rs3805442; rs3792802; rs10059661; rs41296581; rs6879333; rs2303656; rs17148776; rs3805443; rs2979862; rs17148765; rs17148788; rs7711879; rs3763024; rs2914604; rs41407546; rs34226651; rs2434980; rs2434979; rs35146783; rs2278226; rs2956539; rs34428738; rs2979868; rs2956537; rs41478244; rs3835066; rs2979865; rs34043142; rs17352491; rs6897004; rs2979870; rs2914603; rs2979863; rs2914600; rs2979869; rs10650287; rs2914599; rs34480003; rs2979867; rs35356762; rs3805444; rs2914602; rs41407947; rs2913396; rs2979866; rs2914601; rs36044767; rs41529549; rs2979864; rs6863233; rs35544795; rs10058077; rs41485947; rs11547203; rs34478531; rs3834824; rs2913397; rs840467; rs2913399; rs840466; rs7447408; rs34696124; rs41367345; rs2913398; rs10519692; rs10519693; rs11956933; rs13173506; rs13184805; rs17352083; rs17352097; rs17352686; rs17431081; rs2731646; rs2731647; rs2913400; rs2913401; rs2913402; rs2913403; rs2913405; rs2913406; rs2913407; rs2914611; rs2956538; rs2979860; rs2979872; rs3853401; rs840460; rs840461; rs840462; rs840464; rs864548; rs995687; rs995688; rs995689

# Metabolic_Enzyme_52_General_References:
1685472; 1357535; 10391127; 7902322; 1352776; 9111998; 8100215

# Metabolic_Enzyme_52_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7556

# Macromolecular_Interacting_Partner_1_Name:
Serum albumin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Name:
ALB

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Serum albumin precursor
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
609

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
69367

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
6.21

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  transporter activity
Function:  carrier activity
 ||
>>>
Process:  physiological process
Process:  cellular physiological process
Process:  transport
 ||
>>>
Component:  extracellular region
Component:  extracellular space

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00273:Serum_albumin

# Macromolecular_Interacting_Partner_1_Signals:
1-18

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
28590

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
ALBU_HUMAN (P02768)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
ALB

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
ALB

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:399

# Macromolecular_Interacting_Partner_1_PDB_ID:
1HA2

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
V00494

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:4

# Macromolecular_Interacting_Partner_1_Locus:
4q11-q13

# Macromolecular_Interacting_Partner_1_SNPs:
rs1063469; rs962004; rs1475934; rs2051512; rs4621399; rs962005; rs6832260; rs2236767; rs3926327; rs2236766; rs7678298; rs3775486; rs10022167; rs16849331; rs3775485; rs4076; rs7670052; rs6810745; rs16849341; rs9999209; rs16849334; rs13114289; rs2051510; rs7670092; rs9631551; rs3756066; rs7688274; rs4429703; rs13138260; rs3756067; rs11538227; rs11538209; rs3210154; rs11538226; rs11538223; rs11538214; rs3204504; rs11538213; rs11538221; rs11538217; rs11538228; rs11538222; rs3210163; rs11538208; rs11538220; rs1140449; rs17400586; rs35683929; rs17853250; rs11538230; rs17853503; rs17854154; rs11538206; rs11538224; rs11538231; rs11538212; rs11538229; rs17854155; rs1140450; rs11538225; rs17853494; rs1800580; rs35283985; rs11538207; rs3211553; rs3205432; rs34282137; rs11538205; rs11538204; rs11427330; rs10002897; rs35905299; rs35782353; rs34513283; rs11436422; rs34052046; rs16849344; rs11937538; rs17855587; rs11351486; rs667; rs34563172; rs9999941; rs34313532; rs41494947; rs35807836; rs2051511; rs35985573; rs34387837; rs13122292; rs35065157; rs36067576; rs10027725; rs12649712; rs16849364; rs16849366; rs16849372; rs34686165; rs35335733; rs36110527; rs4270557; rs4498110; rs4513532; rs4575963; rs4602472; rs4694613; rs4694614; rs6446931; rs6829532; rs9784582; rs9996318

# Macromolecular_Interacting_Partner_1_General_References:
6171778; 6275391; 3009475; 11483580; 12975309; 2419329; 1225573; 7895732; 12665801; 3087352; 2437111; 955075; 656055; 2727704; 2374930; 1630489; 9731778; 10388840; 10940303; 11743713; 3828358; 3474609; 3479777; 2911589; 2762316; 2404284; 2104980; 2247440; 2068071; 1946412; 1859851; 1347703; 1518850; 8513793; 8347685; 7902134; 8022807; 8048949; 7852505; 9329347; 9589637; 11680902; 11168369

# Macromolecular_Interacting_Partner_1_References:
16094515; 16454356; 16962796

End of HMDB00051

Beginning of HMDB00052
# Accession_No:
HMDB00052

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2006-10-25 15:46:40

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Argininosuccinic acid

# Description:
Arginosuccinic acid is a chemical compound that belongs to the class of the amino acids. Some cells synthesize it from citrulline, aspartic acid and use it as a precursor for arginine in the urea cycle or Citrulline-NO cycle.

# Synonyms:
Argininosuccinate; Argininosuccinic acid; Arginosuccinate; Arginosuccinic acid; L-Argininosuccinate; L-Argininosuccinic acid; L-Arginosuccinate; L-Arginosuccinic acid; N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartate; N-(((4-amino-4-carboxybutyl)amino)iminomethyl)-L-Aspartic acid; N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartate; N-[(4-amino-4-carboxybutyl)amidino]-L-Aspartic acid; N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartate; N-[[(4-amino-4-carboxybutyl)amino]iminomethyl]-L-Aspartic acid

# Chemical_IUPAC_Name:
2-[amino-(4-amino-4-carboxy-butyl)imino-methyl]aminobutanedioic acid

# Chemical_Formula:
C10H18N4O6

# Chemical_Structure:
tbl_chemical:::HMDB00052_ZOOM.png:::119283157596975197

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00052_THUMB.png:::119283157365872920

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Amino Acids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
primary amine; primary aliphatic amine (alkylamine); carboxylic acid; guanidine; alpha-aminoacid

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
290.12265

# Molecular_Weight_Avg:
290.27313

# Smiles_String_isomeric:
N[C@@H](CCCNN=CN[C@@H](CC(O)=O)C(O)=O)C(O)=O

# Smiles_String_canonical:
NC(CCCNN=CNC(CC(O)=O)C(O)=O)C(O)=O

# KEGG_Compound_ID:
C03406

# BioCyc_ID:
Not Available

# PubChem_CID:
439998

# PubChem_SID:
8144809; 824103; 6235; 7885973

# OMIM_ID:
207900; 222470

# Metagene_ID:
Not Available

# BiGG_ID:
41790

# Wikipedia_ID:
Argininosuccinic acid

# METLIN_ID:
5115

# Ref_ID:
624188; 174426; 9844057; 15465784; 12701806; 12686410; 12403252; 12559843; 12408190; 484552

# ChEBI_ID:
15682

# CAS_Registry_Number:
2387-71-5

# InChI:
InChI=1/C10H18N4O6/c11-6(9(17)18)2-1-3-13-14-5-12-7(10(19)20)4-8(15)16/h5-7,13H,1-4,11H2,(H,12,14)(H,15,16)(H,17,18)(H,19,20)/t6-,7-/m0/s1

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
69.3 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
Not Available

# H2O_Solubility_Predicted:
0.853 mg/mL [Predicted by ALOGPS]

# phys_charge:
-1

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
-2.28 [Predicted by ALOGPS]; -6.3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Argininosuccinic acid.pdf:::1132562193760892318

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Argininosuccinic_acid.mol:::1132723803750823271

# SDF_File_[Text]:
tbl_chemical:::HMDB00052.sdf:::119283156802450062

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00052.pdb:::11928315715297187

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Argininosuccinic acid.gif:::1132732102843434527

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00052_peaks.txt:::1156309512158846098

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Argininosuccinic acid_C.gif:::1132737667682678492

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00052_peaks.txt:::115631070269761234

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Cytoplasm

# Tissue_Location:
Kidneys

# deuterated:
No

# Biofluid_Location:
Blood

# Concentration_[Normal]:
Not Available


# Concentration_[Abnormal]:
Not Available


# Associated_Disorders:
Argininosuccinase Deficiency; Argininosuccinic Acid Lyase Deficiency; Argininosuccinic Aciduria; Argininosuccinyl-CoA lyase deficiency; ASL Deficiency; Citrullinemia; Citrullinemia Type II

# Pathway_Names:
Alanine and aspartate metabolism

# Pathway_Images:
Aspartate_and_Alanine_metabolism.jpg

# KEGG_Images:
map00252

# Pathway_Graphs:
Aspartate_and_Alanine_metabolism_Graph.jpg

# Pathway_SBMLs:
Aspartate_and_Alanine_metabolism.xml

# Metabolic_Enzyme_1_ID:
5928

# Metabolic_Enzyme_1_Name:
Argininosuccinate synthase

# Metabolic_Enzyme_1_Synonyms:
Citrulline--aspartate ligase

# Metabolic_Enzyme_1_Gene_Name:
ASS1

# Metabolic_Enzyme_1_Protein_Sequence:
>Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK

# Metabolic_Enzyme_1_Number_of_Residues:
412

# Metabolic_Enzyme_1_Molecular_Weight:
46531

# Metabolic_Enzyme_1_Theoretical_pI:
8.18

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  binding
Function:  nucleotide binding
Function:  purine nucleotide binding
Function:  adenyl nucleotide binding
Function:  ATP binding
Function:  catalytic activity
Function:  ligase activity
Function:  ligase activity, forming carbon-nitrogen bonds
Function:  argininosuccinate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  urea cycle intermediate metabolism
Process:  arginine metabolism
Process:  arginine biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + omega-N-(L-arginino)succinate

# Metabolic_Enzyme_1_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_1_Reaction:
ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00764:Arginosuc_synth

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 6.3.4.5

# Metabolic_Enzyme_1_GenBank_ID_Protein:
28872

# Metabolic_Enzyme_1_SwissProt_ID:
ASSY_HUMAN (P00966)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
ASS1

# Metabolic_Enzyme_1_Geneatlas_id:
ASS1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:758

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Not Available

# Metabolic_Enzyme_1_Gene_Sequence:
>1239 bp
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTACGGCCTAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG

# Metabolic_Enzyme_1_GenBank_ID_Gene:
X01630

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:9

# Metabolic_Enzyme_1_Locus:
9q34.1

# Metabolic_Enzyme_1_SNPs:
rs10901072; rs877326; rs4740158; rs6597680; rs7040665; rs11243372; rs12554609; rs12004384; rs10901047; rs914983; rs12380009; rs4740435; rs10121847; rs7042129; rs10123082; rs1760275; rs11244382; rs12685110; rs474330; rs553696; rs596317; rs506705; rs602924; rs504752; rs1215983; rs6597499; rs1215971; rs1215980; rs493389; rs543048; rs1215984; rs634432; rs666174; rs914971; rs1215970; rs1653332; rs10901080; rs590086; rs1215979; rs502901; rs666971; rs1215985; rs1215990; rs12555797; rs554629; rs7860909; rs3780588; rs1215986; rs12005118; rs1215972; rs7036163; rs2043189; rs2282219; rs914970; rs480313; rs1215988; rs12551145; rs17147029; rs2991273; rs12375699; rs641510; rs486889; rs7018779; rs17147023; rs506626; rs1215981; rs10114424; rs544701; rs618504; rs11243414; rs4322051; rs548262; rs1615006; rs11789315; rs1215982; rs12340606; rs529569; rs17147021; rs507351; rs1215991; rs7039110; rs7851267; rs1864708; rs1619401; rs652313; rs502166; rs10122141; rs668738; rs476067; rs2043191; rs10901085; rs580228; rs1215978; rs2043190; rs12003032; rs12553162; rs17147018; rs1215940; rs566037; rs640181; rs7847222; rs12000999; rs1760253; rs12343715; rs1215975; rs11243474; rs12377651; rs1215987; rs7040689; rs1215976; rs584157; rs4032; rs540140; rs4740430; rs928518; rs7854616; rs688430; rs35269064; rs11549769; rs1057484; rs35772983; rs3208841; rs2297599; rs13440219; rs13290196; rs35463800; rs11243377; rs12685093; rs3012668; rs35902422; rs5900898; rs11272909; rs3085579; rs10121464; rs28534724; rs11337242; rs28511880; rs13293193; rs35000413; rs5900899; rs12340634; rs41296095; rs35487019; rs1215977; rs35835384; rs34768057; rs3780589; rs34339017; rs11243481; rs34029710; rs34271203; rs11271310; rs11243542; rs13301636; rs12171726; rs34273046; rs4740317; rs35512453; rs1653340; rs34362653; rs34654848; rs1653334; rs11243500; rs35852270; rs12376592; rs35568745; rs12343078; rs11243395; rs28440121; rs34248043; rs12378416; rs1215941; rs12375712; rs28665572; rs11243405; rs35797527; rs4740239; rs2313201; rs884804; rs3030699; rs34037515; rs35769425; rs34790521; rs1215989; rs35976100; rs35015356; rs2297598; rs10114733; rs6151195; rs41302903; rs928517; rs12344308; rs2915535; rs28634784; rs35889473; rs884803; rs35476109; rs34850609; rs596698; rs13288900; rs34421800; rs35943966; rs534737; rs28530182; rs2116393; rs11243400; rs35581111; rs12553789; rs28633982; rs4740161; rs34599158; rs35204727; rs631908; rs13288740; rs7025952; rs1467802; rs11788148; rs35842179; rs11243523; rs11243545; rs7030804; rs34149601; rs7855232; rs35220375; rs28587006; rs11244367; rs12352216; rs11244364; rs7043097; rs34734822; rs36233815; rs2071367; rs35688375; rs10793902; rs10901110; rs11244343; rs12236605; rs12337532; rs12342208; rs12345660; rs2313079; rs3087691; rs4237122; rs7041914; rs7851772; rs7865294; rs7869828; rs928516

# Metabolic_Enzyme_1_General_References:
6194510; 6321498; 11941481; 2788888; 9150948; 2358466; 1943692; 7977368; 8792870; 11708871; 12815590

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5970

# Metabolic_Enzyme_2_Name:
Argininosuccinate lyase

# Metabolic_Enzyme_2_Synonyms:
Arginosuccinase; ASAL

# Metabolic_Enzyme_2_Gene_Name:
ASL

# Metabolic_Enzyme_2_Protein_Sequence:
>Argininosuccinate lyase
MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEM
DQILHGLDKVAEEWAQGTFKLNSNDEDIHTANERRLKELIGATAGKLHTGRSRNDQVVTD
LRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVAL
TRDSERLLEVRKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVA
EFLFWASLCMTHLSRMAEDLILYCTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKA
GRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMSAVLQVATGVISTLQIHQENM
GQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQTISPLF
SGDVICVWDYGHSVEQYGALGGTARSSVDWQIRQVRALLQAQQA

# Metabolic_Enzyme_2_Number_of_Residues:
464

# Metabolic_Enzyme_2_Molecular_Weight:
51659

# Metabolic_Enzyme_2_Theoretical_pI:
6.45

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
2-(omega-N-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_2_Pathway:
map00220  Urea cycle and metabolism of amino groups;
 map00252  Alanine and aspartate metabolism;
 map00330  Arginine and proline metabolism

# Metabolic_Enzyme_2_Reaction:
(N(omega)-L-arginino)succinate = fumarate + L-arginine

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_2_Signals:
None

# Metabolic_Enzyme_2_Transmembrane_Regions:
None

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 4.3.2.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
28878

# Metabolic_Enzyme_2_SwissProt_ID:
ARLY_HUMAN (P04424)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
ASL

# Metabolic_Enzyme_2_Geneatlas_id:
ASL

# Metabolic_Enzyme_2_hgnc_id:
HGNC:746

# Metabolic_Enzyme_2_PDB_ID:
1K62

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Not Available

# Metabolic_Enzyme_2_Gene_Sequence:
>1395 bp
ATGGCCTCGGAGAGTGGGAAGCTTTGGGGTGGCCGGTTTGTGGGTGCAGTGGACCCCATC
ATGGAGAAGTTCAACGCGTCCATTGCCTACGACCGGCACCTTTGGGAGGTGGATGTTCAA
GGCAGCAAAGCCTACAGCAGGGGCCTGGAGAAGGCAGGGCTCCTCACCAAGGCCGAGATG
GACCAGATACTCCATGGCCTAGACAAGGTGGCTGAGGAGTGGGCCCAGGGCACCTTCAAA
CTGAACTCCAATGATGAGGACATCCACACAGCCAATGAGCGCCGCCTGAAGGAGCTCATT
GGTGCAACGGCAGGGAAGCTGCACACGGGACGGAGCCGGAATGACCAGGTGGTCACAGAC
CTCAGGCTGTGGATGCGGCAGACCTGCTCCACGCTCTCGGGCCTCCTCTGGGAGCTCATT
AGGACCATGGTGGATCGGGCAGAGGCGGAACGTGATGTTCTCTTCCCGGGGTACACCCAT
TTGCAGAGGGCCCAGCCCATCCGCTGGAGCCACTGGATTCTGAGCCACGCCGTGGCACTG
ACCCGAGACTCTGAGCGGCTGCTGGAGGTGCGGAAGCGGATCAATGTCCTGCCCCTGGGG
AGTGGGGCCATTGCAGGCAATCCCCTGGGTGTGGACCGAGAGCTGCTCCGAGCAGAACTC
AACTTTGGGGCCATCACTCTCAACAGCATGGATGCCACTAGTGAGCGGGACTTTGTGGCC
GAGTTCCTGTTCTGGCGTTCGCTGTGCATGACCCATCTCAGCAGGATGGCCGAGGACCTC
ATCCTCTACTGCACCAAGGAATTCAGCTTCGTGCAGCTCTCAGATGCCTACAGCACGGGA
AGCAGCCTGATGCCCCAGAAGAAAAACCCCGACAGTTTGGAGCTGATCCGGAGCAAGGCT
GGGCGTGTGTTTGGGCGGTGTGCCGGGCTCCTGATGACCCTCAAGGGACTTCCCAGCACC
TACAACAAAGACTTACAGGAGGACAAGGAAGCTGTGTTTGAAGTGTCAGACACTATGAGT
GCCGTGCTCCAGGTGGCCACTGGCGTCATCTCTACGCTGCAGATTCACCAAGAGAACATG
GGACAGGCTCTCAGCCCCGACATGCTGGCCACTGACCTTGCCTATTACCTGGTCCGCAAA
GGGATGCCATTCCGCCAGGCCCATGAGGCCTCCGGGAAAGCTGTGTTCATGGCCGAGACC
AAGGGGGTCGCCCTCAACCAGCTGTCACTGCAGGAGCTGCAGACCATCAGCCCCCTGTTC
TCGGGCGACGTGATCTGCGTGTGGGACTACCGGCACAGTGTGGAGCAGTATGGTGCCCTG
GGCGGCACTGCGCGCTCCAGCGTCGACTGGCAAATCCGCCAGGTGCGGGCGCTACTGCAG
GCACAGCAGGCCTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
Y00753

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_2_Locus:
7cen-q11.2

# Metabolic_Enzyme_2_SNPs:
rs465359; rs160644; rs462853; rs1167406; rs1144895; rs313830; rs313829; rs12530898; rs1167408; rs2460432; rs160648; rs1183245; rs780998; rs2220626; rs10276931; rs12536292; rs316336; rs160647; rs160657; rs160646; rs160645; rs313831; rs697969; rs7455802; rs7455801; rs3116476; rs28941472; rs3107306; rs28940585; rs160643; rs34720698; rs2292938; rs35348667; rs4281011; rs160649; rs35930194; rs313828; rs13247295; rs35529535; rs34583147; rs34661440; rs6955131; rs160656; rs1144894; rs35350184; rs6967430; rs313833; rs313832; rs10699464; rs28447397; rs28566023; rs160543; rs35718690; rs7812266; rs10247708; rs160642; rs35701961; rs1167411; rs10234562; rs12531358; rs12532327; rs160652; rs160654; rs697970; rs709609

# Metabolic_Enzyme_2_General_References:
3391281; 3463959; 2644168; 9256435; 11747432; 1705937; 2263616; 12408190

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5857

# Metabolic_Enzyme_3_Name:
Adenylosuccinate lyase

# Metabolic_Enzyme_3_Synonyms:
Adenylosuccinase; ASL; ASASE

# Metabolic_Enzyme_3_Gene_Name:
ADSL

# Metabolic_Enzyme_3_Protein_Sequence:
>Adenylosuccinate lyase
MAAGGDHGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDE
QIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTD
LIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLC
MDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITG
QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMR
SERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISE
GLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGD
NDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKA
ELCL

# Metabolic_Enzyme_3_Number_of_Residues:
484

# Metabolic_Enzyme_3_Molecular_Weight:
54890

# Metabolic_Enzyme_3_Theoretical_pI:
7.12

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  lyase activity
Function:  carbon-nitrogen lyase activity
Function:  amidine-lyase activity
Function:  adenylosuccinate lyase activity
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide metabolism
Process:  purine nucleotide metabolism
Process:  purine nucleotide biosynthesis
Process:  purine ribonucleotide biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Nucleotide transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
6-N-(1,2-dicarboxyethyl)AMP = fumarate + AMP

# Metabolic_Enzyme_3_Pathway:
map00230  Purine metabolism;
 map00252  Alanine and aspartate metabolism

# Metabolic_Enzyme_3_Reaction:
(1) N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP; (2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00206:Lyase_1

# Metabolic_Enzyme_3_Signals:
None

# Metabolic_Enzyme_3_Transmembrane_Regions:
None

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 4.3.2.2

# Metabolic_Enzyme_3_GenBank_ID_Protein:
28904

# Metabolic_Enzyme_3_SwissProt_ID:
PUR8_HUMAN (P30566)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
ADSL

# Metabolic_Enzyme_3_Geneatlas_id:
ADSL

# Metabolic_Enzyme_3_hgnc_id:
HGNC:291

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Not Available

# Metabolic_Enzyme_3_Gene_Sequence:
>1455 bp
ATGGCGGCTGGAGGCGATCATGGTTCGCCCGACAGCTACCGCTCACCTCTTGCCTCCCGC
TATGCCAGCCCGGAGATGTGCTTCGTGTTTAGCGACAGGTATAAATTCCGGACATGGCGG
CAGCTGTGGCTGTGGCTGGCGGAGGCCGAGCAGACATTGGGTTTGCCTATCACAGATGAA
CAAATCCAGGAGATGAAATCAAACCTGGAGAACATAGACTTCAAGATGGCAGCTGAGGAA
GAGAAACGTTTACGACATGATGTGATGGCTCACGTGCACACATTTGGCCACTGCTGTCCA
AAAGCTGCAGGCATTATTCACCTTGGTGCTACTTCTTGCTATGTTGGAGACAATACTGAC
TTGATTATTCTTAGAAATGCACTTGACCTGCTTTTGCCAAAGCTTGCCAGAGTGATCTCT
CGGCTTGCCGACTTTGCTAAGGAACGAGCCAGTCTACCCACATTAGGTTTCACACATTTC
CAGCCTGCACAGCTGACCACAGTTGGGAAACGTTGCTGTCTTTGGATTCAGGATCTTTGC
ATGGATCTCCAGAACTTGAAGCGTGTCCGAGATGACCTGCGCTTCCGGGGAGTAAAGGGT
ACCACTGGCACTCAGGCCAGTTTCCTGCAGCTCTTTGAGGGAGATGACCATAAGGTAGAG
CAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTTAAGAGAGCTTTCATCATCACAGGG
CAGACATATACACGAAAAGTGGATATTGAAGTACTGTCTGTGCTGGCTAGCTTGGGGGCA
TCAGTGCACAAGATTTGCACCGACATACGCCTCCTGGCAAACCTCAAGGAGATGGAGGAA
CCCTTTGAAAAACAGCAGATTGGCTCAAGTGCGATGCCATATAAGCGGAATCCCATGCGT
TCAGAACGTTGCTGCAGTCTTGCCCGCCACCTGATGACCCTTGTCATGGACCCGCTACAG
ACAGCATCTGTCCAGTGGTTTGAACGCACACTGGATGATAGTGCCAACCGACGGATCTGT
TTGGCCGAGGCATTTCTTACCGCAGATACTATATTGAATACGCTGCAGAACATTTCTGAA
GGATTGGTCGTGTACCCCAAAGTAATTGAACGGCGCATTCGGCAAGAGCTGCCTTTCATG
GCCACAGAGAACATCATCATGGCCATGGTCAAAGCTGGAGGTAGCCGCCAGGATTGCCAT
GAGAAAATCAGAGTGCTTTCTCAGCAGGCAGCTTCTGTGGTTAAGCAGGAAGGGGGTGAC
AATGACCTCATAGAGCGTATCCAGGTTGATGCCTACTTCAGTCCCATTCACTCCCAGTTG
GATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTGCAGAGATTC
TTAGAAGAGGAGGTGTATCCCCTGTTAAAACCATATGAAAGCGTGATGAAGGTGAAAGCA
GAATTATGTCTGTAG

# Metabolic_Enzyme_3_GenBank_ID_Gene:
X65867

# Metabolic_Enzyme_3_Chromosome_Location:
Chromosome:22

# Metabolic_Enzyme_3_Locus:
22q13.1|22q13.2

# Metabolic_Enzyme_3_SNPs:
rs2068470; rs3788578; rs3788579; rs3788577; rs9611321; rs8135371; rs7291418; rs17001846; rs10854729; rs11913275; rs2280790; rs2075764; rs12160297; rs5757922; rs17001863; rs17001848; rs17001857; rs4321458; rs2006965; rs909669; rs12484610; rs5757921; rs8192461; rs11089991; rs8192457; rs34396910; rs8192454; rs2735668; rs11703124; rs8192453; rs8192458; rs2743718; rs17001854; rs5995848; rs2743725; rs2735660; rs2735669; rs34476033; rs2735672; rs4820411; rs2743716; rs6001886; rs35043528; rs35572733; rs5995847; rs2743723; rs2735665; rs10427931; rs11089990; rs2743721; rs12170384; rs2743728; rs2743719; rs8192455; rs2735667; rs8192460; rs1882824; rs5757924; rs36099663; rs2735663; rs2735673; rs2743717; rs10427911; rs28699192; rs2743726; rs3830737; rs2743724; rs7285719; rs6001887; rs8192452; rs28642715; rs9611322; rs5750935; rs2735664; rs2735666; rs8192459; rs11431892; rs9611323; rs1882823; rs35553188; rs8142978; rs2743729; rs2743722; rs5757923; rs2735661; rs8192456; rs35401769; rs2743727; rs17001850; rs2743720; rs35128658; rs3044501; rs2743731; rs742139; rs2006961; rs909205; rs5995846; rs9607708; rs5757920; rs2743714; rs751367; rs5995845; rs5757918; rs16985898; rs9611320; rs2743732; rs35992774; rs909204; rs11320845; rs2743730; rs2743715; rs10650685; rs5757919; rs2743713; rs12484697; rs4619722; rs5995844; rs6001883; rs6001888; rs9611310; rs9611311; rs9611312; rs9611314; rs9611316; rs9611318; rs9623170

# Metabolic_Enzyme_3_General_References:
10888601; 10591208; 1302001; 9545543; 10090474; 10958654; 12368987

# Metabolic_Enzyme_3_References:
282632; 6777600

End of HMDB00052

Beginning of HMDB00053
# Accession_No:
HMDB00053

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:29:25

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Androstenedione

# Description:
A delta-4 19-carbon steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX.  Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.  It is the common precursor of male and female sex hormones. Some androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens. Androstenedione originates either from the conversion of dehydroepiandrosterone or from 17-hydroxyprogesterone. It is further converted to either testosterone or estrone. The production of adrenal androstenedione is governed by ACTH, while production of gonadal androstenedione is under control by gonadotropins.

# Synonyms:
(4)-Androsten-3,17-dione; 17-Ketotestosterone; 3,17-Dioxoandrost-4-ene; 4-Androsten-3,17-dione; 4-Androstene-3,17-dione; 4-androstenedione; delta4-androstenedione; Androst-4-ene-3,17-dione; Androstenedione; androstendione; D4-Androstene-3,17-dione; Fecundin; [4-14C]-androstenedione; [4-14C]androst-4-ene-3,17-dione

# Chemical_IUPAC_Name:
10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

# Chemical_Formula:
C19H26O2

# Chemical_Structure:
tbl_chemical:::HMDB00053_ZOOM.png:::11928315887757840

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00053_THUMB.png:::11928315867232208

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Steroids

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
ketone; alkene

# Taxonomy_Biofunction:
Not Available

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
286.19327

# Molecular_Weight_Avg:
286.40854

# Smiles_String_isomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CCC2=O

# Smiles_String_canonical:
CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2=O

# KEGG_Compound_ID:
C00280

# BioCyc_ID:
ANDROST4ENE

# PubChem_CID:
6128

# PubChem_SID:
7885977; 933828; 598429; 3575; 8145630; 75016; 3162127; 11076124; 149021; 841441; 7847119; 11076123; 855972; 8153839

# OMIM_ID:
139300; 146110; 169170; 184700; 201810; 264300

# Metagene_ID:
Not Available

# BiGG_ID:
2210012

# Wikipedia_ID:
Androstenedione

# METLIN_ID:
2795

# Ref_ID:
3924954; 16855166; 1620285; 12096825; 15522925; 7192922; 10863969; 10421267; 6100340; 10359391; 10356596; 8706310; 11762080; 16890572; 2758640; 8877606; 15878571; 16030098; 7055782

# ChEBI_ID:
16422

# CAS_Registry_Number:
63-05-8

# InChI:
InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

# Synthesis_Reference:
Journal of the American Chemical Society  (1945),  67  1728-20.

# Melting_Point:
170-173 oC

# Melting_Point_predicted:
121.6 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.0578 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

# H2O_Solubility_Predicted:
0.027 mg/mL [Predicted by ALOGPS]

# phys_charge:
0

# State:
Solid

# LogP:
2.75 [HANSCH,C ET AL. (1995)]

# LogP_predicted:
2.93 [Predicted by ALOGPS]; 3 [Predicted by PubChem via XLOGP]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Androstenedione.pdf:::1132562194050625366

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Androstenedione.mol:::1132723803828452408

# SDF_File_[Text]:
tbl_chemical:::HMDB00053.sdf:::11928315799624453

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00053.pdb:::119283158484168880

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:


# H_NMR_FIDS_Spectra_Wishart:
tbl_hnmrw:::050115_P00_02_IS_1DP.zip:::117104569203712001

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:


# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140.png:::116655945200365634

# 2D_HSQC_FIDS_Spectra:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140.zip:::116655945202777332

# 2d_HSQC_Instrument_Manufacturer:
Bruker

# Assignemnt_For_NMR_Spectra_2DHSQC:
tbl_hsqc2d:::050115_P00_02_IS_2DHSQC_140_Assigned.png:::116655945245975254

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Androstenedione.gif:::1132732103046722250

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00053_peaks.txt:::1156309513192192671

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Androstenedione_C.gif:::1132737668293616065

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00053_peaks.txt:::1156310703709458120

# Mass_Spectrum:
Low Energy:tbl_ms:::HMDB00053L.png:::119015630226397208; Medium Energy:tbl_ms:::HMDB00053M.png:::119015630168993754; High Energy:tbl_ms:::HMDB00053H.png:::119015630282979457

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane; Cytoplasm; endoplasmic reticulum

# Tissue_Location:
Adipose Tissue; Adrenal Cortex; Adrenal Gland; Fibroblasts; Gonads; Kidneys; Liver; Muscle; Placenta; Prostate; Skin; Testes; Testis

# deuterated:
No

# Biofluid_Location:
Blood; CSF; Synovial Fluid

# Concentration_[Normal]:
Blood	0.0059 (0.0023-0.0094)	umol/L	Adult:>18_yrs_old	Both	Normal	Merck Manual
Blood	0.0022 (0.001-0.0034)	uM	Children:1-13_yrs_old	Both	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0065 (0.004 - 0.009)	uM	Adult:>18_yrs_old	N/A	Normal	16890572
Blood	0.005 (0.0024-0.007)	uM	Adolescent:13-18_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0040 (0.0013-0.0066)	uM	Children:1-13_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.001 (0.00034-0.0017)	uM	Children:1-13_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Blood	0.0057 (0.00069-0.01)	uM	Adult:>18_yrs_old	Female	Normal	Mayo Medical Laboratories 2005 Test Catalog
Cerebrospinal_Fluid(CSF)	0.00101 (0.00002-0.002)	umol/L	Adult:>18_yrs_old	N/A	Normal	1620285


# Concentration_[Abnormal]:
Blood	0.00315 (0.0- 0.0063)	umol/L	Adult:>18_yrs_old	Female	 Post-menopausal	Merck Manual


# Associated_Disorders:
 Post-menopausal; Hydroxylase Deficiency; Oligomenorrhea; Polycystic Ovary Syndrome (PCOS); Prostatic Carcinoma

# Pathway_Names:
Bile acid biosynthesis;C21-Steroid hormone metabolism;Androgen and estrogen metabolism

# Pathway_Images:
;;

# KEGG_Images:
map00120;map00140;map00150

# Pathway_Graphs:
;;

# Pathway_SBMLs:
;;

# Metabolic_Enzyme_1_ID:
5822

# Metabolic_Enzyme_1_Name:
3-oxo-5-beta-steroid 4-dehydrogenase

# Metabolic_Enzyme_1_Synonyms:
Delta(4-3- ketosteroid 5-beta-reductase; Aldo-keto reductase family 1 member D1

# Metabolic_Enzyme_1_Gene_Name:
AKR1D1

# Metabolic_Enzyme_1_Protein_Sequence:
>3oxo5betasteroid 4dehydrogenase
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIRE
KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYII
EVPMAFKPGDEIYPRDENGKW
LYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL
ILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQ
QHDIVITAYSPLGTSRNPIWVNVSSPP
LLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERI
KENFQIFDFSLTEEEM
KDIEALNKNVRFVELLMWRDHPEYPFHDEY

# Metabolic_Enzyme_1_Number_of_Residues:
326

# Metabolic_Enzyme_1_Molecular_Weight:
37377

# Metabolic_Enzyme_1_Theoretical_pI:
7.58

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Not Available

# Metabolic_Enzyme_1_Specific_Function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates

# Metabolic_Enzyme_1_Pathway:
map00140  C21-Steroid hormone metabolism

# Metabolic_Enzyme_1_Reaction:
4,5beta-dihydrocortisone + NADP+ = cortisone + NADPH + H+

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00248:Aldo_ket_red

# Metabolic_Enzyme_1_Signals:
None

# Metabolic_Enzyme_1_Transmembrane_Regions:
None

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 1.3.1.3

# Metabolic_Enzyme_1_GenBank_ID_Protein:
431857

# Metabolic_Enzyme_1_SwissProt_ID:
AK1D1_HUMAN (P51857)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
AKR1D1

# Metabolic_Enzyme_1_Geneatlas_id:
AKR1D1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:388

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_1_Gene_Sequence:
>981 bp

ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCAT
CATCGGACTTG
GTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACAT
CGGTGAAGGTTGCTATTGACAC
AGGGTACCGACATATTGATGGGGCCTACATCTACCAA
AATGAACACGAAGTTGGGGAGGCCATCAGGGAG
AAGATAGCAGAAGGAAAGGTGCGGAG
GGAAGATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATG
TCCCAGAGATGGTCC
GCCCAACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTA
CATC
ATTGAAGTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGC
AAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAA
AGACGCTGGCTTGGTGA
AATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGC
TCATCCTGAACAAGCCAGGACTCAAACA
CAAGCCAGTCAGCAACCAGGTTGAGTGCCAT
CCGTATTTCACCCAGCCAAAACTCTTGAAATTTTGCCAA
CAACATGACATTGTCATTAC
TGCATATAGCCCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTT
CTTCTCCAC
CTTTGTTAAAGGATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTC
A
AATTGTTTTGCGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAAT
CTTGAAAGGATC
AAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAAT
GAAGGACATTGAAGCCTTGAATA
AAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCG
ATCATCCTGAATACCCATTTCATGATGAATACTG
A

# Metabolic_Enzyme_1_GenBank_ID_Gene:
Z28339

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_1_Locus:
7q32-q33

# Metabolic_Enzyme_1_SNPs:
rs34703687; rs1872929; rs7780066; rs3735023; rs1872930; rs11763625; rs7799169; rs17169523; rs12540339; rs12532715; rs7780438; rs11763063; rs17169522; rs2306847; rs3805361; rs2120846; rs6467736; rs2035648; rs11982192; rs6467734; rs7799130; rs10263205; rs10280818; rs2166188; rs10269530; rs10257928; rs3805360; rs7784881; rs7795946; rs6956827; rs10226024; rs10278929; rs4728430; rs10236161; rs10954603; rs12111721; rs10228704; rs8180809; rs10276854; rs6943498; rs17169518; rs12668157; rs6980334; rs2035736; rs10263802; rs17169521; rs10954602; rs2306845; rs3805362; rs10264658; rs9642091; rs6945659; rs7799647; rs3857868; rs7784424; rs6943935; rs6951769; rs12670660; rs17169511; rs12670239; rs7799469; rs2306846; rs17169513; rs7783021; rs10279265; rs10229533; rs7784068; rs1872928; rs7803336; rs17543126; rs7784561; rs7784275; rs10244249; rs7780347; rs1038626; rs6467735; rs6977075; rs10264216; rs10279757; rs7797080; rs10228366; rs10280628; rs11762514; rs2352140; rs2035647; rs7794061; rs10280600; rs17169512; rs7784563; rs7788077; rs2882947; rs6962195; rs3816829; rs10230440; rs7784075; rs10258807; rs10085803; rs10229164; rs10236488; rs4732288; rs10244250; rs3807332; rs10246884; rs7779865; rs10231078; rs11766258; rs2465921; rs12540340; rs2465920; rs35535735; rs10274304; rs13243518; rs28601801; rs35429213; rs4732290; rs10230015; rs192475; rs13239794; rs10271851; rs4141795; rs28533201; rs11378949; rs35063839; rs10276951; rs13243967; rs9642092; rs10230284; rs28853972; rs35402657; rs34205888; rs10276855; rs6975550; rs35473428; rs28698638; rs1186272; rs13228410; rs28378643; rs13243508; rs41274197; rs34060691; rs28479257; rs36119043; rs596658; rs13244061; rs13243992; rs13243602; rs10541658; rs10280394; rs7803480; rs10230507; rs35802315; rs2465083; rs13223644; rs9642093; rs41274194; rs35504713; rs34727188; rs28609414; rs34315519; rs3857869; rs34005857; rs5887865; rs35808917; rs13243764; rs1186273; rs10264483; rs10229138; rs7784629; rs34809975; rs10259579; rs35109728; rs34437071; rs28558091; rs34613519; rs35807033; rs35415283; rs13243510; rs7787591; rs3902226; rs28547527; rs34789634; rs28587485; rs10259580; rs11762575; rs11975510; rs4311613; rs11269285; rs35579520; rs35629548; rs34739493; rs35926233; rs10227099; rs10228772; rs10233399; rs10233624; rs10235317; rs10243853; rs10258577; rs1025967; rs10260689; rs10265064; rs10954601; rs11760991; rs11764114; rs11976842; rs1487999; rs1488000; rs1586497; rs1601823; rs17169507; rs17169524; rs17277937; rs1817686; rs1994462; rs2440798; rs2440799; rs2440801; rs2465911; rs2633359; rs2709984; rs2859828; rs34416298; rs3757393; rs4732285; rs6942538; rs6950501; rs6960318; rs7785557; rs7796011; rs7796171; rs7812287; rs9692029

# Metabolic_Enzyme_1_General_References:
7508385; 11342103

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5737

# Metabolic_Enzyme_2_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II

# Metabolic_Enzyme_2_Synonyms:
3- beta-HSD II[Includes: 3-beta-hydroxy-Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta- 5-3-ketosteroid isomerase]

# Metabolic_Enzyme_2_Gene_Name:
HSD3B2

# Metabolic_Enzyme_2_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type II
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKR
ACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNG
HEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDT
LYTCALRPTYIYGEGGPFLSASINEALNNNGI
LSSVGKFSTVNPVYVGNVAWAHILALR
ALRDPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLD
SRWSLPLTLMYWIGFL
LEVVSFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQ
KTVEW
VGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_2_Number_of_Residues:
372

# Metabolic_Enzyme_2_Molecular_Weight:
42053

# Metabolic_Enzyme_2_Theoretical_pI:
8.17

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_2_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_2_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_2_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_2_Signals:
1-15

# Metabolic_Enzyme_2_Transmembrane_Regions:
287-307

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_2_GenBank_ID_Protein:
184401

# Metabolic_Enzyme_2_SwissProt_ID:
3BHS2_HUMAN (P26439)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
HSD3B2

# Metabolic_Enzyme_2_Geneatlas_id:
HSD3B2

# Metabolic_Enzyme_2_hgnc_id:
HGNC:5218

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_2_Gene_Sequence:
>1119 bp

ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCG
CCTGTTGGTGG
AAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGAC
CAGAATTGAGAGAGGAATTTTC
TAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAA
GGAGACATTCTGGATGAGCCATTCCTGAAAAGA
GCCTGCCAGGACGTCTCGGTCGTCAT
CCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAG
AGTCCATCATGAATG
TCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCC
AGTC
TTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAG
AACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAA
AAAGCTTGCTGAGAAGG
CTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATA
CCTTGTACACTTGTGCGTTAAGACCCAC
ATATATCTATGGGGAAGGAGGCCCATTCCTT
TCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATC
CTGTCAAGTGTTGGAAAGTT
CTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTC
TGGCCTTGA
GGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAG
A
TGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGC
CTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCT
GCTGGAAGTAGTGAGCTTCCTAC
TCAGCCCAATTTACTCCTATCAACCCCCCTTCAACC
GCCACACAGTCACATTATCAAATAGTGTGTTCAC
CTTCTCTTACAAGAAGGCTCAGCGA
GATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAG
AAAACCGTGGAGTG
GGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

# Metabolic_Enzyme_2_GenBank_ID_Gene:
M67466

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:1

# Metabolic_Enzyme_2_Locus:
1p13.1

# Metabolic_Enzyme_2_SNPs:
rs4986954; rs6211; rs35887327; rs6207; rs33926546; rs34412477; rs33932258; rs1819698; rs1361530; rs9282704; rs6208; rs6210; rs9282703; rs3753258; rs12411115; rs2854961; rs33920337; rs17023577; rs12044792; rs2854964; rs10923817; rs3765948; rs12411080; rs2854963; rs2793133; rs7411891; rs2854962; rs2793132; rs6676988; rs4659174; rs12062744; rs33952871; rs33963971; rs4659175; rs35983269; rs34492690; rs34177617; rs35954381; rs35344469; rs35569514; rs9282705; rs28943871; rs35613222; rs28934880; rs35486059; rs34562248; rs714748; rs10591825; rs10616581; rs34234813; rs12741109; rs3057393; rs35081017; rs3820030; rs6692175; rs10616582; rs12742063; rs12404035; rs12741125; rs36021225; rs36022499; rs5777392; rs12723698; rs35507723; rs35448442; rs35847875; rs34282330; rs10754396; rs10923815; rs10923819; rs10923820; rs11579951; rs12022215; rs12403392; rs12404131; rs12405488; rs1341018; rs17023564; rs2185556; rs2185557; rs6661603; rs947129

# Metabolic_Enzyme_2_General_References:
1944309; 1741954; 8316254; 7833923; 8126127; 7962268; 8185809; 8060486; 7893703; 7633426; 7633460; 7608265; 9719627; 10599696; 10651755; 10843183; 12050213

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5738

# Metabolic_Enzyme_3_Name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I

# Metabolic_Enzyme_3_Synonyms:
3- beta-HSD I; Trophoblast antigen FDO161G[Includes: 3-beta-hydroxy- Delta(5-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta- isomerase; Delta-5-3-ketosteroid isomerase]

# Metabolic_Enzyme_3_Gene_Name:
HSD3B1

# Metabolic_Enzyme_3_Protein_Sequence:
>3 betahydroxysteroid dehydrogenase/Delta 5>4isomerase type I
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLE
GDILDEPFLK
RACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPV
FIYTSSIEVAGPNSYKEIIQN
GHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASINEALNNNG
ILSSVGKFSTVNPVYVGNVAWAHILAL
RALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRL
DSRWSFPLSLMYWIGF
LLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAK
QKTVE
WVGSLVDRHKETLKSKTQ

# Metabolic_Enzyme_3_Number_of_Residues:
373

# Metabolic_Enzyme_3_Molecular_Weight:
42252

# Metabolic_Enzyme_3_Theoretical_pI:
8.98

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  isomerase activity
Function:  intramolecular oxidoreductase activity
Function:  intramolecular oxidoreductase activity, transposing C=C bonds
Function:  steroid delta-isomerase activity
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on CH-OH group of donors
Function:  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Function:  steroid dehydrogenase activity
Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  primary metabolism
Process:  lipid metabolism
Process:  cellular lipid metabolism
Process:  steroid metabolism
Process:  steroid biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_3_Specific_Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids

# Metabolic_Enzyme_3_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_3_Reaction:
A 3-oxo-delta5-steroid = a 3-oxo-delta4-steroid

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF01073:3Beta_HSD

# Metabolic_Enzyme_3_Signals:
1-13

# Metabolic_Enzyme_3_Transmembrane_Regions:
288-308

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 1.1.1.145;EC 5.3.3.1

# Metabolic_Enzyme_3_GenBank_ID_Protein:
306889

# Metabolic_Enzyme_3_SwissProt_ID:
3BHS1_HUMAN (P14060)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
HSD3B1

# Metabolic_Enzyme_3_Geneatlas_id:
HSD3B1

# Metabolic_Enzyme_3_hgnc_id:
HGNC:5217

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Endoplasmic reticulum; endoplasmic reticulum membrane; single-pass membrane protein. Mitochondrion; mitochondrial membrane; single-pass membrane protein

# Metabolic_Enzyme_3_Gene_Sequence:
>1122 bp

ATGACGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGTTTCTGGGACAGAGGATCAT
CCGCCTCTTGG
TGAAGGAGAAGGAGCTGAAGGAGATCAGGGTCTTGGACAAGGCCTTCG
GACCAGAATTGAGAGAGGAATT
TTCTAAACTCCAGAACAAGACCAAGCTGACAGTGCTG
GAAGGAGACATTCTGGATGAGCCATTCCTGAAG
AGAGCCTGCCAGGACGTCTCGGTCAT
CATCCACACCGCCTGTATCATTGATGTCTTCGGTGTCACTCACA
GAGAGTCTATCATGA
ATGTCAATGTGAAAGGTACCCAGCTCCTGTTAGAGGCCTGTGTCCAAGCTAGTGT
GCCA
GTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATC
CAGAAT
GGCCATGAAGAAGAGCCTCTGGAAAACACATGGCCCGCTCCATACCCACACAG
CAAAAAGCTTGCTGAGA
AGGCTGTACTGGCGGCTAACGGGTGGAATCTGAAAAACGGCG
GCACCCTGTACACTTGTGCCTTACGACC
CATGTATATCTATGGGGAAGGAAGCCGATTC
CTTTCTGCTAGTATAAACGAGGCCCTGAACAACAATGGG
ATCCTGTCAAGTGTTGGAAA
GTTCTCCACTGTTAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACA
TTCTGGCCT
TGAGGGCCCTGCAGGACCCCAAGAAGGCCCCAAGCATCCGAGGACAGTTCTACTATATCT
C
AGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACACCCTGAGCAAAGAGTTC
GGCCTCCGCCTT
GATTCCAGATGGAGCTTTCCTTTATCCCTGATGTATTGGATTGGCTT
CCTGCTGGAAATAGTGAGCTTCC
TACTCAGGCCAATTTACACCTATCGACCGCCCTTCA
ACCGCCACATAGTCACATTGTCAAATAGCGTATT
CACCTTCTCTTATAAGAAGGCTCAG
CGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAG
CAGAAAACGGTGGA
GTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGT
GA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
M27137

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
2779585; 2139411; 2082186; 2243100; 1920284; 1401999; 10391209

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5808

# Metabolic_Enzyme_4_Name:
Cytochrome P450 11B2, mitochondrial precursor

# Metabolic_Enzyme_4_Synonyms:
CYPXIB2; P-450Aldo; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme; Steroid 18-hydroxylase; P-450C18

# Metabolic_Enzyme_4_Gene_Name:
CYP11B2

# Metabolic_Enzyme_4_Protein_Sequence:
>Cytochrome P450 11B2, mitochondrial precursor
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN

# Metabolic_Enzyme_4_Number_of_Residues:
503

# Metabolic_Enzyme_4_Molecular_Weight:
57561

# Metabolic_Enzyme_4_Theoretical_pI:
9.78

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_4_Specific_Function:
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone

# Metabolic_Enzyme_4_Pathway:
map00140  C21-Steroid hormone metabolism;
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2);
            MMU: 13072(Cyp11b2) 223628(LOC223628);
            RNO: 24293(Cyp11b1) 24294(Cyp11b2) 353498(Cyp11b3)

# Metabolic_Enzyme_4_Reaction:
corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_4_Signals:
None

# Metabolic_Enzyme_4_Transmembrane_Regions:
None

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 1.14.15.4;EC 1.14.15.5

# Metabolic_Enzyme_4_GenBank_ID_Protein:
181340

# Metabolic_Enzyme_4_SwissProt_ID:
C11B2_HUMAN (P19099)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
CYP11B2

# Metabolic_Enzyme_4_Geneatlas_id:
CYP11B2

# Metabolic_Enzyme_4_hgnc_id:
HGNC:2592

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_4_Gene_Sequence:
>1512 bp
ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTGCCTGCAAAGG
GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC
ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATGTGGAGGGAGCAGGGT
TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG
CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCATCAGA
CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTTGAATGGGCCTGAATGGCGCTTCAAC
CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG
GTGGATGCAGTGGCCAGGGACTTTTCCCAGGCCCTGAGGAAGAAGGTGCTGCAGAACGCC
CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAGCCAGC
AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC
CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG
CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG
GACTGCATCTTCCAGTACGGTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC
AACCGCCCTCAACACTACACAGGCATCGTGGCAGAGCTCCTGTTGAAGGCGGAACTGTCA
CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACGACAGCG
TTTCCGTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG
CGCAAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC
GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTCTACCCTGTGGGTCTG
TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG
ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT
GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTGCACCAC
GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG
CTGCTGCTGCTGCACCACGTGCTGAAGCGCTTCCTGGTGGAGACACTAACTCAAGAGGAC
ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA
GCGATTAACTAG

# Metabolic_Enzyme_4_GenBank_ID_Gene:
M32881

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_4_Locus:
8q21-q22

# Metabolic_Enzyme_4_SNPs:
rs4545; rs4544; rs6441; rs4537; rs4539; rs5312; rs6438; rs4536; rs4543; rs4538; rs5310; rs5313; rs5281; rs4546; rs3802230; rs3839864; rs3097; rs3802228; rs3201271; rs6431; rs6435; rs7461740; rs6397; rs6432; rs6429; rs11781816; rs6421; rs10107682; rs10090630; rs4072020; rs6399; rs10096239; rs6396; rs10099658; rs4736320; rs6433; rs7836572; rs13276226; rs5307; rs10099052; rs6418; rs6434; rs6416; rs10086846; rs12679242; rs6414; rs10110732; rs6415; rs11779229; rs6394; rs5306; rs6413; rs10090037; rs7463212; rs1799998; rs6471583; rs11781082; rs10087214; rs6992689; rs11991278; rs6440; rs12542987; rs5305; rs28931609; rs5315; rs5317; rs28930074; rs9297975; rs3201269; rs33921450; rs7463238; rs35574522; rs28390200; rs28491316; rs3201272; rs33936656; rs13257266; rs13268153; rs28531895; rs33911914; rs28361356; rs35733998; rs5895735; rs35490512; rs28526467; rs36018151; rs34144193; rs6436; rs28366703; rs13257680; rs1574565; rs5314; rs35909170; rs28394055; rs13263682; rs28615142; rs28497862; rs13252628; rs13257267; rs28659182; rs13268025; rs5895734; rs10956996; rs34951350; rs7463148; rs10623281; rs13254375; rs34884498; rs7464883; rs1800534; rs10096393; rs10108843; rs11775009; rs12546357; rs13267320; rs35431302; rs4379428; rs4736317; rs4736318; rs4736319; rs4736355; rs4736356; rs4736357; rs4736358; rs4736359; rs4736360; rs6471580; rs6471581; rs6471586; rs6651273; rs6981918; rs6987382; rs7004863; rs7011830; rs7011889; rs7011901; rs7016924; rs7460125; rs7819943; rs7820667; rs7821838; rs7824229; rs7828967; rs7831617; rs7844961; rs9643358

# Metabolic_Enzyme_4_General_References:
2592361; 2256920; 1594605; 1346492; 8439335; 9177280; 9625333; 9814506; 9931115; 10391209; 10391210; 11238478; 12788848

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5971

# Metabolic_Enzyme_5_Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2

# Metabolic_Enzyme_5_Synonyms:
Steroid 5- alpha-reductase 2; SR type 2; 5 alpha-SR2; Type II 5-alpha reductase

# Metabolic_Enzyme_5_Gene_Name:
SRD5A2

# Metabolic_Enzyme_5_Protein_Sequence:
>3oxo5alphasteroid 4dehydrogenase 2
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF

# Metabolic_Enzyme_5_Number_of_Residues:
254

# Metabolic_Enzyme_5_Molecular_Weight:
28394

# Metabolic_Enzyme_5_Theoretical_pI:
9.62

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_5_General_Function:
Not Available

# Metabolic_Enzyme_5_Specific_Function:
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology

# Metabolic_Enzyme_5_Pathway:
map00120  Bile acid biosynthesis;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_5_Reaction:
a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-delta4-steroid + reduced acceptor

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF02544:Steroid_dh

# Metabolic_Enzyme_5_Signals:
1-34

# Metabolic_Enzyme_5_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 1.3.99.5

# Metabolic_Enzyme_5_GenBank_ID_Protein:
338469

# Metabolic_Enzyme_5_SwissProt_ID:
S5A2_HUMAN (P31213)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
SRD5A2

# Metabolic_Enzyme_5_Geneatlas_id:
SRD5A2

# Metabolic_Enzyme_5_hgnc_id:
HGNC:11285

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome; microsomal membrane; multi-pass membrane protein

# Metabolic_Enzyme_5_Gene_Sequence:
>765 bp
ATGCAGGTTCAGTGCCAGCAGAGCCCAGTGCTGGCAGGCAGCGCCACTTTGGTCGCCCTT
GGGGCACTGGCCTTGTACGTCGCGAAGCCCTCCGGCTACGGGAAGCACACGGAGAGCCTG
AAGCCGGCGGCTACCCGCCTGCCAGCCCGCGCCGCCTGGTTCCTGCAGGAGCTGCCTTCC
TTCGCGGTGCCCGCGGGGATCCTCGCCCGGCAGCCCCTCTCCCTCTTCGGGCCACCTGGG
ACGGTACTTCTGGGCCTCTTCTGCGTACATTACTTCCACAGGACATTTGTGTACTCACTG
CTCAATCGAGGGAGGCCTTATCCAGCTATACTCATTCTCAGAGGCACTGCCTTCTGCACT
GGAAATGGAGTCCTTCAAGGCTACTATCTGATTTACTGTGCTGAATACCCTGATGGGTGG
TACACAGACATACGGTTTAGCTTGGGTGTCTTCTTATTTATTTTGGGAATGGGAATAAAC
ATTCATAGTGACTATATATTGCGCCAGCTCAGGAAGCCTGGAGAAATCAGCTACAGGATT
CCACAAGGTGGCTTGTTTACGTATGTTTCTGGAGCCAATTTCCTCGGTGAGATCATTGAA
TGGATCGGCTATGCCCTGGCCACTTGGTCCCTCCCAGCACTTGCATTTGCATTTTTCTCA
CTTTGTTTCCTTGGGCTGCGAGCTTTTCACCACCATAGGTTCTACCTCAAGATGTTTGAG
GACTACCCCAAATCTCGGAAAGCCCTTATTCCATTCATCTTTTAA

# Metabolic_Enzyme_5_GenBank_ID_Gene:
M74047

# Metabolic_Enzyme_5_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_5_Locus:
2p23

# Metabolic_Enzyme_5_SNPs:
rs1042578; rs632148; rs9332975; rs10529926; rs28383085; rs2754530; rs2281546; rs7571644; rs2268796; rs2300701; rs11690596; rs11892064; rs12467911; rs11889731; rs413836; rs11675297; rs519704; rs2300700; rs6543634; rs2300699; rs2268794; rs522638; rs7599086; rs523349; rs2300698; rs2300697; rs12691180; rs2208532; rs6543633; rs12712320; rs13429955; rs4141419; rs7594951; rs17546253; rs765138; rs17011453; rs17011504; rs725631; rs12470143; rs9332964; rs11903331; rs6543632; rs7424544; rs4952220; rs2268797; rs9282858; rs6749019; rs9332965; rs7562326; rs13395648; rs2300702; rs2268799; rs28383036; rs10196388; rs4952197; rs4952221; rs372319; rs28745289; rs6740595; rs28383071; rs12470196; rs17011470; rs28382999; rs9332961; rs6727380; rs28383050; rs11890640; rs28383068; rs28382998; rs28383004; rs12712321; rs479847; rs28383017; rs28383018; rs28383007; rs28745302; rs28745296; rs28383054; rs2886560; rs2366065; rs7422695; rs4952222; rs28745295; rs28383078; rs28383031; rs10207755; rs1988909; rs11690694; rs11692999; rs10204002; rs28383051; rs2300703; rs28383049; rs28745303; rs28383003; rs28383038; rs9332963; rs28745281; rs28383037; rs28383047; rs28383041; rs7602349; rs28383032; rs28383014; rs28745298; rs28745291; rs6736809; rs28383005; rs2208531; rs12712322; rs28745290; rs2366060; rs28383081; rs11690495; rs28383030; rs28383025; rs28383023; rs12995898; rs12463458; rs28383076; rs28383079; rs28745283; rs2366062; rs3731586; rs1884722; rs806645; rs28383091; rs28382994; rs28382988; rs28382987; rs12468405; rs9332966; rs9332967; rs28383084; rs28383082; rs11547686; rs28383087; rs28383089; rs28383083; rs6761746; rs28383088; rs28383086; rs28383039; rs13021367; rs28383008; rs34746513; rs35284547; rs2366063; rs28383043; rs28383048; rs28383067; rs34255370; rs28383063; rs28383022; rs28383021; rs13425265; rs28383012; rs28383055; rs35977260; rs28383052; rs28383046; rs28383034; rs28383000; rs28745293; rs11904357; rs28383015; rs34454544; rs28383074; rs2268795; rs34841992; rs28383065; rs13021313; rs10200753; rs28383057; rs28745284; rs28383059; rs11892634; rs35159589; rs34361388; rs10699850; rs36115939; rs13432637; rs9332962; rs13422722; rs28383080; rs28383064; rs12477492; rs619857; rs28745287; rs34985990; rs10177204; rs6726725; rs17546042; rs28383033; rs11124263; rs28836273; rs2366061; rs28383045; rs2268798; rs28383077; rs34014922; rs13007814; rs28383066; rs28745282; rs28383053; rs28383027; rs28383011; rs28382996; rs10177203; rs28383024; rs35702549; rs28383073; rs11399152; rs34909509; rs11399151; rs28383061; rs493165; rs12994135; rs10587327; rs28383070; rs28745294; rs13432696; rs10542564; rs28383001; rs28383013; rs35847074; rs28383056; rs28383062; rs28383072; rs11421066; rs5830211; rs28383058; rs11682183; rs3831847; rs28383009; rs35741321; rs2224473; rs35752905; rs7590260; rs28383075; rs28745299; rs35208541; rs542070; rs34819358; rs12994686; rs34862482; rs34552434; rs28745285; rs9332960; rs33934330; rs35112319; rs28383029; rs6726572; rs28745300; rs34852406; rs35865269; rs10185314; rs13025727; rs28745292; rs11335627; rs6751111; rs28383040; rs28383028; rs34349298; rs28745297; rs34860585; rs7559265; rs12997007; rs34631603; rs33952006; rs2366064; rs28383044; rs28382997; rs28383035; rs28383016; rs34143326; rs28745286; rs1118795; rs28383026; rs28383060; rs34600093; rs10200758; rs28383006; rs28383069; rs34262589; rs28383042; rs3819844; rs28745288; rs36090156; rs28383010; rs494302; rs28745301; rs2666408; rs28383098; rs17605682; rs28382989; rs34082006; rs28383094; rs28383093; rs28382992; rs28382991; rs28383103; rs28383101; rs28383096; rs28383099; rs28383090; rs28382993; rs3731587; rs28383092; rs28383095; rs28383100; rs28382990; rs28383102; rs28383097; rs34507825; rs11403363; rs28382995; rs11885394; rs11894988; rs12475716; rs12712317; rs12997020; rs12997024; rs1475054; rs2224310; rs3754838; rs383806; rs4443038; rs499362; rs559555; rs599300; rs6543631; rs6732223; rs6760199; rs676033

# Metabolic_Enzyme_5_General_References:
1944596; 1505484; 1522235; 7554313; 8626825; 8768837; 9208814; 9843052; 9745434; 10501358; 10718838; 10999800; 11927504

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5683

# Metabolic_Enzyme_6_Name:
Cytochrome P450 11B1, mitochondrial precursor

# Metabolic_Enzyme_6_Synonyms:
CYPXIB1; P450C11; P-450c11; Steroid 11-beta-hydroxylase

# Metabolic_Enzyme_6_Gene_Name:
CYP11B1

# Metabolic_Enzyme_6_Protein_Sequence:
>Cytochrome P450 11B1, mitochondrial precursor
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPQRPGNRWLRLLQIWREQG
YEDLHLEVHQ
TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY
RQHRGHKCGVFLLNGPEWRFN
RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ
NARGSLTLDVQPSIFHYTIEASNLALFGERLG
LVGHSPSSASLNFLHALEVMFKSTVQL
MFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF
SRPQQYTSIVAELLLN
AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS
ISEHP
QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPA
LFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE
TLTQEDIKMVYSFILR
PSMCPLLTFRAIN

# Metabolic_Enzyme_6_Number_of_Residues:
503

# Metabolic_Enzyme_6_Molecular_Weight:
57530

# Metabolic_Enzyme_6_Theoretical_pI:
9.42

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Metabolic_Enzyme_6_Specific_Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

# Metabolic_Enzyme_6_Pathway:
map00140  C21-Steroid hormone metabolism;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_6_Reaction:
a steroid + reduced adrenal ferredoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00067:p450

# Metabolic_Enzyme_6_Signals:
1-23

# Metabolic_Enzyme_6_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 1.14.15.4

# Metabolic_Enzyme_6_GenBank_ID_Protein:
181333

# Metabolic_Enzyme_6_SwissProt_ID:
C11B1_HUMAN (P15538)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
CYP11B1

# Metabolic_Enzyme_6_Geneatlas_id:
CYP11B1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:2591

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Mitochondrion

# Metabolic_Enzyme_6_Gene_Sequence:
>1512 bp

ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAG
GGCACAGGCAC
TGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAG
CCATGCCCCGGCGTCCAGGCAA
CAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAG
GGTTATGAGGACCTGCACCTGGAAGTACACCAG
ACCTTCCAGGAACTGGGGCCCATTTT
CAGGTACGATTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGC
CGGAGGACGTGGAGA
AGCTGCAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGT
GGCC
TACAGACAACATCGTGGGCACAAATGTGGCGTGTTCTTGCTGAATGGGCCTGAATGGCGC
TTCAAC
CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCT
CCCGATGGTGGATGCAG
TGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGC
AGAACGCCCGGGGGAGCCTGACCCTGGA
CGTCCAGCCCAGCATCTTCCACTACACCATA
GAAGCCAGCAACTTGGCTCTTTTTGGAGAGCGGCTGGGC
CTGGTTGGCCACAGCCCCAG
TTCTGCCAGCCTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCA
CCGTCCAGC
TCATGTTCATGCCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACT
T
TGAGGCCTGGGACTGCATCTTCCAGTACGGCGACAACTGTATCCAGAAAATCTATCAG
GAACTGGCCTTC
AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAA
TGCGGAACTGTCGCCAGATGCCA
TCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCG
TGGACACGACGGTGTTTCCCTTGCTGATGACGCT
CTTTGAGCTGGCTCGGAACCCCAAC
GTGCAGCAGGCCCTGCGCCAGGAGAGCCTGGCCGCCGCAGCCAGC
ATCAGTGAACATCC
CCAGAAGGCAACCACCGAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGC
GGC
TCTACCCTGTGGGTCTGTTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACT
ACCACAT
CCCAGCTGGGACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCC
GCCTTGTTCCCGAGGCCT
GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTC
CGGCAGGAACTTCTACCACGTGCCCTTTG
GCTTTGGCATGCGCCAGTGCCTTGGGCGGC
GCCTGGCAGAGGCAGAGATGCTGCTGCTGCTGCACCATGT
GCTGAAACACCTCCAGGTG
GAGACACTAACCCAAGAGGACATAAAGATGGTCTACAGCTTCATATTGAGG
CCCAGCAT
GTGCCCCCTCCTCACCTTCAGAGCCATCAACTAA

# Metabolic_Enzyme_6_GenBank_ID_Gene:
M32879

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_6_Locus:
8q21

# Metabolic_Enzyme_6_SNPs:
rs4541; rs4534; rs5288; rs5294; rs6405; rs34620645; rs6410; rs5283; rs5290; rs6403; rs6419; rs34570566; rs5316; rs5284; rs5299; rs5301; rs7003319; rs5304; rs1134096; rs5303; rs1134095; rs5017238; rs5297; rs4736312; rs5300; rs3802229; rs6389; rs9657021; rs4310186; rs6388; rs7822986; rs6471570; rs6387; rs4535; rs4736315; rs10956991; rs5295; rs6393; rs7814006; rs7814020; rs7818826; rs4609179; rs7818953; rs11775687; rs6390; rs6398; rs10105643; rs6400; rs6392; rs12674916; rs7833415; rs6411; rs6391; rs12542799; rs6402; rs6395; rs6422; rs6409; rs5280; rs4736346; rs10093618; rs4736311; rs4471016; rs4313136; rs5292; rs28934586; rs5287; rs5282; rs4998901; rs5291; rs4998896; rs6407; rs4998898; rs4998902; rs4998900; rs4998899; rs4998903; rs4998897; rs9657022; rs5296; rs4998895; rs1137481; rs1137484; rs5302; rs35673190; rs5017237; rs1137480; rs1137485; rs12543598; rs5298; rs34274727; rs1137488; rs5017240; rs5027479; rs1137486; rs1137483; rs5027480; rs5017239; rs1137487; rs5027478; rs4998894; rs9657020; rs4999335; rs4236887; rs5286; rs13250178; rs4999334; rs35378570; rs28551743; rs36004897; rs5895733; rs34698173; rs12114482; rs28418310; rs10098023; rs4464947; rs4548164; rs4581033; rs4736308; rs4736309; rs4736310; rs4736349; rs4736350; rs6995180; rs7005638; rs7016088; rs7016594

# Metabolic_Enzyme_6_General_References:
2592361; 2401360; 7903314; 3499608; 1741400; 2022736; 9302260; 10599751; 10391209; 10391210

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5972

# Metabolic_Enzyme_7_Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1

# Metabolic_Enzyme_7_Synonyms:
Steroid 5- alpha-reductase 1; SR type 1; S5AR

# Metabolic_Enzyme_7_Gene_Name:
SRD5A1

# Metabolic_Enzyme_7_Protein_Sequence:
>3oxo5alphasteroid 4dehydrogenase 1
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF

# Metabolic_Enzyme_7_Number_of_Residues:
259

# Metabolic_Enzyme_7_Molecular_Weight:
29459

# Metabolic_Enzyme_7_Theoretical_pI:
9.07

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  cell
Component:  membrane
Component:  intrinsic to membrane
Component:  integral to membrane

# Metabolic_Enzyme_7_General_Function:
Not Available

# Metabolic_Enzyme_7_Specific_Function:
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology

# Metabolic_Enzyme_7_Pathway:
map00120  Bile acid biosynthesis;
 map00150  Androgen and estrogen metabolism

# Metabolic_Enzyme_7_Reaction:
a 3-oxo-5alpha-steroid + acceptor = a 3-oxo-delta4-steroid + reduced acceptor

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF02544:Steroid_dh

# Metabolic_Enzyme_7_Signals:
1-24

# Metabolic_Enzyme_7_Transmembrane_Regions:
111-131
151-171
209-229

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 1.3.99.5

# Metabolic_Enzyme_7_GenBank_ID_Protein:
177767

# Metabolic_Enzyme_7_SwissProt_ID:
S5A1_HUMAN (P18405)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
SRD5A1

# Metabolic_Enzyme_7_Geneatlas_id:
SRD5A1

# Metabolic_Enzyme_7_hgnc_id:
HGNC:11284

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome; microsomal membrane; multi-pass membrane protein

# Metabolic_Enzyme_7_Gene_Sequence:
>780 bp
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG
TGCGCCGTGGGCTGCGCGGTCTTCGCGCGGAATCGTCAGACGAACTCAGTGTACGGCCGC
CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC
AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA
ATTTACCCGTTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCATGTACAATGGCG
ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG
TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACA
GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT
ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT
GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT
TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC
CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA


# Metabolic_Enzyme_7_GenBank_ID_Gene:
M32313

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:5

# Metabolic_Enzyme_7_Locus:
5p15

# Metabolic_Enzyme_7_SNPs:
rs8192186; rs523854; rs3822430; rs3736316; rs3297; rs8192257; rs13974; rs1042150; rs8192254; rs8192256; rs471604; rs1896670; rs693651; rs500182; rs531241; rs248805; rs566202; rs477755; rs6884552; rs494958; rs7707559; rs500058; rs8192139; rs527786; rs508415; rs248797; rs181807; rs193744; rs6872996; rs248803; rs482121; rs248806; rs501999; rs568509; rs7720479; rs1560149; rs3733773; rs1651075; rs2677933; rs7706809; rs11134173; rs540212; rs187470; rs10065299; rs11738248; rs472402; rs824809; rs6883294; rs524817; rs2307270; rs3797177; rs166050; rs4702374; rs3797179; rs477930; rs8192189; rs8192180; rs4702379; rs824810; rs8192250; rs2307268; rs6874555; rs8192131; rs8192228; rs1691052; rs7730680; rs248796; rs533251; rs484973; rs4702375; rs8192223; rs8192203; rs555257; rs7732907; rs248794; rs7707877; rs2434524; rs248799; rs10060745; rs8192178; rs494803; rs8192181; rs8192207; rs8192147; rs8192198; rs8192130; rs248798; rs168713; rs8192135; rs535981; rs8192165; rs248800; rs4702378; rs8192209; rs10055803; rs4702381; rs8192133; rs8192179; rs7714182; rs8192249; rs8192166; rs485614; rs7727273; rs248807; rs8192145; rs533109; rs8192160; rs8192213; rs8192193; rs8192224; rs530370; rs1651074; rs8192195; rs562461; rs248801; rs8192215; rs2677932; rs8192222; rs8192231; rs8192206; rs8192246; rs8192148; rs8192233; rs4702380; rs7711978; rs8192219; rs8192152; rs8192235; rs8192183; rs8192141; rs10050691; rs8192164; rs4702382; rs8192134; rs8192241; rs8192192; rs521293; rs8192232; rs8192212; rs8192154; rs8192177; rs8192242; rs8192144; rs7736897; rs8192214; rs8192142; rs3797178; rs2677947; rs8192149; rs8192210; rs8192227; rs8192184; rs8192194; rs248795; rs473262; rs824811; rs8192190; rs8192221; rs8192216; rs8192247; rs8192202; rs8192191; rs8192168; rs8192245; rs8192204; rs8192138; rs8192218; rs8192158; rs8192200; rs8192163; rs8192226; rs8192182; rs8192243; rs8192236; rs39848; rs8192208; rs1802949; rs3296; rs8192253; rs8192255; rs1802278; rs13185837; rs34666637; rs34554906; rs35245174; rs11308252; rs8192136; rs16877740; rs8192199; rs3996846; rs187469; rs8192238; rs34601393; rs524971; rs11955270; rs8192211; rs36004068; rs8192155; rs8192176; rs556181; rs33996513; rs34319431; rs13171416; rs6875453; rs183133; rs187260; rs8192156; rs8192217; rs8192167; rs11402127; rs8192150; rs8192159; rs8192185; rs8192201; rs36070666; rs173588; rs11343625; rs523584; rs2434527; rs11454295; rs8192244; rs11743462; rs8192248; rs8192162; rs8192197; rs8192146; rs248804; rs35510604; rs35595453; rs8192220; rs16877752; rs8192188; rs8192225; rs11134174; rs8192237; rs33958486; rs8192251; rs34459395; rs10044539; rs2677946; rs11357349; rs35377021; rs8192161; rs34248138; rs8192132; rs8192234; rs8192205; rs28567857; rs8192137; rs8192157; rs185092; rs8192230; rs34394317; rs35634286; rs13164181; rs11402128; rs8192239; rs472358; rs1799606; rs1651073; rs8192229; rs8192151; rs8192143; rs34105852; rs34173021; rs28393089; rs4395608; rs248802; rs16877731; rs8192240; rs8192140; rs11434052; rs7704431; rs496839; rs8192196; rs8192173; rs562705; rs34914467; rs181806; rs8192252; rs8192153; rs10037161; rs10512872; rs11948470; rs11951218; rs12716180; rs12716181; rs13166363; rs1651071; rs166049; rs16877779; rs1691053; rs193743; rs2288447; rs2434525; rs2677931; rs30434; rs39847; rs4133452; rs4702373; rs508491; rs518673; rs531290; rs571550; rs6874005; rs8192120; rs8192123; rs8192124

# Metabolic_Enzyme_7_General_References:
2339109; 1686016; 10931946; 11678334

# Metabolic_Enzyme_7_References:
Not Available

# Macromolecular_Interacting_Partner_1_ID:
7197

# Macromolecular_Interacting_Partner_1_Name:
Corticotropin-lipotropin precursor

# Macromolecular_Interacting_Partner_1_Synonyms:
Pro-opiomelanocortin; POMC[Contains: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin]

# Macromolecular_Interacting_Partner_1_Gene_Name:
POMC

# Macromolecular_Interacting_Partner_1_Protein_Sequence:
>Corticotropinlipotropin precursor
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE

# Macromolecular_Interacting_Partner_1_Number_of_Residues:
267

# Macromolecular_Interacting_Partner_1_Molecular_Weight:
29424

# Macromolecular_Interacting_Partner_1_Theoretical_pI:
7.75

# Macromolecular_Interacting_Partner_1_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_1_General_Function:
Not Available

# Macromolecular_Interacting_Partner_1_Specific_Function:
Beta-endorphin and Met-enkephalin are endogenous opiates

# Macromolecular_Interacting_Partner_1_Pathway:
Not Available

# Macromolecular_Interacting_Partner_1_Reaction:
Not Available

# Macromolecular_Interacting_Partner_1_Pfam_Domain_Function:
PF00976:ACTH_domain;
PF08384:NPP;
PF08035:Op_neuropeptide

# Macromolecular_Interacting_Partner_1_Signals:
1-26

# Macromolecular_Interacting_Partner_1_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_1_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_1_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_1_GenBank_ID_Protein:
190188

# Macromolecular_Interacting_Partner_1_SwissProt_ID:
COLI_HUMAN (P01189)

# Macromolecular_Interacting_Partner_1_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_1_Genecard_id:
POMC

# Macromolecular_Interacting_Partner_1_Geneatlas_id:
POMC

# Macromolecular_Interacting_Partner_1_hgnc_id:
HGNC:9201

# Macromolecular_Interacting_Partner_1_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_1_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_1_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_1_Gene_Sequence:
>789 bp
TGCAGCCGCTCGGGGGCCCTGTTGCTGGCCTTGCTGCTTCAGGCCTCCATGGAAGTGCGT
GGCTGGTGCCTGGAGAGCAGCCAGTGTCAGGACCTCACCACGGAAAGCAACCTGCTGGAG
TGCATCCGGGCCTGCAAGCCCGACCTCTCGGCCGAGACTCCCATGTTCCCGGGAAATGGC
GACGAGCAGCCTCTGACCGAGAACCCCCGGAAGTACGTCATGGGCCACTTCCGCTGGGAC
CGATTCGGCCGCCGCAACAGCAGCAGCAGCGGCAGCAGCGGCGCAGGGCAGAAGCGCGAG
GACGTCTCAGCGGGCGAAGACTGCGGCCCGCTGCCTGAGGGCGGCCCCGAGCCCCGCAGC
GATGGTGCCAAGCCGGGCCCGCGCGAGGGCAAGCGCTCCTACTCCATGGAGCACTTCCGC
TGGGGCAAGCCGGTGGGCAAGAAGCGGCGCCCAGTGAAGGTGTACCCTAACGGCGCCGAG
GACGAGTCGGCCGAGGCCTTCCCCCTGGAGTTCAAGAGGGAGCTGACTGGCCAGCGACTC
CGGGAGGGAGATGGCCCCGACGGCCCTGCCGATGACGGCGCAGGGGCCCAGGCCGACCTG
GAGCACAGCCTGCTGGTGGCGGCCGAGAAGAAGGACGAGGGCCCCTACAGGATGGAGCAC
TTCCGCTGGGGCAGCCCGCCCAAGGACAAGCGCTACGGCGGTTTCATGACCTCCGAGAAG
AGCCAGACGCCCCTGGTGACGCTGTTCAAAAACGCCATCATCAAGAACGCCTACAAGAAG
GGCGAGTGA

# Macromolecular_Interacting_Partner_1_GenBank_ID_Gene:
M38297

# Macromolecular_Interacting_Partner_1_Chromosome_Location:
Chromosome:2

# Macromolecular_Interacting_Partner_1_Locus:
2p23.3

# Macromolecular_Interacting_Partner_1_SNPs:
rs28932472; rs8192606; rs28932471; rs35254395; rs8192605; rs28930368; rs2071345; rs34650613; rs1042571; rs11679531; rs6713532; rs7565877; rs6713396; rs12473543; rs6756695; rs6545975; rs6756566; rs28932474; rs28932476; rs28932475; rs28932473; rs10654394; rs28932470; rs3039380; rs35411223; rs35023083; rs33950052; rs7591899; rs15461; rs2071344; rs13388660; rs9973478; rs11353932; rs13404336; rs7565427; rs34619618; rs8192607; rs35639116; rs34526166; rs10188864; rs10195561; rs11892647; rs12472851; rs13418937; rs17046887; rs17046891; rs1866146; rs2071343; rs2118404; rs2164808; rs3769671; rs3795955; rs3820935; rs6545976; rs6719226; rs6734859; rs7589318; rs7605927; rs934778

# Macromolecular_Interacting_Partner_1_General_References:
6274691; 6299668; 6314261; 3606677; 6254047; 6945581; 6267033; 6272808; 4352834; 4334191; 4338630; 4347148; 1264228; 195688; 2424570; 2839146; 7828531; 9768693; 10193875; 11244459

# Macromolecular_Interacting_Partner_1_References:
10409573; 10469007; 10599726; 10634362

# Macromolecular_Interacting_Partner_2_ID:
7546

# Macromolecular_Interacting_Partner_2_Name:
Prolactin precursor

# Macromolecular_Interacting_Partner_2_Synonyms:
PRL

# Macromolecular_Interacting_Partner_2_Gene_Name:
PRL

# Macromolecular_Interacting_Partner_2_Protein_Sequence:
>Prolactin precursor
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC

# Macromolecular_Interacting_Partner_2_Number_of_Residues:
227

# Macromolecular_Interacting_Partner_2_Molecular_Weight:
25876

# Macromolecular_Interacting_Partner_2_Theoretical_pI:
6.99

# Macromolecular_Interacting_Partner_2_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  Not Available
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_2_General_Function:
Not Available

# Macromolecular_Interacting_Partner_2_Specific_Function:
Prolactin acts primarily on the mammary gland by promoting lactation

# Macromolecular_Interacting_Partner_2_Pathway:
Not Available

# Macromolecular_Interacting_Partner_2_Reaction:
Not Available

# Macromolecular_Interacting_Partner_2_Pfam_Domain_Function:
PF00103:Hormone_1

# Macromolecular_Interacting_Partner_2_Signals:
1-28

# Macromolecular_Interacting_Partner_2_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_2_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_2_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_2_GenBank_ID_Protein:
34211

# Macromolecular_Interacting_Partner_2_SwissProt_ID:
PRL_HUMAN (P01236)

# Macromolecular_Interacting_Partner_2_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_2_Genecard_id:
PRL

# Macromolecular_Interacting_Partner_2_Geneatlas_id:
PRL

# Macromolecular_Interacting_Partner_2_hgnc_id:
HGNC:9445

# Macromolecular_Interacting_Partner_2_PDB_ID:
1RW5

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_2_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_2_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_2_Gene_Sequence:
>684 bp
ATGAACATCAAAGGATCGCCATGGAAAGGGTCCCTCCTGCTGCTGCTGGTGTCAAACCTG
CTGCTGTGCCAGAGCGTGGCCCCCTTGCCCATCTGTCCCGGCGGGGCTGCCCGATGCCAG
GTGACCCTTCGAGACCTGTTTGACCGCGCCGTCGTCCTGTCCCACTACATCCATAACCTC
TCCTCAGAAATGTTCAGCGAATTCGATAAACGGTATACCCATGGCCGGGGGTTCATTACC
AAGGCCATCAACAGCTGCCACACTTCTTCCCTTGCCACCCCCGAAGACAAGGAGCAAGCC
CAACAGATGAATCAAAAAGACTTTCTGAGCCTGATAGTCAGCATATTGCGATCCTGGAAT
GAGCCTCTGTATCATCTGGTCACGGAAGTACGTGGTATGCAAGAAGCCCCGGAGGCTATC
CTATCCAAAGCTGTAGAGATTGAGGAGCAAACCAAACGGCTTCTAGAGGGCATGGAGCTG
ATAGTCAGCCAGGTTCATCCTGAAACCAAAGAAAATGAGATCTACCCTGTCTGGTCGGGA
CTTCCATCCCTGCAGATGGCTGATGAAGAGTCTCGCCTTTCTGCTTATTATAACCTGCTC
CACTGCCTACGCAGGGATTCACATAAAATCGACAATTATCTCAAGCTCCTGAAGTGCCGA
ATCATCCACAACAACAACTGCTAA

# Macromolecular_Interacting_Partner_2_GenBank_ID_Gene:
V00566

# Macromolecular_Interacting_Partner_2_Chromosome_Location:
Chromosome:6

# Macromolecular_Interacting_Partner_2_Locus:
6p22.2-p21.3

# Macromolecular_Interacting_Partner_2_SNPs:
Not Available

# Macromolecular_Interacting_Partner_2_General_References:
6260780; 6325171; 2050267; 6146607; 9266104; 925136; 1126929

# Macromolecular_Interacting_Partner_2_References:
10362098; 10469684; 10530323; 10902292

# Macromolecular_Interacting_Partner_3_ID:
7549

# Macromolecular_Interacting_Partner_3_Name:
Insulin precursor [Contains: Insulin B chain; Insulin A chain]

# Macromolecular_Interacting_Partner_3_Synonyms:
Not Available

# Macromolecular_Interacting_Partner_3_Gene_Name:
INS

# Macromolecular_Interacting_Partner_3_Protein_Sequence:
>Insulin precursor Contains: Insulin B chain; Insulin A chain
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

# Macromolecular_Interacting_Partner_3_Number_of_Residues:
110

# Macromolecular_Interacting_Partner_3_Molecular_Weight:
11981

# Macromolecular_Interacting_Partner_3_Theoretical_pI:
5.01

# Macromolecular_Interacting_Partner_3_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_3_General_Function:
Not Available

# Macromolecular_Interacting_Partner_3_Specific_Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

# Macromolecular_Interacting_Partner_3_Pathway:
Not Available

# Macromolecular_Interacting_Partner_3_Reaction:
Not Available

# Macromolecular_Interacting_Partner_3_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_3_Signals:
1-24

# Macromolecular_Interacting_Partner_3_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_3_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_3_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_3_GenBank_ID_Protein:
758088

# Macromolecular_Interacting_Partner_3_SwissProt_ID:
INS_HUMAN (P01308)

# Macromolecular_Interacting_Partner_3_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_3_Genecard_id:
INS

# Macromolecular_Interacting_Partner_3_Geneatlas_id:
INS

# Macromolecular_Interacting_Partner_3_hgnc_id:
HGNC:6081

# Macromolecular_Interacting_Partner_3_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_3_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_3_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_3_Gene_Sequence:
>333 bp
ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGAC
CCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTAC
CTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGAC
CTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTG
GCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGC
TCCCTCTACCAGCTGGAGAACTACTGCAACTAG

# Macromolecular_Interacting_Partner_3_GenBank_ID_Gene:
V00565

# Macromolecular_Interacting_Partner_3_Chromosome_Location:
Chromosome:11

# Macromolecular_Interacting_Partner_3_Locus:
11p15.5

# Macromolecular_Interacting_Partner_3_SNPs:
rs3842744; rs689; rs3842753; rs3842740; rs3842752; rs9282755; rs9282754; rs3842741; rs5505; rs3842748; rs5507; rs5506; rs3842746; rs3842750; rs3842749; rs3842755; rs3842754; rs3842757; rs3842738; rs3842756; rs3842730; rs17879158; rs3842763; rs3842737; rs3842732; rs3842766; rs3842731; rs3842729; rs3842733; rs3842728; rs3842762; rs3842759; rs3842734; rs3842765; rs3842739; rs3842764; rs3842760; rs3842758; rs3842736; rs28933985; rs41301451; rs13306444; rs11557614; rs11557609; rs11557608; rs11557616; rs11557610; rs11564720; rs11557607; rs11557606; rs11557615; rs11557611; rs41313495; rs11557605; rs13306443; rs41275200; rs7946759; rs41275198; rs35068908; rs3842747; rs13306442; rs3842735; rs12791622; rs11564719; rs34765616; rs28494588; rs12292082; rs7933329; rs35811949; rs17884578; rs7938907; rs35766658; rs5789245; rs35599874; rs7933337; rs35766025; rs17885694; rs10840447; rs10840452; rs11564716; rs11564717; rs12790603; rs2000993; rs2070762; rs28934580; rs28934581; rs34510659; rs36097848; rs3842768; rs3842769; rs3842770; rs3842775; rs4072824; rs4074905; rs4320932; rs6356; rs6357; rs7110099; rs7482510; rs7924316; rs7925924; rs7950050

# Macromolecular_Interacting_Partner_3_General_References:
6243748; 6248962; 503234; 6927840; 8358440; 5101771; 5560404; 4443293; 4803504; 4698555; 4698553; 6312455; 6424111; 3470784; 3537011; 2196279; 4019786; 1601997; 2271664; 2036420; 1646635; 1433291; 8421693; 9235985

# Macromolecular_Interacting_Partner_3_References:
10645259; 10731533; 10902292; 10965205

# Macromolecular_Interacting_Partner_4_ID:
6946

# Macromolecular_Interacting_Partner_4_Name:
Sex hormone-binding globulin precursor

# Macromolecular_Interacting_Partner_4_Synonyms:
SHBG; Sex steroid-binding protein; SBP; Testis-specific androgen-binding protein; ABP; Testosterone-estrogen-binding globulin; Testosterone-estradiol- binding globulin; TeBG

# Macromolecular_Interacting_Partner_4_Gene_Name:
SHBG

# Macromolecular_Interacting_Partner_4_Protein_Sequence:
>Sex hormonebinding globulin precursor
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMT
FDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGA
GPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPAS
NLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDI
PQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPL
VLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTS
FCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

# Macromolecular_Interacting_Partner_4_Number_of_Residues:
402

# Macromolecular_Interacting_Partner_4_Molecular_Weight:
43780

# Macromolecular_Interacting_Partner_4_Theoretical_pI:
6.70

# Macromolecular_Interacting_Partner_4_GO_Classification:
Not Available

# Macromolecular_Interacting_Partner_4_General_Function:
Not Available

# Macromolecular_Interacting_Partner_4_Specific_Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration

# Macromolecular_Interacting_Partner_4_Pathway:
Not Available

# Macromolecular_Interacting_Partner_4_Reaction:
Not Available

# Macromolecular_Interacting_Partner_4_Pfam_Domain_Function:
PF00054:Laminin_G_1

# Macromolecular_Interacting_Partner_4_Signals:
1-29

# Macromolecular_Interacting_Partner_4_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_4_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_4_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_4_GenBank_ID_Protein:
296673

# Macromolecular_Interacting_Partner_4_SwissProt_ID:
SHBG_HUMAN (P04278)

# Macromolecular_Interacting_Partner_4_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_4_Genecard_id:
SHBG

# Macromolecular_Interacting_Partner_4_Geneatlas_id:
SHBG

# Macromolecular_Interacting_Partner_4_hgnc_id:
HGNC:10839

# Macromolecular_Interacting_Partner_4_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_4_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_4_Subcellular_Location:
Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity)

# Macromolecular_Interacting_Partner_4_Gene_Sequence:
>1209 bp
ATGGAGAGCAGAGGCCCACTGGCTACCTCGCGCCTGCTGCTGTTGCTGCTGTTGCTACTA
CTGCGTCACACCCGCCAGGGATGGGCCCTGAGACCTGTTCTCCCCACCCAGAGTGCCCAC
GACCCTCCGGCTGTCCACCTCAGCAATGGCCCAGGACAAGAGCCTATCGCTGTCATGACC
TTTGACCTCACCAAGATCACAAAAACCTCCTCCTCCTTTGAGGTTCGAACCTGGGACCCA
GAGGGAGTGATTTTTTATGGGGATACCAACCCTAAGGATGACTGGTTTATGCTGGGACTT
CGAGACGGCAGGCCTGAGATCCAACTGCACAATCACTGGGCCCAGCTTACGGTGGGTGCT
GGACCACGGCTGGATGATGGGAGATGGCACCAGGTGGAAGTCAAGATGGAGGGGGACTCT
GTGCTGCTGGAGGTGGATGGGGAGGAGGTGCTGCGCCTGAGACAGGTCTCTGGGCCCCTG
ACCAGCAAACGCCATCCCATCATGAGGATTGCGCTTGGGGGGCTGCTCTTCCCCGCTTCC
AACCTTCGGTTGCCGCTGGTTCCTGCCCTGGATGGCTGCCTGCGCCGGGATTCCTGGCTG
GACAAACAGGCCGAGATCTCAGCATCTGCCCCCACTAGCCTCAGAAGCTGTGATGTAGAA
TCAAATCCCGGGATATTTCTCCCTCCAGGGACTCAGGCAGAATTCAATCTCCGAGACATT
CCCCAGCCTCATGCAGAGCCCTGGGCCTTCTCTTTGGACCTGGGACTCAAGCAGGCAGCA
GGCTCAGGCCACCTCCTTGCTCTTGGGACACCAGAGAACCCATCTTGGCTCAGTCTCCAC
CTCCAAGATCAAAAGGTGGTGTTGTCTTCTGGGTCGGGGCCAGGGCTGGATCTGCCCCTG
GTCTTGGGACTCCCTCTTCAGCTGAAGCTGAGTATGTCCAGGGTGGTCTTGAGCCAAGGG
TCGAAGATGAAGGCCCTTGCCCTGCCTCCCTTAGGCCTGGCTCCCCTCCTTAACCTCTGG
GCCAAGCCTCAAGGGCGTCTCTTCCTGGGGGCTTTACCAGGAGAAGACTCTTCCACCTCT
TTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAAC
AGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCCAGGCAATGGCACTGACGCT
TCCCATTAA

# Macromolecular_Interacting_Partner_4_GenBank_ID_Gene:
X16349

# Macromolecular_Interacting_Partner_4_Chromosome_Location:
Chromosome:17

# Macromolecular_Interacting_Partner_4_Locus:
17p13-p12

# Macromolecular_Interacting_Partner_4_SNPs:
rs6260; rs6258; rs9282845; rs6259; rs6261; rs4987212; rs9282846; rs6257; rs9913778; rs858517; rs1799941; rs858516; rs35167070; rs34865989; rs34420533; rs35338190; rs3760213; rs8065089; rs5030659; rs13894; rs1641536; rs1641537; rs1641544; rs1642800; rs2543553; rs2955617; rs34780532; rs727428; rs858520; rs858521; rs9898876

# Macromolecular_Interacting_Partner_4_General_References:
2587256; 2608061; 3569533; 2956126; 2956125; 3702459; 3542030; 1400872; 10675319; 12065592; 7714097; 10391209

# Macromolecular_Interacting_Partner_4_References:
10362098; 10624701; 10868692; 10951152

# Macromolecular_Interacting_Partner_5_ID:
6332

# Macromolecular_Interacting_Partner_5_Name:
Cytochrome P450 17A1

# Macromolecular_Interacting_Partner_5_Synonyms:
CYPXVII; P450-C17; P450c17; Steroid 17-alpha-monooxygenase; Steroid 17-alpha-hydroxylase/17,20 lyase

# Macromolecular_Interacting_Partner_5_Gene_Name:
CYP17A1

# Macromolecular_Interacting_Partner_5_Protein_Sequence:
>Cytochrome P450 17A1
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGT
KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGA
HWQLHRRLAMATFALFKDGDQ
KLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV
ISLICFNTSYKNGDPELNVIQNYNEGIIDNLS
KDSLVDLVPWLKIFPNKTLEKLKSHVK
IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP
DQDSELLSDNHILTTI
GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL
LLLEA
TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE
RFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP
SLEGIPKVVFLIDSFK
VKIKVRQAWREAQAEGST

# Macromolecular_Interacting_Partner_5_Number_of_Residues:
508

# Macromolecular_Interacting_Partner_5_Molecular_Weight:
57371

# Macromolecular_Interacting_Partner_5_Theoretical_pI:
8.87

# Macromolecular_Interacting_Partner_5_GO_Classification:
>>>
Function:  tetrapyrrole binding
Function:  heme binding
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  transition metal ion binding
Function:  iron ion binding
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  monooxygenase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Macromolecular_Interacting_Partner_5_General_Function:
Secondary metabolites biosynthesis, transport and catabolism

# Macromolecular_Interacting_Partner_5_Specific_Function:
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty

# Macromolecular_Interacting_Partner_5_Pathway:
map00140  C21-Steroid hormone metabolism

# Macromolecular_Interacting_Partner_5_Reaction:
a steroid + AH2 + O2 = a 17alpha-hydroxysteroid + A + H2O

# Macromolecular_Interacting_Partner_5_Pfam_Domain_Function:
PF00067:p450

# Macromolecular_Interacting_Partner_5_Signals:
1-24

# Macromolecular_Interacting_Partner_5_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_5_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_5_EC_Link:
EC 1.14.99.9

# Macromolecular_Interacting_Partner_5_GenBank_ID_Protein:
181342

# Macromolecular_Interacting_Partner_5_SwissProt_ID:
CP17A_HUMAN (P05093)

# Macromolecular_Interacting_Partner_5_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_5_Genecard_id:
CYP17A1

# Macromolecular_Interacting_Partner_5_Geneatlas_id:
CYP17A1

# Macromolecular_Interacting_Partner_5_hgnc_id:
HGNC:2593

# Macromolecular_Interacting_Partner_5_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_5_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_5_Subcellular_Location:
Not Available

# Macromolecular_Interacting_Partner_5_Gene_Sequence:
>1527 bp

ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAG
AAGGTGCCCTG
GTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCC
TGCCATTCCTCCCCAGACATGG
CCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAA
TATGGCCCCATCTATTCTGTTCGTATGGGCACC
AAGACTACAGTGATTGTCGGCCACCA
CCAGCTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCT
CTGGGCGGCCTCAAA
TGGCAACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTC
TGGC
GCACACTGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGC
GATCAG
AAGCTGGAGAAGATCATTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGC
CACCCACAACGGACAGT
CCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATG
TCATCTCCTTGATCTGCTTCAATACCTC
CTACAAGAATGGGGACCCTGAGTTGAATGTC
ATACAGAATTACAATGAAGGCATCATAGACAACCTGAGC
AAAGACAGCCTGGTGGACCT
AGTCCCCTGGTTGAAGATTTTCCCCAACAAAACCCTGGAAAAATTAAAGA
GCCATGTTA
AAATACGAAATGATCTGCTGAATAAAATACTTGAAAATTACAAGGAGAAATTCCGGAGTG
A
CTCTATCACCAACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGC
AATGCTGGCCCA
GATCAAGATTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCAT
AGGGGACATCTTTGGGGCTGGCG
TGGAGACCACCACCTCTGTGGTTAAATGGACCCTGG
CCTTCCTGCTGCACAATCCTCAGGTGAAGAAGAA
GCTCTACGAGGAGATTGACCAGAAT
GTGGGTTTCAGCCGCACACCAACTATCAGTGACCGTAACCGTCTC
CTCCTGCTGGAGGC
CACCATCCGAGAGGTGCTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACA
AGG
CCAACGTTGACTCCAGCATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCA
ATCTGTG
GGCGCTGCATCACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCT
GAGCGTTTCTTGAATCCA
GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCC
CTTCGGAGCAGGACCTCGCTCCTGTATAG
GTGAGATCCTGGCCCGCCAGGAGCTCTTCC
TCATCATGGCCTGGCTGCTGCAGAGGTTCGACCTGGAGGT
GCCAGATGATGGGCAGCTG
CCCTCCCTGGAAGGCATCCCCAAGGTGGTCTTTCTGATCGACTCTTTCAAA
GTGAAGAT
CAAGGTGCGCCAGGCCTGGAGGGAAGCCCAGGCTGAGGGTAGCACCTAA

# Macromolecular_Interacting_Partner_5_GenBank_ID_Gene:
M14564

# Macromolecular_Interacting_Partner_5_Chromosome_Location:
Chromosome:10

# Macromolecular_Interacting_Partner_5_Locus:
10q24.3

# Macromolecular_Interacting_Partner_5_SNPs:
rs762563; rs6163; rs6162; rs1042386; rs6164; rs743572; rs10883783; rs4919687; rs3781286; rs10786712; rs3781287; rs743575; rs1004467; rs4919686; rs17115100; rs3824755; rs284847; rs755443; rs17115104; rs3740397; rs284849; rs3020724; rs12254149; rs17855149; rs3211406; rs17115125; rs3020717; rs34343941; rs3020712; rs34132012; rs3020723; rs35403742; rs3020714; rs3020715; rs34431726; rs284848; rs3020719; rs3020721; rs284850; rs34983874; rs35538238; rs35144627; rs34713150; rs35165247; rs2911432; rs7922856; rs12219555; rs35745115; rs3020718; rs35115800; rs34846786; rs2911431; rs11191413; rs3020711; rs3020720; rs34485280; rs34620611; rs3020713; rs3020722; rs11191412; rs3890077; rs11191411; rs12775422; rs11191410; rs34005085; rs10509762; rs10883782; rs11191406; rs11191416; rs12242445; rs17115144; rs17115149; rs2486758; rs4919682; rs4919683; rs4919685; rs619824; rs7082755; rs7089422

# Macromolecular_Interacting_Partner_5_General_References:
3025870; 3500022; 3274893; 1964490; 2843762; 10406467; 2808364; 1714904; 1515452; 1740503; 8396144; 8245018; 8345056; 8027220; 8550762; 10720067; 11549685; 11836339; 12466376

# Macromolecular_Interacting_Partner_5_References:
15703266; 15711029

# Macromolecular_Interacting_Partner_6_ID:
6947

# Macromolecular_Interacting_Partner_6_Name:
Androgen receptor

# Macromolecular_Interacting_Partner_6_Synonyms:
Dihydrotestosterone receptor

# Macromolecular_Interacting_Partner_6_Gene_Name:
AR

# Macromolecular_Interacting_Partner_6_Protein_Sequence:
>Androgen receptor
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQ
QQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSA
LECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLK
DILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKA
VSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKS
TEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSR
DYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGP
GSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPY
GYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLE
TARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRND
CTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLT
VSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRM
YSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDR
IIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIIS
VQVPKILSGKVKPIYFHTQ

# Macromolecular_Interacting_Partner_6_Number_of_Residues:
919

# Macromolecular_Interacting_Partner_6_Molecular_Weight:
98990

# Macromolecular_Interacting_Partner_6_Theoretical_pI:
6.38

# Macromolecular_Interacting_Partner_6_GO_Classification:
>>>
Function:  transcription factor activity
Function:  steroid binding
Function:  signal transducer activity
Function:  receptor activity
Function:  ligand-dependent nuclear receptor activity
Function:  steroid hormone receptor activity
Function:  androgen receptor activity
Function:  binding
Function:  nucleic acid binding
Function:  DNA binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of physiological process
Process:  regulation of metabolism
Process:  regulation of cellular metabolism
Process:  regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  regulation of transcription
Process:  regulation of transcription, DNA-dependent
 ||
>>>
Component:  organelle
Component:  membrane-bound organelle
Component:  intracellular membrane-bound organelle
Component:  nucleus

# Macromolecular_Interacting_Partner_6_General_Function:
Not Available

# Macromolecular_Interacting_Partner_6_Specific_Function:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Activated, but not phosphorylated, by HIPK3

# Macromolecular_Interacting_Partner_6_Pathway:
Not Available

# Macromolecular_Interacting_Partner_6_Reaction:
Not Available

# Macromolecular_Interacting_Partner_6_Pfam_Domain_Function:
PF02166:Androgen_recep;
PF00104:Hormone_recep;
PF00105:zf-C4

# Macromolecular_Interacting_Partner_6_Signals:
None

# Macromolecular_Interacting_Partner_6_Transmembrane_Regions:
None

# Macromolecular_Interacting_Partner_6_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_6_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_6_GenBank_ID_Protein:
178628

# Macromolecular_Interacting_Partner_6_SwissProt_ID:
ANDR_HUMAN (P10275)

# Macromolecular_Interacting_Partner_6_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_6_Genecard_id:
AR

# Macromolecular_Interacting_Partner_6_Geneatlas_id:
AR

# Macromolecular_Interacting_Partner_6_hgnc_id:
HGNC:644

# Macromolecular_Interacting_Partner_6_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_6_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_6_Subcellular_Location:
Nucleus

# Macromolecular_Interacting_Partner_6_Gene_Sequence:
>2760 bp
ATGGAAGTGCAGTTAGGGCTGGGAAGGGTCTACCCTCGGCCGCCGTCCAAGACCTACCGA
GGAGCTTTCCAGAATCTGTTCCAGAGCGTGCGCGAAGTGATCCAGAACCCGGGCCCCAGG
CACCCAGAGGCCGCGAGCGCAGCACCTCCCGGCGCCAGTTTGCTGCTGCTGCAGCAGCAG
CAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAAGAGACT
AGCCCCAGGCAGCAGCAGCAGCAGCAGGGTGAGGATGGTTCTCCCCAAGCCCATCGTAGA
GGCCCCACAGGCTACCTGGTCCTGGATGAGGAACAGCAACCTTCACAGCCGCAGTCGGCC
CTGGAGTGCCACCCCGAGAGAGGTTGCGTCCCAGAGCCTGGAGCCGCCGTGGCCGCCAGC
AAGGGGCTGCCGCAGCAGCTGCCAGCACCTCCGGACGAGGATGACTCAGCTGCCCCATCC
ACGTTGTCCCTGCTGGGCCCCACTTTCCCCGGCTTAAGCAGCTGCTCCGCTGACCTTAAA
GACATCCTGAGCGAGGCCAGCACCATGCAACTCCTTCAGCAACAGCAGCAGGAAGCAGTA
TCCGAAGGCAGCAGCAGCGGGAGAGCGAGGGAGGCCTCGGGGGCTCCCACTTCCTCCAAG
GACAATTACTTAGGGGGCACTTCGACCATTTCTGACAACGCCAAGGAGTTGTGTAAGGCA
GTGTCGGTGTCCATGGGCCTGGGTGTGGAGGCGTTGGAGCATCTGAGTCCAGGGGAACAG
CTTCGGGGGGATTGCATGTACGCCCCACTTTTGGGAGTTCCACCCGCTGTGCGTCCCACT
CCTTGTGCCCCATTGGCCGAATGCAAAGGTTCTCTGCTAGACGACAGCGCAGGCAAGAGC
ACTGAAGATACTGCTGAGTATTCCCCTTTCAAGGGAGGTTACACCAAAGGGCTAGAAGGC
GAGAGCCTAGGCTGCTCTGGCAGCGCTGCAGCAGGGAGCTCCGGGACACTTGAACTGCCG
TCTACCCTGTCTCTCTACAAGTCCGGAGCACTGGACGAGGCAGCTGCGTACCAGAGTCGC
GACTACTACAACTTTCCACTGGCTCTGGCCGGACCGCCGCCCCCTCCGCCGCCTCCCCAT
CCCCACGCTCGCATCAAGCTGGAGAACCCGCTGGACTACGGCAGCGCCTGGGCGGCTGCG
GCGGCGCAGTGCCGCTATGGGGACCTGGCGAGCCTGCATGGCGCGGGTGCAGCGGGACCC
GGTTCTGGGTCACCCTCAGCCGCCGCTTCCTCATCCTGGCACACTCTCTTCACAGCCGAA
GAAGGCCAGTTGTATGGACCGTGTGGTGGTGGTGGGGGTGGTGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGAGGCGGGAGCTGTAGCCCCCTAC
GGCTACACTCGGCCCCCTCAGGGGCTGGCGGGCCAGGAAAGCGACTTCACCGCACCTGAT
GTGTGGTACCCTGGCGGCATGGTGAGCAGAGTGCCCTATCCCAGTCCCACTTGTGTCAAA
AGCGAAATGGGCCCCTGGATGGATAGCTACTCCGGACCTTACGGGGACATGCGTTTGGAG
ACTGCCAGGGACCATGTTTTGCCCATTGACTATTACTTTCCACCCCAGAAGACCTGCCTG
ATCTGTGGAGATGAAGCTTCTGGGTGTCACTATGGAGCTCTCACATGTGGAAGCTGCAAG
GTCTTCTTCAAAAGAGCCGCTGAAGGGAAACAGAAGTACCTGTGCGCCAGCAGAAATGAT
TGCACTATTGATAAATTCCGAAGGAAAAATTGTCCATCTTGTCGTCTTCGGAAATGTTAT
GAAGCAGGGATGACTCTGGGAGCCCGGAAGCTGAAGAAACTTGGTAATCTGAAACTACAG
GAGGAAGGAGAGGCTTCCAGCACCACCAGCCCCACTGAGGAGACAACCCAGAAGCTGACA
GTGTCACACATTGAAGGCTATGAATGTCAGCCCATCTTTCTGAATGTCCTGGAAGCCATT
GAGCCAGGTGTAGTGTGTGCTGGACACGACAACAACCAGCCCGACTCCTTTGCAGCCTTG
CTCTCTAGCCTCAATGAACTGGGAGAGAGACAGCTTGTACACGTGGTCAAGTGGGCCAAG
GCCTTGCCTGGCTTCCGCAACTTACACGTGGACGACCAGATGGCTGTCATTCAGTACTCC
TGGATGGGGCTCATGGTGTTTGCCATGGGCTGGCGATCCTTCACCAATGTCAACTCCAGG
ATGCTCTACTTCGCCCCTGATCTGGTTTTCAATGAGTACCGCATGCACAAGTCCCGGATG
TACAGCCAGTGTGTCCGAATGAGGCACCTCTCTCAAGAGTTTGGATGGCTCCAAATCACC
CCCCAGGAATTCCTGTGCATGAAAGCACTGCTACTCTTCAGCATTATTCCAGTGGATGGG
CTGAAAAATCAAAAATTCTTTGATGAACTTCGAATGAACTACATCAAGGAACTCGATCGT
ATCATTGCATGCAAAAGAAAAAATCCCACATCCTGCTCAAGACGCTTCTACCAGCTCACC
AAGCTCCTGGACTCCGTGCAGCCTATTGCGAGAGAGCTGCATCAGTTCACTTTTGACCTG
CTAATCAAGTCACACATGGTGAGCGTGGACTTTCCGGAAATGATGGCAGAGATCATCTCT
GTGCAAGTGCCCAAGATCCTTTCTGGGAAAGTCAAGCCCATCTATTTCCACACCCAGTGA


# Macromolecular_Interacting_Partner_6_GenBank_ID_Gene:
M20132

# Macromolecular_Interacting_Partner_6_Chromosome_Location:
Chromosome:X

# Macromolecular_Interacting_Partner_6_Locus:
Xq11.2-q12

# Macromolecular_Interacting_Partner_6_SNPs:
rs9332970; rs9332971; rs9332968; rs6154; rs6153; rs6152; rs2767564; rs1926927; rs7065472; rs1337077; rs1337078; rs7064188; rs1337080; rs2255702; rs1204038; rs5918757; rs4827547; rs12007252; rs5918760; rs1204039; rs1337079; rs1926926; rs4827545; rs1572500; rs5919394; rs2361634; rs1572501; rs2207040; rs7061037; rs4827546; rs12014709; rs5919393; rs12011519; rs6624304; rs16989056; rs1361038; rs5919402; rs2361630; rs12009820; rs5918763; rs5031002; rs1337076; rs5965433; rs5918762; rs17217069; rs2361629; rs1204040; rs12010355; rs12009650; rs4827400; rs5919408; rs12862891; rs4618851; rs2885324; rs1926925; rs12009160; rs4261023; rs5918764; rs7053042; rs5919395; rs7053539; rs12007014; rs5919411; rs9282610; rs12011793; rs34899607; rs5919409; rs6625192; rs1337075; rs4993619; rs16989058; rs5919396; rs5919403; rs12396249; rs12011839; rs11795851; rs34135606; rs11797145; rs16990313; rs12011518; rs5918758; rs34070681; rs12014623; rs4393047; rs11798429; rs5919392; rs7474293; rs16990322; rs12007513; rs11497352; rs34769252; rs9332969; rs1800053; rs9332972; rs12394583; rs12558349; rs34279752; rs34542167; rs12850901; rs12835888; rs12353686; rs12855990; rs11300116; rs34908546; rs3070073; rs4281240; rs28753893; rs12856708; rs4451455; rs7061565; rs35645431; rs1577774; rs36064324; rs1361039; rs35122308; rs35099711; rs35535776; rs11461009; rs1577776; rs12833196; rs35625503; rs12846224; rs12836266; rs36110198; rs10706297; rs12834564; rs12836056; rs12849709; rs12848807; rs4827399; rs6624302; rs4500207; rs7054901; rs34043358; rs2885320; rs5016202; rs4540555; rs12833578; rs12013056; rs35809402; rs7060002; rs5918761; rs5919412; rs1577773; rs35044641; rs34070729; rs10856045; rs34434496; rs5919400; rs4489446; rs28402724; rs34642310; rs35624751; rs2361632; rs34878648; rs5965428; rs1204041; rs11380458; rs12864107; rs12837932; rs5965427; rs34951605; rs12393203; rs35953490; rs12835668; rs7055888; rs4459010; rs2878448; rs11094028; rs28580341; rs5919404; rs12832474; rs35888906; rs12864066; rs12847395; rs12395102; rs5919399; rs10622053; rs10553807; rs3070104; rs36168959; rs12840191; rs12837043; rs12848810; rs36099326; rs12009829; rs34077836; rs9699316; rs34754285; rs12851299; rs35747505; rs10564872; rs12835243; rs7052941; rs35098115; rs12859822; rs2878449; rs3795188; rs7062560; rs34742794; rs12851535; rs35630657; rs5964604; rs12849096; rs35546171; rs4497110; rs5965426; rs12401043; rs4827402; rs11799017; rs12843690; rs35819077; rs34792775; rs35617974; rs12838075; rs34664808; rs4292843; rs1577778; rs34997701; rs5918756; rs12857875; rs11428245; rs2361636; rs11424271; rs6653153; rs11367126; rs5919410; rs12843659; rs12835932; rs6625193; rs12851734; rs35316597; rs12851221; rs5016201; rs4413923; rs1577775; rs12836926; rs12856976; rs5919398; rs12851526; rs34418137; rs34604425; rs12689165; rs35377720; rs12863183; rs2361635; rs12857354; rs7065530; rs12835940; rs35020767; rs35774629; rs35847971; rs4827549; rs1577777; rs12857337; rs2223823; rs3795189; rs5919397; rs12837784; rs12836735; rs36063595; rs35442632; rs12833469; rs36075392; rs34317430; rs4446868; rs6625199; rs11316774; rs12862050; rs11094026; rs5965425; rs34851516; rs7474075; rs5965429; rs11351755; rs2070757; rs34566600; rs35506153; rs35025615; rs3032358; rs10060; rs17302090; rs1931537; rs2282289; rs2362520; rs5919413; rs5919414; rs7440

# Macromolecular_Interacting_Partner_6_General_References:
3216866; 2594783; 2342476; 3174628; 12361945; 2911578; 2293020; 2917688; 3353726; 3377788; 2546571; 3353727; 1775137; 1561105; 9096391; 10332029; 10400640; 10625666; 10930412; 12415108; 12612053; 10840043; 11906285; 1458719; 8339746; 8240973; 7937057; 7626493; 9016528; 2260966; 2082179; 1856263; 1999491; 2010552; 2062380; 1609793; 1424203; 1426313; 1487249; 1307250; 1569163; 1464650; 1430233; 1562539; 1316540; 1480178; 1303262; 1631125; 8213813; 8224266; 8103398; 8281139; 8281140; 8325932; 8325950; 8097257; 8096390; 8274409; 8446106; 8413310; 8145761; 7511268; 8292051; 8187068; 7910529; 7909256; 8205256; 8033918; 8162033; 7981687; 7981689; 8126121; 7962294; 8040309; 7929841; 7993455; 7970939; 8830623; 7712463; 7641413; 7671849; 7633398; 7537149; 7581399; 7591265; 7673412; 8530589; 7649358; 7723794; 8723113; 9816170; 9039340; 9001799; 8824883; 8550758; 8626869; 8768864; 8823308; 8918984; 8683794; 8647313; 8809734; 8628719; 8827083; 9106550; 9000575; 9196614; 9160185; 9007482; 8990010; 9438000; 9184448; 9255042; 9329414; 9252933; 9328206; 9302173; 9544375; 9698822; 9788719; 9610419; 9856504; 9554754; 9554755; 9543136; 9768671; 9851768; 9627582; 9607727; 10470409; 10363963; 10502786; 10571951; 10221692; 10404311; 10022458; 10629558; 10569618; 10543676; 10221770; 10598582; 10590024; 10458483; 10092153; 10706109; 10690872; 11587068; 11744994

# Macromolecular_Interacting_Partner_6_References:
10701889; 12007895; 16759873

# Macromolecular_Interacting_Partner_7_ID:
7623

# Macromolecular_Interacting_Partner_7_Name:
Insulin-like growth factor-binding protein 3 precursor

# Macromolecular_Interacting_Partner_7_Synonyms:
IGFBP-3; IBP- 3; IGF-binding protein 3

# Macromolecular_Interacting_Partner_7_Gene_Name:
IGFBP3

# Macromolecular_Interacting_Partner_7_Protein_Sequence:
>Insulinlike growth factorbinding protein 3 precursor
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK

# Macromolecular_Interacting_Partner_7_Number_of_Residues:
291

# Macromolecular_Interacting_Partner_7_Molecular_Weight:
31674

# Macromolecular_Interacting_Partner_7_Theoretical_pI:
8.78

# Macromolecular_Interacting_Partner_7_GO_Classification:
>>>
Function:  binding
Function:  protein binding
Function:  growth factor binding
Function:  insulin-like growth factor binding
 ||
>>>
Process:  regulation of biological process
Process:  regulation of growth
Process:  regulation of cell growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_7_General_Function:
Not Available

# Macromolecular_Interacting_Partner_7_Specific_Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

# Macromolecular_Interacting_Partner_7_Pathway:
Not Available

# Macromolecular_Interacting_Partner_7_Reaction:
Not Available

# Macromolecular_Interacting_Partner_7_Pfam_Domain_Function:
PF00219:IGFBP;
PF00086:Thyroglobulin_1

# Macromolecular_Interacting_Partner_7_Signals:
1-27

# Macromolecular_Interacting_Partner_7_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_7_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_7_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_7_GenBank_ID_Protein:
183116

# Macromolecular_Interacting_Partner_7_SwissProt_ID:
IBP3_HUMAN (P17936)

# Macromolecular_Interacting_Partner_7_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_7_Genecard_id:
IGFBP3

# Macromolecular_Interacting_Partner_7_Geneatlas_id:
IGFBP3

# Macromolecular_Interacting_Partner_7_hgnc_id:
HGNC:5472

# Macromolecular_Interacting_Partner_7_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_7_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_7_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_7_Gene_Sequence:
>876 bp
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGGGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG

# Macromolecular_Interacting_Partner_7_GenBank_ID_Gene:
M31159

# Macromolecular_Interacting_Partner_7_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_7_Locus:
7p13-p12

# Macromolecular_Interacting_Partner_7_SNPs:
rs9282734; rs2854746; rs6950868; rs6670; rs2453840; rs2453839; rs34505796; rs35496550; rs35751739; rs34460927; rs34835646; rs3110697; rs6413441; rs6950802; rs2854747; rs6953668; rs33979592; rs2471551; rs12540724; rs3793345; rs2453837; rs35890775; rs34508316; rs34678704; rs10255707; rs34091405; rs17847673; rs1800906; rs35052563; rs34876509; rs34463602; rs2854750; rs35440925; rs34672517; rs9282735; rs10282088; rs11765572; rs10252403; rs2132570; rs13223993; rs10238613; rs2132572; rs2132571; rs13241830; rs35709394; rs35258778; rs34087654; rs34122177; rs34480712; rs34077804; rs3763500; rs2854744; rs35712717; rs17847676; rs34257987; rs34239916; rs34663167; rs35925180; rs2471549; rs34735423; rs11537920; rs11537915; rs9911; rs11537916; rs11537919; rs1050566; rs34735308; rs11537917; rs35704214; rs34930524; rs35689043; rs2515697; rs2854749; rs34515169; rs34833729; rs17847674; rs2645039; rs34988007; rs3110696; rs35683959; rs5883949; rs34331516; rs34014638; rs2645038; rs34898986; rs35350851; rs2645037; rs13230567; rs35872082; rs34720178; rs2854751; rs34424795; rs2854748; rs35855621; rs35610649; rs11292609; rs34881353; rs34006338; rs4302754; rs34533777; rs34351332; rs35017224; rs2854745; rs34097876; rs34058026; rs34939676; rs35533791; rs35919935; rs2645036; rs35300175; rs11773396; rs10230447; rs12671457; rs12671484; rs12702181; rs2088300; rs2088301; rs2270628; rs2453836; rs2515696; rs885555; rs903889; rs924140

# Macromolecular_Interacting_Partner_7_General_References:
2464130; 1695633; 7508771; 12853948; 1697583; 14561895

# Macromolecular_Interacting_Partner_7_References:
14763914; 15021445; 15590985; 15941949

# Macromolecular_Interacting_Partner_8_ID:
7844

# Macromolecular_Interacting_Partner_8_Name:
Insulin-like growth factor IA precursor

# Macromolecular_Interacting_Partner_8_Synonyms:
IGF-IA; Somatomedin C; Mechano growth factor; MGF

# Macromolecular_Interacting_Partner_8_Gene_Name:
IGF1

# Macromolecular_Interacting_Partner_8_Protein_Sequence:
>Insulinlike growth factor IA precursor
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKEVHLKNASRGSAGNKNYRM

# Macromolecular_Interacting_Partner_8_Number_of_Residues:
153

# Macromolecular_Interacting_Partner_8_Molecular_Weight:
17026

# Macromolecular_Interacting_Partner_8_Theoretical_pI:
9.40

# Macromolecular_Interacting_Partner_8_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
Function:  neuropeptide hormone activity
Function:  prothoracicotrophic hormone activity
 ||
>>>
Process:  physiological process
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_8_General_Function:
Not Available

# Macromolecular_Interacting_Partner_8_Specific_Function:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity

# Macromolecular_Interacting_Partner_8_Pathway:
Not Available

# Macromolecular_Interacting_Partner_8_Reaction:
Not Available

# Macromolecular_Interacting_Partner_8_Pfam_Domain_Function:
PF00049:Insulin

# Macromolecular_Interacting_Partner_8_Signals:
1-21

# Macromolecular_Interacting_Partner_8_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_8_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_8_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_8_GenBank_ID_Protein:
183110

# Macromolecular_Interacting_Partner_8_SwissProt_ID:
IGF1A_HUMAN (P01343)

# Macromolecular_Interacting_Partner_8_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_8_Genecard_id:
IGF1

# Macromolecular_Interacting_Partner_8_Geneatlas_id:
IGF1

# Macromolecular_Interacting_Partner_8_hgnc_id:
HGNC:5464

# Macromolecular_Interacting_Partner_8_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_8_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_8_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_8_Gene_Sequence:
>462 bp
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG

# Macromolecular_Interacting_Partner_8_GenBank_ID_Gene:
M14156

# Macromolecular_Interacting_Partner_8_Chromosome_Location:
Chromosome:12

# Macromolecular_Interacting_Partner_8_Locus:
12q22-q23

# Macromolecular_Interacting_Partner_8_SNPs:
rs17884626; rs3729846; rs6220; rs6219; rs5742714; rs6214; rs6216; rs5742707; rs6217; rs6222; rs3730192; rs3730205; rs5742711; rs3730204; rs5742705; rs6221; rs5742713; rs5742715; rs3730189; rs5742706; rs1063599; rs6218; rs5742700; rs6215; rs35528193; rs17881987; rs3209674; rs6212; rs3730201; rs3730190; rs5742704; rs1140655; rs17879349; rs5031032; rs978458; rs2373721; rs1019731; rs2195240; rs2288378; rs2195239; rs5742629; rs11111274; rs5742657; rs2033178; rs7314527; rs10860869; rs4764696; rs10778176; rs9989002; rs4764883; rs12310428; rs5009837; rs5742659; rs9308315; rs972936; rs5742683; rs4764886; rs10735380; rs4764887; rs7136446; rs5742632; rs7956547; rs5742692; rs17727519; rs6213; rs17880975; rs17882264; rs10047577; rs2072592; rs17879892; rs5742627; rs5742634; rs6539035; rs10860865; rs5742694; rs17032565; rs5742620; rs5742644; rs12821878; rs11831436; rs7957559; rs5742696; rs10745942; rs17032634; rs5742682; rs1520221; rs17727841; rs11829586; rs1549593; rs2195242; rs10860867; rs9651925; rs17884734; rs17884998; rs5742658; rs4764698; rs11111265; rs5742665; rs11831702; rs12305089; rs12423791; rs5742614; rs5742639; rs5742643; rs5742690; rs17885092; rs12299353; rs2162679; rs5742695; rs5742653; rs5742623; rs17032623; rs5742615; rs11837195; rs11111272; rs5742668; rs5742626; rs5742624; rs5742678; rs5742637; rs11111267; rs1520220; rs7132915; rs5742667; rs5742652; rs5742669; rs5742618; rs10778174; rs4764697; rs28682289; rs5742671; rs11111266; rs4764699; rs5742655; rs5742638; rs10778175; rs5742666; rs5742617; rs5742663; rs12833855; rs5742689; rs5742622; rs17885209; rs7300373; rs5742654; rs5742645; rs7971494; rs5742636; rs10745940; rs17796225; rs5742661; rs35996361; rs17886202; rs5742656; rs5742686; rs5742670; rs2373722; rs35524121; rs17882461; rs11111269; rs35626892; rs11111262; rs5742647; rs10860864; rs17882373; rs5742664; rs12313279; rs17884900; rs5742625; rs17878658; rs7296464; rs17879380; rs12426645; rs5742635; rs5742688; rs5742628; rs6539036; rs5742672; rs34300540; rs5742649; rs4764885; rs35897406; rs35349902; rs35209973; rs5742630; rs17882108; rs17878845; rs17885477; rs1520222; rs17886416; rs17881922; rs35437018; rs17879867; rs12316064; rs5742633; rs34291100; rs34311929; rs5742660; rs5742641; rs17878318; rs5742648; rs17884646; rs11608757; rs5742621; rs5742684; rs12425939; rs4764884; rs10860866; rs17032577; rs17878342; rs35767; rs5742722; rs5742723; rs2946834; rs11829707; rs5742720; rs5742612; rs11829693; rs2288377; rs5742716; rs3730195; rs3730193; rs35365615; rs5742702; rs3730211; rs3730224; rs5742712; rs3730210; rs4479044; rs3730207; rs5800508; rs34632512; rs17884961; rs5742698; rs3730206; rs3730203; rs35306040; rs35234844; rs3730188; rs3730226; rs17885397; rs5742703; rs5742701; rs2114911; rs3730218; rs5742708; rs3730221; rs28399924; rs35770817; rs1142050; rs3730200; rs35042457; rs1063600; rs14970; rs34621369; rs5742709; rs3032446; rs3730209; rs3730191; rs5742613; rs3730223; rs17847185; rs5742710; rs3730212; rs3730208; rs17847188; rs35359199; rs5800507; rs17886337; rs35249557; rs12817059; rs9282710; rs34903472; rs5742693; rs12299690; rs34647656; rs5742675; rs12810139; rs10745941; rs2373723; rs17879585; rs17880891; rs12320356; rs35140968; rs5800510; rs17879693; rs17882696; rs35437431; rs35174508; rs5742687; rs17885230; rs11608743; rs12368271; rs17882221; rs2373724; rs17886520; rs35775928; rs5742619; rs10860863; rs17885564; rs5742676; rs5742677; rs11421600; rs34805296; rs12816379; rs11608742; rs11111273; rs17879010; rs17886798; rs17882149; rs34599859; rs12817072; rs3032454; rs34813772; rs10860868; rs17879390; rs11111268; rs17885210; rs9282711; rs17886237; rs35222135; rs17878871; rs3729847; rs10557735; rs12320358; rs12819048; rs17878637; rs34545292; rs17882016; rs17878716; rs10614489; rs34568432; rs5742650; rs11111279; rs17881804; rs17878620; rs5742616; rs35813377; rs35403470; rs5742640; rs5742673; rs35865277; rs17879664; rs10685119; rs5742680; rs11111263; rs12314338; rs17878397; rs11111271; rs17880004; rs5742681; rs5742646; rs35004383; rs11111278; rs34817710; rs36103805; rs11111270; rs5742651; rs17881582; rs17885105; rs12816545; rs17882697; rs5742674; rs35123842; rs10161018; rs17882126; rs35993329; rs5742697; rs764911; rs11111277; rs35635523; rs12809983; rs5742631; rs1015693; rs17878818; rs12370356; rs11111276; rs35660465; rs7297946; rs11111281; rs11305762; rs34097393; rs34199594; rs5742662; rs17881697; rs36047405; rs36123817; rs4764882; rs17878303; rs36005419; rs17886265; rs17728444; rs12319588; rs17884880; rs34918171; rs11111264; rs35433913; rs5800512; rs17885262; rs17879785; rs17879563; rs17883650; rs34618338; rs34085295; rs34241965; rs17883689; rs34212937; rs17882244; rs17887104; rs34938746; rs35261849; rs12816586; rs17885578; rs17882564; rs17884984; rs17879080; rs17879837; rs12820619; rs11111280; rs12229818; rs17885158; rs5742691; rs34800889; rs12821533; rs11837097; rs5742679; rs17882237; rs12301183; rs34432139; rs17886964; rs34588740; rs5742685; rs10542027; rs35407198; rs5742642; rs17882333; rs10592539; rs5800511; rs17885342; rs35384466; rs3033405; rs12830260; rs2217241; rs3033407; rs17879774; rs35806302; rs17882374; rs5742717; rs10665874; rs5742719; rs5800513; rs7487728; rs5742718; rs17884864; rs5742721; rs10860860; rs10860861; rs10860862; rs11111259; rs11111260; rs11111261; rs11111282; rs11831864; rs12301163; rs12301559; rs12579077; rs12579108; rs1457601; rs17032483; rs17032487; rs17032648; rs2373720; rs2946831; rs2971575; rs2971577; rs35765; rs35766; rs7316439; rs7980083; rs855201; rs9919733

# Macromolecular_Interacting_Partner_8_General_References:
2937782; 6358902; 2935423; 3002851; 2018498; 1372070; 6382022; 632300; 6189745; 2036417; 1319992; 3242681; 8857020

# Macromolecular_Interacting_Partner_8_References:
14667889; 15021445; 16381008

# Macromolecular_Interacting_Partner_9_ID:
7973

# Macromolecular_Interacting_Partner_9_Name:
Inhibin beta A chain precursor

# Macromolecular_Interacting_Partner_9_Synonyms:
Activin beta-A chain; Erythroid differentiation protein; EDF

# Macromolecular_Interacting_Partner_9_Gene_Name:
INHBA

# Macromolecular_Interacting_Partner_9_Protein_Sequence:
>Inhibin beta A chain precursor
MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK
HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT
SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK
HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV
RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS
EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG
TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV
EECGCS

# Macromolecular_Interacting_Partner_9_Number_of_Residues:
426

# Macromolecular_Interacting_Partner_9_Molecular_Weight:
47443

# Macromolecular_Interacting_Partner_9_Theoretical_pI:
8.10

# Macromolecular_Interacting_Partner_9_GO_Classification:
>>>
Function:  growth factor activity
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  growth
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_9_General_Function:
Not Available

# Macromolecular_Interacting_Partner_9_Specific_Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins

# Macromolecular_Interacting_Partner_9_Pathway:
Not Available

# Macromolecular_Interacting_Partner_9_Reaction:
Not Available

# Macromolecular_Interacting_Partner_9_Pfam_Domain_Function:
PF00019:TGF_beta;
PF00688:TGFb_propeptide

# Macromolecular_Interacting_Partner_9_Signals:
1-20

# Macromolecular_Interacting_Partner_9_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_9_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_9_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_9_GenBank_ID_Protein:
307069

# Macromolecular_Interacting_Partner_9_SwissProt_ID:
INHBA_HUMAN (P08476)

# Macromolecular_Interacting_Partner_9_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_9_Genecard_id:
INHBA

# Macromolecular_Interacting_Partner_9_Geneatlas_id:
INHBA

# Macromolecular_Interacting_Partner_9_hgnc_id:
HGNC:6066

# Macromolecular_Interacting_Partner_9_PDB_ID:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_9_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_9_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_9_Gene_Sequence:
>1281 bp
ATGCCCTTGCTTTGGCTGAGAGGATTTCTGTTGGCAAGTTGCTGGATTATAGTGAGGAGT
TCCCCCACCCCAGGATCCGAGGGGCACAGCGCGGCCCCCGACTGTCCGTCCTGTGCGCTG
GCCGCCCTCCCAAAGGATGTACCCAACTCTCAGCCAGAGATGGTGGAGGCCGTCAAGAAG
CACATTTTAAACATGCTGCACTTGAAGAAGAGACCCGATGTCACCCAGCCGGTACCCAAG
GCGGCGCTTCTGAACGCGATCAGAAAGCTTCATGTGGGCAAAGTCGGGGAGAACGGGTAT
GTGGAGATAGAGGATGACATTGGAAGGAGGGCAGAAATGAATGAACTTATGGAGCAGACC
TCGGAGATCATCACGTTTGCCGAGTCAGGAACAGCCAGGAAGACGCTGCACTTCGAGATT
TCCAAGGAAGGCAGTGACCTGTCAGTGGTGGAGCGTGCAGAAGTCTGGCTCTTCCTAAAA
GTCCCCAAGGCCAACAGGACCAGGACCAAAGTCACCATCCGCCTCTTCCAGCAGCAGAAG
CACCCGCAGGGCAGCTTGGACACAGGGGAAGAGGCCGAGGAAGTGGGCTTAAAGGGGGAG
AGGAGTGAACTGTTGCTCTCTGAAAAAGTAGTAGACGCTCGGAAGAGCACCTGGCATGTC
TTCCCTGTCTCCAGCAGCATCCAGCGGTTGCTGGACCAGGGCAAGAGCTCCCTGGACGTT
CGGATTGCCTGTGAGCAGTGCCAGGAGAGTGGCGCCAGCTTGGTTCTCCTGGGCAAGAAG
AAGAAGAAAGAAGAGGAGGGGGAAGGGAAAAAGAAGGGCGGAGGTGAAGGTGGGGCAGGA
GCAGATGAGGAAAAGGAGCAGTCGCACAGACCTTTCCTCATGCTGCAGGCCCGGCAGTCT
GAAGACCACCCTCATCGCCGGCGTCGGCGGGGCTTGGAGTGTGATGGCAAGGTCAACATC
TGCTGTAAGAAACAGTTCTTTGTCAGTTTCAAGGACATCGGCTGGAATGACTGGATCATT
GCTCCCTCTGGCTATCATGCCAACTACTGCGAGGGTGAGTGCCCGAGCCATATAGCAGGC
ACGTCCGGGTCCTCACTGTCCTTCCACTCAACAGTCATCAACCACTACCGCATGCGGGGC
CATAGCCCCTTTGCCAACCTCAAATCGTGCTGTGTGCCCACCAAGCTGAGACCCATGTCC
ATGTTGTACTATGATGATGGTCAAAACATCATCAAAAAGGACATTCAGAACATGATCGTG
GAGGAGTGTGGGTGCTCATAG

# Macromolecular_Interacting_Partner_9_GenBank_ID_Gene:
M13436

# Macromolecular_Interacting_Partner_9_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_9_Locus:
7p15-p13

# Macromolecular_Interacting_Partner_9_SNPs:
rs41294833; rs2237436; rs2237435; rs2237432; rs3801158; rs11770488; rs2282921; rs6958234; rs2237434; rs2877098; rs35168740; rs35118590; rs35239129; rs10263517; rs13230382; rs35784619; rs35446171; rs3030163; rs34094470; rs2330258; rs33937463; rs34410146; rs35954856; rs35515062; rs11388094; rs2237433; rs3030167; rs35205139; rs36006177; rs34883301; rs28536672; rs6961410; rs34617847; rs35332768; rs1003291; rs10261223; rs1046634; rs10486719; rs1122291; rs11522987; rs11772989; rs12333333; rs12333401; rs12532252; rs12701929; rs12701930; rs17705333; rs2007475; rs3735360; rs6977571; rs998190

# Macromolecular_Interacting_Partner_9_General_References:
3754442; 3267209; 1777673; 12853948; 3758355; 12660162

# Macromolecular_Interacting_Partner_9_References:
10775170; 11232020; 14668202

# Macromolecular_Interacting_Partner_10_ID:
8081

# Macromolecular_Interacting_Partner_10_Name:
Leptin precursor

# Macromolecular_Interacting_Partner_10_Synonyms:
Obesity factor; Obese protein

# Macromolecular_Interacting_Partner_10_Gene_Name:
LEP

# Macromolecular_Interacting_Partner_10_Protein_Sequence:
>Leptin precursor
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

# Macromolecular_Interacting_Partner_10_Number_of_Residues:
167

# Macromolecular_Interacting_Partner_10_Molecular_Weight:
18641

# Macromolecular_Interacting_Partner_10_Theoretical_pI:
6.34

# Macromolecular_Interacting_Partner_10_GO_Classification:
>>>
Function:  signal transducer activity
Function:  receptor binding
Function:  hormone activity
 ||
>>>
Process:  cellular process
Process:  cell communication
Process:  signal transduction
 ||
>>>
Component:  extracellular region

# Macromolecular_Interacting_Partner_10_General_Function:
Not Available

# Macromolecular_Interacting_Partner_10_Specific_Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass

# Macromolecular_Interacting_Partner_10_Pathway:
Not Available

# Macromolecular_Interacting_Partner_10_Reaction:
Not Available

# Macromolecular_Interacting_Partner_10_Pfam_Domain_Function:
PF02024:Leptin

# Macromolecular_Interacting_Partner_10_Signals:
1-21

# Macromolecular_Interacting_Partner_10_Transmembrane_Regions:
Not Available

# Macromolecular_Interacting_Partner_10_Metabolic_Importance:
Not Available

# Macromolecular_Interacting_Partner_10_EC_Link:
Not Available

# Macromolecular_Interacting_Partner_10_GenBank_ID_Protein:
623332

# Macromolecular_Interacting_Partner_10_SwissProt_ID:
LEP_HUMAN (P41159)

# Macromolecular_Interacting_Partner_10_swissprot_Name:
Not Available

# Macromolecular_Interacting_Partner_10_Genecard_id:
LEP

# Macromolecular_Interacting_Partner_10_Geneatlas_id:
LEP

# Macromolecular_Interacting_Partner_10_hgnc_id:
HGNC:6553

# Macromolecular_Interacting_Partner_10_PDB_ID:
1AX8

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Image:
Not Available

# Macromolecular_Interacting_Partner_10_ThreeD_Structure_Text:
Not Available

# Macromolecular_Interacting_Partner_10_Subcellular_Location:
Secreted protein

# Macromolecular_Interacting_Partner_10_Gene_Sequence:
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA

# Macromolecular_Interacting_Partner_10_GenBank_ID_Gene:
U18915

# Macromolecular_Interacting_Partner_10_Chromosome_Location:
Chromosome:7

# Macromolecular_Interacting_Partner_10_Locus:
7q31.3

# Macromolecular_Interacting_Partner_10_SNPs:
rs17151919; rs13306517; rs28954113; rs11763517; rs4731426; rs10954173; rs11761556; rs4731427; rs2167270; rs7791621; rs10257175; rs12706832; rs11760956; rs7795794; rs28954116; rs11978419; rs10244329; rs17151922; rs2278814; rs28959471; rs10954174; rs4236625; rs7796202; rs28954117; rs28959470; rs28954095; rs28954101; rs28954086; rs28954099; rs28959468; rs3750034; rs28954093; rs2278815; rs2122627; rs28954379; rs28959474; rs28954082; rs41457646; rs28954114; rs28954096; rs28959476; rs28954084; rs28954102; rs28954100; rs2060713; rs28954090; rs28954098; rs28954105; rs28954118; rs11980266; rs28954091; rs12706831; rs28959475; rs28954094; rs28954083; rs28756049; rs11973652; rs3793162; rs17151913; rs17151914; rs6956510; rs2071045; rs3828942; rs7788818; rs10264361; rs28954109; rs28954110; rs28954108; rs28954111; rs791616; rs28954376; rs28954081; rs6976701; rs10262600; rs28954369; rs28954080; rs28954371; rs34104384; rs4728096; rs791620; rs28954372; rs28954373; rs28954375; rs35048003; rs28959478; rs10258300; rs12536535; rs28954378; rs13228377; rs1800564; rs1800583; rs28954097; rs11380467; rs35394014; rs28959469; rs10676401; rs28954106; rs1031340; rs28954115; rs1349398; rs34219283; rs28959472; rs28954088; rs10243710; rs6966536; rs28954104; rs10620014; rs34457895; rs13306516; rs33910507; rs28954107; rs41526944; rs41434248; rs28954087; rs34728887; rs28954103; rs28959473; rs41528456; rs17617757; rs28954089; rs28954092; rs34052732; rs10277407; rs28954112; rs41474844; rs13306518; rs35447711; rs34046133; rs36212573; rs28959477; rs36219262; rs791618; rs28954370; rs791619; rs34669250; rs10598051; rs28954377; rs36219261; rs28391558; rs791617; rs28954374; rs36219260; rs10249476; rs10264838; rs10276311; rs10487506; rs10954175; rs10954176; rs11770725; rs12535708; rs12535747; rs12537573; rs13245201; rs1349419; rs1376268; rs16871960; rs17151895; rs2060715; rs2167271; rs35854831; rs4731423; rs4731424; rs4731428; rs4731429; rs4731430; rs6949498; rs712722; rs7778154; rs7782257; rs7798338; rs7799039; rs7801674; rs7802530; rs791604; rs791606; rs791607; rs791608; rs791610; rs791611; rs791612; rs791613; rs791614; rs791615

# Macromolecular_Interacting_Partner_10_General_References:
7984236; 7789654; 8626726; 7499240; 8621021; 10428856; 9166907; 9144295; 9500540

# Macromolecular_Interacting_Partner_10_References:
10076188; 10537117; 10965205; 11502810

End of HMDB00053

Beginning of HMDB00054
# Accession_No:
HMDB00054

# Creation_Date:
2005-11-16 15:48:42

# Update_Date:
2007-10-25 16:36:57

# biospider_lastupdate:
0000-00-00 00:00:00

# Common_Name:
Bilirubin

# Description:
A bile pigment that is a degradation product of HEME. -- Pubchem; Bilirubin is a yellow breakdown product of normal heme catabolism. Its levels are elevated in certain diseases and it is responsible for the yellow color of bruises. Bilirubin is an excretion product, and the body does not control levels. Bilirubin levels reflect the balance between production and excretion. Thus, there is no "normal" level of bilirubin. Bilirubin consists of an open chain of four pyrroles (tetrapyrrole); by contrast, the heme molecule is a ring of four pyrroles, called porphyrin. -- Wikipedia

# Synonyms:
(4Z,15Z)-Bilirubin IXa; (Z,Z)-Bilirubin IXa; 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionate; 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-Biline-8,12-dipropionic acid; 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8,12-dipropanoate; 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl)methyl)-4-methyl-5-[(Z)-(4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene; 3-(2-((3-(2-carboxyethyl)-4-methyl-5-((3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((4-methyl-5-oxo-3-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl)-1H-pyrrol-3-yl)propanoate; 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate;  3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoate; Bilirubin; Bilirubin IX-alpha; Cholerythrin; Hematoidin 

# Chemical_IUPAC_Name:
3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid

# Chemical_Formula:
C33H36N4O6

# Chemical_Structure:
tbl_chemical:::HMDB00054_ZOOM.png:::119283160047923892

# Chemical_Structure_thumb:
tbl_chemical:::HMDB00054_THUMB.png:::119283159823284225

# Taxonomy_Kingdom:
Organic

# Taxonomy_Class:
Tetrapyrroles; Porphyrins

# Taxonomy_Family:
Mammalian Metabolite

# Taxonomy_Species:
enamine; carboxylic acid; oxo(het)arene; alkene; aromatic compound; heterocyclic compound

# Taxonomy_Biofunction:
Component of Porphyrin and chlorophyll metabolism

# Taxonomy_Source:
Endogenous

# Molecular_Weight:
584.26349

# Molecular_Weight_Avg:
584.66217

# Smiles_String_isomeric:
CC1=C(C=C)C(NC1=O)=CC2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(N3)C=C4/NC(=O)C(C=C)=C4C)N2

# Smiles_String_canonical:
CC1=C(C=C)C(NC1=O)=CC2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(N3)C=C4NC(=O)C(C=C)=C4C)N2

# KEGG_Compound_ID:
C00486

# BioCyc_ID:
BILIRUBIN

# PubChem_CID:
5280352

# PubChem_SID:
8144728; 8616233; 10319019; 10474149; 11537670; 10687731; 155796

# OMIM_ID:
Not Available

# Metagene_ID:
GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY. FAVISM: 149; PYRUVATE KINASE DEFICIENCY: 138; INTOXICATION ACETAMINOPHEN [DD]: 389; GLYCOGENOSIS, TYPE VII. TARUI DISEASE: 167; TRIHYDROXYCOPROSTANIC ACIDEMIA. COPROSTANIC ACIDEMIA: 20; PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: 363; GALACTOSEMIA: 136; CRIGLER-NAJJAR SYNDROME TYPE II: 433; WILSON DISEASE: 178; CRIGLER-NAJJAR SYNDROME TYPE I: 432

# BiGG_ID:
35117

# Wikipedia_ID:
Bilirubin

# METLIN_ID:
81

# Ref_ID:
15858963; 2648917; 15245596; 15242029; 8903413; 15189696; 16100141; 12068294; 14761351; 15718382; 15173484; 16225094; 16163462; 15684703; 9262222; 16700327; 16440420; 15081641; 15249403; 15838745

# ChEBI_ID:
16990

# CAS_Registry_Number:
635-65-4

# InChI:
InChI=1/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

# Synthesis_Reference:
Not Available

# Melting_Point:
Not Available

# Melting_Point_predicted:
179.5 oC [Predicted by HMP]

# H2O_Solubility_Experimental:
0.009 mg/mL at 25 oC [BEILSTEIN]

# H2O_Solubility_Predicted:
9.64e-03 mg/mL [Predicted by ALOGPS]

# phys_charge:
-2

# State:
Solid

# LogP:
Not Available

# LogP_predicted:
3.23 [Predicted by ALOGPS]; 1.945 [Predicted by PubChem via XLOGP]; 5.04 [MEYLAN,WM & HOWARD,PH (1995)]

# MSDS_Material_Safety_Sheet:
tbl_chemical:::Bilirubin.pdf:::1132562194340562996

# MOL_File_Image:
JAVA MOL Viewer

# MOL_File_Text:
tbl_chemical:::Bilirubin.mol:::1132723803906308575

# SDF_File_[Text]:
tbl_chemical:::HMDB00054.sdf:::119283159298774470

# PDB_File_Calculated_Image:
JAVA PDB Viewer

# PDB_File_Calculated_Text:
tbl_chemical:::HMDB00054.pdb:::11928315965041301

# PDB_ID:
Not Available

# PDB_File_Experimental_Image:
JAVA PDB Viewer

# PDB_File_Experimental_Text:
Not Available

# H_NMR_Spectra_Wishart:
Not Available

# H_NMR_FIDS_Spectra_Wishart:
Not Available

# H_NMR_Instrument_Manufacturer_Wishart:
Varian

# Assignemnt_For_NMR_Spectra_Wishart:
Not Available

# H_NMR_Spectra_Sykes:
Not Available

# H_NMR_FIDS_Spectra_Sykes:
Not Available

# H_NMR_Instrument_Manufacturer_Sykes:
Varian

# Assignemnt_For_NMR_Spectra_Sykes:
Not Available

# C_NMR_Spectra:
Not Available

# C_NMR_FIDS_Spectra:
Not Available

# C_NMR_Instrument_Manufacturer:
Not Available

# Assignemnt_For_CNMR_Spectra:
Not Available

# 2D_HSQC_Spectra:
Not Available

# 2D_HSQC_FIDS_Spectra:
Not Available

# 2d_HSQC_Instrument_Manufacturer:
Not Available

# Assignemnt_For_NMR_Spectra_2DHSQC:
Not Available

# Predicted_H_NMR_Spectrum:
tbl_chemical:::Bilirubin.gif:::113273210326579170

# pred_hnmr_peaklist:
tbl_chemical:::HMDB00054_peaks.txt:::1156309514237430094

# Predicted_C_NMR_Spectrum:
tbl_chemical:::Bilirubin_C.gif:::1132737668914324871

# pred_cnmr_peaklist:
tbl_chemical:::HMDB00054_peaks.txt:::1156310704725388124

# Mass_Spectrum:
Not Available

# Simplied_Tocsy_Spectrum:
Not Available

# Simplied_Tocsy_Peaklist:
Not Available

# BMRB_Spectrum:
Not Available

# BMRB_Peaklist:
Not Available

# Cellular_Location:
Membrane (Predicted from LogP); Cytoplasm; endoplasmic reticulum; Extracellular

# Tissue_Location:
Bile Duct; Bone Marrow; Brain; Erythrocyte; Fibroblasts; Intestine; Kidney; Liver; Liver Predominantly; Lymph Node; Muscle; Myelin; Nerves; Neurons; Pancreas; Placenta; Platelet; Reticulocyte; Skin; Spleen; Thyroid Gland

# deuterated:
No

# Biofluid_Location:
Bile; Blood; CSF; Urine

# Concentration_[Normal]:
Urine	< 0.1	umol/mmol_creatinine	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests 4th Ed., 2006.
Blood	13.0 (5.0-21.0)	umol/L	Adult:>18_yrs_old	Both	Normal	Tietz Clinical Guide to Laboratory Tests 4th Ed., 2006.
Blood	3400.0 +/- 11900.0	umol/L	Adult:>18_yrs_old	Both	Normal	Wikipedia
Cerebrospinal_Fluid(CSF)	0 - 0.2	uM	Adult:>18_yrs_old	Both	Normal	Geigy scientific tables pp. 165-177. / edited by C. Lentner. 8th, rev. West Cadwell, N.J. : Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.


# Concentration_[Abnormal]:
Cerebrospinal_Fluid(CSF)	17.3 +/- 12.4	uM	Adult:>18_yrs_old	Both	Patients with cerebral vasospasm after subarachnoid hemorrhage	15789034 
Bile	5000 (4300-5700)	uM	Adult:>18_yrs_old	Both	Crohn's disease	16440420
Bile	2600 (2400-2800)	umol/L	Adult:>18_yrs_old	Both	Gallstone disease	16440420
Bile	4600 (3900-5300)	umol/L	Adult:>18_yrs_old	Both	Crohn's disease	16440420
Bile	5900 (4300-7500)	umol/L	Adult:>18_yrs_old	Both	Crohn's disease	16440420


# Associated_Disorders:
Colorectal Cancer; Coprostanic Acidemia; Crigler-Najjar Syndrome, Types I and II; Crohn's disease; Galactosemia; Gallstone disease; Glucose-6-Phosphate Dehydrogenase Deficiency (Favism); Glycogenosis, Type VII; Hyperbilirubinemia; Icterus; Intoxication Acetaminophen [DD]; Patients with cerebral vasospasm after subarachnoid hemorrhage; Progressive Familial Intrahepatic Cholestasis; Pyruvate Kinase Deficiency; Tarui Disease; Trihydroxycoprostanic Acidemia; Wilson Disease

# Pathway_Names:
Pentose and glucuronate interconversions;Androgen and estrogen metabolism;Starch and sucrose metabolism;Porphyrin and chlorophyll metabolism

# Pathway_Images:
;;;

# KEGG_Images:
map00040;map00150;map00500;map00860

# Pathway_Graphs:
;;;

# Pathway_SBMLs:
;;;

# Metabolic_Enzyme_1_ID:
5725

# Metabolic_Enzyme_1_Name:
UDP-glucuronosyltransferase 1-1 precursor

# Metabolic_Enzyme_1_Synonyms:
UDP- glucuronosyltransferase 1A1; UDPGT; UGT1*1; UGT1-01; UGT1.1; UGT- 1A; UGT1A; Bilirubin-specific UDPGT isozyme 1; HUG-BR1

# Metabolic_Enzyme_1_Gene_Name:
UGT1A1

# Metabolic_Enzyme_1_Protein_Sequence:
>UDPglucuronosyltransferase 11 precursor
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_1_Number_of_Residues:
533

# Metabolic_Enzyme_1_Molecular_Weight:
59592

# Metabolic_Enzyme_1_Theoretical_pI:
8.09

# Metabolic_Enzyme_1_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_1_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_1_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_1_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_1_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_1_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_1_Signals:
1-25

# Metabolic_Enzyme_1_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_1_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_1_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_1_GenBank_ID_Protein:
184473

# Metabolic_Enzyme_1_SwissProt_ID:
UD11_HUMAN (P22309)

# Metabolic_Enzyme_1_swissprot_Name:
Not Available

# Metabolic_Enzyme_1_Genecard_id:
UGT1A1

# Metabolic_Enzyme_1_Geneatlas_id:
UGT1A1

# Metabolic_Enzyme_1_hgnc_id:
HGNC:12530

# Metabolic_Enzyme_1_PDB_ID:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_1_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_1_Subcellular_Location:
Microsome

# Metabolic_Enzyme_1_Gene_Sequence:
>1602 bp
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_1_GenBank_ID_Gene:
M57899

# Metabolic_Enzyme_1_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_1_Locus:
2q37

# Metabolic_Enzyme_1_SNPs:
Not Available

# Metabolic_Enzyme_1_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413; 8226884; 7989045; 7989595; 7715297; 9621515; 9627603

# Metabolic_Enzyme_1_References:
Not Available

# Metabolic_Enzyme_2_ID:
5720

# Metabolic_Enzyme_2_Name:
UDP-glucuronosyltransferase 2B10 precursor

# Metabolic_Enzyme_2_Synonyms:
UDPGT

# Metabolic_Enzyme_2_Gene_Name:
UGT2B10

# Metabolic_Enzyme_2_Protein_Sequence:
>UDPglucuronosyltransferase 2B10 precursor
MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_2_Number_of_Residues:
528

# Metabolic_Enzyme_2_Molecular_Weight:
60775

# Metabolic_Enzyme_2_Theoretical_pI:
9.40

# Metabolic_Enzyme_2_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_2_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_2_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_2_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_2_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_2_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_2_Signals:
1-23

# Metabolic_Enzyme_2_Transmembrane_Regions:
492-512

# Metabolic_Enzyme_2_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_2_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_2_GenBank_ID_Protein:
516150

# Metabolic_Enzyme_2_SwissProt_ID:
UDB10_HUMAN (P36537)

# Metabolic_Enzyme_2_swissprot_Name:
Not Available

# Metabolic_Enzyme_2_Genecard_id:
UGT2B10

# Metabolic_Enzyme_2_Geneatlas_id:
UGT2B10

# Metabolic_Enzyme_2_hgnc_id:
HGNC:12544

# Metabolic_Enzyme_2_PDB_ID:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_2_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_2_Subcellular_Location:
Microsome

# Metabolic_Enzyme_2_Gene_Sequence:
>1587 bp
ATGGCTCTGAAATGGACTACAGTTCTGCTGATACAACTCAGTTTTTACTTTAGCTCTGGG
AGTTGTGGAAAGGTGCTGGTATGGGCCGCAGAATACAGCCTTTGGATGAATATGAAGACA
ATCCTGAAAGAACTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCTTCC
ATTCTTTTTGATCCCAACGACTCATCCACTCTTAAACTTGAAGTTTATCCTACATCTTTA
ACTAAAACTGAATTTGAGAATATCATCATGCAATTGGTTAAGAGATTGTCAGAAATTCAA
AAAGATACATTTTGGTTACCTTTTTCACAAGAACAAGAAATCCTGTGGGCAATTAATGAC
ATAATTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAACTTATGAAAAAACTACAA
GAGTCAAGATTTGACATCGTTTTTGCAGATGCTTATTTACCCTGTGGTGAGCTGCTGGCT
GAGCTATTTAACATACCCTTTGTGTACAGTCACAGCTTCAGTCCTGGCTACTCATTTGAA
AGGCACAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAAAATTA
AGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGCTCTATGTGCTTTATTTTGAC
TTTTGGTTCCAAATATTTAATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTAGGA
AGACCCACTACATTATCTGAGACAATGAGGAAAGCTGACATATGGCTTATGCGAAACTCC
TGGAATTTTAAATTTCCTCATCCATTCTTACCAAATGTTGATTTTGTTGGAGGACTCCAC
TGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGAGAA
AATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGGGCC
AACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTTTGGAGATTTGATGGG
AATAAACCAGATGCCTTAGGTCTCAATACTCGACTGTACAAGTGGATACCCCAGAATGAC
CTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATCTAT
GAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCTGAT
AATATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGAGTGGACTTCAACACAATGTCG
AGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAGAAT
ATTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCAGTC
TTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCCAAACATCTTCGAGTTGCAGCCCAC
AACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGCTTGTGTG
GCAACCGTGCTATTTATCATCACAAAGTGTTGTCTGTTTTGTTTCTGGAAGTTTGCTAGA
AAAGGAAAGAAGGGAAAAAGGGATTAG

# Metabolic_Enzyme_2_GenBank_ID_Gene:
X63359

# Metabolic_Enzyme_2_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_2_Locus:
4q13.2

# Metabolic_Enzyme_2_SNPs:
rs3208727; rs17146903; rs17146904; rs835313; rs835316; rs835309; rs861340; rs844342; rs1841042; rs294778; rs835311; rs2670431; rs294777; rs835317; rs7676529; rs835310; rs11726322; rs11249509; rs1968764; rs7676146; rs1849533; rs17146894; rs835314; rs294772; rs9917967; rs2054221; rs3792628; rs1849534; rs1913316; rs7657958; rs1913315; rs2926036; rs835312; rs1913317; rs4694343; rs835319; rs7673996; rs2670430; rs835315; rs4694344; rs1913318; rs7670334; rs1913320; rs11940320; rs294776; rs4694358; rs294775; rs1976666; rs4095564; rs9917968; rs2942857; rs4116824; rs3215212; rs28563143; rs1902931; rs13111730; rs12506094; rs1979281; rs11347207; rs34334121; rs12511664; rs5859144; rs5859145; rs13141448; rs4116823; rs28377589; rs35887929; rs36003814; rs34999460; rs7678703; rs9917930; rs35390620; rs1902932; rs7674011; rs6839369; rs10007687; rs4095563; rs5859146; rs1902930; rs13148664; rs33938096; rs13110924; rs5859147; rs7685333; rs28586884; rs10428371; rs294771; rs13132114; rs6839806; rs34291505; rs13131461; rs13132118; rs13114078; rs4116825; rs13111722; rs835318; rs17146905; rs34183546; rs35690388; rs11725502; rs35525464; rs11729424; rs11737566; rs11737644; rs1379809; rs1458232; rs1458233; rs294765; rs294770; rs4450999; rs4694340; rs6816491; rs6836993; rs6843220

# Metabolic_Enzyme_2_General_References:
8333863

# Metabolic_Enzyme_2_References:
Not Available

# Metabolic_Enzyme_3_ID:
5727

# Metabolic_Enzyme_3_Name:
UDP-glucuronosyltransferase 1-8 precursor

# Metabolic_Enzyme_3_Synonyms:
UDP- glucuronosyltransferase 1A8; UDPGT; UGT1*8; UGT1-08; UGT1.8; UGT- 1H; UGT1H

# Metabolic_Enzyme_3_Gene_Name:
UGT1A8

# Metabolic_Enzyme_3_Protein_Sequence:
>UDPglucuronosyltransferase 18 precursor
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_3_Number_of_Residues:
530

# Metabolic_Enzyme_3_Molecular_Weight:
59742

# Metabolic_Enzyme_3_Theoretical_pI:
7.73

# Metabolic_Enzyme_3_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_3_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_3_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_3_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_3_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_3_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_3_Signals:
1-25

# Metabolic_Enzyme_3_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_3_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_3_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_3_GenBank_ID_Protein:
2613044

# Metabolic_Enzyme_3_SwissProt_ID:
UD18_HUMAN (Q9HAW9)

# Metabolic_Enzyme_3_swissprot_Name:
Not Available

# Metabolic_Enzyme_3_Genecard_id:
UGT1A8

# Metabolic_Enzyme_3_Geneatlas_id:
UGT1A8

# Metabolic_Enzyme_3_hgnc_id:
HGNC:12540

# Metabolic_Enzyme_3_PDB_ID:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_3_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_3_Subcellular_Location:
Microsome

# Metabolic_Enzyme_3_Gene_Sequence:
>1593 bp
ATGGCTCGCACAGGGTGGACCAGCCCCATTCCCCTATGTGTTTCTCTGCTGCTGACCTGT
GGCTTTGCTGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAAATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCTGGACCGGGAATTCATGGATTTCGCCGATGCTCAATGGAAAGCA
CAAGTACGAAGTTTGTTTTCTCTATTTCTGAGTTCATCCAATGGTTTTTTTAACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAGATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCGGTGTTTCTTGATCCTTTTGATGCCTGTGCGTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATAGGTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
ATGGCTTTCAAGGAGAGAGTACGGAACCACATCTTGCACTTGGAGGAACATTTATTTTGC
CAGTATTTTTCCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTCACA
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACAGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_3_GenBank_ID_Gene:
AF030310

# Metabolic_Enzyme_3_Chromosome_Location:
Not Available

# Metabolic_Enzyme_3_Locus:
Not Available

# Metabolic_Enzyme_3_SNPs:
Not Available

# Metabolic_Enzyme_3_General_References:
9535849; 11434514; 12042666

# Metabolic_Enzyme_3_References:
Not Available

# Metabolic_Enzyme_4_ID:
5741

# Metabolic_Enzyme_4_Name:
UDP-glucuronosyltransferase 1-7 precursor

# Metabolic_Enzyme_4_Synonyms:
UDP- glucuronosyltransferase 1A7; UDPGT; UGT1*7; UGT1-07; UGT1.7; UGT- 1G; UGT1G

# Metabolic_Enzyme_4_Gene_Name:
UGT1A7

# Metabolic_Enzyme_4_Protein_Sequence:
>UDPglucuronosyltransferase 17 precursor
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF
FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_4_Number_of_Residues:
530

# Metabolic_Enzyme_4_Molecular_Weight:
59819

# Metabolic_Enzyme_4_Theoretical_pI:
7.85

# Metabolic_Enzyme_4_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_4_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_4_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_4_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_4_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_4_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_4_Signals:
1-25

# Metabolic_Enzyme_4_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_4_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_4_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_4_GenBank_ID_Protein:
2039360

# Metabolic_Enzyme_4_SwissProt_ID:
UD17_HUMAN (Q9HAW7)

# Metabolic_Enzyme_4_swissprot_Name:
Not Available

# Metabolic_Enzyme_4_Genecard_id:
UGT1A7

# Metabolic_Enzyme_4_Geneatlas_id:
UGT1A7

# Metabolic_Enzyme_4_hgnc_id:
HGNC:12539

# Metabolic_Enzyme_4_PDB_ID:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_4_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_4_Subcellular_Location:
Microsome

# Metabolic_Enzyme_4_Gene_Sequence:
>1593 bp
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGT
GGCTTTGCCAAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCA
TACACTCTGGAGGATCAGGACCGGGAGTTCATGGTTTTTGCCGATGCTCGCTGGACGGCA
CCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TGTTTTGATGCAGTGTTTCTCGATCCTTTTGATGCCTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCATGCACTTGGAGGAACATTTATTTTGC
CCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAG
TATCCCAAACCCGTGATGCCCAATATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCAGTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGCTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTTCAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_4_GenBank_ID_Gene:
U89507

# Metabolic_Enzyme_4_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_4_Locus:
2q37

# Metabolic_Enzyme_4_SNPs:
Not Available

# Metabolic_Enzyme_4_General_References:
9271343; 11434514; 11037804

# Metabolic_Enzyme_4_References:
Not Available

# Metabolic_Enzyme_5_ID:
5731

# Metabolic_Enzyme_5_Name:
UDP-glucuronosyltransferase 2B17 precursor

# Metabolic_Enzyme_5_Synonyms:
UDPGT; C19- steroid-specific UDP-glucuronosyltransferase

# Metabolic_Enzyme_5_Gene_Name:
UGT2B17

# Metabolic_Enzyme_5_Protein_Sequence:
>UDPglucuronosyltransferase 2B17 precursor
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD

# Metabolic_Enzyme_5_Number_of_Residues:
530

# Metabolic_Enzyme_5_Molecular_Weight:
61096

# Metabolic_Enzyme_5_Theoretical_pI:
8.73

# Metabolic_Enzyme_5_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_5_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_5_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3alpha,17beta-diol (3alpha-diol) > testosterone > androsterone (ADT)

# Metabolic_Enzyme_5_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_5_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_5_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_5_Signals:
1-23

# Metabolic_Enzyme_5_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_5_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_5_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_5_GenBank_ID_Protein:
3287473

# Metabolic_Enzyme_5_SwissProt_ID:
UDB17_HUMAN (O75795)

# Metabolic_Enzyme_5_swissprot_Name:
Not Available

# Metabolic_Enzyme_5_Genecard_id:
UGT2B17

# Metabolic_Enzyme_5_Geneatlas_id:
UGT2B17

# Metabolic_Enzyme_5_hgnc_id:
HGNC:12547

# Metabolic_Enzyme_5_PDB_ID:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_5_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_5_Subcellular_Location:
Microsome

# Metabolic_Enzyme_5_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG

# Metabolic_Enzyme_5_GenBank_ID_Gene:
U59209

# Metabolic_Enzyme_5_Chromosome_Location:
Not Available

# Metabolic_Enzyme_5_Locus:
Not Available

# Metabolic_Enzyme_5_SNPs:
Not Available

# Metabolic_Enzyme_5_General_References:
8798464; 9364925

# Metabolic_Enzyme_5_References:
Not Available

# Metabolic_Enzyme_6_ID:
5724

# Metabolic_Enzyme_6_Name:
UDP-glucuronosyltransferase 2A1 precursor

# Metabolic_Enzyme_6_Synonyms:
Not Available

# Metabolic_Enzyme_6_Gene_Name:
UGT2A1

# Metabolic_Enzyme_6_Protein_Sequence:
>UDPglucuronosyltransferase 2A1 precursor
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYKVPFGKERIEGVIKDFVSTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE

# Metabolic_Enzyme_6_Number_of_Residues:
527

# Metabolic_Enzyme_6_Molecular_Weight:
59873

# Metabolic_Enzyme_6_Theoretical_pI:
9.29

# Metabolic_Enzyme_6_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_6_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_6_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform is active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium

# Metabolic_Enzyme_6_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_6_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_6_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_6_Signals:
1-20

# Metabolic_Enzyme_6_Transmembrane_Regions:
491-507

# Metabolic_Enzyme_6_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_6_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_6_GenBank_ID_Protein:
4753766

# Metabolic_Enzyme_6_SwissProt_ID:
UDA1_HUMAN (Q9Y4X1)

# Metabolic_Enzyme_6_swissprot_Name:
Not Available

# Metabolic_Enzyme_6_Genecard_id:
UGT2A1

# Metabolic_Enzyme_6_Geneatlas_id:
UGT2A1

# Metabolic_Enzyme_6_hgnc_id:
HGNC:12542

# Metabolic_Enzyme_6_PDB_ID:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_6_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_6_Subcellular_Location:
Membrane

# Metabolic_Enzyme_6_Gene_Sequence:
>1584 bp
ATGTTAAACAACCTTCTGCTGTTCTCCCTTCAGATAAGTCTCATAGGAACCACTCTTGGT
GGGAATGTTTTGATTTGGCCAATGGAAGGTAGTCATTGGCTAAATGTTAAGATAATTATA
GATGAGCTCATTAAAAAGGAGCATAATGTGACTGTCCTAGTTGCCTCTGGTGCACTTTTC
ATCACACCAACCTCTAACCCATCTCTGACATTTGAAATATATAAGGTGCCCTTTGGCAAA
GAAAGAATAGAAGGAGTAATTAAGGACTTCGTTTCGACATGGCTGGAAAATAGACCATCT
CCTTCAACCATTTGGAGATTCTATCAGGAGATGGCCAAAGTAATCAAGGACTTCCACATG
GTGTCTCAGGAGATCTGTGATGGCGTTCTTAAAAACCAACAGCTGATGGCAAAGCTAAAG
AAAAGCAAGTTTGAAGTCCTGGTGTCTGATCCAGTATTTCCTTGTGGCGATATAGTAGCT
TTAAAACTTGGAATTCCATTTATGTACTCCTTGAGGTTTTCTCCAGCCTCAACAGTGGAA
AAGCACTGTGGGAAGGTACCATACCCTCCTTCCTATGTTCCTGCTGTTTTATCAGAACTC
ACCGACCAAATGTCTTTCACTGACAGAATAAGAAATTTCATCTCCTACCACCTACAGGAC
TACATGTTTGAAACTCTTTGGAAATCATGGGATTCATACTATAGTAAAGCTTTAGGAAGA
CCCACTACGTTATGTGAGACTATGGGGAAAGCTGAAATTTGGTTAATCCGAACATATTGG
GATTTTGAATTTCCTCGTCCATACTTACCTAATTTTGAGTTTGTTGGAGGATTGCACTGC
AAACCTGCCAAACCTTTACCTAAGGAAATGGAAGAATTTATCCAGAGCTCAGGTAAAAAT
GGTGTTGTGGTGTTTTCTCTGGGATCAATGGTCAAAAACCTTACAGAAGAAAAGGCCAAT
CTTATTGCCTCAGCCCTTGCCCAGATTCCACAGAAGGTTTTATGGAGATACAAAGGAAAG
AAACCAGCCACATTAGGAAACAATACTCAGCTCTTTGATTGGATACCCCAGAATGATCTT
CTTGGACATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAACTAATGGGATCTACGAA
GCTATTTACCACGGAGTCCCTATGGTGGGAGTTCCCATGTTTGCTGATCAGCCTGATAAC
ATTGCTCACATGAAGGCCAAAGGAGCAGCTGTGGAAGTGAACCTAAACACAATGACAAGT
GTGGATTTGCTTAGCGCTTTGAGAACAGTCATTAATGAACCTTCTTATAAAGAGAATGCT
ATGAGGTTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTGGATCGAGCAGTCTTC
TGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGGGTTGCAGCCCATGAC
CTCACCTGGTTCCAGTACCACTCTTTGGATGTAATTGGGTTCTTGCTGGTCTGTGTGACA
ACGGCTATATTTTTGGTCATACAATGTTGTTTGTTTTCCTGTCAAAAATTTGGTAAGATA
GGAAAGAAGAAAAAAAGAGAATAG

# Metabolic_Enzyme_6_GenBank_ID_Gene:
AJ006054

# Metabolic_Enzyme_6_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_6_Locus:
4q13

# Metabolic_Enzyme_6_SNPs:
rs4148301; rs4148304; rs2163659; rs7668703; rs1432329; rs1432332; rs7659937; rs7672805; rs979363; rs10000435; rs4148279; rs10028495; rs7656541; rs6835972; rs4148276; rs1432330; rs4148277; rs6600796; rs1821185; rs1432335; rs1432336; rs1319811; rs7671313; rs10903210; rs7689493; rs10013528; rs9992698; rs988671; rs6842466; rs6825253; rs4148291; rs11728546; rs2331685; rs2017370; rs4694225; rs6832424; rs6600793; rs1432324; rs1560605; rs2163658; rs4148308; rs4401516; rs6600794; rs988672; rs3775783; rs1036160; rs7655867; rs6854350; rs1835826; rs4148295; rs2288740; rs2288741; rs1438537; rs1432316; rs6853543; rs11249451; rs1158439; rs4148281; rs10001991; rs11946382; rs10518063; rs2033798; rs6600792; rs4048747; rs1432314; rs10033801; rs7676249; rs10026988; rs10028954; rs7662867; rs1432315; rs11249452; rs1835821; rs10006049; rs4148289; rs10011630; rs7662309; rs4148298; rs10021575; rs17147507; rs9999694; rs6846404; rs4694219; rs17147542; rs7692074; rs10023821; rs11933160; rs7662915; rs1967984; rs6855271; rs4148292; rs11249454; rs10033879; rs1432313; rs7685874; rs17147532; rs7665571; rs11736315; rs4473712; rs10023782; rs4694222; rs7670819; rs7699881; rs6824954; rs11936310; rs11936130; rs6600795; rs1432327; rs10011912; rs3822178; rs1835829; rs9999430; rs6848997; rs1835822; rs11942157; rs4148290; rs17674565; rs17674511; rs10004306; rs6811810; rs4148297; rs17618404; rs1583243; rs6858314; rs10012508; rs6832784; rs2217587; rs3775782; rs12507278; rs6855294; rs17147530; rs11731188; rs10009530; rs6824830; rs13129549; rs6831807; rs11736373; rs10006483; rs17618520; rs17680131; rs7680856; rs4148286; rs11931365; rs10023877; rs17618178; rs11722780; rs10027493; rs6826237; rs17147521; rs11249453; rs7688383; rs4148299; rs4148302; rs9997689; rs6814603; rs7681367; rs17674648; rs9917881; rs4148296; rs11721934; rs4148283; rs6849110; rs12501520; rs4148307; rs11736353; rs13120401; rs4550998; rs4148309; rs6839067; rs6852329; rs7670238; rs7668967; rs11946584; rs10022954; rs6832167; rs2010207; rs12500392; rs7690649; rs17617467; rs10013712; rs9993182; rs6846030; rs4148305; rs17618230; rs10026603; rs4694027; rs4148288; rs6831951; rs11730451; rs10005934; rs1897441; rs4395582; rs11729544; rs4148312; rs4280808; rs10518065; rs11929943; rs11929908; rs10033854; rs17147557; rs1550292; rs13134357; rs11939884; rs1432334; rs1432333; rs17619211; rs17681080; rs10471252; rs1347046; rs41292307; rs4148310; rs41292305; rs35926238; rs4148275; rs7674020; rs35816431; rs34251717; rs11438429; rs4148311; rs4694226; rs1368116; rs35378505; rs34607614; rs4148278; rs10649712; rs10682826; rs188964; rs11732515; rs192970; rs11725441; rs28448316; rs33924396; rs28798793; rs17147492; rs324309; rs28413749; rs17147503; rs17147534; rs28404221; rs6600791; rs28570072; rs33943659; rs34090224; rs35971542; rs11460578; rs33999522; rs11441625; rs11323266; rs35281757; rs7677083; rs28776197; rs28782228; rs35910775; rs10583998; rs12644575; rs1967983; rs34446108; rs34142192; rs28544323; rs4148294; rs35582043; rs189787; rs4148285; rs11931171; rs2033801; rs11319385; rs11279957; rs5859193; rs324313; rs4148282; rs33938194; rs7377236; rs34704021; rs36106673; rs28818211; rs28532778; rs34265777; rs4148303; rs13119853; rs36003863; rs1583242; rs34513233; rs985040; rs7686386; rs10691812; rs34650072; rs13112999; rs11721725; rs28759827; rs28726183; rs34028035; rs324310; rs4409023; rs4148320; rs13131759; rs33953975; rs17147520; rs36051343; rs35795947; rs7672793; rs36163528; rs34021488; rs11733854; rs11721681; rs7669007; rs13149874; rs4148322; rs36083211; rs34789624; rs35333044; rs28560222; rs7693686; rs34698455; rs4148306; rs7657761; rs34909158; rs5859194; rs34670944; rs35243459; rs34139484; rs35400584; rs28689093; rs188966; rs11946796; rs11947056; rs11733907; rs28568390; rs34647023; rs10010846; rs6813494; rs7698372; rs28716091; rs10023818; rs35302832; rs34810925; rs34370025; rs4148313; rs4148287; rs34213902; rs35487350; rs35071017; rs10569499; rs33913173; rs28522985; rs34858243; rs28556671; rs34208726; rs34396917; rs4148284; rs11728785; rs28560191; rs28513556; rs28508252; rs36191379; rs4148316; rs4148280; rs4148293; rs7668214; rs2877457; rs34817437; rs2116564; rs11940905; rs10017134; rs28528833; rs35101874; rs33976214; rs34975164; rs34590689; rs34452487; rs2043241; rs3074345; rs35227598; rs34012364; rs34002846; rs28744454; rs34078716; rs34062331; rs5859195; rs35000204; rs33992705; rs10031145; rs33924614; rs11937993; rs13115454; rs1347047; rs1432317; rs1835830; rs4333255; rs6810459; rs7671030; rs7671041; rs7674562; rs7694939; rs9329029; rs9996459

# Metabolic_Enzyme_6_General_References:
10359671

# Metabolic_Enzyme_6_References:
Not Available

# Metabolic_Enzyme_7_ID:
5719

# Metabolic_Enzyme_7_Name:
UDP-glucuronosyltransferase 1-4 precursor

# Metabolic_Enzyme_7_Synonyms:
UDP- glucuronosyltransferase 1A4; UDPGT; UGT1*4; UGT1-04; UGT1.4; UGT- 1D; UGT1D; Bilirubin-specific UDPGT isozyme 2; HUG-BR2

# Metabolic_Enzyme_7_Gene_Name:
UGT1A4

# Metabolic_Enzyme_7_Protein_Sequence:
>UDPglucuronosyltransferase 14 precursor
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV
LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV
SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL
DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ
REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_7_Number_of_Residues:
534

# Metabolic_Enzyme_7_Molecular_Weight:
60026

# Metabolic_Enzyme_7_Theoretical_pI:
8.68

# Metabolic_Enzyme_7_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_7_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_7_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate

# Metabolic_Enzyme_7_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_7_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_7_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_7_Signals:
1-28

# Metabolic_Enzyme_7_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_7_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_7_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_7_GenBank_ID_Protein:
340137

# Metabolic_Enzyme_7_SwissProt_ID:
UD14_HUMAN (P22310)

# Metabolic_Enzyme_7_swissprot_Name:
Not Available

# Metabolic_Enzyme_7_Genecard_id:
UGT1A4

# Metabolic_Enzyme_7_Geneatlas_id:
UGT1A4

# Metabolic_Enzyme_7_hgnc_id:
HGNC:12536

# Metabolic_Enzyme_7_PDB_ID:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_7_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_7_Subcellular_Location:
Microsome

# Metabolic_Enzyme_7_Gene_Sequence:
>867 bp
ATGGCCAGAGGACTCCAGGTTCCCCTGCCGCGGCTGGCCACAGGACTGCTGCTCCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCACTGATGGCAGCCCC
TGGCTCAGCATGCGGGAGGCCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCGGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAAATTTTTCACCCTGACAGCCTAT
GCTGTTCCATGGACCCAGAAGGAATTTGATCGCGTTACGCTGGGCTACACTCAAGGGTTC
TTTGAAACAGAACATCTTCTGAAGAGATATTCTAGAAGTATGGCAATTATGAACAATGTA
TCTTTGGCCCTTCATAGGTGTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGTGGGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTTTGGAGGTACATTCCATGTGACTTA
GACTTTAAGGGCACACAGTGTCCAAATCCTTCCTCCTATATTCCTAAGTTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATACTTTTTCTGCCCCTTATGCAAGTCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCTATGCATCCGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_7_GenBank_ID_Gene:
M84128

# Metabolic_Enzyme_7_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_7_Locus:
2q37

# Metabolic_Enzyme_7_SNPs:
Not Available

# Metabolic_Enzyme_7_General_References:
1898728; 1339448; 11434514; 1634050; 8280139; 8276413

# Metabolic_Enzyme_7_References:
Not Available

# Metabolic_Enzyme_8_ID:
5726

# Metabolic_Enzyme_8_Name:
UDP-glucuronosyltransferase 1-9 precursor

# Metabolic_Enzyme_8_Synonyms:
UDP- glucuronosyltransferase 1A9; UDPGT; UGT1*9; UGT1-9; UGT1.9; UGT- 1I; UGT1I; lugP4

# Metabolic_Enzyme_8_Gene_Name:
UGT1A9

# Metabolic_Enzyme_8_Protein_Sequence:
>UDPglucuronosyltransferase 19 precursor
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP
EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF
FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG
AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT
EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_8_Number_of_Residues:
530

# Metabolic_Enzyme_8_Molecular_Weight:
59942

# Metabolic_Enzyme_8_Theoretical_pI:
7.96

# Metabolic_Enzyme_8_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_8_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_8_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_8_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_8_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_8_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_8_Signals:
1-25

# Metabolic_Enzyme_8_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_8_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_8_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_8_GenBank_ID_Protein:
7690346

# Metabolic_Enzyme_8_SwissProt_ID:
UD19_HUMAN (O60656)

# Metabolic_Enzyme_8_swissprot_Name:
Not Available

# Metabolic_Enzyme_8_Genecard_id:
UGT1A9

# Metabolic_Enzyme_8_Geneatlas_id:
UGT1A9

# Metabolic_Enzyme_8_hgnc_id:
HGNC:12541

# Metabolic_Enzyme_8_PDB_ID:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_8_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_8_Subcellular_Location:
Microsome

# Metabolic_Enzyme_8_Gene_Sequence:
>1593 bp
ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
GGCTTTGCCGAGGCAGGGAAGCTAGTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCAGTGCC
AGAGGTGAGTTGGCAACTGGGAAGATCAATGAATTGCACAGTGAAGACTTATTCAACTTC
ATATACCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGAC
ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATGAGAGG
AAAGCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GGTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATGC
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCAGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCATGAATGTTCTGGAAATGACTTCTGAAGAATTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTTATGAGGCACAAGGGCGCGACACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGCCGTGCTGACAGTGGCC
TTCATCACCTGTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_8_GenBank_ID_Gene:
S55985

# Metabolic_Enzyme_8_Chromosome_Location:
Not Available

# Metabolic_Enzyme_8_Locus:
Not Available

# Metabolic_Enzyme_8_SNPs:
Not Available

# Metabolic_Enzyme_8_General_References:
1910331; 11434514

# Metabolic_Enzyme_8_References:
Not Available

# Metabolic_Enzyme_9_ID:
5722

# Metabolic_Enzyme_9_Name:
UDP-glucuronosyltransferase 2B15 precursor

# Metabolic_Enzyme_9_Synonyms:
UDPGT; UDPGTh-3; HLUG4

# Metabolic_Enzyme_9_Gene_Name:
UGT2B15

# Metabolic_Enzyme_9_Protein_Sequence:
>UDPglucuronosyltransferase 2B15 precursor
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSA
STLVNASKSSAIKLEVYPTSLTKNDLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEY
YDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYT
FEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD

# Metabolic_Enzyme_9_Number_of_Residues:
530

# Metabolic_Enzyme_9_Molecular_Weight:
60989

# Metabolic_Enzyme_9_Theoretical_pI:
9.04

# Metabolic_Enzyme_9_GO_Classification:
Not Available

# Metabolic_Enzyme_9_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_9_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens

# Metabolic_Enzyme_9_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_9_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_9_Pfam_Domain_Function:
Not Available

# Metabolic_Enzyme_9_Signals:
1-23

# Metabolic_Enzyme_9_Transmembrane_Regions:
495-515

# Metabolic_Enzyme_9_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_9_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_9_GenBank_ID_Protein:
23955933

# Metabolic_Enzyme_9_SwissProt_ID:
UDB15_HUMAN (P54855)

# Metabolic_Enzyme_9_swissprot_Name:
Not Available

# Metabolic_Enzyme_9_Genecard_id:
UGT2B15

# Metabolic_Enzyme_9_Geneatlas_id:
UGT2B15

# Metabolic_Enzyme_9_hgnc_id:
HGNC:12546

# Metabolic_Enzyme_9_PDB_ID:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_9_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_9_Subcellular_Location:
Microsome

# Metabolic_Enzyme_9_Gene_Sequence:
>1593 bp
ATGTCTCTGAAATGGACGTCAGTCTTTCTGCTGATACAGCTCAGTTGTTACTTTAGCTCT
GGAAGCTGTGGAAAGGTGCTAGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGACTGTGTTGACATCTTCGGCT
TCTACTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTCTCTTCTGAAAATTCTCGATAGATGGATATATGGT
GTTTCAAAAAATACATTTTGGTCATATTTTTCACAATTACAAGAATTGTGTTGGGAATAT
TATGACTACAGTAACAAGCTCTGTAAAGATGCAGTTTTGAATAAGAAACTTATGATGAAA
CTACAAGAGTCAAAGTTTGATGTCATTCTGGCAGATGCCCTTAATCCCTGTGGTGAGCTA
CTGGCTGAACTATTTAACATACCCTTTCTGTACAGTCTTCGATTCTCTGTTGGCTACACA
TTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATACATATGCTTTAT
TTTGACTTTTGGTTTCAAATTTATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCCTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTACAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTGTCTATAAA
GAGAATGTCATGAAATTATCAAGAATTCATCATGACCAACCAATGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTTCGAGTCGCA
GCTCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTGTGATATTTATCATCACAAAATTTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGAGATTAG

# Metabolic_Enzyme_9_GenBank_ID_Gene:
AF548389

# Metabolic_Enzyme_9_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_9_Locus:
4q13

# Metabolic_Enzyme_9_SNPs:
rs6825560; rs988562; rs1120265; rs1960773; rs7686914; rs988560; rs6839555; rs7682027; rs3100; rs9994887; rs1580083; rs7377952; rs7696472; rs6825748; rs13128530; rs1968719; rs1968718; rs7654523; rs1026337; rs1947435; rs1026338; rs2278917; rs1160212; rs12500760; rs4048844; rs7377954; rs12647504; rs4148271; rs2168050; rs2168051; rs6858676; rs35791822; rs13112099; rs7377950; rs34930215; rs17324486; rs5017546; rs2877378; rs1947434; rs5017549; rs17221777; rs35601514; rs6839657; rs11371462; rs5017544; rs2331421; rs2331422; rs6820752; rs4694747; rs12108552; rs34214136; rs4426857; rs35503231; rs5017548; rs35397066; rs5859136; rs2877377; rs10549990; rs2331423; rs5017545; rs34618890; rs5017547; rs5029385; rs1026339; rs5859137; rs34498614; rs34207963; rs3966095; rs1902023; rs4148269

# Metabolic_Enzyme_9_General_References:
7835232; 9295060; 2116769

# Metabolic_Enzyme_9_References:
Not Available

# Metabolic_Enzyme_10_ID:
5734

# Metabolic_Enzyme_10_Name:
UDP-glucuronosyltransferase 2B11 precursor

# Metabolic_Enzyme_10_Synonyms:
UDPGT

# Metabolic_Enzyme_10_Gene_Name:
UGT2B11

# Metabolic_Enzyme_10_Protein_Sequence:
>UDPglucuronosyltransferase 2B11 precursor
MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELY
DIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTI
ERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTM
SSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_10_Number_of_Residues:
529

# Metabolic_Enzyme_10_Molecular_Weight:
61039

# Metabolic_Enzyme_10_Theoretical_pI:
9.29

# Metabolic_Enzyme_10_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_10_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_10_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_10_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_10_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_10_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_10_Signals:
1-21

# Metabolic_Enzyme_10_Transmembrane_Regions:
493-513

# Metabolic_Enzyme_10_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_10_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_10_GenBank_ID_Protein:
3360273

# Metabolic_Enzyme_10_SwissProt_ID:
UDB11_HUMAN (O75310)

# Metabolic_Enzyme_10_swissprot_Name:
Not Available

# Metabolic_Enzyme_10_Genecard_id:
UGT2B11

# Metabolic_Enzyme_10_Geneatlas_id:
UGT2B11

# Metabolic_Enzyme_10_hgnc_id:
HGNC:12545

# Metabolic_Enzyme_10_PDB_ID:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_10_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_10_Subcellular_Location:
Microsome

# Metabolic_Enzyme_10_Gene_Sequence:
>1590 bp
ATGACTCTGAAATGGACTTCAGTTCTTCTGCTGATACATCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAAGTGCTGGTGTGGGCCGCAGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGATGCATCCACTCTTAAATTTGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CGAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTATAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCGTTTTTGCAGATGCTGTTTTTCCCTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACGGTTTGTGTACAGTCTCCGCTTTACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTATTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTCTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGAAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACGTTGATTTTGTTGGAGGATTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAGTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAATGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAC
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTGGGCATTCCATTGTTTTTTGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGATTGGACTTCAACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATATTATGAAATTATCAAGAATTCAACATGATCAACCAGTAAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCCCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CATGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTATCATCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_10_GenBank_ID_Gene:
AF016492

# Metabolic_Enzyme_10_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_10_Locus:
4q13.2

# Metabolic_Enzyme_10_SNPs:
rs4694697; rs4415023; rs4400059; rs4543201; rs4283741; rs11945946; rs7436729; rs11947293; rs4463131; rs6833028; rs12500268; rs4608875; rs7688262; rs7697037; rs3890590; rs7697482; rs35248576; rs11340393; rs5859168; rs4485863; rs28743034; rs4619960; rs13148581; rs13113479; rs4406085; rs34519957; rs13119196; rs28561592; rs4406086; rs13134572; rs7660257; rs13148525; rs35902951; rs13148376; rs4386666; rs13134364; rs13113695; rs4485864; rs13107183; rs7660248; rs13119170; rs13103028; rs13134363; rs35555504; rs13139597; rs35443238; rs28470680; rs13113271; rs13119197; rs13107219; rs10007587; rs4466107; rs10434518; rs34416320; rs10007579; rs6847476; rs10012181; rs9996390; rs12502502; rs13123057; rs4526045; rs4694199; rs6817250; rs6825376; rs7672567; rs7682460; rs7695331

# Metabolic_Enzyme_10_General_References:
9675083

# Metabolic_Enzyme_10_References:
Not Available

# Metabolic_Enzyme_11_ID:
5728

# Metabolic_Enzyme_11_Name:
UDP-glucuronosyltransferase 1-3 precursor

# Metabolic_Enzyme_11_Synonyms:
UDP- glucuronosyltransferase 1A3; UDPGT; UGT1*3; UGT1-03; UGT1.3; UGT- 1C; UGT1C

# Metabolic_Enzyme_11_Gene_Name:
UGT1A3

# Metabolic_Enzyme_11_Protein_Sequence:
>UDPglucuronosyltransferase 13 precursor
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVV
LTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM
SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQ
REVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_11_Number_of_Residues:
534

# Metabolic_Enzyme_11_Molecular_Weight:
60339

# Metabolic_Enzyme_11_Theoretical_pI:
8.28

# Metabolic_Enzyme_11_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_11_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_11_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_11_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_11_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_11_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_11_Signals:
1-28

# Metabolic_Enzyme_11_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_11_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_11_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_11_GenBank_ID_Protein:
340135

# Metabolic_Enzyme_11_SwissProt_ID:
UD13_HUMAN (P35503)

# Metabolic_Enzyme_11_swissprot_Name:
Not Available

# Metabolic_Enzyme_11_Genecard_id:
UGT1A3

# Metabolic_Enzyme_11_Geneatlas_id:
UGT1A3

# Metabolic_Enzyme_11_hgnc_id:
HGNC:12535

# Metabolic_Enzyme_11_PDB_ID:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_11_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_11_Subcellular_Location:
Microsome

# Metabolic_Enzyme_11_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGTGGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGAAAGGTGTTGGTGGTGCCCATTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGTCTTGCGGGAGCTCCATGCCAGAGGCCACCAGGCAGTGGTC
CTCACCCCAGAGGTGAATATGCACATCAAAGAAGAGAACTTTTTCACCCTGACAACCTAT
GCCATTTCGTGGACCCAGGATGAATTTGATCGCCATGTGCTGGGCCACACTCAACTGTAC
TTTGAAACAGAACATTTTCTGAAGAAATTTTTCAGAAGTATGGCAATGTTGAACAATATG
TCTTTGGTCTATCATAGGTCTTGTGTGGAGCTACTACATAATGAGGCCCTGATCAGGCAC
CTGAATGCTACTTCCTTTGATGTGGTTTTAACAGACCCCGTTAACCTCTGCGCGGCAGTG
CTGGCTAAGTACCTGTCGATTCCTACTGTGTTTTTTTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACAACC
AATTCAGACCACATGACATTCATGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACATTTGCCATGCTTTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATATTCTCAGTCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGACTACCCCAGGCCAATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACAGGAAGCCACTATCTCAG

# Metabolic_Enzyme_11_GenBank_ID_Gene:
M84127

# Metabolic_Enzyme_11_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_11_Locus:
2q37

# Metabolic_Enzyme_11_SNPs:
Not Available

# Metabolic_Enzyme_11_General_References:
1339448; 11434514

# Metabolic_Enzyme_11_References:
Not Available

# Metabolic_Enzyme_12_ID:
5732

# Metabolic_Enzyme_12_Name:
UDP-glucuronosyltransferase 1-6 precursor

# Metabolic_Enzyme_12_Synonyms:
UDP- glucuronosyltransferase 1A6; UDPGT; UGT1*6; UGT1-06; UGT1.6; UGT- 1F; UGT1F; Phenol-metabolizing UDP-glucuronosyltransferase

# Metabolic_Enzyme_12_Gene_Name:
UGT1A6

# Metabolic_Enzyme_12_Protein_Sequence:
>UDPglucuronosyltransferase 16 precursor
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV
PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG
LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH
TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRD
VDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHG
IVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL
GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE
DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDL
TWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_12_Number_of_Residues:
532

# Metabolic_Enzyme_12_Molecular_Weight:
60751

# Metabolic_Enzyme_12_Theoretical_pI:
8.55

# Metabolic_Enzyme_12_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_12_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_12_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols

# Metabolic_Enzyme_12_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_12_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_12_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_12_Signals:
1-26

# Metabolic_Enzyme_12_Transmembrane_Regions:
490-506

# Metabolic_Enzyme_12_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_12_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_12_GenBank_ID_Protein:
340141

# Metabolic_Enzyme_12_SwissProt_ID:
UD16_HUMAN (P19224)

# Metabolic_Enzyme_12_swissprot_Name:
Not Available

# Metabolic_Enzyme_12_Genecard_id:
UGT1A6

# Metabolic_Enzyme_12_Geneatlas_id:
UGT1A6

# Metabolic_Enzyme_12_hgnc_id:
HGNC:12538

# Metabolic_Enzyme_12_PDB_ID:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_12_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_12_Subcellular_Location:
Microsome

# Metabolic_Enzyme_12_Gene_Sequence:
>861 bp
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAG

# Metabolic_Enzyme_12_GenBank_ID_Gene:
M84130

# Metabolic_Enzyme_12_Chromosome_Location:
Not Available

# Metabolic_Enzyme_12_Locus:
Not Available

# Metabolic_Enzyme_12_SNPs:
Not Available

# Metabolic_Enzyme_12_General_References:
1339448; 3141926; 11434514; 9466822; 9429234

# Metabolic_Enzyme_12_References:
Not Available

# Metabolic_Enzyme_13_ID:
5733

# Metabolic_Enzyme_13_Name:
UDP-glucuronosyltransferase 1-5 precursor

# Metabolic_Enzyme_13_Synonyms:
UDP- glucuronosyltransferase 1A5; UDPGT; UGT1*5; UGT1-05; UGT1.5; UGT- 1E; UGT1E

# Metabolic_Enzyme_13_Gene_Name:
UGT1A5

# Metabolic_Enzyme_13_Protein_Sequence:
>UDPglucuronosyltransferase 15 precursor
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVV
LTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNM
SLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDL
DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQ
REVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND
LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT
SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH
DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_13_Number_of_Residues:
534

# Metabolic_Enzyme_13_Molecular_Weight:
60072

# Metabolic_Enzyme_13_Theoretical_pI:
8.14

# Metabolic_Enzyme_13_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_13_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_13_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_13_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_13_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_13_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_13_Signals:
1-28

# Metabolic_Enzyme_13_Transmembrane_Regions:
492-508

# Metabolic_Enzyme_13_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_13_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_13_GenBank_ID_Protein:
340139

# Metabolic_Enzyme_13_SwissProt_ID:
UD15_HUMAN (P35504)

# Metabolic_Enzyme_13_swissprot_Name:
Not Available

# Metabolic_Enzyme_13_Genecard_id:
UGT1A5

# Metabolic_Enzyme_13_Geneatlas_id:
UGT1A5

# Metabolic_Enzyme_13_hgnc_id:
HGNC:12537

# Metabolic_Enzyme_13_PDB_ID:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_13_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_13_Subcellular_Location:
Microsome

# Metabolic_Enzyme_13_Gene_Sequence:
>867 bp
ATGGCCACAGGACTCCAGGTTCCCCTGCCGCAGCTGGCCACAGGACTGCTGCTTCTCCTC
AGTGTCCAGCCCTGGGCTGAGAGTGGGAAGGTGCTGGTGGTGCCCACTGATGGCAGCCAC
TGGCTCAGCATGCGGGAGGCCTTGCGGGACCTCCATGCGAGAGGCCACCAGGTGGTGGTC
CTCACCCTGGAGGTGAATATGTACATCAAAGAAGAGAACTTTTTCACCCTGACAACGTAT
GCCATTTCATGGACCCAGGACGAATTTGATCGCCTTTTGCTGGGTCACACTCAATCGTTC
TTTGAAACAGAACATCTTCTGATGAAATTTTCTAGAAGAATGGCAATTATGAACAATATG
TCTTTGATCATACATAGGTCTTGTGTGGAGCTACTGCATAATGAGGCCCTGATCAGGCAC
CTGCATGCTACTTCCTTTGATGTGGTTCTAACAGACCCCTTTCACCTCTGCGCGGCGGTG
CTGGCTAAGTACCTGTCGATTCCTGCTGTGTTTTTCTTGAGGAACATTCCATGTGATTTA
GACTTTAAGGGCACACAGTGTCCAAACCCTTCCTCCTATATTCCTAGATTACTAACGACC
AATTCAGACCACATGACATTCCTGCAAAGGGTCAAGAACATGCTCTACCCTCTGGCCCTG
TCCTACCTTTGCCATGCTGTTTCTGCTCCTTATGCAAGCCTTGCCTCTGAGCTTTTTCAG
AGAGAGGTGTCAGTGGTGGATCTTGTCAGCCATGCATCTGTGTGGCTGTTCCGAGGGGAC
TTTGTGATGGATTACCCCAGGCCGATCATGCCCAACATGGTCTTCATTGGGGGCATCAAC
TGTGCCAACGGGAAGCCACTATCTCAG

# Metabolic_Enzyme_13_GenBank_ID_Gene:
M84129

# Metabolic_Enzyme_13_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_13_Locus:
2q37

# Metabolic_Enzyme_13_SNPs:
Not Available

# Metabolic_Enzyme_13_General_References:
1339448; 11434514

# Metabolic_Enzyme_13_References:
Not Available

# Metabolic_Enzyme_14_ID:
5973

# Metabolic_Enzyme_14_Name:
Biliverdin reductase A precursor

# Metabolic_Enzyme_14_Synonyms:
Biliverdin-IX alpha- reductase; BVR A

# Metabolic_Enzyme_14_Gene_Name:
BLVRA

# Metabolic_Enzyme_14_Protein_Sequence:
>Biliverdin reductase A precursor
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE
DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV
LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF
GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN
VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK

# Metabolic_Enzyme_14_Number_of_Residues:
296

# Metabolic_Enzyme_14_Molecular_Weight:
33429

# Metabolic_Enzyme_14_Theoretical_pI:
6.41

# Metabolic_Enzyme_14_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  generation of precursor metabolites and energy
Process:  electron transport
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_14_General_Function:
Not Available

# Metabolic_Enzyme_14_Specific_Function:
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor

# Metabolic_Enzyme_14_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_14_Reaction:
bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+

# Metabolic_Enzyme_14_Pfam_Domain_Function:
PF09166:Biliv-reduc_cat;
PF01408:GFO_IDH_MocA

# Metabolic_Enzyme_14_Signals:
None

# Metabolic_Enzyme_14_Transmembrane_Regions:
None

# Metabolic_Enzyme_14_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_14_EC_Link:
EC 1.3.1.24

# Metabolic_Enzyme_14_GenBank_ID_Protein:
1246749

# Metabolic_Enzyme_14_SwissProt_ID:
BIEA_HUMAN (P53004)

# Metabolic_Enzyme_14_swissprot_Name:
Not Available

# Metabolic_Enzyme_14_Genecard_id:
BLVRA

# Metabolic_Enzyme_14_Geneatlas_id:
BLVRA

# Metabolic_Enzyme_14_hgnc_id:
HGNC:1062

# Metabolic_Enzyme_14_PDB_ID:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_14_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_14_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_14_Gene_Sequence:
>891 bp
ATGAATGCAGAGCCCGAGAGGAAGTTTGGCGTGGTGGTGGTTGGTGTTGGCCGAGCCGGC
TCCGTGCGGATGAGGGACTTGCGGAATCCACACCCTTCCTCAGCGTTCCTGAACCTGATT
GGCTTCGTGTCGAGAAGGGAGCTCGGGAGCATTGATGGAGTCCAGCAGATTTCTTTGGAG
GATGCTCTTTCCAGCCAAGAGGTGGAGGTCGCCTATATCTGCAGTGAGAGCTCCAGCCAT
GAGGACTACATCAGGCAGTTCCTTAATGCTGGCAAGCACGTCCTTGTGGAATACCCCATG
ACACTGTCATTGGCGGCCGCTCAGGAACTGTGGGAGCTGGCTGAGCAGAAAGGAAAAGTC
TTGCACGAGGAGCATGTTGAACTCTTGATGGAGGAATTCGCTTTCCTGAAAAAAGAAGTG
GTGGGGAAAGACCTGCTGAAAGGGTCGCTCCTCTTCACATCTGACCCGTTGGAAGAAGAC
CGGTTTGGCTTCCCTGCATTCAGCGGCATCTCTCGACTGACCTGGCTGGTCTCCCTCTTT
GGGGAGCTTTCTCTTGTGTCTGCCACTTTGGAAGAGCGAAAGGAAGATCAGTATATGAAA
ATGACAGTGTGTCTGGAGACAGAGAAGAAAAGTCCACTGTCATGGATTGAAGAAAAAGGA
CCTGGTCTAAAACGAAACAGATATTTAAGCTTCCATTTCAAGTCTGGGTCCTTGGAGAAT
GTGCCAAATGTAGGAGTGAATAAGAACATATTTCTGAAAGATCAAAATATATTTGTCCAG
AAACTCTTGGGCCAGTTCTCTGAGAAGGAACTGGCTGCTGAAAAGAAACGCATCCTGCAC
TGCCTGGGGCTTGCAGAAGAAATCCAGAAATATTGCTGTTCAAGGAAGTAA

# Metabolic_Enzyme_14_GenBank_ID_Gene:
X93086

# Metabolic_Enzyme_14_Chromosome_Location:
Chromosome:7

# Metabolic_Enzyme_14_Locus:
7p14-cen

# Metabolic_Enzyme_14_SNPs:
rs699512; rs1050916; rs17245918; rs7738; rs9632617; rs1131372; rs849184; rs699510; rs1181574; rs10245471; rs4724242; rs10225380; rs699511; rs1181573; rs1637532; rs10486752; rs2302032; rs10233867; rs7803741; rs7783986; rs7784427; rs7804430; rs7784710; rs7804638; rs10225808; rs7803722; rs17239460; rs2330921; rs7788416; rs7793236; rs17245841; rs7784666; rs10260060; rs7784876; rs7805033; rs7784790; rs7785115; rs10233888; rs6972339; rs10229363; rs2246171; rs2877262; rs849165; rs2282922; rs10229520; rs2730625; rs849163; rs2330952; rs1306742; rs3094951; rs849162; rs1317916; rs849161; rs1181576; rs2074795; rs3107888; rs17246016; rs11982143; rs10244587; rs17245981; rs849185; rs2690381; rs10268054; rs1181572; rs10234057; rs3107889; rs2299149; rs17239727; rs11306210; rs17239601; rs10695215; rs10280853; rs17246086; rs17239608; rs17239537; rs17245946; rs1181577; rs6978907; rs17245869; rs17246002; rs17245932; rs17246100; rs7785330; rs17246121; rs17239558; rs17239678; rs17239565; rs17239685; rs10254271; rs17239657; rs17239523; rs17239664; rs17246135; rs10250951; rs17239509; rs17239713; rs2158952; rs11973765; rs17239572; rs17239671; rs17239544; rs17239692; rs12673217; rs3094952; rs17246065; rs10240388; rs1799077; rs17245785; rs1637530; rs17239409; rs17856154; rs17245911; rs17850330; rs1802849; rs34027937; rs17245834; rs34953729; rs17239423; rs11419474; rs34085711; rs7805389; rs2690385; rs13222245; rs7805153; rs2730631; rs10583379; rs28707680; rs17239432; rs17245799; rs13222143; rs2730630; rs36008307; rs11760630; rs34298554; rs6966862; rs34787806; rs17239439; rs13241746; rs13222507; rs6951295; rs17245827; rs34256119; rs34361520; rs849183; rs34892644; rs2690384; rs34000003; rs4580947; rs36184743; rs36137441; rs17245897; rs17239495; rs2730606; rs17239622; rs28793411; rs35792323; rs3965475; rs35238622; rs17245876; rs17245883; rs17246023; rs36198504; rs17246072; rs35572942; rs36155448; rs36065452; rs17246044; rs34278744; rs17245925; rs17239481; rs17246009; rs17239720; rs17239530; rs34850514; rs5883874; rs13223183; rs36200736; rs12386638; rs28662150; rs10255811; rs28697916; rs36156479; rs17246114; rs1181575; rs17245890; rs13307958; rs34234974; rs17245988; rs35149435; rs17246030; rs5883875; rs28856095; rs1306743; rs35816005; rs34519492; rs36121270; rs34828844; rs35798806; rs17245939; rs17239516; rs1859871; rs17239628; rs36184468; rs17239615; rs34011643; rs17239593; rs10701241; rs28458462; rs17239488; rs34583169; rs34404101; rs36198252; rs17245967; rs36191968; rs35592453; rs1859872; rs6953918; rs17245974; rs36199636; rs11983551; rs10272931; rs849164; rs36200068; rs17245855; rs17245862; rs3063069; rs13241202; rs2529585; rs17239741; rs35579130; rs9692130; rs17245764; rs17239416; rs1637531; rs10650484; rs17239382; rs10665152; rs11767476; rs33964150; rs17239396; rs17239402; rs35368902; rs17245778; rs10227643; rs1181597; rs1181598; rs1181599; rs1181600; rs1181601; rs1181602; rs1181603; rs12672084; rs2529584; rs589570; rs645853; rs730584; rs734353

# Metabolic_Enzyme_14_General_References:
8631357; 12853948; 8424666; 7929092

# Metabolic_Enzyme_14_References:
Not Available

# Metabolic_Enzyme_15_ID:
5696

# Metabolic_Enzyme_15_Name:
UDP-glucuronosyltransferase 2B4 precursor

# Metabolic_Enzyme_15_Synonyms:
UDPGT; Hyodeoxycholic acid; HLUG25; UDPGTh-1

# Metabolic_Enzyme_15_Gene_Name:
UGT2B4

# Metabolic_Enzyme_15_Protein_Sequence:
>UDPglucuronosyltransferase 2B4 precursor
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSA
SISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFN
DILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAI
EKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVL
GRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTM
SSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD

# Metabolic_Enzyme_15_Number_of_Residues:
528

# Metabolic_Enzyme_15_Molecular_Weight:
60513

# Metabolic_Enzyme_15_Theoretical_pI:
8.75

# Metabolic_Enzyme_15_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_15_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_15_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

# Metabolic_Enzyme_15_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_15_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_15_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_15_Signals:
1-23

# Metabolic_Enzyme_15_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_15_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_15_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_15_GenBank_ID_Protein:
37589

# Metabolic_Enzyme_15_SwissProt_ID:
UDB4_HUMAN (P06133)

# Metabolic_Enzyme_15_swissprot_Name:
Not Available

# Metabolic_Enzyme_15_Genecard_id:
UGT2B4

# Metabolic_Enzyme_15_Geneatlas_id:
UGT2B4

# Metabolic_Enzyme_15_hgnc_id:
HGNC:12553

# Metabolic_Enzyme_15_PDB_ID:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_15_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_15_Subcellular_Location:
Microsome

# Metabolic_Enzyme_15_Gene_Sequence:
>1587 bp
ATGTCTATGAAATGGACTTCAGCTCTTCTGCTGATACAGCTGAGCTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATTCAGCCACTGGATGAATATAAAG
ACAATCCTGGATGAACTTGTCCAGAGAGGTCATGAGGTGACTGTATTGGCATCTTCAGCT
TCCATTTCTTTCGATCCCAACAGCCCATCTACTCTTAAATTTGAAGTTTATCCTGTATCT
TTAACTAAAACTGAGTTTGAGGATATTATCAAGCAGCTGGTTAAGAGATGGGCAGAACTT
CCAAAAGACACATTTTGGTCATATTTTTCACAAGTACAAGAAATCATGTGGACATTTAAT
GACATACTTAGAAAGTTCTGTAAGGATATAGTTTCAAATAAGAAACTTATGAAGAAACTA
CAGGAGTCAAGATTTGATGTTGTTCTTGCAGATGCTGTTTTCCCCTTTGGTGAGCTGCTG
GCCGAGTTACTTAAAATACCCTTTGTCTACAGGCCTCGCTTCTCTCCTGGCTACGCAATT
GAAAAGCATAGTGGAGGACTTCTGTTCCCTCCTTCCTATGTGCCTGTTGTTATGTCAGAA
CTAAGTGACCAAATGACTTTCATAGAGAGGGTAAAAAATATGATCTATGTGCTTTATTTT
GAATTTTGGTTCCAAATATTTGACATGAAGAAGTGGGATCAGTTCTACAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGCAAAAGCTGACATATGGCTTATTCGAAAC
TACTGGGATTTTCAATTTCCTCACCCACTCTTACCAAATGTTGAGTTCGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCGAAGGAAATGGAAGAGTTTGTCCAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCGATGGTCAGTAACACGTCAGAAGAAAGG
GCCAATGTAATTGCATCAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACTTTAGGACTCAATACTCGGCTGTACAAGTGGATACCCCAGAAT
GATCTTCTTGGTCACCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATAAGGCAATCTCTCCTAGAATCCCTATGGTGGGCGTTCCATTGTTTGCAGATCAACCT
GATAACATTGCACACATGAAGGCCAAGGGAGCAGCTGTTAGTTTGGACTTCCACACAATG
TCGAGTACAGACTTACTCAATGCACTGAAGACAGTAATTAATGATCCTTTATATAAAGAG
AATGCTATGAAATTATCAAGAATTCATCATGATCAACCAGTGAAGCCCCTTGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGACTGGGTTCCTGCTGGCCTGT
GTGGCAACTGTGATATTCATCATCACAAAATGTCTGTTTTGTGTCTGGAAGTTTGTTAGA
ACAGGAAAGAAGGGGAAAAGAGATTAA

# Metabolic_Enzyme_15_GenBank_ID_Gene:
Y00317

# Metabolic_Enzyme_15_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_15_Locus:
4q13

# Metabolic_Enzyme_15_SNPs:
rs13119049; rs41297431; rs13142440; rs1131878; rs1966151; rs1051752; rs7662902; rs1389930; rs1826690; rs7441743; rs1039007; rs2220857; rs2013562; rs1845557; rs6833511; rs13116232; rs12645716; rs9997034; rs1994936; rs1039008; rs4554145; rs28542932; rs10030234; rs10518061; rs17614939; rs13104260; rs10010875; rs3822179; rs33914959; rs1845556; rs6848208; rs17671289; rs1977017; rs28361541; rs41297733; rs41297437; rs1997581; rs41297373; rs41299996; rs41297395; rs41297371; rs41300016; rs41297381; rs41297421; rs1908406; rs41297427; rs41297377; rs41297425; rs41297367; rs4557343; rs1845558; rs3075630; rs41297405; rs41297739; rs41297383; rs41297721; rs13151870; rs41297441; rs13145834; rs13104687; rs11249442; rs41297407; rs41297429; rs41297727; rs1121124; rs2013573; rs41299994; rs13139888; rs41297439; rs41297409; rs1494802; rs13111134; rs6600771; rs6820660; rs6821129; rs941389; rs2736446; rs1080755; rs2736442; rs28858389; rs2736441; rs41298271; rs41298263; rs41299972; rs41298261; rs41298251; rs13129471; rs41299970; rs6821910; rs41298253; rs41298259; rs41298265; rs41298245; rs41299978; rs41299976; rs41299974; rs41300004; rs17852375; rs1845555; rs41298247; rs28679647; rs324405; rs41300006; rs36048401; rs1432328; rs41297387; rs41299984; rs41299998; rs41299992; rs41297735; rs41297423; rs35143721; rs1370886; rs41299980; rs41297389; rs41297729; rs7441132; rs41297435; rs34002802; rs41297731; rs41300018; rs35138624; rs41297391; rs41297369; rs41297737; rs41297413; rs13141359; rs41292303; rs41300008; rs2736447; rs41300014; rs41297401; rs34874998; rs1370887; rs41297399; rs41297379; rs172861; rs41297375; rs10613760; rs41297433; rs41297723; rs41297403; rs41297741; rs1821190; rs34030380; rs324406; rs41299986; rs41297393; rs41297385; rs41297419; rs41297365; rs35471760; rs34861432; rs4515233; rs324408; rs41297411; rs2018304; rs41300012; rs13114834; rs41297415; rs28629208; rs41300002; rs41300000; rs41300010; rs41297743; rs41297397; rs41299990; rs28419590; rs983988; rs34164957; rs1370885; rs324407; rs34466016; rs41297725; rs41297417; rs34114694; rs41299988; rs41299982; rs41299966; rs34846583; rs35045255; rs35834953; rs34169605; rs1318156; rs2642856; rs35159034; rs41298257; rs41298249; rs2736445; rs3075626; rs41299968; rs28847667; rs34146174; rs36057237; rs28812576; rs941390; rs41298255; rs28894673; rs41298269; rs1080756; rs41298267; rs10000231; rs10015297; rs11725944; rs11725945; rs13141436; rs13143630; rs1569343; rs1569344; rs1594588; rs1603119; rs1948499; rs2010468; rs2642849; rs2642872; rs2736462; rs2736476; rs2736517; rs2736520; rs35347166; rs4694749; rs7657880; rs903445; rs903446; rs9996511

# Metabolic_Enzyme_15_General_References:
3109396; 8333863; 10376768

# Metabolic_Enzyme_15_References:
Not Available

# Metabolic_Enzyme_16_ID:
5730

# Metabolic_Enzyme_16_Name:
UDP-glucuronosyltransferase 1-10 precursor

# Metabolic_Enzyme_16_Synonyms:
UDPGT; UGT1*10; UGT1-10; UGT1.10; UGT-1J; UGT1J

# Metabolic_Enzyme_16_Gene_Name:
UGT1A10

# Metabolic_Enzyme_16_Protein_Sequence:
>UDPglucuronosyltransferase 110 precursor
MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP
EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF
FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG
AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT
AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH
PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL
ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW
YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

# Metabolic_Enzyme_16_Number_of_Residues:
530

# Metabolic_Enzyme_16_Molecular_Weight:
59810

# Metabolic_Enzyme_16_Theoretical_pI:
7.31

# Metabolic_Enzyme_16_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_16_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_16_Specific_Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

# Metabolic_Enzyme_16_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_16_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_16_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_16_Signals:
1-25

# Metabolic_Enzyme_16_Transmembrane_Regions:
488-504

# Metabolic_Enzyme_16_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_16_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_16_GenBank_ID_Protein:
2039362

# Metabolic_Enzyme_16_SwissProt_ID:
UD110_HUMAN (Q9HAW8)

# Metabolic_Enzyme_16_swissprot_Name:
Not Available

# Metabolic_Enzyme_16_Genecard_id:
UGT1A10

# Metabolic_Enzyme_16_Geneatlas_id:
UGT1A10

# Metabolic_Enzyme_16_hgnc_id:
HGNC:12531

# Metabolic_Enzyme_16_PDB_ID:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_16_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_16_Subcellular_Location:
Microsome

# Metabolic_Enzyme_16_Gene_Sequence:
>1593 bp
ATGGCTCCGCGCAGGGTGGACCAGCCCCGTTCCTTTATGTGTGTGTCTACTGCTGACCTG
TGGCTTTGCGAGGCAGGGAAGCTGCTGGTAGTGCCCATGGATGGGAGTCACTGGTTCGCC
ATGCAGTCGGTGGTGGAGAAACTTATCCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGAAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCG
TACACTCTGGAAGATCAGAACCGGGAATTCATGGTTTTCGCCCATGCTCAATGGAAAGCA
CAGGCACAAAGTATATTTTCTCTATTAATGAGTTCATCCAGTGGTTTTCTTGACTTATTT
TTTTCGCATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGT
TCTTTTGATGCAGTGTTTCTGGATCCTTTTGATACCTGTGGCTTAATTGTTGCTAAATAT
TTCTCCCTCCCCTCTGTGGTCTTCACCAGGGGAATATTTTGCCGCCATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAATGATCTCTTAGGGTTCTCAGATGCC
ATGACTTTCAAGGAGAGAGTATGGAACCACATCGTGCACTTGGAGGACCATTTATTTTGC
CAGTATCTTTTAAGAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGTCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGTCATCAGGGA
AAGCCATTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
GTTAAGAAAGCCCACAAATCCAAGACCCATTGA

# Metabolic_Enzyme_16_GenBank_ID_Gene:
U89508

# Metabolic_Enzyme_16_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_16_Locus:
2q37

# Metabolic_Enzyme_16_SNPs:
Not Available

# Metabolic_Enzyme_16_General_References:
9271343; 11434514

# Metabolic_Enzyme_16_References:
Not Available

# Metabolic_Enzyme_17_ID:
5721

# Metabolic_Enzyme_17_Name:
UDP-glucuronosyltransferase 2B7 precursor

# Metabolic_Enzyme_17_Synonyms:
UDPGT; 3,4- catechol estrogen specific; UDPGTh-2

# Metabolic_Enzyme_17_Gene_Name:
UGT2B7

# Metabolic_Enzyme_17_Protein_Sequence:
>UDPglucuronosyltransferase 2B7 precursor
MSVKWTSVILLIQLSFCFSSGNCGKVLVWAAEYSHWMNIKTILDELIQRGHEVTVLASSA
SILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMSIFG
DITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSELLAELFNIPFVYSLSFSPGYTF
EKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVL
GRPTTLSETMGKADVWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSG
ENGVVVFSLGSMVSNMTEERANVIASALAQIPQKVLWRFDGNKPDTLGLNTRLYKWIPQN
DLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTM
SSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAA
HDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAKKGKND

# Metabolic_Enzyme_17_Number_of_Residues:
529

# Metabolic_Enzyme_17_Molecular_Weight:
60695

# Metabolic_Enzyme_17_Theoretical_pI:
8.45

# Metabolic_Enzyme_17_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_17_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_17_Specific_Function:
Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites

# Metabolic_Enzyme_17_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_17_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_17_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_17_Signals:
1-23

# Metabolic_Enzyme_17_Transmembrane_Regions:
493-509

# Metabolic_Enzyme_17_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_17_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_17_GenBank_ID_Protein:
340080

# Metabolic_Enzyme_17_SwissProt_ID:
UDB7_HUMAN (P16662)

# Metabolic_Enzyme_17_swissprot_Name:
Not Available

# Metabolic_Enzyme_17_Genecard_id:
UGT2B7

# Metabolic_Enzyme_17_Geneatlas_id:
UGT2B7

# Metabolic_Enzyme_17_hgnc_id:
HGNC:12554

# Metabolic_Enzyme_17_PDB_ID:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_17_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_17_Subcellular_Location:
Microsome

# Metabolic_Enzyme_17_Gene_Sequence:
>1590 bp
ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT
GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG
ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT
TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT
CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT
GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA
CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG
GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT
GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA
TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT
GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA
GGAAGACCCACTACGTTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC
TCCTGGAATTTTCAGTTTCCTCATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG
GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT
GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG
TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA
GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC
CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT
GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGCAAAGAAGGGAAAAAATGATTAG

# Metabolic_Enzyme_17_GenBank_ID_Gene:
J05428

# Metabolic_Enzyme_17_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_17_Locus:
4q13

# Metabolic_Enzyme_17_SNPs:
rs7439366; rs12233719; rs35590824; rs7438284; rs4348159; rs4292394; rs28365062; rs5013211; rs7686056; rs6600884; rs7441750; rs7439152; rs12513195; rs4293848; rs3924192; rs7442453; rs7698846; rs7678656; rs12506962; rs7441774; rs6600888; rs6858558; rs6600885; rs6600891; rs7375178; rs7435335; rs6600890; rs6600887; rs7438244; rs4521414; rs6600889; rs12647682; rs7434332; rs12508257; rs4694628; rs6600886; rs4314347; rs12647681; rs7439326; rs7698645; rs12512526; rs10028494; rs9995928; rs3924194; rs6600892; rs4364327; rs3924193; rs12642938; rs4337789; rs7679184; rs12648462; rs10050146; rs4257713; rs4588522; rs4356975; rs7693957; rs7658752; rs4314345; rs7438942; rs4351080; rs4541594; rs10006452; rs6851533; rs6600880; rs7438135; rs11940316; rs6600879; rs7668282; rs7668258; rs4538548; rs6600883; rs6600893; rs7662029; rs4455491; rs11940220; rs4554144; rs5859163; rs34620993; rs34851008; rs34308305; rs34661811; rs35327868; rs35893826; rs10022440; rs13136922; rs34407256; rs35452834; rs34095769; rs5859161; rs34241812; rs34302283; rs34386959; rs35475910; rs34561399; rs28675300; rs34556519; rs28673873; rs35185848; rs28539948; rs34571475; rs34318523; rs35402056; rs5859162; rs34182209; rs4694177; rs28375964; rs35605246; rs11302069; rs10008743; rs5859160; rs4356974; rs34630750; rs7437605; rs6819882; rs34590280; rs11249527; rs11249528; rs12506592; rs13118991; rs13135225; rs28365063; rs4274916; rs4358465; rs4434330; rs4535394; rs4694169; rs6422323; rs6422324; rs6600876; rs6843382; rs7437174; rs7657423; rs7676472

# Metabolic_Enzyme_17_General_References:
2159463; 11186130

# Metabolic_Enzyme_17_References:
Not Available

# Metabolic_Enzyme_18_ID:
5687

# Metabolic_Enzyme_18_Name:
UDP-glucuronosyltransferase 2B28 precursor

# Metabolic_Enzyme_18_Synonyms:
UDPGT

# Metabolic_Enzyme_18_Gene_Name:
UGT2B28

# Metabolic_Enzyme_18_Protein_Sequence:
>UDPglucuronosyltransferase 2B28 precursor
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSA
SILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFH
DIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTI
ERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVL
GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQN
DLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTM
SSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAA
RDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD

# Metabolic_Enzyme_18_Number_of_Residues:
529

# Metabolic_Enzyme_18_Molecular_Weight:
60907

# Metabolic_Enzyme_18_Theoretical_pI:
8.80

# Metabolic_Enzyme_18_GO_Classification:
>>>
Function:  catalytic activity
Function:  transferase activity
Function:  transferase activity, transferring glycosyl groups
Function:  transferase activity, transferring hexosyl groups
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_18_General_Function:
Carbohydrate transport and metabolism 

# Metabolic_Enzyme_18_Specific_Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active

# Metabolic_Enzyme_18_Pathway:
map00040  Pentose and glucuronate interconversions;
 map00150  Androgen and estrogen metabolism;
 map00500  Starch and sucrose metabolism;
 map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_18_Reaction:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside

# Metabolic_Enzyme_18_Pfam_Domain_Function:
PF00201:UDPGT

# Metabolic_Enzyme_18_Signals:
1-24

# Metabolic_Enzyme_18_Transmembrane_Regions:
495-517

# Metabolic_Enzyme_18_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_18_EC_Link:
EC 2.4.1.17

# Metabolic_Enzyme_18_GenBank_ID_Protein:
13603476

# Metabolic_Enzyme_18_SwissProt_ID:
UDB28_HUMAN (Q9BY64)

# Metabolic_Enzyme_18_swissprot_Name:
Not Available

# Metabolic_Enzyme_18_Genecard_id:
UGT2B28

# Metabolic_Enzyme_18_Geneatlas_id:
UGT2B28

# Metabolic_Enzyme_18_hgnc_id:
HGNC:13479

# Metabolic_Enzyme_18_PDB_ID:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_18_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_18_Subcellular_Location:
Microsome

# Metabolic_Enzyme_18_Gene_Sequence:
>1590 bp
ATGGCTCTGAAGTGGACTTCAGTTCTTCTGCTGATACATCTCGGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGACCGGTGAATACAGCCATTGGATGAATATGAAG
ACAATCCTGAAAGAGCTTGTTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT
TCCATTCTTTTTGATCCCAATGACGCATTCACTCTTAAACTCGAAGTTTATCCTACATCT
TTAACTAAAACTGAATTTGAGAATATCATCATGCAACAGGTTAAGAGATGGTCAGACATT
CAAAAAGATAGCTTTTGGTTATATTTTTCACAAGAACAAGAAATCCTGTGGGAATTTCAT
GACATATTTAGAAACTTCTGTAAAGATGTAGTTTCAAATAAGAAAGTTATGAAAAAACTA
CAAGAGTCAAGATTTGACATCATTTTTGCAGATGCTTTTTTTCCTTGTGGTGAGCTGCTG
GCTGCGCTACTTAACATACCGTTTGTGTACAGTCTCTGCTTCACTCCTGGCTACACAATT
GAAAGGCACAGTGGAGGACTGATTTTCCCTCCTTCCTACATACCTGTTGTTATGTCAAAA
TTAAGTGATCAAATGACTTTCATGGAGAGGGTAAAAAACATGATCTATGTGCTTTATTTT
GACTTTTGGTTCCAAATGTGTGATATGAAGAAGTGGGATCAGTTTTACAGTGAAGTTTTA
GGAAGACCCACTACCTTATTTGAGACAATGGGGAAAGCTGACATATGGCTTATGCGAAAC
TCCTGGAGTTTTCAATTTCCTCATCCATTCTTACCAAACATTGATTTTGTTGGAGGACTC
CACTGCAAACCTGCCAAACCCCTACCTAAGGAAATGGAGGAATTTGTACAGAGCTCTGGT
GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAGTGATAAGTAACATGACAGCAGAAAGG
GCCAACGTAATTGCAACAGCCCTTGCCAAGATCCCACAAAAGGTTCTGTGGAGATTTGAT
GGGAATAAACCAGATGCCTTAGGTCTCAATACTCGGCTGTATAAGTGGATACCCCAGAAT
GACCTTCTAGGTCTTCCAAAAACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC
TATGAGGCAATCTACCATGGGATCCCTATGGTAGGCATTCCATTGTTTTGGGATCAACCT
GATAACATTGCTCACATGAAGGCCAAGGGAGCAGCTGTTAGACTGGACTTCCACACAATG
TCGAGTACAGACCTGCTGAATGCACTGAAGACAGTAATTAATGATCCTTCATATAAAGAG
AATGTTATGAAATTATCAATAATTCAACATGATCAACCAGTAAAGCCCCTGCATCGAGCA
GTCTTCTGGATTGAATTTGTGATGTGCCACAAAGGAGCCAAACACCTTCGAGTTGCAGCC
CGTGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTTCTGCTGGCCTGT
GTGGCAACTGTGATATTTGTCGTCACAAAGTTTTGTCTGTTTTGTTTCTGGAAGTTTGCT
AGAAAAGGGAAGAAGGGAAAAAGAGATTAG

# Metabolic_Enzyme_18_GenBank_ID_Gene:
AF177272

# Metabolic_Enzyme_18_Chromosome_Location:
Chromosome:4

# Metabolic_Enzyme_18_Locus:
4q13.2

# Metabolic_Enzyme_18_SNPs:
rs4235127; rs4260604; rs4386668; rs11726210; rs10002503; rs4235126; rs3901337; rs4260603; rs10008843; rs4694712; rs4301173; rs4694711; rs2132039; rs9997242; rs4260602; rs4235125; rs4694713; rs7686786; rs10000077; rs7437560; rs7681187; rs10023367; rs7657406; rs41292949; rs6843900; rs6828191; rs41292951; rs10013145; rs7689398; rs41292341; rs13139691; rs13138824; rs4569811; rs6827801; rs34313836; rs5004177; rs28376412; rs13108235; rs5004180; rs4295327; rs4568294; rs4450998; rs33966513; rs5004176; rs35191928; rs13107778; rs4345242; rs34549399; rs4495113; rs5004183; rs41292945; rs41292947; rs35437714; rs35925451; rs13146763; rs28447469; rs35059283; rs5004182; rs7435249; rs5004175; rs5859170; rs4515230; rs6840320; rs35572829; rs5004178; rs5004179; rs4597901; rs41292339; rs5004181; rs13116501; rs10011666; rs41292343; rs7657045; rs13124875; rs9991645; rs35680160; rs6600920

# Metabolic_Enzyme_18_General_References:
11300766

# Metabolic_Enzyme_18_References:
Not Available

# Metabolic_Enzyme_19_ID:
5974

# Metabolic_Enzyme_19_Name:
Flavin reductase

# Metabolic_Enzyme_19_Synonyms:
FR; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP

# Metabolic_Enzyme_19_Gene_Name:
BLVRB

# Metabolic_Enzyme_19_Protein_Sequence:
>Flavin reductase
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ

# Metabolic_Enzyme_19_Number_of_Residues:
206

# Metabolic_Enzyme_19_Molecular_Weight:
22120

# Metabolic_Enzyme_19_Theoretical_pI:
7.76

# Metabolic_Enzyme_19_GO_Classification:
>>>
Function:  binding
Function:  cofactor binding
Function:  coenzyme binding
Function:  NAD binding
Function:  catalytic activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  nucleobase, nucleoside, nucleotide and nucleic acid metabolism
Process:  nucleotide-sugar metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_19_General_Function:
Cell wall/membrane/envelope biogenesis 

# Metabolic_Enzyme_19_Specific_Function:
Catalyzes electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin. Possible role in protecting cells from oxidative damage or in regulating iron metabolism. In the liver, converts biliverdin to bilirubin

# Metabolic_Enzyme_19_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_19_Reaction:
reduced riboflavin + NADP+ = riboflavin + NADPH + H+

# Metabolic_Enzyme_19_Pfam_Domain_Function:
PF01370:Epimerase

# Metabolic_Enzyme_19_Signals:
None

# Metabolic_Enzyme_19_Transmembrane_Regions:
None

# Metabolic_Enzyme_19_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_19_EC_Link:
EC 1.5.1.30;EC 1.3.1.24

# Metabolic_Enzyme_19_GenBank_ID_Protein:
1384068

# Metabolic_Enzyme_19_SwissProt_ID:
BLVRB_HUMAN (P30043)

# Metabolic_Enzyme_19_swissprot_Name:
Not Available

# Metabolic_Enzyme_19_Genecard_id:
BLVRB

# Metabolic_Enzyme_19_Geneatlas_id:
BLVRB

# Metabolic_Enzyme_19_hgnc_id:
HGNC:1063

# Metabolic_Enzyme_19_PDB_ID:
1HE5

# Metabolic_Enzyme_19_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_19_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_19_Subcellular_Location:
Cytoplasm (Potential)

# Metabolic_Enzyme_19_Gene_Sequence:
>621 bp
ATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCCTG
GCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTG
CCATCAGAGGGGCCCCGGCCGGCCCACGTGGTAGTGGGAGATGTTCTGCAGGCAGCCGAT
GTGGACAAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGAC
CTCAGTCCCACGACAGTGATGTCCGAGGGCGCCCGGAACATTGTGGCAGCCATGAAGGCT
CATGGTGTGGACAAGGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAG
GTGCCCCCACGACTGCAGGCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCGG
GAATCAGGCCTGAAGTACGTGGCTGTGATGCCGCCACACATAGGAGACCAGCCACTAACT
GGGGCGTACACAGTGACCCTGGATGGACGAGGGCCCTCAAGGGTCATCTCCAAACATGAC
CTGGGCCATTTCATGCTGCGCTGCCTCACCACCGATGAGTACGACGGACACAGCACCTAC
CCCTCCCACCAGTACCAGTAG

# Metabolic_Enzyme_19_GenBank_ID_Gene:
D26308

# Metabolic_Enzyme_19_Chromosome_Location:
Chromosome:19

# Metabolic_Enzyme_19_Locus:
19q13.1-q13.2

# Metabolic_Enzyme_19_SNPs:
rs1675404; rs1061197; rs268693; rs268692; rs268694; rs12459890; rs2169275; rs10421779; rs7255928; rs2613843; rs376112; rs9749496; rs10439101; rs41357045; rs12460618; rs268697; rs12981511; rs10439102; rs4803339; rs268696; rs10425814; rs268695; rs12460634; rs11878466; rs185593; rs268688; rs3745207; rs1804002; rs11547746; rs10281; rs1061340; rs7257546; rs7507689; rs34252952; rs34984704; rs36096038; rs28529139; rs35610866; rs10418696; rs35562498; rs35624785; rs34827058; rs34288924; rs35566164; rs34524101; rs28621979; rs4803340; rs12982125; rs426970; rs752212; rs2126121; rs28427504; rs12975787; rs28608147; rs34210692; rs4802078; rs444241; rs10698880; rs1058041; rs11667745; rs174865; rs183852; rs2168652; rs2368579; rs268690; rs268691; rs2887292; rs34004825; rs35314597; rs35754989; rs3745205; rs3745208; rs3760638; rs4803338; rs7259644

# Metabolic_Enzyme_19_General_References:
8117274; 8799475; 8280170; 7929092; 1286669; 8313871; 8687377; 11224564

# Metabolic_Enzyme_19_References:
Not Available

# Metabolic_Enzyme_20_ID:
7200

# Metabolic_Enzyme_20_Name:
Prothrombin precursor

# Metabolic_Enzyme_20_Synonyms:
Coagulation factor II[Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

# Metabolic_Enzyme_20_Gene_Name:
F2

# Metabolic_Enzyme_20_Protein_Sequence:
>Prothrombin precursor
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE

# Metabolic_Enzyme_20_Number_of_Residues:
622

# Metabolic_Enzyme_20_Molecular_Weight:
70037

# Metabolic_Enzyme_20_Theoretical_pI:
5.70

# Metabolic_Enzyme_20_GO_Classification:
>>>
Function:  thrombin activity
Function:  binding
Function:  ion binding
Function:  cation binding
Function:  calcium ion binding
Function:  catalytic activity
Function:  hydrolase activity
Function:  peptidase activity
Function:  endopeptidase activity
Function:  serine-type endopeptidase activity
 ||
>>>
Process:  organismal physiological process
Process:  regulation of body fluids
Process:  hemostasis
Process:  blood coagulation
Process:  physiological process
Process:  metabolism
Process:  macromolecule metabolism
Process:  protein metabolism
Process:  cellular protein metabolism
Process:  proteolysis
 ||
>>>
Component:  extracellular region

# Metabolic_Enzyme_20_General_Function:
Not Available

# Metabolic_Enzyme_20_Specific_Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C

# Metabolic_Enzyme_20_Pathway:
Not Available

# Metabolic_Enzyme_20_Reaction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

# Metabolic_Enzyme_20_Pfam_Domain_Function:
PF00594:Gla;
PF00051:Kringle;
PF00089:Trypsin

# Metabolic_Enzyme_20_Signals:
1-24

# Metabolic_Enzyme_20_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_20_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_20_EC_Link:
EC 3.4.21.5

# Metabolic_Enzyme_20_GenBank_ID_Protein:
339641

# Metabolic_Enzyme_20_SwissProt_ID:
THRB_HUMAN (P00734)

# Metabolic_Enzyme_20_swissprot_Name:
Not Available

# Metabolic_Enzyme_20_Genecard_id:
F2

# Metabolic_Enzyme_20_Geneatlas_id:
F2

# Metabolic_Enzyme_20_hgnc_id:
HGNC:3535

# Metabolic_Enzyme_20_PDB_ID:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_20_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_20_Subcellular_Location:
Secreted protein; extracellular space

# Metabolic_Enzyme_20_Gene_Sequence:
>1869 bp
ATGGCGCACGTCCGAGGCTTGCAGCTGCCTGGCTGCCTGGCCCTGGCTGCCCTGTGTAGC
CTTGTGCACAGCCAGCATGTGTTCCTGGCTCCTCAGCAAGCACGGTCGCTGCTCCAGCGG
GTCCGGCGAGCCAACACCTTCTTGGAGGAGGTGCGCAAGGGCAACCTAGAGCGAGAGTGC
GTGGAGGAGACGTGCAGCTACGAGGAGGCCTTCGAGGCTCTGGAGTCCTCCACGGCTACG
GATGTGTTCTGGGCCAAGTACACAGCTTGTGAGACAGCGAGGACGCCTCGAGATAAGCTT
GCTGCATGTCTGGAAGGTAACTGTGCTGAGGGTCTGGGTACGAACTACCGAGGGCATGTG
AACATCACCCGGTCAGGCATTGAGTGCCAGCTATGGAGGAGTCGCTACCCACATAAGCCT
GAAATCAACTCCACTACCCATCCTGGGGCCGACCTACAGGAGAATTTCTGCCGCAACCCC
GACAGCAGCACCACGGGACCCTGGTGCTACACTACAGACCCCACCGTGAGGAGGCAGGAA
TGCAGCATCCCTGTCTGTGGCCAGGATCAAGTCACTGTAGCGATGACTCCACGCTCCGAA
GGCTCCAGTGTGAATCTGTCACCTCCATTGGAGCAGTGTGTCCCTGATCGGGGGCAGCAG
TACCAGGGGCGCCTGGCGGTGACCACACATGGGCTCCCCTGCCTGGCCTGGGCCAGCGCA
CAGGCCAAGGCCCTGAGCAAGCACCAGGACTTCAACTCAGCTGTGCAGCTGGTGGAGAAC
TTCTGCCGCAACCCAGACGGGGATGAGGAGGGCGTGTGGTGCTATGTGGCCGGGAAGCCT
GGCGACTTTGGGTACTGCGACCTCAACTATTGTGAGGAGGCCGTGGAGGAGGAGACAGGA
GATGGGCTGGATGAGGACTCAGACAGGGCCATCGAAGGGCGTACCGCCACCAGTGAGTAC
CAGACTTTCTTCAATCCGAGGACCTTTGGCTCGGGAGAGGCAGACTGTGGGCTGCGACCT
CTGTTCGAGAAGAAGTCGCTGGAGGACAAAACCGAAAGAGAGCTCCTGGAATCCTACATC
GACGGGCGCATTGTGGAGGGCTCGGATGCAGAGATCGGCATGTCACCTTGGCAGGTGATG
CTTTTCCGGAAGAGTCCCCAGGAGCTGCTGTGTGGGGCCAGCCTCATCAGTGACCGCTGG
GTCCTCACCGCCGCCCACTGCCTCCTGTACCCGCCCTGGGACAAGAACTTCACCGAGAAT
GACCTTCTGGTGCGCATTGGCAAGCACTCCCGCACAAGGTACGAGCGAAACATTGAAAAG
ATATCCATGTTGGAAAAGATCTACATCCACCCCAGGTACAACTGGCGGGAGAACCTGGAC
CGGGACATTGCCCTGATGAAGCTGAAGAAGCCTGTTGCCTTCAGTGACTACATTCACCCT
GTGTGTCTGCCCGACAGGGAGACGGCAGCCAGCTTGCTCCAGGCTGGATACAAGGGGCGG
GTGACAGGCTGGGGCAACCTGAAGGAGACGTGGACAGCCAACGTTGGTAAGGGGCAGCCC
AGTGTCCTGCAGGTGGTGAACCTGCCCATTGTGGAGCGGCCGGTCTGCAAGGACTCCACC
CGGATCCGCATCACTGACAACATGTTCTGTGCTGGTTACAAGCCTGATGAAGGGAAACGA
GGGGATGCCTGTGAAGGTGACAGTGGGGGACCCTTTGTCATGAAGAGCCCCTTTAACAAC
CGCTGGTATCAAATGGGCATCGTCTCATGGGGTGAAGGCTGTGACCGGGATGGGAAATAT
GGCTTCTACACACATGTGTTCCGCCTGAAGAAGTGGATACAGAAGGTCATTGATCAGTTT
GGAGAGTAG

# Metabolic_Enzyme_20_GenBank_ID_Gene:
M17262

# Metabolic_Enzyme_20_Chromosome_Location:
Chromosome:11

# Metabolic_Enzyme_20_Locus:
11p11-q12

# Metabolic_Enzyme_20_SNPs:
rs5896; rs5898; rs3136452; rs3136532; rs5899; rs3136457; rs3136449; rs3136516; rs2282686; rs2070851; rs3136460; rs3136447; rs3136478; rs3136441; rs3136435; rs2070852; rs2282687; rs3136520; rs3136512; rs3136509; rs3136474; rs3136434; rs3136471; rs3136485; rs3136439; rs3136497; rs3136433; rs3136505; rs3136455; rs3136484; rs3136446; rs3136472; rs3136431; rs2070850; rs10838616; rs3136456; rs3136479; rs3136443; rs3136476; rs3136500; rs12574714; rs3136482; rs3136495; rs3136503; rs3136483; rs3136521; rs3136487; rs3136458; rs3136491; rs1799867; rs3136504; rs3136513; rs3136436; rs3136469; rs3136448; rs3136496; rs3136468; rs3136489; rs3136490; rs3136459; rs3136438; rs3136467; rs3136507; rs3136499; rs3136463; rs3136515; rs3136506; rs3136480; rs3136481; rs3136440; rs3136524; rs3136519; rs3136430; rs3136518; rs17854684; rs5897; rs1130873; rs5900; rs1799963; rs3136508; rs35768741; rs3136530; rs3136501; rs3136445; rs3136461; rs3136531; rs3136492; rs3891193; rs3136525; rs3136466; rs3136527; rs34428021; rs3136437; rs12787268; rs3136454; rs3136528; rs35690173; rs3136477; rs3136488; rs34747958; rs3136442; rs34204052; rs11038981; rs3926328; rs3136465; rs34647507; rs3136493; rs3136529; rs11038980; rs3136522; rs7123803; rs17847082; rs3136464; rs3136514; rs3926329; rs3136502; rs34284995; rs3136511; rs3136486; rs3136494; rs3136444; rs3136523; rs36050035; rs35150107; rs1129439; rs34296052; rs3136498; rs11438724; rs3136526; rs3136510; rs35817575; rs4752930; rs3136517; rs9794941; rs41275180; rs10838614; rs11038975; rs11038977; rs11038983; rs11038984; rs1130904; rs11604876; rs4076557; rs7938264

# Metabolic_Enzyme_20_General_References:
2825773; 6305407; 266717; 873923; 3759958; 2583108; 2374926; 8071320; 9214615; 10051558; 3771562; 7792730; 1421398; 7865694; 3242619; 2719946; 1354985; 3567158; 3801671; 1349838; 6405779; 10391209

# Metabolic_Enzyme_20_References:
16837801; 17006987; 17022748; 17058104

# Metabolic_Enzyme_21_ID:
5331

# Metabolic_Enzyme_21_Name:
Alkaline phosphatase, placental-like precursor

# Metabolic_Enzyme_21_Synonyms:
Alkaline phosphatase Nagao isozyme; Germ-cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

# Metabolic_Enzyme_21_Gene_Name:
ALPPL2

# Metabolic_Enzyme_21_Protein_Sequence:
>Alkaline phosphatase, placentallike precursor
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

# Metabolic_Enzyme_21_Number_of_Residues:
532

# Metabolic_Enzyme_21_Molecular_Weight:
57378

# Metabolic_Enzyme_21_Theoretical_pI:
6.31

# Metabolic_Enzyme_21_GO_Classification:
>>>
Function:  Not Available
 ||
>>>
Process:  physiological process
Process:  metabolism
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_21_General_Function:
Inorganic ion transport and metabolism 

# Metabolic_Enzyme_21_Specific_Function:
A phosphate monoester + H(2)O = an alcohol + phosphate

# Metabolic_Enzyme_21_Pathway:
map00361  gamma-Hexachlorocyclohexane degradation;
 map00790  Folate biosynthesis

# Metabolic_Enzyme_21_Reaction:
A phosphate monoester + H2O = an alcohol + phosphate

# Metabolic_Enzyme_21_Pfam_Domain_Function:
PF00245:Alk_phosphatase

# Metabolic_Enzyme_21_Signals:
1-19

# Metabolic_Enzyme_21_Transmembrane_Regions:
Not Available

# Metabolic_Enzyme_21_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_21_EC_Link:
EC 3.1.3.1

# Metabolic_Enzyme_21_GenBank_ID_Protein:
178428

# Metabolic_Enzyme_21_SwissProt_ID:
PPBN_HUMAN (P10696)

# Metabolic_Enzyme_21_swissprot_Name:
Not Available

# Metabolic_Enzyme_21_Genecard_id:
ALPPL2

# Metabolic_Enzyme_21_Geneatlas_id:
ALPPL2

# Metabolic_Enzyme_21_hgnc_id:
HGNC:441

# Metabolic_Enzyme_21_PDB_ID:
1EW2

# Metabolic_Enzyme_21_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_21_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_21_Subcellular_Location:
Cell membrane; lipid-anchor; GPI-anchor

# Metabolic_Enzyme_21_Gene_Sequence:
>1599 bp
ATGCAGGGGCCCTGGGTGCTGCTCCTGCTGGGCCTGAGGCTACAGCTCTCCCTGGGCATC
ATCCCAGTTGAGGAGGAGAACCCGGACTTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGT
GCCGCCAAGAAGCTGCAGCCTGCACAGACAGCCGCCAAGAACCTCATCATGTTCCTGGGT
GACGGGATGGGGGTGTCTACGGTGACAGCTGCCAGGATCCTAAAAGGGCAGAAGAAGGAC
AAACTGGGGCCTGAGACCTTCCTGGCCATGGACCGCTTCCCGTACGTGGCTCTGTCCAAG
ACATACAGTGTAGACAAGCATGTGCCAGACAGTGGAGCCACAGCCACGGCCTACCTGTGC
GGGGTCAAGGGCAACTTCCAGACCATTGGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGC
AACACGACACGCGGCAACGAGGTCATCTCCGTGGTGAATCGGGCCAAGAAAGCAGGAAAG
TCAGTGGGAGTGGTAACCACCACACGGGTGCAGCATGCCTCGCCAGCCGGCACCTACGCC
CACACGGTGAACCGCAACTGGTACTCGGATGCCGACGTGCCTGCCTCGGCCCGCCAGGAG
GGGTGCCAGGACATCGCCACGCAGCTCATCTCCAACATGGACATTGATGTGATCCTAGGT
GGAGGCCGAAAGTACATGTTTCCCATGGGGACCCCAGACCCTGAGTACCCAGATGACTAC
AGCCAAGGTGGGACCAGGCTGGACGGGAAGAATCTGGTGCAGGAATGGCTGGCGAAGCAC
CAGGGTGCCCGGTACGTGTGGAACCGCACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCT
GTGACCCATCTCATGGGTCTCTTTGAGCCTGGAGACATGAAATACGAGATCCACCGAGAC
TCCACACTGGACCCCTCCCTGATGGAGATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGG
AACCCCCGCGGCTTCTTCCTCTTCGTGGAGGGTGGTCGCATCGACCATGGTCATCATGAA
AGCAGGGCTTACCGGGCACTGACTGAGACGATCATGTTCGACGACGCCATTGAGAGGGCG
GGCCAGCTCACCAGCGAGGAGGACACGCTGAGCCTCGTCACTGCCGACCACTCCCACGTC
TTCTCCTTCGGAGGCTACCCCCTGCGAGGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAG
GCCCGGGACAGGAAGGCCTACACGGTCCTCCTATACGGAAACGGTCCAGGCTATGTGCTC
AAGGACGGCGCCCGGCCGGATGTTACGGAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAG
CAGTCAGCAGTGCCCCTGGACGGAGAGACCCACGCAGGCGAGGACGTGGCGGTGTTCGCG
CGCGGCCCGCAGGCGCACCTGGTTCACGGCGTGCAGGAGCAGACCTTCATAGCGCACGTC
ATGGCCTTCGCCGCCTGCCTGGAGCCCTACACCGCCTGCGACCTGGCGCCCCCCGCCGGC
ACCACCGACGCCGCGCACCCGGGGCCGTCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCA
GGGACCTTGCTGCTGCTGGGGACGGCCACTGCTCCCTGA

# Metabolic_Enzyme_21_GenBank_ID_Gene:
J03252

# Metabolic_Enzyme_21_Chromosome_Location:
Chromosome:2

# Metabolic_Enzyme_21_Locus:
2q37

# Metabolic_Enzyme_21_SNPs:
rs1048983; rs1048999; rs17416141; rs2090543; rs1048997; rs1009934; rs2678519; rs2697781; rs3828248; rs3828254; rs2697767; rs3828249; rs2697768; rs1048995; rs16836187; rs3116148; rs1130334; rs41265119; rs41265117; rs3111340; rs41265115; rs1049002; rs1049001; rs3189080; rs3924351; rs1049003; rs1130348; rs1130351; rs3924352; rs3189077; rs6728119; rs2091555; rs2945420; rs2678518; rs41265113; rs3111339; rs3833560; rs2678517; rs2945421; rs41265111; rs2091556; rs3830644; rs3828251; rs3828253; rs2697769; rs11363206; rs3828250; rs3828252; rs11678251; rs1001868; rs10195918; rs13002718; rs13003189; rs13412526; rs1878691; rs2082841; rs2082842; rs2139026; rs2139027; rs2573208; rs2573209; rs2697766; rs2697790; rs2697791; rs2697792; rs2697793; rs2741321; rs2853380; rs732581; rs744873; rs744874; rs790050; rs790051

# Metabolic_Enzyme_21_General_References:
2834730; 2745460; 2297757; 2162249; 3387245

# Metabolic_Enzyme_21_References:
15700767; 15756803

# Metabolic_Enzyme_22_ID:
6131

# Metabolic_Enzyme_22_Name:
Alanine aminotransferase 1

# Metabolic_Enzyme_22_Synonyms:
ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1

# Metabolic_Enzyme_22_Gene_Name:
GPT

# Metabolic_Enzyme_22_Protein_Sequence:
>Alanine aminotransferase 1
MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPF
TEVIRANIGD
AQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHS
LGAYSVSSGIQLIREDVARYI
ERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHT
RTGVLIPIPQYPLYSATLAELGAVQVDYYLDE
ERAWALDVAELHRALGQARDHCRPRAL
CVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVY
AAGSQFHSFKKVLMEM
GPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCP
PVPGQ
ALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSF
PRVQL
PPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPL
EKLRLLLEKLSRFHAK
FTLEYS

# Metabolic_Enzyme_22_Number_of_Residues:
496

# Metabolic_Enzyme_22_Molecular_Weight:
54638

# Metabolic_Enzyme_22_Theoretical_pI:
7.20

# Metabolic_Enzyme_22_GO_Classification:
>>>
Function:  transferase activity
Function:  transferase activity, transferring nitrogenous groups
Function:  catalytic activity
Function:  lyase activity
Function:  carbon-sulfur lyase activity
Function:  1-aminocyclopropane-1-carboxylate synthase activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  biosynthesis
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_22_General_Function:
Amino acid transport and metabolism 

# Metabolic_Enzyme_22_Specific_Function:
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles

# Metabolic_Enzyme_22_Pathway:
map00251  Glutamate metabolism;
 map00252  Alanine and aspartate metabolism;
 map00710  Carbon fixation

# Metabolic_Enzyme_22_Reaction:
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

# Metabolic_Enzyme_22_Pfam_Domain_Function:
PF00155:Aminotran_1_2

# Metabolic_Enzyme_22_Signals:
None

# Metabolic_Enzyme_22_Transmembrane_Regions:
None

# Metabolic_Enzyme_22_Metabolic_Importance:
Not Available

# Metabolic_Enzyme_22_EC_Link:
EC 2.6.1.2

# Metabolic_Enzyme_22_GenBank_ID_Protein:
1763096

# Metabolic_Enzyme_22_SwissProt_ID:
ALAT1_HUMAN (P24298)

# Metabolic_Enzyme_22_swissprot_Name:
Not Available

# Metabolic_Enzyme_22_Genecard_id:
GPT

# Metabolic_Enzyme_22_Geneatlas_id:
GPT

# Metabolic_Enzyme_22_hgnc_id:
HGNC:4552

# Metabolic_Enzyme_22_PDB_ID:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Image:
Not Available

# Metabolic_Enzyme_22_ThreeD_Structure_Text:
Not Available

# Metabolic_Enzyme_22_Subcellular_Location:
Cytoplasm

# Metabolic_Enzyme_22_Gene_Sequence:
>1491 bp

ATGGCCTCGAGCACAGGTGACCGGAGCCAGGCGGTGAGGCATGGACTGAGGGCGAAGGT
GCTGACGCTGG
ACGGCATGAACCCGCGTGTGCGGAGAGTGGAGTACGCAGTGCGTGGCC
CCATAGTGCAGCGAGCCTTGGA
GCTGGAGCAGGAGCTGCGCCAGGGTGTGAAGAAGCCT
TTCACCGAGGTCATCCGTGCCAACATCGGGGAC
GCACAGGCTATGGGGCAGAGGCCCAT
CACCTTCCTGCGCCAGGTCTTGGCCCTCTGTGTTAACCCTGATC
TTCTGAGCAGCCCCA
ACTTCCCTGACGATGCCAAGAAAAGGGCGGAGCGCATCTTGCAGGCGTGTGGGGG
CCAC
AGTCTGGGGGCCTACAGCGTCAGCTCCGGCATCCAGCTGATCCGGGAGGACGTGGCGCGG
TACATT
GAGAGGCGTGACGGAGGCATCCCTGCGGACCCCAACAACGTCTTCCTGTCCAC
AGGGGCCAGCGATGCCA
TCGTGACGGTGCTGAAGCTGCTGGTGGCCGGCGAGGGCCACA
CACGCACGGGTGTGCTCATCCCCATCCC
CCAGTACCCACTCTACTCGGCCACGCTGGCA
GAGCTGGGCGCAGTGCAGGTGGATTACTACCTGGACGAG
GAGCGTGCCTGGGCGCTGGA
CGTGGCCGAGCTTCACCGTGCACTGGGCCAGGCGCGTGACCACTGCCGCC
CTCGTGCGC
TCTGTGTCATCAACCCTGGCAACCCCACCGGGCAGGTGCAGACCCGCGAGTGCATCGAGG
C
CGTGATCCGCTTCGCCTTCGAAGAGCGGCTCTTTCTGCTGGCGGACGAGGTGTACCAG
GACAACGTGTAC
GCCGCGGGTTCGCAGTTCCACTCATTCAAGAAGGTGCTCATGGAGAT
GGGGCCGCCCTACGCCGGGCAGC
AGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCT
ACATGGGCGAGTGCGGGTTCCGCGGCGGCTATGT
GGAGGTGGTGAACATGGACGCTGCA
GTGCAGCAGCAGATGCTGAAGCTGATGAGTGTGCGGCTGTGCCCG
CCGGTGCCAGGACA
GGCCCTGCTGGACCTGGTGGTCAGCCCGCCCGCGCCCACCGACCCCTCCTTTGCGC
AGT
TCCAGGCTGAGAAGCAGGCAGTGCTGGCAGAGCTGGCGGCCAAGGCCAAGCTCACCGAGC
AGGTCTT
CAATGAGGCTCCTGGCATCAGCTGCAACCCAGTGCAGGGCGCCATGTACTCC
TTCCCGCGCGTGCAGCTG
CCCCCGCGGGCGGTGGAGCGCGCTCAGGAGCTGGGCCTGGC
CCCCGATATGTTCTTCTGCCTGCGCCTCC
TGGAGGAGACCGGCATCTGCGTGGTGCCAG
GGAGCGGCTTTGGGCAGCGGGAAGGCACCTACCACTTCCG
GATGACCATTCTGCCCCCC
TTGGAGAAACTGCGGCTGCTGCTGGAGAAGCTGAGCAGGTTCCATGCCAAG
TTCACCCT
CGAGTACTCCTGA

# Metabolic_Enzyme_22_GenBank_ID_Gene:
U70732

# Metabolic_Enzyme_22_Chromosome_Location:
Chromosome:8

# Metabolic_Enzyme_22_Locus:
8q24.3

# Metabolic_Enzyme_22_SNPs:
Not Available

# Metabolic_Enzyme_22_General_References:
9119391; 1931970; 11863375

# Metabolic_Enzyme_22_References:
15621157; 16317669; 16824075

# Metabolic_Enzyme_23_ID:
5383

# Metabolic_Enzyme_23_Name:
Heme oxygenase 2

# Metabolic_Enzyme_23_Synonyms:
HO-2

# Metabolic_Enzyme_23_Gene_Name:
HMOX2

# Metabolic_Enzyme_23_Protein_Sequence:
>Heme oxygenase 2
MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKG
NIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGEN
WEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST
GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQA
GSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFIL
AAGVALAAGLLAWYYM

# Metabolic_Enzyme_23_Number_of_Residues:
316

# Metabolic_Enzyme_23_Molecular_Weight:
36033

# Metabolic_Enzyme_23_Theoretical_pI:
5.09

# Metabolic_Enzyme_23_GO_Classification:
>>>
Function:  catalytic activity
Function:  oxidoreductase activity
Function:  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Function:  heme oxygenase (decyclizing) activity
 ||
>>>
Process:  physiological process
Process:  metabolism
Process:  cellular metabolism
Process:  heterocycle metabolism
Process:  porphyrin metabolism
Process:  heme metabolism
Process:  heme oxidation
 ||
>>>
Component:  Not Available

# Metabolic_Enzyme_23_General_Function:
Not Available

# Metabolic_Enzyme_23_Specific_Function:
Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter

# Metabolic_Enzyme_23_Pathway:
map00860  Porphyrin and chlorophyll metabolism

# Metabolic_Enzyme_23_Reaction:
heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O

# Metabolic_Enzyme_23_Pfam_Domain_Function:
PF01126:Heme_oxygenas